text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
they included 21 cases of focal nodular hyperplasia , 11 cases of hepatic cell adenoma , 12 cases of bile-duct adenoma and a single case of mesenchymal hamartoma . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
79,
86
]
} | {
"id": "C0008309",
"name": "of bile-duct adenoma",
"pos": [
98,
118
]
} |
the tumor was composed of malignant stroma containing undifferentiated mesenchymal cells admixed with mature fibroblasts and other cell that contained crystalloids . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
131,
135
]
} |
a case of gold-induced aplastic anemia occurring in a 58-year-old male with rheumatoid arthritis who received a total dose of 635 mg of gold sodium thiomalate over a 16-week period is reported . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
10,
14
]
} | {
"id": "C0018034",
"name": "gold sodium",
"pos": [
136,
147
]
} |
effect of the specific angiotensin antagonist ( sar1 ) ( ala8 ) angiotensin ii on blood pressure and the renin-angiotensin system in the conscious pregnant ewe and fetus . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
23,
34
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
64,
78
]
} |
when this simple atomic model for ionic screening is employed in conjunction with equilibrium ion-selectivity theory , it is possible to predict quantitatively , from coulombic energy calculations , the secondary stereospecific actions of certain alkaline-earth cations as well as the predominant screening effect of these divalent cations at the surfaces of different types of membranes . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
34,
39
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
332,
339
]
} |
when this simple atomic model for ionic screening is employed in conjunction with equilibrium ion-selectivity theory , it is possible to predict quantitatively , from coulombic energy calculations , the secondary stereospecific actions of certain alkaline-earth cations as well as the predominant screening effect of these divalent cations at the surfaces of different types of membranes . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
262,
269
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
323,
339
]
} |
it is concluded that during postexercise recovery , a greater proportion of an oral glucose load escapes hepatic retention , allowing repletion of muscle glycogen to take precedence over hepatic glycogen repletion . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
154,
162
]
} | {
"id": "C0023902",
"name": "hepatic glycogen",
"pos": [
187,
203
]
} |
electrophysiological techniques were used in isolated perfused superficial ( s ) and juxtamedullary ( jm ) rabbit proximal convoluted tubules ( pct ) to examine the relative sodium-to-chloride ( pna/pcl ) and bicarbonate-to-chloride ( phco3/pcl ) permeability ratios . | NA | {
"id": "C0037494",
"name": "sodium",
"pos": [
174,
180
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
224,
232
]
} |
the specific activity of glycogen was much higher than that of blood glucose after the glucose load , indicating that glycogen originated from gluconeogenesis rather than blood glucose . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
69,
76
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
171,
184
]
} |
it is concluded that a glucose load diverts the final product of hepatic gluconeogenesis from blood glucose to liver glycogen ; | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
23,
30
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
94,
107
]
} |
the effects of three tetracyclines , demethylchlortetracycline ( dmc ) , minocycline ( mnc ) , and oxytetracycline ( otc ) , on na+ transport ( measured as short-circuit current ) were examined in toad urinary bladders mounted in modified ussing chambers . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
21,
34
]
} | {
"id": "C0011276",
"name": "demethylchlortetracycline",
"pos": [
37,
62
]
} |
the effects of three tetracyclines , demethylchlortetracycline ( dmc ) , minocycline ( mnc ) , and oxytetracycline ( otc ) , on na+ transport ( measured as short-circuit current ) were examined in toad urinary bladders mounted in modified ussing chambers . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
21,
34
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
73,
84
]
} |
the effects of three tetracyclines , demethylchlortetracycline ( dmc ) , minocycline ( mnc ) , and oxytetracycline ( otc ) , on na+ transport ( measured as short-circuit current ) were examined in toad urinary bladders mounted in modified ussing chambers . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
21,
34
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
99,
114
]
} |
this effect does not correlate with the known effects of the tetracyclines on adh-stimulated water flow or with drug-protein binding , and may be related to the greater lipid solubility of mnc . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
