text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
abelson antigen : a viral tumor antigen that is also a differentiation antigen of balb/c mice . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
8,
15
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
20,
25
]
} |
striatal extracts of guinea pigs , rats , and cattle were found to contain two large proteins ( greater than 40,000 and greater than 100,000 daltons ) that on treatment with trypsin yield opioid peptides differing chromatographically from the opioid nonapeptide generated by trypsin digestion of endorphins , beta-lipotropin , or pro-opiocortin . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
188,
203
]
} | {
"id": "C0014242",
"name": "endorphins",
"pos": [
296,
306
]
} |
striatal extracts of guinea pigs , rats , and cattle were found to contain two large proteins ( greater than 40,000 and greater than 100,000 daltons ) that on treatment with trypsin yield opioid peptides differing chromatographically from the opioid nonapeptide generated by trypsin digestion of endorphins , beta-lipotropin , or pro-opiocortin . | NA | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
309,
324
]
} | {
"id": "C0033195",
"name": "pro-opiocortin",
"pos": [
330,
344
]
} |
prostaglandin f2alpha prostaglandin e2 , progesterone , 20alpha-dihydroprogesterone and ovarian 20alpha hydroxysteroid dehydrogenase activity in preparturient pelvic neurectomized rats . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
41,
53
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
64,
83
]
} |
the results strengthen the hypothesis on the participation of gp in the regulation of neostriatal content of da and shows the interaction of the hypothetical dopaminergic pallido-striatal pathway with nigro-neostriatal pathways . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
109,
111
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
158,
170
]
} |
from literature and our experience we concluded that this syndrome is not a disease of itself but an early symptom of an intoxication or auto-intoxication process . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
58,
66
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
76,
83
]
} |
l-dopa ( 10 mg/rat/day ) did not modify the adenohypophyseal reaction , either alone or combined with the dopa-decarboxylate inhibitor ro-4-4602 ( 1 mg/rat/day ) . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
0,
6
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
106,
110
]
} |
fatty tissues and tumors have been described as characteristically cyst-like on ultrasound examination , with relatively few internal echoes . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
18,
24
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
67,
71
]
} |
there were three solitary angiomyolipomata ( renal hamartoma ) , a presumed diffuse hamartomatous involvement of the kidney in a patient with tuberous sclerosis , and one myelolipoma of the adrenal gland . | NA | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
84,
97
]
} | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
142,
160
]
} |
functional aspects of odontocete head oil lipids with special reference to pilot whale head oil . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
42,
48
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
92,
95
]
} |
with respect to the microvillous hydrolases ( lactase , alpha-d-glucosidases , peptidases , alkaline phosphatase ) histochemical and biochemical assays were carried out with the same artificial substrate . | NA | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
33,
43
]
} | {
"id": "C0030940",
"name": "peptidases",
"pos": [
79,
89
]
} |
alpha-d-glucosidases ( glucoamylase , saccharaseisomaltase ) become mature at the end of the first , and the development of lactase is finished after the second week of life . | NA | {
"id": "C0017764",
"name": "glucosidases",
"pos": [
8,
20
]
} | {
"id": "C0015278",
"name": "glucoamylase",
"pos": [
23,
35
]
} |
ovarian and uterine tissue concentrations of progesterone , 20alpha-dihydroprogesterone ( 20alphaohp ) and prostaglandin f ( pgf ) were measured during hormonally-induced pseudopregnancy , as were plasma levels of progesterone and 20alphaohp , in hysterectomised and sham-operated rats . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
45,
57
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
68,
87
]
} |
the efficiency of the method was checked in several cases of radionecrosis of the hand , deep burns with complete destruction of the tissues on the back of the hand , severe trauma with tearing of the teguments and uncovering of the bones . | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
94,
99
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
174,
180
]
} |
these results support the idea that the brain levels of corticosteroid are determined by the existing plasma levels and by the duration of the hormone elevation . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
