text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the benzodiazepines remain the drugs of choice in anxiety states . but when anxiety is accompained by significant depression , doxepin is more effective than chlordiazepoxide or diazepam . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
4,
19
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
158,
174
]
} |
cyclic amp , dbcamp , 8-methylthio-camp , 8-hydroxy-camp and the 6-chloro-8-aminopurine cyclic ribotide analog of camp also displayed steroidogenic activity in the betamethasone-treated rat ; | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
0,
10
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
13,
19
]
} |
extracts of whole pituitary glands were more potent in stimulating these cellular indices than either those of liver or muscle , confirming that the chondrocytes are sensitive to the described mitogen . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
73,
81
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
149,
161
]
} |
reconstituted particles containing cis fatty acids were infectious when tested on wild type pseudomonas bal-31 as well as on the unsaturated fatty acid auxotroph grown in the presence of either cis or trans-palmitoleic acid . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
39,
50
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
129,
151
]
} |
the presence of hla-d-associated ( ia-like ) antibodies during the culture period specifically inhibited the stimulatory capability of lymphocytes possessing the hla-d determinants with which the antisera were apparently reacting , as long as the stimulating cells carried the determinant for which the responding cells were primed . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
45,
55
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
196,
204
]
} |
these antisera , therefore , apparently contain antibodies which are reactive with determinants closely associated or identical to the hla-d determinants and may be human analogues to the mouse ia antigens . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
6,
14
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
48,
58
]
} |
the turnover rate of blood glucose estimated from the decay curve of blood [ 14c ] glucose increased significantly during exercise . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
21,
34
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
83,
90
]
} |
the effect of atrioventricular ( a-v ) conduction of n6-2'-0-dibutyryl cyclic 3',5'-adenosine monophosphate ( dibutyryl cyclic amp ) was investigated in comparison with those of norepinephrine , cyclic 3',5'-adenosine monophosphate ( cyclic amp ) , adenosine-5'-monophosphate ( 5'-amp ) , and adenosine by the use of the isolated , blood-perfused a-v node preparation of the dog . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
110,
130
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
234,
244
]
} |
the effect of atrioventricular ( a-v ) conduction of n6-2'-0-dibutyryl cyclic 3',5'-adenosine monophosphate ( dibutyryl cyclic amp ) was investigated in comparison with those of norepinephrine , cyclic 3',5'-adenosine monophosphate ( cyclic amp ) , adenosine-5'-monophosphate ( 5'-amp ) , and adenosine by the use of the isolated , blood-perfused a-v node preparation of the dog . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
120,
130
]
} | {
"id": "C0001413",
"name": "adenosine-5",
"pos": [
249,
260
]
} |
unlike dibutyryl cyclic amp , cyclic amp ( above 30 nmol ) , 5'-amp and adenosine ( above 1 nmol ) injected into the posterior septal artery prolonged the a-v conduction time in a dose-dependent manner . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
7,
27
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
30,
40
]
} |
the results indicate that dibutyryl cyclic amp has a mode of action on a-v nodal cells which differs distinctly from that of either norepinephrine or cyclic amp , 5'-amp , and adenosine . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
26,
46
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
150,
160
]
} |
although this experimental model is useful to determine the degree of dopaminergic activity of various chemical agents it does not duplicate the motor disorders encountered in parkinsonism which are associated with a decreased concentration of dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
70,
82
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
244,
252
]
} |
the effect of the narcotic antagonists naloxone , naltrexone and nalorphine on spinal cord c-fiber reflexes evoked by electrical stimulation or radiant heat . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
39,
47
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
50,
60
]
} |
