text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
nicotinamide production was dramatically increased by l-arginine methyl ester and to a lesser extent by d- or l-arginine , but not by other basic amino acids . | NA | {
"id": "C0003765",
"name": "l-arginine",
"pos": [
54,
64
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
140,
157
]
} |
should a formation of a multilayer of plasma proteins occur following the initial adsorption of a monolayer , this process could be influenced by changes in the solubility of the proteins , especially fibrinogen , the solubility of which is quite low in plasma . | NA | {
"id": "C0034861",
"name": "formation",
"pos": [
9,
18
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
179,
187
]
} |
the avcothane 51 elastomer , a member of a series of proprietary materials best characterized as polyurethane/poly ( dialkylsiloxane ) block copolymers , displays considerable hemocompatibility without any incorporated anticoagulants . | NA | {
"id": "C0013766",
"name": "elastomer",
"pos": [
17,
26
]
} | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
97,
109
]
} |
changes were already detected after twenty-four hours at the cell mitosis level , which showed the sensitiveness of the chondrocyte itself . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
61,
65
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
120,
131
]
} |
we were able to stop the hemorrhage by embolisation and this facilitated surgical removal of the hematoma . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
25,
35
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
97,
105
]
} |
5 ) the extent of the cellular reaction , the enumeration of giant , inflammatory cells and fibroblasts showed superiority of mesh material ; | NA | {
"id": "C0007634",
"name": "the",
"pos": [
4,
7
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} |
6 ) the ratio of fibroblasts/inflammatory cells reflected closely the mechanical resistance and tolerance of the foreign material . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
4,
7
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
17,
28
]
} |
idiopathic edema patients have normal urinary noradrenaline and adrenaline excretions but , as previously observed , elevated : 1 ) plasma renin activity while either recumbent or upright , and 2 ) plasma aldosterone concentrations while upright . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
these results suggest that a decrease in urinary dopamine , a catecholamine recently recognized to have natriuretic action , possibly reflects a suppression of the renal dopaminergic system and may contribute to the excessive sodium retention in idiopathic edema either directly or indirectly through the renin-aldosterone system . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
49,
57
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
170,
182
]
} |
insulin , proinsulin , glucagon and gastrin in pancreatic tumors and in plasma of patients with organic hyperinsulinism . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
10,
20
]
} |
insulin , proinsulin , glucagon and gastrin were determined in extracts of tumors of 27 patients with pancreatic islet cell neoplasia of pancreas , in one patient with nesidioblastosis , in extracts of uninvolved portions of the pancreas in 11 of the tumor patients and of 15 control pancreases . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
10,
20
]
} |
the data indicate : 1 ) insulin-secreting islet cell tumors have decreased storage capacity for insulin , 2 ) elevated concentration of proinsulin in tumors may be due to decreased capacity to store insulin and in some to decreased conversion of proinsulin to insulin as well , 3 ) tolbutamide stimulates the exaggerated release of a relatively constant fraction of insulin stored in adenomas . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
136,
146
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
366,
373
]
} |
4 ) solitary adenomas may contain excess amounts of pancreatic hormones in addition to insulin , 5 ) elevated plasma glucagon in patients with organic hyperinsulinism may indicate malignancy , microadenomatosis or multiple endocrine adenoma syndrome , and 6 ) chronic hyperinsulinism and hypoglycemia due to adenoma do not suppress insulin and proinsulin content of uninvolved pancreas . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
87,
94
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
344,
354
]
} |
finally , during somatostatin infusion the initial elevation of blood sugar after oral glucose , in the absence of insulin response , appeared considerably delayed . | NA | {
"id": "C0005802",
"name": "blood",
"pos": [
64,
69
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
87,
94
]
} |
specimens were inoculated into human diploid fetal tonsil fibroblasts ( ft ) , hela cells with 30 mm mg2+ , and hela cells without increased mg2+ . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
58,
69
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
117,
122
]
} |
one hundred twelve rhinovirus strains ( 83 % ) were reisolated in ft cells , whereas 76 rhinovirus strains ( 56 % ) were recovered in hela cells with 30 mm mg2+ . | NA | {
"id": "C0016030",
"name": "ft cells",
"pos": [
66,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
} |
all strains recovered in ft were the same serotype as that originally recovered in diploid cells , but five of the hela cell isolates ( 3.7 % of total specimens ) were different serotypes , indicating dual rhinovirus infections . | NA | {
"id": "C0016030",
"name": "ft",
"pos": [
25,
27
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
