text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
occurrence of the hepatitis b surface antigen in the paraffin-embedded sections of needle-hepatic-biopsy taken for diagnostic purpose from 138 patients ( 108 adults and 30 children ) and from 52 simptomless hepatitis b antigen positive donors was investigated ( modified orcein dye , `` '' ground glass '' '' hepatocytes ) . | NA | {
"id": "C0019168",
"name": "hepatitis b surface antigen",
"pos": [
18,
45
]
} | {
"id": "C0019165",
"name": "hepatitis b antigen",
"pos": [
207,
226
]
} |
with persistent bad oral hygiene , a gingivitis may develop into a progressive periodontitis with deepened gingival pockets . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
37,
47
]
} | {
"id": "C0017571",
"name": "gingival pockets",
"pos": [
107,
123
]
} |
rates of semiconservative dna synthesis have been investigated in asynchronous xeroderma pigmentosum ( xp ) , xp variant , and normal human skin fibroblasts using the technique of cellular autoradiography . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
145,
156
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
180,
188
]
} |
therefore , we sought to correlate clinical susceptibility to two herpesvirus ( simplex and zoster ) infections with specific cellular immunity , assessed by the transformation and interferon responses of peripheral blood mononuclear cells to heat-inactivated antigens . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
126,
134
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
205,
239
]
} |
condtions for optimum pullulan production are fast undisturbed growth , mediated by fast utilizable simple sugars like glucose followed by a substantial decreased growth rate in which production occurs , mediated by a sufficient supply of nutrite substances and a slow utilizable carbohydrate like starch . | NA | {
"id": "C0026492",
"name": "simple",
"pos": [
100,
106
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
280,
292
]
} |
independent of the dietary proteins the amino acid composition of both fractions ( s2 and the peptides from u2 ) is similar in relation to protein-free feeding ; | NA | {
"id": "C0012177",
"name": "dietary proteins",
"pos": [
19,
35
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} |
the butyrophenones , haloperidol and spiroperidol , already at low concentrations ( 0.1 - 1 micronm ) increased basal tritium efflux in a dose-dependent manner . | NA | {
"id": "C0006525",
"name": "butyrophenones",
"pos": [
4,
18
]
} | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
37,
49
]
} |
by the simultaneous use of sensitive and specific radioimmunoassays for prostaglandins e1 and e2 the prostaglandin e-like substance released by the rabbit splenic capsular strips was found to resemble serologically much more the dienoic prostaglandin e2 than prostaglandin e1 . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
101,
116
]
} | {
"id": "C0012472",
"name": "prostaglandin e2",
"pos": [
237,
253
]
} |
there was a marked increase in clearance of the majority of amino acids when glomerular filtration rate ( gfr ) fell below 30 ml/min/1.73 m2 : the exceptions were the basic amino acids and cystine which did not change . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
60,
71
]
} | {
"id": "C0301714",
"name": "basic amino",
"pos": [
167,
178
]
} |
in cases of the old hemorrhage , besides the decreased density area of the hematoma , such findings were obtained as cerebral atrophy , ventricular dilatation and porencephalic change . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
20,
30
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
75,
83
]
} |
phenobarbital , phenytoin , carbamazepine , primidone , and ethosuximide were measured in saliva and plasma obtained simultaneoulsy from 115 patients . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
0,
13
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
44,
53
]
} |
forty-five children with major motor or psychomotor seizure disorders were treated with carbamazepine in place of sedative anticonvulsants ( phenobarbital , primidone ) because of chronic behavioral difficulties . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
141,
154
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
157,
166
]
} |
the concentration of betamethasone has been measured in maternal peripheral plasma , umbilical cord artery and vein , and amniotic fluid following maternal administration of betamethasone phosphate and betamethasone acetate on 3 consecutive days . | NA | {
"id": "C0005308",
"name": "betamethasone",
"pos": [
21,
34
]
} | {
"id": "C0700603",
"name": "betamethasone phosphate",
"pos": [
174,
197
]
} |
the concentration of betamethasone has been measured in maternal peripheral plasma , umbilical cord artery and vein , and amniotic fluid following maternal administration of betamethasone phosphate and betamethasone acetate on 3 consecutive days . | NA | {
"id": "C0005308",
