text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the method has been applied to the analysis of retinoid levels in the liver and intestine of vitamin a-deficient hamsters following a p.o . dose ( 0.5 mg/day for 2 days ) of retinyl acetate or of a synthetic vitamin a analog and is predictive of the degree to which various synthetic retinoids can be converted to retinol and stored in the liver as retinyl esters . | NA | {
"id": "C0073109",
"name": "retinyl acetate",
"pos": [
174,
189
]
} | {
"id": "C0042839",
"name": "a",
"pos": [
346,
347
]
} |
the method has been applied to the analysis of retinoid levels in the liver and intestine of vitamin a-deficient hamsters following a p.o . dose ( 0.5 mg/day for 2 days ) of retinyl acetate or of a synthetic vitamin a analog and is predictive of the degree to which various synthetic retinoids can be converted to retinol and stored in the liver as retinyl esters . | NA | {
"id": "C0042839",
"name": "a",
"pos": [
12,
13
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
284,
293
]
} |
for ascites tumors , maximum increases in lifespan ( using 6 -- 12 mg/kg q2d x 5 ) with 10-deaza-aminopterin versus methotrexate were + 171.2 % /+ 149.8 % against l1210 leukemia , +118.4 % /+109.1 % against p815 plasmacytoma , +64 % /+20.9 % against ehrlich ascites carcinoma , +84.2 % /+44.8 % against taper liver tumor , and greater than +159.6 % /+64.0 % against sarcoma 180 with longterm survivors after 10-deaza-aminopterin . | NA | {
"id": "C0007125",
"name": "ascites tumors",
"pos": [
4,
18
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
266,
275
]
} |
in a smaller number of experiments comparing ld10 dosages ( given q2d x 5 ) of aminopterin , methotrexate , and 10-deaza-aminopterin , aminopterin was the least effective and 10-deaza-aminopterin was the most effective against the l1210 leukemia , sarcoma 180 , and ehrlich ascites tumors . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
93,
105
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
184,
195
]
} |
influence of sucrose concentration on production of organic acids , soluble polysaccharides and reducing sugars in human dental plaque in vitro . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
13,
20
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
105,
111
]
} |
the im cells were classified into two subgroups , according to the proportions of adrenaline type granules and noradrenaline type granules . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
82,
92
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
111,
124
]
} |
in these rel- cells , the effect of amino acid starvation on the rates of synthesis of complete individual proteins is both protein- and amino acid-specific . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
74,
83
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
124,
131
]
} |
we find that gs/gs cef contain approximately 100 copies of viral rna per cell , gs/gs cef contain no detectable viral rna , and the heterozygote gs/gs cef contain approximately 50 copies of viral specific rna per cell . | NA | {
"id": "C0016030",
"name": "cef",
"pos": [
19,
22
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
213,
217
]
} |
evaluation of the more abundant nonpolyadenylated nuclear rna molecules showed that they have the same 5 ' ends as the poly ( a ) -containing nuclear rnas . | NA | {
"id": "C0035668",
"name": "nonpolyadenylated",
"pos": [
32,
49
]
} | {
"id": "C0035700",
"name": "nuclear rnas",
"pos": [
142,
154
]
} |
[ steroidal sapogenins . i. determination of hecagenins and tigogenins in agave sisalana perrine using gas chromatography ] . | NA | {
"id": "C0038317",
"name": "steroidal",
"pos": [
2,
11
]
} | {
"id": "C0036188",
"name": "sapogenins",
"pos": [
12,
22
]
} |
post-lipolysis very low density lipoprotein was prepared in vitro after incubation of the intact lipoprotein with either purified bovine milk lipoprotein lipase or lipoprotein lipase rich ( post-heparin ) plasma . | NA | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
15,
43
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
164,
175
]
} |
this article gives the decisions of the who nomenclature committee on leukocyte antigens , in particular concerning ( a ) the upgrading of certain hla-a and hla-b specificities to full hla status , ( b ) the designation of new provisional specificities of the hla-b , hla-c , and hla-d loci , and ( c ) the establishment of a nomenclature for the new specificities identified by serological techniques on b lymphocytes . | NA | {
"id": "C0019721",
"name": "leukocyte",
"pos": [
70,
79
]
} | {
"id": "C0019737",
"name": "hla-b",
"pos": [
260,
265
]
} |
this article gives the decisions of the who nomenclature committee on leukocyte antigens , in particular concerning ( a ) the upgrading of certain hla-a and hla-b specificities to full hla status , ( b ) the designation of new provisional specificities of the hla-b , hla-c , and hla-d loci , and ( c ) the establishment of a nomenclature for the new specificities identified by serological techniques on b lymphocytes . | NA | {