120,
124
]
} |
isolation of rhinovirus in ft cells was usually accomplished at first passage , whereas rhinovirus cytopathic effects in hela cells were not observed at first passage , but required one , two , or ( rarely ) three blind passages . | NA | {
"id": "C0016030",
"name": "ft cells",
"pos": [
27,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
126,
131
]
} |
however , three serotypes , types 16 , 36 , and 58 , were recovered as effectively in hela cells , with or without added mg2+ , as they were in ft cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C0016030",
"name": "ft",
"pos": [
144,
146
]
} |
moreover , pgs abolished aggregation of platelets by polylysine but did not prevent aggregation by adp , suggesting that pgs may block strategically placed lysine sites on the collagen molecule . | NA | {
"id": "C0032518",
"name": "polylysine",
"pos": [
53,
63
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
156,
162
]
} |
endothelial cells also inactivate longer analogs of bradykinin , such as kallidin , methionyl-lysyl bradykinin , and bradykinin coupled covalently to 500,000 mol wt dextran . | NA | {
"id": "C0022474",
"name": "lysyl bradykinin",
"pos": [
94,
110
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
117,
127
]
} |
the guanosine 5'-triphosphate analogue , 5'-guanylyl-imidodiphosphate , produced about a threefold enhancement of basal and parathyroid hormone-stimulated enzyme activities under standard conditions ( 5 mm mg+2 , 1mm atp , ph 8.0 , 30 degrees c ) . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
4,
13
]
} | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
44,
69
]
} |
the distinctive histological features of these neoplasms and the means of differentiating them from anaplastic carcinomas and certain other carcinomas , for example , islet cell carcinoma , oat cell carcinomas , and carcinoid tumours , are discussed . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
111,
121
]
} | {
"id": "C0262584",
"name": "oat cell carcinomas",
"pos": [
190,
209
]
} |
the findings suggest that persistent activation of the adenylate cyclase is due to persistent binding of gpp ( nh ) p to the regulatory site , and that this gtp analog is a better activator of the adenylate cyclase than gtp because of its resistance to hydrolysis . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
105,
117
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
220,
223
]
} |
in the presence of sodium azide , sodium nitroprusside or hydroxylamine , magnesium ion was as effective as manganese ion as a sole cation cofactor for guanylate cyclase . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
84,
87
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
132,
138
]
} |
in contrast , the activities of na , k-atpase , protein kinase , phosphorylase kinase , glycogen synthetase and a number of glycosidases were not altered by equipotent amounts of the inhibitor . | NA | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
48,
62
]
} | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
65,
85
]
} |
experiments with immunoglobulin class-specific anti-mouse antisera , in solution and by radioimmunoelectrophoresis , showed that the antibodies were heterogeneous , but were predominantly of the igg class . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
58,
66
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
133,
143
]
} |
the lipid a moiety of bacterial lipopolysaccharide ( lps ) elicits several types of responses in murine b lymphocytes . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
4,
11
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
32,
50
]
} |
these two cell populations can be distinguished by their different phagocytic properties and morphologic appearance , their requirement for antibody in the adcc reaction , and the rapidity with which they lyse target cells in the presence of immune serum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
140,
148
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
242,
254
]
} |
thus , treatment of ysm with neuraminidase , beta-galactosidase , mixed glycosidases , as well as oxidation of ysm with periodate all are without effect on its capacity to bind iggr . | NA | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
29,
42
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
72,
84
]
} |
a series of cross-reacting serum albumins was used for a study of the specificity of the antibody and dth responses to bsa . | NA | {
"id": "C0036773",
"name": "serum albumins",
"pos": [
27,
41
]
} | {
"id": "C0036774",
"name": "bsa",
"pos": [
119,
122
]
} |
spleen cells obtained 3 and 5 days after infection also exerted cytotoxicity against uninfected fibroblasts , but by the 7th day there was little or no reactivity against uninfected target cells , although activity against infected fibroblasts was maximal at this time . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
232,
243
]
} |
when spleen cells were obtained 7 days after infection , the coxsackievirus-immune population was not cytotoxic for vaccinia-infected fibroblasts , and the vaccinia-immune population was not cytotoxic for coxsackievirus-infected targets , although each immune cell preparation caused significant lysis of fibroblasts infected with the homologous virus . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
305,
316
]
} |
secretion of csf from lps-stimulated spleen cells coincided with cellualr dna synthesis and cell transformation and both activities could be attributed to the lipid a moiety of the molecule . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
22,
25
