text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
infusion of saralasin , an aii antagonist , directly into the sfo selectively and reversibly antagonized intravenous aii drinking ( experiment 5 ) . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
12,
21
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
117,
120
]
} |
paraffin sections of mouse adrenals processed with antiserum to luteinizing hormone-releasing hormone ( lhrh ) in the unlabeled antibody enzyme method reveal moderate staining in the cytoplasm of cells of zona fasciculata and reticularis . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
51,
60
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
128,
136
]
} |
the interaction between idiotypic antibody and anti-idiotypic antiserum was specifically inhibited by gat and the closely related polymer of l-glutamic acid and l-tyrosine ( gt ) but not by the copolymer of l-glutamic acid and l-alanine ( ga ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
34,
42
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
62,
71
]
} |
plaque forming cells ( pfc ) were also detected against syngeneic and allogeneic lymph node cells and to a much lesser extent against splenocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
15,
20
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
70,
80
]
} |
sera , igg preparations , and antibody fractions containing these allotypes inhibited the binding of insolubilized allotypic antisera to various radiolabeled antigens including igg pools , homogeneous antibodies , and , in the case of a3 , a vh fragment from a3/b4 igg . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
125,
133
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
201,
211
]
} |
in any case , these results suggest the possibility that lymphokines other than lymphotoxin or macrophage-activating factors may play a role in tumor immunity . | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
57,
68
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
80,
91
]
} |
in any case , these results suggest the possibility that lymphokines other than lymphotoxin or macrophage-activating factors may play a role in tumor immunity . | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
57,
68
]
} | {
"id": "C0079786",
"name": "macrophage-activating",
"pos": [
95,
116
]
} |
these studies provide the first evidence that changing the physicochemical parameters of preformed immune complexes by simply altering the ratio of antigen to antibody can dramatically alter the phlogistic properties of immune complexes for pulmonary tissue . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
159,
167
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
220,
236
]
} |
some ( h-2b , k , s ) insulin-nonresponder mice produce insulin-binding antibodies after injection of proinsulin , whereas other insulin-nonresponder strains ( h-2q ) do not . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
102,
112
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
129,
136
]
} |
more importantly , f1 hybrids between insulin-nonresponder c57bl/10 ( h-2b ) and dba/1 ( h-2q ) produce no insulin-binding antibodies when injected with proinsulin , despite the fact that proinsulin-binding antibodies are produced by these mice . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
38,
45
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
188,
198
]
} |
more importantly , f1 hybrids between insulin-nonresponder c57bl/10 ( h-2b ) and dba/1 ( h-2q ) produce no insulin-binding antibodies when injected with proinsulin , despite the fact that proinsulin-binding antibodies are produced by these mice . | NA | {
"id": "C0021644",
"name": "insulin",
"pos": [
38,
45
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
207,
217
]
} |
the enriched particles , prepared from cholesterol-containing lipid dispersions , passed into the duodenum , had four to ten times the cholesteryl ester content of the control chylomicrons but had the same content of total `` '' core '' '' ( cholesteryl ester + triglyceride ) lipid . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
39,
50
]
} | {
"id": "C0008387",
"name": "( cholesteryl est",
"pos": [
240,
257
]
} |
among the proteins of intermediate molecular weight , apoproteins a-i and the arginine-rich apoprotein accounted for 31 % and 4 % of the total protein mass , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
10,
18
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
92,
102
]
} |
apoprotein a-i also accounted for more than 30 % of the protein mass of mesenteric lymph lipoproteins of density less than 1.006 g/ml ( `` '' small chylomicrons '' '' ) obtained from rats fed glucose . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
89,
101
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
148,
159
]
} |
the fractional content of apoprotein a-i in the protein of chylomicrons fell after incubation , whereas that of the arginine-rich apoprotein remained constant or rose substantially . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