61,
74
]
} | {
"id": "C0026187",
"name": "mnc",
"pos": [
189,
192
]
} |
massive muscle destruction ( rhabdomyolysis ) with myoglobinuria and acute renal failure make this case of particular interest . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
29,
43
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
51,
64
]
} |
synthesis rates of glycosaminoglycans by wi-38 cultures ( diploid , human fibroblasts exhibiting a limited number of population doublings in vitro ) were determined by incorporation of 35s-sulfate of 14c-glucosamine into cellular and extracellular glycosaminoglycans at different passage levels before phase out . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
74,
85
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
239,
247
]
} |
analysis of the distribution pattern of incorporated label into various glycosaminoglycan types ( hyaluronic acid , chondroitin sulfate , dermatan sulfate and possibly heparan sulfate ) revealed an age-related relatively stonger decline of 14c-glucosamine incorporation into cellular and extracellular hyaluronic acid and of 35s-sulfate into extracellular chondroitin sulfate in comparison with the other glycosaminoglycan types . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
168,
183
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
405,
422
]
} |
addition of exogenous glycosaminoglycans ( chondroitin-4-sulfate , chondroitin-6-sulfate , dermatan sulfate , hyaluronic acid , heparan sulfate , heparin ) at 100 microgram/ml to the culture media during the last 7 to 10 population doublings before phase out did not increase the total number of population-doublings . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
22,
40
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
128,
143
]
} |
addition of exogenous glycosaminoglycans ( chondroitin-4-sulfate , chondroitin-6-sulfate , dermatan sulfate , hyaluronic acid , heparan sulfate , heparin ) at 100 microgram/ml to the culture media during the last 7 to 10 population doublings before phase out did not increase the total number of population-doublings . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
22,
40
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
146,
153
]
} |
morphine antagonists such as methadone , nalophine , naloxone and naltrexone possess specific problems in terms of their utilization . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
53,
61
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
66,
76
]
} |
results indicated that both ozone and o2 initiated a proliferative response of terminal bronchiolar epithelium , but that the response to o2 insult was delayed in onset and of lesser magnitude . | NA | {
"id": "C0030106",
"name": "ozone",
"pos": [
28,
33
]
} | {
"id": "C0030054",
"name": "o2",
"pos": [
138,
140
]
} |
four children who at ages from five months to three years developed an acute ( one case ) , subacute ( two cases ) and chronic form ( one case ) clinical picture of ataxia , myoclonus , ocular dyskinesia and behaviour disorder are reported . | NA | {
"id": "C0004134",
"name": "ataxia",
"pos": [
165,
171
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
193,
203
]
} |
four children who at ages from five months to three years developed an acute ( one case ) , subacute ( two cases ) and chronic form ( one case ) clinical picture of ataxia , myoclonus , ocular dyskinesia and behaviour disorder are reported . | NA | {
"id": "C0027066",
"name": "myoclonus",
"pos": [
174,
183
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
193,
203
]
} |
cellular and immunoglobulin components of bronchoalveolar fluid recovered by bronchoscopic lavage were evaluated in 32 control patients , 10 normal volunteers , and 60 patients with the following interstitial lung diseases : idiopathic pulmonary fibrosis , pulmonary fibrosis associated with collagen-vascular disease , eosinophilic granuloma , sarcoidosis , and hypersensitivity pneumonitis . | NA | {
"id": "C0206062",
"name": "interstitial lung diseases",
"pos": [
196,
222
]
} | {
"id": "C0002390",
"name": "hypersensitivity pneumonitis",
"pos": [
363,
391
]
} |
although it is generally admitted that gram-positive bacteria can not induce interferon , we were able to show that organisms and cell walls of bacillis subtilis as well as components obtained through the extraction of endotoxins from gram-negative bacteria can induce type ii interferon . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
77,
87
]
} | {
"id": "C0021745",
"name": "type ii interferon",
"pos": [
269,
287
]
} |
however , it has appeared that chemically they are quite different from the lipopolysaccharide of the gram-negative bacteria : no lipid a could be detected . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
76,
94
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
130,
137
]
} |
ocular hypertension induced by an intragastric water load in rabbits is significantly inhibited by continuous delivery of epinephrine at the rates of 3 or 6 microgram/hr , or by 2 % epinephrine bitartrate ( 1 % free base ) eyedrops . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} | {
