text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
netilmicin ( sch 20569 ) , sisomicin , gentamicin and kanamycin were administered i.v . in the rat and the following effects were studied : neuromuscular blocking activity ( sciatic-gastrocnemius preparation ) , and acute toxicity evaluation . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
0,
10
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
27,
36
]
} |
netilmicin ( sch 20569 ) , sisomicin , gentamicin and kanamycin were administered i.v . in the rat and the following effects were studied : neuromuscular blocking activity ( sciatic-gastrocnemius preparation ) , and acute toxicity evaluation . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
27,
36
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
39,
49
]
} |
comparison of results gave a sequence of relative potency which was as follows : netilmicin = sisomicin greater than gentamicin greater than kanamycin . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
81,
91
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
94,
103
]
} |
comparison of results gave a sequence of relative potency which was as follows : netilmicin = sisomicin greater than gentamicin greater than kanamycin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
94,
103
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
117,
127
]
} |
the incorporation of tri c8 : o into the diet did not change the fatty acid composition of body lipid stores while the incorporation of tri c12 : o induced a lipogenesis characterized by the disappearance of about 50 % of the n-9 and n-7 unsaturated fatty acids , the emergence of an equivalent amount of saturated fatty acids in c12 and c14 , and the decrease of hexadecanoic or palmitic acid concentration . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
65,
75
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
238,
261
]
} |
the condition developed slowly over the course of years towards a maximum incidence of several short daily attacks of an arrhythmia which alternated between an atrial fibrillation and atrial flutter . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
121,
131
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
160,
179
]
} |
the condition developed slowly over the course of years towards a maximum incidence of several short daily attacks of an arrhythmia which alternated between an atrial fibrillation and atrial flutter . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
121,
131
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
184,
198
]
} |
this new technique should be useful in the electrodiagnostic evaluation of peripheral neuropathy , femoral neuropathy and saphenous nerve entrapment syndrome . | NA | {
"id": "C0031117",
"name": "peripheral neuropathy",
"pos": [
75,
96
]
} | {
"id": "C0027743",
"name": "nerve entrapment",
"pos": [
132,
148
]
} |
the biological behavior of a highly passaged vaccine strain of mumps virus ( jeryl-lynn ) is more similar to nmv than to the wild strain in its behavior in the newborn hamster . | NA | {
"id": "C0026782",
"name": "vaccine",
"pos": [
45,
52
]
} | {
"id": "C0026783",
"name": "nmv",
"pos": [
109,
112
]
} |
however , this does not imply that the muscle cell membrane is not involved in the underlying pathological processes in this disorder . | NA | {
"id": "C0030660",
"name": "pathological processes",
"pos": [
94,
116
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
125,
133
]
} |
in addition , treatment of calves with phenobarbitone or melaleuca linariifolia essential oils prior to dosing with the myoporum oils caused periportal hepatic necrosis rather than the centrilobular lesion which occurred usually in this species . | NA | {
"id": "C0028910",
"name": "essential oils",
"pos": [
80,
94
]
} | {
"id": "C0028908",
"name": "oils",
"pos": [
129,
133
]
} |
under conditions of postive inotropism caused by application of noradrenaline , adrenaline or increased extracellular ca++ concentration , the proportionality between tension and stiffness is maintained ( 13 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} |
49000 , which was the most labelled protein in adult tissues , was also one of the major phosphoproteins in foetal and neoplastic tissues . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
36,
43
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
89,
104
]
} |
cyclic amp and 8-bromo cyclic amp were most effective , giving k ( a ) values of 0.08 and 0.09mum and i ( 50 ) of 0.12 and 0.16mum respectively . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
0,
10
]
} | {
"id": "C0000661",
"name": "8-bromo cyclic amp",
"pos": [
15,
33
]
} |
in normal cultures the glycosaminoglycans of the pericellular pool ( trypsin-susceptible material ) , the membrane fraction ( trypsin-susceptible material of edta-detached cells ) and the substrate-attached material consisted mainly of heparan sulphate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
23,
41
