text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in vivo metabolism of maiq-1 in mice , studied with [ 3'-14c ] maiq-1 showed that relatively slow excretion of this agent occurred , since the cumulative urinary excretion of radioactivity was only 35 % in 48 hr . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
8,
18
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
162,
171
]
} |
spleen cell populations from mice treated with adriamycin or daunorubicin were found to develop a greater complement-independent cellular cytotoxic immune response during culture with allogeneic tumor cells than spleen cells from untreated or cyclophosphamide-treated animals . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
7,
11
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
184,
194
]
} |
the binding of hb antiserum to viable cells was assessed by immunofluorescence and an indirect radiolabeled antibody assay . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
18,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
108,
116
]
} |
these cells , possible precursor cells of thymic lymphocytes , are frequently observed to attach and pass through the basal lamina which coats the thymic rudiment . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
23,
38
]
} |
lw13k2 cells , a clone of a spontaneously in vitro transformed derivative of embryonic lewis rat fibroblastic cells , were studied by phase contrast cine-light microscopy , scanning electron microscopy ( sem ) and transmission electron microscopy ( tem ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
97,
109
]
} |
dibutyryl cyclic amp , cyclic gmp and cyclic amp disrupt slugs of polysphondylium pallidum , while species of dictyostelium are disrupted by only cyclic amp . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
0,
20
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
146,
156
]
} |
regenerating posterior sections of the flatworm , dugesia dorotocephala , were treated with varying concentrations of 5'-adenosine monophosphate ( amp ) , cyclic amp ( camp ) and dibutyryl cyclic amp ( bt2camp ) for 24 h . | NA | {
"id": "C0001413",
"name": "5",
"pos": [
118,
119
]
} | {
"id": "C0001455",
"name": "cyclic",
"pos": [
189,
195
]
} |
regenerating posterior sections of the flatworm , dugesia dorotocephala , were treated with varying concentrations of 5'-adenosine monophosphate ( amp ) , cyclic amp ( camp ) and dibutyryl cyclic amp ( bt2camp ) for 24 h . | NA | {
"id": "C0001455",
"name": "cyclic",
"pos": [
155,
161
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
179,
199
]
} |
the comparison of c12pp and pg expansion data shows the importance of the glycerol residue of pg ionic properties , favouring penetration of cations in the films . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
97,
102
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
141,
148
]
} |
on the contrary such oocytes remain able to undergo meiosis when injected with cytoplasm of maturing oocytes ( mpf ) , with rabbit phosphorylase kinase or with beef protein kinase . | NA | {
"id": "C0031713",
"name": "phosphorylase",
"pos": [
131,
144
]
} | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
165,
179
]
} |
a protein , not antigenically related to the immunoglobulins , has been isolated by affinity chromatography from the serum of rabbits immunized with dinitrophenylated human gamma-globulin . | NA | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
45,
60
]
} | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
173,
187
]
} |
complications such as electrocardiographic hypervoltage , left ventricular hypertrophy , radiogrpahic cardiomegaly , and retinopathy occurred in the placebo group at a rate of 53.1 per 100 subjects compared to 23.8 per 100 in those on active drugs . | NA | {
"id": "C0149721",
"name": "left ventricular hypertrophy",
"pos": [
58,
86
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
102,
114
]
} |
there was cross-reactivity with cocaine ( more reactive than benzoylecgonine ) and other members of the tropane family of alkaloids . | NA | {
"id": "C0009170",
"name": "cocaine",
"pos": [
32,
39
]
} | {
"id": "C0041177",
"name": "tropane",
"pos": [
104,
111
]
} |
there was cross-reactivity with cocaine ( more reactive than benzoylecgonine ) and other members of the tropane family of alkaloids . | NA | {
"id": "C0041177",
"name": "tropane",
"pos": [
104,
111
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
122,
131
]
} |
the effect of lithium nitrate and sodium nitrate on the plasma cholinesterase variants have been shown to be identical in the concentration range 25.0-50.0 mmol/l . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
22,
29
]
} | {
"id": "C0074748",
"name": "sodium nitrate",
"pos": [
34,
48
]
} |
