text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the third ncp was shown by amino acid composition to be the aspartate , serine-rich phosphoprotein , which occurs mostly in a soluble form in rat dentin . | NA | {
"id": "C0033684",
"name": "ncp",
"pos": [
10,
13
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
84,
98
]
} |
opinions have varied , and still do , on such matters as to whether or not the diagnosis of glaucoma is contingent upon a field defect , the existence of low tension glaucoma , the ramifications of ocular hypertension , what constitutes a glaucomatous appearance of the disc , field defects versus the appearance of the ... | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
92,
100
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
198,
217
]
} |
usually ovarian pregnancy finishes in rupture which occurs before the end of the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
16,
25
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
81,
96
]
} |
feulgen deoxyribonucleic acid cytophotometry of papanicolaou destained specimens revealed a differential loss in feulgen reactivity among human buccal and cervical smears , cultured embryonic lung fibroblasts and invasive cervical carcinoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
197,
208
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
241,
246
]
} |
other plant lectins ( wheat germ , leucoagglutinin , and pokeweed mitogen ) were also tested but con a was the only lectin found to inhibit antibody-gpc-mediated killing . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
6,
19
]
} | {
"id": "C0032350",
"name": "pokeweed",
"pos": [
57,
65
]
} |
other plant lectins ( wheat germ , leucoagglutinin , and pokeweed mitogen ) were also tested but con a was the only lectin found to inhibit antibody-gpc-mediated killing . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
6,
19
]
} | {
"id": "C0009630",
"name": "con a",
"pos": [
97,
102
]
} |
other plant lectins ( wheat germ , leucoagglutinin , and pokeweed mitogen ) were also tested but con a was the only lectin found to inhibit antibody-gpc-mediated killing . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
6,
19
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
116,
122
]
} |
cells treated with low concentrations of glutaraldehyde for a 10-sec interval were unable to incorporate 3h-leucine into tca precipitable protein , respond to h-2 allogeneic cells in mixed lymphocyte reactions ( mlr ) and cell-mediated lympholysis ( cml ) assays , or display capping of cell surface immunoglobulin ( ig ... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
163,
179
]
} |
it was found that the virgin b cell precursors of igm-producing cells are two types : cells bearing igm receptors only and those bearing both igm and igd receptors . | NA | {
"id": "C0018956",
"name": "cell precursors",
"pos": [
31,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
86,
91
]
} |
the arrangement of disulfide bonds joining secretory component ( sc ) to the alpha chains in secretory iga was studied by determining the molecular size of the principal fragments resulting from cnbr digestion of secretory dimeric fc fragments from iga ( fc ) 2alpha fragments ) . | NA | {
"id": "C0036538",
"name": "secretory component",
"pos": [
43,
62
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
93,
106
]
} |
the data indicate that sc is disulfide bonded to a single monomer subunit in secretory iga dimer . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
23,
25
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
77,
90
]
} |
chemical analysis provided evidence for greater amounts of lipid a and lipd a-associated protein ( lap ) per unit weight associated with lps ii . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
59,
66
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
137,
140
]
} |
induction of phenotypic lymphocyte differentiation in lps unresponsive mice by an lps-induced serum factor and by lipid a-associated protein . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
54,
57
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
114,
121
]
} |
phenotypic differentiation of c3h/hej lymphocytes can be induced with db-camp , lipid a-associated protein , and with a serum factor induced by lps in lps responder strains . | NA | {
"id": "C0023767",
"name": "lipid",
"pos": [
80,
85
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
151,
154
]
} |
the antisera against either enterotoxin were more effective in inhibiting the effects of homologous toxin than those of heterologous toxin , but cross-neutralization also occurred in both cases . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
28,
39
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
133,
138
]
} |
the major antigen of msp was demonstrated to have partial identity with reference mycobacterial antigen 6 , and evidence was obtained for separate shared and specific antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
10,
17
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
167,
176
]
} |
the major antigen of msp was demonstrated to have partial identity with reference mycobacterial antigen 6 , and evidence was obtained for separate shared and specific antigenic determinants . | NA | {
"id": "C0018593",
"name": "partial",
"pos": [
50,
57
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
167,
176
]
} |