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
236,
252
]
} |
among the sulphated glycosaminoglycans chondroitin sulphate , rather than heparan sulphate , was the predominant species of the pericellular pool . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
20,
38
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
74,
90
]
} |
an early response to the administration of oestradiol-17 beta to immature rats is a dramatic stimulation in the synthesis of uterine hnrna ( heterogenous nuclear rna ) . | NA | {
"id": "C0035695",
"name": "hnrna",
"pos": [
133,
138
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
154,
165
]
} |
the dna in this fraction was identified as ribosomal dna on the basis of its density and molecular weight , and it appears not to be appreciably contaminated by other dna . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
43,
56
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
167,
170
]
} |
the method relies on the approximate assumption that ribosomal dna is the smallest species of dna in chromatin in the nucleus , and avoids the use of mechanical force , or enzyme action , to fractionate chromatin . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
53,
66
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
94,
97
]
} |
an apparently cross-reacting protein present in the 0.05m-nacl eluate from the deae-cellulose column was serologically unrelated to hexosaminidase , but it gave a reaction of immunological identify with one of the apparently cross-reacting proteins having the charge and size characteristics of hexosaminidase a . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
132,
146
]
} | {
"id": "C0162330",
"name": "hexosaminidase a",
"pos": [
295,
311
]
} |
more than ten new types of gangliosides , in addition to haematoside and sialosylparagloboside , were isolated from human erythrocyte membranes . | NA | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
27,
39
]
} | {
"id": "C0016897",
"name": "haematoside",
"pos": [
57,
68
]
} |
binding of nad+ and trifluoroethanol , an unreactive alcohol , gave maximal fluorescence quenching at ph7 with all three enzymes . | NA | {
"id": "C0040983",
"name": "trifluoroethanol",
"pos": [
20,
36
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
53,
60
]
} |
the acetimidylated enzyme -- nad+ -- trifluoroethanol complex had an apparent pka of 5.0 , but the pk of the native enzyme complex was experimentally inaccessible . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
19,
25
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
116,
130
]
} |
it is in this age , when characteristic pathological processes do occur , mainly digestive abnormalities , neonatal nectrotizing enterocolitis , hirschsprung 's disease and others . | NA | {
"id": "C0266015",
"name": "digestive abnormalities",
"pos": [
81,
104
]
} | {
"id": "C0019569",
"name": "hirschsprung 's disease",
"pos": [
145,
168
]
} |
the present paper describes a case of spondyloepiphyseal dysplasia congenita ( s.d.c . ) , a heritable bone dysplasia manifested at birth and characterized by short stature and retarded ossification of vertebral bodies , pelvis and extremities . | NA | {
"id": "C0005941",
"name": "bone dysplasia",
"pos": [
103,
117
]
} | {
"id": "C0013336",
"name": "short stature",
"pos": [
159,
172
]
} |
1 cross-reactivity of ergot alkaloids with an antiserum produced against lysergic acid conjugated with human serum , albumin was utilized to develop a radioimmunoassay for ergotamine , dihydroergotamine , dihydroergotoxine , ergometrine and methylergometrine in biological fluids . | NA | {
"id": "C0014704",
"name": "ergometrine",
"pos": [
225,
236
]
} | {
"id": "C0025760",
"name": "methylergometrine",
"pos": [
241,
258
]
} |
ascorbic acid and dehydroascorbic acid in hela cells : their effect on the collagen-peptidase activity of glucose-deficient cultures . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
0,
13
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
18,
38
]
} |
hela cells in culture do not accumulate ascorbic acid unless ascorbic acid or dehydroascorbic acid is available in the medium . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
40,
53
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
78,
98
]
} |
the outcome of pregnancy was ascertained in 96 per cent of patients : 13 cases of anencephaly and 7 of open spina bifida were detected by plasma screening and a further 3 cases of open ntd through the mother 's previous medical history and amniotic fluid determination . | NA | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
82,
93
]
} | {
"id": "C0027794",
"name": "ntd",
"pos": [
185,
188
]
} |
the patients whose diabetes was diagnosed during pregnancy had significantly heavier babies ( 18 pregnancies , mean birth weight 3337 g ) than the established diabetics ( 83 pregnancies , mean weight 3011 g ) despite significantly lower fasting blood glucose levels in the former and similar mean gestational ages at delivery . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