29,
36
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
130,
140
]
} |
electrophoretic analyses of the extracted proteins in polyacrylamide gel gradients containing sds gave patterns that were very similar to those obtained by direct analysis of sds disrupted viruses . | NA | {
"id": "C0037506",
"name": "sds",
"pos": [
94,
97
]
} | {
"id": "C0058632",
"name": "sds",
"pos": [
175,
178
]
} |
experiments using antiserum to hsv-1 or hsv-2 , absorbed with appropriate hemotypic or heterotypic antigens , revealed that both type-specific ( homotypic ) and cross-reactive antibody combined with surface glycoproteins to form a single large radioactive peak . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
18,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
176,
184
]
} |
early antigen development occurs in the presence of dna , rna , and protein synthesis inhibitors and is dependent on intact viral dna in the inoculum . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
52,
55
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
124,
133
]
} |
human cmv antigens could not be detected and virus could not be rescued from these cells by co-cultivation with fully permissive human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
83,
88
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
135,
146
]
} |
network analysis also supported the suggestion that a stable association between the virus dna and host dna begins shortly after infection . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
104,
107
]
} |
a nucleic acid fraction consisting of rna and dna sequences with an apparent mol . wt . of 1.4 to 1.5 x 10 ( 6 ) is present in minor amounts in purified influenza virus . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
2,
14
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} |
this acute manifestation is not likely to be a simple consequence of reduced dopaminergic activity , because it was never reported to occur following the use of drugs which deplete dopamine stores , like reserpine and tetrabenazine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
77,
89
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
181,
189
]
} |
they appear to be variants of medulloblastoma and not pigmented neuroectodermal tumors of infancy ( melanotic prognomas or retinal anlage tumors ) . | NA | {
"id": "C0206093",
"name": "neuroectodermal tumors",
"pos": [
64,
86
]
} | {
"id": "C0206094",
"name": "retinal anlage tumors",
"pos": [
123,
144
]
} |
the specific activity of the membrane-bound enzyme , na+-k+-activated adenosine triphosphatase ( atpase ) , has been shown to be decreased following experimental impact injury ( 400 gm-cm ) to the spinal cord in dogs . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
53,
55
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
97,
103
]
} |
the effect of protein deprivation on the plasma eaa concentration was also larger with egg protein than with rice protein , and the total eaa concentration of men fed egg protein changed significantly and in parallel with the n intake over the range of 44 to 99mg/kg . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0013700",
"name": "egg protein",
"pos": [
167,
178
]
} |
the concentration of plasma proteins and especially albumin decreased significantly during the period of consuming the low-protein diet . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
28,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
52,
59
]
} |
standard growth curves for achondroplasia , the most common form of short-limbed dwarfism , have been constructed based on measurements of height , growth velocity , upper and lower segment , and head circumference in 400 achondroplastic dwarfs . | NA | {
"id": "C0013336",
"name": "dwarfism",
"pos": [
81,
89
]
} | {
"id": "C0001080",
"name": "achondroplastic",
"pos": [
222,
237
]
} |
methods are described for the preparation of pure crystalline samples of the penicilloic and penilloic acids of penicillin g , carbenicillin , cloxacillin , floxacillin , methicillin , penicillin v , and ticarcillin and the penicilloic acids of amoxicillin , ampicillin , phenethicillin , and propicillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
112,
124
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
127,
140
]
} |
methods are described for the preparation of pure crystalline samples of the penicilloic and penilloic acids of penicillin g , carbenicillin , cloxacillin , floxacillin , methicillin , penicillin v , and ticarcillin and the penicilloic acids of amoxicillin , ampicillin , phenethicillin , and propicillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
112,
124
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
259,
269
]
} |
methods are described for the preparation of pure crystalline samples of the penicilloic and penilloic acids of penicillin g , carbenicillin , cloxacillin , floxacillin , methicillin , penicillin v , and ticarcillin and the penicilloic acids of amoxicillin , ampicillin , phenethicillin , and propicillin . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
