text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
rabbit antiprogesterone antiserum and peroxidase conjugated goat antirabbit antiserum were used as a primary and secondary antibody respectively . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
24,
33
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
123,
131
]
} |
to study changes in glutathione redox status as an indicator of oxidant stress during hypoxia and reoxygenation , we perfused isolated rat lungs with a high or low oxygen perfusate and measured the release of total glutathione and glutathione disulfide ( gssg ) into the perfusate . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
20,
31
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
255,
259
]
} |
the 8 kb apob mrna form may correspond to the apob-48 mrna , whereas the apoa-iv- and apoc-ii-related mrna species have not been described previously . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
9,
13
]
} | {
"id": "C0103839",
"name": "apob-48",
"pos": [
46,
53
]
} |
this study provides a comprehensive survey of the sites of apolipoprotein gene expression and shows numerous differences in both the abundance and the tissue distribution of several apolipoprotein mrnas between rabbit and human tissues . | NA | {
"id": "C0003592",
"name": "a",
"pos": [
20,
21
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
182,
196
]
} |
taken together , the results indicate that 1 ) digestion of ldl by purified pmn elastase results in a greater mass of ed-ldl ( relative to native ldl ) being degraded per unit time by hmd-m ; | NA | {
"id": "C0064833",
"name": "pmn elastase",
"pos": [
76,
88
]
} | {
"id": "C0030306",
"name": "ed-ldl",
"pos": [
118,
124
]
} |
when applied to the isolation of apoa-iv from a crude protein mixture obtained by incubation of phospholipid-triglyceride emulsion particles with lipoprotein-depleted plasma , the technique yielded a single peak of highly pure apoa-iv cleanly separated from isoforms of apoa-i and higher molecular weight proteins . | NA | {
"id": "C0597298",
"name": "isoforms",
"pos": [
258,
266
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
305,
313
]
} |
when the flow of tyrode 's solution was resumed ( reperfusion ) , force markedly increased ( +211.1 % ) and oscillatory potentials initiated arrhythmias ( extrasystoles and repetitive fast discharge ) in 64 % of tests . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
141,
152
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
155,
168
]
} |
the relative biological potencies of mezerein and the phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , to inhibit thyroid function in vitro corresponded to their abilities to activate pkc . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
54,
67
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
70,
106
]
} |
several dideoxynucleosides have been shown to have potent in vitro and , in the case of 3'-azido-2',3'-dideoxythymidine ( azt ) and 2',3'-dideoxycytidine ( ddc ) , in vivo activity against hiv . | NA | {
"id": "C0012136",
"name": "dideoxynucleosides",
"pos": [
8,
26
]
} | {
"id": "C0043474",
"name": "azt",
"pos": [
122,
125
]
} |
in the present study , we observed that htlv-iiiba-l replication in fresh human peripheral blood monocyte/macrophages was suppressed by each of three dideoxynucleosides : 3'-azido-2',3'-dideoxythymidine ( azt ) , 2',3'-dideoxycytidine ( ddc ) , and 2',3'-dideoxyadenosine ( dda ) . | NA | {
"id": "C0012136",
"name": "dideoxynucleosides",
"pos": [
150,
168
]
} | {
"id": "C0043474",
"name": "azt",
"pos": [
205,
208
]
} |
these results suggest that the ratio of dideoxynucleoside triphosphate to normal deoxynucleoside triphosphate is a crucial factor in determining the antiviral activity of dideoxynucleosides in hiv target cells , and that the lower levels of dttp may account for the antiretroviral activity of azt in the face of inefficient phosphorylation of this compound . | NA | {
"id": "C0012136",
"name": "dideoxynucleosides",
"pos": [
171,
189
]
} | {
"id": "C0043474",
"name": "azt",
"pos": [
293,
296
]
} |
in addition , cr1 could not be detected immunologically on marmoset or human ebv-expressing cells and mabs to cr1 failed to alter ebv-produced decay acceleration and factor i cofactor activities , although the antibodies blocked the same cr1-dependent functional activities . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
102,
106
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
210,
220
]
} |
5f11 crossreacts with heparan sulfate and phosphorylcholine , while 10g6 did not crossreact with any glycosaminoglycans or phosphorylated compounds tested . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
22,
37
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
101,
119
]
} |
for both proteins , presentation is partially ( np ) or completely ( ha ) restored by expression of rapidly degraded protein fragments in the vaccinia infected target cell . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
