text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
adenine nucleotides synthesized from [ 14c ] adenine were slowly catabolized to allantoin , with little incorporationof radioactivity into other purine compounds . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
0,
7
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
145,
151
]
} |
the diacylglycerol acyltransferase did not exhibit any selectivity against hexaenoic precursors under the assay conditions used ( 0.25 mm diacylglycerol in medium ) and the rates of triacylglycerol synthesis observed with various diacylglycerols were not significantly different when the data were analyzed statistically . | NA | {
"id": "C0043791",
"name": "diacylglycerol",
"pos": [
4,
18
]
} | {
"id": "C0012262",
"name": "diacylglycerols",
"pos": [
230,
245
]
} |
deficiency in methionine or other essential amino acids through a limited feed consumption may have caused a decrease in albumin synthesis . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
14,
24
]
} | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
34,
55
]
} |
the results indicate that inhibition of antibiotic formation by exogenous nucleotides , including cyclic nucleotides , is similar to the effect produced by inorganic phosphate . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
74,
85
]
} | {
"id": "C0028631",
"name": "cyclic",
"pos": [
98,
104
]
} |
the highest total protein ( 43 % ) and nucleic acid ( 5.2 % rna and 0.2 % dna ) concentrations were found in the exponential growth phase ; | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
39,
51
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
74,
77
]
} |
in the presence of k+ , the bimodal plot observed in the absence of citrate gradually changed to a hyperbolic shape as the concentration of citric acid was increased . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
68,
75
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
140,
151
]
} |
when the source of nitrogen is yeast extract or nitrate the ph is around 6.5 and red pigments are formed , whereas with ammonium or ammonium nitrate the ph is around 2.5 and the pigments are orange . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
48,
55
]
} | {
"id": "C0051722",
"name": "ammonium nitrate",
"pos": [
132,
148
]
} |
the albino mutant has lost , besides the pigment , pentose , xylose , and part of galactose and mannose . | NA | {
"id": "C0030894",
"name": "pentose",
"pos": [
51,
58
]
} | {
"id": "C0043375",
"name": "xylose",
"pos": [
61,
67
]
} |
aflatoxin production by a toxigenic strain of aspergillus flavus was greatly reduced by benzoic acid and sodium benzoate in synthetic media . | NA | {
"id": "C0053225",
"name": "benzoic acid",
"pos": [
88,
100
]
} | {
"id": "C0142805",
"name": "sodium benzoate",
"pos": [
105,
120
]
} |
benzoic acid , sodium benzoate , or autoclaving the cell-free extract appear to have respectively blocked or denatured an enzymatic step late in the biosynthetic pathway of aflatoxin b1 . | NA | {
"id": "C0053225",
"name": "benzoic acid",
"pos": [
0,
12
]
} | {
"id": "C0142805",
"name": "sodium benzoate",
"pos": [
15,
30
]
} |
the in vivo fluorescence of the primary accessory pigments in purple bacteria ( carotenoids ) , green bacteria ( bacteriochlorophyll ) , green algae ( chlorophyll ) , and cyanobacteria ( phycocyanin ) was found to be a linear function of cell concentration over three of four orders of magnitude . | NA | {
"id": "C0004638",
"name": "bacteriochlorophyll",
"pos": [
113,
132
]
} | {
"id": "C0008260",
"name": "chlorophyll",
"pos": [
151,
162
]
} |
however , some cells did show characteristics of fibroblasts , endothelial cells , and infrequently , smooth muscle cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
15,
20
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
49,
60
]
} |
levels of bound carbohydrates reflect the sum of all the changes in serum glycoproteins , but primarily changes in the acute-phase proteins ( alpha 1-acid glycoprotein , alpha 1-antitrypsin , haptoglobin , ceruloplasmin ) found in the alpha-globulin fraction of serum . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0029297",
"name": "alpha 1-acid",
"pos": [
142,
154
]
} |
levels of bound carbohydrates reflect the sum of all the changes in serum glycoproteins , but primarily changes in the acute-phase proteins ( alpha 1-acid glycoprotein , alpha 1-antitrypsin , haptoglobin , ceruloplasmin ) found in the alpha-globulin fraction of serum . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
170,
189
]
} |
levels of bound carbohydrates reflect the sum of all the changes in serum glycoproteins , but primarily changes in the acute-phase proteins ( alpha 1-acid glycoprotein , alpha 1-antitrypsin , haptoglobin , ceruloplasmin ) found in the alpha-globulin fraction of serum . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
192,
203
]
} |
