text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
both parasitic materials decreased tritiated thymidine and leucine uptake in normal spleen cells from cba mouse and fischer rats and in peripheral human blood lymphocytes stimulated either by non specific mitogens ( pha , cona , or lps ) or by allogeneic cells . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
77,
83
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
244,
254
]
} |
in contrast to the responsiveness of a congeneic high responder subline , lps is unable to stimulate thymidine incorporation by splenocytes of the low-responder subline and to protect these mice against an unrelated bacterial infection , moreover , although endotoxin extracted by trichloroacetic acid was mitogenic in these low-responder mice , it was still unable to increase their resistance against an infectious challenge ; | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
74,
77
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
258,
267
]
} |
inheritance of susceptibility to lethal effect of endotoxin and of lps-induced non-specific resistance to infection was also tested in both sublines , their hybrids and backcross progeny . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
50,
59
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
67,
70
]
} |
ampicillin proved to be 2 times more resistant to the effect of serum acylase as compared to benzylpenicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
0,
10
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
93,
109
]
} |
this inhibition is completely prevented by uracil , deoxyuridine , and 5-bromouracil , partly prevented ( 40 to 90 % of growth observed without 5-fluorouracil ) by uridine , thymidine , and 5-bromodeoxyuridine , and slightly prevented by trifluorothymine , cytosine , cytidine , deoxycytidine , and 5-methylcytosine ( all at 0.5 to 1 mm ) . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
43,
49
]
} | {
"id": "C0006242",
"name": "5-bromouracil",
"pos": [
71,
84
]
} |
this inhibition is completely prevented by uracil , deoxyuridine , and 5-bromouracil , partly prevented ( 40 to 90 % of growth observed without 5-fluorouracil ) by uridine , thymidine , and 5-bromodeoxyuridine , and slightly prevented by trifluorothymine , cytosine , cytidine , deoxycytidine , and 5-methylcytosine ( all at 0.5 to 1 mm ) . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
43,
49
]
} | {
"id": "C0016360",
"name": "fluorouracil",
"pos": [
146,
158
]
} |
this inhibition is completely prevented by uracil , deoxyuridine , and 5-bromouracil , partly prevented ( 40 to 90 % of growth observed without 5-fluorouracil ) by uridine , thymidine , and 5-bromodeoxyuridine , and slightly prevented by trifluorothymine , cytosine , cytidine , deoxycytidine , and 5-methylcytosine ( all at 0.5 to 1 mm ) . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
52,
64
]
} | {
"id": "C0006233",
"name": "5-bromodeoxyuridine",
"pos": [
190,
209
]
} |
this inhibition is completely prevented by uracil , deoxyuridine , and 5-bromouracil , partly prevented ( 40 to 90 % of growth observed without 5-fluorouracil ) by uridine , thymidine , and 5-bromodeoxyuridine , and slightly prevented by trifluorothymine , cytosine , cytidine , deoxycytidine , and 5-methylcytosine ( all at 0.5 to 1 mm ) . | NA | {
"id": "C0010843",
"name": "cytosine",
"pos": [
257,
265
]
} | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
299,
315
]
} |
this inhibition is completely prevented by uracil , deoxyuridine , and 5-bromouracil , partly prevented ( 40 to 90 % of growth observed without 5-fluorouracil ) by uridine , thymidine , and 5-bromodeoxyuridine , and slightly prevented by trifluorothymine , cytosine , cytidine , deoxycytidine , and 5-methylcytosine ( all at 0.5 to 1 mm ) . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
268,
276
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
279,
292
]
} |
growth is also inhibited by 0.2 mm 6-azauracil , and this inhibition was completely prevented by uracil and uridine , partly prevented by deoxyuridine , 5-bromouracil , cytidine , and 5-methylcytosine , and slightly prevented by thymine , thymidine , 5-bromodeoxyuridine , cytosine , and deoxycytidine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
40,
46
]
} | {
"id": "C0006242",
"name": "5-bromouracil",
"pos": [
153,
166
]
} |
growth is also inhibited by 0.2 mm 6-azauracil , and this inhibition was completely prevented by uracil and uridine , partly prevented by deoxyuridine , 5-bromouracil , cytidine , and 5-methylcytosine , and slightly prevented by thymine , thymidine , 5-bromodeoxyuridine , cytosine , and deoxycytidine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
40,
46
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
229,
236
]
} |
growth is also inhibited by 0.2 mm 6-azauracil , and this inhibition was completely prevented by uracil and uridine , partly prevented by deoxyuridine , 5-bromouracil , cytidine , and 5-methylcytosine , and slightly prevented by thymine , thymidine , 5-bromodeoxyuridine , cytosine , and deoxycytidine . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