116,
128
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
193,
199
]
} |
maternal venous and umbilical venous and arterial blood samples were taken at delivery and analyzed for individual fatty acid concentrations in triglyceride , free fatty acid ( ffa ) and phospholipid fractions . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
115,
125
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
159,
174
]
} |
the fetal lipids were also altered and the infusions resulted in large positive umbilical venous-arterial ( v-a ) differences in ffa and triglyceride fatty acid concentrations , but this was not the case for phospholipid concentrations . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
129,
132
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
150,
160
]
} |
this behavior of the phospholipid head groups in ldl is similar to that in small vesicles without cholesterol , suggesting that in ldl most of the cholesterol is not associated with mobile , surface phospholipids . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
98,
109
]
} | {
"id": "C0023824",
"name": "ldl",
"pos": [
131,
134
]
} |
cholesterol in one environment , representing approximately 50 % of the total unesterified cholesterol , is readily exchanged with the cholesterol of high-density lipoproteins , with a half-time of about 4 h at 37 degrees c . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
135,
146
]
} |
the requirement for ribothymidine and pseudouridine in the tpsicg loop of trna for its activity in the ribosome and trna-stimulated synthesis of guanosine 5'-triphosphate 3'-diphosphate ( pppgpp ) by stringent factor has been tested by the use of a purified trnaphe ( 883 pmol of phenylalanine incorporated/a260 unit ) in which 92 % of the pseudouridine , 98 % of the ribothymidine , 98 % of the dihydrouridine , and 88 % of the uridines were substituted by 5-fluorouridine . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
38,
51
]
} | {
"id": "C0041984",
"name": "uridines",
"pos": [
429,
437
]
} |
some of the properties of the vibrio collagenase are compared with those of clostridium histolyticum collagenase . | NA | {
"id": "C0162745",
"name": "collagenase",
"pos": [
37,
48
]
} | {
"id": "C0009053",
"name": "clostridium histolyticum collagenase",
"pos": [
76,
112
]
} |
the modified enzymes have a marked preference for hydrophobic amino acids : the rates of oxidation decrease in the series d-phenylalanine , d-methionine , d-norleucine , d-norvaline , d-alpha-aminobutyrate , d-alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
62,
73
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
210,
217
]
} |
in addition , the observed kms of the amino acids are increased , especially those of the smaller substrates ( d-alanine and d-alpha-aminobutyrate ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
113,
120
]
} |
in the dark , the dipeptide is a reversible inhibitor of glycylglycine uptake by live e. coli w cells . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
18,
27
]
} | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
57,
70
]
} |
when intact e. coli cells are photolyzed at approximately 350 nm in the presence of the photolabile dipeptide , their ability to transport either glycylglycine or unphotolyzed glycyl-4-azido-2-nitro-l-phenylalanine is irreversibly inhibited , but their ability to transport arginine is unaffected . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
100,
109
]
} | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
146,
159
]
} |
the amino acid sequence of these peptides was determined by automated edman degradation of tryptic ( before and after maleylation ) , chymotryptic , thermolytic or hydroxylamine-derived peptide fragments as well as the intact peptides . | NA | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
186,
203
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
226,
234
]
} |
valyl-trna synthetase , as well as activating a number of amino acid analogues , will accept alanine , cysteine , isoleucine , and serine in addition to threonine as substrates for both atp-ppi exchange and transfer to some trnaval species . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
58,
68
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
93,
100
]
} |
this is in a size range expected for messenger rna , a possibility which is also supported by the observation that pulse-labeled rna has a considerably higher poly ( a ) content than long-term labeled rna . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
37,
50
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
201,
204
]
} |
after passage of the hybridization mixture through a nitrocellulose column to remove single-strand dna and dna -- rna hybrids , the eluent was measured for its capacity to promote deoxynucleotide kinase ( gene 1 ) synthesis in an in vitro protein-synthesizing system derived from uninfected escherichia coli . | NA | {