"id": "C0019721",
"name": "leukocyte",
"pos": [
70,
79
]
} | {
"id": "C0019751",
"name": "hla-c",
"pos": [
268,
273
]
} |
under well defined conditions ribosomal rnas purified from escherichia coli can be degraded by ribonuclease u2 giving rise to rna fragments of 60 -- 70 nucleotides . | NA | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
30,
44
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
126,
129
]
} |
analysis of the creatinine , 17-oxosteroids , 17-oxogenicsteroids , estrogens , pregnanediol , androsterone + etiocholanolone and estriol in urine samples acidified to ph 2-3 with hcl , and in the same samples acidified with buffer , gave results which were indistinguishable from each other . | NA | {
"id": "C0000167",
"name": "17-oxosteroids",
"pos": [
29,
43
]
} | {
"id": "C0002865",
"name": "androsterone",
"pos": [
95,
107
]
} |
analysis of the creatinine , 17-oxosteroids , 17-oxogenicsteroids , estrogens , pregnanediol , androsterone + etiocholanolone and estriol in urine samples acidified to ph 2-3 with hcl , and in the same samples acidified with buffer , gave results which were indistinguishable from each other . | NA | {
"id": "C0000167",
"name": "17-oxosteroids",
"pos": [
29,
43
]
} | {
"id": "C0015124",
"name": "etiocholanolone",
"pos": [
110,
125
]
} |
aliquots of diluted urine were incubated at room temperature for 1 h with 125i-labeled albumin and a rabbit antiserum monospecific for human albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
87,
94
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
135,
148
]
} |
we also describe the relations between high- or low-density lipoprotein cholesterol and total cholesterol , and between cholesterol concentrations in these two lipoprotein classes . | NA | {
"id": "C0023824",
"name": "low-density lipoprotein",
"pos": [
48,
71
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
120,
131
]
} |
we describe an isothermal gas-liquid chromatographic procedure developed for measuring procaine and chloroprocaine in plasma . | NA | {
"id": "C0033218",
"name": "procaine",
"pos": [
87,
95
]
} | {
"id": "C0055443",
"name": "plasma",
"pos": [
118,
124
]
} |
the artifact binds to albumin , is not a protein , and occurs in some normal sera at very low concentrations . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
22,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
41,
48
]
} |
hepatocyte injury reduces the capacity of this major storage site and causes release of vitamins ( co-enzymes ) into the circulation in the form of holoenzymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
102,
109
]
} | {
"id": "C0282109",
"name": "holoenzymes",
"pos": [
148,
159
]
} |
the precipitation apparently depends on the ionic radii of the cations used as well as on the lipoprotein class tested . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
44,
49
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
63,
70
]
} |
the mean lymph/serum ratio for complement proteins was : for c1q 0.048 , for c1s 0.06 , for c4 0.199 , for c3 0.225 , for c9 0.244 and for c3pa 0.263 . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
31,
41
]
} | {
"id": "C0033453",
"name": "c3pa",
"pos": [
139,
143
]
} |
supressor cells were generated by pre-incubation of peripheral blood mononuclear cells with a mitogenic concentration of con a , followed by treatment with mitomycin c and alpha-methyl mannoside . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
} | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
52,
68
]
} |
our data emphasize that antiarrhythmic drug effectiveness be evaluated in terms of effect on sustained arrhythmia rather than suppression of isolated ectopic beats . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
103,
113
]
} | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
150,
163
]
} |
the onset of periodontal disease was early , with 60 % of the children in the 6-7 year group having gingivitis . | NA | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
13,
32
]
} | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
100,
110
]
} |
immunoglobulin levels and igg and iga antibodies to epstein-barr virus ( ebv ) , viral capsid antigens ( vca ) and early antigens ( ea ) were tested in 67 untreated ( 5 stage i , 32 stage ii , 16 stage iii and 14 stage iv ) , 21 treated and 7 recurrent nasopharyngeal carcinoma ( npc ) patients and 54 normal subjects . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
81,
86
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
121,
129
]
} |
igg and iga levels , anti-vca titers in igg and iga , and anti-ea titers in igg increased with advances of the disease in untreated npc patients . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
26,
29
]
} | {
"id": "C0003320",
"name": "ea",
"pos": [
126,
128
]
} |
