text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
after eliminating the reductones , the toxic activity is attributed to the peroxides and more especially to hydrogen peroxide . | NA | {
"id": "C0031180",
"name": "peroxides",
"pos": [
75,
84
]
} | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
108,
125
]
} |
significant increase of anti-fibrinogen antibodies is discussed in relation with the presence of autoantibodies frequently discovered along trypanosomiasis . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
40,
50
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
97,
111
]
} |
the clone n32 derived from ems-treated f137 is deficient in n-acetyl hexosaminidase a and b but contains normal levels of n-acetyl hexosaminidase c and low levels of an enzyme resembling n-acetyl hexosaminidase s . | NA | {
"id": "C0162330",
"name": "hexosaminidase a",
"pos": [
69,
85
]
} | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
196,
210
]
} |
carbonic anhydrase i and ii , lactate dehydrogenase , malate dehydrogenase , nucleoside phosphorylase , triose phosphate isomerase , haemoglobin a and haemoglobin a2 . | NA | {
"id": "C0019016",
"name": "haemoglobin a",
"pos": [
133,
146
]
} | {
"id": "C0019019",
"name": "haemoglobin a2",
"pos": [
151,
165
]
} |
the data indicate that netilmicin is less nephrotoxic than gentamicin in rats , that the difference in nephrotoxicity can not be explained by a difference in drug concentration in the renal cortex , and that the ability of aminoglycosides to stimulate the organic acid transport system of proximal tubular cells does not correlate with their nephrotoxic potential . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
59,
69
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
223,
238
]
} |
in vitro studies were performed to evaluate the activity of cefaclor in comparison with cephalexin against 180 clinical isolates . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
60,
68
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
88,
98
]
} |
broth dilution susceptibility tests showed cefaclor to be 4- to 16-fold more active than cephalexin against streptococcus pneumoniae , haemophilus influenzae , and cephalothin-susceptible enterobacteriaceae . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
43,
51
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
89,
99
]
} |
cefaclor zones with 30-mug disks were generally larger than cephalexin zones , 4 mm larger than cephalothin zones against enterobacteriaceae , and 6 mm smaller than cephalothin zones against s. aureus . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
60,
70
]
} |
quantitative kill curves indicated that killing by both cefaclor and cephalexin was slow and often incomplete over a 24-h period . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
56,
64
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
69,
79
]
} |
cefaclor-induced filamentation of gram-negative bacilli was not as extensive as that produced by cephalexin , and some spherule formation did occur . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
97,
107
]
} |
however , cefaclor was significantly more unstable in solution than cephalexin , with a half-life of less than 6 h at 37 degrees c . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
10,
18
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
68,
78
]
} |
cefaclor , a new oral cephalosporin , was compared in vitro with cephalexin and cephradine against 233 organisms . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
65,
75
]
} |
cefaclor , a new oral cephalosporin , was compared in vitro with cephalexin and cephradine against 233 organisms . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
65,
75
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
80,
90
]
} |
in agar , cefaclor had greater antibacterial activity than either cephalexin or cephradine against isolates of escherichia coli , proteus mirabilis , staphylococcus aureus , klebsiella pneumoniae , and salmonella typhi . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
10,
18
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
66,
76
]
} |
in agar , cefaclor had greater antibacterial activity than either cephalexin or cephradine against isolates of escherichia coli , proteus mirabilis , staphylococcus aureus , klebsiella pneumoniae , and salmonella typhi . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
66,
76
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
80,
90
]
} |
cefaclor was the most active , cephalexin had intermediate activity , and cephradine was the least active . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
31,
41
]
} |
cefaclor was the most active , cephalexin had intermediate activity , and cephradine was the least active . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
