text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
an improved purification method of the sheep kidney nuclease ( nuclease sk ) specific for single-strans nucleic acid , which includes extraction with 0.85 % nacl , treatment with deae-cellulose , fractionation with polyethylene glycol , phospho-cellulose chromatography , cm-sephadex chromatography and phospho-cellulose rechromatography is described . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
179,
193
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
311,
320
]
} |
the gamma-dna forms a homogeneous dense band that contains all the rdna , and the amount of gamma-dna estimated from the gradients can be correlated to amount of rdna derived from rrna-dna hybridizations . | NA | {
"id": "C0012933",
"name": "rdna",
"pos": [
67,
71
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
185,
188
]
} |
the design and use of iron ( iii ) chelates in the oral treatment of iron-deficiency anemia is discussed in terms of the following criteria : ( 1 ) the ability of a chelate to exist as a monomeric species even at physiological ph values , ( 2 ) the rate of transfer of iron from the chelate to the iron-transporting protein-apotransferrin , ( 3 ) the rate of depolymerization of ferric citrate polymer by the free ligand , and ( 4 ) its nontoxicity and ability to regenerate hemoglobin levels in anemic rats . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
22,
26
]
} | {
"id": "C0060231",
"name": "ferric citrate",
"pos": [
379,
393
]
} |
histone hl shows a preferential affinity for high molecular weight dna in comparison with sonicated dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
17,
18
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
100,
103
]
} |
after analyzing its substrate specificity , its ph dependence in relation to different substrates , its kinetic properties , as well as its behaviour towards ascorbic acid and different inhibitors ( sodium tungstate and sodium molybdate , l-tartrate , l-phenylalanine and l-cysteine ) we have come to the conclusion that the rat spleen app-ase is different from `` '' nonspecific '' '' acid and alkaline phosphatases and very similar to the ec 3.1.3.16 acid phosphoprotein phosphatase . | NA | {
"id": "C0031686",
"name": "app-ase",
"pos": [
336,
343
]
} | {
"id": "C1956003",
"name": "3",
"pos": [
448,
449
]
} |
among 9 amino acids studied alanine , methionine , lysine , tyrosine and arginine are not incorporated into the system in question . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
8,
13
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
28,
35
]
} |
the interrelationship between nuclear rnp particles and chromatin in zajdela hepatoma cells double labelled with 3h-thymidine and 14c-uridine was investigated by three independent methods ( nucleoprotein-celite chromatography , sucrose density and cscl band centrifugations ) . | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
56,
65
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
190,
203
]
} |
cleavage of different dna forms ( superhelical dna i , relaxed circular dna ii and linear dna iii ) is described by the kinetic equations of the first order , and respective rate constants k1 , k2 , and k3 are determined at all salt concentrations used . | NA | {
"id": "C0012937",
"name": "superhelical dna",
"pos": [
34,
50
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
63,
75
]
} |
cleavage of different dna forms ( superhelical dna i , relaxed circular dna ii and linear dna iii ) is described by the kinetic equations of the first order , and respective rate constants k1 , k2 , and k3 are determined at all salt concentrations used . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
63,
75
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
90,
93
]
} |
in all dnas studied 5-methylcytosine is unevenly distributed in pyrimidine isopliths : the degree of cytosine methylation [ m5c ( c+m5c ) ] is decreased with an increase in the length of isopliths , irrespective of the ratio of thymine and cytosine residues . | NA | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
20,
36
]
} | {
"id": "C0010843",
"name": "cytosine",
"pos": [
240,
248
]
} |
in mature newborn infants , 7 ( ala , lys , leu , val , ile , phe and his ) of the 20 plasma amino acids were significantly higher and 4 ( glu , gly , ser and orn ) were significantly lower in the umbilical vein than in the umbilical artery . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
93,
104
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
145,
148
]
} |
the effects of maternal methadone ( 5 mg/kg methadone-hcl ) administration during gestation and/or lactation on gross body measurements , absolute organ weights , dry weights , and tissue water content were studied in 21-day-old sprague-dawley rats . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
24,
33
]
} | {
"id": "C0721688",
"name": "methadone-hcl",
"pos": [
44,
57
]
} |
since the biological effects of carrageenan were reviewed in 1972 by di rosa it has become clear from a large number of reports that this algal polysaccharide markedly influences immune responses . | NA | {
