text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
restricted replication of hepatitis a virus in cell culture : encapsidation of viral rna depletes the pool of rna available for replication . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
79,
88
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
110,
113
]
} |
intracellular viral rna was further analyzed by using 2 m licl to fractionate the insoluble nonvirion 35s rna and replicative intermediates ( ri ) from the soluble virions and double-stranded replicative forms , in conjunction with sucrose density gradient ultracentrifugation to separate the different forms of viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
20,
23
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
312,
321
]
} |
the arginine at position 17 of vpg could not be exchanged with any other amino acid without loss of viability , whereas the lysine at position 20 , an amino acid conserved among all known polioviruses , coxsackieviruses , and echoviruses , was replaceable with several neutral amino acids and even with glutamic acid . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
73,
83
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
269,
288
]
} |
analysis of viral dna by electron microscopy and sucrose gradients confirmed that the presence of uv-induced lesions severely blocks dna synthesis , and thus the conversion of replicative intermediates ( ris ) into fully replicated form i dna is inhibited by uv irradiation . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
12,
21
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
239,
242
]
} |
these results indicate that dna containing human papillomavirus type 16 open reading frames e6 and e7 isolated from the genome of a human tumor has transforming potential , that this potential is realized when the viral dna is joined to cellular sequences , and that the cellular sequences function in a more complex way than by simply providing polyadenylation signals . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
28,
31
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
214,
223
]
} |
plasma and tumour concentrations of estramustine , estromustine , estradiol and estrone , the major metabolites of estramustine phosphate ( estracyt ) , were determined in patients with prostatic carcinoma treated between one and nine years with repeated oral doses of estracyt ( 560 to 840 mg./day ) . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
36,
48
]
} | {
"id": "C0014912",
"name": "estradiol",
"pos": [
66,
75
]
} |
estromustine was the main metabolite in plasma as well as in the tumour ( range 235 to 450 and 205 to 485 ng./gm. , respectively ) , whereas estramustine ( 20 to 45 ; 95 to 370 ) , estrone ( 62 to 140 ; 63 to 160 ) and estradiol ( 8 to 15 ; 7 to 36 ) were found in lower concentrations . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
141,
153
]
} | {
"id": "C0014912",
"name": "estradiol",
"pos": [
219,
228
]
} |
since the pathologist will detect more tumors and cysts than the radiologist , these figures probably are an underestimate of the true incidence . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
39,
45
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
50,
55
]
} |
the stability of phentolamine mesylate in aqueous solution and in solution with papaverine ( 0.83 mg. per cc phentolamine and 25 mg. per cc papaverine ) was ascertained by high performance liquid chromatography and gas chromatography with mass spectrometry . | NA | {
"id": "C0733398",
"name": "phentolamine mesylate",
"pos": [
17,
38
]
} | {
"id": "C0031448",
"name": "phentolamine",
"pos": [
109,
121
]
} |
in four patients , two with iliac artery aneurysms and two with popliteal artery aneurysms , the associated aneurysm was not identified . | NA | {
"id": "C0162870",
"name": "iliac artery aneurysms",
"pos": [
28,
50
]
} | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
108,
116
]
} |
[ studies on the metabolic fate of 14c-rokitamycin . absorption , distribution , metabolism and excretion in infant rats ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
81,
91
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
96,
105
]
} |
14c-rokitamycin ( rkm ) at the dose of 200 mg/kg was administered orally to fasted infant rats to study the absorption , distribution , metabolism and excretion in infant animals . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
136,
146
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
151,
160
]
} |
against s. pyogenes , beta-lactam antibiotics ( beta-lactams ) and rkm had mic80 of 0.20 microgram/ml or below , and no resistant strains of this organism were observed against these antibiotics . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
22,
45
]
} | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
48,
60
]
} |
therapeutic responses were recorded as excellent or good in 22 ( 73.3 % ) of the children , comprising 6 with tonsillitis , 2 with pharyngitis , 4 with bronchitis , 1 with bronchopneumonia , 1 with mycoplasma pneumonia , 2 with whooping cough , 5 with streptococcal infections , 5 with campylobacter enteritis , 3 with impetigo and 1 with ssss . | NA | {