31,
41
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
74,
84
]
} |
from the data obtained in this in vitro study , it can be concluded that cefaclor , which has a substituted chloro group attached to the molecule , had increased antibacterial activity over cephalexin and cephradine . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
73,
81
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
190,
200
]
} |
from the data obtained in this in vitro study , it can be concluded that cefaclor , which has a substituted chloro group attached to the molecule , had increased antibacterial activity over cephalexin and cephradine . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
190,
200
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
205,
215
]
} |
standard curves for amikacin , kanamycin , gentamicin , and tobramycin in the acetylating assay were all abnormal with standards prepared in the in pool . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
20,
28
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
31,
40
]
} |
they were compared in vitro with cephalexin , cephaloglycin , and cepharadine against a variety of aerobic pathogenic bacteria by an agar dilution procedure . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
33,
43
]
} | {
"id": "C0007721",
"name": "cephaloglycin",
"pos": [
46,
59
]
} |
cefaclor and cefatrizine were found to be similar or superior to cephalexin , cephaloglycin , and cephradine in terms of activity against gram-positive cocci other than enterococci . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
65,
75
]
} |
cefaclor and cefatrizine were found to be similar or superior to cephalexin , cephaloglycin , and cephradine in terms of activity against gram-positive cocci other than enterococci . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
65,
75
]
} | {
"id": "C0007721",
"name": "cephaloglycin",
"pos": [
78,
91
]
} |
cefaclor and cefatrizine were found to be similar or superior to cephalexin , cephaloglycin , and cephradine in terms of activity against gram-positive cocci other than enterococci . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
65,
75
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
98,
108
]
} |
filters of different pore sizes retained endotoxin lipopolysaccharide presumed to be in the vesicle form , the micelle form , or the detergent-solubilized form in aqueous solutions . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
41,
50
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
51,
69
]
} |
moreover , since lps from rough forms was active , the o-specific polysaccharide of the lps was not required for activity . | NA | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
55,
80
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
88,
91
]
} |
the cases are reported of three patients with rare tumors of the mammary gland : one osteogenic sarcoma , one benign mixed tumor and one reticulum-cell sarcoma of the breast . | NA | {
"id": "C0001430",
"name": "tumors of the",
"pos": [
51,
64
]
} | {
"id": "C0026277",
"name": "benign mixed tumor",
"pos": [
110,
128
]
} |
a 9-year-old boy with mental deterioration and epilepsy suffered an acute attack of hereditary coproporphyria associated with worsening of seizure control . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
47,
55
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
139,
146
]
} |
[ potentiation by metanephrine and normetanephrine of the arrythmic effect of adrenaline and noradrenaline in the cat ( author 's transl ) ] . | NA | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
18,
30
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} |
[ potentiation by metanephrine and normetanephrine of the arrythmic effect of adrenaline and noradrenaline in the cat ( author 's transl ) ] . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
35,
50
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
93,
106
]
} |
[ potentiation by metanephrine and normetanephrine of the arrythmic effect of adrenaline and noradrenaline in the cat ( author 's transl ) ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
78,
88
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
93,
106
]
} |
although kasai 's hepatic portoenterostomy operation for biliary atresia is the most dramatic example , radical departures from conventional surgical treatment also have been advocated for choledochal cyst , caroli 's disease , congenital perforation of the bile ducts and biliary hypoplasia . | NA | {
"id": "C0008340",
"name": "choledochal cyst",
"pos": [
189,
205
]
} | {
"id": "C0162510",
"name": "caroli 's disease",
"pos": [
208,
225
]
} |
from 1950 to 1973 , 254 patients with metastatic cancers from occult primary tumors , comprising 0.5 % of all the referred cancer patients were seen . | NA | {