"id": "C0700536",
"name": "epinephrine bitartrate",
"pos": [
182,
204
]
} |
unlike those mucopolysaccharidoses , however , no abnormalities were found in the gangliosides in the brain of the patient with morquio syndrome . | NA | {
"id": "C0026703",
"name": "mucopolysaccharidoses",
"pos": [
13,
34
]
} | {
"id": "C0026707",
"name": "morquio syndrome",
"pos": [
128,
144
]
} |
sensitivity of 4 clinical strains of staph . aureus and e. coli to 13 hydroacridine derivatives and their combinations with antibiotics , such as benzylpenicillin , ampicillin , semi-synthetic penicillins , streptomycin , chloramphenicol , tetracycline , chlortetracycline , monomycin , oleandomycin and erythromycin was studied . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
146,
162
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
165,
175
]
} |
the highest bacteriostatic effect was observed on the use of perhydroactidine derivatives with benzylpenicillin or ampicillin with respect to polyresistant penicillinase-producing strains of staph . aureus , resistance of which to these antibiotics was decreased 250 -- 1000 times . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
95,
111
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
115,
125
]
} |
[ effect of microbial and tumor cell adaptation to rubomycin on their uptake of rubomycin and carminomycin ] . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
51,
60
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
94,
106
]
} |
anthracycline antibiotics rubomycin ( daunomycin ) and carminomycin rapidly accumulated in the bacterial and ascitic tumor cells and their intracellular concentrations significantly exceeded the concentrations in the medium . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
38,
48
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
55,
67
]
} |
the strains of staph . aureus and fisher mouse ascitic lymphadenosis l-5178/p resistant to rubomycin preserved sensitivity to carminomycin . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
91,
100
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
126,
138
]
} |
at the same time carminomycin also effectively accumulated in the cells of staph . aureus and fisher ascitic lymphadenosis adapted to rubomycin , the same as in the cells of the parent strains . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
17,
29
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
134,
143
]
} |
the pharmacokinetics of cefaclor and cephalexin were characterized in patients with creatinine clearances ranging from 0 to 147 ml/min . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
24,
32
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
37,
47
]
} |
the serum half-lives were highly correlated with corrected creatinine clearance ( cefaclor r = 0.92 , cephalexin r = 0.94 ) . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
82,
90
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
102,
112
]
} |
the activity of sch 21420 was comparable to gentamicin , sisomicin , netilmicin , and tobramycin but greater than amikacin or kanamycin against s. aureus and most genera of enterobacteriaceae . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
44,
54
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
57,
66
]
} |
the activity of sch 21420 was comparable to gentamicin , sisomicin , netilmicin , and tobramycin but greater than amikacin or kanamycin against s. aureus and most genera of enterobacteriaceae . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
57,
66
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
69,
79
]
} |
the activity of sch 21420 was comparable to gentamicin , sisomicin , netilmicin , and tobramycin but greater than amikacin or kanamycin against s. aureus and most genera of enterobacteriaceae . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
114,
122
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
126,
135
]
} |
sch 21420 , amikacin , and kanamycin were ( i ) more active than the other five aminoglycosides against proteus rettgeri and providencia stuartii , but ( ii ) less active than the other five aminoglycosides against neisseria gonorrhoeae , enterococci , most nonfermenting gram-negative bacilli , proteus mirabilis , and proteus morganii . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
12,
20
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
27,
36
]
} |
uk-18892 is a new aminoglycoside antibiotic , a derivative of kanamycin a structurally related to amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
62,
71
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
98,
106
]
} |
binding of the cephalosporins to dog serum ranged from 31 % for cephaloridine to 46 % for cephalothin , considerably lower than human serum binding for cefazolin , cephalothin , and cefamandole . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
15,
29