an automated gas-liquid chromatographic technique for the routine determination of phenobarbitone , primidone and phenytoin using a nitrogen-detector is described . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
83,
97
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
100,
109
]
} |
sanfilippo a disease appeared to be the commonest mucopolysaccharidosis occurring in england and sanfilippo b disease , one of the rarest forms . | NA | {
"id": "C0026703",
"name": "mucopolysaccharidosis",
"pos": [
50,
71
]
} | {
"id": "C0026706",
"name": "sanfilippo b disease",
"pos": [
97,
117
]
} |
the main route of elimination is renal excretion of digoxin , which is closely correlated with the glomerular filtration rate . | NA | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
9,
29
]
} | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
33,
48
]
} |
hepatocellular diseases , such as hepatitis , cirrhosis , or hepatic neoplasm , are associated with impaired metabolism of certain drugs , including aminopyrine , whereas cholestasis produced variable effects on aminopyrine metabolism . | NA | {
"id": "C0023895",
"name": "hepatocellular diseases",
"pos": [
0,
23
]
} | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
34,
43
]
} |
hepatocellular diseases , such as hepatitis , cirrhosis , or hepatic neoplasm , are associated with impaired metabolism of certain drugs , including aminopyrine , whereas cholestasis produced variable effects on aminopyrine metabolism . | NA | {
"id": "C0023895",
"name": "hepatocellular diseases",
"pos": [
0,
23
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
46,
55
]
} |
comparison of the clinical picture presented in syrup or fluid extract of ipecac overdose and emetine toxicity in amebiasis treatment permits us to summarize the general characteristics of ipecac alkaloid toxicity as involving primarily gastrointestinal , cardiovascular , and neuromuscular foci . | NA | {
"id": "C0013974",
"name": "emetine",
"pos": [
94,
101
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
196,
204
]
} |
a water soluble and heat labile toxin suggestive of a mycotoxin was demonstrated in water extracts . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
32,
37
]
} | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
54,
63
]
} |
this system involves observing changes in the characteristics of murmurs and abnormal sounds during respiration , the valsalva maneuver , exercise , changes in posture , after pharmacologic agents and during arrhythmias , these techniques will aid in the accurate identification of the origin of the murmur or abnormal sound but do not necessarily indicate the presence or severity of cardiac disease . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
208,
219
]
} | {
"id": "C0018799",
"name": "cardiac",
"pos": [
385,
392
]
} |
in contrast to the effect of the monovalent cations studied , di- or polyvalent cations ( and ag+ cations ) were incapable of producing c-bands , but appeared to stabilize the ba ( oh ) 2-induced reverse-banding pattern , this stabilizing effect was obtainable with relatively low cation concentrations and persisted even when c-band-producing cations were present at the same time . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
33,
51
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
344,
351
]
} |
factors associated with cardiac metastases were ( 1 ) histologic cell type of the tumor , ( 2 ) aggressive therapy , ( 3 ) extent of disease , and ( 4 ) tumor differentiation . | NA | {
"id": "C0027652",
"name": "histologic",
"pos": [
54,
64
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
153,
158
]
} |
because of the high false-positive rate of the perfusion lung scan , we strongly recommend angiographic confirmation of pulmonary embolism when interruption of inferior vena cava is contemplated for the prevention of recurrence of pulmonary embolism . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
130,
138
]
} | {
"id": "C0034065",
"name": "pulmonary",
"pos": [
231,
240
]
} |
compared to controls , mice receiving morphine sulfate ( 10 mg/kg , sc ) 3 hr prior to naloxone had a 28 % increase in naloxone concentration in brain ( 200 to 260 pmol of naloxone per g of brain ) 10 min after 3h-naloxone-hcl ( 0.4 mg/kg , 11.0 micronci/kg , sc ) administration . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
87,
95
]
} | {
"id": "C0700549",
"name": "naloxone-hcl",
"pos": [
214,
226
]
} |
also , if similar morphine-pretreated mice received a second dose of morphine sulfate ( 1.0 mg/kg , sc ) concurrent with 3h-naloxone-hcl , the morphine-induced enhancement of 3h-naloxone concentration in brain was unaltered . | NA | {
"id": "C0700549",
"name": "naloxone-hcl",
"pos": [
124,
136
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
178,
186
]
} |
in prior ( 3 hr ) morphine-treated animals , administration of 3h-naloxone-hcl ( 0.1 mg/kg , 33.3 micronci/kg ) iv resulted in an 11.0 % increase in 3h-naloxone brain concentration after 1 min . | NA | {