9,
17
]
} | {
"id": "C0028612",
"name": "np",
"pos": [
48,
50
]
} |
cytoadherent irbcs from two different cloned isolates had large ( mr greater than 2.4 x 10 ( 5 ) radioiodinatable proteins that differed in size between the isolates but had in common the biochemical properties of trypsin sensitivity and insolubility with triton x-100 . the proteins were not detected with uninfected erythrocytes , indicating that they were parasite determined , nor were they detected with irbcs containing parasites cultured for many months without selection . with continued selection for the cytoadherent phenotype , additional irbc surface proteins with larger molecular sizes ( mr 2.9 x 10 ( 5 ) and 3.2 x 10 ( 5 ] appeared . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
114,
122
]
} | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
555,
571
]
} |
drowning accounted for 19 % of deaths , and 17 % of patients died of other contributory causes such as suicide , exposure , or atherosclerotic coronary vascular disease . | NA | {
"id": "C0013142",
"name": "drowning",
"pos": [
0,
8
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
61,
65
]
} |
using planar bilayer recording techniques , we show that the purified receptor forms cationic channels selective for divalent ions . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
85,
93
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
126,
130
]
} |
one of these proteases , tissue-destructive protease ( tdp ) destroyed completely the trypsin-inhibitory capacity of alpha-1-at at protease : inhibitor molar ratios down to 0.002:1 . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
13,
22
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
131,
139
]
} |
monoclonal antibodies ( mabs ) were complexed to solid matrices and used to purify virus proteins from simian virus 5 ( sv5 ) -infected tissue culture cells , ideally in such a way as to bind equimolar amounts of antigen to antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
224,
232
]
} |
however , immunization with smaa complexes resulted in relatively less antibody being produced to the antigenic determinant through which the protein is coupled , via antibody , to the smaa complex compared with the amount of antibody produced against other antigenic determinants on that protein . | NA | {
"id": "C0003313",
"name": "smaa complex",
"pos": [
28,
40
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
226,
234
]
} |
prior immunization of mice with solid matrix-antibody-antigen ( smaa ) complexes containing either surface or internal virus structural proteins reduced the amount of virus replication within infected lungs , the greatest degree of protection being observed when nucleoprotein or matrix protein was used to immunize the mice . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
263,
276
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
287,
294
]
} |
thus it appears that human erythrocytes have a low level of o-acetylated sialic acid-containing glycoconjugates that can interact specifically with the he glycoprotein of influenza c virus . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
96,
111
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
155,
167
]
} |
this rna has a single open reading frame spanning the length of the genome in the viral rna sense ( positive polarity ) , implying an expression strategy involving the processing of a precursor polyprotein . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
5,
8
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
82,
91
]
} |
a solid-phase enzyme-linked immunosorbent assay ( elisa ) with monoclonal secondary antibodies was used to detect matrix protein and nucleoprotein of influenza a . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
121,
128
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
133,
146
]
} |
the sensitivity of the elisa for highly purified a/brazil nucleoprotein and matrix protein was 0.05 and 1.0 ng , respectively . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
58,
71
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
83,
90
]
} |
these findings demonstrate that therapeutically relevant concentrations of inhalation anesthetics perturb the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex , and suggest this oligomeric protein may be a common mediator of some aspects of anesthetic action . | NA | {
"id": "C0242903",
"name": "inhalation anesthetics",
"pos": [
75,
97
]
} | {
"id": "C0002932",
"name": "anesthetic",
"pos": [
265,
275
]
} |
the inhibitory action of gaba on the response to histamine was mimicked by the gabab agonist ( - ) -baclofen , ic50 0.69 +/- 0.04 microm , which was 430-fold more potent as an inhibitor than the ( + ) -isomer . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
25,
29