"id": "C0007289",
"name": "carrageenan",
"pos": [
32,
43
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
144,
158
]
} |
the hyperlipemia appears 20 hours after the injection and consists in a hypertriglyceridaemia as suggested by the enrichment of serum in very light lipoproteins of density about 1.006 . | NA | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
4,
16
]
} | {
"id": "C0020557",
"name": "hypertriglyceridaemia",
"pos": [
72,
93
]
} |
localization of two phospholipid haptens -- cardiolipin and phosphatidylinositol -- in mouse liver sections was studied by the indirect method of fluorescent antibodies . | NA | {
"id": "C0018593",
"name": "haptens",
"pos": [
33,
40
]
} | {
"id": "C0007188",
"name": "cardiolipin",
"pos": [
44,
55
]
} |
two hundred strains of staphylococcus aureus isolated from outpatients with infections of the skin and subcutaneous tissues were tested for sensitivity to penicillin , erythromycin , tetracycline , sodium fusidate , methicillin , clindamycin , chloramphenicol , and gentamicin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
155,
165
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
216,
227
]
} |
the children were classified into three groups-namely , those with anoxic fcs , those with epileptic fcs , and `` '' others '' '' -according to the appearances of the fc and the electroencephalogram ( eeg ) . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
91,
100
]
} | {
"id": "C0009952",
"name": "e",
"pos": [
2,
3
]
} |
because formaldehyde fixes free amino acids poorly , much of the glycine taken up by r3-r14 is , therefore , not incorporated into protein . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
32,
43
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
65,
72
]
} |
the action of nicotine was prevented by pretreatment with the da receptor blocking agent , pimozide ( 5 mg/kg ) , which indicates ( 1 ) that a dopaminergic mechanism was involved in the nicotine effect and ( 2 ) that the tanycyte response was elicited by da released from nerve terminals acting at some receptor site . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
143,
155
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
255,
257
]
} |
butorphanol tartrate or morphine sulphate were then employed during maintenance of anaesthesia in repeated intravenous doses , averaging butorphanol 4.6 mg and morphine 22.8 mg per patient . | NA | {
"id": "C0700525",
"name": "butorphanol tartrate",
"pos": [
0,
20
]
} | {
"id": "C0006491",
"name": "butorphanol",
"pos": [
137,
148
]
} |
butorphanol tartrate or morphine sulphate were then employed during maintenance of anaesthesia in repeated intravenous doses , averaging butorphanol 4.6 mg and morphine 22.8 mg per patient . | NA | {
"id": "C0066814",
"name": "morphine sulphate",
"pos": [
24,
41
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
160,
168
]
} |
if this hypothesis is valid , isozymes and allozymes should represent alternative forms of enzyme adaptation and the levels of the two types of variation should be negatively correlated . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
30,
38
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
91,
97
]
} |
competition with 17beta-estradiol at the cytosol receptor sites was observed in four of the six derivatives tested , namely trans- and cis-zearalenone , zearalenol , and zearalanol . | NA | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
139,
150
]
} | {
"id": "C0043465",
"name": "zearalanol",
"pos": [
170,
180
]
} |
similarly , long-term diets enriched with pyridoxine and pyridoxal phosphate did not significantly improve the efficiency of the injected holoenzyme . | NA | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
42,
52
]
} | {
"id": "C0034266",
"name": "pyridoxal",
"pos": [
57,
66
]
} |
while the corticoid-resistant line also demonstrates an effect of similar magnitude , it requires a much longer exposure to the hormone ( 6 hr ) . | NA | {
"id": "C0001617",
"name": "corticoid",
"pos": [
10,
19
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
128,
135
]
} |
a basic difference in response between normal cells ( primate fibroblasts ) and colonic cancer cells ( human and rodent ) to the antiproliferative action of both n- ( phosphonacetyl ) -l-aspartate and thymidine is described in this report . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
95,
100
]
} |
the qualitatively similar , but much stronger , carcinogenic activity of vinyl carbamate as compared to that of ethyl carbamate suggests that the metabolic pathways of these two carbamates may converge in the formation of similar or identical electrophilic reactants that bind covalently to macromolecules in vivo and initiate carcinogenesis . | NA | {
"id": "C0041964",
"name": "ethyl carbamate",
"pos": [
112,
127
]
} | {
"id": "C0006948",
"name": "carbamates",
"pos": [
178,
188
]
} |
a phorbol ester promoting agent , 12-o-tetradecanoylphorbol-13-acetate , enhances plasminogen activator production in hamster cell lines that synthesize plasminogen activator immunologically identical with plasminogen activator of normal hamster lung cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