"name": "betamethasone",
"pos": [
21,
34
]
} | {
"id": "C0005310",
"name": "betamethasone acetate",
"pos": [
202,
223
]
} |
of the infectious lesions in and around the mouth , gingival infection in more advanced stages of periodontal disease seems to be the most likely candidate for acting as a focus of infection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
61,
70
]
} | {
"id": "C0016397",
"name": "focus",
"pos": [
172,
177
]
} |
in the initial descriptions of the elfin-facies-syndrome by williams and beuren , supravalvular aortic stenosis was considered to be a constant feature of the syndrome , combined with retardation of mental and physical development , dentition anomalies and the peculiar face . | NA | {
"id": "C0175702",
"name": "elfin-facies-syndrome",
"pos": [
35,
56
]
} | {
"id": "C0003499",
"name": "supravalvular aortic stenosis",
"pos": [
82,
111
]
} |
in vitro , the drug pentosan-poly-sulfoester ( pps ) changes the electrophoretic migration of different proteins from the complement and properdin systems , such as native c3 ( beta 1c globulin ) , c3c ( beta-1a globulin ) , c3d ( alpha-2d globulin ) , c1s inactivator ( clsina ) , clq and properdin factor b ( b ) . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
122,
132
]
} | {
"id": "C0033453",
"name": "properdin factor b",
"pos": [
290,
308
]
} |
in vitro , the drug pentosan-poly-sulfoester ( pps ) changes the electrophoretic migration of different proteins from the complement and properdin systems , such as native c3 ( beta 1c globulin ) , c3c ( beta-1a globulin ) , c3d ( alpha-2d globulin ) , c1s inactivator ( clsina ) , clq and properdin factor b ( b ) . | NA | {
"id": "C0033452",
"name": "properdin",
"pos": [
137,
146
]
} | {
"id": "C0005157",
"name": "beta",
"pos": [
204,
208
]
} |
the aminoacid composition of the insoluble residue of males was higher in basic amino acids ( lysine , histidine , arginine ) than the female extracts . | NA | {
"id": "C0002520",
"name": "aminoacid",
"pos": [
4,
13
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
74,
91
]
} |
the aminoacid composition of the insoluble residue of males was higher in basic amino acids ( lysine , histidine , arginine ) than the female extracts . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
74,
91
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
94,
100
]
} |
the aminoacid composition of the insoluble residue of males was higher in basic amino acids ( lysine , histidine , arginine ) than the female extracts . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
74,
91
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
115,
123
]
} |
the preponderance of avt over avp in the early gestational age mammalian fetus may represent a primative first step in molecular evolution of the neurohypophyseal peptides . | NA | {
"id": "C0042418",
"name": "avt",
"pos": [
21,
24
]
} | {
"id": "C0032017",
"name": "neurohypophyseal peptides",
"pos": [
146,
171
]
} |
as a biochemical equivalent harmaline inhibited the na+-k+-atpase and the mg2+-atpase of peritubular cell membrane fractions as well as the hco-3-stimulated atpase of a brush border membrane fraction with similar kinetics . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
52,
54
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
157,
163
]
} |
as a biochemical equivalent harmaline inhibited the na+-k+-atpase and the mg2+-atpase of peritubular cell membrane fractions as well as the hco-3-stimulated atpase of a brush border membrane fraction with similar kinetics . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
74,
77
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
157,
163
]
} |
there would appear to be a close relationship between the onset of encephalopathy and the appearance of a particular pattern in plasma amino acid equilibrium , characterised by a significant fall in the molar ratio existing between ramified amino acids ( valine , leucine , isoleucine ) and aromatic amino acids ( phenylalanine and tyrosine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
291,
311
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
314,
327
]
} |
there would appear to be a close relationship between the onset of encephalopathy and the appearance of a particular pattern in plasma amino acid equilibrium , characterised by a significant fall in the molar ratio existing between ramified amino acids ( valine , leucine , isoleucine ) and aromatic amino acids ( phenylalanine and tyrosine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
291,
311
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
332,
340
]
} |
the effect of acute and chronic treatment of rats with ipf c-45 on the following biochemical and pharmacological parameters was tested : catecholamine concentration in brain , heart and adrenals , 3h-noradrenaline uptake by cardiac muscle , the action on catecholamine synthesis following treatment with alpha-methyl-p-tyrosine , reactivity of cardiovascular system to catecholamines and isoproterenol-induced tachycardia . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
