text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
gastritis and gastric , as well as duodenal , ulcer did not influence the reactivity of patients ' leukocytes , but considerable sensitization was found in patients with atrophic gastritis or intestinalization . | NA | {
"id": "C0017152",
"name": "gastritis",
"pos": [
0,
9
]
} | {
"id": "C0017154",
"name": "atrophic gastritis",
"pos": [
170,
188
]
} |
when classified in the usual manner , i.e. , by considering the reaction with individual tumor extracts , the specificity and the sensitivity of the test was markedly diminished : more false negative determinations were found in the group of gastric cancer patients , and the percentage of false positives in the group of nonmalignant diseases increased . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
89,
94
]
} | {
"id": "C0032927",
"name": "nonmalignant diseases",
"pos": [
322,
343
]
} |
reversal by vitamin a analogues ( retinoids ) of hyperplasia induced by n-methyl-n'-nitro-n-nitrosoguanidine in mouse prostate organ cultures . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
12,
21
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
34,
43
]
} |
furthermore , a strong similarity was seen between the mouse antibody reaction on various mt and the fluorescence pattern of rabbit anti-iap antiserum on these tumors . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
61,
69
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
141,
150
]
} |
male albino mice in groups of eight were each given single doses , either by gavage or by intraperitoneal injection , of either technical chlordane ( 50 or 100 mg/kg ) , hcs-3260 ( 50 or 100 mg/kg ) , or heptachlor : heptachlor epoxide ( 25:75 ) ( 7.5 or 15 mg/kg ) . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
204,
214
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
217,
235
]
} |
whether the protective effect of cyanate on hypoxic hypoxia-induced lethality is due to the increase in hemoglobin-oxygen affinity or attributable to a non-hemoglobin-related action of cyanate remains unresolved . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
104,
114
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
196,
197
]
} |
the only lesion found at necropsy that could be attributed to patulin administration was gaseous distention of the gastrointestinal tract , which was probably the result of the antibiotic effect of this mycotoxin on the normal intestinal flora . | NA | {
"id": "C0030710",
"name": "patulin",
"pos": [
62,
69
]
} | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
203,
212
]
} |
incidence of bacterial pathogens was significantly higher in children below two years and intestinal parasites were three times more common in older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
61,
69
]
} | {
"id": "C1455726",
"name": "older",
"pos": [
143,
148
]
} |
certain viral proteins encoded by the mutant strains , usually the putative mutant protein for the assigned complementation group , were shown to be degraded more rapidly at the nonpermissive temperature than were the wild-type proteins . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
8,
22
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
228,
236
]
} |
certain viral proteins encoded by the mutant strains , usually the putative mutant protein for the assigned complementation group , were shown to be degraded more rapidly at the nonpermissive temperature than were the wild-type proteins . | NA | {
"id": "C1564139",
"name": "mutant",
"pos": [
38,
44
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
228,
236
]
} |
this technique permitted the identification of the p2 protein , the nucleoprotein , and the m protein as the defective gene products in mutant groups ii , v , and vii , respectively . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
54,
61
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
68,
81
]
} |
based on the physiological behavior of mutants in groups ii and v , it appears that p2 protein and nucleoprotein are required for virion rna synthesis during influenza virus replication . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
87,
94
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
99,
112
]
} |
single-stranded dna was observed to depend on a functional dna polymerase iii for infectivity in polab cells , whereas transfection with native t7 dna was independent of the host dna polymerases . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
0,
19
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
179,
182
]
} |
it is suggested that the aldosterone response to sodium restriction is mediated not only by increased plasma renin activity and angiotensin ii concentration , but also another mechanism , possibly related to increased adrenal sensitivity to angiotensin during sodium depletion . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
128,
142
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
241,
252
]
} |
on the luminal cell side , both cyclic amp and dibutyryl cyclic amp inhibited jv in a similar dose-dependent behavior . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
32,
42
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
47,
67
]
} |
deoxy cyclic amp , 5 ' amp , cyclic guanosine monophosphate ( cyclic gmp ) , dibutyryl cyclic gmp had no effect . | NA | {
"id": "C0018338",
"name": "cyclic guanosine",
"pos": [
29,
45
]
} | {
"id": "C0012055",
"name": "dibutyryl cyclic gmp",
"pos": [
77,
97
]
} |
