text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
netilmicin , a semisynthetic derivative of sisomicin , was tested against 327 isolates of staphylococcus aureus , pseudomonas aeruginosa and gram-negative enteric bacilli . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
0,
10
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
43,
52
]
} |
a comparison of the antibiotic activities of sisomicin , gentamicin and aminosidine sulphate against pseudomonas aeruginosa . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
45,
54
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
57,
67
]
} |
sisomicin , gentamicin and aminosidine sulphate were compared for their antibiotic activity against pseudomonas strains freshly isolated from clinical material . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
0,
9
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
12,
22
]
} |
neoplasms can be detected with a high rate of accuracy , and by assessing the presence of ascites or metastatic foci in the liver , ultrasound can aid in the staging of the neoplastic process . | NA | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
0,
9
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
173,
191
]
} |
steatorrhea , sugar malabsorption , dehydration , and acidosis were severe in all patients , whatever the diet fed . | NA | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
0,
11
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
20,
33
]
} |
binding of cyclic 3h -- nucleotide could not be described as a simple bimolecular reaction and native cyclic nucleotides accelerated the dissociation of bound , labeled cyclic nucleotide . | NA | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
102,
120
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
176,
186
]
} |
both procaine and xylocaine remarkably inhibited the lipolyses caused by norepinephrine , epinephrine , caffeine and theophylline . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
73,
87
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} |
[ salivary gland diseases . clinical aspects , diagnosis , therapy . part 4. therapy ( congenital malformations , inflammatory salivary gland diseases , sialadenitis , sialolithiasis , therapy -- recommendations for oral hygiene care , saliva-stimulating drugs ) ] . | NA | {
"id": "C0036093",
"name": "salivary gland diseases",
"pos": [
2,
25
]
} | {
"id": "C0037023",
"name": "sialadenitis",
"pos": [
153,
165
]
} |
infection of cells of the ebv-genome-negative human b-lymphoma ramos line with viral isolates obtained from two ebv-transformed marmoset cell lines ( b95/8 ; nyevu ) resulted in the induction of a nuclear antigen ( ram-ag ) apparently different from other ebv-associated antigen complexes . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
197,
212
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
271,
278
]
} |
human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal , hyperplastic and neoplastic human breast tissue . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
92,
97
]
} |
during once-daily ingestion of 50 mg of cdx.hcl , observed values of cdx accumulation half-life ( 0.0 , 5.8 , and 52.5 hours ) differed substantially from values predicted based upon the single-dose study ; | NA | {
"id": "C0700528",
"name": "cdx.hcl",
"pos": [
40,
47
]
} | {
"id": "C0008188",
"name": "cdx",
"pos": [
69,
72
]
} |
lumbotomy carried out because of nephrolithiasis makes possible a precise evaluation of the kidney condition and early discovery of tumour producing no clinical symptoms or x-ray changes . | NA | {
"id": "C0392525",
"name": "nephrolithiasis",
"pos": [
33,
48
]
} | {
"id": "C0022658",
"name": "of",
"pos": [
129,
131
]
} |
responses of isolated rabbit ear arteries to intra- and extraluminal l- and d-noradrenaline , l-adrenaline and histamine in the temperature range 37-3 degrees c . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
78,
91
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} |
decorporation from beagles of a mixture of monomeric and particulate plutonium using ca-dtpa and zn-dtpa : dependence upon frequency of administration . | NA | {
"id": "C0520458",
"name": "ca-dtpa",
"pos": [
85,
92
]
} | {
"id": "C0013254",
"name": "dtpa",
"pos": [
100,
104
]
} |
hemoglobin hoshida ( beta43 ( cd-2 ) glu leads to gln ) , a new hemoglobin variant discovered in japan . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
37,
40
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
50,
53
]
} |
structural studies of this abnormal hemoglobin demonstrated a previously undescribed substitution of beta43 ( cd-2 ) glu leads to gln . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
117,
120
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
130,
133
]
} |
an abnormal , fast moving hemoglobin was noted in a 34-yr-old male patient living in legnano ( northern italy ) affected with renal failure and iron deficiency anemia , not related to the presence of the hb variant . | NA | {
"id": "C0019047",
"name": "abnormal",
"pos": [
3,
11
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
204,
206
]
} |
in the test prior to training , plasma epinephrine increased to 0.5 ng/ml and norepinephrine increased to 3.0 ng/ml . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
39,
50
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
78,
92
]
} |
the major proportion of the training-induced decrement in catecholamine response was reached at the end of the 3rd wk when epinephrine increased to 0.17 ng/ml and norepinephrine increased to 1.5 ng/ml in response to the same test . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