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
159,
166
]
} |
after removal of adherent spleen cells , the remaining splenic lymphocytes were specifically cytotoxic for the immunizing tumor and showed no cross-reactivity with other syngeneic uv-induced or methylcholanthrene-induced tumors of similar histologic type . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
122,
127
]
} | {
"id": "C0027652",
"name": "tumors of",
"pos": [
221,
230
]
} |
the assay furnishes information on the avidity , specificity and immunoglobulin class of experimental or pathological anticollagen antibodies . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
65,
85
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} |
saponin and aluminium hydroxide were compared as adjuvants for promoting serum reagins in cattle using bhk cell lysate as allergen and the passive cutaneous anaphylaxis test to demonstrate the antibodies . | NA | {
"id": "C0034761",
"name": "reagins",
"pos": [
79,
86
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
193,
203
]
} |
studies of antinuclear antibodies ( ana ) were carried out in 39 cases of systemic scleroderma and for comparison in 19 cases of systemic lupus erythematosus ( sle ) and 4 of mixed connective tissue disease ( mctd ) using indirect immunofluorescence ( if ) methods under standard conditions . | NA | {
"id": "C0036421",
"name": "systemic",
"pos": [
74,
82
]
} | {
"id": "C0009782",
"name": "of",
"pos": [
236,
238
]
} |
using a sensitive new assay , we have measured the cholesteryl ester and cholesterol contents of stratum corneum from callus , normal skin , psoriatic lesions ( plantar and nonplantar ) , and lamellar ichthyotic lesions ( plantar and nonplantar ) . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
51,
68
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
73,
84
]
} |
in the anti-ea-positive group , 19 specimens of serum contained ebv-igm , 16 contained elevated titers of antibodies to vca , and 20 contained antibodies to ebvna . | NA | {
"id": "C0003320",
"name": "ea",
"pos": [
12,
14
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
120,
123
]
} |
the primary bile acid , chenodeoxycholic acid , and the secondary bile acid , deoxycholic acid , when present at a concentration of greater than 3 mm , induce salt and water secretion from the human colon and cause a marked increase in the permeability of the human colon to molecules of a molecular weight of 200-500 daltons . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
24,
45
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
78,
94
]
} |
there was no significant difference between mortality rates when patients were grouped by anticipated clinical course of underlying disease ( nonfatal , ultimately fatal , and rapidly fatal ) and when they were grouped by type of antibacterial therapy ( appropriate , including clindamycin , chloramphenicol , lincomycin , and carbenicillin ; or inappropriate , signifying no antibiotic treatment or treatment with antibiotics other than the four listed above ) . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
278,
289
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
310,
320
]
} |
tobramycin , sisomicin , and amikacin were compared with gentamicin in the therapy of experimental e. coli meningitis in rabbits . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
13,
22
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
57,
67
]
} |
the mean percent penetration ( csf conc./serum conc . x 100 % ) with the three dosages was 10 to 50 % for gentamicin , 8 to 23 % for tobramycin , 6 to 16 % for sisomicin , and 11 to 23 % for amikacin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
106,
116
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
160,
169
]
} |
mean csf bacterial titers decreased 3.07 logs in rabbits treated with sisomicin and 2.44 logs in animals treated with gentamicin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
70,
79
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
118,
128
]
} |
during the first 2 hours of therapy csf titers declined 1.02 logs in animals treated with sisomicin as compared to 0.37 log in animals receiving gentamicin even though gentamicin concentrations were higher ( mean 7.4 vs. 4.1 gm./ml . ) . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
90,
99
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
168,
178
]
} |
plasma concentrations of progesterone , 17alpha-hydroxyprogesterone , and 21-deoxycortisol in the cah patients were increased 10 to 100-fold . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
25,
37
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
40,
67
]
} |
thus while oral contraceptive-induced depression of antithrombin iii could possibly predispose to thrombosis by diminishing the inhibition of the serine protease clotting factors , the concomitant decreased level of plasmin inhibition might balance the system by favoring thrombolysis as well as the digestion and inactivation of certain clotting factors by plasmin . | NA | {
"id": "C0036734",
"name": "serine",
"pos": [
146,
152
]
} | {
"id": "C0016016",
"name": "plasmin",
"pos": [
358,
365
]
} |
trauma induced by fracture and periosteal damage was followed by a local hemopoietic response in both normal and osteosclerotic mice . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
0,
6
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
18,
26
]
} |
these studies indicate that trauma induced by fracture and periosteal damage is followed by a fairly uniform local hemopoietic regenerative response regardless of whether or not marrow is present in the traumatized bone . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