138,
150
]
} | {
"id": "C0006233",
"name": "5-bromodeoxyuridine",
"pos": [
251,
270
]
} |
growth is also inhibited by 0.2 mm 6-azauracil , and this inhibition was completely prevented by uracil and uridine , partly prevented by deoxyuridine , 5-bromouracil , cytidine , and 5-methylcytosine , and slightly prevented by thymine , thymidine , 5-bromodeoxyuridine , cytosine , and deoxycytidine . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
169,
177
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
288,
301
]
} |
growth is also inhibited by 0.2 mm 6-azauracil , and this inhibition was completely prevented by uracil and uridine , partly prevented by deoxyuridine , 5-bromouracil , cytidine , and 5-methylcytosine , and slightly prevented by thymine , thymidine , 5-bromodeoxyuridine , cytosine , and deoxycytidine . | NA | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
184,
200
]
} | {
"id": "C0010843",
"name": "cytosine",
"pos": [
273,
281
]
} |
in vitro activity of ticarcillin against anaerobic bacteria compared with that of carbenicillin and penicillin . | NA | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
21,
32
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
100,
110
]
} |
a total of 334 clinical anaerobic isolates were tested in an anaerobic glove box by the agar dilution technique for susceptibility to clinically achievable levels of ticarcillin , carbenicillin , and penicillin . | NA | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
166,
177
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
200,
210
]
} |
within the therapeutic range , ticarcillin was the most effective of the three penicillins tested against b. fragilis subsp . fragilis . | NA | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
31,
42
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
79,
90
]
} |
antibiotics available at the time of testing included ampicillin , penicillin , methicillin , erythromycin , clindamycin , tetracycline , and minocycline . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
67,
77
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
80,
91
]
} |
the inhibitory activity of this compound was similar to that of cephalexin and cephradine when tested against 602 clinical isolates on mueller-hinton medium . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
64,
74
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
79,
89
]
} |
in the oral treatment of experimental infections of mice , cefadroxil was more effective than cephalexin against streptococcus pyogenes , and comparably effective against streptococcus pneumoniae , staphylococcus aureus , and several gram-negative species . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
59,
69
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
94,
104
]
} |
administered orally to mice , at doses ranging from 25 to 100 mg/kg , cefadroxil attained peak concentrations in the blood similar to those of cephalexin . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
70,
80
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
143,
153
]
} |
at a dose of 200 mg/kg , however , higher peak levels were noted with cefadroxil than with cephalexin . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
70,
80
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
91,
101
]
} |
in regard to other properties which were investigated , the behavior of cefadroxil compared favorably to that of cephalexin . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
72,
82
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
113,
123
]
} |
at equivalent oral doses , cefadroxil has a longer serum half-life , slower urinary excretion rate , greater area under the serum level versus time curve than cephalexin or cephradine , and peak serum concentrations that are 75 to 80 % those of cephalexin . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
27,
37
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
245,
255
]
} |
at equivalent oral doses , cefadroxil has a longer serum half-life , slower urinary excretion rate , greater area under the serum level versus time curve than cephalexin or cephradine , and peak serum concentrations that are 75 to 80 % those of cephalexin . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
173,
183
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
245,
255
]
} |
the calculated , apparent in vivo volume of distribution of cefadroxil is greater than that of cephalexin . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
60,
70
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
95,
105
]
} |
these properties infer greater persistence of cefadroxil in serum and urine and more prolonged in vivo bacterial exposure to cefadroxil than to cephalexin or cephradine . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
46,
56
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
144,
154
]
} |
