text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
amongst 1- ( substituted benzyl ) -4- ( substituted benzoyl ) piperazines exhibiting central nervous system ( 1 , 2 ) depressant activity it was found that 1- ( 2-chlorobenzyl ) -4- ( 2-chlorobenzoyl ) piperazine possessed maximum activity ( 2 ) . | NA | {
"id": "C0031958",
"name": "piperazines",
"pos": [
62,
73
]
} | {
"id": "C0031957",
"name": "possessed",
"pos": [
213,
222
]
} |
the ability of piperazine carbamides ( 3 ) and piperazinothiocarbamides to possess anticonvulsant activity ( 4 ) prompted synthesis of 1- ( 1-aryl-3-ethylthiocarbamido ) -4- ( arylaminothiocarbonyl ) piperazines and evaluation of their anticonvulsant activity . | NA | {
"id": "C0031957",
"name": "carbamides",
"pos": [
26,
36
]
} | {
"id": "C0031958",
"name": "piperazines",
"pos": [
200,
211
]
} |
there was a significant decrease in sphincteric activity following both epinephrine and norepinephrine administration in both cats and dogs , using both constant pressure and constant flow methods . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
88,
102
]
} |
from our observations , and from a critical review of the literature , we conclude that the characteristic craniofacial malformations of apert 's syndrome are not caused by premature fusion of the cranial sutures , as has been commonly postulated . | NA | {
"id": "C0376634",
"name": "craniofacial malformations",
"pos": [
107,
133
]
} | {
"id": "C0010278",
"name": "premature",
"pos": [
173,
182
]
} |
in a study of 16 psychotic patients with neuroleptic-induced tardive dyskinesia and 16 patients with parkinson 's disease and l-dopa-induced hyperkinesia it was found that ( 1 ) tardive dyskinesia , compared to l-dopa hyperkinesia , was localized almost exclusively to the oral region ( p mean value of 0.01 ) , whereas thel-dopa hyperkinesia was more pronounced in the neck ( p mean value of 0.05 ) and the extremities ( p mean value of 0.05 ) ; | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
126,
132
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
325,
329
]
} |
adrenaline and noradrenaline excretion decreased , skin temperature increased , and hand steadiness was improved when the subjects stopped smoking . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
a strong relationship was found to exist between the heart rate in any one minute and the number of premature ventricular contractions , with higher rates associated with a greater number of these ectopic beats . | NA | {
"id": "C0151636",
"name": "premature ventricular contractions",
"pos": [
100,
134
]
} | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
197,
210
]
} |
use of the lateral view in selective renal angiography is helpful in differentiating cysts from tumors . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
85,
90
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
96,
102
]
} |
that neurons important to the control of body temperature are selectively sensitive to pge2 and not to analogs of prostaglandin precursors suggests that local cyclic endoperoxides can influence body temperature only through bioconversion to prostaglandin . | NA | {
"id": "C0033568",
"name": "analogs",
"pos": [
103,
110
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
241,
254
]
} |
human synovial fibroblasts in culture respond to bradykinin with a 20-fold increment in intracellular cyclic amp concentrations , however bradykinin does not directly activate adenylate cyclase activity in a particulate fraction derived from these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
248,
253
]
} |
prostaglandins e and f in uterine venous plasma and progesterone ( p ) and 20alpha-hydroxyprogesterone ( 20alpha-oh-p ) in peripheral plasma were measured by radioimmunoassays throughout pregnancy and parturition in the rat . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
52,
64
]
} | {
"id": "C0020387",
"name": "hydroxyprogesterone",
"pos": [
83,
102
]
} |
f prostaglandin levels are always higher than e prostaglandins and show distinct peaks around day 5 ( 5 ng/ml ) , day 11 ( 7 ng/ml ) , and before parturition ( 8.4 ng/ml ) . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
2,
15
]
} | {
"id": "C0033559",
"name": "e",
"pos": [
144,
145
]
} |
methadone and its metabolites were found to be present in urine , liver and serum of rats treated with alpha-l-acetylmethadol . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
0,
9
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
111,
125
]
} |
the purpose of this study was to determine whether alpha-l-acetylmethadol is metabolized to methadone , which might explain in part the longer duration of action of alpha-l-acetylmethadol . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
92,
101
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
173,