on days six and twelve , the angiotensin ii inhibitor , sar1-ala8-angiotensin ii ( saralasin ) , was infused i.v . and the blood pressure monitored with the subjects first in supine and then in upright position . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
29,
43
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
83,
92
]
} |
nevertheless , the course of the disease may be progressive and fatal , but spontaneous remissions and subsequent relapses have also been essential part of the therapeutic strategy . | NA | {
"id": "C0242656",
"name": "course of",
"pos": [
19,
28
]
} | {
"id": "C0035053",
"name": "spontaneous remissions",
"pos": [
76,
98
]
} |
the effect of prior hypertension on the in vitro incorporation of [ 1-14c ] -oleate into phospholipid and cholesterol ester in aortae from cholesterol-fed and normal fed rabbits was studied . | NA | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
106,
123
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
139,
150
]
} |
the alpha and non-alpha globins of rhesus monkey hemoglobins showed similar electrophoretic mobilities as those of human hemoglobin a by cellulose acetate membrane electrophoresis . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
49,
60
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
121,
133
]
} |
it appeared that the rhesus monkey hemoglobin system is a good model system for the study of human hemoglobin development . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
35,
45
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
96,
97
]
} |
treatment periods of 3 to 7 weeks consisted of penicillin g or ampicillin plus aminoglycoside in nine patients and ampicillin alone in five . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
47,
59
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
115,
125
]
} |
it is concluded that the decrease in cell-free protein synthesis is due to a general decrease in the synthesis of all types of proteins rather than a decrease in a specific group or groups of proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
55,
64
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
192,
200
]
} |
about 40 % of the lipids of the egg wax of boophilus microplus are nonpolar and comprise hydrocarbons ( 10 % ) and wax esters ( 90 % ) . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
18,
24
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
115,
118
]
} |
glioblastomas ( 11 samples ) , astrocytomas ( 4 samples ) , an acoustic neurinoma , an oligodendroglioma , and a meningioma were analyzed . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
0,
13
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
31,
43
]
} |
the effects of original and randomized rapseed oils containing high or very low levels of erucic acid on cardiac lipids and myocardial lesions in rats . | NA | {
"id": "C0028908",
"name": "oils",
"pos": [
47,
51
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
113,
119
]
} |
cholesteryl esters prepared from the fatty acid methyl esters of linseed oil , pig liver lipids , and japanese anchory oil have been separated on the basis of their chain lengths and number of double bonds by gas liquid chromatography on a cyanosiloxane silar 10c column . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
89,
95
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
119,
122
]
} |
of the two antibodies studied under the same in vitro conditions , i.e. , rabbit antisera preparations against rat liver microsomal hydrophilic parts of cytochrome b5 and nadph-cytochrome c reductase , only the antibody against cytochrome b5 demonstrated a marked ability to inhibit the delta6-desaturase activity . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
81,
89
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
211,
219
]
} |
analysis of the sterols of the milkweed bug , oncopeltus fasciatus ( dallas ) and dietary sunflowerseeds revealed that there is little , if any , conversion of dietary c28 or c29 phytosterols to cholesterol in this phytophagous insect . | NA | {
"id": "C0038323",
"name": "sterols",
"pos": [
16,
23
]
} | {
"id": "C0031866",
"name": "phytosterols",
"pos": [
179,
191
]
} |
except for seven patients with large intact baker 's cysts , the ptp syndrome was associated with synovial cyst dissection ( 18 patients ) , rupture ( 5 patients ) , or both ( 4 patients ) . | NA | {
"id": "C0032650",
"name": "baker 's cysts",
"pos": [
44,
58
]
} | {
"id": "C0085648",
"name": "synovial cyst",
"pos": [
98,
111
]
} |
cord blood lipoproteins were quantitated in 117 neonates ( 58 white , 50 black ) to assess for potential early expression of racial lipid distinctions . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
11,
23
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
132,
137
]
} |
thyrotropin or dibutyryl camp increased thyroxine secretion several-fold . l-epinephrine and l-norepinephrine strongly inhibited this stimulated release ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
77,
88
]
} | {
"id": "C0028351",
"name": "l-norepinephrine",
"pos": [
93,
109
]
} |
labeled chylomicrons in thoracic duct lymph were collected after test meals containing 14c cholesterol and 2-3h glyceryl trioleate and were given by intravenous injection to groups of control rats , rats made diabetic by treatment with streptozotocin , and rats made hypothyroid and hypercholesterolemic by a diet containing cholesterol , peanut oil , cholic acid , and thiouracil . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