56,
70
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
143,
150
]
} |
flurazepam , temazepam , lorazepam , flunitrazepam and diazepam had an inhibitory effect on plasma cholinesterase of 60 -- 90 per cent and , with the exception of lorazepam , an inhibitory effect of 40 -- 50 per cent on red cell cholinesterase . | NA | {
"id": "C0008429",
"name": "plasma cholinesterase",
"pos": [
92,
113
]
} | {
"id": "C0001044",
"name": "red cell cholinesterase",
"pos": [
220,
243
]
} |
in the present study so2 ( 0.08 -- 0.32 vol % ) added to the ventilating gas stream caused a loss of pacing in 11 of 12 birds . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
21,
24
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
73,
76
]
} |
pyelonephritis xanthogranulomatosa is a peculiar manifestation of destructive interstitial nephritis which can be differentiated from other types of pyonephrosis exclusively by microscopic examination . | NA | {
"id": "C0034186",
"name": "pyelonephritis",
"pos": [
0,
14
]
} | {
"id": "C0027707",
"name": "interstitial nephritis",
"pos": [
78,
100
]
} |
most cardiac abnormalities occur in conjunction with a more or less pronounced cardiomegaly , and only the tetralogy of fallot , tricuspid atresia , and total anomalous pulmonary venous drainage are associated with a heart of normal or only slightly enlarged size . | NA | {
"id": "C0018798",
"name": "cardiac abnormalities",
"pos": [
5,
26
]
} | {
"id": "C0039685",
"name": "tetralogy of fallot",
"pos": [
107,
126
]
} |
most cardiac abnormalities occur in conjunction with a more or less pronounced cardiomegaly , and only the tetralogy of fallot , tricuspid atresia , and total anomalous pulmonary venous drainage are associated with a heart of normal or only slightly enlarged size . | NA | {
"id": "C0018798",
"name": "cardiac abnormalities",
"pos": [
5,
26
]
} | {
"id": "C0243002",
"name": "tricuspid",
"pos": [
129,
138
]
} |
this indicates that the zinc from the tape is present in the body not as zinc oxide , as it is in the adhesive substance of the tape , but as zinc in those forms which are originally found in the body and that zinc oxide is ionized before absorption . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
24,
28
]
} | {
"id": "C0043491",
"name": "zinc oxide",
"pos": [
210,
220
]
} |
fibrinogen , fibrin ( ogen ) degradation products ( fdp ) and fibrinopeptide a ( fpa ) were analysed in pleural fluids from 20 consecutive patients with major effusions of various aetiology . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
0,
6
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
62,
78
]
} |
fpa is a short-lived polypeptide which is split off from fibrinogen , whereafter fibrin is formed . | NA | {
"id": "C0016022",
"name": "fpa",
"pos": [
0,
3
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
81,
87
]
} |
high fpa concentrations , interpreted as reflecting very recent fibrin formation , were found in all pleural fluids except for one case of empyema and one transudate . | NA | {
"id": "C0016022",
"name": "fpa",
"pos": [
5,
8
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
64,
70
]
} |
these results show that the so-called hypercoagulability is not accompanied by thrombin-mediated release of fibrinopeptide a , and suggest that the activation of coagulation does not involve fibrinogen to fibrin conversion . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
108,
124
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
205,
211
]
} |
a grade 3 to grade 4 astrocytoma ( resembling a human glioblastoma multiforme ) was found in the left cerebral hemisphere and brainstem of one monkey . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
21,
32
]
} | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
54,
77
]
} |
dna associated with this protein is more stable than free dna against thermal denaturation by about 40 degrees c , as shown in both native nucleoprotein and in hybrid nucleoprotein reconstituted in vitro with calf dna . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
25,
32
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
167,
180
]
} |
a role for adenosine 3',5'-monophosphate ( cyclic amp ) in modulating macrophage functional activity was suggested because prostaglandins of the e series increase intracellular concentrations of cyclic amp in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic amp consistently inhibits expression of cytotoxicity . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
43,
53
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
284,
304
]
} |
the author discusses the physiopathology of neuromotor disorders wuch as parkinson 's disease , chorea , and various types of dyskinesias , in relation to this dual mediation . | NA | {
"id": "C0008489",
"name": "chorea",
"pos": [
96,
102
]
} | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
126,
137