187
]
} |
a theoretical analysis of the distribution of thyroxine among sites on thyroid binding globulin , thyroid binding prealbumin , and serum albumin . | NA | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
114,
124
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
131,
144
]
} |
clinical investigation and e.e.g . carried out on these 11 children showed that they were suffering from either hemiphegia or hemiparesis ( 8 out of 11 cases ) and hemianopsia ( 7 out of 11 cases ) , and had serious epilepsy with partial fits ( 6 cases ) , usual temporal lobe epilepsy ( 5 cases ) , generalized secondary epilepsy ( 3 cases ) or epilepsy defying classification ( 2 cases ) . | NA | {
"id": "C0014547",
"name": "epilepsy",
"pos": [
216,
224
]
} | {
"id": "C0014556",
"name": "temporal lobe epilepsy",
"pos": [
263,
285
]
} |
clinical investigation and e.e.g . carried out on these 11 children showed that they were suffering from either hemiphegia or hemiparesis ( 8 out of 11 cases ) and hemianopsia ( 7 out of 11 cases ) , and had serious epilepsy with partial fits ( 6 cases ) , usual temporal lobe epilepsy ( 5 cases ) , generalized secondary epilepsy ( 3 cases ) or epilepsy defying classification ( 2 cases ) . | NA | {
"id": "C0036572",
"name": "fits",
"pos": [
238,
242
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
346,
354
]
} |
[ the biochemistry of collagen and the locomotor apparatus . hereditary diseases of connective tissue and rheumatologic diseases ( part 2 ) ] . | NA | {
"id": "C0009782",
"name": "the",
"pos": [
2,
5
]
} | {
"id": "C0009326",
"name": "rheumatologic diseases",
"pos": [
106,
128
]
} |
the indirect immunofluorescence method after exposure to animal dna ( if ) and farr 's radio-immunological method with bacterial dna labelled with c14 , gave highly similar results , although there were some cases in which farr 's method gave a negative and the if method a positive result . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
64,
67
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
119,
132
]
} |
[ biochemistry of collagen and locomotor apparatus . hereditary diseases of the connective tissue and rheumatic diseases ( 3 ) ] . | NA | {
"id": "C0009782",
"name": "diseases of the",
"pos": [
64,
79
]
} | {
"id": "C0035435",
"name": "rheumatic diseases",
"pos": [
102,
120
]
} |
0.5 ie insulin/kg bodyweight intravenously was followed by an immediate gastric relaxation , obvious before any marked decrease of blood glucose or plasma potassium occurred , and furthermore not affected by administration of glucose or potassium . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
131,
144
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
226,
233
]
} |
all homozygous hps patients have the typical triad of oculocutaneous albinism , pigmented macrophages in the bone marrow and a bleeding disorder , based on a platelet dysfunction . | NA | {
"id": "C0079504",
"name": "hps",
"pos": [
15,
18
]
} | {
"id": "C0078918",
"name": "oculocutaneous albinism",
"pos": [
54,
77
]
} |
the effect of pmsf was dose- , time- , and temperature-dependent , and hydrolytic products of pmsf as well as sodium fluoride were inactive in blocking lif . | NA | {
"id": "C0016327",
"name": "products",
"pos": [
82,
90
]
} | {
"id": "C0037508",
"name": "sodium",
"pos": [
110,
116
]
} |
with antisera specific for each of the three vh subgroups , vhi , vhii , and vhiii , a clear vh subgroup restriction was shown in these antibody preparations . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
5,
13
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
136,
144
]
} |
with antisera specific for each of the three vh subgroups , vhi , vhii , and vhiii , a clear vh subgroup restriction was shown in these antibody preparations . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
5,
13
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
136,
144
]
} |
because the platelet aggregation test is being used for screening of circulating immune complexes , falsely positive reactions caused by hla antibodies must be eliminated by adequate control experiments . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
69,
97
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
141,
151
]
} |
the findings were not due to irrelevant antibodies in the anti-theta antiserum , and neonatally thymectomized mice grafted with a thymic lobe showed percentages of theta-positive cells in the bone marrow comparable to those of sham-operated animals . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
40,
50
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
69,
78
]
} |
it is concluded that extensive surgery for stone removal with the use of external parenchymatous cooling is worthwhile and promising in patients with staghorn calculi or multiple stones in the kidneys . | NA | {