2,
15
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
34,
70
]
} |
this is the same size as the estrogen-induced peroxidase of rat uterus but smaller than other mammalian peroxidases . | NA | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
46,
56
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
104,
115
]
} |
although it is likely that a certain fraction of the nuclear bound receptor-estrogen complex exists as a ternary high-affinity acceptor-receptor-estrogen complex , current salt extraction procedures do not allow discrimination between receptor-17beta-estradiol complexes associated with high-affinity and low-affinity nuclear binding sites . | NA | {
"id": "C0034804",
"name": "receptor-estrogen",
"pos": [
67,
84
]
} | {
"id": "C0034803",
"name": "receptor-17beta-estradiol",
"pos": [
235,
260
]
} |
when g1 cells that have been arrested by bt2camp are grown in fresh medium free of bt2camp , they begin to reenter s phase after a delay of about 6 hr and do so with pseudo-first-order kinetics , with a half-life of 5 hr . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
185,
193
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
203,
212
]
} |
in this series of patients , the tumors containing both estradiol and progesterone receptors were stimulated by addition of insulin and estradiol while the tumors containing either estradiol receptor alone or no steroid receptor were not modified by hormonal addition . | NA | {
"id": "C0034833",
"name": "progesterone receptors",
"pos": [
70,
92
]
} | {
"id": "C0034840",
"name": "steroid receptor",
"pos": [
212,
228
]
} |
both myeloma antidextrans were alphad- ( 1 leads to 6 ) specific and precipitated strongly with a synthetic , linear dextran , molecular weight 35,500 , and with other dextrans . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
17,
24
]
} | {
"id": "C0011806",
"name": "dextrans",
"pos": [
168,
176
]
} |
the fructan-specific myeloma protein did not react with inulin , but reacted with many levans and with perennial rye-grass levan containing only beta-d- ( 2 leads to 6 ) links . | NA | {
"id": "C0021936",
"name": "inulin",
"pos": [
56,
62
]
} | {
"id": "C0016743",
"name": "levans",
"pos": [
87,
93
]
} |
vasopressin and oxytocin pathways were specifically localized in glutaraldehyde-paraformaldehyde fixed rat brains , with the use of the unlabelled antibody enzyme method and purification of the first antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
147,
155
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
200,
209
]
} |
autoradiography indicated that the labeling index was initially high in fibroblasts and osteoblasts but was subsequently reduced while it increased in osteocytes , cells of haversian canals , stromal and hemopoietic cells of marrow . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
216,
221
]
} |
the structure of the hb lepore gene is shown to be a fused delta -- and beta-globin gene , and to be completely consistent with the derived map of normal beta -- and delta-globin genes . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
72,
83
]
} | {
"id": "C0011244",
"name": "delta-globin",
"pos": [
166,
178
]
} |
at high cell densities , however , small numbers of two other cell types are formed , which respectively resemble secretory and myoepithelial cells of the mammary gland , as judged by light and electron microscopy and immunofluorescent staining for casein ( milk proteins ) . | NA | {
"id": "C0007332",
"name": "casein",
"pos": [
249,
255
]
} | {
"id": "C0026138",
"name": "milk proteins",
"pos": [
258,
271
]
} |
this has enabled us to determine the messenger rna ( mrna ) sequence beginning in the 5 ' untranslated region 9 nucleotides before the initiation codon and extending through the first 361 nucleotides of the translated region . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
37,
50
]
} | {
"id": "C0600680",
"name": "untranslated region",
"pos": [
90,
109
]
} |
the precipitated nucleoprotein contained expected amounts of dna and a protein analogous to mammalian histone h1 . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
17,
30
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
71,
78
]
} |
the separation of deoxyribonucleosides and the two etheno-deoxyribosyl-nucleosides by liquid chromatography , and the mass spectra of etheno-deoxyadenosine and etheno-deoxycytidine and of their o-bis- ( trimethylsilyl ) derivatives are described . | NA | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
18,
38
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
71,
82
]
} |
imidazo- [ 2,1-i ] purine ( etheno-adenine ) is identified : ( a ) in the supernatant after sedimentation of the modified dna in the model experiment ( i ) , and ( b ) in the product resulting from the reaction between chloroacetaldehyde and deoxyadenosine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
19,
25
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
35,
42
]
} |