untreated patients had higher anti-vca titers in igg , and anti-ea titers in igg and iga than 60co-treated cases , but lower than recurrent patients . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
35,
38
]
} | {
"id": "C0003320",
"name": "ea",
"pos": [
101,
103
]
} |
anti-vca in iga and igg was more closely correlated than anti-ea in iga and igg . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
5,
8
]
} | {
"id": "C0003320",
"name": "ea",
"pos": [
62,
64
]
} |
fractionation of total adult dna of five of the seven species of the melanogaster species sub-group of drosophila in actinomycin d and distamycin a caesium density gradients has revealed the presence of three main-band dna components , common to all species , and ten satellite dnas that are distributed between the species . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
29,
32
]
} | {
"id": "C0012934",
"name": "satellite dnas",
"pos": [
268,
282
]
} |
the aminosugar moiety of daunomycin , daunosamine , increases the binding of daunomycin to dna and also enhances chromosome banding. -- nogalamycin , which displays no differential quenching with the different dnas in solution , also fails to produce bands on chromosomes. -- these findings suggest that non-random nucleotide sequence arrangements along the chromosome are a basic determinant for dye interaction to produce the observed banding patterns . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
25,
35
]
} | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
136,
147
]
} |
phenylacetone , phenyl-2-butanone , and 3-methyl-1-phenyl-2-butanone were incubated with rabbit liver 9000g supernatant fraction for 30 and 60 min to yield primarily the alcohols , plus small amounts of 1,2-glycols and ketols ( 2-one-1-ols ) . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
170,
178
]
} | {
"id": "C0017951",
"name": "glycols",
"pos": [
207,
214
]
} |
systolic blood pressure , heart rate and concentrations of adrenaline , noradrenaline and dopamine as well as plasma dopamine-beta-hydroxylase ( dbh ) were measured in 22 subjects in recumbency and on standing up . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
59,
69
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
72,
85
]
} |
[ regulation of the adenohypophysis by hypothalamic hormones . biochemistry and physiology of releasing hormones . iii . corticotropin releasing hormone , prolactin releasing hormone , prolactostatin , melanotropin releasing hormone , melanostatin ] . | NA | {
"id": "C0020656",
"name": "hypothalamic hormones",
"pos": [
39,
60
]
} | {
"id": "C0033374",
"name": "prolactin releasing hormone",
"pos": [
155,
182
]
} |
the steroidal estrogens ethinylestradiol , mestranol and the synthetic `` '' impeded '' '' estrogen derivatives sts 456 , sts 593 and j 628 were studied for their postcoital antifertility activity and estrogenicity in mice , rats and rabbits . | NA | {
"id": "C0015011",
"name": "ethinylestradiol",
"pos": [
24,
40
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
43,
52
]
} |
at post-mortem both a cranial mesenteric arteritis and the congenital cardiac anomaly , tetralogy of fallot were found . | NA | {
"id": "C0018798",
"name": "congenital cardiac anomaly",
"pos": [
59,
85
]
} | {
"id": "C0039685",
"name": "tetralogy of",
"pos": [
88,
100
]
} |
if unlabeled gdp-mannose was also present , the 14c label appeared in the trisaccharide and higher oligosaccharide lipids . | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
74,
87
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
99,
114
]
} |
in addition to studying the spin-state transition in aquomethemoglobin we have also studied it in complexes of the heme group in methemoglobin with fluoride , azide and cyanide anions . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
169,
176
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
177,
183
]
} |
chromatographical analysis showed that concentrations of noradrenaline as well as of adrenaline rose during treatment with propranolol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
57,
70
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
85,
95
]
} |
furthermore , the urinary excretion of noradrenaline , adrenaline and 4-hydroxy-3-methoxy mandelic acid did not change during beta receptor blockade . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} |
their reactivity against mhc-different testis cells or mhc-compatible nontesticular fibroblasts was significantly decreased which suggests both tissue as well as mhc specificity of the eao response . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
84,
95
]
} |
the increase in naloxone ed50 was much more pronounced when naltrexone was given prior to and during the course of pellet implantation . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
16,
24
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
60,
70
]
} |
absorption of cefadroxil is unaffected by food , its serum levels are prolonged and it is excreted in the urine at a relatively slow rate compared to cephalexin . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
