text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in both groups urinary infections showed a similar tendency to resolve , whereas a significant increase of polyresistant bacterial strains was noted in patients with preoperative bacteriuria . | NA | {
"id": "C0042029",
"name": "urinary infections",
"pos": [
15,
33
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
179,
190
]
} |
an in vitro study of the susceptibility of 201 newly isolated strains of gramnegative bacteria to six aminoglycoside antibiotics ( kanamycin , amikacin , gentamicin , tobramycin , sisomicin and netilmicin ) was performed by the twofold dilution method in fluid medium . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
131,
140
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
143,
151
]
} |
an in vitro study of the susceptibility of 201 newly isolated strains of gramnegative bacteria to six aminoglycoside antibiotics ( kanamycin , amikacin , gentamicin , tobramycin , sisomicin and netilmicin ) was performed by the twofold dilution method in fluid medium . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
154,
164
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
180,
189
]
} |
an in vitro study of the susceptibility of 201 newly isolated strains of gramnegative bacteria to six aminoglycoside antibiotics ( kanamycin , amikacin , gentamicin , tobramycin , sisomicin and netilmicin ) was performed by the twofold dilution method in fluid medium . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
180,
189
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
194,
204
]
} |
netilmicin , the new derivative from sisomicin , compared favourably with the other drugs tested , but may , on theoretical grounds , offer the additional advantage of retained efficacy in the face of developing bacterial resistance . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
0,
10
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
37,
46
]
} |
when the amounts of whole antiserum , gamma-globulin fraction , or purified antibody were increased over the optimum in passive anaphylactic sensitization , the subsequent histamine release was reduced in spite of the fact that proportionately greater amounts of antigen were added to the system . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
26,
35
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
76,
84
]
} |
reaginic antibodies could be raised in both guinea pigs and rabbits by immunizing with pt- and hpt-protein conjugates but not by pt and hpt alone : these pca antibodies showed strong cross-reactivity and could be elicited equally well with either the pt- or hpt-protein derivatives . | NA | {
"id": "C0034761",
"name": "reaginic antibodies",
"pos": [
0,
19
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
158,
168
]
} |
complement , antilymphocyte globulin , antiencephalitogenic antigen serum , actinomycin d and mitomycin c inhibited the cytotoxicty against syngenic fibroblasts of spleen cells more than lymph node cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
149,
160
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
198,
203
]
} |
these observations suggest that enteric coated preparations and drugs which are inactivated by gastric fluid or irritate gastric mucosa should be administered only with ice water ( 4-6 degrees c ) , and stomach washings ( with charcoal ) in order to remove a poisoning agent should be performed with warm water ( 45 degrees c ) . | NA | {
"id": "C0020746",
"name": "ice water",
"pos": [
169,
178
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
305,
310
]
} |
hexosamine , galactose and total hexose were determined in four subfractions and sialic acid in all five . | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
13,
22
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
33,
39
]
} |
no hydrogen-addition free radicals on thymine were observed when the radiosensitized samples were annealed , in contrast to the pure dna samples . | NA | {
"id": "C0028128",
"name": "no",
"pos": [
0,
2
]
} | {
"id": "C0016693",
"name": "free radicals",
"pos": [
21,
34
]
} |
unsaturated lipids from membranes are subject to very efficient radiation-induced peroxidation , and the deleterious effects generally associated with lipid autoxidation could be initiated by ionizing radiation . | NA | {
"id": "C0025249",
"name": "lipids",
"pos": [
12,
18
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
151,
156
]
} |
tissue reactivity to carbon cloth , graphite cloth and vitreous carbon in the solid was studied in dogs . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
21,
27
]
} | {
"id": "C0302933",
"name": "graphite",
"pos": [
36,
44
]
} |
three of the ten viral rna segments did not co-run with type 1 rna , and the structural polypeptides of polyhedra had different molecular weights . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
17,
26
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
63,
66
]
} |
epimerase deficiency was restricted to circulating blood cells , but in liver biopsy specimens , in cultured skin fibroblasts and in activated lymphocytes epimerase was found to be normally active . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