in general , each test substance showed distinctive actions suggesting that the effects of the metal chelates are mediated by the intact chelate cation and not by liberated metal ion or ligand . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
145,
151
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
179,
182
]
} |
the results were discussed in relation to an existing model in which it was postulated that a dna replication dependent repair mechanism enables cells to replicate dna using a cis-pt ( ii ) damaged dna template . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
92,
97
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
198,
201
]
} |
the aminoalkylphosphonyl cerebroside fraction consisted of a major portion of 1-o- [ 6'-o- ( n-methylaminoethylphosphonyl ) galactosyl ] ceramide and a minor portion of a novel lipid , 1-o- [ 6'-o- ( aminoethylphosphonyl ) galactosyl ] ceramide . | NA | {
"id": "C0007805",
"name": "cerebroside",
"pos": [
25,
36
]
} | {
"id": "C0016960",
"name": "galactosyl",
"pos": [
223,
233
]
} |
chemical structure of these molecules is very important : sulfur atom ( phenothiazine , thioxanthene ) , some substituants like chlorine ( chlorpromazine , chlorprothixene ) and 2'-dimethylaminopropyl chain ( promethazine ) increase this inductive effect . | NA | {
"id": "C0039961",
"name": "thioxanthene",
"pos": [
88,
100
]
} | {
"id": "C0008290",
"name": "chlorprothixene",
"pos": [
156,
171
]
} |
this study has introduced a technique that can provide a qualitative assessment of the relationship between ecg evidence of ischemia and infarction in each patient . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
124,
132
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
137,
147
]
} |
ammonia was used as the reagent gas , which gives rise to few but specific sample-fragment ions , such as ( m -- 1 ) - as the base peak , m/z 91 , and a smaller peak corresponding to the end part of the side chain . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
0,
7
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
32,
35
]
} |
recovery of the enzyme in the eluted fractions averaged 102 % ( sd , 2.0 % ) for specimens prepared from the purified isoenzymes and 104 % ( sd , 10.7 % ) for 38 human serum specimens . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
16,
22
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
118,
128
]
} |
results of these uric acid analyses by use of immobilized uricase , in conjunction with peroxidase ( ec 1.11.1.7 ) and aminophenazone-dichlorophenol in solution , are compared with those obtained with the same enzyme in solution by use of the uricase-pap ( peroxidase , 4-aminophenazone , dichlorophenol ) method . | NA | {
"id": "C0030016",
"name": "ec 1",
"pos": [
101,
105
]
} | {
"id": "C0041931",
"name": "uricase",
"pos": [
243,
250
]
} |
results of these uric acid analyses by use of immobilized uricase , in conjunction with peroxidase ( ec 1.11.1.7 ) and aminophenazone-dichlorophenol in solution , are compared with those obtained with the same enzyme in solution by use of the uricase-pap ( peroxidase , 4-aminophenazone , dichlorophenol ) method . | NA | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
119,
133
]
} | {
"id": "C0002696",
"name": "4-aminophenazone",
"pos": [
270,
286
]
} |
ethosuximide is extracted from acidified plasma or serum into chloroform containing an internal standard alpha , alpha-dimethyl-beta-methyl succinimide . | NA | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
0,
12
]
} | {
"id": "C0038623",
"name": "succinimide",
"pos": [
140,
151
]
} |
simultaneous gas-chromatographic analysis for diazepam and its major metabolite , desmethyldiazepam , with use of double internal standardization . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
46,
54
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
82,
99
]
} |
electron-capture gas-liquid chromatography was used for simultaneous quantitation of plasma diazepam ( i ) and its major metabolite , desmethyldiazepam ( ii ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
92,
100
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
134,
151
]
} |
variation of trace binding in digoxin radioimmunoassay by use of 125i-labeled 3-o-succinyl-digoxigenin : relation of thyroxine concentration to binding . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
30,
37
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
91,
102
]
} |
the presence of cetyltrimethylammonium bromide at adequate concentration allowed complete ether extraction of phospholipids from lipoprotein-x even at low concentration , without affecting the phospholipids of normal lipoproteins . | NA | {
"id": "C0023819",
"name": "lipoprotein-x",
"pos": [
129,
142
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
217,
229
]
} |
the testing of the type of membrane associated alkaline phosphatase ( ec 3.1.3.1 ) by immunotitration has revealed that there is a shift from a liver-like type of alkaline phosphatase in normal cell cultures of the human diploid fibroblast cell strains wi 26 and wi 38 to a placenta-like variant in cultures of the same cell strains after the transformation by the dna-tumor virus sv 40 , the wi 26 sv 40 and the wi 38 sv 40 cell lines . | NA | {
