text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the fatty acid composition of ffa resembled that of the backfat triglycerides in fasting and during norepinephrine infusion but not in the fed state . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015688",
"name": "fatty acid",
"pos": [
4,
14
]
} |
the biosynthetic decarboxylase was compared with the biodegradative ornithine decarboxylase [ applebaum , d. , et al . ( 1975 ) , biochemistry 14 , 3675 ] . | NA | {
"id": "C0007054",
"name": "decarboxylase",
"pos": [
17,
30
]
} | {
"id": "C0029282",
"name": "ornithine decarboxylase",
"pos": [
68,
91
]
} |
these cd and esr results are taken to suggest that one aspect of the inactivation by nbs oxidation may be a conversion of the pseudosquare planar copper complex in the native enzyme to a more distorted , towards tetrahedral , complex in the inactivated enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
175,
181
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
226,
233
]
} |
the lipid fatty acid composition of the cytoplasmic membranes of escherichia coli can be varied by growing an unsaturated fatty acid auxotroph in the presence of different fatty acid supplements . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
10,
20
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
110,
132
]
} |
in the hemagglutination assays , ricinus communis i ( rca1 ) and ii ( rcaii ) , concanavalin a ( con a ) , and the agglutinins from peanut ( pna ) , soybean ( sba ) , wheat germ ( wga ) , and limulus polyphemus ( lpa ) were tested with several concentrations of switterionic , cationic , anionic , and nonionic detergents . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
0,
1
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
288,
295
]
} |
by comparison of the crt curves of the in vitro rna with that of 70s viral rna , the content of viral sequences is found to be 1.3 % in nuclei product and 0.24 % in chromatin product which is lower than the 2.5 % found in chromatin associated rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
69,
78
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
243,
246
]
} |
this latter value , however , is very close to the in vivo viral rna content in pulse-labeled [ 3h ] rna of the infected cells . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
59,
68
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
101,
104
]
} |
the factors appear to differ from the initiation factors , the elongation factor ef-t , and ribosomal proteins . | NA | {
"id": "C0030943",
"name": "initiation factors",
"pos": [
38,
56
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
92,
110
]
} |
in the bioassay ( inhibition of electrically induced contractions of the mouse vas deferens ) [ 1-o-methyltyrosine,5-methionine ] enkephalin , [ 1-n-methyltyrosine,5-methionine ] enkephalin , [ 4-tryptophan,5-methionine ] enkephalin , and [ 5-methionine sulfoxide ] enkephalin possess , respectively , 0.4 , 21 , 27 , and 67 % activity of [ 5-methionine ] enkephalin . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
130,
140
]
} | {
"id": "C0014295",
"name": "5-methionine ] enkephalin",
"pos": [
115,
140
]
} |
antibodies that react specifically with segments 1-13 , 31-79 , and 80-124 of native ribonuclease , as they are folded , were purified by affinity chromatography , using antiserum to native ribonuclease and columns to which the ribonuclease fragments were attached . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
170,
179
]
} |
cell surface glycolipids of normal human fibroblasts and nctc2071 cells ( transformed mouse fibroblasts ) were labeled by incubating the intact cells with either galactose oxidase or sodium periodate , followed by reduction of the oxidized sugar residues with nab3h4 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
227,
230
]
} |
maximal binding of choleragen ( 5 x 10 ( 5 ) molecules of [ 125i ] choleragen per cell ) completely prevented cholevented oxidation of gm1 in intact fibroblasts by galactose oxidase but only partially protected the sialic acid moiety of gm1 from oxidation by periodate . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
82,
86
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
149,
160
]
} |
the fluorescence of the nbm or nsm coupled to the sulfhydryl group on the enzyme was quenched by binding to the enzyme of the substrate pyruvate the coenzyme thiamine diphosphate , the coenzyme analogue thiochrome diphosphate , the regulatory ligands acetyl-coa , gtp , and phosphoenolpyruvate , and the acetyl-coa analogue , ans . | NA | {
"id": "C0039848",
"name": "thiamine diphosphate",
"pos": [
158,
178
]
} | {
"id": "C0009235",
"name": "coenzyme analogue",
"pos": [
185,
202
]
} |
it was found that , unlike cyanide , azide anion would not perturb the epr spectrum of ag2 , cu2 protein . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
27,
34
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