91,
102
]
} | {
"id": "C0008395",
"name": "diet",
"pos": [
309,
313
]
} |
the recent work on proinsulin and c-peptide has been reviewed with major emphasis on the most significant findings since 1972 . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
19,
29
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
34,
43
]
} |
the conversion of proinsulin which appears to occur exclusively in the pancreas leads to equimolar production of insulin and c-peptide . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
18,
28
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
125,
134
]
} |
although proinsulin has a direct biologic effect which is one-tenth as much as that of insulin , c-peptide has no biologic activity on homologous or heterologous tissue and no ability to modify the action of insulin and/or proinsulin . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
97,
106
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
223,
233
]
} |
although proinsulin has a direct biologic effect which is one-tenth as much as that of insulin , c-peptide has no biologic activity on homologous or heterologous tissue and no ability to modify the action of insulin and/or proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
12,
19
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
223,
233
]
} |
previous work on proinsulin immunoassay suggested that this prohormone , but not c-peptide , cross-reacts with insulin antiserum . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
17,
27
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
81,
90
]
} |
previous work on proinsulin immunoassay suggested that this prohormone , but not c-peptide , cross-reacts with insulin antiserum . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
17,
27
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
111,
118
]
} |
on the other hand , in the c-peptide immunoassay , proinsulin but not insulin cross-reacts with the antiserum . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
27,
36
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
51,
61
]
} |
on the other hand , in the c-peptide immunoassay , proinsulin but not insulin cross-reacts with the antiserum . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
51,
61
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
70,
77
]
} |
up to this time , therefore , it has not been possible to immunoassay human proinsulin or c-peptide specifically . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
76,
86
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
90,
99
]
} |
the very recent work from the laboratory of heding , however , has brought about major advances in this area in which human c-peptide and proinsulin can be separated in the plasma by the use of sepharose particles . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
124,
133
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
138,
148
]
} |
with the use of a specific enzyme which degrades insulin but not proinsulin , postprandial plasma proinsulin values have been measured in a large number of subjects under a variety of physiologic and pathologic conditions . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
49,
56
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
98,
108
]
} |
these results , which are comparable to those obtained by the more laborious column chromatography , could be summarized as follows : ( 1 ) proinsulin values in lean , young normal subjects do not vary greatly in response to insulin secretagogues ; | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
140,
150
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
225,
232
]
} |
the frequent absence of the classical features of malabsorption , diarrhoea with typical steatorrhoea and chronic debility was noted . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
50,
63
]
} | {
"id": "C0038238",
"name": "steatorrhoea",
"pos": [
89,
101
]
} |
drowning and near-drowning in the australian capital territory : a five-year total population study of immersion accidents . | NA | {
"id": "C0013142",
"name": "drowning",
"pos": [
0,
8
]
} | {
"id": "C0027516",
"name": "near-drowning",
"pos": [
13,
26
]
} |
six separate causes of bath drownings and near-drownings have been identified , and in 14 of the 19 accidents , two or more causes were operating concurrently . | NA | {
"id": "C0013142",
"name": "drownings",
"pos": [
28,
37
]
} | {
"id": "C0027516",
"name": "near-drownings",
"pos": [
42,
56
]
} |
there were 506 perinatal and infant deaths and 51 of the babies who died had malformations confirmed at necropsy . | NA | {
"id": "C0549159",
"name": "infant deaths",
"pos": [
29,
42
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
68,
72
]
} |
incidence of antibiotic-related diarrhoea and pseudomembranous colitis : a prospective study of lincomycin , clindamycin and ampicillin . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
96,
106
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
109,
120
]
} |
an existing intensive drug monitoring system was used to study the occurrence of pseudomembranous colitis and diarrhoea in 100 patients treated with lincomycin and clindamycin . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
149,
159
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
164,
175
]
} |
the incidences of diarrhoea in both groups were similar ( 11 % in the lincomycin-clindamycin group and 8 % in the ampicillin group ) . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