these properties infer greater persistence of cefadroxil in serum and urine and more prolonged in vivo bacterial exposure to cefadroxil than to cephalexin or cephradine . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
144,
154
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
158,
168
]
} |
the activity of netilmicin against a variety of bacteria was similar to that of gentamicin , sisomicin , and tobramycin , but it was less active than these three drugs against pseudomonas aeruginosa . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
16,
26
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
93,
102
]
} |
the activity of netilmicin against a variety of bacteria was similar to that of gentamicin , sisomicin , and tobramycin , but it was less active than these three drugs against pseudomonas aeruginosa . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
80,
90
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
93,
102
]
} |
well-formed streptomyces colonies were counted more rapidly when a starch casein medium containing antibiotics was supplemented with either magnesium chloride or additional sodium chloride . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
150,
158
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
173,
188
]
} |
asparaginase activity was increased by the addition of l-glutamic acid , l-glutamine , or commercial-grade monosodium glutamate . | NA | {
"id": "C0061472",
"name": "l-glutamic",
"pos": [
55,
65
]
} | {
"id": "C0017797",
"name": "l-glutamine",
"pos": [
73,
84
]
} |
asparaginase activity was increased by the addition of l-glutamic acid , l-glutamine , or commercial-grade monosodium glutamate . | NA | {
"id": "C0061472",
"name": "l-glutamic",
"pos": [
55,
65
]
} | {
"id": "C0037511",
"name": "monosodium glutamate",
"pos": [
107,
127
]
} |
influence of hydrostatic pressure on the effects of the heavy metal cations of manganese , copper , cobalt , and nickel on the growth of three deep-sea bacterial isolates . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
56,
67
]
} | {
"id": "C0024706",
"name": "manganese",
"pos": [
79,
88
]
} |
influence of hydrostatic pressure on the effects of the heavy metal cations of manganese , copper , cobalt , and nickel on the growth of three deep-sea bacterial isolates . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
56,
67
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
91,
97
]
} |
influence of hydrostatic pressure on the effects of the heavy metal cations of manganese , copper , cobalt , and nickel on the growth of three deep-sea bacterial isolates . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
56,
67
]
} | {
"id": "C0009148",
"name": "cobalt",
"pos": [
100,
106
]
} |
influence of hydrostatic pressure on the effects of the heavy metal cations of manganese , copper , cobalt , and nickel on the growth of three deep-sea bacterial isolates . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
56,
67
]
} | {
"id": "C0028013",
"name": "three",
"pos": [
137,
142
]
} |
only 3 of the 188 strains tested fermented beef submaxillary mucin , and none fermented porcine gastric mucin . | NA | {
"id": "C0026682",
"name": "mucin",
"pos": [
61,
66
]
} | {
"id": "C0017135",
"name": "gastric mucin",
"pos": [
96,
109
]
} |
two cases are reported of prolonged hypocalcaemia with tetany in infants born at term , whose mothers had been treated with phenytoin and phenobarbitone in high doses . | NA | {
"id": "C0020598",
"name": "hypocalcaemia",
"pos": [
36,
49
]
} | {
"id": "C0039621",
"name": "tetany",
"pos": [
55,
61
]
} |
both infants presented with jitteriness and tetany in the first and second weeks of life , and in both the hypocalcaemia was resistant to therapy over a longer period . | NA | {
"id": "C0039621",
"name": "tetany",
"pos": [
44,
50
]
} | {
"id": "C0020598",
"name": "hypocalcaemia",
"pos": [
107,
120
]
} |
after prolonged occupation exposure to amorphous silica dust-a product of vaporized crystalline silica ( quartz ) -eleven out of forty workers showed reticular and/or nodular abnormalities in roentgenograms of the chest . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
49,
55
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
105,
111
]
} |
intravenous injection of endotoxin ( lps ) from s. typhimurium ( 3,3 microng per kg body weight ) or e. coli o111b4 ( 0,1 microng per kg body weight ) caused fever and stasis of the forestomach contractions in conscious goats . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
25,
34
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
37,
40
]
} |
when insulin or any peptide hormone binds to its receptor on the surface of a target cell , it initiates a series of biochemical steps that ultimately lead to the characteristic action of the hormone . | NA | {
"id": "C0597192",
"name": "peptide hormone",
"pos": [
20,
35
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
192,
199
]
} |