levels of bound carbohydrates reflect the sum of all the changes in serum glycoproteins , but primarily changes in the acute-phase proteins ( alpha 1-acid glycoprotein , alpha 1-antitrypsin , haptoglobin , ceruloplasmin ) found in the alpha-globulin fraction of serum . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0007841",
"name": "ceruloplasmin",
"pos": [
206,
219
]
} |
since the carbohydrate moieties of surface membrane glycoproteins are asymmetrically located on the external cell surface , these glycoconjugates are likely candidates for providing cell surfaces with many of their biological properties . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
10,
22
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
130,
145
]
} |
the tumor-specific protein class tnp1 ( molecular weight ca . 44,000 ) shows high affinity for dna while the second class of tumor-specific proteins ( tnp2 ; molecular weight ca . 62,000 ) does not bind to dna . | NA | {
"id": "C0027642",
"name": "tumor",
"pos": [
4,
9
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
140,
148
]
} |
despite its effect on tumor protein synthesis in whole animals , cyanate had little or no effect on cultured cells ( ht-29 ) derived from a human adenocarcinoma of the colon , nor on other malignant cell lines such as hela s3 cells , chick fibroblasts transformed by the rous sarcoma virus , mouse ehrlich ascites tumor cells , or rat novikoff hepatoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
240,
251
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
353,
358
]
} |
there was also a high positive correlation between the cellular polyamine ( spermidine and spermine ) and nucleic acid content ( spermidine : dna equals 0.916 , spermine : dna equals 0.947 , spermidine : rna equals 0.907 , and spermine : rna equals 0.881 ) . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
106,
118
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
172,
175
]
} |
surface characteristics of hef cells were compared to those of cells derived from a primary tumor induced in hamsters following s.c. inoculation of herpes simplex virus type 1-transformed hef cells ( 14-012-8-1 ) and to the surfaces of cells derived from a metastatic tumor to the lung induced by the same cells . | NA | {
"id": "C0016030",
"name": "hef cells",
"pos": [
27,
36
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
306,
311
]
} |
ruffles and blebs were occasionally observed on hef cells and on the primary tumor cells but were not seen on the cells of the metastatic tumor . | NA | {
"id": "C0016030",
"name": "hef cells",
"pos": [
48,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
4-demethoxydaunorubicin was 27 to 100 times more active than was daunorubicin when inhibiting the cloning efficiency of exponential-phase hela cells and , like daunorubicin , was slightly active on early plateau-phase cells . | NA | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
0,
23
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
160,
172
]
} |
dna synthesis in mouse embryo fibroblasts stimulated by fetal calf serum was inhibited equally by the two compounds , although 4-demethoxydaunorubicin was slightly more active than was daunorubicin when inhibiting rna synthesis . | NA | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
127,
150
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
185,
197
]
} |
freeze-thaw preparations of banded rauscher murine leukemia virus markedly suppressed the in vitro cellular-mediated blastogenic response of murine splenic lymphocytes to phytohemagglutinin-p and to allogeneic cells in two-way mixed-leukocyte reaction . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
99,
107
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
199,
215
]
} |
nab i cultures were negative for virus capsid antigen and early antigen and were not affected by treatment with 5-iododeoxyurdine . | NA | {
"id": "C0003342",
"name": "virus",
"pos": [
33,
38
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
64,
71
]
} |
nab ii cultures were positive for virus capsid antigen and early antigen , which increased with 5-iododeoxyuridine treatment . | NA | {
"id": "C0003342",
"name": "virus",
"pos": [
34,
39
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
65,
72
]
} |
the structure of the antitumor agent , dichloro ( 1,2-diaminocyclohexane ) platinum ( ii ) ( nsc-194814 ) , was modified by replacing the chlorides with organic or inorganic anions . | NA | {
"id": "C0008203",
"name": "chlorides",
"pos": [
138,
147
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
174,
180
]
} |
the excitation maximum ( 375 nm ) directly after formaldehyde treatment , however- differs from that of the catecholamines and dopa ( 410 nm ) , but is similar to the excitation maximum displayed by these catechol derivatives at acid ph . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
108,
122
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