70,
80
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
81,
92
]
} |
this is shown particularly clearly in the classification of the patients operated on for pyogenic liver abscess in our hospital in the last ten years into multiple and solitary liver abscess . | NA | {
"id": "C0267830",
"name": "pyogenic liver abscess",
"pos": [
89,
111
]
} | {
"id": "C0023885",
"name": "liver abscess",
"pos": [
177,
190
]
} |
to assess the impact of an influenza a/port chalmers infection on normal young children , we monitored 147 children during an epidemic ; | NA | {
"id": "C0728836",
"name": "young",
"pos": [
73,
78
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
107,
115
]
} |
sjogren 's syndrome is associated with a serologically defined histocompatibility antigen of the hla-b locus , hla-b8 . | NA | {
"id": "C0019737",
"name": "hla-b locus",
"pos": [
97,
108
]
} | {
"id": "C0019746",
"name": "hla-b8",
"pos": [
111,
117
]
} |
to determine whether sjogren 's syndrome is primarily associated with an hla-d antigent or with hla-a and hla-b antigens as well as hla-dw3 , which is known to be in linkage disequilibrium with hla-b8 . | NA | {
"id": "C0019737",
"name": "hla-b antigens",
"pos": [
106,
120
]
} | {
"id": "C0019746",
"name": "hla-b8",
"pos": [
194,
200
]
} |
we found the primary association of association of sjogren 's syndrome to be with hla-dw3 , which we observed in 84 percent of patients with sjogren 's syndrome in the absence of rheumatoid arthritis as compared to 24 percent in controls ( p less than 0.00001 ) . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
51,
70
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
179,
199
]
} |
the frequency of hla-b8 and hla-dw3 in patients with both sjogren 's syndrome and rheumatoid arthritis did not differ from that in controls . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
58,
77
]
} | {
"id": "C0003873",
"name": "rheumatoid",
"pos": [
82,
92
]
} |
with a reversed isotope dilution technic with crystallization to constant specific activity , we showed the tumor tissue to convert dehydroepiandrosterone sulfate and dehydroepiandrosterone to estrone and estradiol . | NA | {
"id": "C0057277",
"name": "dehydroepiandrosterone sulfate",
"pos": [
132,
162
]
} | {
"id": "C0011185",
"name": "estrone",
"pos": [
193,
200
]
} |
by this method the immune complexes precipitated are taken up by antibodies conjugated to one enzyme and specific to the immunoglobulins of each class . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
19,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
65,
75
]
} |
precipitins to a. fumigatus were almost exclusively confined to specimens obtained from the compromised human group ( 51 % of those examined ) while candida precipitating antibodies were detected in the sera of both normal ( 26 % ) and compromised ( 49 % ) humans and in 10 % of the hedgehog specimens . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
0,
11
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
171,
181
]
} |
in relation to sunflower seed globulin isolate the content of lysine and the whole essential amino acids of the spun protein fibers is increased . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
30,
38
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
117,
124
]
} |
the enzymatic in-vitro-hydrolysis results altogether in a comparable availability of the amino acids between spun protein fibers and sunflower seed globulin isolates . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
114,
121
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
148,
156
]
} |
in the immediate posttransplant period , lmw protein and albumin excretion , expressed as a percentage of creatinine clearance , were high , revealing a mixed pattern , and excretion of both protein classes was higher than during both acute tubular necrosis and acute rejection crisis . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
57,
64
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
191,
198
]
} |
the only chance of finding asymptomatic aneurysm is brought about by paying special attention to aneurysm even in angiography for other intracranial diseases such as tumors , head injuries , vascular diseases and so on . | NA | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
40,
48
]
} | {
"id": "C0042373",
"name": "vascular diseases",
"pos": [
191,
208
]
} |
the results make it evident , that in the pathogenesis of epilepsy with focal sharp waves a genetically determined seizure susceptibility plays a very important role . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
58,
66
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
115,
122
]
} |
drug interactions during anticonvulsant therapy in childhood : diphenylhydantoin , primidone , phenobarbitone , clonazepam , nitrazepam , carbamazepin and dipropylacetate . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
83,
92
]
} | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
95,
109
]
} |
obese and nonobese subjects were similar in age and surgical indications , though overweight patients , who averaged nearly 60 % above standard weight for height and age , were more likely to have hypertension and diabetes mellitus . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
82,
92
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
144,
150
]
} |