the 50 % inhibitory concentrations ( ic50 ) of benzylpenicillin , streptomycin , sisomicin , gentamicin , tobramycin , kanamycin , amikacin , and butirosin were determined for 58 clinical isolates of streptococcus faecalis , 28 of which were recovered from cultures of blood samples from patients with endocarditis . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
81,
90
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
93,
103
]
} |
the 50 % inhibitory concentrations ( ic50 ) of benzylpenicillin , streptomycin , sisomicin , gentamicin , tobramycin , kanamycin , amikacin , and butirosin were determined for 58 clinical isolates of streptococcus faecalis , 28 of which were recovered from cultures of blood samples from patients with endocarditis . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
119,
128
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
131,
139
]
} |
the bactericidal effects of combinations of penicillin and aminoglycosides were studied in 20 strains of s. faecalis that represented different levels of resistance to streptomycin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
59,
74
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
168,
180
]
} |
combinations of penicillin and sisomicin , gentamicin , or tobramycin were effective even against strains that were highly resistant to streptomycin and kanamycin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
31,
40
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
43,
53
]
} |
the intrarenal distribution and excretion of 125i-rat fibrinogen was examined to determine whether there was increased filtration of bibrinogen or fibrin degradation products ( fdp ) or lysis of intraglomerular fibrin . | NA | {
"id": "C0163275",
"name": "fibrin",
"pos": [
54,
60
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
211,
217
]
} |
the inactivation of erythrocytic gssg-r results in decreased levels of reduced glutathione ( gsh ) , marked gsh instability and disturbed hydrogen peroxide removal with a positibe ascorbate cyanide test and leads to increased susceptibility to oxidative hemolysis , particularly in glucose-6-phosphate dehydrogenase ( g-... | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
33,
37
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
108,
111
]
} |
the results are consistent with several recent observations that saa is normal acute phase reactant , and hence the ria for saa has no prognostic or diagnostic significance for secondary amyloidosis . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
79,
90
]
} | {
"id": "C0002723",
"name": "saa",
"pos": [
124,
127
]
} |
the antisera obtained by the above method are devoid or almost devoid of cross-reactive antibodies . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
4,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
88,
98
]
} |
the concentrations of dehydroepiandrosterone ( dhea ) and 17alpha-hydroxypregnenolone ( delta5 intermediates ) , androstenedione and testosterone were higher in non-ovulatory follicles , whereas large follicles usually contained high levels of progesterone , 17alpha-hydroxyprogesterone , pregnenolone and oestradiol-17b... | NA | {
"id": "C0376260",
"name": "17alpha-hydroxypregnenolone",
"pos": [
58,
85
]
} | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
289,
301
]
} |
this finding that 5alpha-androstane-3beta,17beta-diol is a major product of testosterone metabolism in vitro by human skin containing sebaceous glands , supports the possibility , previously suggested by studies in the rat , that this steroid can stimulate sebum secretion . | NA | {
"id": "C0002854",
"name": "androstane",
"pos": [
25,
35
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
235,
242
]
} |
effects of anterior hypothalamic implantation of gonadal steroids on serum and pituitary gonadotrophins ( follicle-stimulating hormone and luteinizing hormone ) in the castrated male rat . | NA | {
"id": "C0018066",
"name": "pituitary gonadotrophins",
"pos": [
79,
103
]
} | {
"id": "C0733758",
"name": "follicle-stimulating hormone",
"pos": [
106,
134
]
} |
effects of anterior hypothalamic implantation of gonadal steroids on serum and pituitary gonadotrophins ( follicle-stimulating hormone and luteinizing hormone ) in the castrated male rat . | NA | {
"id": "C0018066",
"name": "pituitary gonadotrophins",
"pos": [
79,
103
]
} | {
"id": "C0023607",
"name": "luteinizing hormone",
"pos": [
139,
158
]
} |
firstly , the icms did not bind a fluorescein-conjugated antibody directed against rabbit igg , indicating the absence of cells exposed to the rabbit antiserum during the immunosurgical procedure . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
57,
65
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
150,
159
]
} |
this dna has a similar density to mammalian cellular dna , is 4 -- 6s insize , and probably represents a mixture of single-stranded dna ( ssdna ) and double-stranded dna ( dsdna ) or dsdna with some single-stranded regions . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
150,
169
]
} |
purified populations of igm- , igd- , and igg-bearing cells were prepared by immunofluorescent staining with isotype-specific reagents , and sorting on the fluorescence activated cell sorter . | NA | {
"id": "C0020843",
"name": "igd",
"pos": [
31,
34
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
109,
116
]
} |
pigment cell migration was used as an indicator to study the effects of the plant lectin , concanavalin a ( con a ) , on epidermal cell closure of skin wounds . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
76,
88
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
91,
105
]
} |