57,
62
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} |
three young unrelated dogs were diagnosed as having the canine counterpart of ebstein 's anomaly , an eponymic term for a cardiac malformation in man . | NA | {
"id": "C0013481",
"name": "ebstein 's anomaly",
"pos": [
78,
96
]
} | {
"id": "C0018798",
"name": "cardiac malformation",
"pos": [
122,
142
]
} |
a sodium sulfite-precipitation test utilizing 3 concentrations of sodium sulfite to evaluate the immune status of neonatal calves allowed scoring of serum immunoglobulin concentrations as less than 5 mg/ml , 5 to 15 mg/ml , and greater than 15 mg/ml . | NA | {
"id": "C0038750",
"name": "sulfite",
"pos": [
9,
16
]
} | {
"id": "C0074771",
"name": "sodium sulfite",
"pos": [
66,
80
]
} |
the proposed method involves isopropanol pretreatment , followed by wet sieving and extraction of the light filth from 60 % ethanol with flotation oil . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
29,
40
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
124,
131
]
} |
the sample and standard solutions of heptachlor and heptachlor epoxide are placed in quartz cells and exposed to uv radiation in the dark . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
37,
47
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
52,
70
]
} |
concomitantly , the protein component ( 7 to 20 % ) was shown to contain the following amino acids : aspartic acid , threonine , serine glutamic acid , proline , glycine , alanine , valine , methionine , isoleucine , leucine , tyrosine , phenylalanine , lysine , histidine , and arginine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
87,
98
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
162,
169
]
} |
concomitantly , the protein component ( 7 to 20 % ) was shown to contain the following amino acids : aspartic acid , threonine , serine glutamic acid , proline , glycine , alanine , valine , methionine , isoleucine , leucine , tyrosine , phenylalanine , lysine , histidine , and arginine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
87,
98
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
244,
251
]
} |
the levels of purine nucleoside triphosphates ( adenosine 5 ' -triphosphate [ ctp ] , dctp ) and uridine nucleotides ( uridine 5 ' -triphosphate , deoxythymidine 5'-triphosphate ) . | NA | {
"id": "C0041921",
"name": "uridine nucleotides",
"pos": [
97,
116
]
} | {
"id": "C0042010",
"name": "uridine",
"pos": [
119,
126
]
} |
by use of a simple device for continuous co2 gassing of ureaplasma urealyticum cultures growing in a liquid medium , we have been able to separate some of the effects of urea , co2 , ammonia , and ph on growth . | NA | {
"id": "C0017110",
"name": "gassing",
"pos": [
45,
52
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
183,
190
]
} |
the defect in this enzyme leads to the absence of pseudouridines in the anticodon loop of several transfer ribonucleic acid species , as evidenced by the altered elution profile on reversed-phase chromatography and resistance to amino acid analogues . | NA | {
"id": "C0003284",
"name": "anticodon",
"pos": [
72,
81
]
} | {
"id": "C0035711",
"name": "transfer ribonucleic",
"pos": [
98,
118
]
} |
acid hexose phosphatase ( ec 3.1.2.2 ) possesses activity towards hexose phosphates as well as other sugar phosphates . | NA | {
"id": "C0019493",
"name": "hexose phosphates",
"pos": [
66,
83
]
} | {
"id": "C0038655",
"name": "sugar phosphates",
"pos": [
101,
117
]
} |
unlike acid protease from solid bran culture , which contains both carbohydrate-containing and the carbohydrate-free species , all of the four enzymes , e1 , e1a , e1b , and e2 , contained carbohydrate , ranging from 18.9 to 43 % and comprising three hexoses , glucose , galactose , and mannose . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
251,
258
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
271,
280
]
} |
unlike acid protease from solid bran culture , which contains both carbohydrate-containing and the carbohydrate-free species , all of the four enzymes , e1 , e1a , e1b , and e2 , contained carbohydrate , ranging from 18.9 to 43 % and comprising three hexoses , glucose , galactose , and mannose . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
251,
258
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
287,
294
]
} |
the carbohydrate portions were polysaccharide in nature and heterogeneous with respect to both molecular weight and sugar composition , and at least a part of the carbohydrate was present in the form of homopolysaccharides such as galactan and mannan . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
31,
45
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
244,
250
]
} |
besides catalyzing the formation of homocysteine from o-acetylhomoserine and sulfide , it also catalyzed the syntheses of o-alkylhomoserines corresponding to the alcohols added form o-acetylhomoserine and ethyl alcohol , n-propylalcohol , n-butyl alcohol , methyl alcohol , and n-pentyl alcohol , its activities with these alcohols decreasing in that order . | NA | {