163,
177
]
} |
the pha measured during this phase was duplicated during the later continuous infusion of nahco3 at which time either 1 ) ventilation was held constant at the control level , allowing arterial carbon dioxide tension ( paco2 ) to rise as a consequence of the bicarbonate dissociation , or 2 ) paco2 was held constant by s... | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
90,
96
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
258,
269
]
} |
mean intra-arterial pressure ( p- ) , heart rate ( hr ) , cardiac index ( ci ) , total peripheral resistance index ( tpri ) , and plasma renin activity ( pra ) , norepinephrine ( pne ) , and epinephrine ( pe ) were estimated in five normal male subjects placed on a low-sodium diet for the previous 7 days . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
162,
176
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
191,
202
]
} |
acidosis , which results from fecal bicarbonate loss , lactic acidosis , and renal dysfunction , results in tissue buffering , which in turn causes the efflux of cellular potassium ions . | NA | {
"id": "C0001122",
"name": "acidosis",
"pos": [
0,
8
]
} | {
"id": "C0001125",
"name": "lactic",
"pos": [
55,
61
]
} |
glucosamine-containing sphingoglycolipids were isolated from sheep erythrocyte membranes , and the presence of glycolipids with long carbohydrate chains was demonstrated . | NA | {
"id": "C0017978",
"name": "sphingoglycolipids",
"pos": [
23,
41
]
} | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
111,
122
]
} |
the interaction between basic nuclear proteins and dna is discussed in the light of the basic region in protamine and histone molecules . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
30,
46
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
104,
113
]
} |
the interaction between basic nuclear proteins and dna is discussed in the light of the basic region in protamine and histone molecules . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
30,
46
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
118,
125
]
} |
it was found that anions ( chloride , bromide , and nitrate ions ) which critically affect the enzyme activity have no effect on the degree of multiple attack . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
18,
24
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
27,
35
]
} |
it was found that anions ( chloride , bromide , and nitrate ions ) which critically affect the enzyme activity have no effect on the degree of multiple attack . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
18,
24
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
38,
45
]
} |
the purified enzyme split amide and ester linkages in l-pyroglutamyl derivatives of l-alanine , beta-naphthylamine , alpha-naphthol , and 4-methylumbelliferone , but was completely inert towards various peptides and esters used as substrates for usual amino- and carboxy-peptidases , and for endopeptidases such as tryps... | NA | {
"id": "C0030940",
"name": "peptidases",
"pos": [
271,
281
]
} | {
"id": "C0030946",
"name": "endopeptidases",
"pos": [
292,
306
]
} |
when the amino acid on the carboxyl side of aromatic amino acid residues was serine , threonine or glutamic acid , these peptide bonds , such as phe-thr , tyr-ser , and tyr-glu , were not susceptible to another serine protease from small intestine ( si-protease ) under the same experimental conditions . | NA | {
"id": "C0301713",
"name": "amino acid",
"pos": [
9,
19
]
} | {
"id": "C0031453",
"name": "phe",
"pos": [
145,
148
]
} |
when the amino acid on the carboxyl side of aromatic amino acid residues was serine , threonine or glutamic acid , these peptide bonds , such as phe-thr , tyr-ser , and tyr-glu , were not susceptible to another serine protease from small intestine ( si-protease ) under the same experimental conditions . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
211,
226
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
253,
261
]
} |
the preparation contained 10.6 % protein , its amino acid composition being characterized by high contents of glutamic acid , aspartic acid , proline , glycine , threonine , and serine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
47,
57
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
152,
159
]
} |
studies by isoelectric focusing on ampholine plate gel revealed that the solutions of the halfway reduced methemoglobin are composed of about 6 % oxyhemoglobin , 59 % intermediate hemoglobin , and 35 % methemoglobin . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
109,
119
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
202,
215
]
} |
the enzyme binds to single-stranded dna and poly [ d ( a-t ) ] copolymer , but not to the double-stranded circular dna ( form i ) of simian virus 40 . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
20,
39
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
90,
105
]
} |
kinetic analyses of the sugar phosphate : sugar transphosphorylation reaction catalyzed by the glucose enzyme ii complex of the bacterial phosphotransferase system . | NA | {
"id": "C0038655",
"name": "sugar phosphate",
"pos": [
24,
39
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
42,
47
]
} |
the sugar phosphate : sugar transphosphorylation reaction catalyzed by the glucose enzyme ii complex of the phosphotransferase system has been analyzed kinetically . | NA | {
"id": "C0038655",
"name": "sugar phosphate",