the products of enzyme action include various oligosaccharide and polysaccharide fractions which have been separated by gel filtration and characterized , giving new information on the fine structure of the glucan . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
46,
61
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
66,
80
]
} |
antisera produced to freshly prepared virus antigen grown in brains of baby mice distinguished svdv from the serologically related coxsackie b-5 virus but did not distinguish the individual s particle antigens . | NA | {
"id": "C0003342",
"name": "virus antigen",
"pos": [
38,
51
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
201,
209
]
} |
four classes of virus dna molecules were observed : ( a ) mature linear dna molecules , 52-4 +/- 3-3 micronm in length , ( b ) dna intermediates , ( c ) virus dna molecules having one or more single-stranded filaments attached to them and ( d ) molecules with collapsed regions or with branches . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
22,
35
]
} | {
"id": "C0919262",
"name": "b",
"pos": [
286,
287
]
} |
however , very large doses of apomorphine cause a haloperidol-resistant inhibition of tyrosine , and probably also tryptophan , hydroxylation , which may be due to a direct inhibition of the aromatic amino acid hydroxylase involved . | NA | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
86,
94
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
191,
210
]
} |
however , very large doses of apomorphine cause a haloperidol-resistant inhibition of tyrosine , and probably also tryptophan , hydroxylation , which may be due to a direct inhibition of the aromatic amino acid hydroxylase involved . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
115,
125
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
191,
210
]
} |
differentiation in brain and liver dopa/5htp decarboxylase activity after l-dopa administration with or without pyridoxine in cats . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
35,
39
]
} | {
"id": "C0023570",
"name": "dopa",
"pos": [
76,
80
]
} |
numerous investigators , using tritiated thymidine to label mononuclear blood cells , have proposed a hematogenous origin for some of the reactive cells responding to injury in the cns . | NA | {
"id": "C1321301",
"name": "mononuclear blood",
"pos": [
60,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
147,
152
]
} |
all had been pretreated with l-dopa for 5 -- 8 years and taking dopa di for a minimum of 3 years . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
29,
35
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
64,
68
]
} |
safflower oil , a highly unsaturated fat , promoted a higher rate of cholesterol absorption than butter , regardless of the level of dietary cholesterol . | NA | {
"id": "C0036048",
"name": "safflower oil",
"pos": [
0,
13
]
} | {
"id": "C0012172",
"name": "unsaturated fat",
"pos": [
25,
40
]
} |
growth rate , plasma amino acid , and alpha-keto acid concentrations and activities of the branched-chain amino acid degradative enzymes of rats were measured . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
21,
31
]
} | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
91,
116
]
} |
the decreases in plasma isoleucine , valine , alpha-keto-beta-methylvaleric acid and alpha-keto isovaleric acid were not caused by increased degradation of these metabolites to carbon dioxide as branched-chain amino acid oxidation rates in vivo were unchanged by leucine loading and the degradative enzymes were unchange... | NA | {
"id": "C0042285",
"name": "valine",
"pos": [
37,
43
]
} | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
195,
220
]
} |
the decreases in plasma isoleucine , valine , alpha-keto-beta-methylvaleric acid and alpha-keto isovaleric acid were not caused by increased degradation of these metabolites to carbon dioxide as branched-chain amino acid oxidation rates in vivo were unchanged by leucine loading and the degradative enzymes were unchange... | NA | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
195,
220
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
263,
270
]
} |
a total of 31 workers employed in hot work in small-scale foundries , 13 gardeners engaged at light jobs under the sun and 16 sedentary persons were selected after medical screening for a study of the levels of serum enzymes [ glutamic oxalacetic transaminase ( got ) , glutamic pyruvic transaminase ( gpt ) , lactic deh... | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
247,
259
]
} | {
"id": "C0001899",
"name": "glutamic pyruvic transaminase",
"pos": [
270,
299
]
} |
three children with severe hypernatremia presented with profound generalized weakness and biochemical evidence of rhabdomyolysis and myoglobinuria . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
114,
128
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
133,
146
]
} |
the dose was calculated to correct the deficit of base in a bicarbonate space of 400 ml/kg and was given at a rate of 0.3 mm nahco3/kg/minute . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
60,
71
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
125,
131
]
} |
serial serum theophylline levels and half-life determinations for two patients suggest that , although serum half-lives ( 8.5 hours and 9.0 hours ) may be slightly longer than average , drug disappearance followed first order kinetics even at extremely high erum theophylline levels . | NA | {
"id": "C0018517",
"name": "half-lives",
"pos": [
109,
119