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
100,
108
]
} |
inhibition curves for gaba and for ( - ) -and and ( + ) -baclofen had hill coefficients greater than unity . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
22,
26
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
57,
65
]
} |
isoprenaline , adrenaline , salbutamol , and noradrenaline increased cyclic amp content with ka values of 0.13 , 0.12 , 0.22 , and 7.60 microm . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
45,
58
]
} |
furthermore , the dopamine receptor expressed by d384 cells exhibits a pharmacological profile typical of a mammalian striatal d1-receptor and therefore the use of this clone represents another approach to studying central d1-receptors . | NA | {
"id": "C0034798",
"name": "dopamine receptor",
"pos": [
18,
35
]
} | {
"id": "C0058697",
"name": "d1-receptors",
"pos": [
223,
235
]
} |
dopamine-induced dispersion was inhibited by the d2 dopaminergic antagonist sulpiride but not by d1 or alpha-adrenergic antagonists . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
0,
8
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
52,
64
]
} |
the order of potency for adenosine analogues was as follows : l-n6-phenylisopropyladenosine greater than n6-cyclohexyladenosine greater than d-n6-phenylisopropyladenosine approximately equal to 2-chloroadenosine greater than adenosine much greater than 5'-n-ethylcarboxamidoadenosine . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
67,
91
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
274,
283
]
} |
the order of potency for adenosine analogues was as follows : l-n6-phenylisopropyladenosine greater than n6-cyclohexyladenosine greater than d-n6-phenylisopropyladenosine approximately equal to 2-chloroadenosine greater than adenosine much greater than 5'-n-ethylcarboxamidoadenosine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
25,
34
]
} | {
"id": "C0050789",
"name": "n-ethylcarboxamidoadenosine",
"pos": [
256,
283
]
} |
neither adenosine , l-n6-phenylisopropyladenosine , nor 8-phenyltheophylline affected the release of glutamate or aspartate evoked by 10 microm veratridine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
8,
17
]
} | {
"id": "C0031484",
"name": "l",
"pos": [
102,
103
]
} |
recombinant interferon alfa-2a in metastatic renal cell carcinoma : assessment of antitumor activity and anti-interferon antibody formation . | NA | {
"id": "C0021734",
"name": "recombinant interferon alfa-2a",
"pos": [
0,
30
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
110,
120
]
} |
median time to the development of antibody as measured by eia or na was 8 and 14 weeks , respectively . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
34,
42
]
} | {
"id": "C0475463",
"name": "na",
"pos": [
65,
67
]
} |
it can be incorporated into rna leading to interference with the maturation of nuclear rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
28,
31
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
79,
90
]
} |
from the results we concluded that 75 % of lha glucose-sensitive neurons receive inhibitory serotonin inputs from the dr through serotonin 1 receptors , and 20 % of glucose-insensitive neurons receive excitatory inputs from the dr through serotonin 2 receptors though 41 % of these receive inhibitory inputs through serotonin 1 receptor . | NA | {
"id": "C0036757",
"name": "serotonin 2 receptors",
"pos": [
239,
260
]
} | {
"id": "C0034838",
"name": "serotonin",
"pos": [
316,
325
]
} |
flow pipes were used to rapidly exchange the extracellular solution , and to apply n-methyl-d-aspartic acid ( nmda ) and some nmda antagonists . | NA | {
"id": "C0079883",
"name": "n-methyl-d-aspartic acid",
"pos": [
83,
107
]
} | {
"id": "C0004015",
"name": "nmda",
"pos": [
126,
130
]
} |
however , raising the extra-cellular glycine concentration , from 1 microm to 1 mm , reduced the potency of 100 microm kynurenic acid as an nmda antagonist , suggesting that kynurenate has an additional action as a competitive antagonist at the glycine modulatory site on nmda receptor channels . | NA | {
"id": "C0004015",
"name": "nmda",
"pos": [
140,
144
]
} | {
"id": "C0949755",
"name": "nmda",
"pos": [
272,
276
]
} |
the bp in the 45k complex was about 5-fold more sensitive to competition with unlabeled sm/igfs than the bp in the 40k complex , suggesting that it either has a higher affinity for sm/igfs or is less abundant . | NA | {
"id": "C0021666",
"name": "a",
"pos": [
27,
28
]
} | {
"id": "C0037657",
"name": "sm/igfs",
"pos": [
181,
188
]
} |
protein iiia ( mr approximately 74,000 ) and protein iiib ( mr approximately 55,000 ) , referred to collectively as protein iii , are synaptic vesicle-associated phosphoproteins found in all regions of the rat nervous system and in the rat adrenal medulla . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
162,
177
]
} |