"pos": [
4,
19
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
22,
27
]
} |
the kinetic mechanism was shown to be bi-bi sequential , indicating that the enzyme ii possesses nonoverlapping binding sites for sugar and sugar phosphate . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
130,
135
]
} | {
"id": "C0038655",
"name": "sugar phosphate",
"pos": [
140,
155
]
} |
in vitro kinetic studies of the transphosphorylation reaction catalyzed by the mutant enzyme showed a decrease in maximal velocity and increases in the km values for both the sugar and sugar phosphate substrates . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
175,
180
]
} | {
"id": "C0038655",
"name": "sugar",
"pos": [
185,
190
]
} |
binding was inhibited by n-acetylglucosamine or by glycosides of this sugar , the most effective inhibitor being orosomucoid ( alpha1-acid glycoprotein ) pretreated with sialidase and beta-galactosidase . | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
51,
61
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
70,
75
]
} |
from the similarity in the fragments formed by digestion with s. aureus protease , it appears that this radioactive protein is probably a precursor of a 32,000-dalton protein which is a component of the thylakoid . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
116,
123
]
} | {
"id": "C0033665",
"name": "precursor",
"pos": [
138,
147
]
} |
that the imp-free membrane blisters in embryonic corneas are artefacts of fixation is demonstrated by ( a ) their absence in replicas of fibroblasts frozen and fractured without prior aldehyde fixation and ( b ) their absence in sections of fibroblasts fixed in a combination of glutaraldehyde and osmium tetroxide . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
184,
192
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
279,
293
]
} |
the distributions of acetylcholinesterase ( ache ) and butyrylcholinesterase ( buche ) in the superior cervical ganglion ( scg ) of the cat were determined by electron microscopy ( em ) with the bis- ( thioacetoxy ) aurate ( i ) , or au ( ta ) 2 , method . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
21,
41
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
55,
76
]
} |
physostigmine-treated controls , for inhibition of ache or buche , were stained concomitantly with tissue for enzyme localization by the au ( ta ) 2 method for em examination in each experiment . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
51,
55
]
} | {
"id": "C0008429",
"name": "buche",
"pos": [
59,
64
]
} |
it is proposed that a trophic factor released by the preganglionic terminals is probably required for the synthesis of postsynaptic neuronal ache , and that buche may serve as a precursor of ache at that site . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
157,
162
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
191,
195
]
} |
combining this technique with procedures which render the interior of the microsomal vesicles accessible to lectins and remove luminal proteins , it was found that rm membranes contain binding sites for con a and for lens culinaris agglutinin ( lca ) located exclusively on the cisternal face of the membrane . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
108,
115
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
135,
143
]
} |
these observations demonstrate that : ( a ) sugar moieties of microsomal glycoproteins are exposed only on the luminal surface of the membranes and ( b ) microsomal membrane glycoproteins have incomplete carbohydrate chains without the characteristic terminal trisaccharides n-acetylglucosamine comes from galactose come... | NA | {
"id": "C0025248",
"name": "membrane glycoproteins",
"pos": [
165,
187
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
365,
378
]
} |
the formation of large aggregates by ionic interactions between acidic glucosaminoglycans and cationic secretory proteins has been proposed as one of the critical steps in the concentration process in the condensing vacuoles of secretory cells . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
37,
42
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
94,
102
]
} |
these studies show : ( a ) tubulin is present in sj and psd fractions and is identical to cytoplasmic tubulin , ( b ) actin in these fractions is very similar to the gamma- and beta-actin found predominantly in nonmuscle cells , and ( c ) the major psd protein is distinct from all other known fibrous proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
253,
260
]
} | {
"id": "C0036425",
"name": "fibrous",
"pos": [
294,
301
]
} |
pl fusion was strongly inhibited by low concentrations of kf ( 50 % inhibition at 2.7 mm ) , and by approximately tenfold higher concentrations of kcl , while kcn and 2,4-dinitrophenol ( 2,4-dnp ) had little effect . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
171,
184
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
191,
194
]
} |
we also domonstrate how the procedure can detect minor antibody species in an antiserum directed against a cell membrane . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
55,
63
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
78,
87
]
} |
to examine the possibility that the unresponsiveness to insulin of the melanoma cells is attributable to a lack of insulin receptors , we have measured the binding of 125i-labeled insulin to the fibroblasts , melanoma cells , and fibroblast x melanoma hybrids . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
11,
14