28,
34
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
46,
54
]
} |
for both albumin and fibrinogen a much reduced ct : protein ratio was required before satisfactory in vivo proteins were obtained . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
9,
16
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
107,
115
]
} |
feeding rabbits 500 mg of cholesterol daily for 4 to 15 days greatly increased the concentration of esterified cholesterol in lipoproteins of d less than 1.006 g/ml . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
26,
37
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
100,
122
]
} |
although the fatty acid composition of the basal diet was different from the diets supplemented with either hydrogenated fat containing trans-fatty acid or beef tallow containing all cis , the lipid and fatty acid compositions of each of the isolated lipoprotein classes for the four groups of animals were remarkably similar . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
193,
198
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
251,
262
]
} |
homogenates of cultured hamster fibroblasts ( bhk 21 cells ) were fractionated by differential centrifugation into six main fractions : nuclear , mitochondrial , light mitochondrial , microsomal , soluble , and floating . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
53,
58
]
} |
the results of reduction of tongue size in connection with orthodontic and surgical correction of prognathic anomalies of the jaws are presented . | NA | {
"id": "C0033324",
"name": "prognathic",
"pos": [
98,
108
]
} | {
"id": "C0022360",
"name": "anomalies",
"pos": [
109,
118
]
} |
in teleosts the head region , particularly the gills , plays the key role in osmoregulatory nacl transport , presumably by mechanisms located in the chloride cell . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
92,
96
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
149,
157
]
} |
a neutral sodium chloride carrier is postulated that is energized by the movement of sodium from extracellular fluid down its electrochemical gradient into the chloride cell . | NA | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
10,
25
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
160,
168
]
} |
anion conductance sequence and permeability sequence were both determined to be cl-greater than br-greater than or equal to i-greater than ch3so4- . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
0,
5
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
124,
125
]
} |
the bearing of our findings on two inborn errors of amino acid metabolism , maple-syrup-urine disease and hypervalinaemia , is discussed . | NA | {
"id": "C0002514",
"name": "inborn errors of amino acid metabolism",
"pos": [
35,
73
]
} | {
"id": "C0024776",
"name": "maple-syrup-urine disease",
"pos": [
76,
101
]
} |
effects of cyclic amp and dibutyryl cyclic amp on cerebral hemodynamics and metabolism in the baboon . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
11,
21
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
26,
46
]
} |
zinc deficient rats demonstrate an increased intake of sodium chloride ( nacl ) containing solutions as compared to normal rats , presumably related to decreased taste acuity . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
62,
70
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
73,
77
]
} |
if the availability of essential amino acids to the mammary gland , per se , was limiting the synthesis of milk protein , methionine , lysine and phenylalanine may have been the three amino acids most limiting . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
23,
44
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
122,
132
]
} |
the patient sustained an injury in the middle third of his face that involved loss of the anterior portion of the maxilla , the alveolus from the right molar to the left premolar region , and the anterior two thirds of the hard palate with comminuted fractures of the adjacent bones . | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
240,
250
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
251,
260
]
} |
the major lipids of normal duckling plasma were phosphatidylcholine ( 33 % ) , triacylglycerols ( 22 % ) , cholesterol esters ( 20 % ) , cholesterol ( 12 % ) , phosphatidylethanolamine ( 5 % ) , and sphingomyelin ( 2 % ) . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
107,
125
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
137,
148
]
} |
infection of ducklings with p. lophurae caused increases in plasma unesterified fatty acids , triacylglycerols and cholesterol esters , and a notable rise in the 18:1 content of all fatty acid-containing plasma neutral lipids . | NA | {
"id": "C0015688",
"name": "unesterified fatty acids",
"pos": [
67,
91
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
182,
192
]
} |
the results show erythrosine to be approximately twice as toxic as sodium fluorescein with ld50 values of 2558 +/- 1.35 mg/kg in mice and 2891 +/- 1.02 mg/kg in rats for erythrosine and 4738 +/- 1.23 mg/kg in mice and 6721 +/- 1.26 mg/kg in rats for sodium fluorescein . | NA | {
"id": "C0060520",
"name": "fluorescein",
"pos": [
74,
85
]
} | {
"id": "C0147866",
"name": "sodium fluorescein",
"pos": [
250,
268
]
} |
adolescent males and females were significantly more likely to obtain more anxiety signs than the two adult groups , although young adults and middle-aged adults did not differ from one another in hfd performance . | NA | {
"id": "C0001675",
"name": "adult",
"pos": [
102,
107
]
} | {
"id": "C0683973",
"name": "middle-aged",
"pos": [
143,
154
]
} |