43,
48
]
} |
the predominant forms in the cytosol will depend on the concentration of the constituent subunits , the ph , the concentration of ions ( particularly divalent anions ) , and the temperature . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
130,
134
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
159,
165
]
} |
treatment of transformed fibroblasts in monolayer with 25 micronm gmp ( et ) gmp ( et ) u results in a 40 % inhibition of cellular protein synthesis with a concurrent slight increase in cellular rna synthesis during the first 4 h . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
25,
36
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
186,
194
]
} |
this improved preparation contains two c-type cytochromes in the ratio p-960 : cytochrome c-558 : cytochrome c-553 of 1:2:2 to 3 . | NA | {
"id": "C1256752",
"name": "c-type cytochromes",
"pos": [
39,
57
]
} | {
"id": "C0010749",
"name": "cytochrome",
"pos": [
98,
108
]
} |
phospholipase a2 present in a highly purified , potently bactericidal , fraction from rabbit graulocytes produces net bacterial phospholipid degradation during killing of a phospholipase a-less strain of escherichia coli . | NA | {
"id": "C0031667",
"name": "phospholipase a2",
"pos": [
0,
16
]
} | {
"id": "C0031672",
"name": "a phospholipase",
"pos": [
171,
186
]
} |
from the analysis of fatty acids , it was shown that the content of unsaturated fatty acids of pl42 ( kcl ) is only 9 % of the total fatty acids , while that of pl28 is 54 % . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
68,
91
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
133,
138
]
} |
the rna preparations used were 25 , 18 , and 5 s rrna and 4 s rna , purified by gel electrophoresis , and poly ( a ) -containing rna purified by oligo- ( dt ) -cellulose chromatography . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
49,
53
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
129,
132
]
} |
the molecular weights of the 25 s and 18 s rrnas , calculated from the mobility in formamide-acrylamide gels relative to escherichia coli rna , are 1.25 - 10 ( 6 ) and 0.64 - 10 ( 6 ) . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
43,
48
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
138,
141
]
} |
the percentage of the genome , calculated on the basis of double-stranded dna , coding for these rnas and the estimated number of genes per haploid dna amount are approximately 0.46 % and 1100 for 25 s plus 18 s rrna , 0.032 % and 3600 for 5 s rrna and 0.072 % and 13 000 for 4 s rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
212,
216
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
280,
283
]
} |
the tm of the dna - rna hybrids in 1 x ssc is 89 degrees c for 25 s rrna , 85 degrees c for 5 s rrna and 82 degrees c for 4 s rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
68,
72
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
126,
129
]
} |
5 and 4 s rna preparations contain fragments which hybridise to sequences complementary to high-molecular-weight rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
10,
13
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
113,
117
]
} |
the rna which was sensitive to this drug and hence may be assumed to be messenger rna was distributed mainly between 18 and 4 s . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
4,
7
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
72,
85
]
} |
high molecular weight nuclear pre-messenger rna ( pre-mrna or hnrna ) isolated from ehrlich ascites carcinoma cells contains besides moderately long ( 100 -- 200 base pairs ) snap-back double-stranded structures , also longer double-stranded structure containing at least 300 -- 800 base pairs . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
22,
29
]
} | {
"id": "C0035695",
"name": "hnrna",
"pos": [
62,
67
]
} |
both the mitochondrial and cytosol nacl-insoluble rna fractions were found to contain two major radioactive components , corresponding to the large ( 26s ) and small ( 18s ) rrna species . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
50,
53
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
174,
178
]
} |
polyribosomal rna prepared from normal and regenerating liver was chromatographed on poly ( u ) -sepharose to obtain rrna and poly ( a ) -rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
117,
121
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
138,
141
]
} |
nuclear steady-state rna and polysomal rna of chicken immature red blood cells were isolated and separated on formamide sucrose gradients . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
0,
7
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
39,
42
]
} |
sphericanl macroporous reactive carriers capable of forming covalent bonds with amino acids and proteins were prepared by the suspension copolymerization of 2-hydroxyethyl methacrylate , ethylene dimethacrylate and p-nitrophenyl esters of methacrylic acid and methacryloyl derivatives of glycine , beta-alanine and epsilon-aminocaproic acid . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