"id": "C0027627",
"name": "metastatic cancers",
"pos": [
38,
56
]
} | {
"id": "C0027667",
"name": "occult primary",
"pos": [
62,
76
]
} |
ethanol suppresses the escape response in doses of 2.0 and 3.0 g/kg which produce mean blood ethanol concentrations of 1.88 and 3.28 mg/ml , respectively . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
0,
7
]
} | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
87,
115
]
} |
since narcotic antagonists such as naloxone may be employed in studying the phenomenon of physical dependence on ethanol based on the hypothesis of a relationship between endogenous opiates and ethanol dependence , it is essential to verify that blood ethanol concentrations are low enough so that ethanol will not interfere with the effects of naloxone in ethanol dependent animals . | NA | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
246,
274
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
357,
364
]
} |
cyclic amp and dibutyryl cyclic amp as well as several 8-substituted analogs of cyclic amp inhibited in vitro human blood neutrophil chemotaxis . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
15,
35
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
80,
90
]
} |
tissue uptake of total-14c and disopyramide ( dp ) was examined in rats following 5 to 100 mg/kg doses of [ 14c ] -disopyramide phosphate [ 14c-dpp ] . | NA | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
31,
43
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
115,
137
]
} |
n-allylnorazidomorphine ( nam ) , n-allyl-14-hydroxynorazidomorphine ( noam ) , n-cyclopropylmethylnorazidomorphine ( cam ) and n-cyclopropylmethyl-14-hydroxynorazidomorphine ( coam ) were synthetized and their pharmacological effect in comparison to naloxone and naltrexone were analyzed . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
251,
259
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
264,
274
]
} |
while naloxone and naltrexone are pure antagonists at all points , the n-substituted norazidomorphines were found to be more potent antagonists than naloxone in some of the tests and extremely potent pure agonists in others . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
6,
14
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
19,
29
]
} |
several d-lysergic acid diethylamide ( lsd ) derivatives including metabolites of lsd in animals liver and streptomyces such as d-lysergic acid ethyl , 2-hydroxyethylamide ( leo ) , d-lysergic acid ethylamide ( lae ) , d-norlysergic acid diethylamide ( norlsd ) and synthetic n6-allyl-d-norlysergic acid diethylamide ( allyl-nor lsd ) were studied with rabbits and rats . | NA | {
"id": "C0369632",
"name": "lysergic acid",
"pos": [
10,
23
]
} | {
"id": "C0024334",
"name": "lsd",
"pos": [
329,
332
]
} |
in rabbits , the order of the hyperthermic activities was allyl-norlsd greater than lsd greater than leo , lae , nor-lsd , and this order was parallel to that of 5-hydroxytryptamine-like activities of these compounds which was previously studied . | NA | {
"id": "C0369632",
"name": "lae",
"pos": [
107,
110
]
} | {
"id": "C0024334",
"name": "lsd",
"pos": [
117,
120
]
} |
in the dogs pretreated with t3 much higher increases in the plasma ffa concentration were found both during noradrenaline and adrenaline infusions in comparison with control experiments . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
108,
121
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
126,
136
]
} |
the lower sensitivity to catecholamine-induced arrhythmias with hypercapnic acidosis does not appear to be related to the re-uptake of the neurotransmitter by the nerve ending since it is also present with isoproterenol . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
25,
38
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
206,
219
]
} |
in eight male patients with alcoholic delirium concentrations of 3-methoxy-4-hydroxyphenylglycol ( mhpg ) and homovannilic acid ( hva ) in csf , activity of dopamine-beta-hydroxylase ( dbh ) and urinary excretion of noradrenaline ( na ) , adrenaline ( a ) , and dopamine ( da ) were measured during the delirium and a drug-free control period . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
216,
229
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
239,
249
]
} |
zn was added to the incubation solution as zncl2 or as zncl2 mixed with histidine in a molar ratio of 200 : 1 and mixed with edta in a molar ratio of 1 : 1 or 10 : 1 . | NA | {
"id": "C0043481",
"name": "zn",
"pos": [
0,
2
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
55,
60
]
} |
the dnp in a concentrationof 0.05 mm proved sufficient to greatly inhibit the uptake and transfer of zn from the solution containing zncl2 mixed with an excess of histidine . | NA | {