the presence of an idiopathic prolapse of the mitral valve was demonstrated , as well as the familial nature of the condition , and the fact that the syncopal attacks were caused by ventricular tachycardia , the case report is followed by a discussion of the cardiac arrhythmias which are likely to accompany this particular mitral lesion , the difficulties in treatment which arise , and finally the danger of sudden death by ventricular fibrillation inherent in this condition , a danger which it is stille difficult to quantify . | NA | {
"id": "C0003811",
"name": "cardiac",
"pos": [
259,
266
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
427,
451
]
} |
cell-free extracts of d-fructose grown cells of marine species of alcaligenes as well as pseudomonas marina contained an activity which catalyzed a p-enolpyruvate-dependent phosphorylation of d-fructose in the 1-position as well as activities of the following enzymes : 1-p-fructokinase , fructose-1,6-p2 aldolase , ppi-dependent 6-p-fructokinase , fructokinase , glucokinase , p-hexose isomerase , glucose-6-p dehydrogenase , 6-p-gluconate dehydrase , and 2-keto-3-deoxy-6-p-gluconate aldolase . | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
24,
32
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
380,
386
]
} |
the utilization of carnitine and carnitine derivatives ( o-acylcarnitines , carnitine carboxylderivatives ) and structure-related trimethylammonium-compounds ( betaines and nitrogen-bases ) by acinetobacter calcoaceticus was studied by means of the control of growth and the quantitative detection of metabolites . | NA | {
"id": "C0007258",
"name": "carnitine",
"pos": [
19,
28
]
} | {
"id": "C1563845",
"name": "trimethylammonium-compounds",
"pos": [
130,
157
]
} |
the utilization of carnitine and carnitine derivatives ( o-acylcarnitines , carnitine carboxylderivatives ) and structure-related trimethylammonium-compounds ( betaines and nitrogen-bases ) by acinetobacter calcoaceticus was studied by means of the control of growth and the quantitative detection of metabolites . | NA | {
"id": "C1563845",
"name": "trimethylammonium-compounds",
"pos": [
130,
157
]
} | {
"id": "C0005304",
"name": "betaines",
"pos": [
160,
168
]
} |
the h-agglutinin titres of animals aged threemonths in a calf herd with salmonelloses in which all animals had been orally smd-immunised were close to those recorded from calves in stocks with no salmonellosis occurrence . | NA | {
"id": "C0036117",
"name": "salmonelloses",
"pos": [
72,
85
]
} | {
"id": "C0036114",
"name": "salmonellosis",
"pos": [
196,
209
]
} |
presentation of three such cysts , including an intramedullary epidermoid cyst , a lumbosacral subcutaneous enteric cyst that has an epithelium resembling ependyma , and a hypophyseal duct cyst , illustrates typical problems encountered . | NA | {
"id": "C0014511",
"name": "epidermoid cyst",
"pos": [
63,
78
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
189,
193
]
} |
treatment with 5-iodo-2'-deoxyuridine ( iudr ) of the heterokaryons or of the latently infected mouse cells , prior to their fusion with human cells , could induce the appearance of immunoflourescent elements , characterised as late antigens , and of infectious virus . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
25,
37
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
40,
44
]
} |
besides the main glycoproteins with an apparent molecular weight of 100,000 ( peak i ) the antisera precipitate glycoproteins in a region of an apparent mol . wt . of 60,000 -- 80,000 ( peak ii ) , which were resolved into distinct glycoprotein species only by antibody-containing cerebrospinal fluids . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
91,
99
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
261,
269
]
} |
our results indicate that the most part of bronchial antibody was produced locally , since the ratio of ig concentration to antibody titre of each ig class was consistently higher for bronchial washings than for sera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
53,
61
]
} | {
"id": "C0021017",
"name": "ig class",
"pos": [
147,
155
]
} |
ade-h and ade-i are two auxotrophic mutants of chinese hamster ovary ( cho-k1 ) cells which specifically require adenine as the purine source to grow . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
113,
120
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
128,
134
]
} |
these are serine and threonine ( which make up 40-50 % of the molar amino acid composition ) , glutamic acid , glycine alanine and valine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
68,
78
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
111,
118
]
} |
these are serine and threonine ( which make up 40-50 % of the molar amino acid composition ) , glutamic acid , glycine alanine and valine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
68,
78
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
119,
126
]
} |
the carbohydrate side chains in glycoprotein a are composed of about two-thirds monosaccharide and one-third disaccharide residues , whereas those of glycoprotein b are more complex . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