80,
91
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
288,
295
]
} |
( na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) was purified from human cadaver renal tissue and exhibited a linear reaction rate with time . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
2,
4
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
23,
43
]
} |
at ph 8.87 , there is evidence that l-glutamate binds less tightly to the enzyme and to the enzyme-nadp+ complex than at lower ph values . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
74,
80
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
92,
98
]
} |
though histidine is the best substrate for hcn production , other naturally occurring aromatic amino acids ( viz . tyrosine , phenylalanine and tryptophan ) can also serve as hcn precursors with these enzyme systems . | NA | {
"id": "C0301713",
"name": "aromatic amino",
"pos": [
86,
100
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
115,
123
]
} |
though histidine is the best substrate for hcn production , other naturally occurring aromatic amino acids ( viz . tyrosine , phenylalanine and tryptophan ) can also serve as hcn precursors with these enzyme systems . | NA | {
"id": "C0301713",
"name": "aromatic amino",
"pos": [
86,
100
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
126,
139
]
} |
though histidine is the best substrate for hcn production , other naturally occurring aromatic amino acids ( viz . tyrosine , phenylalanine and tryptophan ) can also serve as hcn precursors with these enzyme systems . | NA | {
"id": "C0301713",
"name": "aromatic amino",
"pos": [
86,
100
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
144,
154
]
} |
the distribution of soluble arylsulfatase ( aryl-sulfate sulfohydrolases , ec 3.1.6.1 ) in human tissues was investigated by deae-cellulose chromatography , all tissues examined contained arylsulfatase a and arylsulfatase b . | NA | {
"id": "C0003940",
"name": "aryl-sulfate sulfohydrolases",
"pos": [
44,
72
]
} | {
"id": "C0007804",
"name": "arylsulfatase a",
"pos": [
188,
203
]
} |
the distribution of soluble arylsulfatase ( aryl-sulfate sulfohydrolases , ec 3.1.6.1 ) in human tissues was investigated by deae-cellulose chromatography , all tissues examined contained arylsulfatase a and arylsulfatase b . | NA | {
"id": "C0003940",
"name": "aryl-sulfate sulfohydrolases",
"pos": [
44,
72
]
} | {
"id": "C0376159",
"name": "arylsulfatase b",
"pos": [
208,
223
]
} |
in addition , brain singularly contained significant quantities ( 15-25 % of total arylsulfatase ) of a minor anionic arylsulfatase from designated arylsulfatase bm , whereas only trace amounts of arylsulfatase bm were found in liver , kidney , testis and placenta . | NA | {
"id": "C0007804",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
197,
210
]
} |
arylsulfatase b and arylsulfatase bm had equal activity toward methyl-umbelliferyl sulfate , nitrocatechol sulfate and a physiological substrate udp-n-acetylgalactosamine 4-sulfate , but both forms were inactive toward the arylsulfatase a substrates cerebroside sulfate and ascorbic acid 2-sulfate . | NA | {
"id": "C0376159",
"name": "arylsulfatase b",
"pos": [
0,
15
]
} | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
223,
236
]
} |
arylsulfatase b and arylsulfatase bm had equal activity toward methyl-umbelliferyl sulfate , nitrocatechol sulfate and a physiological substrate udp-n-acetylgalactosamine 4-sulfate , but both forms were inactive toward the arylsulfatase a substrates cerebroside sulfate and ascorbic acid 2-sulfate . | NA | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
0,
13
]
} | {
"id": "C0007804",
"name": "arylsulfatase a",
"pos": [
223,
238
]
} |
purified preparations of placental arylsulfatase b , brain arylsulfatase bm , and urinary arylsulfatase a did not hydrolyze estrone sulfate , dehydroepiandrosterone sulfate or pregnenolone sulfate . | NA | {
"id": "C0376159",
"name": "arylsulfatase b",
"pos": [
35,
50
]
} | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
90,
103
]
} |
purified preparations of placental arylsulfatase b , brain arylsulfatase bm , and urinary arylsulfatase a did not hydrolyze estrone sulfate , dehydroepiandrosterone sulfate or pregnenolone sulfate . | NA | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
35,
48
]
} | {
"id": "C0007804",
"name": "arylsulfatase a",
"pos": [
90,
105
]
} |
although the physico-chemical properties differed , arylsulfatase b and arylsulfatase bm appear to be functionally equivalent as well as generically related . | NA | {
"id": "C0376159",
"name": "arylsulfatase b",
"pos": [
52,
67
]
} | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
72,
85
]
} |