glycosaminoglycans ( gags ) with electrophoretic mobilities on cellulose acetate similar to heparin ( h ) , heparan sulfate ( hs ) , and chondroitin sulfate ( cs ) were detected in cell extracts and in conditioned medium of high-density , neuron-enriched cultures labeled with 35so4 . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
0,
18
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
92,
99
]
} |
glycosaminoglycans ( gags ) with electrophoretic mobilities on cellulose acetate similar to heparin ( h ) , heparan sulfate ( hs ) , and chondroitin sulfate ( cs ) were detected in cell extracts and in conditioned medium of high-density , neuron-enriched cultures labeled with 35so4 . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
0,
18
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
108,
123
]
} |
in the presence of beta-d-xyloside , an inhibitor of proteoglycan assembly , there was an increase of released gags with the mobility of cs and heavily sulfated hs but a decrease in neurite outgrowth activity on a laminin substrate at times greater than 14 hr . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
111,
115
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
161,
163
]
} |
g-protein activation by receptors was confirmed by dialysis with low concentrations of gtp gamma s in competition with gtp . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
87,
98
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
119,
122
]
} |
here we report the characterization of nicotinic achrs of bovine and human brain using as probes mabs prepared to achrs from rat brain . | NA | {
"id": "C0034830",
"name": "nicotinic achrs",
"pos": [
39,
54
]
} | {
"id": "C0034792",
"name": "achrs",
"pos": [
114,
119
]
} |
the rate of tdr uptake ( mean +/- s.d . ) was of 0.009 +/- 0.006 mumol.100 cc-1.min-1 in low-grade nhl . | NA | {
"id": "C0079747",
"name": "low-grade",
"pos": [
89,
98
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
99,
102
]
} |
the relation between mechanical loading of cartilage and chondrocyte activity in vivo may be mediated by several physical transduction mechanisms including : cell deformation , hydrostatic pressure gradients , fluid flow , streaming currents , and physicochemical changes . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
158,
162
]
} |
collagen type ii was distributed throughout the growth plate , providing a framework within which chondrocytes divided and formed clusters of differentiating ( hypertrophic ) cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
98,
110
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
175,
180
]
} |
we now report the characterization of a second type of somatomedin receptor on these cells that is more specific for another class of somatomedin represented by multiplication-stimulating activity ( msa ) or rat insulin-like growth factor ii ( rigf-ii ) . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
55,
66
]
} | {
"id": "C0021666",
"name": "insulin-like growth factor ii",
"pos": [
212,
241
]
} |
in all groups the ratio of protein accretion to fat accretion reflected dietary proportions of protein and energy . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
27,
34
]
} | {
"id": "C0012177",
"name": "dietary",
"pos": [
72,
79
]
} |
of the latter , the best substrates were those with phenylalanine , leucine , alanine , methionine or arginine ( i.e . amino acids with hydrophobic or basic side chains ) in the p1 position . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
58,
65
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
119,
130
]
} |
the specificity profiles of the proteolytic enzymes corresponded best to those of some well characterized serine proteinases ( chymotrypsin , elastase ) . | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
32,
51
]
} | {
"id": "C2717971",
"name": "serine",
"pos": [
106,
112
]
} |
the increase in serum protein binding of phenytoin in the growth process of rats was caused by changes in both serum albumin concentration and binding parameters of phenytoin to serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
117,
124
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
178,
191
]
} |
computer analysis of plasma 14c-mt kinetics showed a three-compartment system with half-lives of 0.21 +/- 0.05 , 5.97 +/- 1.11 , and 47.52 +/- 8.86 min . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
35,
43
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
83,
93
]
} |
the partition and solubility methods were used to assess the dissociation constants of carbenoxolone , while the pka of the structurally related triterpenoid , enoxolone ( 2 ) was determined using a spectrophotometric method . | NA | {
"id": "C0006979",
"name": "carbenoxolone",
"pos": [
87,
100
]
} | {
"id": "C0017986",
"name": "enoxolone",
"pos": [
160,
169
]
} |