14,
24
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
150,
160
]
} |
studies on the subpopulation and function of peripheral lymphocytes , and lymphocyte reactivity to colonic mucosal antigen and bacterial antigen in patients with ulcerative colitis and crohn 's disease . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
115,
122
]
} | {
"id": "C0003321",
"name": "bacterial antigen",
"pos": [
127,
144
]
} |
however , when the disease entered remission , the immunological conditions settled down and the pathological condition appeared stable . | NA | {
"id": "C0012634",
"name": "disease",
"pos": [
19,
26
]
} | {
"id": "C0030660",
"name": "pathological condition",
"pos": [
97,
119
]
} |
the rate of structural chromosome mutations at the second k-mitosis was studied in the primary culture of embryonic fibroblasts from balb mice , after treating these cells with uv-rays at various wavelength during g2-phase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
116,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
166,
171
]
} |
a dna fragment of 463 base pairs has been isolated by hpaii digestion of the ecori cleaved lambdabiot124-10 dna fragment containing the escherichia coli biotin gene cluster . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
108,
111
]
} |
as little as 10 ( 2 ) lethal units of purified colicin e3 per cell exert a pronounced cytocidal effect on human epithelial hela cells and as little as 10 ( 4 ) lethal units per cell also on line l mouse fibroblasts in tissue culture . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
62,
66
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
203,
214
]
} |
the demonstartion of collagen can be performed easily in histology laboratories using formalin-fixed cells , and provides a means of assaying a functional property of cells in culture which is characteristic of connective tissue fibroblasts in general as well as certain specialized epithelia . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
229,
240
]
} |
addition of pure h2o2 and use of the enzyme catalase demonstrate that about 40 % of the toxicity in irradiated medium is due to generated peroxide . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
17,
21
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
138,
146
]
} |
shifts in adenine nucleotide levels upon the addition of nadh to cell-free extracts were impossible to evaluate due to the presence of nad ( + ) nucleosidase . | NA | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
10,
28
]
} | {
"id": "C0027270",
"name": "nadh",
"pos": [
57,
61
]
} |
the accreted proteins were found to be host albumin , immunoglobulin g ( igg ) , and complement ( c3 ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
13,
21
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
44,
51
]
} |
cfa/i and cfa/ii were never found on the same serotypes of etec , but 98 % of the heat-stable and heat-labile enterotoxin-producing etec belonging to the frequently isolated serogroups o6 , o8 , o15 , o25 , o63 , and o78 were positive for either cfa/i or cfa/ii . | NA | {
"id": "C0003320",
"name": "cfa/i",
"pos": [
0,
5
]
} | {
"id": "C0003316",
"name": "cfa/i",
"pos": [
255,
260
]
} |
the aminoglycosides of the kanamycin and neomycin series are displaced from their protein binding by very low ca++ ion concentrations , whereas streptomycin is displaced only by very high ca++ ion concentrations . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
4,
19
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
144,
156
]
} |
two hours after the administration the renal tissue concentrations ranged in patients with hydronephrotic kidneys from 38.0-63.5 microgram/g , in patients with cirrhotic kidneys from 17.9-42.7 microgram/g , in patients with pyonephrosis from 9.8-17.6 microgram/g and in patients with renal carcinoma from 37.7-64.2 microgram/g . | NA | {
"id": "C0020295",
"name": "hydronephrotic",
"pos": [
91,
105
]
} | {
"id": "C0034216",
"name": "pyonephrosis",
"pos": [
224,
236
]
} |
the highest renal tissue/serum concentration ratios of thiamphenicol were observed in patients with hydronephrotic kidneys and renal tumours , the lowest in cases of pyonephrosis . | NA | {
"id": "C0020295",
"name": "hydronephrotic",
"pos": [
100,
114
]
} | {
"id": "C0034216",
"name": "pyonephrosis",
"pos": [
166,
178
]
} |
coconut charcoal is not effective in removing galactose , whereas petroleum-based activated charcoal is very effective . | NA | {
"id": "C0007955",
"name": "charcoal",
"pos": [
8,
16
]
} | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
82,
100
]
} |
urinary excretion and tissue content of vitamin b1 in rats treated with thiamine chloride ester monophosphate of bis-glucosamine . | NA | {
"id": "C0039840",
"name": "vitamin b1",
"pos": [
40,
50
]
} | {
"id": "C0039845",
"name": "thiamine",
"pos": [
72,
80
]
} |