the association and dissociation rate constants for the interaction of [ 3h ] -ouabain with partially purified rat brain ( na+ , k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) in vitro were estimated from the time course of the [ 3h ] -ouabain binding observed in the presence of na+ , mg2+ and atp by a polynomial approximation-curve-fitting technique . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
123,
125
]
} | {
"id": "C0001473",
"name": "atp",
"pos": [
299,
302
]
} |
the effect of free mg2+ , mgedta and mgcdta on the phofphorylation of the ( na+ + k+ ) -activated atpase ( atp phosphohydrolase , ec 3.6.1.3 ) has been studied . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
76,
78
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
107,
127
]
} |
atp plus mg2+ plus na+ supported [ 3h ] ouabain binding to canine left ventricular tissue homogenates and microsomal ( na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) activity from the same tissue were measured . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
19,
21
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
140,
160
]
} |
phosphatidylcholine and sphingomyelin contained high amounts of palmitic acid and low levels of c20 and c22 unsaturated fatty acids , and sphingomyelin contained c24 fatty acids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
108,
131
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
166,
177
]
} |
the ability of a series of 18 carbon acetylenic fatty acids to fulfill the unsaturated fatty acid requirements of escherichia coli and saccharomyces cerevisiae was investigated . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
48,
59
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
75,
97
]
} |
we also determined the changes in protein and lipid concentrations of the different lipoprotein fractions . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
46,
51
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
84,
95
]
} |
the injection of triton wr-1339 resulted in a linear increase with time in the concentration of protein and triacylglycerol in the very low density ( chylomicron-free and d less than 1.006 ) lipoproteins , but there was an increase in the ratio of traicylglycerol to protein in that fraction . | NA | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
150,
161
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
191,
203
]
} |
there was an immediate ( by 5 min ) drop of 70 % or more in high density ( d 1.063-1.21 ) lipoprotein protein , but the lipids except triacylglycerol remained unchanged . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
90,
101
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
120,
126
]
} |
bile salts inhibited the formation of radioactive cholesterol esters in incubations of either rat liver homogenates or rat liver microsomes containing [ 14c ] cholesterol . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
50,
68
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
159,
170
]
} |
to determine if the cholesterol of high density lipoprotein ( hdl ) displays similar thermal behavior , the human lipoprotein and its extracted lipid have been examined by differential scanning calorimetry , low angle x-ray scattering and polarizing microscopy . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
48,
59
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
144,
149
]
} |
the first component ( peak temperature=71 degreesc ) corresponds to a selective release of apoprotein a-1 from the lipoprotein , and the second component ( peak temperature=90 degreesc ) to a more generalized disruption of lipoprotein structure with release of cholesterol ester and apoprotein a-2 . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
115,
126
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
294,
295
]
} |
the first component ( peak temperature=71 degreesc ) corresponds to a selective release of apoprotein a-1 from the lipoprotein , and the second component ( peak temperature=90 degreesc ) to a more generalized disruption of lipoprotein structure with release of cholesterol ester and apoprotein a-2 . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
24,
25
]
} | {
"id": "C0085833",
"name": "apoprotein a",
"pos": [
283,
295
]
} |
monolayers of hamster fibroblasts ( bhk cells ) were incubated in eagle 's minimal essential medium under conditions where an increase in the levels of all cellular bisphosphatidic acids takes place . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
22,
33
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
156,
164
]
} |
enzyme preparations from sheep seminal vesicles display an enhanced ability to synthesize prostaglandins , particularly prostaglandin f from polyunsaturated fatty acids if alpha-lipoic acid is present in the incubation mixture prior to the addition of fatty acid . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
90,
104
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
120,
135
]
} |