143,
154
]
} | {
"id": "C0016267",
"name": "floxacillin",
"pos": [
157,
168
]
} |
methods are described for the preparation of pure crystalline samples of the penicilloic and penilloic acids of penicillin g , carbenicillin , cloxacillin , floxacillin , methicillin , penicillin v , and ticarcillin and the penicilloic acids of amoxicillin , ampicillin , phenethicillin , and propicillin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
245,
256
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
259,
269
]
} |
procedures are reported for the formation of pertrimethylsilyl and pertrimethylsilyl methoxime derivatives of the aglycones of doxorubicin , daunorubicin , carminomycin , chromomycin a3 , and mithramycin . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
127,
138
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
141,
153
]
} |
procedures are reported for the formation of pertrimethylsilyl and pertrimethylsilyl methoxime derivatives of the aglycones of doxorubicin , daunorubicin , carminomycin , chromomycin a3 , and mithramycin . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
141,
153
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
156,
168
]
} |
paired ion high-pressure liquid chromatography was useful for separating intact catecholamines ( epinephrine , isoproterenol , levodopa , and methyldopa ) and phenylephrine from some of their decomposition products . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
80,
94
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
111,
124
]
} |
high-pressure liquid chromatographic procedures are described for clindamycin , clindamycin palmitate , and clindamycin phosphate as bulk drugs and in formulations . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
66,
77
]
} | {
"id": "C0055881",
"name": "clindamycin phosphate",
"pos": [
108,
129
]
} |
in kidneys perfused with the protein-free medium , the sensitivity of the renal vasculature to the vasoconstrictor drugs epinephrine and angiotensin ii was only 1/40 the level seen in those kidneys perfused with media containing serum or albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
29,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
238,
245
]
} |
the effects of the barbiturate anaesthetic pentobarbitone on the membrane properties and amino acid pharmacology of mammalian c.n.s . neurones grown in tissue culture were studied using intracellular recording coupled with bath application , extracellular ionophoresis , or focal diffusion . | NA | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
19,
30
]
} | {
"id": "C0030883",
"name": "pentobarbitone",
"pos": [
43,
57
]
} |
2,4-dinitrophenol ( 2,4-dnp ) ( 2 x 10 ( -4 ) m ) or substitution of o2 by n2 caused an 80 % reversible decrease of net fluid transport . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
4,
17
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
24,
27
]
} |
of six animals given access to both water and 1.8 % sodium chloride solutions , five drank some saline during maintenance and control periods and all responded with short-latency drinking of water to infusion of angiotensin ii at 0.35 mug/kg . min.4 . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
36,
41
]
} | {
"id": "C0599638",
"name": "drinking",
"pos": [
179,
187
]
} |
incubations for sperm capacitation and egg fertilization in different media containing the various hexoses showed that rat epididymal spermatozoa could be partly capacitated without hexose , that d-glucose , d-mannose or d-galactose but not d-fructose is effective for sperm capacitation and that only d-glucose and d-mannose supported penetration of eggs in vitro . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
99,
105
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
223,
232
]
} |
incubations for sperm capacitation and egg fertilization in different media containing the various hexoses showed that rat epididymal spermatozoa could be partly capacitated without hexose , that d-glucose , d-mannose or d-galactose but not d-fructose is effective for sperm capacitation and that only d-glucose and d-mannose supported penetration of eggs in vitro . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
99,
105
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
243,
251
]
} |
incubations for sperm capacitation and egg fertilization in different media containing the various hexoses showed that rat epididymal spermatozoa could be partly capacitated without hexose , that d-glucose , d-mannose or d-galactose but not d-fructose is effective for sperm capacitation and that only d-glucose and d-mannose supported penetration of eggs in vitro . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
99,
105
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
318,
325
]
} |
in addition to being excreted in urine unchanged , tolazamide was metabolized to 1- ( hexahydroazepin-1-yl ) -3-p- ( carboxyphenyl ) sulfonylurea ( 2 ) , p-toluenesulfonamide ( 3 ) , 1- ( hexahydroazepin-1-yl ) -3-p- ( hydroxymethylphenyl ) sulfonylurea ( 4 ) , 1- ( 4-hydroxyhexahydroazepin-1-yl ) -3-p-tolylsulfonylurea ( 5 ) and a labile , unidentified metabolite 6 by man . | NA | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