369,
383
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
388,
401
]
} |
changes in glucose levels in blood , excretion of riboflavine in urine , fad and fmn flavinic nucleotides and a total riboflavine content in liver homogenates were determined in rats . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
81,
84
]
} | {
"id": "C0035527",
"name": "riboflavine",
"pos": [
118,
129
]
} |
the lack of riboflavine in food results in a decrease of total riboflavine and fa- in liver , while during the first period of deficiency the amount of fmn increases . | NA | {
"id": "C0035527",
"name": "riboflavine",
"pos": [
12,
23
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
152,
155
]
} |
when the riboflavine demand is satisfied , low doses of atp do not influence the total riboflavine and flavinic nucleotides content in the liver , while at high doses , the total riboflavine increases and the amount of fmn initially significantly exceeds the amount of fad . | NA | {
"id": "C0035527",
"name": "riboflavine",
"pos": [
9,
20
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
219,
222
]
} |
the results indicate that apm , amd , and dmad , are less specific stimulants of central dopaminergic structures than da , and that the increase of c-amp content in the slices of rat striatum caused by apm , amd , and dmad is due to depolarizing action of these compounds . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
89,
101
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
118,
120
]
} |
the organization of proteins along dna in chromatin of saccharomyces cerevisiae ( baker 's yeast ) was examined by analyzing the dna and nucleoprotein products obtained after digestion of yeast nuclei with staphylococcal nuclease . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
20,
28
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
137,
150
]
} |
the organization of proteins along dna in chromatin of saccharomyces cerevisiae ( baker 's yeast ) was examined by analyzing the dna and nucleoprotein products obtained after digestion of yeast nuclei with staphylococcal nuclease . | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
42,
51
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
137,
150
]
} |
the results provide a framework for understanding the mechanism of peptide hormone agonism and antagonism for these compounds , and an approach for understanding some features of the interaction of the hormone and related compounds with their receptor . | NA | {
"id": "C0597192",
"name": "peptide hormone",
"pos": [
67,
82
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
202,
209
]
} |
poly ( a ) containing mrna prepared from poly ( ri ) -poly ( rc ) -induced human fibroblasts stimulated [ 14c ] leucine incorporation into protein in wheat germ cell-free extracts . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
81,
92
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
161,
165
]
} |
surprisingly mouse cells , which remove few dimers , were about as competent as control human fibroblasts at removing acetylaminofluorene lesions ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
19,
24
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} |
identification of a purified complement-fixing antigen as the epstein-barr-virus determined nuclear antigen ( ebna ) by its binding to metaphase chromosomes . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
47,
54
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
92,
107
]
} |
the activity of a ca2+-adenosinetriphosphatase ( atp phosphohydrolase , ec 3.6.1.3 ) increases during the mitotic phase of synchronized mouse mastocytoma p-815x2 cells . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
18,
21
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
49,
69
]
} |
single-stranded , linear dna of simian virus 40 ( sv40 ) created by denaturing the endonuclease ecori- or hpa ii-generated , linear , double-stranded products from form i dna of sv40 was analyzed for regions of inverted repeated sequences by visualization with the electron microscope . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
0,
15
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
134,
149
]
} |
phycobilisomes isolated from eight different species of cyanobacteria contain in addition to the light-harvesting phycobiliproteins , a small number of colorless polypeptides with molecular weights higher than those of the chromopolypeptide subunits of the phycobiliproteins . | NA | {
"id": "C0136979",
"name": "phycobilisomes",
"pos": [
0,
14
]
} | {
"id": "C0070980",
"name": "phycobiliproteins",
"pos": [
257,
274
]
} |
however , zone sedimentation of the in vivo rna product showed it to consist of partially double-stranded material sedimenting at 9 s , with little or no viral 32s rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