"id": "C0333014",
"name": "staghorn calculi",
"pos": [
150,
166
]
} | {
"id": "C0022650",
"name": "stones in",
"pos": [
179,
188
]
} |
the activities of 5'-nucleotidase , k+ , na+-activated mg2+-dependent adenosine triphosphatase ( atpase ) and leucine-beta-naphthylamidase were determined from 17 rheumatoid synovial fluids and from extracts of the corresponding synovial tissues . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
55,
58
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
97,
103
]
} |
fifty-five of ther 1223 women aged 40-64 years had bacteriuria and 31 were under treatment for urinary tract infection . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
51,
62
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
95,
118
]
} |
vaccination of adults with a dite vaccine containing a reduced amount of di-toxoid is recommanded . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
34,
41
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
76,
82
]
} |
l-carbidopa/l-dopa affords a real alternative therapy in the modern treatment of parkinson 's disease with l-dopa and a decarboxylase inhibitor . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
7,
11
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
107,
113
]
} |
recombinant phages have been constructed in vitro by joining the smaller fragment of ribosomal dna and the outer arms of dna from the vector lambdagtwes-lambdac . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
85,
98
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} |
the initial analysis of the inserted transfer rna genes via the colony hybridization technique with individual radioactive transfer rna species is reported . | NA | {
"id": "C0035711",
"name": "transfer",
"pos": [
37,
45
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
132,
135
]
} |
we have synthesized an analog ( ara-cdp-dl-dipalmitin ) of cytidine diphosphate diglyceride ( cdp-diglyceride ) in which the antitumor drug , cytosine arabinoside , is substituted for the cytidine moiety . | NA | {
"id": "C0010724",
"name": "cytidine diphosphate",
"pos": [
59,
79
]
} | {
"id": "C0010726",
"name": "cdp-diglyceride",
"pos": [
94,
109
]
} |
of 115 such patients , 65 % had sickle cell disease and 35 % had sickle cell trait . | NA | {
"id": "C0002895",
"name": "sickle cell disease",
"pos": [
32,
51
]
} | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
65,
82
]
} |
the tumor series included 13 leiomyomas , four cysts , two cases of multiple polyps , and one case of granular cell myoblastoma . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
4,
9
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
47,
52
]
} |
there was no relation between bacteriuria and age , duration of diabetes , treatment for diabetes , quality of control of diabetes , symptoms of urinary tract infection or hypertension . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
30,
41
]
} | {
"id": "C0042029",
"name": "of urinary tract infection",
"pos": [
142,
168
]
} |
in vivo the simultaneous use of cerium sulfadiazine and silver sulfadiazine was more effective than silver sulfadiazine alone or the combination of cerous nitrate and silver sulfadiazine . | NA | {
"id": "C0038675",
"name": "sulfadiazine",
"pos": [
39,
51
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
167,
186
]
} |
free silver and sulfadiazine ions are available also in small amounts because of limited ionization of the highly insoluble silver sulfadiazine . | NA | {
"id": "C0038675",
"name": "sulfadiazine",
"pos": [
16,
28
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
124,
143
]
} |
the choleretic effect was associated with a high increase in sodium , chloride and bicarbonate anions and with a smaller increase in potassium , phosphorus and calcium . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
70,
78
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
95,
101
]
} |
in patients with cirrhosis , the initial operative mortality rate ( three of 12 patients ) and the subsequent mortality rate ( five additional patients ) reflect the greater risk because of liver disease . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
17,
26
]
} | {
"id": "C0023895",
"name": "the",
"pos": [
162,
165
]
} |
in patients with cirrhosis , the initial operative mortality rate ( three of 12 patients ) and the subsequent mortality rate ( five additional patients ) reflect the greater risk because of liver disease . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
17,
26
]
} | {
"id": "C0023895",
"name": "the",
"pos": [
162,
165
]
} |
as the minimum inhibitory concentration of cefazolin for organisms commonly found in the bile is 0.5 to 6 mug per milliliter , we suggest that cefazolin sodium may be of value in the treatment of biliary disease , particularly acute cholecystitis . | NA | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