this method does not require lipid extraction from silica gel of thin-layer chromatography , and allows a quantitative assessment of the sphingoglycolipids and galactosyl glycerides using a small amount of testicular tissue . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
29,
34
]
} | {
"id": "C0017860",
"name": "glycerides",
"pos": [
171,
181
]
} |
this protein , the most retarded fraction of this venom on a cation-exchange resin , is a homologue of bovine pancreatic trypsin inhibitor consisting of a single chain of 57 amino acid residues containing six half-cystine residues . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0003641",
"name": "bovine pancreatic trypsin inhibitor",
"pos": [
103,
138
]
} |
structural alterations of the haem vicinity of the high-spin derivatives of bovine ferric myoglobin ( metmyoglobin ) and human haemoglobin and the changes of the interaction with inositol hexaphosphate induced by ethanediol were monitored by solvent-proton magnetic relaxation . | NA | {
"id": "C0027078",
"name": "myoglobin",
"pos": [
90,
99
]
} | {
"id": "C0025852",
"name": "metmyoglobin",
"pos": [
102,
114
]
} |
the best correlation of interactions with staining pattern occurs when cationic bridging of acid residues is maximized and supported by favourable ion pair interactions . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
71,
79
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
164,
167
]
} |
only alpha-tocopherol and to a lesser extent alpha-tocotrienol and gamma-tocopherol exhibited competition . alpha-tocopherol acetate , alpha-tocopherol quinone and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid had no effect on binding . | NA | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
5,
21
]
} | {
"id": "C1999896",
"name": "alpha-tocopherol",
"pos": [
135,
151
]
} |
the cyclic amp level in pig skin ( epidermis ) increases markedly after incubation with epinephrine , prostaglandin e , histamine or adenosine 5'-monophosphate . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
4,
14
]
} | {
"id": "C0001413",
"name": "adenosine",
"pos": [
133,
142
]
} |
the incorporation of radioactivity derived from [ 2-14c ] riboflavin into the flavins of rat liver mitochondrial outer membranes was studied . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
58,
68
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
78,
85
]
} |
with the covalently bound flavins , radioactivity was incorporated into the coenzymes for at least 18 h , but the rate of incorporation was much slower . | NA | {
"id": "C0016213",
"name": "flavins",
"pos": [
26,
33
]
} | {
"id": "C0009235",
"name": "coenzymes",
"pos": [
76,
85
]
} |
labeling of both types of flavins after [ 14c ] riboflavin was considerably slower than the incorporation of [ 3h ] leucine into outer membrane proteins . | NA | {
"id": "C0016213",
"name": "flavins",
"pos": [
26,
33
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
48,
58
]
} |
this eliminated the possibility that the above results were restricted to the tritiated precursor and merely a reflection of hydrogen-tritium exchange . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
125,
133
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
134,
141
]
} |
allylbenzene is first oxidized on the benzylic carbon to form 1'-hydroxyallylbenzene , which is further oxidized to form phenyl vinyl ketone , which condenses with the secondary amines piperidine and dimethylamine to form tertiary aminopropiophenones ( mannich bases ) . | NA | {
"id": "C0002508",
"name": "amines",
"pos": [
178,
184
]
} | {
"id": "C0024728",
"name": "mannich bases",
"pos": [
253,
266
]
} |
this proposed metabolic scheme is consistent with the chemical mechanism operative in the synthesis of mannich base from allylbenzene via chromic acid oxidation followed by amine addition . | NA | {
"id": "C0024728",
"name": "mannich base",
"pos": [
103,
115
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
173,
178
]
} |
the controversy about the presence of the pentose arabinose in brain hyaluronate was reinvestigated using modern analytical tehcnics . | NA | {
"id": "C0030894",
"name": "pentose",
"pos": [
42,
49
]
} | {
"id": "C0003682",
"name": "arabinose",
"pos": [
50,
59
]
} |
gas-liquid chromatography of the aldononitrile peracetate of the pentose isolated by preparative paper chromatography gave a single distinct peak , corresponding to standard arabinose on three columns packed with three different phases . | NA | {
"id": "C0030894",
"name": "pentose",
"pos": [
65,
72
]
} | {
"id": "C0003682",
"name": "arabinose",
"pos": [
174,
183
]
} |
analysis of the isolated pentose with the help of the enzymes l-arabinose isomerase and l-ribulose kinase , which are specific for their substrates , further established its identity as l-arabinose . | NA | {
"id": "C0030894",
"name": "pentose",
"pos": [
25,
32
]
} | {
"id": "C0003682",
"name": "arabinose",
"pos": [
188,
197
]
} |