"id": "C0007634",
"name": "normal cell",
"pos": [
187,
198
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
229,
239
]
} |
the intracellular copper concentration of mkhd cells was significantly higher than that of normal fibroblasts at medium copper concentrations below 20 microgram/ml . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} |
serum concentrations of oestradiol , pregnenolone , progesterone , 17alpha-hydroxyprogesterone , androstenedione , testosterone , 5alpha-dihydrotestosterone and androsterone were determined from a single serum sample ( 1.6 ml ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
52,
64
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
67,
94
]
} |
nonsuppressible insulin-like activity ( nsila ) consists of a number of factors mimicking insulin activity which compete with insulin or proinsulin for membrane receptors and may crossreact in bioassays , immunoassays , and receptor assays . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
16,
23
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
137,
147
]
} |
the association of taurodontism with hypoplastic/hypomature enamel defects is presented in two cases of x-chromosome aneuploidy ( 47 , xxy ) and one of x-linked recessive amelogenesis imperfecta . | NA | {
"id": "C0011351",
"name": "hypoplastic",
"pos": [
37,
48
]
} | {
"id": "C0002452",
"name": "amelogenesis imperfecta",
"pos": [
171,
194
]
} |
these results therefore suggest that levodopa , via its decarboxylated metabolites , dopamine , noradrenaline and adrenaline , may produce or exacerabate tremor in man . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
114,
124
]
} |
racemic mixtures of noradrenaline , adrenaline , isoprenaline , n-t-butylnor-adrenaline and their corresponding derivatives containing an oxymethylene ( om ) link between the phenyl ring and ethanolamine side-chain have been tested for their effects on beta-adrenoceptors in isolated guinea-pig atrial and tracheal preparations . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
20,
33
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} |
conceivably saralasin exerts different sodium-dependent effects on peripheral angiotensin ii and specific intrarenal vascular receptors . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
12,
21
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
78,
92
]
} |
the study indicates that arterial pressure is not dependent on angiotensin ii in sodium replete patients and in sodium deplete subjects with low prc , while it is angiotensin dependent during sodium depletion in the others . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
63,
77
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
163,
174
]
} |
the initial effect is release of prostaglandin ( probably pge ) and this leads to release of kallikrein . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
33,
46
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
58,
61
]
} |
these results indicate that the natriuresis and antihypertensive effect of furosemide in vivo , which is associated with a significant increase in urinary pge2 , is not the result of a direct stimulation of furosemide on prostaglandin synthesis but may result from a decrease in pge metabolism , conversion to another biologically active prostaglandin or possibly be a reflection of events secondary to a direct effect of furosemide on renal hemodynamics and electrolyte excretion . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
155,
159
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
279,
282
]
} |
these results indicate that the natriuresis and antihypertensive effect of furosemide in vivo , which is associated with a significant increase in urinary pge2 , is not the result of a direct stimulation of furosemide on prostaglandin synthesis but may result from a decrease in pge metabolism , conversion to another biologically active prostaglandin or possibly be a reflection of events secondary to a direct effect of furosemide on renal hemodynamics and electrolyte excretion . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
155,
158
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
338,
351
]
} |
these results indicate that the natriuresis and antihypertensive effect of furosemide in vivo , which is associated with a significant increase in urinary pge2 , is not the result of a direct stimulation of furosemide on prostaglandin synthesis but may result from a decrease in pge metabolism , conversion to another biologically active prostaglandin or possibly be a reflection of events secondary to a direct effect of furosemide on renal hemodynamics and electrolyte excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
283,
293
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
471,
480
]
} |
effects of drinking hot water , cold water , and chicken soup on nasal mucus velocity and nasal airflow resistance . | NA | {
"id": "C0599638",
"name": "drinking",
"pos": [
11,
19
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
37,
42
]
} |