43,
52
]
} | {
"id": "C0700526",
"name": "cefazolin sodium",
"pos": [
143,
159
]
} |
one tumor was intimately associated with the kidney and consisted of isolated ductular and tubular structures within an abundant connective tissue stroma and was diagnosed as a hamartoma of urogenital origin . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
4,
9
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
177,
186
]
} |
the activity of microsomal drug-metabolizing enzymes is altered by several pathological or abnormal physiological states , such as changes in nutritional status , liver , heart or kidney diseases , hormonal disturbances , pregnancy , tumour-bearing state , adjuvant arthritis , changes in reticuloendothelial system and environmental factors ( stress , irradiation , heavy metals ) . | NA | {
"id": "C2916830",
"name": "physiological states",
"pos": [
100,
120
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
222,
231
]
} |
associated were subarchnoid hemorrhages over the upper vermis and thin layered hematomas between the tentorium and the cerebellum . | NA | {
"id": "C0019080",
"name": "hemorrhages",
"pos": [
28,
39
]
} | {
"id": "C0018944",
"name": "hematomas",
"pos": [
79,
88
]
} |
the panniculitis which is part of the symptoms corresponds to the weber-christian disease or erythema nodosum . | NA | {
"id": "C0030326",
"name": "panniculitis",
"pos": [
4,
16
]
} | {
"id": "C0030328",
"name": "weber-christian disease",
"pos": [
66,
89
]
} |
the neoplastic growth was classified as a malignant histiocytoma , and the hyperglycemia was taken as a paraneoplastic syndrome ( doege-potter ) . | NA | {
"id": "C0027651",
"name": "neoplastic growth",
"pos": [
4,
21
]
} | {
"id": "C0030472",
"name": "paraneoplastic syndrome",
"pos": [
104,
127
]
} |
the results were compared with findings of other authors obtained after combined application of chemical carcinogens and corticosteroid hormones . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
121,
135
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
136,
144
]
} |
the adenocarcinoma is the only alternative in differential diagnosis to the alveolar cell carcinoma in view of the cytological and histological criteria . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
4,
18
]
} | {
"id": "C0007120",
"name": "alveolar cell carcinoma",
"pos": [
76,
99
]
} |
the in vitro susceptibility to thiamphenicol and chloramphenicol of 272 anaerobes , most of which were recent clinical isolated , was determined by broth dilution tests , with chloramphenicol , 133 anaerobic gram-negative non-sporing rods ( 48 bacteroides fragilis , 13 b. thetaiotaomicron , 14 b. oralis , 16 sphaerophorus varius etc . ) had mic values of 0.03 through 16 microng/ml . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
31,
44
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
176,
191
]
} |
in concentrations of 4 microng/ml or less chloramphenicol inhibited 90.2 % and thiamphenicol 78.95 % of the strains . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
42,
57
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
79,
92
]
} |
members of the fusobacterium and sphaerophorus group were susceptible to less than or equal to 2 microng chloramphenicol/ml and less than or equal to 4 microng thiamphenicol/ml respectively . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
105,
120
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
160,
173
]
} |
of 37 clostridium isolates , 35 ( belonging to c. perfringens , c. septicum , c. cadaveris etc . ) were inhibited by concentrations of 8 microng/ml or less of chloramphenicol and thiamphenicol . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
159,
174
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
179,
192
]
} |
therefore , inhibition zone diameter measurement can not be regarded as a reliable method to detect chloramphenicol or thiamphenicol resistance in anaerobes . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
100,
115
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
119,
132
]
} |
thiamphenicol , which is virtually as active against anaerobes as chloramphenicol but lacks serious toxicity , may well play an important role in the therapy of various anaerobic infections . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
0,
13
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
66,
81
]
} |
these cycles were normal according to a number of criteria , including daily plasma levels of oestradiol , 17-hydroxyprogesterone and progesterone . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
107,
129
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
134,
146
]
} |
the use of the 1st irp of human pituitary gonadotrophins ( fsh and lh ( icsh ) ) for bioassay ( herafter hpg-1st irp ) as standard in this system resulted invariably in invalid assays , due to lack of parallelism . | NA | {