4,
16
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
80,
94
]
} |
the variation with ph of the dissociation constant for the enzyme-nadh complex , calculated from the initial-rate data , indicates that the enzyme possesses a group with pk7.1 in the free enzyme and pk8.7 in the complex . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
59,
65
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
188,
194
]
} |
the ph-dependences of the second-order rate constants for inactivation of the enzyme by diethyl pyrocarbonate were determined for the free enzymes ( pk7.1 ) , the enzyme-nad+ complex ( pk approx . 7.1 ) and the enzyme-nadh complex ( pk approx . 8.4 ) . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
139,
146
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
211,
217
]
} |
however , 12 of the amino acid residues in the positions of identity are glycine residues occurring in the repeating triplet sequence gly-x-y . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
20,
30
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
134,
137
]
} |
chromatographically pure porphyrin esters free from metalloporphyrins were titrated with cu2+ to determine the molar amount of porphyrin present . | NA | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
52,
69
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
127,
136
]
} |
a new amino acid , 3- ( 2,5-ss-dicysteinyl-3,4-dihydroxyphenyl ) alanine , from the tapetum lucidum of the gar ( lepisosteidae ) and its enzymic synthesis . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
6,
16
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
65,
72
]
} |
tyrosinase oxidation of l-dopa in the presence of an excess of l-cysteine yielded , in addition to known 5- and 2-s-cysteinyldopa , the same amino acid as that isolated from the eye of the gar , thus confirming the gross structure . | NA | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
63,
73
]
} | {
"id": "C0010665",
"name": "cysteinyldopa",
"pos": [
116,
129
]
} |
the natural amino acid is therefore formulated as 3- ( 2,5-ss-dicysteinyl-3,4-dihydroxyphenyl ) alanine ( 2,5-ss-dicysteinyldopa ) , which may be formed by two consecutive additions of cysteine , first to dopaquinone and then to 5-s-cysteinyldopaquinone . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
12,
17
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
96,
103
]
} |
hepatic putrescine and spermidine concentrations also varied during rehabilitation , but permine concentration remained relatively constant . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
8,
18
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
34,
48
]
} |
when ascites cells were incubated with [ 32p ] pi , this protein became labelled , indicating that it is a phosphoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
57,
64
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
107,
121
]
} |
the half-life of hamster fibroblast beta-d-glucuronidase ( ec 3.2.1.31 ) was estimated to be 4-5 days by measuring the decay with time of the radioactivity in beta-d-glucuronidase isolated from cells grown in the presence of 14c-labelled amino acids . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
25,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
194,
199
]
} |
of the remaining amino acids studied , only l-norvaline , l-valine , l-norleucine , l-serine and l-2,4-diamino-n-butyrate significantly inhibited l-alanine uptake . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
17,
28
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
146,
155
]
} |
the mercapturic acid was excreted in the urine of rats dosed with benzyl isothiocyanate or its gsh , cysteinyl-glycine or cysteine conjugate , and was isolated as the dicyclohexylamine salt . | NA | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
4,
20
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
122,
130
]
} |
the properties of the enzyme have been compared with glycerylphosphinicocholine diesterase ( ec 3.1.4.2 ) , which is also present in the isolated enzyme complex , and it is concluded that the enzymes have separate identities . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
146,
160
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
192,
199
]
} |
the deposition of protein in the subcellular fraction corresponding to the density of adult myelin , the appearance of basic protein characteristic myelin , the change in proportions of the individual myelin proteins , the appearance and distribution of the myelin marker 2':3'-cyclic nucleotide3'-phosphohydrolase , and the results of morphological studies of purified myelin are compared . | NA | {
"id": "C0014063",
"name": "basic protein",
"pos": [
119,
132
]
} | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
201,
216
]
} |
however , another protein band was detected , which after incubation with cycloheximide disappeared rapidly , the reaction following first-order kinetics , with a half-life of about 11 min . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