44,
47
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
154,
159
]
} |
the c4 precursor ( pro-c4 ) accounted for approximately 0.2 % and albumin 4 % of the radiolabeled protein precipitable by trichloroacetic acid and not bound to polysomes . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
66,
73
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
98,
105
]
} |
the sedimentation properties of vaccinia dna under denaturing conditions changed , immediately after penetration into the cell , from the characteristic circular viral dna ( crosslinked double-stranded linear dna ) to nicked circular dna or to single-stranded molecules . | NA | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
186,
201
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
225,
237
]
} |
adrenaline ( 50 microng ) and noradrenaline ( 50-250 microng ) did not produce significant effects on behaviour and sleep . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} |
cyanoethylation of anthranilic acid afforded the n-cyanoethyl derivative which on treatment with ethanolic and methanolic hydrogen chloride yielded the corresponding diethyl and dimethyl esters respectively . | NA | {
"id": "C0001962",
"name": "ethanolic",
"pos": [
97,
106
]
} | {
"id": "C0001963",
"name": "methanolic",
"pos": [
111,
121
]
} |
a previously unreported complication of closed capsulotomy is presented -- rupture of a silicone bag-gel breast implant with silicone granuloma formation . | NA | {
"id": "C0599034",
"name": "silicone",
"pos": [
88,
96
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
125,
133
]
} |
the findings of various kinds of tumors ( 306 glioblastomas , 255 astrocytomas and oligodendrogliomas , 248 meningiomas , 212 metastases , 200 pituitary adenomas and craniopharyngeomas ) are discussed and illustrated by typical images . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
46,
59
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
66,
78
]
} |
the pattern of shortening of the bones of the hand in php and pphp -- a comparison with brachydactyly e , turner syndrome , and acrodysostosis . | NA | {
"id": "C0033806",
"name": "php",
"pos": [
54,
57
]
} | {
"id": "C0033835",
"name": "pphp",
"pos": [
62,
66
]
} |
the patterns of length alterations in the hand bones in cases of pseudohypoparathyroidism ( php ) , pseudopseudohypoparathyroidism ( pphp ) , and acrodysostosis were evaluated . | NA | {
"id": "C0033806",
"name": "pseudohypoparathyroidism",
"pos": [
65,
89
]
} | {
"id": "C0033835",
"name": "pseudopseudohypoparathyroidism",
"pos": [
100,
130
]
} |
the pattern profiles thus generated showed that those for php and pphp are almost identical , and are similar to that seen in acrodysostosis , except for the much smaller size of the bones seen in the latter condition . | NA | {
"id": "C0033806",
"name": "php",
"pos": [
58,
61
]
} | {
"id": "C0033835",
"name": "pphp",
"pos": [
66,
70
]
} |
php and pphp are probably differend manifestations of the same entity , and acrodysostosis may also be related to them . | NA | {
"id": "C0033806",
"name": "php",
"pos": [
0,
3
]
} | {
"id": "C0033835",
"name": "pphp",
"pos": [
8,
12
]
} |
the usable 125i-labelled antigen for human proinsulin-c-peptide ria could be prepared by chloramin t method and enzymic method wich labelled 125i to tyrosyl human proinsulin connecting peptide , and active ester method which conjugates 125i-labelled active ester to human proinsulin connecting peptide . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
43,
53
]
} | {
"id": "C0006558",
"name": "connecting",
"pos": [
283,
293
]
} |
when lysates of erythrocytes of 11 species , including man , were incubated at ph 7.8 with l-3-methoxy-4-hydroxy [ u-14c ] phenylalanine or with [ 7-3h ] normetanephrine , these were demethylated and formed 3,4-dihydroxy [ 14c ] phenylalanine or [ 3h ] norepinephrine . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
154,
169
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
253,
267
]
} |
the binding of 3h-enkephalin ( methionine-enkephalin ) to membranes of rat brain is inhibited by enkephalin and levorphanol with ic50 values of 5 and 1.6 nm , respectively . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
18,
28
]
} | {
"id": "C0014295",
"name": "methionine-enkephalin",
"pos": [
31,
52
]
} |
opiate agonists , morphine , dihydromorphine and l-methadone and opiate antagonists , naltrexone and naloxone are less effective inhibitors of 3h-enkephalin than in 3h-dihydromorphine and 3h-naloxone binding . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
86,
96
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
191,
199
]
} |
the avirulent strains and those of low virulence were capable of absorbing protective antibodies from rabbit antisera to type strains of human encapsulated s aureus . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
86,
96
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
109,
117
]
} |