the effect of adding anionic ( sodium dodecyl sulphate ) cationic ( dodecyl trimethyl bromide ) and non-ionic ( polyoxyethylene glycol monoethers of hexadecanol ) surface-active agents , and mixtures of these ionic and non-ionic species , on the electrophoretic properties of the drug dispersions has been measured . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
21,
28
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
86,
93
]
} |
the effect of adding anionic ( sodium dodecyl sulphate ) cationic ( dodecyl trimethyl bromide ) and non-ionic ( polyoxyethylene glycol monoethers of hexadecanol ) surface-active agents , and mixtures of these ionic and non-ionic species , on the electrophoretic properties of the drug dispersions has been measured . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
21,
28
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
223,
228
]
} |
the effect of adding anionic ( sodium dodecyl sulphate ) cationic ( dodecyl trimethyl bromide ) and non-ionic ( polyoxyethylene glycol monoethers of hexadecanol ) surface-active agents , and mixtures of these ionic and non-ionic species , on the electrophoretic properties of the drug dispersions has been measured . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
57,
65
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
223,
228
]
} |
fasting and nonfasting blood ethanol concentrations following repeated oral administration of ethanol to one adult male subject . | NA | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
23,
51
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
94,
101
]
} |
a total of 73 % of the dose in the solution was absorbed as beta-methyldigoxin and digoxin . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
60,
78
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
83,
90
]
} |
orally administered beta-methyldigoxin solution delivered 97 % cardioactivity as itself and digoxin with respect to an equivalent amount of intravenously administered digoxin . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
20,
38
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
167,
174
]
} |
this value contrasts to the 140 % delivered by intravenously administered beta-methyldigoxin on the premise of pharmacodynamic equivalence of systemically appearing digoxin and beta-methyl-digoxin . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
74,
92
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
189,
196
]
} |
literature reports on the oral bioavailability of solutions and solid dosage forms of digoxin were critically reviewed , but no reliable comparison of the extent and reproducibility of oral absorption of cardioactive agents from administered digoxin or beta-methyldigoxin could be made from the widely variable digoxin studies with nonspecific assays . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
253,
271
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
311,
318
]
} |
the time course of this action correlated with the time course of beta-methyldigoxin and its active metabolite , digoxin , in their deepest pharmacokinetic compartments and not with their plasma levels . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
66,
84
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
113,
120
]
} |
the time course of heart rate action correlated ( 8.3 and 12.5 % decreases with 0.3 and 0.6 mg iv , respectively ; 6.5 and 9.5 % decreases with 0.3 and 0.6 mg po , respectively ) with the time course of beta-methyldigoxin and its metabolite digoxin in shallower pharmacokinetic compartments ( peaks at approximately 80 min intravenously and 135 min orally ) , and significant effects had disappeared by 10 hr after drug administration . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
203,
221
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
241,
248
]
} |
separate powdered mixtures of aspirin usp with gluconolactone , anhydrous lactose , spray-dried lactose , mannitol , and sorbitol were stored at various humidities and temperatures for specified periods and tested for the integrity of aspirin . | NA | {
"id": "C1572745",
"name": "anhydrous lactose",
"pos": [
64,
81
]
} | {
"id": "C0022949",
"name": "lactose",
"pos": [
96,
103
]
} |
a glc method for the determination of the opium alkaloids in papaveretum , based on the formation of the acetyl derivatives of morphine and codeine , is described . | NA | {
"id": "C0026553",
"name": "derivatives",
"pos": [
112,
123
]
} | {
"id": "C0009214",
"name": "codeine",
"pos": [
140,
147
]
} |
the kinetics of various oxymorphones , their 6-methylene analogs and the 6-hydroxy-epimers corresponding to naloxone and naltrexone have been studied in the longitudinal muscle strip of the guinea-pig ileum . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
108,
116
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
121,
131
]
} |
the alpha-orientation of the hydroxy group at c-6 enhanced the agonistic property of both naloxone and naltrexone . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
90,
98
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
103,
113
]
} |
involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
128,
136
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
151,
163
]
} |
mg++ atpase was about 10-fold less sensitive to inhibition by cd than na+ +k+ atpase . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
5,
11
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
70,
72
]
} |
in the two areas in which a time course of the response was determined , the caudate nucleus and cerebral cortex , cgmp depletion was maximal 1 hour after ethanol administration when blood ethanol concentrations were highest . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