51,
61
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
309,
321
]
} |
active transport of phosphate in the toad bladder was also inhibited by an analog of cyclic amp ( dibutyryl cyclic amp ) and by other drugs ( pitressin and theophylline ) which increase toad bladder intracellular cyclic amp concentration . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
98,
118
]
} | {
"id": "C0001455",
"name": "cyclic",
"pos": [
213,
219
]
} |
while these kinetic parameters did not differ significantly from mitochondria of cells of nonmineralizing tissues , the respiratory characteristics of the chondrocyte organelles exhibited functional differences . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
155,
166
]
} |
although such antibodies have been demonstrated in tumor hosts , xenogeneic antitumor sera should provide larger yields of better-defined antitumor antibodies for therapeutic purposes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0003251",
"name": "antitumor antibodies",
"pos": [
138,
158
]
} |
during the initial 2 weeks in culture , mammary cells and contaminating fibroblast-like cells were responsive to polypeptide and steroid hormones and the percentage of proliferating mammary cells could be enhanced with insulin , prolactin , estradiol , progesterone , and hydrocortisone . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
72,
82
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
150,
153
]
} |
in this system , at a dose of 1 microgram/ml , the microtubule inhibitors colchicine , demecolcine , vincristine sulfate , vinblastine sulfate , or methyl [ 5- ( 2-thienylcarbonyl ) -1h-benzimidazol-1-yl ] -carbamate ( nocodazole ) totally inhibited malignant invasion . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
74,
84
]
} | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
87,
98
]
} |
moreover , when m-musv-immune spleen cells from mice inoculated with virus 14 days previously were stimulated by allogeneic moloney leukemia cells , a strong cytotoxic effect toward syngeneic and allogeneic tumor cells bearing m-musv taa was elicited . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
37,
42
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
196,
206
]
} |
during the first 8 h after infection , hsv has little effect on the rate of synthesis of ad-rna as determined by hybridization of nuclear rna samples , but , during the same period , hsv inhibits the accumulation of poly ( a ) -containing ad-rna in the cytoplasm . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
92,
95
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
130,
141
]
} |
it has been proposed by others that the 200s dna replicative intermediates are required for dna packaging , but our results showed that the 800s dna of dar does not have to be converted into the 200s form to undergo conversion to mature viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
45,
48
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
237,
246
]
} |
genome organization and sequence homology were studied by fingerprinting large rnase t1-resistant oligonucleotides and by cross-protecting homologous oligonucleotides against rnase a and t1 digestion with complementary dna prepared from each of the other viral rna . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
79,
87
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
175,
180
]
} |
rna displacement loop patterns in intact herpes simplex virus dna and herpes simplex virus dna restriction fragments indicate that viral rna associated with polyribosomes early after infection is transcribed from three major areas of the genome . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
131,
140
]
} |
the interference effect could be partially neutralized by an increase in the multiplicity of coinfecting sv40 or by an increase in the time interval between sv40 infection and ad coinfection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
162,
171
]
} | {
"id": "C0275524",
"name": "coinfection",
"pos": [
179,
190
]
} |
the rabbit virus rna-directed dna polymerase and p30 protein shared antigenic homologies with other mammalian type c oncornaviruses but appear to also possess unique antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
68,
77
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
166,
188
]
} |
a protein similar to that previously demonstrated on poliovirus rna and replicative intermediate rna ( vpg ) was found on all sizes of nascent viral rna molecules and on the polyuridylic acid isolated from negative-strand rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
143,
152
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
222,
225
]
} |
although both amp-pnp and gmp-pnp were used in place of atp and gtp by escherichia coli rna polymerase to transcribe vaccinia virus dna , only gmp-pnp was used by the transcriptase present within vaccinia virus cores . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