positive staining with anti-saa antisera was localized to the cytoplasm of cells scattered within the mesenchymal stroma , thought to be fibroblasts , and to foetal stem vessel endothelium and some individual fibrillar structures in villous stroma and perivascular tissue . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
75,
80
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
137,
148
]
} |
during and/or after the exercise test 80 % of the men and 70 % of the women had no major st- and t-wave changes , arrhythmias or ectopic beats . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
114,
125
]
} | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
129,
142
]
} |
those subjects who had arrhythmias or ectopic beats at rest , had in general no such changes during and/or after the exercise test . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
23,
34
]
} | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
38,
51
]
} |
in more than half of the cases the cor pulmonale was caused by lung diseases associated with chronic bronchitis and emphysema or with fibrosis of the lung . | NA | {
"id": "C0024115",
"name": "lung diseases",
"pos": [
63,
76
]
} | {
"id": "C0034069",
"name": "fibrosis of",
"pos": [
134,
145
]
} |
the tissular pharmacokinetics of antibiotics were studied by sacrificing rats in groups of 6 at various intervals after the injection of ampicillin , cephalothin , doxycycline , gentamicin and sisomicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
178,
188
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
193,
202
]
} |
among secondary forms of hypertension ( 7.1 % ) renal hypertension , with a rate of 5.8 % , was the commonest form ( hypertension of renal-parenchymatous origin 4.9 % , renovascular hypertension 0.8 % , hypertension associated with unilateral hydronephrosis 0.1 % . | NA | {
"id": "C0020544",
"name": "hypertension",
"pos": [
25,
37
]
} | {
"id": "C0020545",
"name": "renovascular",
"pos": [
169,
181
]
} |
the results are incompatible with the prediction that only one gamma- or beta-globin gene may be active in any single chromosome and provide further evidence for incomplete repression of gamma-globin genes lying cis to active beta-globin genes . | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
187,
199
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
226,
237
]
} |
two cases of granulocytopenia and leukopenia developing after high-dosage oxacillin therapy given intravenously are described . | NA | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
13,
29
]
} | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
34,
44
]
} |
leukopenia and granulocytopenia as adverse effects of oxacillin therapy should be kept in mind , especially when high dosages are used . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
0,
10
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
15,
31
]
} |
clindamycin , like the related antibiotic lincomycin , appears to have significant intestinal toxicity and should be restricted to the treatment of life-threatening proven bacteroides infections . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
0,
11
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
42,
52
]
} |
at least 4 possible mechanisms may be postulated to explain the neural manifestations of acute porphyria in the hereditary hepatic porphyrias . | NA | {
"id": "C0162565",
"name": "acute porphyria",
"pos": [
89,
104
]
} | {
"id": "C0162533",
"name": "hepatic porphyrias",
"pos": [
123,
141
]
} |
hh genes are regarded as determinants of cell surface antigens ( hh antigens ) phenotypically expressed , in contrast to histocompatibility antigens ( h antigens ) only on blood-forming and leukemic cells . | NA | {
"id": "C0003316",
"name": "determinants",
"pos": [
25,
37
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
153,
161
]
} |
the ann arbor classification of malignant lymphomas is interpreted in detail , and , in consideration of the diagnosis of non-hodgkin 's lymphomas , modifications are proposed . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
32,
51
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
122,
146
]
} |
314 patients with non-hodgkin 's lymphomas of low-grade-malignancy ( chronic lymphocytic leukemia , lymphoplasmacytoid , centrocytic , centrocytic , centroblastic-centrocytic lymphoma ) manifested significantly higher median survival times than the 91 patients with non-hodgkin 's lymphomas of high-grade malignancy ( lymphoblastic and immunoblastic lymphoma ) . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
18,
42
]
} | {
"id": "C0079746",
"name": "immunoblastic lymphoma",
"pos": [
336,
358
]
} |
diabetics with advanced periodontal diseases ( gingival recession , periodontitis and pockets ) , such as parodontopathia inflammata profunda , showed the highest ci value ( 1.88 ) which also differed significantly from the ci values for diabetics with healthy gingivae or with parodontopathia inflammata superficialis . | NA | {