the source of hemorrhage in a young woman who required emergency laparotomy for intraabdominal bleeding was found to be a very early primary pregnancy implanted on the undersurface of the right diaphragm , far behind the dome of the liver . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
14,
24
]
} | {
"id": "C0019065",
"name": "intraabdominal bleeding",
"pos": [
80,
103
]
} |
in such a way the immune complexes are treated by enzyme labeled antibodies specific to each class of immunoglobulin . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
18,
34
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
65,
75
]
} |
twenty-two hyperlipidemic and long-term alcoholic patients were chosen as subjects with a chronic alcohol-dependent hyperlipoproteinemia , since their lipidemia was getting normal after they stopped alochol ingestion . | NA | {
"id": "C0020476",
"name": "hyperlipoproteinemia",
"pos": [
116,
136
]
} | {
"id": "C0020473",
"name": "lipidemia",
"pos": [
151,
160
]
} |
initiation of the complement sequence via the alternative pathway by reaction with inulin was equal in patient and control sera when assessed by the activation of factor b , cleavage of c3 and the comsumption of hemolytic complement components ( table 1 ) . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
18,
28
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
163,
171
]
} |
the front-occipital circumference , frontooccipital and biparietal diameters , degree of suture overriding and weight were measured daily during the first week of life in 50 infants of birth weight under 2,000 gm . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
111,
117
]
} | {
"id": "C0005612",
"name": "infants",
"pos": [
174,
181
]
} |
the data obtained served as the basis for the search in the serum euglobulins of the patients with diabetes of compounds possibly possessing the antigenic properties , capable of producing antibodies and immune complexes , i.e . the immunological factors taking part in the vascular wall injury . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
189,
199
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
204,
220
]
} |
thermal denaturation profiles of duplexes formed between labeled bpv dna and dna from tumor cells indicated two tumors contained viral dna with base sequences identical to bpv dna . | NA | {
"id": "C0012930",
"name": "dna",
"pos": [
69,
72
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
176,
179
]
} |
three tumors ( including dna from the bpv-induced tumor ) contained bpv-related dna sequences that were less thermally stable . | NA | {
"id": "C0012930",
"name": "dna",
"pos": [
25,
28
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
80,
83
]
} |
seventeen hydrophilic proteins and five amphiphilic membrane proteins were subjected to agarose gel electrophoresis in the presence of a nonionic detergent ( triton x-100 ) , a mixture of anonionic and an anionic detergent ( triton x-100 and sodium deoxycholate ) , and a mixture of a nonionic and a cationic detergent ( triton x-100 and cetyltrimethylammonium bromide ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
22,
30
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
52,
69
]
} |
dna can be sequenced by a chemical procedure that breaks a terminally labeled dna molecule partially at each repetition of a base . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
126,
127
]
} |
this unexpected finding provided further confirmation of the identity of the chlorophylls on the basis of the fluorescence spectra at 77k of pheophytin a ( e 415 , f 669 ) and pheophytin b ( e 439 , f 655 ) . | NA | {
"id": "C0008260",
"name": "chlorophylls",
"pos": [
77,
89
]
} | {
"id": "C0031512",
"name": "pheophytin",
"pos": [
176,
186
]
} |
cells derived from other epithelial and other ectodermal tissues , fetal fibroblasts , cells of the blood buffy coat , and even fibroblasts of the breast itself do not bind the antibodies . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
128,
139
]
} |
during stimulation with hcg in vitro , such testes showed a transient decrease in cyclic amp response on the first day after gonadotropin treatment and no change in testosterone response . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
24,
27
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
125,
137
]
} |
cultured cloudman melanoma cells exposed either to dibutyryl 3':5'-cyclic amp and theophylline or to cholera toxin bind significantly more 125i-labeled beta-melanocyte stimulating hormone ( msh ) and fluorescein-labeled msh than untreated cells . | NA | {
"id": "C0005261",
"name": "beta-melanocyte stimulating hormone",
"pos": [
152,
187
]
} | {
"id": "C0026667",
"name": "msh",
"pos": [
220,
223
]
} |
both of these anions derepress atp sulfurylase in cells growing on sulfate , but not in cells growing on l-cysteine . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
14,
20
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
67,
74
]
} |
after such a treatment both types of vesicles exhibited the same total activity of ( na+ + k+ ) -stimulated mg2+ adenosinetriphosphatase ( atpase ; atp phosphohydrolase , ec 3.6.1.3 ) as in their native state . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
85,
87
]
} | {
"id": "C0001473",
"name": "atp",
"pos": [
148,
151
]
} |
tsny68-infected fibroblasts shifted to the non-permissive temperature acquired normal microtubular morphology more rapidly ( 2 hr ) than cells grown at the permissive temperature in the presence of protein synthesis inhibitors ( 7.5 hr ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
137,
142
]
} |