]
} |
it has been shown to be effective in 66 % of cases of headaches and pain resistant to therapy , and 75 % of patients with nausea and vomiting associated with headaches . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
68,
72
]
} | {
"id": "C0018681",
"name": "headaches",
"pos": [
158,
167
]
} |
it is therefore postulated that the abnormal lymphoid cell involved in b-cell disorders is an end-stage cell and not the haemopoietic stem cell . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
54,
58
]
} | {
"id": "C0018956",
"name": "haemopoietic stem",
"pos": [
121,
138
]
} |
the lesion occurs on the extremities , particularly the soles of the feet , the palms of the hands and the digits , but otherwise has the clinical , histological and prognostic features of hutchinson 's melanotic freckle with melanoma . | NA | {
"id": "C0149722",
"name": "hutchinson 's melanotic freckle",
"pos": [
189,
220
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
226,
234
]
} |
despite the striking elevation of ache activity in fibroblasts trisomic for chromosome 2 , extracts of these cells had only about 1.5 % of the specific ache activity ( per microgram dna ) present in extracts of human cerebral cortex . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
109,
114
]
} |
the isolation of the valyl-trna synthetase mutant reported here brings to eight the number of different aminoacyl-trna synthetase mutants isolated in the cho cell line . | NA | {
"id": "C0042301",
"name": "valyl-trna synthetase",
"pos": [
21,
42
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetase",
"pos": [
104,
129
]
} |
haemothorax , haemopneumothorax , and pneumothorax were the most common complications in 85 patients with penetrating stab injuries of the chest . | NA | {
"id": "C0019123",
"name": "haemothorax",
"pos": [
0,
11
]
} | {
"id": "C0019077",
"name": "haemopneumothorax",
"pos": [
14,
31
]
} |
isolated coarctation was present in 6 infants , 17 also had patent ductus arteriosus , 39 patients had additional associated cardiac anomalies , part of which were combined with pda . | NA | {
"id": "C0003492",
"name": "coarctation",
"pos": [
9,
20
]
} | {
"id": "C0018798",
"name": "cardiac anomalies",
"pos": [
125,
142
]
} |
isolated coarctation was present in 6 infants , 17 also had patent ductus arteriosus , 39 patients had additional associated cardiac anomalies , part of which were combined with pda . | NA | {
"id": "C0018798",
"name": "cardiac anomalies",
"pos": [
125,
142
]
} | {
"id": "C0013274",
"name": "pda",
"pos": [
178,
181
]
} |
simultaneous application of bile salt enhanced the activity of edta.4na , hydrophilizing the gallstone surface to facilitate chelating reaction and also dissolving minor fatty components of the stone . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
93,
102
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
194,
199
]
} |
the effects of a number of steroids on the conversion of progesterone to 5alpha-dihydroprogesterone by hypothalamic and pituitary progesterone 5alpha-reductase have been investigated . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
57,
69
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
80,
99
]
} |
using enzyme preparations from female rats and 3h-progesterone as substrate , 5alpha-reduced products ( 5alpha-dihydroprogesterone and 3alpha-hydroxy-5alpha-pregnan-20-one ) were analyzed by reverse isotopic dilution analysis . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
50,
62
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
111,
130
]
} |
cultured rabbit fibroblasts of bone marrow , thymus and spleen origin were added in spleen cell cultures in which the primary antibody response to srbc was induced . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
91,
95
]
} |
the stimulation of antibody forming cell response by thymus fibroblasts proved independent of whether fibroblasts were irradiated or not . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} |
all the 3 types of fibroblasts did not influence cell viability in spleen cells cultures , and were much more effective on addition to cultures of a-deficient spleen cells as compared to full spleen cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} |
the obtained data suggest the possibility of a secondary inflammatory origin of pain in deforming arthrosis and witness an important role played by the surgical prevention and correction of the joint instability in clinical remission of th disease . | NA | {
"id": "C0022408",
"name": "arthrosis",
"pos": [
98,
107
]
} | {
"id": "C0022410",
"name": "of",
"pos": [
234,
236
]
} |
better anatomical and functional results in the treatment of malunion , ununited fractures and pseudoarthrosis are gained through the combination of compression osteosynthesis with bone plasty and open reduction of the dislocated capitellum with the formation of the ligamental system . | NA | {
"id": "C0016665",