research has been carried out on the metabolism of thiamine chloride ester monophosphate of bis-d-glucosamine ( tcmpg ) evaluating the urinary excretion , the blood and the hepatic content of thiamine in the rat after intraperitoneal injection of this compound . | NA | {
"id": "C0039845",
"name": "thiamine",
"pos": [
51,
59
]
} | {
"id": "C0039840",
"name": "thiamine",
"pos": [
192,
200
]
} |
in fact , the amount of thiamine excreted by the rats which have received the tcmpg is lower while the blood and liver levels of vitamin are higher , compared with the control rats treated with thiamine monophosphate only , or with thiamine and glucosamine . | NA | {
"id": "C0039845",
"name": "thiamine monophosphate",
"pos": [
194,
216
]
} | {
"id": "C0039840",
"name": "thiamine",
"pos": [
232,
240
]
} |
ascorbic acid appears to play a role in a number of neutrophil functions including increased chemotaxis , increased particulate ingestion , enhanced lysozyme-mediated non-oxidative killing , protection against the toxic effects of superoxide anion radical , inhibition of the halide-peroxide-myeloperoxidase system without a pronounced bactericidal effect , and stimulation of the hexose monophosphate shunt . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
231,
241
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
283,
291
]
} |
the acetylcarnitine/carnitine ratio has been found significantly increased in tibial muscles of swimming rats in comparison with normal rats . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
4,
19
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
20,
29
]
} |
swimming also induced a statistically significant increase of the acetylcarnitine/carnitine ratio in heart , while norepinephrine administration resulted in a decrease of carnitine not accompanied by a corresponding increase in acetylcarnitine in a severe carnitine depletion of cardiac muscle . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
66,
81
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
256,
265
]
} |
a case of contact sensitization to lead is described which presented as an acute bullous contact dermatitis after application of an ointment containing lead oxide ( unguentum diachylon hebra ) . | NA | {
"id": "C0023175",
"name": "lead",
"pos": [
35,
39
]
} | {
"id": "C0064720",
"name": "lead",
"pos": [
152,
156
]
} |
documentation in the literature indicates that death is as painless following the induction of hypoxia by rapid decompression as by other methods that lead to hypoxia , such as exposure to high altitude , carbon monoxide , and inert gases ( nitrogen , xenon , and krypton ) . | NA | {
"id": "C0017112",
"name": "inert gases",
"pos": [
227,
238
]
} | {
"id": "C0043339",
"name": "xenon",
"pos": [
252,
257
]
} |
documentation in the literature indicates that death is as painless following the induction of hypoxia by rapid decompression as by other methods that lead to hypoxia , such as exposure to high altitude , carbon monoxide , and inert gases ( nitrogen , xenon , and krypton ) . | NA | {
"id": "C0017112",
"name": "inert gases",
"pos": [
227,
238
]
} | {
"id": "C0022792",
"name": "krypton",
"pos": [
264,
271
]
} |
on examining the structure of the antibiotic tridecaptin a , the constituent amino acids were determined to be : 2,4-diaminobutyric acid ( 2d , 1l ) , ser ( 1d , 1l ) , glu ( 1l ) , gly ( 1 ) , ala ( 1l ) , val ( 1d , 1l ) , aile ( 1d ) , phe ( 1l ) and trp ( 1d ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
77,
88
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
182,
185
]
} |
the syntheses of 1-n- ( s-4-amino-2-hydroxybutyryl ) -gentamicin b and 1-n- ( s-3-amino-2-hydroxypropionyl ) -gentamicin b , designated sch 20287 and sch 21420 , respectively , by procedures similar to those developed by kawaguchi and co-workers for the transformation of kanamycin a to amikacin are described . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
272,
281
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
287,
295
]
} |
the two predominant porphyrins produced were identified , on the basis of their spectrophotometric and chromatographic properties , as protoporphyrin and coproporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
20,
30
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
135,
149
]
} |
the two predominant porphyrins produced were identified , on the basis of their spectrophotometric and chromatographic properties , as protoporphyrin and coproporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
20,
30
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
154,
168
]
} |
although density ultracentrifugation revealed the presence of traces of a high-density lipoprotein in bovine serum fraction , another , less dense component , isolated by ultracentrifugation ( component 3 ) and containing cholesterol , cholesteryl esters , free fatty acids , triglycerides , and protein , but no lipoprotein , exhibited considerably more growth-supporting activity than did the high-density lipoprotein , thus indicating that at least two mycoplasma species do not require intact serum lipoprotein for growth . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