127,
131
]
} |
corticotropin and melanotropin producing cells were localized in the adenohypophysis of normal lerots by using antibodies against synthetic corticotropins ( anti beta1-24 acth , anti alpha17-39 acth , anti alpha25-39 acth ) , and melanotropins ( anti alpha msh , anti beta msh ) . | NA | {
"id": "C0026667",
"name": "melanotropins",
"pos": [
230,
243
]
} | {
"id": "C0002302",
"name": "alpha msh",
"pos": [
251,
260
]
} |
corticotropin and melanotropin producing cells were localized in the adenohypophysis of normal lerots by using antibodies against synthetic corticotropins ( anti beta1-24 acth , anti alpha17-39 acth , anti alpha25-39 acth ) , and melanotropins ( anti alpha msh , anti beta msh ) . | NA | {
"id": "C0026667",
"name": "melanotropins",
"pos": [
230,
243
]
} | {
"id": "C0005261",
"name": "beta msh",
"pos": [
268,
276
]
} |
the distribution of nucleic acids within nuclei of epidermal cells in skin from guinea-pig ear was investigated using an indirect enzyme digestion technique to observe both dna and rna , and a direct schiff-thallium reaction technique , to observe dna alone . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
20,
33
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
248,
251
]
} |
nrk cells and many other cultured fibroblasts were found to contain the protease inhibitor , alpha 2 macroglobulin ( alpha 2m ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} |
these inhibition studies suggest that a similarity exists between the p70 proteolytic factor and some serine proteases , such as trypsin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
102,
118
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
129,
136
]
} |
the effects of chlorphentermine and phentermine on certain metabolic parameters associated with development of rat kidney and liver . | NA | {
"id": "C0008283",
"name": "chlorphentermine",
"pos": [
15,
31
]
} | {
"id": "C0031447",
"name": "phentermine",
"pos": [
36,
47
]
} |
however , there were differences in the magnitude of the hemodynamic changes between norepinephrine and epinephrine , as might on the basis of their different pulmonary pharmacologic effects , but the changes were not statistically significant at all times , and more studies are necessary to determine if the differences are real . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
85,
99
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
104,
115
]
} |
atp-mg++ ( 10 mumoles/100 g , iv ) increased the ld50 for salmonella enteritidis lipopolysaccharide ( endotoxin ) in male holtzman rats ( 300 +/- 10 g ) from 1.3 to 6.0 mg/rat . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
81,
99
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
102,
111
]
} |
the globulin fraction is concentrated by ammonium sulfate precipitation , which allows more of the relevant protein to be applied , use of a wider range of total protein concentrations , and higher resolution than is true for previously described methods . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
4,
12
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
162,
169
]
} |
the effects of ph , phosphorylatable acceptor ( 2-amino-2-methyl-1-propanol and diethanolamine ) , 4-nitrophenyl phosphate , magnesium ion , zinc ion , temperature , volume fraction of specimen , and details of initiation of the reaction have been studied , with use of partly purified enzymes from bone , intestine , liver , and placenta , and sera from patients with a predominant characterized isoenzyme . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
286,
293
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
397,
406
]
} |
tobramycin , amikacin , ampicillin , penicillin g , methicillin , carbenicillin , chloramphenicol , clindamycin , and cephalothin did not interfere with the gentamicin assay . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
24,
34
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
37,
49
]
} |
tobramycin , amikacin , ampicillin , penicillin g , methicillin , carbenicillin , chloramphenicol , clindamycin , and cephalothin did not interfere with the gentamicin assay . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
37,
49
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
66,
79
]
} |
calculating the calcium bound per gram of protein in each peak , we found that proteins in the first peak ( alpha2-macroglobulin , igm , haptoglobins ) bind about the same amount of calcium per gram as does albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
79,
87
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
207,
214
]
} |
the proteins of the second peak ( largely igg and iga ) bind less calcium than does albumin , which is the protein accounting for 90 % or more of the third peak . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
84,
91
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
107,
114