"name": "ununited",
"pos": [
72,
80
]
} | {
"id": "C0033785",
"name": "pseudoarthrosis",
"pos": [
95,
110
]
} |
it was found that in hyperbaric oxygenation the normalization of metabolic processes in an ischemic tissue takes place together with the elimination of oxygen deficit and deviations in acid-base status . | NA | {
"id": "C0025519",
"name": "metabolic processes",
"pos": [
65,
84
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
137,
148
]
} |
the tumor consisted of neural cells , cysts lined by various types of epithelium , respiratory mucosa , gastric mucosa , mucous and mucoserous glands , collagenous connective tissue , cartilage and fat . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
4,
9
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
38,
43
]
} |
intramuscular injections of 4 or 8 mg 25-hydroxycholecalciferol ( 25-oh d3 ) in 5 ml corn oil given three days before the predicted calving date and repeated at weekly intervals until calving effectively reduced the incidence of parturient paresis . | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
38,
63
]
} | {
"id": "C2713074",
"name": "25-oh d3",
"pos": [
66,
74
]
} |
with this immunization schedule it was possible to obtain smallpox antisera containing precipitins ( in a titer of 1:32 ) , hemagglutinins ( 1:1280 ) , and antibody detectable by the indirect immunofluorescence technique ( 1:2560 ) . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
67,
75
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
156,
164
]
} |
with this immunization schedule it was possible to obtain smallpox antisera containing precipitins ( in a titer of 1:32 ) , hemagglutinins ( 1:1280 ) , and antibody detectable by the indirect immunofluorescence technique ( 1:2560 ) . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
87,
98
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
156,
164
]
} |
the changes in hemodynamics in conditions of dosed loading prior to and post cardioversion were followed up in 21 patients with valvular defects or atherosclerotic myocardiosclerosis and absolute arrhythmia with auricular fibrillation . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
196,
206
]
} | {
"id": "C0004238",
"name": "auricular",
"pos": [
212,
221
]
} |
the metabolic functions of rbc were investigated by assaying hmps activity , gsh/gssg and lactate/pyruvate ratios , relevant glycolytic intermediates , 2,3-dpg , atp , and key enzymes . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
77,
80
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
81,
85
]
} |
the fate of saccharin impurities : the excretion and metabolism of [ 3-14c ] benz [ d ] -isothiazoline-1,1-dioxide ( bit ) in man and rat . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
39,
48
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
53,
63
]
} |
the fate of saccharin impurities : the metabolism and excretion of 3-amino [ 3-14c ] benz [ d ] -isothiazole-1,1-dioxide and 5-chlorosaccharin in the rat . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
39,
49
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
54,
63
]
} |
the metabolic fate of a new antitumour agent , 1-hexylcarbamoyl-5-fluoro [ 6-14c ] uracil ( 14c-hcfu ) in rats after oral administration was compared with that of 5-fluoro [ 6-14c ] uracil ( 14c-fu ) . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
83,
89
]
} | {
"id": "C0016360",
"name": "fu",
"pos": [
195,
197
]
} |
in all cases , the levels of d-fenfluramine were higher than those of the l-enantiomer , while levels of the metabolite norfenfluramine were lower for the d- than the l-form . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
31,
43
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
120,
135
]
} |
the existence of the linear phase is discussed in connection with a constant activity of one of the two 2-ketoacid dehydrogenases as a bottle neck enzyme which needs thiamine pyrophosphate as coenzyme . | NA | {
"id": "C0039848",
"name": "thiamine",
"pos": [
166,
174
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
192,
200
]
} |
[ the behavior of albumin in acute and chronic liver damage . iii . intrahepatic and serum albumin concentrations in human liver diseases ] . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
18,
25
]
} | {
"id": "C0304925",
"name": "serum albumin",
"pos": [
85,
98
]
} |
in 305 patients examined by liver biopsy albumin and the entire soluble protein in the liver puncture as well as albumin in the serum were estimated quantitatively . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
41,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
72,
79
]
} |
in 305 patients examined by liver biopsy albumin and the entire soluble protein in the liver puncture as well as albumin in the serum were estimated quantitatively . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
41,
48
]
} | {
"id": "C0036773",
"name": "albumin",
"pos": [
113,
120
]
} |