64,
67
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
143,
150
]
} |
concentrations of diazepam and its three pharmacologically active metabolites ( desmethyldiazepam , temazepam , and oxazepam ) were determined in multiple samples drawn during and after hospitalization . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
18,
26
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
80,
97
]
} |
the main components of decreased fatty acids in these subcellular fractions corresponded to those of free fatty acids accumulating in the ischemic brain . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
33,
44
]
} | {
"id": "C0015688",
"name": "free fatty",
"pos": [
101,
111
]
} |
both drugs increased p-nitroanisole demethylase activity strikingly and aniline hydroxylase activity moderately , but produced little change in aminopyrine demethylase activity . alpha-naphthoflavone , which is known to be a specific inhibitor of aryl hydrocarbon hydroxylase induced by polycyclic aromatic hydrocarbons , inhibited at low concentrations p-nitroanisole demethylase activity of rats previously treated with both drugs . | NA | {
"id": "C0003039",
"name": "aniline hydroxylase",
"pos": [
72,
91
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
247,
275
]
} |
peripheral atherosclerosis was treated in 178 patients : 90 were given pyridinol carbamate for 2 -- 4 months , 40 pentoxyphylline , 30 cetedil , and 18 received butalamine . in intermittent claudication pyridinol carbamate and trental proved most effective , cetedil ( straten ) was less effective . | NA | {
"id": "C0003850",
"name": "atherosclerosis",
"pos": [
11,
26
]
} | {
"id": "C0021775",
"name": "intermittent claudication",
"pos": [
177,
202
]
} |
24 h after the intravitreal injection of ascorbic acid 13 out of 16 free amino acids were decreased , only glutamicacid , glycine and alanine were increased . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
73,
84
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
122,
129
]
} |
24 h after the intravitreal injection of ascorbic acid 13 out of 16 free amino acids were decreased , only glutamicacid , glycine and alanine were increased . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
73,
84
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
134,
141
]
} |
the relationship between the plasma concentration of high-density-lipoprotein ( hdl ) -cholesterol , very-low-density-lipoprotein ( vldl ) -triglycerides , and low-density-lipoprotein ( ldl ) -cholesterol and the fractional removal rate ( k2 ) of an intravenously administered fat emulsion ( intralipid ) was investigated in 13 normo- and 34 hypertriglyceridaemics . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
87,
98
]
} | {
"id": "C0023824",
"name": "ldl",
"pos": [
186,
189
]
} |
following immersion the frequency of extrasystolic arrhythmias increased four-fold and more severe arrhythmias -- group and systemic extrasystoles -- developed as compared with control exposures . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
51,
62
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
133,
146
]
} |
[ myasthenia gravis ( 1 ) . experimental myasthenia gravis -- a tool for the study of the pathogenesis , diagnosis and treatment of myasthenia gravis ] . | NA | {
"id": "C0026896",
"name": "myasthenia gravis",
"pos": [
2,
19
]
} | {
"id": "C0752087",
"name": "experimental myasthenia gravis",
"pos": [
28,
58
]
} |
in a prospective , randomised , double-blind trial to determine if cephalothin plus an aminoglycoside is more nephrotoxic than methicillin plus an aminoglycoside , patients were assigned to one of four treatment groups : cephalothin and gentamicin ( c.g . ) , cephalothin and tobramycin ( c.t . ) , methicillin and gentamicin ( m.g . ) , or methicillin and tobramycin ( m.t . ) . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
87,
101
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
315,
325
]
} |
in such mice a small dose of lipopolysaccharide endotoxin produced a lethal hepatitis , with high serum-transaminase concentrations , glycogen depletion , and hypoglycaemia . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
29,
47
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
48,
57
]
} |
high concentrations of the drug ( 0.3 mm or more ) fail to affect ba2+-induced insulin secretion but inhibit glucose-stimulated proinsulin biosynthesis , 45ca net uptake and insulin release . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
128,
138
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
174,
181
]
} |
administration of mcn-3716 produced a remarkable lowering of the plasma glucose and the glycosuria of depancreatized dogs but did not result in complete normalization of glucose , especially the excursions of blood glucose following feeding . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
72,
79
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
209,
222
]
} |