]
} |
serum concentrations of lipids and the lipoproteins varied according to the social class of africans . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
24,
30
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
39,
51
]
} |
levels of ige were examined in pairs of serum and synovial fluid of the knee joint in a series of 78 patients with rheumatoid arthritis ( ra ) , reactive synovitis during osteoarthrosis , and after injury . | NA | {
"id": "C0039103",
"name": "synovitis",
"pos": [
154,
163
]
} | {
"id": "C0022408",
"name": "osteoarthrosis",
"pos": [
171,
185
]
} |
twelve acromegalic patients were studied in one or more of three protocols to establish the response of plasma growth hormone ( hgh ) concentraions to ( a ) a single oral test dose of bromocriptine , ( b ) incremental dose therapy from 10 mg/day to 40 mg/day over 4 weeks , and ( c ) sustained therapy with 20 mg/day over a 3 month period . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
111,
125
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
128,
131
]
} |
the major amino acids are one residue each of aspartic and glutamic acids , proline , hydroxyproline and alanine and two residues of glycine , and the carbohydrates are one residue each of glucose , xylose and hexosamine and two residues of mannose . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
105,
112
]
} |
the major amino acids are one residue each of aspartic and glutamic acids , proline , hydroxyproline and alanine and two residues of glycine , and the carbohydrates are one residue each of glucose , xylose and hexosamine and two residues of mannose . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
133,
140
]
} |
the major amino acids are one residue each of aspartic and glutamic acids , proline , hydroxyproline and alanine and two residues of glycine , and the carbohydrates are one residue each of glucose , xylose and hexosamine and two residues of mannose . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
76,
83
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
86,
100
]
} |
carfecillin , the alpha-phenyl ester of carbenicillin , hydrolyses rapidly in the presence of serum or body tissues to liberate carbenicillin but hydrolysis is less rapid in aqueous solution . | NA | {
"id": "C0007241",
"name": "carfecillin",
"pos": [
0,
11
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
128,
141
]
} |
the activity of carfecillin in antibacterial tests in vitro depends upon the extent of hydrolysis to carbenicillin , and in conventional serial dilution tests carfecillin shows an antibacterial spectrum generally similar to that of carbenicillin due to extensive hydrolysis . | NA | {
"id": "C0007241",
"name": "carfecillin",
"pos": [
16,
27
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
232,
245
]
} |
however , in tests in which the extent of hydrolysis is reduced , carfecillin displays lesser activity than carbenicillin against gram-negative bacilli and greater activity against gram-positive cocci . | NA | {
"id": "C0007241",
"name": "carfecillin",
"pos": [
66,
77
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
108,
121
]
} |
in the presence of serum carfecillin is hydrolysed rapidly to carbenicillin and the activity shown is solely that of carbenicillin . | NA | {
"id": "C0007241",
"name": "carfecillin",
"pos": [
25,
36
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
117,
130
]
} |
unlike carbenicillin , carfecillin is well absorbed in mice after oral administration , producing significant carbenicillin blood concentrations and the compound is as effective by the oral route in the treatment of various experimental mouse infections as is parenteral carbenicillin . | NA | {
"id": "C0007241",
"name": "carfecillin",
"pos": [
23,
34
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
271,
284
]
} |
conversely , in situ hybridization using 3h-complementary dna ( cdna ) synthesized from the cytoplasmic poly ( a ) rna of p. eremicus ( comprising a substantial fraction of total messenger rna ) showed that the number of silver grains in the long arms ( euchromatin ) was significantly higher than that in the short arms . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
115,
118
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
179,
192
]
} |
because of the danger of prolonged bacterial excretion under antibiotic treatment in complication-free salmonella enteritis as well as the possible development of resistant salmonella strains , antibiotic treatment of salmonella infections ( other than typhoid or paratyphoid ) should be limited to systemic forms . | NA | {
"id": "C0036114",
"name": "salmonella enteritis",
"pos": [
103,
123
]
} | {
"id": "C0036117",
"name": "salmonella infections",
"pos": [
218,
239
]
} |