"id": "C0043481",
"name": "zn",
"pos": [
101,
103
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
133,
138
]
} |
ouabain at the contration of 5 mm and 10 mm greatly reduced zn uptake by the intestinal wall and the celluar zn transfer from the solution containing zncl2 and histidine . | NA | {
"id": "C0043481",
"name": "zn",
"pos": [
60,
62
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
150,
155
]
} |
there was only a small effect of ouabain on zn absorption whether zncl2 is added alone or with edta . | NA | {
"id": "C0043481",
"name": "zn",
"pos": [
44,
46
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
66,
71
]
} |
in contrast to this , the addition of edta to zncl2 reduces the intestinal zn uptake and increases the transfer of zn compared to zncl2 alone . | NA | {
"id": "C0043481",
"name": "zn",
"pos": [
46,
48
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
130,
135
]
} |
acute alcoholic hepatitis is a connecting link between steatosis and cirrhosis of the liver in which the accompanying autoimmune mechanism and microcirculation disorder followed by activation of lipofibroblasts are conducive to the progression of the pathologic process . | NA | {
"id": "C0012634",
"name": "disorder",
"pos": [
160,
168
]
} | {
"id": "C0030660",
"name": "pathologic process",
"pos": [
251,
269
]
} |
the extent of habituation to accelerations which initially produced motion sickness was evaluated , along with the possible value of habituation training to minimize the space motion sickness problem . | NA | {
"id": "C0026603",
"name": "motion sickness",
"pos": [
68,
83
]
} | {
"id": "C0242700",
"name": "space motion sickness",
"pos": [
170,
191
]
} |
ranking of the various buffer anions tested , according to increasing heat stabilization , was water less than acetate less than or equal to phosphate less than citrate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
30,
36
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
141,
150
]
} |
catalytic studies on the purified intact salmon isozyme system and on the isozymically pure aalpha4 and abeta4 homotetramers from brown trout ( salmo trutta ) revealed no significant differences in catalytic properties among these enzymes , suggesting equivalent catalytic function of aalpha and abeta . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
48,
55
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
231,
238
]
} |
a maximum of 22 bands comprising four esterase subgroups -- acetylesterase , carboxylesterase , cholinesterase , and acetylcholinesterase -- were detected following electrophoresis of lesser snow goose sera on polyacrylamide gels . | NA | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
96,
110
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
117,
137
]
} |
the specificity of complex-formation between dinitrophenyl and tryptophan is confirmed by the lack of ring-current shifts of the dinitrophenyl resonances when tryptophan is replaced by any other aromatic amino acid . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
63,
73
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
195,
214
]
} |
it is not yet clear whether the binding protein is a true cytosol protein or an easily solubilized membrane protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
40,
47
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
99,
115
]
} |
sequence analyses of precursors labelled with [ ( 3 ) h ] glutamine and [ ( 3 ) h ] glutamic acid showed incorporation only of glutamine in a position that matches with the position of pyrrolid-2-one-5-carboxylic acid in the mature forms of all three precursors , and incorporation of glutamic acid in other positions . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
58,
67
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
285,
298
]
} |
a nuclear protein kinase that shows a high degree of substrate specificity for the phosphorylation of the acidic proteins casein , phosvitin and non-histone chromatin proteins , rather than the basic proteins histones and protamine , was partially purified from lactatingrat mammary gland . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
2,
17
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
200,
208
]
} |
a nuclear protein kinase that shows a high degree of substrate specificity for the phosphorylation of the acidic proteins casein , phosvitin and non-histone chromatin proteins , rather than the basic proteins histones and protamine , was partially purified from lactatingrat mammary gland . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
2,
17
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
209,
217
]
} |