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
64,
77
]
} |
a carbenicillin-resistant mutant of pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin , ampicillin , carbenicillin , and cephaloridine than that of the parent strain . | NA | {
"id": "C0030827",
"name": "benzyl penicillin",
"pos": [
168,
185
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
188,
198
]
} |
a carbenicillin-resistant mutant of pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin , ampicillin , carbenicillin , and cephaloridine than that of the parent strain . | NA | {
"id": "C0030827",
"name": "benzyl penicillin",
"pos": [
168,
185
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
201,
214
]
} |
forty-nine powdered herbal drugs were analyzed for their mold profile and for the potential presence of three mycotoxins ( aflatoxin , sterigmatocystin , ochratoxin a ) . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
110,
120
]
} | {
"id": "C0038274",
"name": "sterigmatocystin",
"pos": [
135,
151
]
} |
an effort was made to relate the degree of oxygen tolerance to the activities of superoxide dismutase , catalase , and peroxidases in cell-free extracts of the bacteria . | NA | {
"id": "C0007367",
"name": "catalase",
"pos": [
104,
112
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
119,
130
]
} |
[ clinical study of a phytosterol extract of prunus arborea and 3 amino acids : glycine , alanine and glutamic acid ] . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
66,
77
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
80,
87
]
} |
[ clinical study of a phytosterol extract of prunus arborea and 3 amino acids : glycine , alanine and glutamic acid ] . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
66,
77
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
90,
97
]
} |
on the other hand the comparison between urinary data of 3-mt and da in normal infants and adult subjects has shown that 3-mt excretion is less affected by dietary input than da itself , so that it can be concluded that urinary 3-mt is a better indication of peripheral dopaminergic activity than urinary da , chiefly in the young child . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
270,
282
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
305,
307
]
} |
the activating effect of serum was only slightly reduced in isopropanol-treated rats , whereas it was found unaffected in ethanol-treated ones . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
60,
71
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
122,
129
]
} |
to investigate a possibility of autoimmune regulation in amebiasis , sera of hamsters with experimental amebic liver abscesses were acidified and tested by counter-current-immunoeletrophoresis against untreated autologous sera and amebic antigen . | NA | {
"id": "C0002438",
"name": "amebiasis",
"pos": [
57,
66
]
} | {
"id": "C0023886",
"name": "amebic liver",
"pos": [
104,
116
]
} |
[ present status of the diagnosis and treatment of invasive amebiasis caused by entamoeba histolytica . i. usefulness of ultrasonography in the diagnosis and evolution of amebic liver abscess ] . | NA | {
"id": "C0002438",
"name": "amebiasis",
"pos": [
60,
69
]
} | {
"id": "C0023886",
"name": "of amebic liver abscess",
"pos": [
168,
191
]
} |
the formation of cellulases and beta-glucosidase and their location in the fungus phialophora malorum was studied on some different carbon sources . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
17,
27
]
} | {
"id": "C0005223",
"name": "beta-glucosidase",
"pos": [
32,
48
]
} |
serological cross reaction with lipid a antigen of salmonella minnesota confirmed the presence of lps in c. autotrophicum . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
32,
39
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
98,
101
]
} |
antisera to these synthetic peptidyl-protein antigens contained fairly high amounts of antibodies with specificity to the n-terminal parts of the peptide chains attached to the carrier proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} | {
"id": "C0007292",
"name": "carrier proteins",
"pos": [
177,
193
]
} |
abnormal anterior pituitary ( ap ) responsiveness to acute administration of thyrotropin-releasing hormone ( trh ) and luteinizing hormone-follicle stimulating hormone-releasing hormone ( lh-rh ) was investigated in 14 patients ( two men and 12 women ) suffering from primary affective disorders . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
9,
27
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
77,
88
]
} |
a staining technique is described to differentiate between the various types of cell in the anterior pituitary ( growth hormone and prolactin producing cells , gonadotrophic , thyrotrophic and acty cells ) in dogs , rats and rabbits . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
92,
110
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
113,
127
]
} |