because of the danger of prolonged bacterial excretion under antibiotic treatment in complication-free salmonella enteritis as well as the possible development of resistant salmonella strains , antibiotic treatment of salmonella infections ( other than typhoid or paratyphoid ) should be limited to systemic forms . | NA | {
"id": "C0036117",
"name": "salmonella infections",
"pos": [
218,
239
]
} | {
"id": "C0041466",
"name": "typhoid",
"pos": [
268,
275
]
} |
because of the danger of prolonged bacterial excretion under antibiotic treatment in complication-free salmonella enteritis as well as the possible development of resistant salmonella strains , antibiotic treatment of salmonella infections ( other than typhoid or paratyphoid ) should be limited to systemic forms . | NA | {
"id": "C0036117",
"name": "salmonella infections",
"pos": [
218,
239
]
} | {
"id": "C0030528",
"name": "paratyphoid",
"pos": [
264,
275
]
} |
rocket immunoelectrophoresis shows that the completely reduced protein is devoid of native albumin antigenic determinants but that a rapid regain of immunoprecipitability is obtained upon reoxidation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
63,
70
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
91,
98
]
} |
escherichia coli heterogenotes , which produce hybrid molecules between the chimaeric protein repressor-galactosidase and the enzyme beta-galactosidase , were constructed . | NA | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
104,
117
]
} | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
133,
151
]
} |
repressor-galactosidase in which fully active lac repressor is covalently linked to active beta-galactosidase , is an aggregate with a core structure of four beta-galactosidase parts and two peripheral lac repressor dimers . | NA | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
10,
23
]
} | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
158,
176
]
} |
infection of chicken fibroblasts with newcastle-disease virus indicates that cellular inositol is compartmented in at least two pools . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
21,
32
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
77,
85
]
} |
after one hour of incubation of the slices with thrytropin ( 10 mu/ml ) and [ 32p ] phosphate , the specific activity of the 26000-mr protein was increased by a factor of three while no significant change in specific activity was observed in the 1500-mr contractile protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
134,
141
]
} | {
"id": "C0009915",
"name": "contractile protein",
"pos": [
254,
273
]
} |
this points to the occurrence of a heteropolymer containing n-acetylglucosamine and glucosamine in which some of the glucosamine residues are linked to peptides via their amino groups . | NA | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
62,
79
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
117,
128
]
} |
the pharmacokinetics of valproic acid ( vpa ) have been studied in 6 healthy subjects following a single 600 mg dose , and after multiple doses over 12 days ( 1200 mg daily ) of enteric-coated sodium valproate . | NA | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
24,
37
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
193,
209
]
} |
selection in long-term culture of alloreactive t cells , by successive in vitro restimulation with semi-allogeneic cells , results in primed responder cell populations which maintain full proliferative reactivity to allogeneic cells as well as to the t cell mitogens concanavalin a ( con a ) and phytohemagglutinin ( pha ) but are depleted of cells which can effect target cell destruction in either a specific or nonspecific manner . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
104,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
343,
348
]
} |
con a blasts which have reverted , readily proliferate in response to con a or allogeneic stimulator cells but are largely depleted of effector killer cells and pha-responsive cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
79,
89
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
176,
181
]
} |
normal spleen cells of cba mice or fischer rats were cultured with mitogens or allogeneic cells , together with various substances of schistosoma mansoni origin , and thymidine uptake was measured . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
0,
6
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
79,
95
]
} |
gaba and gaba-related drugs such as muscimol , gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
77,
85
]
} |
audiogenic seizure protection by elevated brain gaba concentration in mice : effects of gamma-acetylenic gaba and gamma-vinyl gaba , two irreversible gaba-t inhibitors . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
114,
130
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
150,
154
]
} |
gamma-acetylenic gaba and gamma-vinyl gaba , two catalytic irreversible inhibitors of gaba-transaminase , produce marked and sustained elevations in mouse brain gaba concentrations and protect dba/2 mice against audiogenically induced seizures in a similar dose and time-dependent manner . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
