text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
simultaneous determination of niacin , niacinamide , pyridoxine , thiamine , and riboflavin in multivitamin blends by ion-pair high-pressure liquid chromatography . | NA | {
"id": "C0027996",
"name": "niacin",
"pos": [
30,
36
]
} | {
"id": "C0028027",
"name": "niacinamide",
"pos": [
39,
50
]
} |
a high-pressure liquid chromatographic procedure for the simultaneous determination of niacin , niacinamide , pyridoxine , thiamine , and riboflavin was developed and applied to the analysis of multivitamin blends for these water-soluble vitamins . | NA | {
"id": "C0027996",
"name": "niacin",
"pos": [
87,
93
]
} | {
"id": "C0028027",
"name": "niacinamide",
"pos": [
96,
107
]
} |
integration of this signal relative to a signal from cephradine provides the data necessary to determine the percentage of cephalexin present . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
53,
63
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
123,
133
]
} |
in terms of total analgesic effect , oxycodone was 10 times as potent as codeine , while in terms of peak analgesia it was 12 times as potent . | NA | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
37,
46
]
} | {
"id": "C0009214",
"name": "codeine",
"pos": [
73,
80
]
} |
these relative potency relationships of oxycodone , taken in conjunction with the oral/parenteral potency ratios of codeine and oxycodone established in the previous paper and several previous relative potency assays involving morphine , oxymorphone and codeine , demonstrate a highly consistent pattern of analgesic str... | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
116,
123
]
} | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
400,
409
]
} |
2,6-dichlorophenyl-guanidine , a known metabolite of clonidine , did not cross-react with the antiserum whereas another metabolite , 4-hydroxyclonidine , was as potent as clonidine in displacing labeled clonidine from the antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
94,
103
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
222,
230
]
} |
these responses were markedly reduced by pge1 and pge2 and significantly augmented by indomethacin and aspirin , suggesting the occurrence of the pge-mediated negative feedback . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
50,
54
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
146,
149
]
} |
we hypothesize that the high oral/parenteral relative potency ratios of codeine and oxycodone relative to morphine and its congeners are not due to more efficient absorption after oral administration , but rather that methylation at position 3 in codeine and oxycodone protects these drugs from rapid first-pass metaboli... | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
72,
79
]
} | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
259,
268
]
} |
it is concluded that endogenous prostaglandins do not obscure or alter the vascular and saluretic actions of intrarenal prostaglandin e ( 1 ) . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
32,
46
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
120,
135
]
} |
at 20 degrees c ambient temperature the change in body temperature after the endotoxin is still biphasic , but the transient fall is more pronounced and , finally , hypothermia develops . | NA | {
"id": "C0005904",
"name": "change",
"pos": [
40,
46
]
} | {
"id": "C0020672",
"name": "hypothermia",
"pos": [
165,
176
]
} |
finally , our data suggest that ( i ) cl exit from the cell across the basolateral membrane may be coupled to the co-transport of a cation or the countertransport of an anion ; | NA | {
"id": "C0021966",
"name": "i",
"pos": [
1,
2
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
169,
174
]
} |
glutamine entry at 0.06 mm was inhibited by a variety of amino acids at 3 mm , including dibasic amino acids , glycine , valine , and phenylalanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
57,
68
]
} | {
"id": "C0002523",
"name": "dibasic",
"pos": [
89,
96
]
} |
glutamine entry at 0.06 mm was inhibited by a variety of amino acids at 3 mm , including dibasic amino acids , glycine , valine , and phenylalanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
57,
68
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
111,
118
]
} |
glutamic acid entry at 0.06 mm was inhibited 20 -- 30 % by 3 mm phenylalanine , valine , alpha-aminoisobutyric acid , and glutamine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
0,
13
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
122,
131
]
} |
no metabolic alteration of glutamic acid was observed on incubation with membrane vesicles , but glutamine was significantly hydrolyzed to glutamic acid upon prolonged incubation . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
97,
106
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
139,
152
]