in a dna-dependent protein-synthesizing system that contains streptomycin-sensitive ribosomes , lambda dna directs the synthesis of two proteins that are products of the o gene . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
119,
128
]
} | {
"id": "C0033684",
"name": "products",
"pos": [
154,
162
]
} |
such increases in tyrosine hydroxylase activity are not observed in animals given ammonium chloride , another basic chloride-containing compound , by stomach tube or in animals treated with cycloheximide , an inhibitor of adrenal protein synthesis . | NA | {
"id": "C0002615",
"name": "ammonium chloride",
"pos": [
82,
99
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
116,
124
]
} |
studies on nucleic acid reassociation kinetics : rate of hybridization of excess rna with dna , compared to the rate of dna renaturation . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
11,
23
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
120,
123
]
} |
liposomes made from extracts of membrane lipid show qualitatively the same changes , indicating that the alteration of microviscosity results at least in part from changes in lipid composition . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
32,
46
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
175,
180
]
} |
a temperature-sensitive lethal mutant of escherichia coli has been constructed by combining two temperature-insensitive mutations : a rif180 mutation that modifies rna polymerase ( rna nucleotidyltransferase ; | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
164,
178
]
} | {
"id": "C0035673",
"name": "rna nucleotidyltransferase",
"pos": [
181,
207
]
} |
levels of erythrocyte delta-aminolevulinate dehydratase [ ala-dehydratase ; porphobilinogen synthase ; 5-aminolevulinate hydro-lyase ( adding 5-aminolevulinate and cyclizing ) , ec 4.2.1.24 ] , uroporphyrinogen-i synthase [ uro-synthase ; porphobilinogen ammonia-lyase ( polymerizing ) , ec 4.3 ; 1.8 ] , and protoporphyrin ix ( proto ) were measured by sensitive semimicroassays using 2-5 mul of whole blood obtained from normal and anemic mutant mice . | NA | {
"id": "C0020239",
"name": "dehydratase",
"pos": [
44,
55
]
} | {
"id": "C0002564",
"name": "5-aminolevulinate hydro-lyase",
"pos": [
103,
132
]
} |
mouse spleen cells cocultured with irradiated allogeneic stimulator cells develop cytolytic effector cells capable of lysing 51cr-labeled syngeneic trinitrophenyl-derivatized tumor or spleen targets and to a lesser degree unconjugated tumor cells in addition to the allogeneic stimulator cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
266,
276
]
} |
high-titer antiserum raised in rats against the tumor ( t ) antigen of polyoma virus was used to purify the t antigen by the staphylococcus protein a antibody adsorbent technique . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
11,
20
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
150,
158
]
} |
analysis of the correlations between size and chemical composition of lipoproteins of normolipidemic human plasma shows that the structure of all circulating lipoproteins is consistent with a spherical model of radius r in which a spherical liquid core of cholesterol esters and triglycerides of radius = r -- 20.2 a is surrounded by a monolayer of cholesterol and phospholipids with closely hydrophobic ends on the surface of the core . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
256,
274
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
349,
360
]
} |
free cholesterol is distributed among the circulating lipoproteins -- with the exception of very high density lipoprotein and perhaps chylomicrons -- according to a thermodynamic equilibrium governed by the curvature of the surface of the particle . | NA | {
"id": "C0023820",
"name": "circulating lipoproteins",
"pos": [
42,
66
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
134,
146
]
} |
when closed circular dna is used as a substrate , dna with one-site cleavages of one or both strands can be made by adding appropriate amounts of dye . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
12,
24
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
50,
53
]
} |
these nascent chains were nearly completely hydroxylated , as indicated by the presence of [ 3h ] hydroxyproline and high hydroxyproline/proline ratios . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
98,
112
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
137,
144
]
} |
these proteins were distinguished further by the chemical forms of [ 57co ] cbl found with them , hydroxocobalamin and methylcobalamin with the cytosolic protein and adenosylcobalamin with the mitochondrial one . | NA | {
"id": "C0042845",
"name": "cbl",
"pos": [
76,
79
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
98,
114
]
} |
these proteins were distinguished further by the chemical forms of [ 57co ] cbl found with them , hydroxocobalamin and methylcobalamin with the cytosolic protein and adenosylcobalamin with the mitochondrial one . | NA | {
"id": "C0042845",
"name": "cbl",
"pos": [
76,
79
]
} | {
"id": "C0065844",
"name": "cytosolic",
"pos": [
144,
153
]
} |
the nature of icb-cbl is unknown but appears important because icb- [ 57co ] cbl is missing from cultured fibroblasts of a group of patients whose cells take up cn- [ 57co ] cbl normally but do not convert it to either of its coenzyme forms . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
147,
152
]
} |
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