similarly , 80-90 % of the hydrolysis of d-ala2- [ l-leu ] enkephalin ( dalle ) is due to the combined action of aminopeptidase m and angiotensin converting enzyme , whereas aminopeptidase mii and enkephalinase activity against this substrate also could not be detected . | NA | {
"id": "C0054943",
"name": "aminopeptidase m",
"pos": [
113,
129
]
} | {
"id": "C0002570",
"name": "aminopeptidase",
"pos": [
174,
188
]
} |
among other alternatives , it is suggested that enkephalin hydrolysis in plasma may appear to be unique because of differences in enzyme conformation and/or the availability of a substance ( s ) that competes with , or alters the binding of , [ leu ] enkephalin , dalle or the inhibitors to the enzymes . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
48,
58
]
} | {
"id": "C0014294",
"name": "leu",
"pos": [
245,
248
]
} |
in rats with a unilateral lesion of the nigrostriatal dopaminergic pathway , the ipsilateral rotation produced by the enhanced actions of endogenous dopamine ( da ) on the nonlesioned side , induced by either the da-releasing drug amphetamine or the da uptake inhibitor gbr 13069 , was blocked effectively by pretreatment with either the selective d1 da receptor antagonist , sch 23390 , or the d2 selective antagonist , haloperidol . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
54,
66
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
149,
157
]
} |
when ly 83583 was added to the glutathione-containing gc-assay or to the superfusate from cultured endothelial cells , it did not affect stimulation of soluble gc by edrf but it slowly reversed the dilator response of the arterial detector segment . | NA | {
"id": "C0018358",
"name": "gc",
"pos": [
54,
56
]
} | {
"id": "C1097411",
"name": "soluble gc",
"pos": [
152,
162
]
} |
since mepiperphenidol blocked the gentamicin-induced ca2+ increases , the data suggest that aminoglycosides enter the cell via the organic cation transporter . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
34,
44
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
92,
107
]
} |
the role of rat calcitonin gene-related peptide ( cgrp ) , a recently characterized vasoactive neuropeptide , in cardiovascular regulation was studied in the conscious rat . | NA | {
"id": "C0006669",
"name": "calcitonin gene-related peptide",
"pos": [
16,
47
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
95,
107
]
} |
adenosine , adenosine 5'-monophosphate ( amp ) , adenosine 5'-diphosphate ( adp ) , atp and alpha , beta-methylene atp ( apcpp ) produced small positive inotropic effects , sometimes preceded by transient negative effects . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
115,
118
]
} |
adenosine , adenosine 5'-monophosphate ( amp ) , adenosine 5'-diphosphate ( adp ) , atp and alpha , beta-methylene atp ( apcpp ) produced small positive inotropic effects , sometimes preceded by transient negative effects . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
12,
23
]
} | {
"id": "C0001459",
"name": "adenosine",
"pos": [
49,
58
]
} |
adenosine , adenosine 5'-monophosphate ( amp ) , adenosine 5'-diphosphate ( adp ) , atp and alpha , beta-methylene atp ( apcpp ) produced small positive inotropic effects , sometimes preceded by transient negative effects . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
12,
23
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
115,
118
]
} |
adenosine and atp increased inositol 1 , 4 , 5- and inositol 1 , 3 , 4-trisphosphate as well as inositol mono- and bisphosphate formation . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
14,
17
]
} |
apcpp increased inositol phosphate formation while 8-pt did not prevent the effects of adenosine and atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
87,
96
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
101,
104
]
} |
radiation-induced fluorescence changes of 2'-deoxycytidine and cytidilyl-cytidine in aqueous solution . comparison with radiolytic behaviors of other nucleobase derivatives . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
45,
58
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
73,
81
]
} |
amino acid analysis of this glycoprotein shows that it is rich in isoleucine , glycine , glutamine and proline , while methionine , tyrosine and asparagine are present in traces . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
79,
86
]
} |
marked inhibition was seen at concentrations of auranofin ( af ) and gold sodium thiomalate ( gstm ) that correspond to gold levels found in the serum of patients receiving these drugs . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
48,
57
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
120,
124
]
} |
marked inhibition was seen at concentrations of auranofin ( af ) and gold sodium thiomalate ( gstm ) that correspond to gold levels found in the serum of patients receiving these drugs . | NA | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
69,
91
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
120,
124
]
} |