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
230,
240
]
} |
this suggests that the class of insulin receptors characterized by this effect is absent on the pg19 cells , and present on the fibroblasts and fibroblast x pg19 hybrids . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
144,
154
]
} |
a gas chromatographic -- high-resolution mass fragmentographic method for the simultaneous determination of adrenaline and noradrenaline from human plasma is presented . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
108,
118
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} |
rapid quantitative method for the simultaneous determination of carbamazepine , carbamazepine-10,11-epoxide , diphenylhydantoin , mephenytoin , phenobarbital and primidone in serum by thin-layer chromatography . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
144,
157
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
162,
171
]
} |
stable derivatives for the gas chromatographic determination of synthetic anabolic stilbene residues ( diethylstilbestrol , dienestrol and hexestrol ) in meat and organs of treated cattle in the sub-parts per billion ( 10 ( 9 ) ) level . | NA | {
"id": "C0038333",
"name": "stilbene",
"pos": [
83,
91
]
} | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
103,
121
]
} |
stable derivatives for the gas chromatographic determination of synthetic anabolic stilbene residues ( diethylstilbestrol , dienestrol and hexestrol ) in meat and organs of treated cattle in the sub-parts per billion ( 10 ( 9 ) ) level . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
103,
121
]
} | {
"id": "C0019467",
"name": "hexestrol",
"pos": [
139,
148
]
} |
a method for the determination of diethylstilbestrol and the related compounds dienestrol and hexestrol residues in meat and organs of treated cattle is described . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
34,
52
]
} | {
"id": "C0019467",
"name": "hexestrol",
"pos": [
94,
103
]
} |
a rapid gas-liquid chromatographic method has been developed for the analysis of phenobarbitone , primidone and phenytoin in small ( 50 microliter ) volumes of either blood plasma or serum . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
81,
95
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
98,
107
]
} |
analysis of antibody assay methods and classes of viral antibodies in serodiagnosis of cytomegalovirus infection . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
12,
20
]
} | {
"id": "C0003253",
"name": "viral antibodies",
"pos": [
50,
66
]
} |
separation of immunoglobulin classes of 20 serum pairs by sucrose gradient centrifugation indicated that these antibodies with iha were of the immunoglobulin m ( igm ) class and those with cf-ge were of the igg class . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
14,
36
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} |
separation of immunoglobulin classes of 20 serum pairs by sucrose gradient centrifugation indicated that these antibodies with iha were of the immunoglobulin m ( igm ) class and those with cf-ge were of the igg class . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
14,
36
]
} | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
143,
159
]
} |
by separation of immunoglobulin classes , rises in igg cmv antibody titers were seen with iha , rises not observed in the whole serum because of high igm antibody titers in the first serum specimen . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
17,
39
]
} | {
"id": "C0020861",
"name": "igm",
"pos": [
150,
153
]
} |
a third antibody , goat anti-rabbit igg , was incorporated into the system to separate immune complexes formed between iodinated ha , nasal wash test specimen , and second antibody . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
87,
103
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
172,
180
]
} |
the results indicate that the net glucose release by the kidney in vivo in normal fed rats was 0.75+/-0.13 mg/dl per min , and that its contribution to blood glucose was 25.9+/-5.0 % . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
34,
41
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
152,
165
]
} |
the types of iri components observed in plasma are evidence in support of a physiologic role of trypsin-and carboxypeptidase b-like enzymes in the conversion of proinsulin to insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
161,
171
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
175,
182
]
} |
overnight preincubation of peripheral blood mononuclear cells results in an increased response of the cells to phytohemagglutinin or concanavalin a compared to the response of fresh cells . | NA | {
"id": "C1321301",
"name": "peripheral",
"pos": [
27,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
182,
187
]
} |
to characterize the cell ( s ) responsible for the suppressor-cell dysfunction in active systemic lupus erythematosus ( sle ) , we fractionated blood mononuclear cells into thymus-derived ( t ) , bone marrow-derived ( b ) , and monocyte-depleted populations . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
20,
24
]
} | {
"id": "C1321301",
"name": "blood mononuclear",
"pos": [
144,
161
]
} |
concanavalin a-activated autologous or allogeneic active sle cells and nonactivated cells from active or inactive sle failed to suppress the various b-cell functions . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
39,
49
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
84,
89
]
} |