} |
cytogenetic diagnosis of cancer : abnormalities of chromosomes and polyploid levels in the bone marrow of patients with small cell anaplastic carcinoma of the lung . | NA | {
"id": "C0008626",
"name": "abnormalities of chromosomes",
"pos": [
34,
62
]
} | {
"id": "C0032578",
"name": "polyploid",
"pos": [
67,
76
]
} |
muscle of gibbons infected postnatally had little or no proviral dna , whereas gibbons infected prenatally had a large quantity of proviral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
65,
68
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
142,
143
]
} |
simultaneous differential staining of phosphoproteins , sialoglycoproteins , hyaluronic acid , sulfated glycosaminoglycans , proteins , and nucleic acids in human breast tissue with a cationic carbocyanine dye . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
38,
53
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
125,
133
]
} |
detailed analysis of multiple clotting factor changes following critical surgical illness ( factors i , ii , v , viii , ix , x , xi , and platelets , fibrin degradation products and plasminogen ) were carried out prospectively in 48 patients . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
30,
45
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
120,
122
]
} |
the method can be used for survival following any sort of trauma , here illustrated for survival of burned patients . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
58,
64
]
} | {
"id": "C0006434",
"name": "burned",
"pos": [
100,
106
]
} |
as judged from its cleavage pattern and its response to proteolytic inhibitors , the proteolytic activity appears papain-like , and the protease responsible for it may be classified as a thiol protease . | NA | {
"id": "C0030346",
"name": "papain",
"pos": [
114,
120
]
} | {
"id": "C0010661",
"name": "thiol protease",
"pos": [
187,
201
]
} |
tryptic peptide analyses indicated that the e14k protein is unrelated to the dna binding proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
49,
56
]
} | {
"id": "C0012940",
"name": "dna binding proteins",
"pos": [
77,
97
]
} |
examination of levels of each cellular dna polymerase in these preparations from each step of both purification procedures revealed that dna polymerase beta had a greater tendency to copurify with bovine parvovirus and kilham rat virus than did dna polymerases alpha or gamma . | NA | {
"id": "C0012892",
"name": "dna polymerase",
"pos": [
39,
53
]
} | {
"id": "C0525039",
"name": "dna polymerase beta",
"pos": [
137,
156
]
} |
our data suggest that the loss of infectivity observed among di viruses may be due to nonspecific loss of a viral rna segment ( s ) , and the interfering property of di viruses may be due to interfering rna segments ( dirna , d1 to d6 ) . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
108,
117
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
220,
223
]
} |
instead , the results were consistent with the hypothesis that transfection of chicken embryo fibroblasts by rous sarcoma virus dna proceeded by transcription of donor dna , formation of extracellular progeny virus , and secondary virus infection of sensitive cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
260,
265
]
} |
consequently , replicating chromosomes failed to extensively continue nascent dna chain growth , and the conversion of viral replicating dna into mature dna was seven to eight times less than that observed in nuclear extracts . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
119,
124
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
153,
156
]
} |
second , diluting either nuclear extracts or replicating chromosomes before incubation in vitro stimulated total dna synthesis but was accompanied by the simultaneous appearance of small-molecular-weight nascent dna not associated with intact viral dna templates and a decrease in the synthesis of covalently closed vira... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
113,
116
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
316,
325
]
} |
microscopic examination of the urinary sediment to determine the degree of pyuria is an accepted method to screen for urinary tract infection . | NA | {
"id": "C0034359",
"name": "pyuria",
"pos": [
75,
81
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
118,
141
]
} |
eighty-nine men with gonococcal urethritis were randomly treated with trimethoprim-sulfamethoxazole , four tablets ( trimethoprin , 320 mg , and sulfamethoxazole , 1,600 mg ) twice daily for two days , or ampicillin , 3.5 g , plus probenecid , 1 g , in a single dose . | NA | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
70,
99
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
145,
161
]
} |
if normal contraction occurs after cholecystokinin ( or sincalide ) , an unusually large gallbladder is of no importance . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