145,
153
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
163,
172
]
} |
it was concluded that mg2+ ions are bound bivalently between anionic centres in the walls and that the incorporation of teichoic acid or teichuronic acid into the walls gives rise to similar ion-binding and charged properties . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
27,
31
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
61,
68
]
} |
the sequences of 42 amino acids around the phosphorylation site on the alpha-subunit and of 14 amino acids around the phosphorylation site on the beta-subunit were shown to be : alpha-subunit phe-arg-arg-leu-ser ( p ) -ile-ser-thr-glu-ser-glx-pro-asx-gly-gly-his-ser-leu-gly-a la-asp-leu-met-ser-pro-ser-phe-leu-ser-pro-gly-thr-ser-val-phe ( ser , pro , gly ) his-t hr-ser-lys ; | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
20,
31
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
354,
357
]
} |
these findings , taken with the observation that phosphorylase phosphatase , beta-phosphorylase kinase phosphatase , glycogen synthase phosphatase-1 and glycogen synthase phosphatase-2 activities co-purified up to the sephadex g-200 step , suggest that a single protein phosphatase ( protein phosphatase-iii ) catalyses each of the dephosphorylation reactions that inhibit glycogenolysis or stimulate glycogen synthesis . | NA | {
"id": "C0031714",
"name": "phosphorylase phosphatase",
"pos": [
49,
74
]
} | {
"id": "C0031686",
"name": "protein phosphatase",
"pos": [
284,
303
]
} |
these findings , taken with the observation that phosphorylase phosphatase , beta-phosphorylase kinase phosphatase , glycogen synthase phosphatase-1 and glycogen synthase phosphatase-2 activities co-purified up to the sephadex g-200 step , suggest that a single protein phosphatase ( protein phosphatase-iii ) catalyses each of the dephosphorylation reactions that inhibit glycogenolysis or stimulate glycogen synthesis . | NA | {
"id": "C0017933",
"name": "glycogen synthase phosphatase",
"pos": [
117,
146
]
} | {
"id": "C0031686",
"name": "protein phosphatase",
"pos": [
284,
303
]
} |
inhibitory effect of xanthines on the incorporation of [ 14c ] valine into proteins and on the secretion of albumin in isolated parenchymal rat liver cells . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
75,
83
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
108,
115
]
} |
radioactive gold and yttrium particles induced a significant increase of hyaluronic acid synthesis rate ( pg/cell/day ) and inhibited fibroblast growth . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
109,
113
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
134,
144
]
} |
antimicrobial activity of 3-carbamoyloxymethyl-7-alpha-methoxy-7- [ 2- ( 2-thienyl ) -acetamido ] -3-cephem-4-carb oxylic acid ( cefoxitin ) , a new semisynthetic cephamycin antibiotic , was studied in comparison with that of cefazolin and cefalotin . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
129,
138
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
163,
173
]
} |
is-elements also serve as parts of transposons ( dna structures capable to be transposed from one chromosome to another and carrying a gene for the resistance to an antibiotic or heavy metals ) . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
3,
11
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
179,
191
]
} |
as the extreme case of self-organisation , structural genes of different enzymes might have been fused in the course of evolution , giving rise to multifunctional enzymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
73,
80
]
} | {
"id": "C3658346",
"name": "multifunctional enzymes",
"pos": [
147,
170
]
} |
7- ( 3- [ 2- ( 3,5-dihydroxyphenyl ) -2-hydroxy-ethylamino ] -propyl ) -theophylline ( reproterol , d 1959 , bronchospasmin ) was developed as a bronchospasmolytic agent from the structure class of the phenylethyl-aminoalkyl-xanthines . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
72,
84
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
225,
234
]
} |
renal elimination in the dog and rabbit after i.v . application seems to be the main route of excretion ( dog 57 % , rabbit 66 % ) , while in the rat there is 58 % fecal elimination . | NA | {
"id": "C1373187",
"name": "renal elimination",
"pos": [
0,
17
]
} | {
"id": "C1373186",
"name": "route of excretion",
"pos": [
85,
103
]
} |
renal elimination in the dog and rabbit after i.v . application seems to be the main route of excretion ( dog 57 % , rabbit 66 % ) , while in the rat there is 58 % fecal elimination . | NA | {
"id": "C1373186",
"name": "route of excretion",
"pos": [
85,
103
]
} | {
"id": "C1373190",
"name": "fecal elimination",
"pos": [
164,
181
]
} |
new theophylline and theobromine derivatives are synthetized from the beta-phenylethylaminoalkyl-xanthines , whose phenyl substituent is substitutent by one or two hydroxyl groups and partially also by other substituents . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