posttraining brain norepinephrine concentrations : correlation with retention performance of avoidance training and with peripheral epinephrine modulation of memory processing . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
19,
33
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
132,
143
]
} |
one form was similar to the isoenzyme found in other extracellular fluids , such as plasma and tears , the other resembled the intracellular ( lysosomal ) enzyme . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
28,
37
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
155,
161
]
} |
on the basis of the chemical and structural features of the amino acid sequences in the vicinities of phosphorylatable hydroxyamino acid residues in several of the well-known protein substrates for skeletal-muscle cyclic amp-dependent protein kinase , it is hypothesized that the phosphorylatable residue at position i and arginine residue at position i-3 of these protein substrates are located on a peptide turn on the hydrophilic protein surface . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
175,
182
]
} | {
"id": "C0025252",
"name": "protein surface",
"pos": [
433,
448
]
} |
a peptide corresponding to residues 83-134 was isolated , which forms a ca ( 2+-dependent complex with troponin i and neutralizes the inhibition by troponin i of the mg ( 2+-stimulated adenosine triphosphatase of desensitized actomyosin . | NA | {
"id": "C0041199",
"name": "complex",
"pos": [
90,
97
]
} | {
"id": "C0077401",
"name": "troponin i",
"pos": [
148,
158
]
} |
the trout lipoproteins have lipid compositions which are similar to those of the corresponding human components , except for their high contents of long-chain unsaturated fatty acids . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
10,
22
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
28,
33
]
} |
even after extensive proteolysis and purification , the compound was associated with small amounts of protein , the major amino acids of which were aspartic acid , threonine , serine , glutamic acid , glycine and valine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
122,
133
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
201,
208
]
} |
identification of histidine-122alpha in human haemoglobin as one of the unknown alkaline bohr groups by hydrogen -- tritium exchange . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
104,
112
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
116,
123
]
} |
human carbonmonoxy- and deoxy-haemoglobins were incubated at 37 degrees c in 3h2o at various ph values to measure the ph-dependent hydrogen -- tritium exchange at the c-2 position of the imidazole ring of histidine-122alpha . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
131,
139
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
143,
150
]
} |
the molar proportions of individual fatty acids in both the triacylglycerol and non-esterified fatty acid fractions did not alter between the arterial and venous samples . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
36,
41
]
} | {
"id": "C0015688",
"name": "non-esterified fatty acid",
"pos": [
80,
105
]
} |
two electrophoretically distinguishable metallothioneins were isolated from the livers of cd2+-treated rats and had thiol group/metal ratios of 3:1 , a total metal content , in each of these proteins , of 3.6 atoms of cd2+ + 2.4 atoms of zn2+/molecule and 4.2 atoms of cd2+ + 2.8 atoms of zn2+/molecule and respective apoprotein mol.wts . of 5844 and 6251 . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
191,
199
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
318,
328
]
} |
two catechol 1,2-dioxygenases , pyrocatechase i and pyrocatechase ii , were found in 3-chlorobenzoate-grown cells of pseudomonas sp . | NA | {
"id": "C0599874",
"name": "dioxygenases",
"pos": [
17,
29
]
} | {
"id": "C0054859",
"name": "pyrocatechase",
"pos": [
52,
65
]
} |
synthesis of coliphage lambda proteins in minicells as a possible tool for the identification of lambda early gene products . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
0,
9
]
} | {
"id": "C0033684",
"name": "gene products",
"pos": [
110,
123
]
} |
three patients with serologic findings of mixed connective tissue disease and extensive gastrointestinal involvement compatible with the changes found in progressive systemic sclerosis are presented . | NA | {
"id": "C0009782",
"name": "of",
"pos": [
39,
41
]
} | {
"id": "C0036421",
"name": "progressive systemic sclerosis",
"pos": [
154,
184
]
} |
catecholamine sensitivity in hyper- and hypothyroidism has been studied using a standardised isoprenaline sensitivity test . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
0,
13
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
93,
105
]
} |
primaquine-mediated oxidation of haemoglobin to methaemoglobin was reduced by the addition of catalase and increased by superoxide dismutase . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
33,
44
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
48,
62
]
} |