"id": "C0017563",
"name": "periodontal diseases",
"pos": [
24,
44
]
} | {
"id": "C0017572",
"name": "gingival recession",
"pos": [
47,
65
]
} |
although semiallogeneic cells gave the better antigenic stimulus at lower cell doses ( 0.3 and 3 x 10 ( 6 ) cells ) , allogeneic cells were better at higher cell doses ( 30 and 150 x 10 ( 6 ) cells ) . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
13,
29
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
monocytes represented 41 % of b-cell-enriched preparations and gave rise to extra reactions due to monocyte antibodies in allo immune sera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
108,
118
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
127,
138
]
} |
mathematical computer-assisted programs developed to aid in determining clusters of amino acid variables suggested that excretion of glycine , leucine , proline , and glutamic acid in men and concentrations of valine , serine , aspartic acid , phenylalanine , and lysine in women vary according to the invasiveness of the disease . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
84,
94
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
133,
140
]
} |
an associated thiamine deficiency was evidenced by decreased thiamine levels in the blood of one dog and in the food of another , and rapid remission of clinical signs in a dog given thiamine hydrochloride . | NA | {
"id": "C0039840",
"name": "thiamine",
"pos": [
14,
22
]
} | {
"id": "C0770309",
"name": "thiamine hydrochloride",
"pos": [
183,
205
]
} |
it is suggested that the protection afforded by this hyperimmune serum is due to high levels of specific antibody demonstrable in the serum of calves post treatment and that protection is given in this instance by antibodies contained in the igg class of immunoglobulins . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
214,
224
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
246,
251
]
} |
the nafenopin induced hepatomegaly therefore appears to arise from a combination of cell proliferation , as well as , cellular hypertrophy , which is associated with peroxisome proliferation . | NA | {
"id": "C0019209",
"name": "hepatomegaly",
"pos": [
22,
34
]
} | {
"id": "C0020564",
"name": "hypertrophy",
"pos": [
127,
138
]
} |
sindbis virus messenger rna : the 5'-termini and methylated residues of 26 and 42 s rna . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
14,
27
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
84,
87
]
} |
[ migration of radon daughters and absorbed dose distribution in relation to skin depth during radon baths ] . | NA | {
"id": "C0072962",
"name": "radon daughters",
"pos": [
15,
30
]
} | {
"id": "C0034629",
"name": "radon",
"pos": [
95,
100
]
} |
content of lithium was quite unaltered in rat blood serum after administration of lithium carbonate at a dose of 50 mg/kg ; | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
11,
18
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
82,
99
]
} |
content of normal ig was distinctly decreased and monoclonic ig ( paraprotein ) was found in paraproteinemic hemoblastoses . | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
18,
20
]
} | {
"id": "C0030490",
"name": "paraprotein",
"pos": [
93,
104
]
} |
under study were the content of serotonin and 11-ocs in blood and diurnal excretion of 5-oiaa , adrenaline and noradrenaline in 71 pateints with breast cancer . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
111,
124
]
} |
the data obtained indicated that the examined patients , compared with the control group , show a reliably higher concentration of serotonin and 11-ocs in blood ( 70.4 % and 19.5 % correspondingly ) , an insignificantly increased excretion of 5-oiaa , a markedly increased diurnal excretion of adrenaline ( by 96.4 % ) , whereas a decreased excretion of noradrenaline ( by 73.1 % ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
294,
304
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
354,
367
]
} |
various lots of human serum albumin , prepared by the cohn alcohol procedure , were assayed for polymer distribution after lyophilization or acetone drying of the albumin paste . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
16,
35
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
163,
170
]
} |
p antigen is reexpressed on polykaryon cells obtained by fusion of pk x p fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
39,
44
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
74,
85
]
} |
precipitating antibodies to cellular antigens in sjogren 's syndrome , rheumatoid arthritis , and other organ and nonorgan-specific autoimmune diseases . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
49,
68
]
} | {
"id": "C0003873",
"name": "rheumatoid",
"pos": [
71,
81
]
} |