a nuclear protein kinase that shows a high degree of substrate specificity for the phosphorylation of the acidic proteins casein , phosvitin and non-histone chromatin proteins , rather than the basic proteins histones and protamine , was partially purified from lactatingrat mammary gland . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
2,
17
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
222,
231
]
} |
[ ile5 ] angiotensin ii ( angiotensin ) derivatives bearing acetyl , propionyl , butyryl , pentanoyl or hexanoyl moieties at the n-terminal amino group were synthesized . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
9,
23
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
26,
37
]
} |
the interaction of triton x-100 with soluble proteins : possible implications for the transport of proteins across membranes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
45,
53
]
} | {
"id": "C0007292",
"name": "transport",
"pos": [
86,
95
]
} |
a very sharp difference in elimination between the two modes of treatment must be associated with a difference in metabolism . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
27,
38
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
114,
124
]
} |
in a modified ames test system the unsymmetrically substituted chlorinated ethylenes are found mutagenic ( tri-,1,1-dichloroethylene and vinyl chloride ) , whereas symmetrically substituted molecules are inactive . | NA | {
"id": "C0015096",
"name": "ethylenes",
"pos": [
75,
84
]
} | {
"id": "C0012074",
"name": "dichloroethylene",
"pos": [
116,
132
]
} |
3 ) values of serum immunoglobulins in 19 cases of glioblastoma multiforme were compared with those in 18 cases of astrocytoma to know the relationship between histological malignancy and levels of serum immunoglubulins . | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
51,
63
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
115,
126
]
} |
during tumour regression , cellular degradation is evident in fibroblast-like and irregularly shaped cells as well as round cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
62,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
however 17-oxosteroids such as androstenedione , 5alpha-androstanedione and androsterone were also formed from testosterone and were the major metabolites of scalp and forehead skin . | NA | {
"id": "C0000167",
"name": "17-oxosteroids",
"pos": [
8,
22
]
} | {
"id": "C0002860",
"name": "androstanedione",
"pos": [
56,
71
]
} |
however 17-oxosteroids such as androstenedione , 5alpha-androstanedione and androsterone were also formed from testosterone and were the major metabolites of scalp and forehead skin . | NA | {
"id": "C0000167",
"name": "17-oxosteroids",
"pos": [
8,
22
]
} | {
"id": "C0002865",
"name": "androsterone",
"pos": [
76,
88
]
} |
the conjugated equine oestrogen ( 1.25 mg daily ) and oestrogen valerate ( 2 mg daily ) treated groups did not show abnormal glucose tolerance . | NA | {
"id": "C0014938",
"name": "conjugated",
"pos": [
4,
14
]
} | {
"id": "C0014939",
"name": "oestrogen",
"pos": [
54,
63
]
} |
the major neutral gsls of tonsil lymphocytes are glucosyl ceramide ( cmh ) , lactosyl ceramide ( cdh ) , trihexosyl ceramide ( cth ) , and globoside . | NA | {
"id": "C0007745",
"name": "ceramide",
"pos": [
58,
66
]
} | {
"id": "C0017647",
"name": "globoside",
"pos": [
139,
148
]
} |
thymocytes and pbl contained mostly hematoside , whereas tonsil lymphocytes contained more complex gangliosides in addition to hematoside . | NA | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
99,
111
]
} | {
"id": "C0016897",
"name": "hematoside",
"pos": [
127,
137
]
} |
the in vitro product has the same mobility in polyacrylamide-sodium dodecyl sulfate gels as purified rat liver albumin and can be immune precipitated with rabbit anti-rat liver albumin serum . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
111,
118
]
} | {
"id": "C0036773",
"name": "albumin serum",
"pos": [
177,
190
]
} |
the binding of hemoglobin to the red cell membrane was characterized over a wide range of free hemoglobin concentrations by measurement of membrane bound and supernatant hemoglobin . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
47,
48
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
170,
180
]
} |
analogs of l-carnitine containing a quarternary ammonium group were found to inhibit uptake ( d-carnitine , ki = 400 micron ; gamma-butyrobetaine , ki = 60 micron , choline chloride , ki = 14 mm ) , while those not containing this functional group ( gamma-aminobutyrate , d , l-beta-hydroxybutyrate ) had no significant effect at concentrations 100 times the apparent km of l-carnitine . | NA | {
"id": "C2917324",
"name": "analogs",
"pos": [
0,
7
]
} | {
"id": "C0087163",
"name": "l-carnitine",
"pos": [
374,
385
]
} |