myocardial adenine nucleotides ( nicotinamide adenine nucleotides included ) , glutathione , catecholamines ( dopa , dopamine , noradrenaline , adrenaline ) and some enzymes in correlation were investigated in dogs with cardiac failure induced by bilateral iliac arteriovenous fistulas , and unilateral ( left ) heart vagotomy was also studied for its influence on the changes in the myocardial amounts of these compounds occuring in this pathological circumstance . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
93,
107
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
117,
121
]
} |
myocardial adenine nucleotides ( nicotinamide adenine nucleotides included ) , glutathione , catecholamines ( dopa , dopamine , noradrenaline , adrenaline ) and some enzymes in correlation were investigated in dogs with cardiac failure induced by bilateral iliac arteriovenous fistulas , and unilateral ( left ) heart vagotomy was also studied for its influence on the changes in the myocardial amounts of these compounds occuring in this pathological circumstance . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
128,
141
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
144,
154
]
} |
the essential oil obtained from oranges of different origin leaves a dark red oil after purification . | NA | {
"id": "C0028910",
"name": "essential oil",
"pos": [
4,
17
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
78,
81
]
} |
electronmicroscopic finding of surface structure and capsular swelling reaction of a strain of klebsiella pneumoniae . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
20,
27
]
} | {
"id": "C0013604",
"name": "swelling",
"pos": [
62,
70
]
} |
the changes and accumulation of antibodies of various classes in children and adults during the enteral immunization with live dysentery vaccine differed significantly : in children the vaccine stimulated the iga- and the igm-antibody synthesis , whereas adults responded to the immunization by increased production of all the 3 antibody classes . | NA | {
"id": "C0021017",
"name": "antibodies",
"pos": [
32,
42
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
329,
337
]
} |
an increased dose of the antigen suppressed the ingestive and the digestive functions of macrophages , this apparently being caused by the manifestation of the immunodepressive activity of the residual amount of lipopolysaccharide ( endotoxin ) in the protective antigen . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
212,
230
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
233,
242
]
} |
results of determination of the influence of the circulating antibodies on the intensity of tissue respiration and the processes of dehydration in the hepatic tissue showed antihepatic autoantibodies to produce a cytotoxic ( aggressive ) action . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
61,
71
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
185,
199
]
} |
the influence of duration of the lipopolysaccharide hydrolysis on the fatty acid content in lipid a , and of heptose in the specific polysaccharide was demonstrated . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
33,
51
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
92,
99
]
} |
stability of the lipopolysaccharide complex bond depended on heptose and lipid a content and on the composition and the amount of fatty acids in the lipid a preparations . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
17,
35
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
149,
156
]
} |
biosynthesis of both homologous and heterologous antibodies had its specific features for each serological group of the disease , and was characterized by the quadripol dynamics of 19s-macro and 7s-microglobulin antibodies production in leptospiroses of serological groups pomona and gryppotyphosa , whereas in leptospiroses of serological groups icterohaemorrhagiae and hebdomadis a graphically dipolic synthesis dynamics of 19s-macroglobulin antibodies alone was noted . | NA | {
"id": "C0023364",
"name": "leptospiroses",
"pos": [
237,
250
]
} | {
"id": "C0043102",
"name": "leptospiroses",
"pos": [
311,
324
]
} |
group antibodies of plaque antiserum and serum procured from the pseudoteburculosis convalescent produced a cross antitoxic action . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
27,
36
]
} |
a study of the catecholamine excretion , their precursor dopa and final metabolites -- homovaniline and vanilylphenylglycolic acid in torsion dystonia , detected certain changes which were different in patients with various clinical forms of the disease . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
15,
28
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
57,
61
]
} |
the detected characters of a primary speech defect in senile atrophy permitted to allocate speech disorders in such cases to genuine aphatical ( focal ) -- the syndrome of superior-temporal area of the left hemisphere of the temporal-acoustical aphasia according to a.r . | NA | {