auranofin ( af ) , a gold containing complex used in the treatment of rheumatoid arthritis , is a potent inhibitor of the macrophage respiratory burst . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
0,
9
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
21,
25
]
} |
further , supernatant from mcm stimulated chondrocytes , incubated with dead cartilage explants for 3 days , did not significantly increase proteoglycan release above the background level of cartilage alone ( 7-10 % ) , nor did the addition of 5 x 10 ( 4 ) pec to cultures of dead cartilage explants plus supernatant from mcm stimulated chondrocytes make any significant difference , indicating that supernatant from mcm stimulated chondrocytes and pec alone had negligible cartilage proteoglycan degrading activity in these experiments . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
42,
54
]
} | {
"id": "C0007634",
"name": "pec",
"pos": [
449,
452
]
} |
the inclusion of 0.1 mm apma or 0.2 u/ml plasminogen in cultures of dead cartilage explants plus supernatant from mcm stimulated chondrocytes , however , increased proteoglycan release to 80-93 % , with or without pec . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
129,
141
]
} | {
"id": "C0007634",
"name": "pec",
"pos": [
214,
217
]
} |
the differential hydrogen bond effect observed in most correlations of rplc data with logarithms of octanol-water partition coefficients ( log po/w ) for compounds of opposite net hydrogen bonding capabilities ( noncongeners ) was minimized by adding trace quantities of n-decylamine and 1-octanol to the eluent and using an octyl-modified silica gel stationary phase . | NA | {
"id": "C0001979",
"name": "octanol",
"pos": [
100,
107
]
} | {
"id": "C0044551",
"name": "1-octanol",
"pos": [
288,
297
]
} |
antisera were raised by immunising rabbits with cells of 10 selected strains , followed by absorption of non-specific antibodies . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
118,
128
]
} |
increased levels of platelet associated igg have been found in 30 % of patients with insulin dependent ( type 1 ) diabetes mellitus , closely associated with the simultaneous presence in the serum of insulin antibodies and immune complexes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
208,
218
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
223,
239
]
} |
under conditions of an outwardly directed oh- gradient , dids-sensitive folate uptake was cis inhibited ( greater than 90 % ) by reduced folate analogues : dihydrofolate ( ic50 = 0.40 microm ) , folinic acid ( ic50 = 0.50 microm ) , 5-methyltetrahydrofolate ( ic50 = 0.53 microm ) , and ( + ) amethopterin ( ic50 = 0.93 microm ) . | NA | {
"id": "C3536866",
"name": "folate analogues",
"pos": [
137,
153
]
} | {
"id": "C0023413",
"name": "folinic acid",
"pos": [
195,
207
]
} |
the effect of increasing chloride concentration on the inhibitory potency of hnpg is consistent with the concept that cl- and hnpg compete for the same site on the anion transporter . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
25,
33
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
164,
169
]
} |
partial inactivation of the transport system with phenylglyoxal lowers the maximal rates of so4 ( 2- ) and chloride exchange but does not modify the apparent ks for the substrate anions . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
107,
115
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
179,
185
]
} |
the mutant protein , cre111 , carries out recombination at a much slower rate than the wild-type cre protein . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
4,
18
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
101,
108
]
} |
we demonstrated that the ompc transcription was activated in an ompr-dependent manner even when the cis-acting upstream sequence was separated from the -35 and -10 regions by several turns of the dna helix , providing that the distance between them was a near-integral multiple of one turn of the dna helix . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
196,
199
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
299,
300
]
} |
however , when mel-14 cells were treated with ndv strain 73-t , both rhutnf-alpha and supernatants from ndv-stimulated pbmcs killed 48 % and 55 % , respectively , of these tumor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C1321301",
"name": "pbmcs",
"pos": [
119,
124
]
} |
patients with hypoalbuminemia and hypoproteinemia are at increased risk of experiencing severe or life-threatening toxic effects from trimetrexate and should be treated cautiously . | NA | {
"id": "C0239981",
"name": "hypoalbuminemia",
"pos": [
14,
29
]
} | {
"id": "C0020639",
"name": "hypoproteinemia",
"pos": [
34,
49
]
} |