"id": "C0001962",
"name": "ethyl alcohol",
"pos": [
205,
218
]
} | {
"id": "C0001963",
"name": "methyl alcohol",
"pos": [
257,
271
]
} |
the reaction was not stimulated by the addition of divalent cation and , in fact , was inhibited by the high concentrations of cation . | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
51,
66
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
127,
133
]
} |
crude extracts of escherichia coli selectively convert fd viral dna and not phix174 dna to duplex dna via a complex series of reactions one of which involves rna polymerase . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
58,
67
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} |
maximal synthesis requires the combined action of e. coli binding protein , dna elongation factor i , dna elongation factor ii preparations ( which are a mixture of dna z and dna elongation factor iii ) , dna polymerase iii , dna-dependent rna polymerase , mg2+ , datp , dgtp , dctp , dttp , and atp , gtp , ctp , and utp . | NA | {
"id": "C0043442",
"name": "dna z",
"pos": [
165,
170
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
226,
229
]
} |
in the presence of rna polymerase , rnase h , discriminatory factors alpha and beta , escherichia coli binding protein , dna elongation factor i , dna elongation factor ii preparation , dna polymerase iii , and atp , utp , gtp , ctp , datp , dttp , dgtp , and dctp , fd viral dna can be quantitatively converted to rfii containing a unique gap in the linear minus strand . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
270,
279
]
} |
thus , under discriminatory conditions , only fd viral dna leads to fd rna-dna complexes and no phix rna-dna hybrid is formed . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
49,
58
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
105,
108
]
} |
the proteins are identified as the viral envelope proteins by precipitation with anti-sindbis antiserum , by comparison with authentic virion glycoproteins on sodium dodecyl sulfate-poly-acrylamide gel electrophoresis , and by comparison of the glycopeptides of the membrane-associated glycoproteins with the glycopeptides from sindbis virions on gel filtration chromatography . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
142,
155
]
} | {
"id": "C0025248",
"name": "membrane",
"pos": [
266,
274
]
} |
a variety of other indole derivatives such as d-tryptophan , 5-hydroxyl-l-tryptophan , tryptamine , serotonin , melatonin , n-acetyl-l-tryptophan , n-acetyl-l-tryptophanamide , 3-indoleacetamide , 3-indolelactic acid , 3-indolepropionic acid , 3-indoleethanol , and skatole were also substrates . | NA | {
"id": "C0000578",
"name": "5-hydroxyl",
"pos": [
61,
71
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
159,
169
]
} |
the results showed that the affinities of the amino acids clustered into two groups , one including amino acids such as glycine , alanine , and alpha-aminoisobutyric acid and the other group included amino acids such as leucine and phenylalanine . | NA | {
"id": "C0017890",
"name": "amino",
"pos": [
46,
51
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
200,
211
]
} |
the results showed that the affinities of the amino acids clustered into two groups , one including amino acids such as glycine , alanine , and alpha-aminoisobutyric acid and the other group included amino acids such as leucine and phenylalanine . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
130,
137
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
200,
211
]
} |
l-alanine was used as a test amino acid for the a system and l-leucine for the l system . | NA | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
0,
9
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
29,
39
]
} |
the rate of transfer of amino acid from enzyme-bound aminoacyl adenylate to trna has been compared with the rate of esterification of free amino acid . | NA | {
"id": "C0035714",
"name": "aminoacyl",
"pos": [
53,
62
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
139,
149
]
} |
in this system , lipoproteins prepared from normocholesterolemic rat and human plasma , including low density lipoproteins , did not inhibit hepatocyte hmg-coa reductase activity whereas very low density lipoproteins and high density lipoproteins isolated from the same sources were stimulatory . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
17,
29
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
187,
216
]
} |
globin-specific sequences are found primarily as 9 s rna , but also are found with ribosomal rna , preferentially the 28 s moiety . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
53,
56
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
83,
96
]
} |
evidence is presented that a methyltransferase enzyme , previously shown to be necessary for chemotaxis and identified as the cher gene product , catalyzes the formation of a gamma-glutamyl methyl ester in one or more membrane proteins of salmonella typhimurium . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