155,
162
]
} | {
"id": "C0684262",
"name": "blood",
"pos": [
183,
188
]
} |
in all experiments , gentamicin was administered as gentamicin sulfate at 100 mg/kg b.wt . per day for 2 days ; | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
21,
31
]
} | {
"id": "C0546866",
"name": "gentamicin sulfate",
"pos": [
52,
70
]
} |
the passage of fatty acids across the placenta was studied in 28 day pregnant rabbits ( i ) by comparing the fatty acid distribution in plasma free fatty acids ( ffa ) of umbilical cord artery and vein with that in maternal plasma and ( ii ) by infusing the doe at a constant rate with labelled palmitic , linoleic or arachidonic acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
15,
25
]
} | {
"id": "C0015688",
"name": "fatty",
"pos": [
148,
153
]
} |
the mean levels of all the fatty acids studied ( from twelve to twenty carbon atoms ) were similar in both the umbilical vein plasma and maternal arterial plasma ffa , except for arachidonic acid , which was higher in foetal blood . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
27,
38
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
162,
165
]
} |
during the constant infusion experiments the specific activities of the fatty acids in the maternal and foetal circulating ffa pools rose rapidly during the first 4 min then rose only slowly . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
72,
83
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
123,
126
]
} |
in normal conditions adrenaline and noradrenaline in a concentration of 10 ( -5 ) g/ml. , and histamine in a concentration of 10 ( -6 ) g/ml. , prolonged the duration of the plateau of the action potential and increased the amplitude and duration of the phasic contraction . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
21,
31
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} |
the results are interpreted to indicate an early inhibitory action of cytochalasin b on the active transcellular pump mechanism and to suggest a cytochalasin b-mediated progressive increase in cell membrane permeability to sodium resulting ultimately in a highly leaky epithelium . | NA | {
"id": "C0010737",
"name": "cytochalasin b",
"pos": [
70,
84
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
145,
157
]
} |
for all parameters measured in the laboratory , thermocraft , a precious alloy , proved to be the most satisfactory- wiron s , a nonprecious alloy , was comparable to degudent universal , a gold alloy . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
73,
78
]
} | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
190,
200
]
} |
equipment , investment , and casting techniques , all designed for the casting of gold alloys , were also used for the nonprecious alloys . | NA | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
82,
93
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
131,
137
]
} |
increases in the specific radioactivity of lipid extracts from washed spermatozoa lent support to the contention that lipoproteins become firmly bound to the cells . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
43,
48
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
118,
130
]
} |
the specificity of this experimental tumor system apparently requires esters of ( - ) -cephalotaxine for tumor inhibition because methyl cephalotaxylitaconate ( 7b ) prepared from the synthetic ( + ) enantiomer of cephalotaxine is inactive . | NA | {
"id": "C0027659",
"name": "experimental tumor",
"pos": [
24,
42
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
105,
110
]
} |
these results are discussed in terms of possible end product regulation of polyamine biosynthesis and the possible substitution of the nucleoside antibiotic , tubercidin , for adenosine in reactions involving s-adenosylmethionine and its metabolites . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
176,
185
]
} | {
"id": "C0036002",
"name": "s-adenosylmethionine",
"pos": [
209,
229
]
} |
norleucine , norvaline , methionine , valine , serine , glutamine , phenylalanine , glutamic acid , proline , and lysine analogues gave , in that order , decreasing activity . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
56,
65
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
84,
97
]
} |
some natural amino acid-zinc sulfate mixtures ( those with lysine , cysteine , glycine , and histidine ) produced greater levels than the equivalent dose of zinc sulfate alone . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
13,
23
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
79,
86
]
} |
net k movements in reconstituted human red cell ghosts and the resealing of ghosts to cations after osmotic hemolysis of red cells have been studied as functions of the free ca ion concentration . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
86,
93
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
191,
194
]
} |
in two-cation symmetrical mixtures the conductance as a function of mole fraction is shown to have a minimum , and the related phenomenon of inhibition and block exerted by one ion on the other is explained explicitly by the theory . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
7,
13
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
177,
180
]
} |
we studied the relationship of histologic features to survival in a population of 132 children with cerebellar gliomas ( excluding medulloblastomas ) . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
111,
118
]
} | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
131,
147
]
} |
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