these findings that naloxone and naltrexone facilitated these reflexes in doses too small to have non-specific excitatory effects and that nalorphine facilitated the c-fiber reflex at a dose level that is depressant to the flexor reflex in the chronic spinal dog are consistent with a hypothesis that these effects are due to antagonism of a naturally occurring opiate-like inhibitory substance . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
20,
28
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
33,
43
]
} |
it was found that methylation of the hydroxyl groups of norepinephrine or epinephrine in either the 3- or 4-position markedly reduces or abolishes alpha- and beta-activity with the exception of the nictitating membrane of the cat . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
74,
85
]
} |
[ new analogs of papaverine : synthesis , pharmacological and conformational study of benzyl-4-isoquinolines substituted in the 1 or 3 position ] . | NA | {
"id": "C0030350",
"name": "papaverine",
"pos": [
17,
27
]
} | {
"id": "C1257875",
"name": "benzyl",
"pos": [
86,
92
]
} |
condensation of substituted 1-oxo-2-formyl-3-dimethylamino-1h-naphtho [ 2,1-b ] pyrans with hydrazine or monosubstituted hydrazines led to the formation of 11-oxo-8h,11h-naphtho [ 1',2':5,6 ] pyrano [ 2,3-c ] pyrazole derivatives through the intermediate hydrazones and subsequent cyclization . | NA | {
"id": "C0020233",
"name": "hydrazines",
"pos": [
121,
131
]
} | {
"id": "C0020235",
"name": "hydrazones",
"pos": [
255,
265
]
} |
the heavy metals include at least 40 elements but cadmium , lead , and mercury have been most extensively studied . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
4,
16
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
37,
45
]
} |
the heavy metals include at least 40 elements but cadmium , lead , and mercury have been most extensively studied . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
4,
16
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
50,
57
]
} |
the heavy metals include at least 40 elements but cadmium , lead , and mercury have been most extensively studied . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
4,
16
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
60,
64
]
} |
the heavy metals include at least 40 elements but cadmium , lead , and mercury have been most extensively studied . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
4,
16
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
71,
78
]
} |
the activation of mast cells is considered herein in terms of defined physical stimuli that are characterized by urticaria and angioedema . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
113,
122
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
127,
137
]
} |
2 ) blockade of the action of angiotensin ii by infusion of saralasin , a competitive antagonist of angiotensin ii ; | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
60,
69
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
100,
114
]
} |
in addition , during allogeneic cell culture serum proteins with the prealbumin mobility were released into the culture medium and in the control culture of cells from only one donor proteins with the albumin mobility predominated . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
51,
59
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
201,
208
]
} |
the application of elastomer polymers in the prevention and treatment of chronic tissue irritation from dentures is an excellent alternative to the use of hard polymer resins and it is useful for preserving the health of the remaining denture-supporting tissues . | NA | {
"id": "C0013766",
"name": "elastomer",
"pos": [
19,
28
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
160,
167
]
} |
at the same time , it is not the intent of this article to imply that the use of elastomer polymers is the panacea for all prosthodontic problems or that fundamental principles can be neglected . | NA | {
"id": "C0013766",
"name": "elastomer",
"pos": [
81,
90
]
} | {
"id": "C0032521",
"name": "polymers",
"pos": [
91,
99
]
} |
jodm and aodm cells had a reduction in both indices of cell population growth in comparison with age-matched c fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} |
hydrocorticone did not produce a significant change in total protein and collagen synthesis per cell by c fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
96,
100
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
dose-response curver were different for l ( + ) and d ( + ) arginine , and the suppressor effect of glucose on the response to l ( + ) arginine was not detected in the presence of d ( + ) arginine or homoarginine . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
60,
68
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
200,
212
]
} |