131,
143
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
218,
235
]
} |
results from deae-cellulose column chromatography and polyacrylamide gel electrophoresis under nondenaturing conditions revealed only one enzyme activity in hela cell extracts which was capable of selectively hydrolyzing m7g ( 5 ' ) pppn to yield m7pg + ppn ( where n = 2'-o-methylated or unmethylated ribonucleosides or oligonucleotides of up to 8 to 10 nucleosides in length ) . | NA | {
"id": "C0035546",
"name": "ribonucleosides",
"pos": [
302,
317
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
355,
366
]
} |
anions such as so4 ( 2- ) , so3 ( 2- ) , chromate , and 2,4-dinitrophenolate , which stimulated atpase activity of f1 , also enhanced pi binding . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0008543",
"name": "chromate",
"pos": [
41,
49
]
} |
the enhancement is specific for amino acids transported by the a or alanine-preferring system ( aib , glycine , proline ) ; | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
32,
43
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
68,
75
]
} |
the enhancement is specific for amino acids transported by the a or alanine-preferring system ( aib , glycine , proline ) ; | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
32,
43
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
102,
109
]
} |
furthermore , loading cells with high concentrations of a single amino acid following a period of amino acid starvation fails to prevent the enhancement of aib transport , whereas incubation of the cells with the single amino acid for the entire duration of amino acid starvation prevents the enhancement ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
65,
75
]
} | {
"id": "C0815040",
"name": "amino acid",
"pos": [
258,
268
]
} |
rats fed a fat-free diet which increases the degree of saturation of fatty acids in the membrane lipids do produce microsomal membranes exhibiting a reversible lipid phase transition . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
88,
103
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
160,
165
]
} |
the incubation of dialyzed hemoglobin a with a number of phosphorylated glycolytic intermediates leads to the formation of covalent hemoglobin adducts that co-chromatograph with hemoglobin aib . | NA | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
27,
39
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
178,
188
]
} |
phosphorylated hexoses ( glucose-6-p , fructose-6-p , fructose-1,6-p2 ) and trioses ( glyceraldelyde-3-p , dihydroxyacetone-p ) containing a free aldehyde or ketone can glycosylate hemoglobin a nonenzymatically . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
15,
22
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
54,
62
]
} |
all of the hemoglobin a adducts were indistinguishable form hemoglobin aib by ion exchange chromatography and isoelectric focusing . | NA | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
11,
23
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
60,
70
]
} |
the hemoglobin a-glucose-6-p adduct and hemoglobin aib had a nab3h4-reducible linkage in the beta chain . | NA | {
"id": "C0019016",
"name": "hemoglobin",
"pos": [
4,
14
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
40,
50
]
} |
in this study , the ratio of the de novo synthesis of dtmp to hmdcmp derivatives was measured by determining the total thymine and 5-hydroxylxytosine ( hmcyt ) deoxyribonucleotides synthesized by the reductive pathways from [ 6-3h ] uracil including those in dna and any degradation products excreted into the medium . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
119,
126
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
233,
239
]
} |
at 0 degree , external k+ inhibits by interacting with the unphosphorylated enzyme to form an occluded enzyme-k complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
76,
82
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
103,
109
]
} |
mature 16 s rrna is derived from both 18 s and 17 s rna , and 17 s rna can be derived from 18 s . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
12,
16
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
67,
70
]
} |
the microspheres contain immobilized enzyme and can be slowly solubilized in water solutions , thereby releasing active a enzyme into the surrounding medium . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
25,
43
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
122,
128
]
} |
rat tail tendon tropocollagen rapidly caused the aggregation of blood platelets coincident with collagen multimerization . | NA | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
16,
29
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
96,
104
]
} |
these collagen derivatives varied in their polymerization properties , and the polymerization of tropocollagen derivatives was shown not necessarily to be a prerequisite for platelet aggregation . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
6,
14
]
} | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
97,
110
]
} |