the fractionation resulted in a separation of vesicle populations bearing four different enzymes : alkaline nitrophenyl-phosphatase ( orthophosphoric-monoester phosphohydrolase ( alkalin optimum ) ec 3.1.3.1 ) , gamma-glutamyltransferase ( ec 2.3.2.2 ) , ( mg2+ + na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) and acyl-coa : lysophosphatidylcholine acyltransferase ( acyl-coa:1-acylglycero-3-phosphocholine-o-acyltransferase , ec 2.3.1.23 ) . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
11,
13
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
285,
305
]
} |
the fractionation resulted in a separation of vesicle populations bearing four different enzymes : alkaline nitrophenyl-phosphatase ( orthophosphoric-monoester phosphohydrolase ( alkalin optimum ) ec 3.1.3.1 ) , gamma-glutamyltransferase ( ec 2.3.2.2 ) , ( mg2+ + na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) and acyl-coa : lysophosphatidylcholine acyltransferase ( acyl-coa:1-acylglycero-3-phosphocholine-o-acyltransferase , ec 2.3.1.23 ) . | NA | {
"id": "C0024353",
"name": "lysophosphatidylcholine acyltransferase",
"pos": [
336,
375
]
} | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
420,
435
]
} |
this process had a higher affinity for cl ( kcl = 94 mm ) than for na ( kna = 155 mm ) , maximally transported twice as much cation as anion ( jna max = 1.6 ; jcl max = 0.75 mumol-cm-2-h-1 ) , and exhibited identical hill interaction indices for both ions nna = 3.4 ; | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
125,
131
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
251,
255
]
} |
this process had a higher affinity for cl ( kcl = 94 mm ) than for na ( kna = 155 mm ) , maximally transported twice as much cation as anion ( jna max = 1.6 ; jcl max = 0.75 mumol-cm-2-h-1 ) , and exhibited identical hill interaction indices for both ions nna = 3.4 ; | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
135,
140
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
251,
255
]
} |
the suggestion is made that this cooperative carrier mechanism may be regulatory , maintaining relatively constant luminal ion concentrations which , in turn may facilitate ion-dependent absorption of non-electrolytes . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
11,
14
]
} | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
205,
217
]
} |
histones and other basic nuclear proteins in genetically active and genetically inactive nuclei of the ciliate , oxytricha sp . | NA | {
"id": "C0019652",
"name": "histones",
"pos": [
0,
8
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
25,
41
]
} |
the stimulation of rna synthesis by the nuclear rna fraction is due to the conversion of inaccessible region of dna to rna polymerase into an accessible one and presumably not due to an increase in the number of binding sites for rna polymerase in the chromatin . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
19,
22
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
40,
51
]
} |
synthetic polynucleotide , poly ( da ) - oligo ( dt ) 10 was found to have a high efficiency under the same condition for activated dna . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
10,
24
]
} | {
"id": "C0028953",
"name": "oligo",
"pos": [
41,
46
]
} |
in addition to the previously identified major satellite dna , there are two minor dna components banding at 1.682 and 1.701 g - cm ( -3 ) in cscl . | NA | {
"id": "C0012934",
"name": "satellite",
"pos": [
47,
56
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
83,
86
]
} |
the nuclear protein kinases preferred casein and phosvitin to histone as substrates and were cyclic amp-independent . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
4,
19
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
62,
69
]
} |
nuclear protein kinase activities increased greater than two-fold , when expressed as units of activity per cell nucleus , during g1 phase traverse , concomitant with a 70 % increase in nuclear non-histone proteins ( those soluble in 0.6 m nacl ) . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
0,
7
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
198,
205
]
} |
protamine messenger rna from rainbow trout testis contains the nucleotide sequence a-a-u-a-a-a in an untranslated region . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
10,
23
]
} | {
"id": "C0600680",
"name": "untranslated region",
"pos": [
101,
120
]
} |
ataxia telangiectasia , bloom 's syndrome and normal fibroblasts were compared as to the capacity of their cellular extracts to enhance the priming activity of gamma-irradiated colicin e1 dna for purified dna polymerase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
53,
64
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
107,
115
]
} |