the types of myoclonic epilepsy are infantile spasms , myoclonic astatic epilepsy , myoclonic absence , myoclonic epilepsy of childhood , myoclonic epilepsy of adolescence and photomyoclonic epilepsy , the last being subdivided into myoclonic jerks and eyelid myoclonia . | NA | {
"id": "C0014550",
"name": "myoclonic epilepsy",
"pos": [
13,
31
]
} | {
"id": "C0270853",
"name": "myoclonic epilepsy of",
"pos": [
138,
159
]
} |
the types of myoclonic epilepsy are infantile spasms , myoclonic astatic epilepsy , myoclonic absence , myoclonic epilepsy of childhood , myoclonic epilepsy of adolescence and photomyoclonic epilepsy , the last being subdivided into myoclonic jerks and eyelid myoclonia . | NA | {
"id": "C0014550",
"name": "myoclonic epilepsy",
"pos": [
13,
31
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
191,
199
]
} |
sodium valproate appears to be the drug of choice for epilepsies associated with generalized spike-and-wave discharges , myoclonic epilepsies or photosensitive epilepsies , and is of especial value in children and mentally retarded patients because it lacks sedating effects and often induces liveliness . | NA | {
"id": "C0014544",
"name": "epilepsies",
"pos": [
54,
64
]
} | {
"id": "C0014550",
"name": "myoclonic epilepsies",
"pos": [
121,
141
]
} |
superfusion of twelve human taenia coli strips with cholecystokinin ( cck ) ( boots and gih karolinska ) , cck-octapeptide and glucagon at doses of 25 -- 1,000 midu/ml evoked muscular contractions . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
52,
67
]
} | {
"id": "C0037167",
"name": "cck-octapeptide",
"pos": [
107,
122
]
} |
dose-dependent response to acetylcholine ( ach ) ( 0.15 -- 1.0 mug/ml ) was not altered by an underlying contraction induced by cck , cck-octapeptide or glucagon . | NA | {
"id": "C0008328",
"name": "cck",
"pos": [
128,
131
]
} | {
"id": "C0037167",
"name": "cck-octapeptide",
"pos": [
134,
149
]
} |
the muscles ' sensitivity was highest of cck ( boots ) and lowest to cck-octapeptide , and the sigmoid colon was more sensitive than other parts of the bowel to both . | NA | {
"id": "C0008328",
"name": "cck",
"pos": [
41,
44
]
} | {
"id": "C0037167",
"name": "cck-octapeptide",
"pos": [
69,
84
]
} |
tropic effects distal to the duodenum produced by exogenous gastrin and pentagastrin may be results of supranormal levels . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
60,
67
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
72,
84
]
} |
hemobilia was demonstrated by superselective hepatic angiography and bleeding was stopped by intraarterial infusion of epinephrine and propranolol . | NA | {
"id": "C0018994",
"name": "hemobilia",
"pos": [
0,
9
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
69,
77
]
} |
effect of prolonged glucose infusion on total serum fatty acids and free fatty acids in the rat . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
52,
63
]
} | {
"id": "C0015688",
"name": "free fatty",
"pos": [
68,
78
]
} |
this investigation evaluates the effect of prolonged glucose infusion on triglycerides and the composition in total serum fatty acids and free fatty acids in the rat . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
122,
133
]
} | {
"id": "C0015688",
"name": "free fatty",
"pos": [
138,
148
]
} |
chain elongation is depressed in serum free fatty acids and even more in total serum fatty acids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
39,
55
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
85,
96
]
} |
in serum free fatty acids monodesaturation is unaltered whereas it is highly stimulated in total serum fatty acids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
9,
25
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
103,
114
]
} |
effects of cyclic amp and dibutyryl cyclic amp on amino acid transport in the isolated rat ovary . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
11,
21
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
26,
46
]
} |
the identical eeg reaction of mz twins to alcohol loading could not be attributed to more similar blood alcohol concentrations . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
42,
49
]
} | {
"id": "C0684262",
"name": "blood alcohol concentrations",
"pos": [
98,
126
]
} |
sera with positive complement fixing ana compared with non complement fixing ana are characterized by an absolute increase of igg and relative decrease of the complement component c4 . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
19,
29
]
} | {
"id": "C0009516",
"name": "complement component c4",
"pos": [
159,
182
]
} |
radioimmunoassay of the wz polymorphic antigens of normal human colon and their relationship with abh antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
39,
47
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
102,
124
]
} |
newly synthesized immunoglobulin g ( igg ) , iga , and igm were quantitated by liquid scintillation after their isolation by means of affinity chromatography from columns with immunoglobulin class-specific antibodies coupled to sepharose . | NA | {