"id": "C0037822",
"name": "speech disorders",
"pos": [
91,
107
]
} | {
"id": "C0003537",
"name": "syndrome",
"pos": [
160,
168
]
} |
examination of 15 patients with tumors of the brain in whom the presence of subdural hematomas could not be excluded and of 27 patients with chronic subdural hematomas revealed that displacement of the m-echo was 8 +/- 0.43 mm on the average in chronic subdural hematomas and 5.6 +/- 0.43 mm in tumors . | NA | {
"id": "C0018946",
"name": "subdural hematomas",
"pos": [
76,
94
]
} | {
"id": "C0749095",
"name": "chronic subdural hematomas",
"pos": [
245,
271
]
} |
the treatment should be aimed at partial removal of the tumor or evacuation of the cyst , decompression of the stem , and restoration of c.s.f . drainage by applying bilateral ventriculo-cisternal drainage . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
56,
61
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
83,
87
]
} |
after in vitro incubation with a nadph generating system , which under the conditions used was a much stronger stimulus for steroid biosynthesis than hcg or dibutyryl camp , the tissue of young rats produced about twice the amount of testosterone precursors ( pregnenolone , progesterone , 17alpha-hydroxyprogesterone and androstenedione ) than old tissue . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
275,
287
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
290,
317
]
} |
the right lobar flow was 86.20 +/- 12.83 ml/100 gm/min in 3 patients without liver disease , 75.12 +/- 14.54 ml/100 gm/min in 12 with chronic hepatitis and 51.24 +/- 17.13 ml/100 gm/min in 11 with liver cirrhosis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
77,
90
]
} | {
"id": "C0023890",
"name": "liver",
"pos": [
197,
202
]
} |
serum concentrations of paracetamol were followed after oral administration of the drug to 21 patients with liver cirrhosis , 4 patients with secondary liver cancer , and 15 hospitalized patients without clinical evidence of liver disease . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
108,
123
]
} | {
"id": "C0023895",
"name": "of liver disease",
"pos": [
222,
238
]
} |
these pure catalases induced , after injecting into guinea-pigs , anti-serums that react specifically with catalase and does not give any cross reaction with peroxidases and haemic iron containing compounds . | NA | {
"id": "C0007367",
"name": "catalase",
"pos": [
11,
19
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
158,
169
]
} |
factor 1 showed a correlation to alpha-amino-n-butyric acid , valine , methionine , isoleucine , leucine , tyrosine and phenylalanine , factor 2 to lysine , histidine , arginine and glutamine ( containing serine ) , factor 3 to taurine and proline , factor 4 to glycine and cystine , factor 5 to urea and factor 6 to glutamic acid . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
182,
191
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
317,
330
]
} |
lactoferrin is an iron-binding glycoprotein which plays a role in the defence against gastro-intestinal infections and is probably also involved in iron transport in the gut . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
0,
11
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
31,
43
]
} |
the birthweight , placental weight and number of placental cotyledons were significantly reduced in the severely anaemic mothers ( haemoglobin less than or equal to 60 g/l ) and had direct relationships with the maternal haemoglobin levels . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
4,
15
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
28,
34
]
} |
the incorporation of 3h-leucine into protein from anterior and posterior cerebellum , cerebral cortex and liver was studied in rats given 50 % of calories as ethanol , brandy , whisky , gin , red wine or isocaloric amounts of glucose together with diets with moderate or low protein-vitamin content for 8 -- 9 months . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
158,
165
]
} | {
"id": "C0475610",
"name": "whisky",
"pos": [
177,
183
]
} |
in view of the poor absorption , rapid metabolism and excretion of curcumin , it is unlikely that substantial concentrations of curcumin occur in the body after ingestion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
39,
49
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
54,
63
]
} |
in order to study effects of catecholamines on cerebral oxygen consumption ( cmro2 ) and blood flow ( cbf ) , rats maintained on 75 % n2o and 25 % o2 were infused i.v . with noradrenaline ( 2 , 5 , or 8 microgram.kg-1.min-1 ) or adrenaline ( 2 or 8 microgram.kg-1.min-1 ) for 10 min before cbf and cmro2 were measured . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
174,
187
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
229,
239
]
} |