"id": "C0018066",
"name": "pituitary gonadotrophins",
"pos": [
32,
56
]
} | {
"id": "C0023607",
"name": "lh",
"pos": [
67,
69
]
} |
comparison of effects of c19 ( androstene or androstane ) steroids on serum gonadotrophin concentrations and on accessory reproductive organ weights in gonadectomized , adult male rats . | NA | {
"id": "C0002854",
"name": "androstane",
"pos": [
45,
55
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
58,
66
]
} |
the effects of subcutaneous administration of graded doses of c19 ( androstene or androstane ) steroids on serum levels of lh and fsh and on weights of accessory reproductive organs in gonadectomized , adult male rats were investigated . | NA | {
"id": "C0002854",
"name": "androstane",
"pos": [
82,
92
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
95,
103
]
} |
with the amounts of steroids used , 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha , 17beta-diol had a high potency in preventing the rise of serum gonadotrophin concentrations and in curbing the decrease weights of ventral prostates and seminal vesicles following orchidectomy . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
20,
28
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
74,
84
]
} |
in both pregnancy and trophoblastic disease ( hydatidiform mole and choriocarcinoma but not metastatic choriocarcinoma ) tebg levels were elevated ( 17.5 +/- 0.70 and 14.9 +/- 1.49 , respectively ) . | NA | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
22,
43
]
} | {
"id": "C0020217",
"name": "hydatidiform mole",
"pos": [
46,
63
]
} |
cartilage reconstructed by chondrocytes from the younger group of animals displayed regular arrangement of cells , i.e . smaller cells at the periphery and larger in the centre . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
27,
39
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
transplantation of chondrocytes from 28 or 56-day-old rabbits ( older group ) led to the reconstruction of cartilage with irregular distribution of cells , i.e . some large cells were located at its periphery , while in the centre smaller and larger cells were intermingled in a haphazard manner . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
19,
31
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
250,
255
]
} |
three benzodiazepines in equipotent doses : oxazepam 15 mg , dipotassium chlorazepate 10 mg and diazepam 5 mg , were administered in single , oral doses to seven healthy volunteers in a three-way cross-over study . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
6,
21
]
} | {
"id": "C0009033",
"name": "dipotassium",
"pos": [
61,
72
]
} |
the serum concentrations of oxazepam , n-desmethyldiazepam and diazepam were followed for 72 hours by gas chromatography and electron capture detection . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
41,
58
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
63,
71
]
} |
the absorption of diazepam was most rapid and the mean time required to reach peak serum concentration was 45 minutes , followed by n-desmethyldiazepam 80 minutes and oxazepam 114 minutes . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
18,
26
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
134,
151
]
} |
the serum concentration decay curves were biphasic with terminal mean half-lives of 48 , 62 and 11 hours for diazepam , n-desmethyldiazepam and oxazepam , respectively . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
109,
117
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
122,
139
]
} |
the relatively high level of na in the ihd group is assumed to be a contributory factor in the intracellular metabolic as well as in the systemic changes typical of ischaemia and infarction . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
165,
174
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
179,
189
]
} |
[ the analysis of cerebrospinal fluid glycoprotein on the central nervous diseases . 2 ) the pas positive substance in csf and serum existing among albumin and prealbumin on disc electrophoresis ( author 's transl ) ] . | NA | {
"id": "C0036773",
"name": "serum",
"pos": [
127,
132
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
160,
170
]
} |
in young children with a mean age of 21 months , the relative pancreatic and salivary amylase isozyme activities of urine were significantly changed in marginally malnourished children compared to normal children . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
3,
17
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
204,
212
]
} |
a slowly progressive neurological disorder occurred simultaneously , consisting of progressive external ophthalmoplegia , mitochondrial myopathy , ataxia , neural deafness , mental subnormality , atypical retinitis , corneal dystrophy , cataract , and increased protein level in the cerebrospinal fluid . | NA | {