on day 0 , one group was started on phenobarbital drinking water and one group stayed on regular acid water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
50,
64
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
102,
107
]
} |
of the two new lactones , spirolactone was the more reactive : this was confirmed by both animal and human testing . | NA | {
"id": "C0022947",
"name": "lactones",
"pos": [
15,
23
]
} | {
"id": "C0037982",
"name": "spirolactone",
"pos": [
26,
38
]
} |
sezary cells in the circulation were counted daily in 14 hospitalized dermatology patients : six with contact dermatitis , five with atopic dermatitis , and three with exfoliative psoriasis . | NA | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
110,
120
]
} | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
133,
150
]
} |
previous users of oral contraceptives were found to have significantly less bleeding before iucd insertion , but showed a similar pattern of increase of uterine bleeding after iucd insertion to those who had not used oral contraceptives . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
76,
84
]
} | {
"id": "C0042134",
"name": "uterine bleeding",
"pos": [
153,
169
]
} |
birth weights were similar for all treatments and live-weight gains of lambs to 56 d of age were improved in all supplemented groups ( p less than 0.05 ) . | NA | {
"id": "C0005612",
"name": "birth weights",
"pos": [
0,
13
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
55,
61
]
} |
percentage stimulation of these enzymes by pre-incubation of extracts with pyridoxal phosphate was minimal with those groups of turbot given 2.5 mg pyridoxine/kg diet or more . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
75,
94
]
} | {
"id": "C0034272",
"name": "diet",
"pos": [
162,
166
]
} |
enzyme induced in the presence of selenomethionine or indospicine showed the largest increases in heat lability , and for these analogues equimolar concentrations of methionine and arginine respectively were needed to nullify the enzyme abnormality . | NA | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
34,
50
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
166,
176
]
} |
breath hydrogen and methane were measured in eight normal individuals after acute and separate administration of different chemical components of dietary fibre . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
7,
15
]
} | {
"id": "C0013879",
"name": "chemical components",
"pos": [
123,
142
]
} |
the substrates included mixed disulfides of glutathione , other low-molecular-weight disulfides , s-sulfocysteine and s-sulfoglutathione , and peptide disulfides such as insulin , oxytocin , ribonuclease , and the mixed disulfide of glutathione and egg-white lysozyme . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
44,
55
]
} | {
"id": "C0061516",
"name": "disulfide",
"pos": [
220,
229
]
} |
the enzyme is stimulated by co2+ 1.65-fold , but , in contrast to the enzyme-zinc complex , the enzyme-cobalt complex dissociates upon dialysis . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
96,
102
]
} |
the lateral-diffusion coefficients ( d ) of a fluorescent lipid analogue , 3,3'-dioctadecylindotricarbocyanine ( dii ) , have been measured in black lipid membranes ( blms ) , in large ( 20 -- 50-micron diameter ) solvent-free bilayer and multilayer membrane vesicles , and in multilamellar liquid crystals of dipalmitoylphosphatidylcholine , dimyristoylphosphatidylcholine , and egg lecithin . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
58,
63
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
149,
154
]
} |
in two series of experiments , one with a kappa chain probe ( mopc 41 mrna ) , the other with a lambda chain probe ( sapc 178 mrna ) , we analyzed a variety of myeloma dnas and krebs dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
40,
41
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
183,
186
]
} |
an equivalent decrease of albumin mrna activity in the hepatoma was detected by translation in a mrna-dependent cell-free protein-synthesizing system . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
26,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
122,
129
]
} |
the reaction with 2-propanol of purines and pyrimidines , induced photochemically with light of lambda greater than 300 nm and di-tert-butyl peroxide as an initiator , was applied to a variety of adenosine- , guanosine- , and uridine-containing ribonucleotides in order to determine the rules which govern the reactivity of the heterocyclic bases of nucleotides . | NA | {
"id": "C0035548",
"name": "ribonucleotides",
"pos": [
245,
260
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
350,
361
]
} |
the spectrum of escherichia coli 5s rna indicates that the stacking efficiency of the guanine bases is much higher in 5s rna than in yeast in phenylalanine transfer rna , while that of the adenine bases is lower . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
36,
39
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
156,
168
]