in the reciprocal combination of native baa as the immunogen and modified baa as the eliciting antigen , the relationship of anti-baa responses to dh was examined . | NA | {
"id": "C0003320",
"name": "immunogen",
"pos": [
51,
60
]
} | {
"id": "C0003321",
"name": "baa",
"pos": [
130,
133
]
} |
studying 54 cases of coronary sudden death by using 100-300 slides in each case , the fuchsinophilic zones were evidenced in 46 per cent of the cases , aspects indicating the morphologic substrate of the sudden death with ectopic ventricular electrical activity centres . | NA | {
"id": "C0085298",
"name": "coronary sudden death",
"pos": [
21,
42
]
} | {
"id": "C0011071",
"name": "sudden death",
"pos": [
204,
216
]
} |
because mucosal immune defense is largely mediated by antibodies of the iga isotype , the finding that iga protease activity is linked specifically to the pathogenic neisseria suggests that the enzyme may be involved in the pathogenesis of neisserial infection . | NA | {
"id": "C0020835",
"name": "antibodies",
"pos": [
54,
64
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
76,
83
]
} |
the titre and immunoglobulin class of antibodies against candida albicans in serum from 60 non-pregnant women was determined . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
14,
34
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
38,
48
]
} |
the amino-acid composition of the faecal protein is , independently of the dietary protein given , relatively constant and corresponds approximately to the intestinal loss protein . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
75,
90
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
172,
179
]
} |
suckling piglets born from them received challenge inoculation with the virulent virus at 3 days after birth , and examined for ability to prevent infection and the immunoglobulin ( ig ) classes of antibody in milk . | NA | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
165,
179
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
198,
206
]
} |
[ use of corticosteroids in pediatrics , especially in children with congenital adrenal cortex hyperplasia ( adrenogenital syndrome ) ] . | NA | {
"id": "C0302280",
"name": "congenital",
"pos": [
69,
79
]
} | {
"id": "C0001627",
"name": "adrenogenital syndrome",
"pos": [
109,
131
]
} |
this phenomenon would appear to be explained by a possible cross reaction of antibodies present in the immune sera with the normal histocompatibility antigens expressed on mast cell membranes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
77,
87
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
103,
109
]
} |
[ effect of mouse age on the ability of hematopoietic stem cells to interact with thymus cells ] . | NA | {
"id": "C0018956",
"name": "hematopoietic stem cells",
"pos": [
40,
64
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
89,
94
]
} |
the effect of the thymus cells of the c57bl/6 mice on the colony forming ability of the stem hemopoietic cells of the embryonic liver and bone marrow of young ( 3 months ) and old ( 2 years ) mice was studied their joint transplantation into the mice ( cbaxxc57bl/6 ) f1 . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "stem hemopoietic cells",
"pos": [
88,
110
]
} |
the stimulating effect of the thymus cells on the colony forming ability of the stem hemopoietic cells of different age depends both on the dose of the stem hemopoietic cells of embryonic liver and the dose of t-lymphocytes . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "stem hemopoietic cells",
"pos": [
152,
174
]
} |
this team of biophysicists studies the composition in cholesterol , cholesterol esters and phospholipids , of each type of lesion and reports it on a phase diagram , while identifying the physical state of these lipids by polarizing microscope and by x-ray diffraction . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
54,
65
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
68,
86
]
} |
a case of pregnancy in a patient with trisomy 21 with birth of a hypotrophic infant , with a normal caryotype but multiple malformations . | NA | {
"id": "C0013080",
"name": "trisomy 21",
"pos": [
38,
48
]
} | {
"id": "C0000772",
"name": "multiple malformations",
"pos": [
114,
136
]
} |
inhibition of trna methylation in vitro and in whole cells by an oncostatic s-adenosyl-homocysteine ( sah ) analogue : 5'-deoxy 5'-s-isobutyl adenosine ( siba ) . | NA | {
"id": "C0036001",
"name": "s-adenosyl-homocysteine",
"pos": [
76,
99
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
142,
151
]
} |
a high increase in the amount of methylated trna bases was found in vivo in rous sarcoma virus infected and transformed chick embryo fibroblasts in comparison with normal cells , trna methylases extracted from transformed cells showed also higher activity in vitro with a heterologous substrate . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
133,
144
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
222,
227
]
} |