"id": "C0700549",
"name": "naloxone-hcl",
"pos": [
66,
78
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
152,
160
]
} |
finally , when morphine pellet-implanted mice ( 75 mg of morphine base , 72 hr ) were administered 3h-naloxone-hcl ( 0.4 mg/kg , 10.0 micronci/kg , sc ) , only a 22.5 % enhancement of 3h-naloxone concentration in brain was obtained , as opposed to a reported 8-fold increase in the potency of naloxone . | NA | {
"id": "C0700549",
"name": "naloxone-hcl",
"pos": [
102,
114
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
293,
301
]
} |
upon stabilization of morphine self-administration , one group continued to self-administer morphine , while two other groups were switched to methadone or 1-alpha-acetylmethadol ( laam ) self-administration for an additional five to ten days . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
143,
152
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
164,
178
]
} |
the sensitivity of the in vitro bioassay was equal to or higher than that of radioimmunoassay , with detection limits of 0.1 miu of human menopausal gonadotropin ( hmg ) or 10 ng of a rhesus pituitary gonadotropin preparation ( ler-1909-2 ) . | NA | {
"id": "C0025326",
"name": "human menopausal gonadotropin",
"pos": [
132,
161
]
} | {
"id": "C0018066",
"name": "pituitary gonadotropin preparation",
"pos": [
191,
225
]
} |
the affinities of steroids for the progesterone receptor were as follows : norethindrone ( ki of 2.3 x 10 ( -9 ) m ) greater than 5alpha-dihydronorethindrone greater than norethindrone acetate greater than lynestrenol greater than 17alpha-ethynyl-estra-4-ene-3beta , 17beta-diol greater than ethynodiol diacetate ( ki of 1.3 x 10 ( -7 ) m ) . | NA | {
"id": "C0028356",
"name": "norethindrone",
"pos": [
75,
88
]
} | {
"id": "C0068980",
"name": "norethindrone acetate",
"pos": [
171,
192
]
} |
the affinities of steroids for the e2 receptor were as follows : ethynodiol diacetate ( ki of 1.3 x 10 ( -7 ) m ) greater than 17alpha-ethynyl-estra-4-ene-3beta , 17beta-diol greater than norethindrone acetate greater than norethindrone greater than 5alpha-dihydronorethindrone greater than lynestrenol ( ki of 8.4 x 10 ( -7 ) m ) . | NA | {
"id": "C0068980",
"name": "norethindrone acetate",
"pos": [
188,
209
]
} | {
"id": "C0028356",
"name": "norethindrone",
"pos": [
264,
277
]
} |
the potentiating effect of perchlorate probably takes place at a step prior to cyclic amp action since it did not affect dbcamp-stimulated secretion . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
79,
89
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
121,
127
]
} |
the growth hormone ( gh ) -releasing effect of thyrotropin-releasing hormone ( trh ) was investigated in rats in which central nervous system ( cns ) -anterior pituitary ( ap ) connections had been experimentally interrupted . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
4,
18
]
} | {
"id": "C0032016",
"name": "anterior",
"pos": [
151,
159
]
} |
the results reveal that in the rat with surgical separation of the anterior pituitary from the cns , a direct gh-releasing effect of trh can be obtained , whereas its prl-releasing effect is no longer observed , and suggest that , by analogy , the gh-releasing effect of trh present in some disease states of the human may be due to an impairment of cns-ap connections . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
110,
112
]
} | {
"id": "C0032016",
"name": "ap",
"pos": [
354,
356
]
} |
beta-adrenergic agonists markedly stimulate camp production and pth release with an order of potency ( - ) isoproterenol greater than ( - ) epinephrine greater than greater than ( - ) norepinephrine , suggesting a beta2-type adrenergically mediated process . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
184,
198
]
} |
administration of taurine to a cat suffering from naturally occurring chronic ( about 3 years ) epilepsy caused disappearance of the clinical manifestation of the seizures as well as a marked improvement in the previously grossly abnormal eeg . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
96,
104
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
163,
171
]
} |
effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in `` '' simple '' '' febrile convulsions and `` '' epilepsy triggered by fever '' '' . | NA | {
"id": "C0009952",
"name": "febrile seizure",
"pos": [
58,
73
]
} | {
"id": "C0014544",
"name": "`` '' epile",
"pos": [
132,
143
]
} |
of 290 children with an initial febrile convulsion , 216 met livingston 's criteria for a `` '' simple '' '' febrile convulsion and 74 for `` '' epilepsy triggered by fever . '' '' | NA | {
"id": "C0009952",
"name": "febrile convulsion",
"pos": [
32,
50
]
} | {
"id": "C0014544",
"name": "`` '' epile",
"pos": [
139,
150
]
} |