in order to develop a rapid and simple method based on chemical alterations in gingival pockets during inflammation , the hemastix strips were used to record the degree of gingivitis . | NA | {
"id": "C0017571",
"name": "gingival pockets",
"pos": [
79,
95
]
} | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
172,
182
]
} |
according to the present results the strip index can be used for the assessment of biochemical changes in gingival pockets resulting from the development of gingivitis . | NA | {
"id": "C0017571",
"name": "gingival pockets",
"pos": [
106,
122
]
} | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
157,
167
]
} |
the distribution of immunoreactive enkephalin in rat brain and spinal cord was studied by immunoperoxidase staining using antiserum to leucine-enkephalin ( [ leu5 ] -enkephalin ) or methionine-enkephalin ( [ met5 ] -enkephalin ) . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
35,
45
]
} | {
"id": "C0014294",
"name": "leucine-enkephalin",
"pos": [
135,
153
]
} |
the distribution of immunoreactive enkephalin in rat brain and spinal cord was studied by immunoperoxidase staining using antiserum to leucine-enkephalin ( [ leu5 ] -enkephalin ) or methionine-enkephalin ( [ met5 ] -enkephalin ) . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
35,
45
]
} | {
"id": "C0014295",
"name": "methionine-enkephalin",
"pos": [
182,
203
]
} |
the results of the histochemical staining show that certain structures which positively stain for enkephalin closely correspond to the distribution of opiate receptors in the brain and thus support the concept that the endogenous opiate peptides are involved in the perception of pain and analgesia . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
98,
108
]
} | {
"id": "C0205753",
"name": "endogenous opiate peptides",
"pos": [
219,
245
]
} |
increase in the caliber and course tortuosity of the optic nerve ( on ) can be demonstrated by computed tomography ( ct ) in cases of papilledema due to intracranial tumors , hydrocephalus , pseudotumor cerebri , and other conditions causing increased intracranial pressure . | NA | {
"id": "C0033845",
"name": "pseudotumor cerebri",
"pos": [
191,
210
]
} | {
"id": "C0151740",
"name": "increased intracranial pressure",
"pos": [
242,
273
]
} |
this hemolytic consumption was via the alternative pathway as defined by ethylenediaminetertraacetic acid/ethylene-glycol-bis- ( beta-amino-ethyl ether ) n , n'-tetraacetic acid ( edta/egta ) differential serum chelation , factor b conversion , and complement reductions in serum from guinea pigs deficient in c4 . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
223,
231
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
249,
259
]
} |
by using a sensitive radioimmunoassay technique , the absorbed antisera were shown to contain an antibody population that was specific for the hybrid hemoglobin and did not cross-react with normal hemoglobins . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
63,
71
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
97,
105
]
} |
however , with the absorbed lepore-specific antisera , the three known types of lepore hemoglobins were antigenically indistinguishable from each other , suggesting that antibodies are not produced to the primary structural differences which define the three non-alpha-chains of the lepore hemoglobins . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
44,
52
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
170,
180
]
} |
analysis is possible , however , by use of radio-iodinated bovine serum albumin as antigen at low concentrations ( less than 200 ng/ml ) and optimal concentration of antibody to avoid precipitation of antigen -- antibody complexes with human erythrocytes without participation of complement . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
166,
174
]
} | {
"id": "C0003313",
"name": "antigen",
"pos": [
201,
208
]
} |
the second strain of k. pneumoniae ( ro106 ) produced gentamicin adenyltransferase and maintained aminoglycoside resistance only when propagated in antibiotic-containing medium . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
54,
64
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
98,
112
]
} |
microbicidal activity was induced by incubation of macrophages with syngeneic spleen lymphocytes , which were stimulated either by allogeneic cells in mixed lymphocyte culture ( mlc ) or by the plant lectin concanavalin a ( con a ) . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
194,
206
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
207,
221
]
} |
the parents of these hybrids were a/hej or mus poschiavinus peritoneal exudate cells or balb/c primary embryo fibroblasts and e36 , a chinese hamster lung fibroblast deficient in hypoxanthine guanine phosphoribosyltransferase . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
79,
84
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
155,
165
]
} |
evidence for differentiation signals delivered by lipid a and by a protein rich fraction of lipopolysaccharides . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
50,
57
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
92,
111
]
} |
in protein-free lps , lipid a bears the stimulatory signal which results in the differentiation of elicited macrophages into killer cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
16,
19
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
22,
29
]
} |
extraction of lps by the butanol or boivin procedures produces preparations in which lps is complexed through its lipid a moiety to a protein rich component , lap . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