"id": "C0020852",
"name": "immunoglobulin g",
"pos": [
18,
34
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
176,
196
]
} |
in cell homogenates , ( na+ + k+ ) -sensitive , ouabain-inhibitable atpase comprised an insignificant fraction of the total atpase activity . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
14,
16
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
124,
130
]
} |
igm anti-igg suppressed immune cytolysis when high concentrations of antiviral serum were incubated with the virus-infected cell , but augmented lysis when low concentrations of anti-herpes simplex virus antibody were exposed to the fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
124,
128
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
233,
244
]
} |
a three-way minor antigenic relationship was demonstrated among the virion antigens of jc virus , bk virus , and simian virus 40 by neurtralization and/or hemagglutination inhibition tests . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
18,
27
]
} | {
"id": "C0003342",
"name": "antigens",
"pos": [
75,
83
]
} |
sera from 18 tonsillar carcinoma patients and from 18 matched control subjects were examined for the presence of antibodies to viral capsid antigen ( vca ) , early antigen ( ea ) and nuclear antigen ( ebna ) of eb virus . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
127,
132
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
191,
198
]
} |
sera from 18 tonsillar carcinoma patients and from 18 matched control subjects were examined for the presence of antibodies to viral capsid antigen ( vca ) , early antigen ( ea ) and nuclear antigen ( ebna ) of eb virus . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
140,
147
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
183,
198
]
} |
herpesvirus saimiri ( h. salmiri ) -transformed cells contained both types of viral dna , unique l-dna and highly repetetive h-dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
78,
87
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
127,
130
]
} |
dna from spleen and lymph-node autopsies of two tumor-bearing marmoset monkeys contained 0.14-0.75 % viral l-dna -and 0.115-1.08 % h-dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
101,
106
]
} |
the former sepharose derivative adsorbed alpha-chymotrypsin , trypsin , subtilisin , thermolysin and neutral subtilopeptidase at neutral ph range , and acid proteases such as pepsin and rhizopus niveus protease at ph 3.5-6.5 . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
157,
166
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
202,
210
]
} |
nine out of 24 patients with acute hepatocellular necrosis leading to fulminant hepatic failure showed biochemical evidence of thiamine deficiency early in the course of their illness , probably as a result of inadequate intake of the vitamin . | NA | {
"id": "C0001364",
"name": "acute hepatocellular necrosis",
"pos": [
29,
58
]
} | {
"id": "C0162557",
"name": "fulminant",
"pos": [
70,
79
]
} |
these studies indicate that conversion of thiamine hydrochloride to its biologically active co-enzyme form , thiamine pyrophosphate , is possible even in the presence of severe acute hepatocellular necrosis , and it is suggested that supplements of the vitamin should be included in the routine management of patients with acute hepatic failure . | NA | {
"id": "C0001364",
"name": "acute hepatocellular necrosis",
"pos": [
177,
206
]
} | {
"id": "C0162557",
"name": "acute",
"pos": [
323,
328
]
} |
however , the relative amounts of phospholipids , neutral lipids are free fatty acids in total lipids , and of glyceryl moiety and fatty acids in total lipids and in phospholipid fraction were not significantly altered by the status of dietary vitamin e . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
34,
47
]
} | {
"id": "C0771648",
"name": "phospholipid fraction",
"pos": [
166,
187
]
} |
however , the relative amounts of phospholipids , neutral lipids are free fatty acids in total lipids , and of glyceryl moiety and fatty acids in total lipids and in phospholipid fraction were not significantly altered by the status of dietary vitamin e . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
69,
85
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
131,
142
]
} |
angular pregnancy occurs in the angle of the uterine cavity , while interstitial pregnancy is a true ectopic pregnancy . | NA | {
"id": "C0404867",
"name": "angular pregnancy",
"pos": [
0,
17
]
} | {
"id": "C0032987",
"name": "ectopic pregnancy",
"pos": [
101,
118
]
} |
with chronic block of the remaining bundle branch , the natural pathway of a-v conduction is totally blocked at a critical time during the tachycardias , thus eliminating the reciprocating tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