"id": "C0012935",
"name": "single-strand dna",
"pos": [
85,
102
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
107,
110
]
} |
the chemical composition of these six novel lipids shows them to be related to the previously characterized phosphosphingolipids psl-i , n-acetylglucosamine [ glucuronic acid , inositol phosphate ] ceramide and psl-ii , glucosamine [ glucuronic acid , inositol phosphate ] ceramide [ kaul , k. , and lester , r . l. ( 1975 ) , plant physiol . 55 , 120 ] . | NA | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
137,
156
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
220,
231
]
} |
measurement of the time-resolved fluorescence depolarization of 1,6-diphenylhexatriene ( dph ) in artificial bilayers of microsomal membrane lipids from tetrahymena gives detailed information concerning the molecular motion of this probe and fluid properties of the membrane lipids which are obscured with steady-state methods . | NA | {
"id": "C0023768",
"name": "bilayers",
"pos": [
109,
117
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
266,
281
]
} |
the amino acid composition indicates hydrophobicity ( 39 % polarity ) and a high content of basic amino acid such as lysine and arginine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
92,
108
]
} |
the amino acid composition indicates hydrophobicity ( 39 % polarity ) and a high content of basic amino acid such as lysine and arginine . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
92,
108
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
117,
123
]
} |
the amino acid composition indicates hydrophobicity ( 39 % polarity ) and a high content of basic amino acid such as lysine and arginine . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
92,
108
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
128,
136
]
} |
through a comparison with resonance raman spectra of 15,15'-cis-beta-carotene , these carotenoids are shown to assume cis conformations , while the corresponding chromatophores contain all-trans forms only . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
64,
77
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
86,
97
]
} |
on the basis of the structure-activity relationships for butyrylcholinesterase and acetylcholinesterase the specificities of the enzymes are compared and some common features are discussed . | NA | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
57,
78
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
83,
103
]
} |
formycin triphosphate ( ftp ) , a fluorescent analogue of atp , is a substrate for ( na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) , with properties similar to those of atp . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
47,
49
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
106,
126
]
} |
fluorescence measurements have shown that formycin triphosphate ( ftp ) or formycin diphosphate ( fdp ) bound to ( na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) in na+-containing media can be displaced by the following ions ( listed in order of effectiveness ) : tl+ , k+ , rb+ , nh4+ , cs+ . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
115,
117
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
136,
156
]
} |
guanylyl- ( beta , gamma-methylene ) -diphosphonate and guanylyl-imidodiphosphate , analogues of gtp , served as substrates of guanylate cyclase in the purified enzyme preparation . | NA | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
56,
81
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
97,
100
]
} |
a mechanism for the reduction and oxidation of methyl viologen by clostridium pasteurianum hydrogenase ( hydrogen : ferredoxin oxidoreductase , ec 1.12.7.1 ) is proposed . | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
91,
102
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
144,
148
]
} |
addition of oxidized electron carriers inhibits the hydrogen-deuterium exchange reaction ( i.e. , the exchange of protons between h2 and 2h2o ) . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
52,
60
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
61,
70
]
} |
the effects of two lectins , wheat germ agglutinin and concanavalin a , were studied on a variety of parameters of two highly purified ( na+ + k+ ) -atpases ( atp phosphohydrolase , ec 3.6.1.3 ) , from the rectal salt gland of squalus acanthias and from the electroplax of electrophorus electricus . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
60,
62
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
159,
179
]
} |
in vitro dissociation and reassociation of purified enzymes showed that the three major isozymes had homotetrameric structures . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
52,
59
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
88,
96
]
} |
the neurospora crassa assimilatory nadph-nitrite reductase ( nad ( p ) h : nitrite oxidoreductase , ec 1.6.6.4 ) , which catalyzes the nadph-dependent formation of ammonia from nitrite , has been purified to homogeneity as judged by polyacrylamide gel electrophoresis . | NA | {