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
226,
234
]
} |
using concanavalin a labeled with tritium and fluorescein isothiocyanate we studied the binding properties of this plant lectin to adult paired schistosomes . | NA | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
6,
20
]
} | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
115,
127
]
} |
this nonimmunologic fixation resulted in the depletion of hemolytically active complement from fresh guinea pig serum , the conversion of human c3 to an electrophoretically faster species and the genration of smooth muscle contracting substances , analogous to anaphylatoxins , in normal rat serum in vitro . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
79,
89
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
261,
275
]
} |
use of propionate by these worms , for whatever metabolic purpose , would result in depriving the ruminant host of some of its necessary glucogenic precursors , and could account for a specific pathogenic mechanism attendant to heavy infections with this parasite . | NA | {
"id": "C0018889",
"name": "worms",
"pos": [
27,
32
]
} | {
"id": "C0030499",
"name": "infections",
"pos": [
234,
244
]
} |
[ the reaction of heteroaromatic n-oxide with acid chloride and cyanide . ii . on the reaction of 2,4-disubstituted quinoline 1-oxide with benzoyl chloride and potassium cyanide ( author 's transl ) ] . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
64,
71
]
} | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
160,
177
]
} |
the monovalent cations , nat , kt , and cst inhibited histamine binding to peptide h , with the extent of inhibition dependent on cation concentration . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
4,
22
]
} | {
"id": "C0033727",
"name": "h",
"pos": [
108,
109
]
} |
the monovalent cations , nat , kt , and cst inhibited histamine binding to peptide h , with the extent of inhibition dependent on cation concentration . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
4,
22
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
130,
136
]
} |
the influence of various test meals and fluid volume on the relative bioavailability of ampicillin and amoxicillin was studied in healthy human subjects . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
88,
98
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
103,
114
]
} |
serum amoxicillin levels were somewhat , but not always , significantly higher than those of ampicillin from equivalent oral doses . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
6,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
93,
103
]
} |
two other catechols , epinephrine and norepinephrine , were also blocked more effectively by bol and uml than by mersaly . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
22,
33
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} |
plasma concentrations of epinephrine and norepinephrine were no different in blood samples obtained from sprague-dawley rats 15 and 60 days of age . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} |
we conclude that both increases and decreases in central dopaminergic activity can reduce feeding and propose that some intermediate rate of dopamine release provides an optimal level of neuronal activity for feeding by the hungry animal . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
57,
69
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
141,
149
]
} |
histamine increased vascular permeability , as measured by accumulation of [ 131i ] human serum albumin in the tissue , during infusions at 1 x 10 ( -8 ) mol/kg min but no albumin accumulation could be detected at lower infusion rates . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
84,
103
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
172,
179
]
} |
the use of lanthanum to estimate the numbers of extracellular cation-exchanging sites in the guinea-pig 's taenia coli , and its effects on transmembrane monovalent ion movements . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
62,
68
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
165,
168
]
} |
the failure of metiamide to inhibit acid secretion induced by dibutyryl cyclic amp suggests that cyclic amp might regulate gastric acid secretion at a site beyond the histamine h2-receptor activation . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
62,
82
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
97,
107
]
} |
although postmenopausal women taking estrogen may have uterine bleeding related to the hormone , such bleeding can not be assumed to be due to the therapy and always requires evaluation . | NA | {
"id": "C0042134",
"name": "uterine bleeding",
"pos": [
55,
71
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
102,
110
]
} |
in general , the binding of the leucomycins and the leucomycin derivatives to ribosomes correlated with their antimicrobial activity . | NA | {
"id": "C0023410",
"name": "leucomycins",
"pos": [
32,
43
]
} | {
"id": "C0022723",
"name": "leucomycin",
"pos": [
52,
62
]
} |
dimetridazole , a nitroimidazole drug reported to act only on obligately anaerobic micro-organisms , is widely used for the prevention and treatment of swine dysentery . | NA | {
"id": "C0012444",
"name": "dimetridazole",
"pos": [
0,
13
]
} | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
18,
32
]
} |
the poly ( a ) ( + ) -rna fraction had no detectable rrna or trna and gave a heterogeneous pattern , typical of mrna , in the sucrose gradients . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
22,
25