the binding of the anionic phospholipids to the enzyme is manifested in a further enhancement of the fluorescence of a 1-anilinonaphthalene-8-sulphonate-enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
48,
54
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
153,
167
]
} |
rna sequences in ribonucleoprotein fragments of the complex formed from ribosomal 23-s rna and ribosomal protein l24 of escherichia coli . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
95,
104
]
} |
a soluble hydrophilic lipopolysaccharide , termed lipopolysaccharide ii , isolated from proteus mirabilis , strain d52 contained n-acetylglucosamine , glucose , galactose , ribitol phosphate and ethanolamine phosphate as constituents of the o-specific polysaccharide . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
22,
40
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
241,
266
]
} |
prostaglandin e2 and prostaglandin f2alpha were quantitatively determined in culture media from balb/c 3t3 fibroblasts and two virus-transformed derivatives of these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
107,
118
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
166,
171
]
} |
after preincubation of the apoa-i protein with lysolecithin , the enthalpy changes measured on subsequent binding of dimyristoyl lecithin were shifted towards more exothermal values compared to the curve for the native apoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
34,
41
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
219,
229
]
} |
antibodies against pig phosphorylase in pure form were isolated from rabbit antisera using insoluble immunoadsorbents of pig phosphorylase . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
76,
84
]
} |
complete inactivation of pig phosphorylase was accomplished by an antibody/enzyme molar ratio equal to 4 and autoantibody/enzyme molar ratio equal to 130 . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
66,
74
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
109,
121
]
} |
complete inactivation of rabbit phosphorylase was accomplished by an antibody/enzyme molar ratio equal to 250 and autoantibody/enzyme molar ratio equal to 160 . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
69,
77
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
114,
126
]
} |
kinetic experiments have shown that antibodies and autoantibodies act as noncompetitive inhibitors of both enzymes with respect to amp and glucose 1-phosphate but exhibit a mixed type of inhibition with respect to glycogen . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
36,
46
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
51,
65
]
} |
the quantitative precipitin and the ouchterlony agar gel reaction with several synthetic protein-peptide-conjugates , immunoaffinity chromatography of the antisera on sepharose- ( gly-gly-gly-gly-gly ) n and hapten inhibition studies with several synthetic peptides and peptide derivatives demonstrated that the antibodies were highly specific for oligoglycine peptides with c-terminal glycine . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
155,
163
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
312,
322
]
} |
it is concluded that d-glucose and other hexoses are transported by carrier-mediated diffusion across the plasma membrane of liver cells . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
23,
30
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
41,
48
]
} |
higher vapp values were obtained when the activity was measured as a function of the divalent cation-atp complex rather than as a function of either the divalent cation or atp because the free components competitively inhibited the activity in the presence of the cation-atp complex . | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
85,
100
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
264,
270
]
} |
there is a single-site interaction of [ methylene-14c ] thiamphenicol and [ methylene-14c ] chloramphenicol with run-off ribosomes with dissociation constants kd = 6.8 micronm and kd = 4.6 micronm respectively . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
56,
69
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
92,
107
]
} |
the lower-affinity bindings ( dissociation constants kd = 6.4 micronm and kd = 1.5 micronm for thiamphenicol and chloramphenicol respectively ) are due to the ribosomes bearing nascent peptides on the a-site . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
95,
108
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
113,
128
]
} |
the higher-affinity bindings ( dissociation constants kd = 2.3 micronm and kd = 1.5 micronm for thiamphenicol and chloramphenicol , respectively ) are due to the ribosomes bearing nascent peptides on the p-site . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
96,
109
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
114,
129
]
} |