tensile stresses at fracture were calculated to be about 5 x 10 ( 4 ) psi and 8 x 10 ( 3 ) psi in the lti carbon coating and the graphite substrate , respectively . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
106,
112
]
} | {
"id": "C0302933",
"name": "graphite",
"pos": [
129,
137
]
} |
in this method , the following advantages were observed : improvement of cardiac functions , reduction of mortality , prevention of ventricular aneurysm , prevention of the occurrence of arrhythmias and ventricular fibrillation , minimum reduction of the intracardiac capacity and no suture dehiscence resulting in cardiac rupture . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
187,
198
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
203,
227
]
} |
polysomes from the salivary glands of chironomus tentans were investigated to determine whether balbiani ring 75s rna is incorporated into polysomal structures , and thus probably acts as messenger rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
114,
117
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
188,
201
]
} |
in intermediate stages , there occurs a fourfold decrease in the level of rna synthesis and , while rrna continues to be formed , there is a disproportionate accumulation of the two major cytoplasmic rrna species in favor of the large ribosomal subunit rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
100,
104
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
253,
256
]
} |
both fractions contained significant amounts of a b-type cytochrome with several properties similar to those of cytochrome b5 from liver , as well as a rotenone-insensitive nadh- and nadph-cytochrome c reductase . | NA | {
"id": "C1256751",
"name": "b-type",
"pos": [
50,
56
]
} | {
"id": "C0010746",
"name": "cytochrome b5",
"pos": [
112,
125
]
} |
these data provide support for the hypothesis that the neurohypophysial peptides ( vasopressin and oxytocin ) and neurophysins are derived from the post-translational clevage of protein precursors synthesized in the son , and that the conversion process can occur in the neurosecretory granule during axonal transport . | NA | {
"id": "C0032017",
"name": "neurohypophysial peptides",
"pos": [
55,
80
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
99,
107
]
} |
the synthetic chemotactic factor formyl-methionyl-leucyl-phenylalanine ( fmlp ) was found to affect the fluxes of na+ , k+ , and ca2+ at concentrations as low as 10 ( -10 ) m . | NA | {
"id": "C0008013",
"name": "chemotactic factor",
"pos": [
14,
32
]
} | {
"id": "C0027229",
"name": "formyl-methionyl-leucyl-phenylalanine",
"pos": [
33,
70
]
} |
in the lamina , hyaluronic acid accounts for approximately 50 % of the labeled gag , chondroitin-4-sulfate is twice the chondroitin-6-sulfate , and there is a low proportion of chondroitin . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
79,
82
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
177,
188
]
} |
bromodeoxyuridine ( brdu ) incorporation into cellular dna has a differential effect on the cell-associated fluorescence of several dna-specific dyes . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
55,
58
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
134,
135
]
} |
we have examined the relative quantities of 18s and 28s rrna , 4s rna and poly ( a ) + mrna in the following cultured cells : the mouse fibroblast lines 3t3 and 3t6 in the resting ( contact inhibited ) and growing ( sparse ) states , 3t3 clones transformed with sv40 ( sv3t3 ) and with both sv40 and polyoma sv-py 3t3 ) , hamster lung fibrobalsts ( v79 ) , human cervical carcinoma cells ( hela ) , and human diploid fibroblasts at early and late passage . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
56,
60
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} |
in most cell lines the ratio of 4s rna to 18s rrna was between 0.8 and 1.2 , but in seescent fibroblasts , this ratio increased to greater than 1.7 . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
35,
38
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
46,
50
]
} |
senescent fibroblasts also contained much more total rna per unit of dna than the same cells at early passage or than 3t6 or 3t3 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
10,
21
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
the principle of polymer exclusion , by a surface hydrogel layer , is also consistent with observations on the inhibitory effects of adsorbed proteins-viz. , albumin , collagen , serum and cellular exudate , respectively-contrasted with the ready attachment of cells to a bare , optimally charged substratum , in this minimal in vitro system . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
142,
150
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
158,
165
]
} |
the method is simple and rapid and depends on the conversion of silica gel to potassium silicate , using potassium hydroxide , followed by acidification in such a way that the silicic acid is kept in solution . | NA | {
"id": "C2936385",
"name": "silica gel",
"pos": [
64,
74
]
} | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