the prevalence of three precipitating antibodies , anti-ss-a anti-ss-b , and rheumatoid arthritis precipitin ( rap ) , reacting with an extract of the human lymphoid cell line wil2 , was studied in the sicca syndrome , sjogren 's syndrome with rheumatoid arthritis , rheumatoid arthritis , various seronegative spondyloarthritides , and organ and nonorgan-specific autoimmune disease . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
219,
238
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
267,
287
]
} |
however , the data did not support previous studies where patients with sicca syndrome had a high incidence of anti-ss-a and/or -ss-b antibodies but had a low frequency of rap , and patients with sjogren 's syndrome in association with rheumatoid arthritis had a high incidence of rap but a low incidence of anti-ss-a and/or -ss-b . | NA | {
"id": "C1527336",
"name": "sjogren 's",
"pos": [
196,
206
]
} | {
"id": "C0003873",
"name": "rap",
"pos": [
281,
284
]
} |
prostaglandin productive capacity , measured by radioimmunoassay , showed the polymorphonuclear leucocyte rich populations from synovial effusions to be poor sources of pge production whereas the synovial fragments produced substantial amounts of pge activity . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
0,
13
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
247,
250
]
} |
cushing 's disease , due to excessive pituitary acth resulting in adrenocortical hyperplasia , remains a complex endocrine disorder for which no single treatment is wholly satisfactory . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
38,
47
]
} | {
"id": "C0014130",
"name": "endocrine disorder",
"pos": [
113,
131
]
} |
amino acid derangements in patients with sepsis : treatment with branched chain amino acid rich infusions . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0002521",
"name": "branched chain",
"pos": [
65,
79
]
} |
the plasma amino acid pattern observed was characterized by an increase in total amino acid content , due mainly to high levels of the aromatic amino acids ( phenylalanine and tyrosine ) and the sulfur-containing amino acids ( taurine , cystine and methionine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
135,
155
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
158,
171
]
} |
the plasma amino acid pattern observed was characterized by an increase in total amino acid content , due mainly to high levels of the aromatic amino acids ( phenylalanine and tyrosine ) and the sulfur-containing amino acids ( taurine , cystine and methionine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
135,
155
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
176,
184
]
} |
the branched chain amino acids ( valine , leucine and isoleucine ) were within normal limits , as were glycine , serine , threonine , lysine , histidine and tryptophan . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
4,
30
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
33,
39
]
} |
the branched chain amino acids ( valine , leucine and isoleucine ) were within normal limits , as were glycine , serine , threonine , lysine , histidine and tryptophan . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
4,
30
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
57,
64
]
} |
the branched chain amino acids ( valine , leucine and isoleucine ) were within normal limits , as were glycine , serine , threonine , lysine , histidine and tryptophan . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
4,
30
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
54,
64
]
} |
in a second group of five patients with overwhelming sepsis accompanied by a state of metabolic encephalopathy , a parenteral nutrition solution consisting of 23 % dextrose , and an amino acid formulation enriched with branched chain amino acids was administered . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
182,
192
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
219,
245
]
} |
antidepressant activity is characterized by its ability to inhibit tetrabenazine-induced depression , antagonize reserpine-induced hypothermia and enhance yohimbine lethality . | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
113,
122
]
} | {
"id": "C0724441",
"name": "lethality",
"pos": [
165,
174
]
} |
cytidine and thymidine closely related in structure to deoxycytidine , are interchangeable with saline as controls , indicating a high degree of specificity in the receptor involved in the `` '' action-effects '' '' sequence . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
0,
8
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
55,
68
]
} |
five of 11 normotensive patients with congestive heart failure responded to an infusion of the specific angiotensin ii antagonist , saralasin , by reducing systemic vascular resistance from 2274 +/- 418 to 1690 +/- 351 dynes/sec/cm-5 ( mean +/- standard error ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
104,
118
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
132,
141
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.