these observations suggest that both mdr and cytochrome p-450 gene families are evolutionarily selected by the capacity of various xenobiotics to induce their own detoxification either through metabolism to hydrophilic derivatives by the cytochrome p-450 system or direct excretion from the cell by the mdr gene family . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
193,
203
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
272,
281
]
} |
in this report we describe the isolation of a metalloproteinase exhibiting both type iv collagenolytic and gelatinolytic activities from the conditioned medium of nih-3t3 fibroblasts transformed with dna containing an activated c-harvey-ras oncogene from t24 bladder cancer cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
171,
182
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
274,
279
]
} |
the significant inhibition of adenylate cyclase observed with plictran might be due to the tin component , since several heavy metals affect camp metabolism . | NA | {
"id": "C0040238",
"name": "tin component",
"pos": [
91,
104
]
} | {
"id": "C0347988",
"name": "heavy",
"pos": [
121,
126
]
} |
two of these , possibly a lipoprotein and a mucoprotein , increase gc levels , whereas the third , probably a glycoprotein , exerts an inhibitory effect . | NA | {
"id": "C0026714",
"name": "mucoprotein",
"pos": [
44,
55
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
110,
122
]
} |
in order to evaluate the long-term-safety of uft which contained tegafur [ 1- ( 2-tetrahydrofuryl ) -5-fluorouracil , ft-207 ] and uracil in molar ratio of 1:4 , a nine-month chronic toxicity study was performed in dogs . | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
65,
72
]
} | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
101,
115
]
} |
in order to evaluate the long-term-safety of uft which contained tegafur [ 1- ( 2-tetrahydrofuryl ) -5-fluorouracil , ft-207 ] and uracil in molar ratio of 1:4 , a nine-month chronic toxicity study was performed in dogs . | NA | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
101,
115
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
131,
137
]
} |
three control drugs , ft-207 , uracil and 5-fu , were also included in present experiment at doses of 7.5 , 420.0 and 5.0 mg/kg , respectively . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
31,
37
]
} | {
"id": "C0016360",
"name": "5-fu",
"pos": [
42,
46
]
} |
in an attempt to quantify this risk , the records of 1,272 consecutive patients with blunt injuries admitted to a level i regional trauma center were reviewed . | NA | {
"id": "C0043253",
"name": "blunt injuries",
"pos": [
85,
99
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
131,
137
]
} |
these tubules appear to be composed of only one type of protein , ns1 , a major nonstructural protein of the virus . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} | {
"id": "C0042736",
"name": "protein",
"pos": [
94,
101
]
} |
the immunoreactivity of the p16 ( ma ) protein with region-specific gag antisera and the conservation of the n-terminal myristyl group of the p55 precursor protein in p16 ( ma ) confirmed its position as the n-terminal-most protein . | NA | {
"id": "C0032583",
"name": "p55",
"pos": [
142,
145
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
224,
231
]
} |
the immunoreactivity of the p16 ( ma ) protein with region-specific gag antisera and the conservation of the n-terminal myristyl group of the p55 precursor protein in p16 ( ma ) confirmed its position as the n-terminal-most protein . | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
146,
163
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
224,
231
]
} |
markedly reduced nucleoprotein levels and undetectable amounts of glycoprotein precursor and l protein were synthesized at the nonpermissive temperature in cells infected with five of the mutants . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
17,
30
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
95,
102
]
} |
analysis of viral rna with radiolabeled single-stranded cdna probes representing complementary and genomic-sense sequences corresponding to the 3 ' region of s rna revealed two basic patterns of viral rna synthesis . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
18,
21
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
195,
204
]
} |
in addition to the activation of the hiv ltr , hsv induction of nf-kappa b activity may be important for the regulation of hsv gene expression during a herpesvirus infection . | NA | {
"id": "C0019348",
"name": "hsv",
"pos": [
47,
50
]
} | {
"id": "C0019372",
"name": "herpesvirus",
"pos": [
152,
163
]
} |
simian immunodeficiency virus ( siv ) was isolated from the total peripheral blood mononuclear cell population and the monocyte-macrophage adherent cell population of three seropositive green monkeys originating from kenya . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
66,
82
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
115,
118
]
} |
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