"id": "C0068815",
"name": "assimilatory",
"pos": [
22,
34
]
} | {
"id": "C0028135",
"name": "nitrite",
"pos": [
177,
184
]
} |
on the mechanism for the regulation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase , of cholesterol 7alpha-hydroxylase and of acyl-coenzyme a : cholesterol acyltransferase by free cholesterol . | NA | {
"id": "C0009226",
"name": "coenzyme a",
"pos": [
66,
76
]
} | {
"id": "C0001374",
"name": "acyl-coenzyme a",
"pos": [
130,
145
]
} |
the administration of mevalonic acid to rats by intravenous injection resulted in a dose- and time-dependent increase in the activity of cholesterol 7alpha-hydroxylase in the liver microsomal fraction , a decrease in the microsomal activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and no significant change in the activity of acyl-coenzyme a : cholesterol acyltransferase or in the concentration of free and of esterified cholesterol in the liver microsomal fraction . | NA | {
"id": "C0009226",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0001374",
"name": "acyl-coenzyme a",
"pos": [
337,
352
]
} |
the administration of mevalonic acid to rats by stomach tube resulted in an increase in the activity of cholesterol 7alpha-hydroxylase and of acyl-coenzyme a : cholesterol acyltransferase and in the concentration of cholesterol esters in the liver microsomal fraction , while there was a considerable decrease in the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase . | NA | {
"id": "C0001374",
"name": "acyl-coenzyme a",
"pos": [
142,
157
]
} | {
"id": "C0009226",
"name": "a",
"pos": [
373,
374
]
} |
binding of tracer 125i-labeled insulin , which was competitively inhibited by native insulin as well as by proinsulin and analogs of insulin and proinsulin in proportion to their biological activity , was not influenced by glucagon , corticotropin , or human growth hormone . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
31,
38
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
145,
155
]
} |
the enzyme of mononucleated myoblasts was found to be activated by adrenaline l , noradrenaline l , and to a small extent , by adrenaline d and dihydrocymandelic acid . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
82,
95
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
127,
137
]
} |
the adenylate cyclase of the differentiated cells responded to adrenaline l and noradrenaline l but not to adrenaline d or dihydroxymandelic acid . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
80,
93
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
107,
117
]
} |
the insoluble residue , comprising about 10 per cent of the membrane protein , contained mainly the protein spiralin , which is quantitatively the major one of this membrane . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
60,
76
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
100,
107
]
} |
inhibitory effects of melatonin , prostaglandin e1 , cyclic amp , dibutyrylcyclic amp and theophylline on rat seminiferous tubular contractility in vitro . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
53,
63
]
} | {
"id": "C0012054",
"name": "dibutyrylcyclic",
"pos": [
66,
81
]
} |
with the same batches of labelled albumin , we measured the serum albumin catabolism , in a similar way , in a group of 19 normal subjects , for two weeks , without gastric intubation . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
34,
41
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
60,
73
]
} |
simultaneous determination of diphenylhydantoin , mephobarbital , carbamazepine , phenobarbital and primidone in serum using direct chemical ionization mass spectrometry . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
82,
95
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
100,
109
]
} |
a mathematical model has been employed to examine the interplay of reaction and mass transfer in immobilized enzyme systems involving reaction-generated enzyme poisions . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
97,
115
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
153,
159
]
} |
[ noradrenaline and adrenaline concentration in the myocardium of persons who have died suddenly or from injuries ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
2,
15
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
20,
30
]
} |
to investigate mechanisms of sudden death the authors determined the content of noradrenaline and adrenaline in the myocardium of different heart sections in deceased persons by the fluorimetric method ; | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
80,
93
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
98,
108
]
} |
the differences in the adrenaline and noradrenaline content in the heart chambers of persons who died of trauma and suddenly indicated the death mechanisms to be different in these cases . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