4,
16
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
97,
106
]
} |
new theophylline and theobromine derivatives are synthetized from the beta-phenylethylaminoalkyl-xanthines , whose phenyl substituent is substitutent by one or two hydroxyl groups and partially also by other substituents . | NA | {
"id": "C0039763",
"name": "theobromine",
"pos": [
21,
32
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
97,
106
]
} |
the effect of cholesterol and cholesterol ester content of aortas on the dynamic mechanical properties of these tissues was studied in rabbits during development of atherosclerosis . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
30,
47
]
} |
after grading the aortas for lesions , one-half of each aorta was used for the determination of cholesterol and cholesterol ester content while the other half was used for the determination of viscoelastic properties . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
96,
107
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
112,
129
]
} |
the serum levels of cholesterol and cholesterol ester , although increased steadily with the cholesterol feeding , did not show any direct correlation with the viscoelastic properties of the aortas . | NA | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
20,
31
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
93,
104
]
} |
cyclic amp , and its derivatives n6-monobutyryl cyclic amp and dibutyryl cyclic amp , have been found to inhibit the proliferation of trophoblast cells of the bewo cell line in vitro . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
0,
10
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic",
"pos": [
63,
79
]
} |
in separate experiments with 4 of these tumours , equivalent tumour-bearing mice had their tumours surgically excised and were observed for the development of regional nodal corresponding frequency of tumour formation by transplanted nodes . | NA | {
"id": "C0027659",
"name": "experiments",
"pos": [
12,
23
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
201,
207
]
} |
the rbp is a specific transport protein and its level in plasma reflects the amount of vitamin a available to the tissues . | NA | {
"id": "C0035342",
"name": "rbp",
"pos": [
4,
7
]
} | {
"id": "C0007292",
"name": "transport protein",
"pos": [
22,
39
]
} |
in citrated human platelet-rich plasma , ampicillin and oxacillin inhibited adp-induced aggregation to the same extent as similar concentrations of penicillin g ; | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
41,
51
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
148,
160
]
} |
in suspensions of washed platelets , however , ampicillin was less inhibitory than penicillin g or oxacillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
47,
57
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
83,
95
]
} |
these results indicate that benzene ( or a metabolite ) either competes with pyridoxal phosphate at ala synthetase or competes with pyridoxine for pyridoxal phosphokinase . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
77,
96
]
} | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
132,
142
]
} |
evidence for rapid loss of newly synthesized haemoglobin s molecules in sickle cell anaemia and sickle cell trait . | NA | {
"id": "C0002895",
"name": "sickle",
"pos": [
72,
78
]
} | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
96,
113
]
} |
the present study indicates that newly completed haemoglobin s molecules rather than free betas-chains are preferentially bound to the reticulocyte stroma of individuals with sickle cell trait and sickle cell anaemia . | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
175,
192
]
} | {
"id": "C0002895",
"name": "sickle cell anaemia",
"pos": [
197,
216
]
} |
a patient is described who had two pregnancies complicated by severe pre-eclampsia in the second trimester which resulted in intrauterine death . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
35,
46
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
90,
106
]
} |
in experimental rabbits heterologous soluble lens proteins consisting of alpha- , beta- , and gamma-crystallins were found to be antigenic ; | NA | {
"id": "C0010422",
"name": "lens proteins",
"pos": [
45,
58
]
} | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
94,
111
]
} |
some of the antibodies in potent lens antisera cross-reacted with mitochondria , endoplasmic reticulum ( i.e. , microsomes ) , contractile organelles , and cell nuclei . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
12,
22
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
38,
46
]
} |
alternatively , the failure of gamma-crystallins to induce antibody production may be due to intermolecular antigenic competition with other crystallins . | NA | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
31,
48
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
141,
152
]
} |
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