therefore binding of nascent peptides to the a-site does not affect the affinities of thiamphenicol and chloramphenicol for the ribosome . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
86,
99
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
104,
119
]
} |
thiamphenicol and chloramphenicol are thus good inhibitors of peptide bond formation in ribosomes and polysomes . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
0,
13
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
18,
33
]
} |
cold paralysis never occurred spontaneously in this family and could not be provoked by immersion in ice water or by k+ load . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
101,
104
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
105,
110
]
} |
two cases with spinal cord compression due to paget 's disease ( osteodystrophia deformans ) are reported , which were treated with calcitonin ( salmon calcitonin ) during 12 and 24 months after decompressive laminectomy . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
132,
142
]
} | {
"id": "C0073994",
"name": "salmon calcitonin",
"pos": [
145,
162
]
} |
within six months of the introduction of the new antipsychotic drug clozapine in finalnd , 17 cases of neutropenia or agranulocytosis were recorded amongst about 3000 patients treated . | NA | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
103,
114
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
118,
133
]
} |
in contrast to commonly used rats , in which morphine induced dose-dependent changes in body temperature , the initial administration of morphine ( 5 , 10 , 20 , and 40 mg/kg , s.c. ) to rats of this particular strain produced a consistent and prominent hyperthermia . | NA | {
"id": "C0005904",
"name": "changes",
"pos": [
77,
84
]
} | {
"id": "C0015967",
"name": "hyperthermia",
"pos": [
254,
266
]
} |
i.v . infusions of norepinephrine ( ne ) , methylnorepinephrine ( mne ) , epinephrine ( e ) or phenylephrine ( phe ) in desipramine-treated dogs caused significant attenuation of nerve stimulation responses . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
19,
33
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
74,
85
]
} |
continuous differential analysis of norepinephrine and epinephrine output was quantified with an automated trihydroxyindole procedure . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
36,
50
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
55,
66
]
} |
the potentiation by crude kallikrein of the myotropic effect of angiotensin i is probably due to the conversion of decapeptide to octapeptide angiotensin ii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
64,
75
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
142,
156
]
} |
with its clinical use phencarol is effective in treating urticaria , quincke 's edema and allergic skin reactions . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
57,
66
]
} | {
"id": "C0002994",
"name": "quincke 's edema",
"pos": [
69,
85
]
} |
dopegit exerts an analogous action through formation of alpha-methyl-norepinephrine , which produces , like norepinephrine , an effect on the cerebral vessels . | NA | {
"id": "C0025805",
"name": "alpha-methyl-norepinephrine",
"pos": [
56,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
108,
122
]
} |
the activation of adenylate cyclase by 1-epinephrine and guanylylimidodiphosphate and its reversal by 1-epinephrine and gtp . | NA | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
57,
81
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
120,
123
]
} |
these proteins form a system including , along with albumins , globulins with electrophoretic mobility of alpha- and gamma-globulins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
52,
60
]
} |
arginine alone induced a rise in plasma growth hormone ( hgh ) and glucagon ( irg ) concentrations but did not affect the spontaneous diurnal decrease of plasma cortisol ; | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
40,
54
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
57,
60
]
} |
this last ivgtt revealed a glucose disappearance rate of 0.98 per cent per minute , and the slope of the regression line of serum-insulin response ( iri ) on blood glucose ( bg ) was markedly decreased to 0.005 micronu./ml . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
27,
34
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
158,
171
]
} |
sinus arrhythmia was also determined in order to evaluate its importance in altering the results of premature atrial stimulation : it should be pointed out that when arrhythmia was marked it was impossible to calculate sinoatrial conduction time . | NA | {
"id": "C0003813",
"name": "sinus arrhythmia",
"pos": [
0,
16
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
166,
176
]
} |
[ course of silicosis and the risk of silicotuberculosis morbidity in workers in the mining industry of kazakhstan ] . | NA | {