23,
33
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
the rna content in the hepatocytes diminished on account of reduction of the nuclear rna fraction closely bound with chromatin . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
4,
7
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
77,
88
]
} |
following fe treatment less than 1 % of clonogenic fibroblast precursors which gave rise to fibroblast colonies under conditions of monolayer cultures remained in the bone marrow cell suspension , and about 10 % -- in the spleen and the peritoneal exudate cell suspension . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
51,
61
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
256,
260
]
} |
fetal hemoglobin in paroxysmal nocturnal hemoglobinuria ( pnh ) : evidence for derivation of hbf-containing erythrocytes ( f cells ) from the pnh clone as well as from normal hemopoietic stem cell lines . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
125,
130
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cell",
"pos": [
175,
196
]
} |
the observed frequencies of f cells in normal cells best fitted those expected under the assumption that the f cells arise equally from normal hemopoietic stem cells and from the stem cells with the pnh defect . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
143,
165
]
} |
the 10 000 g particulate fraction from capillary-enriched fractions isolated from rat cerebral cortex was shown to possess an adenylate cyclase highly sensitive to activation by sodium fluoride , norepinephrine , epinephrine , isoproterenol and dopamine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
196,
210
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
213,
224
]
} |
investigating the possibility that indomethacin could affect the binding of angiotensin ii , it was found that at doses of indomethacin higher than 10 ( -5 ) m , binding of tritiated angiotensin to isolated adrenal cortical cells was reduced . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
76,
90
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
183,
194
]
} |
complications of the procedure reported by referring clinicians over 10 years comprised four cases of necrosis of the dorsum of the foot and two of gangrene of the foot , in one of which the gangrene spread to the leg . | NA | {
"id": "C0027540",
"name": "necrosis",
"pos": [
102,
110
]
} | {
"id": "C0017086",
"name": "gangrene",
"pos": [
191,
199
]
} |
the interaction of baclofen ( beta- ( 4-chlorophenyl ) gaba ) with gaba systems in rat brain : evidence for a releasing action . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
19,
27
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
67,
71
]
} |
circadian rhythms in urinary water , sodium , potassium and proteins excretion are studied in 45 rats living alone in metabolism cages . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
69,
78
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
118,
128
]
} |
[ effect of isoprenaline , in mice anesthetized with pentobarbital , on the cerebral concentration of barbiturates and on the blood levels of free fatty acids ] . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
53,
66
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
102,
114
]
} |
a noticeable discontinuity was detected at 10 -- 12 degree c with 12- or 16-doxyl stearic acid containing membrane lipids which was attributed to the spin-labelled lipid -- microsomal membrane protein interactions since no such discontinuity was detected in liposomes prepared from total lipid extracts of microsomal membranes . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
106,
121
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
288,
293
]
} |
the effect of phosphorylcholine in promoting the interaction between heparin and pure chylomicrons or very low density lipoproteins was regained when a crude serum protein factor of unwashed chylomicrons was added to the system , suggesting that rat serum contains a protein factor ( s ) which normally inhibits the heparin -- lipoprotein interaction by raising the requirement of ca2+ . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
102,
131
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
327,
338
]
} |
the effect of phosphorylcholine in promoting the interaction between heparin and pure chylomicrons or very low density lipoproteins was regained when a crude serum protein factor of unwashed chylomicrons was added to the system , suggesting that rat serum contains a protein factor ( s ) which normally inhibits the heparin -- lipoprotein interaction by raising the requirement of ca2+ . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
86,
98
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
327,
338
]
} |
the nucleotide sequence in wheat embryo ribosomal 5s rna that binds by complementary base pairing to ribosomal 18s rna has been identified . | NA | {