176,
188
]
} |
the method is simple and rapid and depends on the conversion of silica gel to potassium silicate , using potassium hydroxide , followed by acidification in such a way that the silicic acid is kept in solution . | NA | {
"id": "C0086983",
"name": "silicate",
"pos": [
88,
96
]
} | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
176,
188
]
} |
fatty acid recovery from free fatty acid , phospholipid , glyceride and cholesterol ester zones is more than 90 % efficient . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
0,
10
]
} | {
"id": "C0015688",
"name": "fatty acid",
"pos": [
30,
40
]
} |
particularly convenient is the conversion of quinones into 2,4-dinitrophenylhydrazones , which makes the reliable identification of benzoquinones and naphthoquinones possible . | NA | {
"id": "C0034435",
"name": "quinones",
"pos": [
45,
53
]
} | {
"id": "C0079017",
"name": "benzoquinones",
"pos": [
132,
145
]
} |
the assay was used to determine the concentration of methadone ( i ) in whole blood samples from a normal volunteer following a single 9.4-mg oral dose of d-methadone hydrochloride , ( ii ) in whole blood , saliva and gastric juice from a methadone addict maintained on 90 mg of dimethadone hydrochloride per day , ( iii ) in mouse liver microsomes incubated with methadone , and ( iv ) in the perfusate of the isolated perfused rat liver . | NA | {
"id": "C0721688",
"name": "methadone hydrochloride",
"pos": [
157,
180
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
364,
373
]
} |
a quantitative gas-liquid chromatographic method for the determination of blood levels of ethosuximide , phenobarbitone , primidone and diphenylhydantoin is described . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
105,
119
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
122,
131
]
} |
subsequent flash alkylation with trimethylanilinium hydroxide allows the simultaneous determination of phenobarbitone , primidone , and diphenylhydantoin . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
103,
117
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
120,
129
]
} |
the paper describes a method for simultaneous thin-layer chromatographic separation of hydrocortisone , hydrocortisone acetate or hydrocortisone caproate alongside dibucaine hydrochloride , hexachlorophene and clemizole undecylate as well as clemizole hexachlorophenate in ointments and suppositories . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
87,
101
]
} | {
"id": "C0063077",
"name": "hydrocortisone acetate",
"pos": [
104,
126
]
} |
the response and elemental selectivity of the electrolytic conductivity detector ( e1cd ) to nitrogen- , chlorine- , and sulfur-containing compounds has been investigated as a function of chemical structure , furnace chemistry conditions ( i.e. , reaction gas , furnace temperature , catalyst , and post-furnace chemical abstractors ) , and solubilization-and-ionization processes ( electrolytic chemistry and electrolytic conductance ) . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
17,
26
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
93,
101
]
} |
the response and elemental selectivity of the electrolytic conductivity detector ( e1cd ) to nitrogen- , chlorine- , and sulfur-containing compounds has been investigated as a function of chemical structure , furnace chemistry conditions ( i.e. , reaction gas , furnace temperature , catalyst , and post-furnace chemical abstractors ) , and solubilization-and-ionization processes ( electrolytic chemistry and electrolytic conductance ) . | NA | {
"id": "C0008209",
"name": "chlorine",
"pos": [
105,
113
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
256,
259
]
} |
the former was suitable for chlorophylls , pheophytins and pheophorbides , and the latter for pheophorbides , chlorin , rhodin and their esters . | NA | {
"id": "C0008260",
"name": "chlorophylls",
"pos": [
28,
40
]
} | {
"id": "C0031512",
"name": "pheophytins",
"pos": [
43,
54
]
} |
although insulin and proinsulin also strongly inhibited msa binding , the properties of the growth peptide receptor differed from those of the human fibroblasts insulin receptor . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
9,
16
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
21,
31
]
} |
somatomedin a , nsila-s , msa , insulin and proinsulin all stimulated the incorporation of [ 3h ] thymidine into dna in human fibroblasts . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
32,
39
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
44,
54
]
} |
to determine whether cyclic somatostatin ( gh-rih ) interferes with glucose utilization and gluconeogenesis we studied levels of blood glucose ( bg ) , immunoreactive insulin ( iri ) , immunoreactive glucagon ( irg ) and of human growth hormone ( gh ) after iv glucose ( 330 mg/kg ) and iv arginine ( 0.5 g/kg ) in healthy subjects ( n=8 ) and in maturity onset diabetics ( n=8 ; fasting bg less than 200 mg/dl ) both in the presence and in the absence of gh-rih ( 500 microng/h iv ) . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
43,
45
]