26,
42
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
161,
165
]
} |
the increase in brain gaba concentrations induced by these compounds correlates well with attenuation of audiogenic seizure intensity ( r = 0.991 and 0.962 for gamma-acetylenic and gamma-vinyl gaba respectively ) and with degree of seizure protection ( r = 0.974 and 0.834 ) . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
22,
26
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
181,
197
]
} |
as compared to the soluble enzyme , the immobilized enzyme was considerably more resistant to heat and sulphanilamide action . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
27,
33
]
} | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
40,
58
]
} |
anterior pituitary microinfusions of noradrenaline in the dog causes a significant release of tsh while adrenaline and dopamine do not . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
37,
50
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
104,
114
]
} |
human fetal hemoglobin was more susceptible to methemoglobin formation in the presence of aminophenols than was adult hemoglobin . | NA | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
6,
22
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
118,
128
]
} |
the plot on normal probability paper indicates a second dna fraction which melts at higher temperatures and , consequently , it has a higher gc-content than the bulk of dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
56,
59
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
171,
172
]
} |
adrenaline ( a ) and noradrenaline ( n ) release from the caudal mesenteric ganglion ( cmg ) during preganglionic nerve stimulation is due to acetylcholine action on n -- and m-cholinoreceptors of ganglion 's adrenergic structures ( gas ) and probably , primarily on sif -- cells , whereas during peripheral reflexes of cmg it is related to the excitation of noncholinergic afferent neurons which affect the corresponding receptors of gas . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
21,
34
]
} |
metabolic transformations of progesterone in cultures of granulosa cells from immature hypophysectomized rats treated with diethylstilbestrol were studied in relation to the synergistic action of exogenous androgen and fsh on progestin ( progesterone and 20alpha-dihydroprogesterone ) accumulation . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
29,
41
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
263,
282
]
} |
thyrotropin ( tsh ) secretion from isolated anterior pituitary cells has been studied using the technique of cell column perifusion . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
0,
11
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
44,
62
]
} |
the above results are consistent with the opinion that the hyperglycemia usually observed during the first hours of ami , is related to the acute medical stress and in no way indicates subclinical and/or latent diabetes . | NA | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
59,
72
]
} | {
"id": "C0271650",
"name": "latent diabetes",
"pos": [
204,
219
]
} |
the role of the sympathoadrenomedullary and adrenocortical systems has been assessed by measuring serially the urinary excretion of free adrenaline , noradrenaline and 11-hydroxycorticosteroids in 32 healthy men under two conditions of job stress : piece-work and assembly line . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
150,
163
]
} |
as an initial attempt to explore the molecular basis of this phenomenon , experiments were designed to determine if the rate increase was specific for rrna as opposed to the other species of rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
151,
155
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
191,
194
]
} |
these effects of dob were not so pronounced as the marked depressor effect of isoproterenol ( iso ) and pressor effects of epinephrine ( epi ) , norepinephrine ( ne ) and dopamine ( da ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
145,
159
]
} |
incidences of ventricular extrasystole observed at the maximal dosages of catecholamines , intravenous administration of 300 microgram/kg of dob , 3 of iso , 10 of epi , 10 of ne , and 300 of da , were 1/4 , 1/4 , 4/4 , 4/4 , and 2/4 , respectively . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
74,
88
]
} | {
"id": "C0012963",
"name": "dob",
"pos": [
141,
144
]
} |
incidences of ventricular extrasystole observed at the maximal dosages of catecholamines , intravenous administration of 300 microgram/kg of dob , 3 of iso , 10 of epi , 10 of ne , and 300 of da , were 1/4 , 1/4 , 4/4 , 4/4 , and 2/4 , respectively . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
74,
88
]
} | {