"id": "C0162674",
"name": "progressive",
"pos": [
9,
20
]
} | {
"id": "C0162670",
"name": "mitochondrial myopathy",
"pos": [
122,
144
]
} |
long-term follow-up studies on herpes simplex antibodies in the course of cervical cancer : patterns of neutralizing antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
46,
56
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
104,
127
]
} |
in an attempt to find differences between the tumor cells and equivalent embryonic cells , we have studied the electron microscopic cytochemical localization of alkaline phosphatase , 5'-nucleotidase , and mg2+-activated adenosine triphosphatase ( atpase ) in embryo-derived teratocarcinomas and mouse egg-cylinders . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
206,
209
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
248,
254
]
} |
choroid plexus of rabbit and rat was incubated for 2-30 min at 37 degrees c under 95 % o2-5 % co2 in tyrode solution containing 10 mm glucose and 1 mm theophylline with these agents : epinephrine , norepinephrine , isoproterenol , dopamine , histamine , serotonin , arginine , and lysine vasopressins , oxytocin , angiotensin , adrenocorticotropin ( acth ) , beta-melanocyte-stimulating hormone , and choroid plexus peptide iif . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
184,
195
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
198,
212
]
} |
med 's for this effect by isoproterenol , epinephrine , and norepinephrine were .001 , .01 , and 10 microng/ml ( 4.7 x 10 ( -9 ) , 5.5 x 10 ( -8 ) , and 5.9 x 10 ( -5 ) m ) , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
lung mitochondrial preparations formed significant levels of acetylcarnitine in the presence of pyruvate and carnitine . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
61,
76
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
109,
118
]
} |
the rank order of effectiveness of androgens in vitro was dihydrotestosterone , testosterone , methyltestosterone , androstendione , and androsterone , which correlates with their androgenicity . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
65,
77
]
} | {
"id": "C0025826",
"name": "methyltestosterone",
"pos": [
95,
113
]
} |
the evaluation of multiple cause of death as mentioned on death certificates can allow for assessment of significant co-factors contributing to a fatal outcome in a disease like cirrhosis of the liver . | NA | {
"id": "C0023895",
"name": "disease",
"pos": [
165,
172
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
178,
187
]
} |
in nine jaundiced patients the concentrations of cytochrome a ( +a3 ) , as representative of respiratory enzymes , increased to more than 1.0 x 10 ( -10 ) moles/mg protein , as compared with 0.81 of normal mitochondria , and the relative concentrations of cytochromes , flavoproteins and pyridine nucleotides in relation to cytochrome a ( +a3 ) level remained unchanged . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
164,
171
]
} | {
"id": "C0016223",
"name": "flavoproteins",
"pos": [
270,
283
]
} |
( 5 ) the extent of the cellular reaction , the enumeration of giant , inflammatory , and fibroblastic cells showed the superiority of mesh materials ; | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
24,
32
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
90,
108
]
} |
postoperative hemorrhage is an ominous complication and is best treated conservatively until blood loss can not be replaced . | NA | {
"id": "C0032788",
"name": "postoperative hemorrhage",
"pos": [
0,
24
]
} | {
"id": "C0019080",
"name": "blood loss",
"pos": [
93,
103
]
} |
in hot weather , when the subjects were sweating , a rise in serum electrolytes occurred , indicating fluid deficit of about 1-8 litres after a mean period of starvation of 11 hours ; | NA | {
"id": "C0162429",
"name": "deficit",
"pos": [
108,
115
]
} | {
"id": "C0038187",
"name": "starvation",
"pos": [
159,
169
]
} |
although alterations in spermatogenesis may be most important in the antifertility effect of progestin and androgen , these alterations in epididymal sperm and epithelium may also play a role . | NA | {
"id": "C1372885",
"name": "alterations",
"pos": [
9,
20
]
} | {
"id": "C1372883",
"name": "alterations",
"pos": [
124,
135
]
} |
the results indicate that the three lipid-soluble anesthetics interact differently with the lipid part of membranes . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
36,
41
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
92,
97
]
} |
nasal provocation tests with allergen ( house dust 5.0 mg/ml or grass-pollen 10000 noon units/ml ) were performed on patients suffering from perennial rhinitis or pollinosis . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