"id": "C0037116",
"name": "silicosis",
"pos": [
12,
21
]
} | {
"id": "C0037118",
"name": "silicotuberculosis",
"pos": [
38,
56
]
} |
the minimum migration index recorded with hbsag as antigen was significantly lower in those with detectable sensitisation to the lipoprotein and it is possible that this autoimmune reaction is also generated by the interaction of t cells with viral antigenic determinants on the liver cell surface . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
51,
58
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
249,
271
]
} |
the method is based upon extraction of urinary urobilinoids using a mixture of acetic acid and ether and followed by the extraction of the ethereal phase with ehrlich reagent and a solution of sodium acetate . | NA | {
"id": "C0000983",
"name": "acetic acid",
"pos": [
79,
90
]
} | {
"id": "C0142785",
"name": "sodium",
"pos": [
193,
199
]
} |
the impact of atmospheric electricity has been assessed in 1000 patients by daily urinalysis of serotonin , 5-hiaa , adrenaline , noradrenaline , histamine , thyroxine , 17-ks , 17-oh , na , k , creatinine and diureses . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
117,
127
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
130,
143
]
} |
some epilepsies demonstrate relations to the rhythm of sleep and wakefulness which become evident in the manifestation of seizures and epileptiform eeg activity at certain stages of vigilance . | NA | {
"id": "C0014544",
"name": "epilepsies",
"pos": [
5,
15
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
122,
130
]
} |
whereas heterologous antigen causes temporary immune reactions , autologous antigen induces chronically reactions with definite destruction of tissue . | NA | {
"id": "C0003333",
"name": "heterologous antigen",
"pos": [
8,
28
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
76,
83
]
} |
in addition to established gastrointestinal hormones -- secretin , cholecystokinin-pancreozymin ( cck-pz ) , gastrin , and glucagon -- -some 30 polypeptides with gastrointestinal actions can be listed . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
27,
52
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
56,
64
]
} |
in addition to established gastrointestinal hormones -- secretin , cholecystokinin-pancreozymin ( cck-pz ) , gastrin , and glucagon -- -some 30 polypeptides with gastrointestinal actions can be listed . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
27,
52
]
} | {
"id": "C0008328",
"name": "cholecystokinin-pancreozymin",
"pos": [
67,
95
]
} |
in addition to established gastrointestinal hormones -- secretin , cholecystokinin-pancreozymin ( cck-pz ) , gastrin , and glucagon -- -some 30 polypeptides with gastrointestinal actions can be listed . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
27,
52
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
109,
116
]
} |
vascular disease with decreased blood flow as its consequence can be found in a number of inflammatory diseases , in malign hypertensian , in collagen disease and in other more rare diseases as pseudoxanthoma elasticum or ehlers-danlos-syndrome . | NA | {
"id": "C0009326",
"name": "collagen disease",
"pos": [
142,
158
]
} | {
"id": "C0013720",
"name": "ehlers-danlos-syndrome",
"pos": [
222,
244
]
} |
these findings suggest that fibrosarcomas and malignant fibrous histiocytomas contain cells showing a spectrum of differentiation from fibrocytic to myogenic and that at the ultrastructural level the distinction between fibroblast and smooth muscle tumors may be blurred . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
86,
91
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
220,
230
]
} |
we report a rare disorder of the liver parenchyma causing portal hypertension , which can be difficult to diagnosis ante mortem , even with a full liver work-up including biopsy . | NA | {
"id": "C0023895",
"name": "disorder of the liver",
"pos": [
17,
38
]
} | {
"id": "C0020541",
"name": "portal",
"pos": [
58,
64
]
} |
at least some of these bodies were shown to be true micronucleoli by virtue of their ability to bind rrna during rna-dna hybridization in situ . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
101,
105
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
113,
116
]
} |
in contrast to control cells , hd fibroblasts plated more efficiently at the low seeding densities used . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
23,
28
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} |
the incidence of seizures among offspring was 2.4 % ( 4.2 % age-corrected ) in a narrow sense ( epilepsy ) and 9.1 % in a broad sense including febrile convulsions . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
17,
25
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
96,
104
]
} |