no changes in the activity of lysosomal enzymes in fibroblasts and culture medium is observed in the case of inoculation of cells with a killed agents , as well as after contact of cells with a suspension of normal chick embryo yolk sacs . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
181,
186
]
} |
serine , threonine , alanine and valine are found to prevail in amino acid composition of the fraction iv , its molecular weight being 39000 . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
21,
28
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
64,
74
]
} |
the potent inhibition of phospholipase activity in the presence of phosphocholine , choline , acetylcholine , thiocholine and acylthiocholines suggests the existence of an anionic center siii in the active site . | NA | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
67,
81
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
134,
141
]
} |
the potent inhibition of phospholipase activity in the presence of phosphocholine , choline , acetylcholine , thiocholine and acylthiocholines suggests the existence of an anionic center siii in the active site . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
74,
81
]
} | {
"id": "C0039883",
"name": "thiocholine",
"pos": [
130,
141
]
} |
the main contribution to the binding of the cathionic lecithin part ( `` '' head '' '' ) with the anionic center siii is probably provided by the ion-ionic interactions . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
98,
103
]
} | {
"id": "C0022023",
"name": "n-ion",
"pos": [
148,
153
]
} |
the incorporation of ( 14c ) lysine ( to characterize the biosynthesis of cellular proteins ) and ( 14c ) glycine ( for silk fibroin ) in free and membrane-bound polyribosomes was studied in fibroin portion of the silk gland of bombyx mori silkworm in the v instar . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
120,
124
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
191,
198
]
} |
the identity of the precursor protein as a form of the purple membrane protein was established in different ways : ( 1 ) the cell proteins were labelled in vivo with 14c-proline during dark aerobic growth , the label was `` '' chased '' '' , and the cells transferred to the illuminated near-anaerobic conditions under which purple membrane is optimally synthesised ( induction conditions ) . | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
20,
37
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
130,
138
]
} |
as examples valinomycin as a carrier model and gramicidin a as a channel former in lipid vesicles and in planar lipid membranes are presented . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
83,
88
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
112,
117
]
} |
the presence of adrenosensitive cells which reacted to the application of different adrenaline ( a ) and noradrenaline ( na ) concentrations by a distinct acceleration of the activity rhythm was demonstrated . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
105,
118
]
} |
stable leukocytosis and lymphocytosis were observed in the peripheral blood of guinea pigs from the 14th day after their sensitization with b. pertussis oil suspension . | NA | {
"id": "C0023518",
"name": "leukocytosis",
"pos": [
7,
19
]
} | {
"id": "C0024282",
"name": "lymphocytosis",
"pos": [
24,
37
]
} |
disc-electrophoretic investigation of proteases of the gastric juice of dogs under normal conditions and in experimental atophan ulcer of the stomach demonstrated that in fasting dogs ulceration was accompanied by marked quantitative changes in the protease spectrum . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
38,
47
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
249,
257
]
} |
against the background of the craniocerebral trauma hemorrhagic shock appeared with a much less blood loss and its course was more severe . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
52,
69
]
} | {
"id": "C0019080",
"name": "blood loss",
"pos": [
96,
106
]
} |
[ antiviral activity of preparations of rna isolated from cells treated with interferon ( messenger rna for an antiviral protein ? ) ] . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
40,
43
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
90,
103
]
} |
these solid wastes were found to adsorb significant amounts of one or more of the heavy metals ( hg , cu , ni , cd , zn ) commonly found in municipal sludge and wastewater . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
82,
94
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
97,
99
]
} |
kinetic analyses of the dose-response curves for the n-methylamino acid in the presence or absence of the convulsant indicated that the number of molecules of the amino acid combining with the receptor site to produce a response was 3 for n-methylgaba , 2 for n-methylglycine , 3 for n-methyltaurine , 3 for n-methylbeta-alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
61,
71