35,
50
]
} | {
"id": "C0037167",
"name": "sincalide",
"pos": [
56,
65
]
} |
chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of plasmodium falciparum . | NA | {
"id": "C1383389",
"name": "chloroquine hydrochloride",
"pos": [
0,
25
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
148,
159
]
} |
chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of plasmodium falciparum . | NA | {
"id": "C1383389",
"name": "chloroquine hydrochloride",
"pos": [
0,
25
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
148,
159
]
} |
to investigate the role of renal prostaglandin in the regulation of sodium metabolism , ruinary prostaglandin e excretion , an indicator of renal prostaglandin synthesis , urinary sodium excretion , plasma renin activity and urinary aldosterone excretion were measured in 84 normal subjects and 55 patients with essentia... | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
33,
46
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
96,
111
]
} |
furthermore , the role of endogenous increases of acth , deoxycorticosterone , and 18 alpha-hydroxy-deoxycorticosterone upon blood pressure was studied in rats by administerating metopirone . | NA | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
57,
76
]
} | {
"id": "C0000173",
"name": "18",
"pos": [
83,
85
]
} |
in vitro studies of the effects of various organic mercury compounds and heavy metals on rat-liver mitochondria . | NA | {
"id": "C0025424",
"name": "mercury",
"pos": [
51,
58
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
73,
85
]
} |
tolerance and cross tolerance to toxic effects of morphine , methadone and 1-alpha-acetylmethadol ( laam ) in naive and morphine dependent rats . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
61,
70
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
83,
97
]
} |
the major glycosaminoglycan in both control and atherosclerotic aortas was chondroitin sulfate with lesser amounts of heparan sulfate , dermatan sulfate , and hyaluronic acid . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
10,
27
]
} | {
"id": "C0019143",
"name": "sulfate",
"pos": [
145,
152
]
} |
epinephrine , norepinephrine and dopamine levels were measured in plasma collected from the left adrenolumbar vein ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
14,
28
]
} |
the catecholamine effects were concentration-dependent within the range 1-100 microm , and the order of the potency was isoprenaline greater than adrenaline greater than noradrenaline greater than dopamine = phenylephrine . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
4,
17
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
120,
132
]
} |
the catecholamine effects were concentration-dependent within the range 1-100 microm , and the order of the potency was isoprenaline greater than adrenaline greater than noradrenaline greater than dopamine = phenylephrine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
146,
156
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
170,
183
]
} |
ct caused a statistically significant drop in urine calcium , phosphorus and hydroxyproline ( oh-proline ) excretion in fh patients and a concomitant increase in serum pth levels . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
77,
91
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
97,
104
]
} |
on the delta 5-pathway : dehydroepiandrosterone was extremely low while 17 alpha-hydroxypregnenolone and pregnenolone were almost normal ; | NA | {
"id": "C0376260",
"name": "17",
"pos": [
72,
74
]
} | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
105,
117
]
} |
acth stimulation induced a subnormal rise of cortisol and 11 beta-hydroxyandrostenedione , a low or absent rise of dehydroepiandrosterone , 17 alpha-hydroxypregnenolone , androstenedione and 17 alpha-hydroxyprogesterone contrasting with a marked rise of pregnenolone and progesterone . | NA | {
"id": "C0376260",
"name": "17",
"pos": [
140,
142
]
} | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
254,
266
]
} |
dexamethasone induced only a minute decrease in the delta 4-progestagens , a marked decrease in pregnenolone , with a more than 80 % reduction of 17 alpha- hydroxypregnenolone , dehydroepiandrosterone , dehydroepiandrosterone sulfate and androstenedione . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
96,
108
]
} | {
"id": "C0376260",
"name": "17 alpha",
"pos": [
146,
154
]
} |
the purpose of this study was to correlate ultrastructural features of tendon collagen fibrils at various stages of development with the presence of procollagen , pn-collagen , pc-collagen , and the free amino propeptides and carboxyl propeptide of type i procollagen . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
149,
160
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
259,
267
]
} |