"id": "C0022245",
"name": "iso",
"pos": [
152,
155
]
} |
these experimental results indicate that effects of dob on the blood pressure , heart rate , and several blood components are weaker than other catecholamines . | NA | {
"id": "C0012963",
"name": "dob",
"pos": [
52,
55
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
144,
158
]
} |
scintigraphic visualization of the adrenals is greatly improved after substitution of 131i-19-i-cholesterol by 6beta-131i-iodomethyl-cholesterol which was first seen as a radiochemical impurity during the synthesis of 131i-19-iodocholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
96,
107
]
} | {
"id": "C0000176",
"name": "19-iodocholesterol",
"pos": [
223,
241
]
} |
in order to study the role of cyclic amp in the inhibition by somatostatin of glucose-induced insulin release , the effect of somatostatin on the potentiation by dibutyryl-cyclic amp ( db-camp ) of insulin release from isolated pancreatic islets of rats was examined . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
30,
40
]
} | {
"id": "C0012054",
"name": "dibutyryl-cyclic amp",
"pos": [
162,
182
]
} |
likewise , plasma insulin response to glucose was clearly reduced in adrenalectomized rats , although there was no difference among the two groups in increment of the blood glucose after the glucose load . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
18,
20
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
191,
198
]
} |
the urinary excretions of mestranol , ethynylestradiol , 2-hydroxy-ethynylestradiol and of the total radioactivity were measured within the following 5 days . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
26,
35
]
} | {
"id": "C0015011",
"name": "ethynylestradiol",
"pos": [
67,
83
]
} |
moreover , in the urines of both of these groups the same amounts of radioactive mestranol ( 1.1 % -6.3 % of the urinary radioactivity ) and 2-hydroxy-ethynylestradiol ( 0.9 % -3.9 % of the urinary radioactivity ) were measured . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
81,
90
]
} | {
"id": "C0015011",
"name": "ethynylestradiol",
"pos": [
151,
167
]
} |
both heparan sulfate and galactosamine-containing glycosaminoglycans ( chondroitin sulfate , dermatan sulfate ) are accumulated in the liver , whereas in the other organs ( spleen , kidney , heart , cerebrum , cerebellum ) heparan sulfate is almost the only glycosaminoglycan stored . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
5,
20
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
258,
275
]
} |
subsequent structural modifications , dependent upon the protamine/dna ratio , suggests a mechanism for dna compaction by protamines . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
67,
70
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
126,
127
]
} |
comparison of infarct sizes in cardiogenic shock and nonshock patients confirms the existence of a significant relationship between a larger myocardial infarct and shock . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
31,
48
]
} | {
"id": "C0027051",
"name": "myocardial infarct",
"pos": [
141,
159
]
} |
the latter possibility may be related to other anatomic events , e.g. , bowel infarction , hemorrhage , or possibly right ventricular ischemia , infarction , or dysfunction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
134,
142
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
145,
155
]
} |
a case of granulocytic sarcoma without the peripheral blood findings of myelogenous leukemia is described . | NA | {
"id": "C0152276",
"name": "granulocytic sarcoma",
"pos": [
10,
30
]
} | {
"id": "C0023470",
"name": "myelogenous leukemia",
"pos": [
72,
92
]
} |
pentagastrin or synthetic human gastrin i added to cat plasma can be stored on ice or at 4 degrees c , for periods up to 27 hr without apparent loss of gastrin activity.3 . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
0,
12
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
152,
159
]
} |
between 1 ( 1/2 ) and 13 min after the rapid i.v . injection of pentagastrin in the anaesthetized cat and between 1 ( 1/2 ) and 15 min after the injection of synthetic human gastrin i , there is a rapid reduction of the gastrin concentration in the arterial plasma . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
64,
76
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
220,
227
]
} |
some studies on the thermic phosphorylation of activated nucleoside by phosphate anion and nucleotide anion . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
71,
80
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
102,
107
]
} |
the effect of cocaine and normetanephrine on the overflow of noradrenaline from the isolated blood-perfused cat spleen . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
26,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
61,
74
]
} |
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