[ prostaglandins and lung function . iii . effect of prostaglandin e-2 on the bronchial tree in asthma ] . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
2,
16
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
53,
68
]
} |
in vitro , the enzyme preparation cleaves an rna fragment of about 60 nucleotides from the 5 ' end of 16.3s rrna in 30s ribosomal subunits , yielding the mature 5 ' end of 16s rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
45,
48
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
176,
180
]
} |
with one single-stranded dna fragment , cleavage occurs at a position that is not attacked in double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
9,
28
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
94,
113
]
} |
viral protein spots corresponding to the hemagglutinin proteins , neuraminidase , nucleocapsid protein , and nonstructural protein , were identified on the two-dimensional electrophoretogram . | NA | {
"id": "C0042736",
"name": "viral protein",
"pos": [
0,
13
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
123,
130
]
} |
use of the two-dimensional separation has allowed us to identify glycoprotein heterogeneity , to demonstrate directly the synthesis of neuraminidase , to analyze some viral proteins early after infection , and to demonstrate that the influenza virus np and ns proteins are phosphorylated in infected mdck cells . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
167,
181
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
260,
268
]
} |
the half-life of air inactivation of the o2-labile hydrogenase ( ec 1.12.7.1 ) from clostridium pasteurianum is increased 20- to 25-fold simply by adsorption ( noncovalent binding ) in dilute tris.hcl buffer on common anion exchange supports such as deae-cellulose or dowex 1-x2 . | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
51,
62
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
65,
69
]
} |
in contrast to the heme-irreversible inhibitor , this heme-reversible inhibitor is no longer inhibitory after incubation with 20 micron hemin . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
19,
23
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
136,
141
]
} |
a stretch of six glycine residues connects the alanine at position 182 of penicillinase to the fourth amino acid , glutamine , of rat proinsulin . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
17,
24
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
102,
112
]
} |
a stretch of six glycine residues connects the alanine at position 182 of penicillinase to the fourth amino acid , glutamine , of rat proinsulin . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
47,
54
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
102,
112
]
} |
direct studies of the amino acid sequence of an escherichia coli plasmid-coded penicillinase ( penicillin amido-beta-lactamhydrolase , ec 3.5.2.6 ) are in complete agreement with results derived from the translation of the dna sequence of a related plasmid , apart from a single amino acid substitution . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
79,
92
]
} | {
"id": "C0597979",
"name": "beta-lactamhydrolase",
"pos": [
112,
132
]
} |
furthermore , differential response of dansylated lymphocytes in culture to three plant lectin mitogens provides a clue to the binding loci of concanavalin a with respect to phytohemagglutinin and pokeweed mitogen on the lymphocyte surface receptors for these lectins . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
82,
94
]
} | {
"id": "C0009630",
"name": "a",
"pos": [
236,
237
]
} |
furthermore , differential response of dansylated lymphocytes in culture to three plant lectin mitogens provides a clue to the binding loci of concanavalin a with respect to phytohemagglutinin and pokeweed mitogen on the lymphocyte surface receptors for these lectins . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
82,
94
]
} | {
"id": "C0032350",
"name": "pokeweed mitogen",
"pos": [
197,
213
]
} |
furthermore , differential response of dansylated lymphocytes in culture to three plant lectin mitogens provides a clue to the binding loci of concanavalin a with respect to phytohemagglutinin and pokeweed mitogen on the lymphocyte surface receptors for these lectins . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
82,
94
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
260,
267
]
} |
the membrane potential ( deltapsi ) was measured by distribution of the lipophilic cation [ ( 3 ) h ] triphenylmethyl phosphonium ion . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
83,
89
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
130,
133
]
} |
by indirect immunofluorescence techniques , microtubules and mitochondria were localized in normal rat kidney cells , human wi38 fibroblasts , mouse peritoneal macrophages , and a putative smooth muscle rat cell line , in monolayer culture . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
92,
98
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
129,
140
]
} |
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