procollagen and the intermediates pn-collagen and pc-collagen are present in tendons up to 18 days . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
0,
11
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
53,
61
]
} |
brattleboro rats without diabetes insipidus were subjected to sodium chloride enrichment ( 20-fold increase in dietary salt ) at various stages of their development . | NA | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
62,
77
]
} | {
"id": "C0206136",
"name": "dietary salt",
"pos": [
111,
123
]
} |
145-2c11 was not mitogenic for lpr dn lymph node cells ( lnc ) , even in the presence of the phorbol ester 12-o-tetradecanoylphorbol 13-acetate , whereas mrl/mp-+/+ ( +/+ ) lnc responded strongly . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
93,
100
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
107,
143
]
} |
this was not due solely to a property of the 145-2c11 antibody , because both tpa and the f23.1 anti-tcr mab also provoked a faster modulation of the tcr in lpr dn lnc . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
54,
62
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
105,
108
]
} |
mouse ltk- cells expressing human fc gamma rii or a mutant of fc gamma rii lacking the entire cytoplasmic domain of the receptor mediate anti-cd3-induced lymphoproliferation in cultures of adherent cell-depleted human pbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
11,
16
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
218,
222
]
} |
normal thy-1+ ec express abundant levels of functional rna for tcr-gamma and delta-chains and for the cd3 delta-chain , whereas nude thy-1+ ec produce no detectable tcr-delta and no cd3 delta-rna and only truncated , presumably germ-line tcr-gamma transcripts , as suggested by lack of hybridization with gamma-v region ... | NA | {
"id": "C0887909",
"name": "functional rna",
"pos": [
44,
58
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
192,
195
]
} |
the glycoprotein digested with n-glycanase , neuraminidase , or o-glycanase could still be immunoprecipitated with the 44g4 mab indicating that the antigenic epitope resides in the polypeptide . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
148,
157
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
158,
165
]
} |
since autoantigen specific t cells may play an important role in initiating autoimmune diseases , tcr were analyzed in different autoimmune diseases and control groups including rheumatoid arthritis , graves disease , idiopathic thrombocytopenic purpura , psoriasis , sle , insulin-dependent diabetes mellitus , and in n... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
76,
95
]
} | {
"id": "C0018213",
"name": "graves disease",
"pos": [
201,
215
]
} |
since autoantigen specific t cells may play an important role in initiating autoimmune diseases , tcr were analyzed in different autoimmune diseases and control groups including rheumatoid arthritis , graves disease , idiopathic thrombocytopenic purpura , psoriasis , sle , insulin-dependent diabetes mellitus , and in n... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
76,
95
]
} | {
"id": "C0398650",
"name": "idiopathic thrombocytopenic purpura",
"pos": [
218,
253
]
} |
since autoantigen specific t cells may play an important role in initiating autoimmune diseases , tcr were analyzed in different autoimmune diseases and control groups including rheumatoid arthritis , graves disease , idiopathic thrombocytopenic purpura , psoriasis , sle , insulin-dependent diabetes mellitus , and in n... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
76,
95
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
268,
271
]
} |
since autoantigen specific t cells may play an important role in initiating autoimmune diseases , tcr were analyzed in different autoimmune diseases and control groups including rheumatoid arthritis , graves disease , idiopathic thrombocytopenic purpura , psoriasis , sle , insulin-dependent diabetes mellitus , and in n... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
76,
95
]
} | {
"id": "C0011854",
"name": "insulin-dependent diabetes mellitus",
"pos": [
274,
309
]
} |
under endotoxin-free conditions , unstimulated human pbmc do not release tnf-alpha , as measured in a sensitive assay with 51cr release in 6 h from actinomycin d-treated wehi 164 cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
53,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
179,
184
]
} |
because the peyer 's patches ( pp ) , compared with spleen and lymph nodes , are enriched for precursors of iga-secreting cells , we tested whether il-4 and il-5 would have a more profound effect on iga secretion by polyclonally stimulated pp cells than spleen cells . | NA | {
"id": "C0018956",
"name": "precursors",
"pos": [
94,
104
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
261,
266
]
} |