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
53,
57
]
} |
the poly ( a ) ( + ) -rna fraction had no detectable rrna or trna and gave a heterogeneous pattern , typical of mrna , in the sucrose gradients . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
22,
25
]
} | {
"id": "C0035696",
"name": "mrna",
"pos": [
112,
116
]
} |
selective induction of intestinal tumors in rats by methyl ( acetoxymethyl ) nitrosamine , an ester of the presumed reactive metabolite of dimethylnitrosamine . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
77,
88
]
} | {
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
139,
158
]
} |
methyl ( acetoxymethyl ) nitrosamine ( dmn-oac ) was synthesized and tested for toxicity and carcinogenicity in rats to test the hypothesis that alpha-hydroxylation is required for metabolic activation of dimethylnitrosamine ( dmn ) to a reactive , proximate carcinogen . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
25,
36
]
} | {
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
205,
224
]
} |
ebna binds to both double-stranded and single-stranded calf thymus dna , showing a higher affinity to double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
39,
54
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
102,
121
]
} |
furthermore , we find that the low-molecular-weight nucleic acid fraction extracted from purified rsv virions contains dna that can hybridize to rsv 70s rna and that the virion dna in such hybrids can function as a primer for an extensive in vitro reverse transcription . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
52,
64
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
177,
180
]
} |
a complex form of bacteriophage t7 dna , containing up to several hundred phage equivalents of dna , arises during replication of t7 . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
95,
98
]
} |
new methods to localize the source of bacteriuria were evaluated in monkeys with experimental urinary tract infection . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
38,
49
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
94,
117
]
} |
the involvements of adrenergic mechanism in the central pressor effect of angiotensin ii were studied through observation of blood pressure changes following injection of angiotensin ii , phentolamine and propranolol into the rabbit lateral ventricle of rabbit brain . ( 1 ) intraventricular administration of phentolami... | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
74,
88
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
374,
385
]
} |
two of these strains were resistant to erythromycin , josamycin , oleandomycin , spiarmycin , mydecamycin , lincomycin , clindamycin and tetracycline , but one was resistant to josamycin , spiramycin , mydecamycin and chloramphenicol . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
108,
118
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
121,
132
]
} |
these observations imply that immunocompetent cells causing gvhr can be separated from hemopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0018956",
"name": "hemopoietic",
"pos": [
87,
98
]
} |
major complications encountered were laceration and bleeding ( 1 case ) , hematoma formation and bleeding ( 2 cases ) , and malpositioning of the catheter resulting in mild brain damage ( 1 case ) . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
74,
82
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
97,
105
]
} |
with intravenous injection , the responses to bradykinin and kallidin were lower , and to angiotensin i -- higher , than with their intra-aortic administration . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
46,
56
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
61,
69
]
} |
the administration of all the preparations against the background of 2,3-dimercaptopropanol ( unithiol ) resulted in levelling of the responses irrespective of the mode of administration . | NA | {
"id": "C0012383",
"name": "dimercaptopropanol",
"pos": [
73,
91
]
} | {
"id": "C0041738",
"name": "unithiol",
"pos": [
94,
102
]
} |
along with the progress of atherosclerosis , the infiltration of proteins , lipoproteins and lipids is increasing . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
76,
88
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
93,
99
]
} |
in vitro experiments employing the polarographic technique of in-rush currents have demonstrated that adrenalin and noradrenaline in concentrations approaching those found in blood of myocardial infarction patients during the early days of the disease inhibit the tissue respiration of the cardiac muscle by 10 -- 50 % . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
102,
111
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
116,
129
]
} |
a continuous ( for 24 hours ) ecg recording on a magnetic tape with its subsequent decodification on a special analyser was performed in 31 patients with acute myocardial infarction during the 1st day of the onset of the disease in order to reveal an accelerated idioventricular rhythm and ventricular tachycardia . | NA | {
"id": "C0078888",
"name": "accelerated idioventricular rhythm",
"pos": [
251,
285
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
290,
313
]
} |
several diseases are analysed mainly with respect to indications or contraindications for laser coagulation : prophylactic treatment of retinal detachment , dry senile maculopathies , exsudative maculopathies ( central serous retinopathy , retinal pigment epithelial detachment , fuchs myopic maculopathy , exudative sen... | NA | {