} | {
"id": "C0169964",
"name": "human growth",
"pos": [
224,
236
]
} |
when sm rm was added to the 125i somatomedin c , some of the radioactivity eluted from gel filtration at ph 8.6 was converted to a molecular weight complex of about 43,000 . | NA | {
"id": "C0037657",
"name": "sm rm",
"pos": [
5,
10
]
} | {
"id": "C0021665",
"name": "somatomedin c",
"pos": [
33,
46
]
} |
concentrations of unconjugated testosterone , 17-hydroxyprogesterone ( 170hp ) and progesterone were measured by radioimmunoassay in amniotic fluid ( af ) specimens from normal pregnancies of 9-40 weeks gestation . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
46,
68
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
83,
95
]
} |
sheep blood agar , sheep blood agar with gentamicin sulfate ( gentamicin agar ) , and mouse inoculation with 4-h broth cultures were used . | NA | {
"id": "C0546866",
"name": "gentamicin sulfate",
"pos": [
41,
59
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
62,
72
]
} |
twenty percent of the strains apparently had partially lost their requirement for gaseous c02 and showed slight growth in air on medium without bicarbonate and slight to moderate growth in air on medium containing nahco3 . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
144,
155
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
214,
220
]
} |
medium conatining 0.1 % nahco3 , if incubated in a closed environment ( sealed jar ) , apperas to be equivalent to medium without bicarbonate incubated in ambient co2 in supporting the growth of some but not all strains of n. gonorrhoeae . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
24,
30
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
130,
141
]
} |
however , between the prolactin-treated and the control groups , there were no statistically significant differences in body weight and length , lung weight , the ratio of lung weight to body weight , dna , protein and , water content . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
105,
116
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
187,
198
]
} |
there is also intracellular accumulation of albumin in liver of uremic rats and a concomitant decrease in serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
44,
51
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
106,
119
]
} |
thirty-four recent clinical isolates of streptococcus faecalis were tested for sensitivity to amoxycillin , benzylpenicillin , streptomycin , kanamycin , gentamicin , tobramycin , and amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
142,
151
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
184,
192
]
} |
thus , eight ( 23 % ) strains showed a high level of resistance to streptomycin and kanamycin ( mic greater 5000 microng/ml ) but were sensitive to gentamicin , tobramycin , and amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
84,
93
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
178,
186
]
} |
in addition , two strains of strep . faecalis , isolated at different hospitals from patients who had received topical gentamicin therapy , were relatively resistant to gentamicin ( mic250 to 500 microng/ml ) and were less sensitive also to the other aminoglycosides . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
119,
129
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
251,
266
]
} |
an exception to this was the combination of amoxycillin plus amikacin which was not synergistic against kanamycin-resistant strains of strep . faecalis although these organisms were sensitive to amikacin in the growth inhibition tests . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
104,
113
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
195,
203
]
} |
the gentamicin-resistant strains showed variable responses to amoxycillin/aminoglycoside combinations in tests for bactericidal synergy and were generally less sensitive than typical strains of strep . faecalis . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
4,
14
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
74,
88
]
} |
intramuscularly administered methylprednisolone sodium phosphate ( medrol stabisol ) in single doses of 40 , 80 , or 160 mg ( methylprednisolone equivalents ) had a similar effect as the same doses of methylprednisolone sodium succinate ( solu-medrol ) with regard to eosinophil suppression , elevation of glucose , white blood count differential shifts ( lympholytic effect ) , urinary excretion of sodium and potassium , and localized ( pain ) and systemic side effects . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
29,
47
]
} | {
"id": "C0700546",
"name": "methylprednisolone sodium succinate",
"pos": [
201,
236
]
} |
the average plasma methylprednisolone concentration was approximately 20 % higher after the intramuscular administration of methylprednisolone sodium phosphate than after methylprednisolone sodium succinate . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
19,
37
]
} | {
"id": "C0700546",
"name": "methylprednisolone sodium succinate",
"pos": [
171,
206
]
} |
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