the incidence of seizures among offspring was 2.4 % ( 4.2 % age-corrected ) in a narrow sense ( epilepsy ) and 9.1 % in a broad sense including febrile convulsions . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
96,
104
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
144,
163
]
} |
using a microtiter bacterial agglutination test , we have estimated antibodies to corynebacterium parvum in `` '' normal '' '' human and `` '' normal '' '' and immune animal sera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
68,
78
]
} | {
"id": "C0020960",
"name": "and im",
"pos": [
156,
162
]
} |
the findings that pmn were more effective on a cell-to-cell basis , required less antiserum to sensitize for cytotoxicity , and destroyed ibr-gbk cells faster and more completely than other cell types could mean that pmn may be the cell type most importnat in causing early recovery from herpesvirus infections . | NA | {
"id": "C0021334",
"name": "ibr",
"pos": [
138,
141
]
} | {
"id": "C0019372",
"name": "herpesvirus infections",
"pos": [
288,
310
]
} |
the amino acids in casamino acids found to be necessary for growth and enterotoxin synthesis were proline , serine , aspartic acid , and alanine . | NA | {
"id": "C0815040",
"name": "amino",
"pos": [
4,
9
]
} | {
"id": "C0004015",
"name": "aspartic acid",
"pos": [
117,
130
]
} |
the evidence presented suggests that a subpopulation of b cells , which are distinct from those activated by lipopolysaccharide endotoxin , respond to tuberculin . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
109,
127
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
128,
137
]
} |
the envelope antigen , cell membrane antigen , and the soluble antigen prepared by density gradient centrifugation showed little reactivity with sera from varicella and hsv infections , but gave high antibody titers with sera from zoster infections , suggesting that a secondary v-z virus infection is required to produce an antibody response to these subunit antigens . | NA | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
169,
183
]
} | {
"id": "C0019360",
"name": "zoster",
"pos": [
231,
237
]
} |
the envelope antigen , cell membrane antigen , and the soluble antigen prepared by density gradient centrifugation showed little reactivity with sera from varicella and hsv infections , but gave high antibody titers with sera from zoster infections , suggesting that a secondary v-z virus infection is required to produce an antibody response to these subunit antigens . | NA | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
169,
183
]
} | {
"id": "C0008049",
"name": "v-z virus infection",
"pos": [
279,
298
]
} |
patients with varicella and zoster infections and the selected patients with hsv infections all showed significant cf antibody responses to the other v-z subunit antigens . | NA | {
"id": "C0008049",
"name": "varicella",
"pos": [
14,
23
]
} | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
77,
91
]
} |
patients with varicella and zoster infections and the selected patients with hsv infections all showed significant cf antibody responses to the other v-z subunit antigens . | NA | {
"id": "C0019360",
"name": "zoster",
"pos": [
28,
34
]
} | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
77,
91
]
} |
the hemagglutination-inhibiting ( hi ) and neutralizing antibody responses to smb , rha , and large envelope fragments ( 0.1 % doc ) were remarkably uniform , antibodies appearing at the same time , attaining similar hi titers ( lowest to envelope ) , and being of similar avidity early and late in the respone . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
43,
64
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
159,
169
]
} |
intraperitoneal administration of zinc ( znip ) as zinc chloride prior to or simultaneously with a lethal quantity of intraperitoneally administered salmonella typhimurium endotoxin significantly protected rats against toxin-induced mortality and hepatocellular damage . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
34,
38
]
} | {
"id": "C0078774",
"name": "zinc chloride",
"pos": [
51,
64
]
} |
the activity of the new cephamycin c derivatives cefoxitin against 102 clinical isolates of bacteroidaceae ( 95 bacteroides strains and 7 fusobacterium-sphaerophorus cultures ) was determined by tube dilution and standardized agar diffusion tests and compared to that of cephalothin . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
24,
34
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
49,
58
]
} |
a comparative study was conducted on the severity and course of postoperative urinary infections in prostatic adenoma patients with preoperative bacteriuria and patients without infection . | NA | {
"id": "C0042029",
"name": "of",
"pos": [
61,
63
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
145,
156
]
} |
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