139,
151
]
} | {
"id": "C0242514",
"name": "reciprocating tachycardia",
"pos": [
175,
200
]
} |
the use of different substrate-inhibitor combinations permits to record the distribution patterns of acetylcholinesterase and pseudocholinesterase , mainly revealed as butyrylcholinesterase activity . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
101,
121
]
} | {
"id": "C0008429",
"name": "pseudocholinesterase",
"pos": [
126,
146
]
} |
in the absence of pyruvate kinase and an active pep : sugar phosphotransferase system the methylglyoxal glycolytic bypass may also function to some extent for the formation of pyruvate during the catabolism of simple hexose sugars . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
54,
59
]
} | {
"id": "C0026492",
"name": "simple",
"pos": [
210,
216
]
} |
in the absence of pyruvate kinase and an active pep : sugar phosphotransferase system the methylglyoxal glycolytic bypass may also function to some extent for the formation of pyruvate during the catabolism of simple hexose sugars . | NA | {
"id": "C0026492",
"name": "simple",
"pos": [
210,
216
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
217,
223
]
} |
the livr locus , which leads to a trans-recessive derepression of branched-chain amino acid transport and periplasmic branched-chain amino acid-binding proteins , is responsible for greatly increased sensitivity toward growth inhibition by leucine , valine , and serine and , as shown previously , for increased sensitivity toward toxicity by branched-chain amino acid analogues , such as 4-azaleucine or 5',5',5'-trifluoroleucine . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
240,
247
]
} | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
343,
368
]
} |
the livr locus , which leads to a trans-recessive derepression of branched-chain amino acid transport and periplasmic branched-chain amino acid-binding proteins , is responsible for greatly increased sensitivity toward growth inhibition by leucine , valine , and serine and , as shown previously , for increased sensitivity toward toxicity by branched-chain amino acid analogues , such as 4-azaleucine or 5',5',5'-trifluoroleucine . | NA | {
"id": "C0042285",
"name": "valine",
"pos": [
250,
256
]
} | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
343,
368
]
} |
the catalase level of bacteroides distasonis ( atcc 8503 , type strain ) varied with the amount of hemin supplied to the medium when the cells were grown in either a prereduced medium containing 0.5 % peptone , 0.5 % yeast extract , and 1 % glucose or in a prereduced , defined heme-deficient medium . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
99,
104
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
278,
282
]
} |
these experimental results show that the stra gene product , the s12 protein of the 30s subunit , is involved in some aspect of protein chain elongation . | NA | {
"id": "C0599220",
"name": "protein",
"pos": [
69,
76
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
128,
135
]
} |
the relative rates of hydrolysis of amylose , soluble starch , amylopectin , and dextrin were 100 , 97 , 92 , and 60 % , respectively ; | NA | {
"id": "C0002732",
"name": "amylose",
"pos": [
36,
43
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
54,
60
]
} |
the relative rates of hydrolysis of amylose , soluble starch , amylopectin , and dextrin were 100 , 97 , 92 , and 60 % , respectively ; | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
54,
60
]
} | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
63,
74
]
} |
however , the enzymes from these isolates differed with respect to their repressibility , the apparent number of isoenzymes , the necessity for mg2 for activity , and the conditions required for their release . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
14,
21
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
113,
123
]
} |
beta-glucosidase of dictyostelium discoideum is inhibited by purines in the following order : adenine greater than adenosine greater than 6-methylaminopurine greater than hypoxanthine greater than inosine greater than purine greater than guanosine . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
94,
101
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
218,
224
]
} |
the main globoside in the spermatozoa was characterized as glc-nacbeta ( 1 leads to 2 ) manbeta ( 1 leads to 3 ) manbeta ( 1 leads to 4 ) glcbeta ( 1 leads to 1 ) -ceramide by partial acid hydrolysis , analysis of its anomeric configuration with chromium trioxide , methylation analysis and enzymatic hydrolysis . | NA | {
"id": "C0017647",
"name": "globoside",
"pos": [
9,
18
]
} | {
"id": "C0007745",
"name": "ceramide",
"pos": [
164,
172
]
} |