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
321,
328
]
} |
no dysrhythmias developed but at higher concentrations ( 590 micronm ) 2 out of 7 hearts developed dysrhythmias ( extrasystoles ) . | NA | {
"id": "C0003811",
"name": "dysrhythmias",
"pos": [
3,
15
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
114,
127
]
} |
in addition antisera to gc6-t1 za gave a positive pca reaction with gc6-t4 za and za prepared from t1 colonies of six heterologous gonococcal strains suggesting that these strains of n. gonorrhoeae share common antigenic determinants . | NA | {
"id": "C0003320",
"name": "za",
"pos": [
31,
33
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
211,
233
]
} |
although some apparent constant specific activities were obtained for 20alpha-hydroxy-5alpha-pregnan-3-one and 5beta-pregnane-3 , 20-dione , the low levels of 3h associated with these steroids did not permit a definitive identification . | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
117,
125
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
184,
192
]
} |
since gad-positive reaction product can be detected in the somata and dentrites of gaba-ergic neurons which have presynaptic dentrites , it is suggested that these neurons may differ from other gaba-ergic neurons with respect to either transport or metabolism of gad . | NA | {
"id": "C0017785",
"name": "gad",
"pos": [
6,
9
]
} | {
"id": "C0007054",
"name": "gad",
"pos": [
263,
266
]
} |
the hybrid of human lutropin alpha + thyrotropin beta was considerably less active than the natural recombinant ( thyrotropin alpha + beta ) , possibly indicating the presence of some differences in the alpha subunits . | NA | {
"id": "C0076641",
"name": "thyrotropin beta",
"pos": [
37,
53
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
114,
125
]
} |
the km of g1p for phosphorylase a remained constant over the course of inactivation , while the km values of g1p and amp for phosphorylase b increased . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
18,
31
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
125,
140
]
} |
two patients had been treated for malignant lymphoma eight and nine years prior to the onset of skin lesions ( hodgkin 's disease and nodular lymphocytic lymphoma , respectively ) , and cutaneous granulocytic leukemia developed in sites of irradiated skin . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
34,
52
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
111,
129
]
} |
the electron microscopic study demonstrated the former cell type closely resembling the fibroblast and the latter to be more epithelial having very plump cytoplasm with fairly well developed desmosomes . | NA | {
"id": "C0007634",
"name": "cell type",
"pos": [
55,
64
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
88,
98
]
} |
the cyst wall and the septa consist of a superficial layer of cellular fibroblastic and histiocytic tissue in which multinuclear giant cells are present , covering a deeper situated zone of less cellular fibrous tissue . | NA | {
"id": "C0016030",
"name": "cellular fibroblastic",
"pos": [
62,
83
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
195,
203
]
} |
we conclude that the free fatty acids contained in the extracellular fluid provide much of the fatty acid for required cellular lipid synthesis in human leukemic blast cells . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
21,
37
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
95,
100
]
} |
since there is little elongation of incoming palmitate before incorporation into cellular lipids , it may be possible to alter the fatty acid composition of membrane phospholipids by changing the proportion of the various free fatty acids available to the leukemic cells . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
131,
141
]
} | {
"id": "C0015688",
"name": "free fatty",
"pos": [
222,
232
]
} |
the nuclei from phenobarbital-pretreated rats also contained a dna-bound product corresponding to that derived from the binding of benzo ( a ) pyrene 4,5-oxide ( product c ) , but they completely lacked the dna-bound product derived from futher metabolism of 0-hydroxybenzo ( a ) pyrene ( product d ) . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
61,
66
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
207,
210
]
} |
it was found that there are two kinds of pyrimidine nucleoside , monophosphokinase deoxythymidine 5'-monophosphate-deoxyuridine 5'-monophosphate ( dtmp-dump ) kinase and cytidine 5'-monophosphate-deoxycytidine 5'-monophosphate-uridine 5'-monophosphate-doexyuridine 5'-monophosphate ( cmp-dcmp-ump-dump ) kinase , and their molecular weights were calculated to be 46,000 and 26,000 , respectively , by gel filtration . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleoside",
"pos": [
41,
62
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
257,
264
]
} |
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