"id": "C0035707",
"name": "ribosomal 5s rna",
"pos": [
40,
56
]
} | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
101,
110
]
} |
similarly , the concentration of phosphocholine was estimated by the formation of 3h-labelled cdp-choline from 3h-labelled ctp . | NA | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
33,
47
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
98,
105
]
} |
a cell-free extract of escherichia coli , even after exhaustive dialysis , was found capable of phosphorylating adenosine 5'-monophosphate ( amp ) to adenosine 5'-diphosphate ( adp ) and adenosine 5'-triphosphate ( atp ) . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
112,
123
]
} | {
"id": "C0001459",
"name": "adenosine",
"pos": [
187,
196
]
} |
a cell-free extract of escherichia coli , even after exhaustive dialysis , was found capable of phosphorylating adenosine 5'-monophosphate ( amp ) to adenosine 5'-diphosphate ( adp ) and adenosine 5'-triphosphate ( atp ) . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
112,
123
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
187,
198
]
} |
the recovery of viral antigen in a pure form from tissue can be hindered by the small amount of antigen present relative to the remaining normal tissue constituents with which the antigen may form loose associations . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
16,
29
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
180,
187
]
} |
the action of bradykinin on this receptor can be prevented with the use of specific and competitive inhibitors and , therefore , the mesenteric vein will distinguish between peptides of the kinins or of the substance p types . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
14,
24
]
} | {
"id": "C0022714",
"name": "kinins",
"pos": [
190,
196
]
} |
primidone is an effective anticonvulsant against seizures induced in epileptic fowl by exposure to intermittent photic stimulation . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
49,
57
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
69,
78
]
} |
pretreatment of epileptic fowl with skf 525a to prevent the metabolism of primidone to phenobarbital indicated that primidone itself had anticonvulsant activity . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
87,
100
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
116,
125
]
} |
in a previously healthy 13-year-old girl with disseminated blastomycosis , immunodeficiency was considered because of lymphopenia and the slow response of her lung disease to therapy with amphotericin b . | NA | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
75,
91
]
} | {
"id": "C0024312",
"name": "lymphopenia",
"pos": [
118,
129
]
} |
the patient with unstable angina ( angina of recent onset , of changing pattern or occurring at rest ) is at high risk of myocardial infarction and sudden death . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
17,
32
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
35,
41
]
} |
the mortality in the same period is less than 2 % ( as compared with 17 % before 1970 ) , though during the first year it is about 17 % , much higher than in patients with stable angina and in survivors of acute myocardial infarction.urgent aortocoronary bypass grafting has proven to be unnecessary and probably undesirable for most patients with unstable angina , and is now generally reserved for patients who continue to have angina in hospital while receiving full medical therapy . | NA | {
"id": "C0340288",
"name": "stable angina",
"pos": [
172,
185
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
430,
436
]
} |
the mortality in the same period is less than 2 % ( as compared with 17 % before 1970 ) , though during the first year it is about 17 % , much higher than in patients with stable angina and in survivors of acute myocardial infarction.urgent aortocoronary bypass grafting has proven to be unnecessary and probably undesirable for most patients with unstable angina , and is now generally reserved for patients who continue to have angina in hospital while receiving full medical therapy . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
348,
363
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
430,
436
]
} |
plasma conjugation studies of [ 14c ] putrescine and [ 14c ] spermidine in both groups indicated near-total conjugation of the radiolabel within 4 to 5 min of i.v . injection . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
38,
48
]
} | {
"id": "C0037871",
"name": "groups",
"pos": [
80,
86
]
} |
the attempt to synthesize a lipid a-like component ( the active portion of lipopolysaccharides , but lacking its endotoxic activity ) resulted in the production of fatty acyl sugars of which maltose tetrapalmitate was seen to yield the most promising results . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
28,
35
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
75,
94
]
} |
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