in both cases the contents of serine , glycine , and proline were lower and those of helix-favoring amino acids , namely , lysine , tyrosine , and methionine , were higher than those found in other fractions . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
39,
46
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
100,
111
]
} |
preincubation of the enzyme with dna at 37 degrees before adding dye made the dna-enzyme complex partly resistant to the drug . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
21,
27
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
82,
96
]
} |
from the kinetics of rrna labelling with [ 14c ] orotic acid in vivo , the half-lives of cytoplasmic rrna 's of normal and protein-deficient rat livers were determined to be 6.2 and 5.1 days , respectively . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
9,
17
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
75,
85
]
} |
from the electrophoretic patterns of nucleolar rna 's of both groups of rat livers labeled with [ 14c ] orotic acid , the time courses of the specific activities of nucleolar 45s , 32s , and 28s rrna 's were analysed and the half-life of each nucleolar rna in both groups of rat livers was determined . | NA | {
"id": "C0035668",
"name": "rna 's",
"pos": [
47,
53
]
} | {
"id": "C0035701",
"name": "rrna 's",
"pos": [
195,
202
]
} |
during the course of purification , however , the enzyme was found to be separated into 2 major peaks together with minor peaks by column chromatography on cm-sephadex , and one of the major peaks was identified as a binary complex of the enzyme with nadh . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
50,
56
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
224,
231
]
} |
the reaction of phenylglyoxal ( pgo ) , glyoxal ( go ) , and methylglyoxal ( mgo ) with amino acids were investigated at mild ph values at 25 degrees . | NA | {
"id": "C0031478",
"name": "phenylglyoxal",
"pos": [
16,
29
]
} | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
67,
74
]
} |
the reaction of phenylglyoxal ( pgo ) , glyoxal ( go ) , and methylglyoxal ( mgo ) with amino acids were investigated at mild ph values at 25 degrees . | NA | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
22,
29
]
} | {
"id": "C0034338",
"name": "methylglyoxal",
"pos": [
61,
74
]
} |
these reagents were similarly reactive with the guanidinium group of arginine , but pgo appeared to be much less reactive with the epsilone-amino group of lysine than mgo and go . | NA | {
"id": "C0031478",
"name": "pgo",
"pos": [
84,
87
]
} | {
"id": "C0017992",
"name": "go",
"pos": [
175,
177
]
} |
these reagents were similarly reactive with the guanidinium group of arginine , but pgo appeared to be much less reactive with the epsilone-amino group of lysine than mgo and go . | NA | {
"id": "C0034338",
"name": "mgo",
"pos": [
167,
170
]
} | {
"id": "C0017992",
"name": "go",
"pos": [
175,
177
]
} |
the reactivities of phenylglyoxal ( pgo ) , glyoxal ( go ) , and/or methylglyoxal ( mgo ) with several proteins , including ribonuclease a [ ec 3.1.4.22 ] and its derivatives , alpha-chymotrypsin [ ec 3.4.21.1 ] , trypsin [ ec 3.4.21.4 ] , lysozyme [ ec 3.2.1.17 ] , pepsin [ ec 3.4.23.1 ] , rennin [ ec 3.4.23.4 ] , thermolysin , and insulin and its b chain , have been examined . | NA | {
"id": "C0031478",
"name": "phenylglyoxal",
"pos": [
20,
33
]
} | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
74,
81
]
} |
the reactivities of phenylglyoxal ( pgo ) , glyoxal ( go ) , and/or methylglyoxal ( mgo ) with several proteins , including ribonuclease a [ ec 3.1.4.22 ] and its derivatives , alpha-chymotrypsin [ ec 3.4.21.1 ] , trypsin [ ec 3.4.21.4 ] , lysozyme [ ec 3.2.1.17 ] , pepsin [ ec 3.4.23.1 ] , rennin [ ec 3.4.23.4 ] , thermolysin , and insulin and its b chain , have been examined . | NA | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
26,
33
]
} | {
"id": "C0034338",
"name": "methylglyoxal",
"pos": [
68,
81
]
} |
go and mgo also reacted rapidly with arginine residues , but they also reacted with lysine residues to a significant extent . | NA | {
"id": "C0017992",
"name": "go",
"pos": [
0,
2
]
} | {
"id": "C0034338",
"name": "mgo",
"pos": [
7,
10
]
} |
a mass spectrometric method was developed to determine ph-dependent hydrogen-deuterium exchange at the c-2 position of the imidazole ring of histidine , after converting the amino acid to the methylthiohydantoin derivative . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
68,
76
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
77,
86
]
} |
epsilon- ( gamma-glutamyl ) lysine has been found in human stratum corneum in the fraction containing the alpha helical fibrous proteins ( keratins ) and other high molecular weight proteins . | NA | {
"id": "C0036425",
"name": "fibrous proteins",
"pos": [
120,
136
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
182,
190
]
} |