222,
233
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
236,
254
]
} |
strains of p. avidum would consistently grow to a transmittance of 1 to 3 % at 560 nm in a basal salts medium supplemented with glucose , pantothenate , biotin , thiamine , and 12 amino acids ( alanine , arginine , cysteine , glutamine , glycine , histidine , isoleucine , methionine , phenylalanine , serine , tyrosine , and tryptophan ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
180,
191
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
292,
299
]
} |
strains of p. avidum would consistently grow to a transmittance of 1 to 3 % at 560 nm in a basal salts medium supplemented with glucose , pantothenate , biotin , thiamine , and 12 amino acids ( alanine , arginine , cysteine , glutamine , glycine , histidine , isoleucine , methionine , phenylalanine , serine , tyrosine , and tryptophan ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
180,
191
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
238,
245
]
} |
other nutrients which were not absolute requirements , but which significantly improved growth of these species , included the purines guanine and/or adenine , tween 80 , which served as a source of oleic acid , sodium l-lactate , alpha-ketoglutarate , and pyruvate . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
127,
134
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
150,
157
]
} |
metabolic activity was detected by monitoring levels of reduced glutathione ( gsh ) , oxidized glutathione ( gssg ) , and the soluble-amino acid pools as a function of incubation time . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
78,
81
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
109,
113
]
} |
wet conidia ( approximately 65 % water content ) exhibited significant metabolic activity as evidenced by : ( i ) reduction of gssg to gsh , ( ii ) degradation of gsh , and ( iii ) changes in the pool sizes of certain amino acids . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
127,
131
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
163,
166
]
} |
interactions can arise from changes in absorption , protein binding , metabolism , excretion or activity at a common site of action . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
70,
80
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
83,
92
]
} |
a cyclic nucleotide-independent protein kinase , which was produced from its proenzyme upon limited proteolysis by a ca2+-dependent protease ( takai , y. , yamamoto , m. , inoue , m. , kishimoto , a. , & nishizuka , y . ( 1977 ) biochem . biophys . res . commun . 77 , 542-550 ) , showed an ability to phosphorylate not only muscle glycogen phosphorylase kinase but also glycogen synthase , resulting in activation and inactivation of the respective enzymes , although the protein kinase was less active than adenosine 3':5'-monophosphate ( cyclic amp ) -dependent protein kinase toward glycogen synthase . | NA | {
"id": "C0031713",
"name": "muscle",
"pos": [
325,
331
]
} | {
"id": "C0033640",
"name": "protein",
"pos": [
565,
572
]
} |
a precursor spore coat protein with a molecular weight of 25,000 is made initially at t1 of sporulation and is converted to the mature spore coat protein with a molecular weight of 13,500 at t2 - t3 . | NA | {
"id": "C0033665",
"name": "precursor",
"pos": [
2,
11
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
146,
153
]
} |
the binary complex of enzyme with nadh is only partially stable to exhaustive dialysis and gel electrophoresis , where it shows greater mobility ( 0.26 ) than the free enzyme ( 0.21 ) ; | NA | {
"id": "C0026741",
"name": "complex",
"pos": [
11,
18
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
168,
174
]
} |
incubations of the microsomal preparations with both udp- [ 14c ] -glcua and udp-galn [ 3h ] ac together resulted in formation of [ 14c,3h ] chondroitin chains added to the endogenous chondroitin sulfate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
141,
152
]
} | {
"id": "C0008466",
"name": "chondroitin sulfate",
"pos": [
184,
203
]
} |
the role of atp and divalent cations in the regulation of a cardiac phosphorylase phosphatase ( phosphoprotein phosphatase ) of mr = 35,000 . | NA | {
"id": "C0031714",
"name": "phosphorylase phosphatase",
"pos": [
68,
93
]
} | {
"id": "C0031686",
"name": "phosphoprotein phosphatase",
"pos": [
96,
122
]
} |
related coagulation factors , including factor x , factor ixa , diisopropylphosphoryl factor xa , and prothrombin do not complete with factor xa for the xa binding sites . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
8,
27
]
} | {
"id": "C0015518",
"name": "factor",
"pos": [
135,
141
]
} |
related coagulation factors , including factor x , factor ixa , diisopropylphosphoryl factor xa , and prothrombin do not complete with factor xa for the xa binding sites . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