since a second fcr with mr = 40 kda recognized by mab iv-3 , recently has been identified on pmn , we sought to determine if this fcr was resistant to elastase and thus accounted for the elastase stability of igg-mediated pmn functions . | NA | {
"id": "C0030306",
"name": "elastase",
"pos": [
151,
159
]
} | {
"id": "C0064833",
"name": "elastase",
"pos": [
187,
195
]
} |
we report that large quantities of a purified anti-il-4 mab inhibit primary in vivo polyclonal ige responses by 99 % in mice infected with nippostrongylus brasiliensis or injected with anti-igd antibodies , and totally inhibit secondary ag-specific ige responses to tnp-keyhole limpet hemocyanin without effect on either... | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
56,
59
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
194,
204
]
} |
incubation of macrophages with ifn-gamma for 48 h in the presence of lps inhibited h2o2 production but augmented no2- release , whereas incubation in the presence of the arginine analog ng-monomethylarginine inhibited no2- release but not h2o2 production . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
170,
178
]
} | {
"id": "C0069477",
"name": "ng-monomethylarginine",
"pos": [
186,
207
]
} |
experiments to investigate the fate of intravascularly administered leukotriene ( lt ) a4 , an unstable intermediate of lt generation , were performed in isolated , ventilated , and blood-free perfused rabbit lungs . | NA | {
"id": "C0125631",
"name": "leukotriene",
"pos": [
68,
79
]
} | {
"id": "C0023545",
"name": "lt",
"pos": [
120,
122
]
} |
experiments with application of tritiated lta4 showed exclusive origin of the detected lt from the exogenously applied precursor . | NA | {
"id": "C0125631",
"name": "lta4",
"pos": [
42,
46
]
} | {
"id": "C0023545",
"name": "lt",
"pos": [
87,
89
]
} |
in the dose range of lta4 used , the enzymatic conversion of this lt precursor did not approach saturation . | NA | {
"id": "C0125631",
"name": "lta4",
"pos": [
21,
25
]
} | {
"id": "C0023545",
"name": "lt",
"pos": [
66,
68
]
} |
in the presence of phorbol ester tetradecanoyl phorbol acetate , there is a modest increase in the rate of internalization . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
19,
32
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
47,
54
]
} |
the addition of il-1 or the phorbol ester 12-o-tetradecanoylphorbol-13-acetate in combination with con a also restored both [ 3h ] tdr incorporation and il-2 synthesis in macrophage-depleted cultures . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
28,
41
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
42,
78
]
} |
the data indicate that the species of il-1 associated with murine macrophage membranes shares at least two epitopes with il-1 alpha and probably represents a product of the il-1 alpha gene . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
38,
42
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
173,
183
]
} |
picryl chloride factor ( pc1-f ) is an antigen ( tnp hapten ) -binding t cell factor that initiates pc1 contact sensitivity ( cs ) . | NA | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
0,
15
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
53,
59
]
} |
equivalent picogram amounts of pge were measured in cm derived from bm or spl cells from either control or pge2-treated mice , indicating a low probability that injected pge2 was carried over in the cm and contributed to cfu-gm inhibition . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
31,
34
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
170,
174
]
} |
a lambda gt11 library of mycobacterium leprae dna was screened with m. leprae-reactive human t cell clones as probes , allowing the isolation of a m. leprae dna clone encoding the unidentified ag . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
157,
160
]
} |
because epitopes c1 and c2 can be formed by the same antigenic peptide , but epitope c1 is not present on sv40 transformed kkml cells , epitopes c1 and c2 must differ in the contribution made by residue 152 of the mhc class i molecule . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
53,
62
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
136,
144
]
} |
these data show that ctl epitopes on transformed cells can be made up of ag fragments , and strengthen the idea that this is a general phenomenon for both class i and class ii restricted t cell epitopes . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
25,
33
]
} | {
"id": "C0282580",
"name": "t cell",
"pos": [
187,
193
]
} |
these data suggest that the human mab reactive with group a streptococci and myosin reflect the antibodies seen in sera from infected patients or acute rheumatics and that the b lymphocyte clones capable of producing these cross-reactive antibodies are also present in normal individuals . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
34,
37