different from all lipoprotein structures known so far lipoprotein-x is a hollow particle ( = vesicle ) with a water-filled internal cavity surrounded by a continuous , single bilayer which is impermeable to cations and k3fe ( cn ) 6 . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
19,
30
]
} | {
"id": "C0023819",
"name": "lipoprotein-x",
"pos": [
55,
68
]
} |
they hydrolyse lactose , cellobiose and synthetic beta-d-galactosides , -glucosides and -fucosides at a ph optimum of 5,2 to 5,6 and are inactive on alpha-glycosides . | NA | {
"id": "C0016956",
"name": "galactosides",
"pos": [
57,
69
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
155,
165
]
} |
they hydrolyse lactose , cellobiose and synthetic beta-d-galactosides , -glucosides and -fucosides at a ph optimum of 5,2 to 5,6 and are inactive on alpha-glycosides . | NA | {
"id": "C0017765",
"name": "glucosides",
"pos": [
73,
83
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
155,
165
]
} |
under conditions of the ca+-atpase reaction in the presence of creatine phosphate the release of creatine into the reaction medium is observed , the rate of the latter process being dependent upon the mgatp concentration in accordance with the kinetic parameters of the ca2+-atpase reaction . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
28,
34
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
270,
273
]
} |
under conditions of the ca+-atpase reaction in the presence of creatine phosphate the release of creatine into the reaction medium is observed , the rate of the latter process being dependent upon the mgatp concentration in accordance with the kinetic parameters of the ca2+-atpase reaction . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
63,
81
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
97,
105
]
} |
specific developmental malformations have been demonstrated in the occipital bone of two chondrodysplastic disorders ( achondroplasia and thanatophoric dwarfism ) . | NA | {
"id": "C0001080",
"name": "achondroplasia",
"pos": [
119,
133
]
} | {
"id": "C0039743",
"name": "thanatophoric",
"pos": [
138,
151
]
} |
granulocytic ( colony-forming units in culture , or cfu-c ) and erythrocytic ( erythropoietin-responsive cells , or erc ) progenitor cells in canine cyclic hematopoiesis ( ch ) have been shown to fluctuate over the cycle and in the same phases as one another . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
105,
110
]
} | {
"id": "C0018956",
"name": "progenitor cells",
"pos": [
122,
138
]
} |
the adp- and collagen-induced aggregation of platelets in prp of healthy probands was tested in vitro in the presence of 4 heparin preparations ( novo , vitrum , liquemin , haemoderivate ) and of a heparinoid ( eleparon ) . | NA | {
"id": "C0019134",
"name": "heparin preparations",
"pos": [
123,
143
]
} | {
"id": "C0019142",
"name": "heparinoid",
"pos": [
198,
208
]
} |
2 ( - ) -noradrenaline ( na ) , ( - ) -adrenaline , or ( - ) -isoprenaline ( isop ) produced intermittent or sustained electrocortical desynchronization during the perfusion period . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
9,
22
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
39,
49
]
} |
4 the effects of na or isop were also blocked by phentolamine , whereas phenoxybenzamine either potentiated the responses to na and isop or mimicked the effects of these catecholamines . | NA | {
"id": "C0022245",
"name": "isop",
"pos": [
23,
27
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
170,
184
]
} |
the nucleus accumbens septi and tuberculum olfactorium ( nas-to ) , which from part of the mesolimbic dopaminergic system , and the striatum , which is part of the nigrostriatal dopamingeric system , contain high levels of both dopamine ( da ) and acetylcholine and resemble each other in some other biochemical properties . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
102,
114
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
228,
236
]
} |
the potencies of synthetic methionine- and leucine-enkephalin in eliciting analgesia were less than 1 % of those of partially purified enkephalin extracts when doses of equivalent ability to compete for opiate receptor binding were compared . | NA | {
"id": "C0014294",
"name": "leucine-enkephalin",
"pos": [
43,
61
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
135,
145
]
} |
immunoperoxidase techniques and light microscopy were used to investigate the origin of the fibers containing vasopressin , oxytocin and related neurophysins ( neurohypophyseal peptides ) , in the zona externa of the median emience of the rhesus monkey . | NA | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
124,
132
]
} | {
"id": "C0032017",
"name": "neurohypophyseal peptides",
"pos": [
160,
185
]
} |
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