8,
27
]
} | {
"id": "C0033706",
"name": "prothrombin",
"pos": [
102,
113
]
} |
related coagulation factors , including factor x , factor ixa , diisopropylphosphoryl factor xa , and prothrombin do not complete with factor xa for the xa binding sites . | NA | {
"id": "C0015518",
"name": "factor",
"pos": [
20,
26
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
135,
144
]
} |
stimulation of the alpha-receptor with norepinephrine , epinephrine , or phenylephrine in the presence of 20 micrometer propranolol caused an increase in the phosphorylation of at least 10 of the same 12 phosphorylated bands stimulated by glucagon . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
39,
53
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} |
the protein-phosphate bond behaves like a phospho-ester , and labeled phospho-serine is identified in an acid hydrolysate of the protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0033631",
"name": "hydrolysate",
"pos": [
110,
121
]
} |
the disruption of neurofilaments during this interval occurred in parallel with a selective loss of 69,000 , 150,000 and 200,000 mol wt proteins from nerve homogenates , thus corroborating the view that these proteins represent component subunits of mammalian neurofilaments . | NA | {
"id": "C0027759",
"name": "proteins",
"pos": [
136,
144
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
209,
217
]
} |
the intracellular transport of venom proteins has been studied in active and resting venom glands of the snake vipera palaestinae by electron microscope radioautography after an intra-arterial injection of [ 3h ] leucine . | NA | {
"id": "C0042479",
"name": "venom",
"pos": [
31,
36
]
} | {
"id": "C0037380",
"name": "venom",
"pos": [
85,
90
]
} |
the major cell surface glycoprotein of chick embryo fibroblasts , cellular fibronectin ( formerly known as csp or lets protein ) , was purified and used to produce monospecific antisera . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
52,
63
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
66,
74
]
} |
treatment of untransformed chick fibroblasts with anti-fibronectin results in rapid ( 30 min ) alteration to a rounder cell shape resembling that of many transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
166,
171
]
} |
when tissue sections are extracted with 0.1 n hcl , cellular nuclear proteins , including histones , are removed but nuclear dna is retained . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
61,
77
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
90,
98
]
} |
the maximal capacity of added amino acids such as aspartate , cysteine , leucine , and valine to stimulate net alanine and glutamine formation was the same in uremic and control muscle . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
30,
41
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
111,
118
]
} |
the regulation of skeletal muscle alanine and glutamine formation and release in experimental chronic uremia in the rat : subsensitivity of adenylate cyclase and amino acid release to epinephrine and serotonin . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
34,
41
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
162,
172
]
} |
with control muscles , 1 nm or greater , epinephrine inhibited alanine and glutamine release , whereas with uremic muscles , epinephrine concentrations < 1 mum did not alter amino acid release . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
63,
70
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
174,
184
]
} |
inhibition of na ( + ) k ( + ) atpase at either na : k ratio by ouabain , an activator of secretion , and enhancement of the high-ratio na ( + ) k ( + ) atpase by diphenylhydantoin , an islet secretory inhibitor , were also common to both tissues . | NA | {
"id": "C0001479",
"name": "k",
"pos": [
23,
24
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
153,
159
]
} |
results showed that adrenaline and noradrenaline excretion decreased , while performance on cognitive tests was unaffected . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
20,
30
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
35,
48
]
} |
the histological appearance was of nodular , densely cellular tissue composed of histiocytes , plasma cells , lymphocytes , fibroblasts , and occasional polymorphonuclear cells . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
53,
61
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
124,
135
]
} |
hypertriglyceridaemia , absence of alpha and pre beta bands on the lipoprotein electrophoresis pattern , low level of apo a , and presence of abnormal lipoproteins ( beta-vldl and beta2-lp ) were observed in the early phase of acute hepatitis . | NA | {
"id": "C0023825",
"name": "pre beta",
"pos": [
45,
53
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
151,
163
]
} |
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