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
238,
248
]
} |
although the number of class i alleles we examined is still limited , these results indicate that antigenic fragments derived from the processed h-43a and h-43b alloantigens possess an indistinguishable epitope ( agretope ) , and that such agretope either interacts only with the privileged kb molecules or allows to bes... | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
98,
107
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
203,
210
]
} |
we asked whether induction of specific immune tolerance to the major cns myelin proteins , myelin basic protein ( mbp ) and proteolipid protein ( plp ) , could inhibit the development of r-eae . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
73,
88
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
91,
111
]
} |
by using ct as a hapten , we had previously identified a mab ( ct07 ) with restricted specificity to mature ct , and had shown that another mab ( ct08 ) directed to a different epitope bound to both ct and the ct precursor . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
17,
23
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
177,
184
]
} |
in this study , we used synthetic peptides analogous to various regions of biosynthetic intermediates of ct as haptens , and generated a library of mab which define distinct epitopes . | NA | {
"id": "C0018593",
"name": "haptens",
"pos": [
111,
118
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
174,
182
]
} |
pretreatment of neutrophils with 800 micrograms/ml of soluble yeast beta-glucan inhibited their ingestion of zymosan by 84 % ( mean +/- sd , n = 3 ) , with 50 % inhibition occurring with 100 micrograms/ml of soluble beta-glucan ; | NA | {
"id": "C0043552",
"name": "zymosan",
"pos": [
109,
116
]
} | {
"id": "C1134651",
"name": "beta-glucan",
"pos": [
216,
227
]
} |
the fine specificity and relative affinity of these mab for lipid a and lps were also determined . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
60,
67
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
72,
75
]
} |
these changes were specific in that rna levels of another nuclear proto-oncogene , c-myc , were increased by il-2 but not by ifn-beta , whereas hla class i rna levels were relatively unchanged by either il-2 or ifn-beta treatment . | NA | {
"id": "C0035700",
"name": "rna",
"pos": [
36,
39
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
156,
159
]
} |
the three immunoassays were shown to be specific for the major protein contaminants in either monoclonal antibodies or the recombinant proteins and were necessary in demonstrating their purity . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
63,
70
]
} | {
"id": "C0034861",
"name": "recombinant proteins",
"pos": [
123,
143
]
} |
briefly , the specific target antigen on the cells is bound by the monoclonal antibodies and revealed by use of a fluoresceinated second antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
67,
88
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
137,
145
]
} |
patients with rheumatoid arthritis ( ra ) , sjogrens syndrome ( ss ) and undifferentiated connective tissue disease ( uctd ) had low levels of anti-p67 with a prevalence 11.6 % and 18 % , respectively , whilst patients with systemic lupus erythematosus ( sle ) and mixed connective tissue disease ( mctd ) had high level... | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
14,
34
]
} | {
"id": "C1527336",
"name": "sjogrens syndrome",
"pos": [
44,
61
]
} |
anti-b or anti-d antibodies were detected at high levels in sle ( prevalence 30 % ) but were found rarely in uctd and mctd ( prevalence 7 % and 10 % ) and not at all in ra or ss sera . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
99,
101
]
} | {
"id": "C1527336",
"name": "ss",
"pos": [
175,
177
]
} |
nitrocellulose strips with the blotted proteins were incubated with the detergents and sera from human volunteers vaccinated with meningococcal membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
39,
47
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
144,
161
]
} |
sera of pbc patients were also tested in immunoblotting against rat liver subcellular fractions including mitoplasts , submitochondrial particles , inner membrane , outer membrane , matrix proteins and inter-membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
189,
197
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
208,
225
]
} |
antigenic bands of a and b zones were localized in the inner membrane and/or in the matrix proteins and the 35 kda band in inter-membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
91,
99
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
129,
146
]
} |