"id": "C0730328",
"name": "central serous retinopathy",
"pos": [
211,
237
]
} | {
"id": "C0035309",
"name": "retinopathy",
"pos": [
412,
423
]
} |
the relationship of concentrations from plasma to cerebrospinal fluid was 2 for beta-methyldigoxin and 8 for digoxin . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
80,
98
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
109,
116
]
} |
[ biochemical characterization of a new variant of glucose-6-phosphate dehydrogenase ( g-6-pd ) deficiency with favism : g-6-pd bielefeld ( author 's transl ) ] . | NA | {
"id": "C2939465",
"name": "of",
"pos": [
31,
33
]
} | {
"id": "C0015702",
"name": "favism",
"pos": [
112,
118
]
} |
[ determination of serotonin , tryptophan , 5-hydroxytryptophan , 5-hydroxyindoleacetic acid , histamine and histidine in one test of biological material ] . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
31,
41
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
44,
63
]
} |
this steroid exerted no effect on sodium metabolism in adrenalectomized rats or in the toad bladder assay , but it markedly enhanced activity of subthreshold doses of aldosterone in reducing sodium excretion in urine of adrenal-ectomized rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
41,
51
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
198,
207
]
} |
serum-25-hydroxyvitamin-d3 ( 25-ohd3 ) concentrations in 78 % of the 124 asian boys resembled those found in rickets and osteomalacia . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
109,
116
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
121,
133
]
} |
in 20 amniotic-fluid samples taken in the second trimester from pregnancies in which the fetus had a neural-tube defect , the proportion of the total viable cell which adhered to glass surfaces after 20 hours in culture ranged from 9 to 100 % . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
42,
58
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
64,
75
]
} |
peptides with opiate-like actions ( endorphins , enkephalins ) are known to be normal constituents of the brain and now enkephalin-like immunoreactivity has been shown in the gut . | NA | {
"id": "C0205753",
"name": "peptides",
"pos": [
0,
8
]
} | {
"id": "C0014242",
"name": "endorphins",
"pos": [
36,
46
]
} |
peptides with opiate-like actions ( endorphins , enkephalins ) are known to be normal constituents of the brain and now enkephalin-like immunoreactivity has been shown in the gut . | NA | {
"id": "C0205753",
"name": "peptides",
"pos": [
0,
8
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
120,
130
]
} |
icab-positive diabetics on o.h.a . had a high prevalence of a personal history of organ-specific autoimmune disease , thyrogastric antibodies , a family history of insulin-dependent diabetes and possibly of hla-b8 comparable to that in insulin-dependent diabetes and higher than that expected in a control population or ... | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
97,
115
]
} | {
"id": "C0011854",
"name": "insulin-dependent diabetes",
"pos": [
236,
262
]
} |
while palmitic and stearic acids were the predominant normal fatty acids throughout intrauterine life , long chain fatty acids , like lignoceric and nervonic acids , which were low at early gestational ages , rapidly accumulated at term . | NA | {
"id": "C0038230",
"name": "stearic acids",
"pos": [
19,
32
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
115,
126
]
} |
obesity ( greater than 25 % fat ) , elevated triglycerides ( greater than 100 mg % ) and the presence of type iv hyperlipoproteinemia appear to be the more predominant risk factors . | NA | {
"id": "C0020557",
"name": "elevated",
"pos": [
36,
44
]
} | {
"id": "C0020480",
"name": "type iv",
"pos": [
105,
112
]
} |
using excess hepatic iron as a marker for inheritance of hemochromatosis , results of liver biopsies on 31 family members suggest an auto-somal dominant mode of inheritance with incomplete expressivity . | NA | {
"id": "C0282193",
"name": "excess",
"pos": [
6,
12
]
} | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
57,
72
]
} |
best results were obtained with the administration of gentamicin , the newer aminoglycoside antibiotic sisomicin , tobramycin and amikacin , or the combination of gentamicin with carbenicillin or with cephalosporins . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
103,
112
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
163,
173
]
} |
introduction into the medium of such inductors as cholesterol , cortisone , cortisone acetate , and acetate of substance s had different effect on growth of the cells and their cholesterol decomposing ability . | NA | {
"id": "C0010137",
"name": "cortisone",
"pos": [
64,
73
]
} | {
"id": "C0056391",
"name": "cortisone acetate",
"pos": [
76,
93
]
} |
the amino acid composition of the peptide moiety of s-pnpc was rather similar in the case of different algae , and was characterized by the prevailence of acid amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0815040",
"name": "acid amino acids",
"pos": [
155,
171
]
} |
whereas both iron drugs proved equally compatible when administered in therapeutical doses , it was again confirmed that the enteral bioavailability of the ferrous iron sulfate is superior to that of the ferric iron complex preparation . | NA | {
"id": "C0302583",
"name": "iron drugs",
"pos": [
13,
23
]
} | {
"id": "C0060282",
"name": "of",
"pos": [
197,
199
]
} |
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