ca uptake by microsomes isolated from non-pregnant rabbit myometrium was potentiated by both inorganic phosphate ( pi ) and oxalate anions . | NA | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
93,
112
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
132,
138
]
} |
the results suggest that ca is taken up by a different mechanism in the presence of oxalate than that in its absence or when oxalate anion is substituted with inorganic phosphate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
133,
138
]
} | {
"id": "C0031603",
"name": "inorganic",
"pos": [
159,
168
]
} |
the intestinal mucosal barrier of rabbits was damaged by carrageenan-induced ulceration of the colon , superior mesenteric artery occlusion ( smao ) and hemorrhagic shock and the values of endotoxin ( lipopolysaccharide , lps ) were determined by radioimmunoassay and the concentration of lysozyme ( lzm ) by the turbidimetric method . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
189,
198
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
222,
225
]
} |
the binding indices of platelets in experimental endotoxemia which was induced by intravenous administration of endotoxin ( lipopolysaccharide of e. coli , difco ) to rabbits were found to be 30 % of the control at 60 min after the injection . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
112,
121
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
124,
142
]
} |
one interpretation is that there is a common receptor on platelet cell membranes for lipopolysaccharide of e. coli and endotoxin . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
85,
103
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
119,
128
]
} |
in 13 iron deficient patients the absorption from 100 mg ferrous sulphate ( ferro-retard ) after 3 and 5 hours was comparable to the absorption from 176 mg ferrous gluconate in rapidly disintegrating tablets ( ferronicum ) . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
6,
10
]
} | {
"id": "C0060282",
"name": "ferrous",
"pos": [
156,
163
]
} |
in 13 iron deficient patients the absorption from 100 mg ferrous sulphate ( ferro-retard ) after 3 and 5 hours was comparable to the absorption from 176 mg ferrous gluconate in rapidly disintegrating tablets ( ferronicum ) . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
6,
10
]
} | {
"id": "C0060277",
"name": "ferrous gluconate",
"pos": [
156,
173
]
} |
dopaminergic receptor activity in substantia nigra in the mechanisms of autoregulation of striatal dopamine release . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
0,
12
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
99,
107
]
} |
other proteins were also identified on page of trypsinized pns myelin : albumin , p2 protein , and po protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
72,
79
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
102,
109
]
} |
albumin and p2 protein were identified in the acidic extract by reaction with specific antibody . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
0,
7
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
15,
22
]
} |
the finding that whole activated lymphocytes are capable of hydrolyzing basic protein suggests that these cells which are believed to be precursors of mononuclear cells migrating into the central nervous system may be active agents in the early stages of myelin dissolution in experimental allergic encephalomyelitis . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
137,
147
]
} |
the role of virus infection in progressive multifocal leukoencephalopathy , subacute sclerosing panencephalitis , visna and mouse hepatitis virus infections , is discussed in relation to the demyelinating process of these diseases . | NA | {
"id": "C0023524",
"name": "progressive",
"pos": [
31,
42
]
} | {
"id": "C0011303",
"name": "demyelinating",
"pos": [
191,
204
]
} |
retarded body and brain growth and a deficit of myelin in the cerebral hemispheres and the cerebellum were observed in an animal model of phenylketonuria , the p-chlorophenylalanine and l-phenylalanine treated preweanling rat . | NA | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
160,
181
]
} | {
"id": "C0031453",
"name": "l-phenylalanine",
"pos": [
186,
201
]
} |
the interaction of chloride with the enzyme is dependent on the ca complex with the membrane in that solubilization and partial ( 60-fold ) purification results in a preparation which is refractory to anions . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
19,
27
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
201,
207
]
} |
the naphthol -- asbi phosphoric acid -- pararosaniline method is highly specific and is best for histochemical demonstration of acid phosphatase and tartrate-resistant acid phosphatase in tissue sections . | NA | {
"id": "C0001109",
"name": "acid phosphatase",
"pos": [
128,
144
]
} | {
"id": "C0297331",
"name": "tartrate-resistant acid phosphatase",
"pos": [
149,
184
]
} |
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