the position of the antigenic determinant could be established in more detail using partial chemical degradation of the original antigen using information about the maximal length of a fragment which has lost its ability to interact with the monoclonal antibody . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
20,
41
]
} | {
"id": "C0018593",
"name": "partial",
"pos": [
84,
91
]
} |
epidermal keratinocytes in culture from the same subjects were exposed to uvc with doses chosen to elicit comparable yields of dimers in cellular dna . | NA | {
"id": "C0022567",
"name": "culture",
"pos": [
27,
34
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
137,
145
]
} |
the use of monoclonal antibodies to detect single-stranded dna in alkaline sucrose gradients may be of value in a variety of studies involving human tissues in which it is not possible to use radioactive labeling of the dna for the analysis . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
43,
62
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
220,
223
]
} |
the involved areas from psoriasis patients contained a statistically significant seven- to 11-fold increase in the levels of leukotriene b4 , 13-hydroxyoctadecadienoic acid-like compound , 15-hydroxyeicosatetraenoic acid compound and 12-hydroxyeicosatetraenoic acid in comparison to normal samples and a three- to sevenf... | NA | {
"id": "C0020349",
"name": "hydroxyeicosatetraenoic acid",
"pos": [
192,
220
]
} | {
"id": "C0044800",
"name": "12-hydroxyeicosatetraenoic acid",
"pos": [
234,
265
]
} |
tumor promoting phorbol esters , such as 12-0-tetradecanoylphorbol-13-acetate ( tpa ) , when applied topically to mouse skin cause inflammation and hyperplasia . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
16,
30
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
46,
66
]
} |
in search for a rationale for the use of interferons ( ifns ) in treatment of non-hodgkin lymphoma ( nhl ) , we have investigated the ifn system of 13 patients with low-grade nhl , 15 patients with high-grade nhl , and 20 patients with chronic lymphocytic leukemia or leukemic immunocytoma ( cll/ic ) . | NA | {
"id": "C0079747",
"name": "low-grade nhl",
"pos": [
165,
178
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
209,
212
]
} |
further support to the involvement of g proteins in ifn-gamma transduction signal came from the finding that a non-hydrolizable gtp analog , gtp-gamma-s , enhanced in the presence of phorbol esters ( pma ) the antiviral and antiproliferative activity of ifn-gamma , but not of ifn-alpha/beta . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
128,
131
]
} | {
"id": "C0079469",
"name": "gtp-gamma-s",
"pos": [
141,
152
]
} |
further support to the involvement of g proteins in ifn-gamma transduction signal came from the finding that a non-hydrolizable gtp analog , gtp-gamma-s , enhanced in the presence of phorbol esters ( pma ) the antiviral and antiproliferative activity of ifn-gamma , but not of ifn-alpha/beta . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
183,
197
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
200,
203
]
} |
carcinoma cells from colon ( widr ) and lung ( a-549 ) were compared to fibroblasts ( ag-1522 ) and primary explants of umbilical vein endothelial cells ( huvec ) in terms of their response to a 20 min heat shock at 45 degrees c . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} |
combining conductivity measurements and molecular weight determination by means of low-angle laser light scattering , we have found for the polyribonucleotides ( polyuridylic acid ( poly ( u ] , polyadenylic acid ( poly ( a ] , polycytidylic acid ( poly ( c ] and polyguanylic acid ( poly ( g ] and for single-stranded d... | NA | {
"id": "C0032590",
"name": "polyribonucleotides",
"pos": [
140,
159
]
} | {
"id": "C0032411",
"name": "polyguanylic acid",
"pos": [
264,
281
]
} |
the radical spectra of mixtures of thymidine 5'-monophosphate ( tmp ) or uridine 5'-monophosphate ( ump ) with adenine 5'-monophosphate ( amp ) after hydrated electron attack , measured from 5 to 3000 microsecond after pulse radiolysis , can only be described in terms of the radical spectra of the nucleotides if an ele... | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
111,
118
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
366,
372
]
} |
membrane lipid composition and fluidity of a series of b16 melanoma cell variants with increased resistance to heat were analysed for changes within the lipid component that may contribute to the acquisition of heat resistance . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
0,
14
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
153,
158
]
} |
factors that carry a poor prognosis include osteolysis of fractured fragments , subungual haematomas and non-union of fractures . | NA | {
"id": "C0016658",
"name": "fractured",
"pos": [
58,
67
]
} | {
"id": "C0016665",
"name": "non-union",
"pos": [
105,
114
]
} |
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