14,
17
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
114,
121
]
} |
this may reflect the fibroblastic origin of decidual cells or be a marker expressed on some decidual cells possibly under hormonal control . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
17,
20
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
21,
33
]
} |
suppressor cells were enriched in the adherent population by a factor of at least 25 , establishing that functional , epitope-specific , idiotype-bearing t cells can be significantly purified by this procedure . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
118,
125
]
} | {
"id": "C0021013",
"name": "idiotype",
"pos": [
137,
145
]
} |
these findings are interpreted to mean that not only do the cations affect ouabain binding at the external loading sites on the pump from which ions are translocated inward , but that there are additional sites on the external aspect of the pump at which cations can promote ouabain binding , and that these sites can be... | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
63,
67
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
255,
262
]
} |
cytochalasin d did not suppress formation of interferon by fibroblasts ( l cells ) or spleen cells stimulated with either hvj or ndv . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
93,
98
]
} |
in contrast , during the same period and under the same conditions the titres of cell-free vzv were 10 ( 2 ) to 10 ( 3 ) times lower when grown on human foreskin fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
21,
24
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
162,
173
]
} |
detection of the epstein-barr ( ebv ) antigens , early antigen ( ea ) , viral capsid antigen ( vca ) , and nuclear antigen ( ebna ) by the indirect immunoperoxidase technique was highly sensitive . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
38,
45
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
72,
77
]
} |
detection of the epstein-barr ( ebv ) antigens , early antigen ( ea ) , viral capsid antigen ( vca ) , and nuclear antigen ( ebna ) by the indirect immunoperoxidase technique was highly sensitive . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
38,
45
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
107,
122
]
} |
antibody titers to ebna , ea , and vca were determined in more than 25 sera of patients with burkitt lymphoma ( bl ) , nasopharyngeal carcinoma ( npc ) , or normal persons . | NA | {
"id": "C0003320",
"name": "ea",
"pos": [
26,
28
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
35,
38
]
} |
urinary catecholamines and metabolites and urinary amphetamine excretion were examined for hyperactive and normal boys following a single dose of dextroamphetamine ( 0.5 mg/kg ) and placebo . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
51,
62
]
} | {
"id": "C0011812",
"name": "dextroamphetamine",
"pos": [
146,
163
]
} |
a positive correlation existed between the net increase of pyridoxal phosphate 60 minutes following pyridoxine loading and the net increase of blood xylose 60 minutes after oral loading . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
59,
78
]
} | {
"id": "C0034272",
"name": "loading",
"pos": [
178,
185
]
} |
the fatty acid composition of total lipids , triglycerides ( tg ) , free fatty acids ( ffa ) , phosphatidyl choline ( pc ) , and phosphatidyl ethanola-mine ( pe ) fractions was determined . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
68,
84
]
} |
during the fifth week of protein restriction enzyme activities , putrescine and spermidine concentrations and orotic acid incorporation returned to control levels . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
65,
75
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
91,
105
]
} |
the lipolytic activity had a ph optimum of 5.4 and produced partial glycerides ( mono and diglycerides ) , glycerol , and free fatty acids . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
68,
78
]
} | {
"id": "C0012262",
"name": "diglycerides",
"pos": [
90,
102
]
} |
there were no significance differences between control subjects and gastrectomized patients in the apparent lag time prior to the start of absorption ( 23.6 vs. 22.8 min ) , peak serum tetracycline concentration ( 1.72 vs. 1.75 microgram/ml ) , the time of attainment of peak concentrations ( 3.35 vs. 3.42 hr ) , the ap... | NA | {
"id": "C0000854",
"name": "absorption",
"pos": [
139,
149
]
} | {
"id": "C1373172",
"name": "absorption half-life",
"pos": [
339,
359
]
} |
a sensitive fluorescence -- tlc densitometric procedure was developed for the specific determination of diazepam ( i ) and its two metabolites , desmethyldiazepam ( ii ) and oxazepam ( iii ) , in serum . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
104,
112
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
145,
162
]
} |
the solubilizations of ethinyl estradiol and the two c21 steroids , progesterone and 21-hydroxyprogesterone , were dependent on each other so that a varying amount of the steroid solubilized first was precipitated by an excess of the second steroid . | NA | {
"id": "C0033006",
"name": "c21 steroids",
"pos": [
53,
65
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
241,
248
]
} |
antiserum was developed in rabbits , and a second antibody was used to separate bound from free danazol . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
50,
58
]
} |
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