reacting enzyme sedimentation studies have been performed with yeast hexokinase isozymes a and b in the presence and absence of chromium atp at ph 6.75 . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
9,
15
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
80,
88
]
} |
it was demonstrated by circular dichroic spectra that the competitive inhibitor , ethionine , interacts with the holoenzyme in the absence of activating monovalent cations , although it does not undergo labilization of the alpha proton . | NA | {
"id": "C0007449",
"name": "monovalent",
"pos": [
153,
163
]
} | {
"id": "C0033727",
"name": "proton",
"pos": [
229,
235
]
} |
the elastase enzymes consist of a family of five isozymes , and at least three isozymes comprise the chymotrypsin-like enzyme system . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
13,
20
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
79,
87
]
} |
the ability of sarcoplasmic reticulum vesicles to retain calcium following atp-supported calcium uptake in the presence of the calcium-precipitating anions oxalate and phosphate depends on cao ( calcium ion concentration outside the vesicles ) and cai ( calcium ion concentration within the vesicles ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
149,
155
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
168,
177
]
} |
it contains the heme in its cytochrome b5 structure , has no sulfite oxidase activity , and is reducible with dithionite but not with sulfite . | NA | {
"id": "C0012787",
"name": "dithionite",
"pos": [
110,
120
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
134,
141
]
} |
purified tubulin prepared from pig brain in the absence of added guanine nucleotides contains 1 mol each of gdp and gtp/mol of tubulin . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
65,
72
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
108,
111
]
} |
purified tubulin prepared from pig brain in the absence of added guanine nucleotides contains 1 mol each of gdp and gtp/mol of tubulin . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
65,
72
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
116,
119
]
} |
all three populations are rich in phospholipids ( 64.9 to 67.5 % ) and cholesterol ( 23.0 to 26.8 % ) but poor in cholesteryl esters ( 0.4 to 1.9 % ) , triglycerides ( 1.8 to 3.2 % ) , and protein ( 3.2 to 6.7 % ) with differences in chemical composition which result in buoyant densities ( 1.038 , 1.049 , and 1.058 , respectively ) to allow their separation . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
71,
82
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
114,
132
]
} |
the 50 % inhibitory concentrations ( i50 ) of trimethoprim , methotrexate , and aminopterin are increased several thousandfold over the corresponding values for the chromosomal enzyme . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
61,
73
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
80,
91
]
} |
no protein corresponding to the slower-migrating species was detected in the membrane proteins synthesized in vivo . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
3,
10
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
77,
94
]
} |
from these results , it seems possible that this new form of the lipoprotine is a precursor of the lipoprotein ( prolipoprotein ) in the process of biosynthesis and assembly of the lipoprotein in the outer membrane . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
41,
42
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
181,
192
]
} |
the nonglycosylated protein , secreted in the presence of 2-deoxyglucose , was characterized as a nonglycosylated form of k-46 light chain by the following criteria : ( a ) electrophoresis in polyacrylamide gels containing sodium dodecyl sulfate , ( b ) reactivity of the nonglycosylated protein with antisera prepared against native , fully glycosylated , k-46 light chain , ( c ) analysis of the protein by gel filtration techniques , ( d ) behavior of the protein on lectin-derivatized sepharose , and ( e ) analysis of tryptic peptides derived from the protein . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
470,
476
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
557,
564
]
} |
testis activator protein forms a complex with rabbit muscle troponin subunits tni and tnt soluble in low salt . | NA | {
"id": "C0041199",
"name": "complex",
"pos": [
33,
40
]
} | {
"id": "C0077401",
"name": "tni",
"pos": [
78,
81
]
} |
acetolysis of the oligosaccharide with a molecular weight of 1720 released the radioactivity as mannobiose and mannotriose suggesting that these oligosaccharides contain di- and trisaccharide branches linked to the main chain in 1 leads to 6 linkages . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
145,
161
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
178,
191
]
} |
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