nasal mucus velocity and nasal airflow resistance were measured in 15 healthy subjects before and at 5 and 30 minutes after drinking hot water by sip or straw , hot chicken soup by sip or straw , and cold water by sip . | NA | {
"id": "C0599638",
"name": "drinking",
"pos": [
124,
132
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
205,
210
]
} |
this may be attributed to unaltered protein binding of the drug in undernourished subjects in spite of low serum albumin levels , since streptomycin binds to globulins , in addition to albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
36,
43
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
158,
167
]
} |
this may be attributed to unaltered protein binding of the drug in undernourished subjects in spite of low serum albumin levels , since streptomycin binds to globulins , in addition to albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
36,
43
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
185,
192
]
} |
in vitro activity of carbenicillin , ticarcillin , sisomicin and netilmicin alone and in combination against pseudomonas aeruginosa . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
51,
60
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
65,
75
]
} |
the in vitro activity of carbenicillin , ticarcillin , sisomicin and netilmicin alone and in combination against 35 strains of pseudomonas aeruginosa was investigated . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
55,
64
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
69,
79
]
} |
there was enhanced killing of many strains of p. aeruginosa by the combination of carbenicillin or ticarcillin with sisomicin or netilmicin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
116,
125
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
129,
139
]
} |
no similar case of relatively benign idiopathic megacolon complicated by pseudomembranous colitis and toxic megacolon has been reported . | NA | {
"id": "C0025160",
"name": "idiopathic megacolon",
"pos": [
37,
57
]
} | {
"id": "C0025162",
"name": "toxic megacolon",
"pos": [
102,
117
]
} |
the autosomal dominant hereditary syndrome of symphalangism and stapes fixation consists of multiple synostoses , most frequently symphalangism , in addition to synostoses of carpal and tarsal bones and radio-ulnar synostoses , various other malformations of the limbs ( restricted joint movement or syndactylism ) and variable degrees of conduction disorders due to stapes fixation , starting in childhood . | NA | {
"id": "C0206762",
"name": "malformations of the limbs",
"pos": [
242,
268
]
} | {
"id": "C0039075",
"name": "syndactylism",
"pos": [
300,
312
]
} |
the films , prepared on cef2 plates were recorded before and after 30 minutes treatment with methanol , ethyl and isopropil alcohol respectively . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
93,
101
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
124,
131
]
} |
after treatment of the films for a period of 30 minutes with methanol , ethyl or isopropil alcohol there were changes , which manifested beta structures in young erythrocytes around 31 % and in old erythrocytes around 30 % of the intensity of the total absorption of the membrane proteins . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
61,
69
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
91,
98
]
} |
lipid a was isolated from lipopolysaccharide of yersinia pseudotuberculosis s form ( strain 341 , subtype ib ) using mild hydrolysis with acetic acid . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
0,
7
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
26,
44
]
} |
dodecanoic and 3-hydroxy-tetradecanoic acids in a molar ratio of 1 : 3.6 were detected as major fatty acid constituents . | NA | {
"id": "C0027139",
"name": "tetradecanoic acids",
"pos": [
25,
44
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
96,
106
]
} |
in six infants aged between 4 and 8 months with chronic renal failure , we have studied blood levels of calcium ( ca ) , phosphorus ( p ) , alkaline phosphatase , immunoreactive parathyroid hormone ( pth ) , and calcitonin ( ct ) , as well as urinary excretion of ca , p , hydroxyproline and cyclic amp under basal conditions and during an infusion of 20 mg/kg of 10 % ca gluconate in normal saline over 4 h . | NA | {
"id": "C0006675",
"name": "ca",
"pos": [
104,
106
]
} | {
"id": "C0006699",
"name": "ca gluconate",
"pos": [
369,
381
]
} |
noradrenaline excretion was normal but that of adrenaline was augmented in a vast majority of patients and even doubled in 27 % of cases . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} |
in hypertriglyceridaemic subjects lcat activity correlated with the concentrations of d less than 1.006 lipoproteins , plasma triglycerides , cholesterol and cholesterol esters and phospholipid levels . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
142,
153
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
158,
176
]
} |
the mechanism of adjuvant activity of the synthetic glycopeptide n-acetylmuramul-l-alanyl-d-isoglutamine or muramyl dipeptide ( mdp ) was studied using in vitro plaque-forming cell ( pfc ) response to sheep erythrocytes ( srbc ) . | NA | {