29,
37
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
40,
50
]
} |
the in vitro susceptibility of escherichia coli , salmonella sp , pasteurella multocida , and pseudomonas aeruginosa strains isolated from young calves and their environment to kanamycin and its semisynthetic derivative -- amikacin , was compared by the tube dilution method . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
177,
186
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
223,
231
]
} |
the minimal inhibitory concentration of amikacin was two- to fourfold lower than the minimal inhibitory concentration of kanamycin for the salmonella group b , ps aeruginosa and p multocida strains examined , whereas the e coli and salmonella group d strains were eqaully susceptible to the 2 antibiotics . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
40,
48
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
121,
130
]
} |
the concentrations of amikacin and kanamycin in the serum of calves after single intramuscular injections at 10 , 25 , and 50 mg/kg were determined , and differences between the 2 antibiotics were not observed . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
22,
30
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
35,
44
]
} |
six protein fractions were clearly and consistently resolved : albumin and alpha1- , alpha2- , beta1- , beta2- , and gamma-globulins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
63,
70
]
} |
the vee geometric mean antibody titers ( gmt ) increased 26- and 64-fold for hi antibodies and for neutralizing antibodies , respectively , in 5 animals that had prechallenge exposure titers of vee neutralizing antibodies only . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
80,
90
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
198,
221
]
} |
in contrast , the gmt increased only threefold and eightfold for vee hi antibodies and for neutralizing antibodies , respectively , in 8 animals that had prechallenge exposure titers of both vee hi and neutralizing antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
72,
82
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
202,
225
]
} |
five patients who had injected intravenous ( i.v . ) phenmetrazine or methamphetamine developed marked prostration resembling septic shock , disseminated intravascular coagulation , rhabdomyolysis with myoglobinuria , and azotemia . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
182,
196
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
202,
215
]
} |
severe pulmonary hypertension without pulmonary fibrosis occurred in 10 patients with the crest syndrome ( calcinosis , raynaud 's phenomenon , esophageal dysfunction , sclerodactyly , telangiectasia ) , reputedly a benign variant of progressive systemic sclerosis . | NA | {
"id": "C0206138",
"name": "crest syndrome",
"pos": [
90,
104
]
} | {
"id": "C0006663",
"name": "calcinosis",
"pos": [
107,
117
]
} |
because of the focal nature of the hemorrhage , the hematuria may not have been perceived as part of a general hemorrhagic disorder and the diagnosis not pursued . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
35,
45
]
} | {
"id": "C0018965",
"name": "hematuria",
"pos": [
52,
61
]
} |
the overall results obtained by the procedure appear to be useful as an aid in the diagnosis of type i glycogenosis , a glycogen storage disease called von gierke 's disease . | NA | {
"id": "C0017919",
"name": "glycogen storage disease",
"pos": [
120,
144
]
} | {
"id": "C0017920",
"name": "von gierke 's disease",
"pos": [
152,
173
]
} |
the congenitally athymic nude mice sensitive to anti-0-serum plus complement , resistent to treatment with corticosteroid hormones and dependent of the presence of the thymus in adult life . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
107,
121
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
122,
130
]
} |
the successful passive transfer of the disease by local injections of immune serum and the demonstration by immunofluorescence of immune complexes in the ocular tissues are arguments for the role of humoral antibodies in the induction of the disease . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
130,
146
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
207,
217
]
} |
this new optic opens the way to the use of different immunotherapy regimens including transfer factor or whole lymphokines , and stimulation of the immune response with immunological adjuvants rather than immunosuppressive agents used during recent years ( like steroids , acth ) which have an antiinflammatory as well as an immunosuppressive function . | NA | {
"id": "C0040673",
"name": "transfer factor",
"pos": [
86,
101
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
111,
122
]
} |
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