} |
irradiation of aqueous solutions of escherichia coli 50s ribosomes with 253.7-nm radiation results in the formation of single-strand breaks in double-stranded regions of the 23s rrna component , but not in rrna chain scission , and destabilization of the secondary structure of the 23s rrna toward denaturation . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
178,
182
]
} | {
"id": "C0035704",
"name": "23s rrna",
"pos": [
282,
290
]
} |
free 23s rrna is resistant toward photoinduced chain breakage at doses of 253.7-nm radiation up to at least 2.3 x 10 ( 20 ) and is much less sensitive toward destabilization of secondary structure than ribosome-bound 23s rrna toward chain breakage , 50s ribosome-bound 5s rrna is resistant toward chain breakage at doses of 253.7-nm radiation up to at least 2.3 x 10 ( 20 ) quanta . | NA | {
"id": "C0035704",
"name": "ribosome",
"pos": [
202,
210
]
} | {
"id": "C0035701",
"name": "ribosome",
"pos": [
254,
262
]
} |
the binding and the kinetic data , however , can be fitted by two diametrically opposed models of receptor to enzyme coupling : ( a ) the precouped enzyme-receptor model where activation of the enzyme occurs , according to the following scheme : formula ( see text ) where h is the hormone , re is the precoupled respetor-enzyme complex , k1 and k2 are the rate constants describing hormone binding , and k is the rate constant characterizing the formation of hre ' from the intermediate hre . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
110,
116
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
322,
336
]
} |
the agreement between the results obtained with anionic and cationic amino reactive probes indicates that the ionic character of the reagent has a minor effect on the pattern of labeled exterior polypeptides observed in erythrocytes . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
48,
55
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
110,
115
]
} |
the agreement between the results obtained with anionic and cationic amino reactive probes indicates that the ionic character of the reagent has a minor effect on the pattern of labeled exterior polypeptides observed in erythrocytes . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
60,
68
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
110,
115
]
} |
treatment of dna with osmium tetroxide is known to produce 5,6-dihydroxydihydrothymine which is a minor photoproduct in dna after irradiation , suggesting that the ultraviolet-specific endonuclease activity acts upon this lesion . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
13,
16
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
207,
208
]
} |
the products of hydrolysis are mostly deoxyribonucleoside 5'-monophosphate and no nucleosides are released into the acid-soluble fraction . | NA | {
"id": "C0011528",
"name": "deoxyribonucleoside",
"pos": [
38,
57
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
82,
93
]
} |
upon irradiation of an enzyme-trna complex , almost no covalent binding of trna occurred during enzyme inactivation , suggesting that the histidyl residues involved in the enzymic activity are not required for trna binding . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
23,
29
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
96,
102
]
} |
similar levels of competition with hg-rna transcripts for `` '' unique '' '' dna were obtained using oviduct nuclear rnas isolated before or after estrogen withdrawal , and even with liver nuclear rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035700",
"name": "nuclear r",
"pos": [
109,
118
]
} |
this is similar to the torsional angles observed for 6-azapyrimidine and 8-azapurine nucleosides , but in marked contrast to those found in uridine , 3-deazauridine and other pyrimidine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
85,
96
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
175,
197
]
} |
this is similar to the torsional angles observed for 6-azapyrimidine and 8-azapurine nucleosides , but in marked contrast to those found in uridine , 3-deazauridine and other pyrimidine nucleosides . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
140,
147
]
} | {
"id": "C0000399",
"name": "3-deazauridine",
"pos": [
150,
164
]
} |
this is similar to the torsional angles observed for 6-azapyrimidine and 8-azapurine nucleosides , but in marked contrast to those found in uridine , 3-deazauridine and other pyrimidine nucleosides . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
140,
147
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
175,
197
]
} |
differentiated thermal melting profiles were made of all the three rna species ( rnas 1 , 2 and 3 ) , constituting the genome of alfalfa mosaic virus and of the subgenomic coat protein messenger rna ( rna 4 ) of this virus . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
185,
198
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
201,
204
]
} |
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