"id": "C0017953",
"name": "glycopeptide",
"pos": [
52,
64
]
} | {
"id": "C0001060",
"name": "muramyl dipeptide",
"pos": [
108,
125
]
} |
an anti-type i if serum neutralized if in supernatants from con a-stimulated spleen cells but did not affect mif in the same supernatants . | NA | {
"id": "C0021743",
"name": "type i if",
"pos": [
8,
17
]
} | {
"id": "C0021747",
"name": "if",
"pos": [
110,
112
]
} |
the mechanism of interaction between prednisolone-3,20-bisguanylhydrazone ( pbgh ) and na+ , k+-atpase ( atp phosphohydrolase , ec 3.6.1.3 ) was studied using partially purified rat brain enzyme preparations . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
87,
89
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
105,
125
]
} |
their effects were compared with those of dopamine and apomorphine on neurones of the frontal cortex and of the caudate nucleus both of which are rich in dopaminergic terminals . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
42,
50
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
154,
166
]
} |
( +/- ) -3h-epinephrine and ( - ) -3h-norepinephrine bind to rat cortex membranes in a saturable manner with dissociation constants of 16.7 and 27 nm respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} |
[ effect of adrenaline , noradrenaline , histamine and acetylcholine on the blood flow in the vascular bed of the bone marrow ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
12,
22
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} |
medullary circulation in the tibia and effect produced on it by microinjections of epinephrine ( 1.4.10 ( -5 ) and 2.7.10 ( -5 ) m ) , norepinephrine ( 0.2.10 ( -4 ) m ) , histamine ( 0.9.10 ( -4 ) and 1.8.10 ( -4 ) m ) and acetylcholine ( 2.2.10 ( -4 ) were studies in acute tests on wistar rats by using the 133xe clearance method . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
83,
94
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
135,
149
]
} |
the capacity of 25 different amidines , guanidines and biguanidines to suppress the thrombocytes aggregation , induced by adenosinodiphosphate , was studied . | NA | {
"id": "C0002483",
"name": "amidines",
"pos": [
29,
37
]
} | {
"id": "C0018320",
"name": "guanidines",
"pos": [
57,
67
]
} |
introduction to rats of inactivated ( at 56 degrees c for 30 minutes ) serum of patients with diabetes mellitus that contained antibodies to bucarban or adebit as well as immune rabbit sera greatly mitigated the hypoglycemic effect of the latter . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
127,
137
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
171,
177
]
} |
by using fluorescent probes it was shown that hydrocortisone , cortisone and estron decrease the constant of the probe binding with dimethylaminochalcone in the lipid membranes proportional to the distribution coefficient of steroids in the system lipids-water . | NA | {
"id": "C0025249",
"name": "lipid membranes",
"pos": [
161,
176
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
248,
254
]
} |
the regulation of the photometabolism of provitamin d3 to vitamin d3 , the role and significance of the side-chain metabolism of 1,25 ( oh ) 2d by the small intestine , and the metabolism of 25-oh-d to 24r,25 ( oh ) 2d by chondrocytes and its stimulation of protein synthesis in these cells are just a few issues that will require further investigation . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
222,
234
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
285,
290
]
} |
permeability determinations in the leaky junctions of gallbladder epithelium , using many different organic cations , suggest that the critical barriers barriers to ion permeation are 5 -- 8 a in radius and bind cations by up to four strongly proton-accepting oxygens . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
23,
26
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
212,
219
]
} |
reproductive intentions of white mothers with no more than three children in 1965 and in 1970 were analyzed for their stability and change with respect to such factors as parity , age of the youngest child , wife 's employment , and husband 's education . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
65,
73
]
} | {
"id": "C0728836",
"name": "of",
"pos": [
184,
186
]
} |
parity and age of the youngest child were found to have a much more important effect on the intent to have additional children than were such socioeconomic variables as wife 's employment and husband 's education . | NA | {
"id": "C0728836",
"name": "of",
"pos": [
15,
17
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
118,
126
]
} |
after absorption with heterologous influenza b virus , the cross-reacting antibodies were removed and the ha1 antisera then possessed antibodies which reacted only with the cross-reactive ( cr ) determinants of the ha of the homologous influenza a virus and viruses of the same subtype . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
110,
118
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
134,
144
]
} |
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