"id": "C0040425",
"name": "tonsillitis",
"pos": [
110,
121
]
} | {
"id": "C0031350",
"name": "pharyngitis",
"pos": [
131,
142
]
} |
clinical and bacteriological effects of rkm were evaluated for 175 patients including 5 cases of pharyngitis , 3 tonsillitis , 32 pneumonia , 17 mycoplasmal pneumonia , 34 atypical pneumonia , 28 streptococcal infections , 29 campylobacter enteritis , 4 salmonella gastroenteritis , and 23 enteritis due to unknown organisms . | NA | {
"id": "C0031350",
"name": "pharyngitis",
"pos": [
97,
108
]
} | {
"id": "C0040425",
"name": "tonsillitis",
"pos": [
113,
124
]
} |
values of alpha 1-acid glycoprotein ( alpha 1-ag ) , haptoglobin ( hp ) and c-reactive protein ( crp ) were measured as the factors of apr before and after the operation . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
10,
35
]
} | {
"id": "C0001347",
"name": "apr",
"pos": [
135,
138
]
} |
values of alpha 1-acid glycoprotein ( alpha 1-ag ) , haptoglobin ( hp ) and c-reactive protein ( crp ) were measured as the factors of apr before and after the operation . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
53,
64
]
} | {
"id": "C0001347",
"name": "apr",
"pos": [
135,
138
]
} |
values of alpha 1-acid glycoprotein ( alpha 1-ag ) , haptoglobin ( hp ) and c-reactive protein ( crp ) were measured as the factors of apr before and after the operation . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
76,
94
]
} | {
"id": "C0001347",
"name": "apr",
"pos": [
135,
138
]
} |
a 30 year old man with didmoad ( diabetes insipidus , diabetes mellitus , optic atrophy and deafness ) syndrome associated with myocardial disease is reported . | NA | {
"id": "C0043207",
"name": "didmoad",
"pos": [
23,
30
]
} | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
33,
51
]
} |
the recurrent type was detected less often than the untreated malignant lymphoma , and there was no significant difference in detectability between hodgkin 's disease and non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
62,
80
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
148,
166
]
} |
the recurrent type was detected less often than the untreated malignant lymphoma , and there was no significant difference in detectability between hodgkin 's disease and non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
62,
80
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
171,
194
]
} |
[ the dysfunction of human thyroid stimulating hormone ( htsh ) due to tsh beta subunit gene abnormality ] . | NA | {
"id": "C0040160",
"name": "thyroid stimulating hormone",
"pos": [
27,
54
]
} | {
"id": "C0076641",
"name": "tsh beta",
"pos": [
71,
79
]
} |
2 ) the first cluster had significantly high frequencies of abnormal values of glutamic oxalacetic transaminase ( got ) and glutamic pyruvic transaminase ( gpt ) . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
99,
111
]
} | {
"id": "C0001899",
"name": "glutamic pyruvic transaminase",
"pos": [
124,
153
]
} |
3 ) the second cluster had significantly high frequencies of abnormal values of systolic and diastolic blood pressure , total cholesterol , tg , fbs , uric acid , got , gpt and gamma glutamyl transferase ( ggt ) . | NA | {
"id": "C0002594",
"name": "got",
"pos": [
163,
166
]
} | {
"id": "C0001899",
"name": "gpt",
"pos": [
169,
172
]
} |
artifacts due to endotoxin were excluded by appropriate polymyxin control experiments and by comparison of effects with those of bacterial lps . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
17,
26
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
139,
142
]
} |
protection was also eliminated when the gssg reductase/gsh peroxidase system was inhibited by bischloronitrosourea ( bcnu ) , indicating that gsh transport affords protection by maintaining gsh levels in the cell . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
40,
44
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
190,
193
]
} |
thus , intact gsh is transported into isolated proximal tubule cells by a na+-dependent system , and this transported gsh can be used to supplement endogenous synthesis and gssg reduction to protect cells against oxidative injury . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
14,
17
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
173,
177
]
} |
normolipidaemic individuals homozygous for the apo e2 variant exhibit gross disturbances in the transit of b protein through the vldl-idl-ldl chain . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
129,
133
]
} | {
"id": "C0023820",
"name": "vldl",
"pos": [
129,
133
]
} |
normolipidaemic individuals homozygous for the apo e2 variant exhibit gross disturbances in the transit of b protein through the vldl-idl-ldl chain . | NA | {
"id": "C0023820",
"name": "vldl",
"pos": [
129,
133
]
} | {
"id": "C0065063",
"name": "idl",
"pos": [
134,
137
]
} |
the follow-up of 16 patients with low grade nhl showed that serum tk levels paralleled well the clinical response . | NA | {
"id": "C0079747",
"name": "low grade nhl",
"pos": [
34,
47
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
44,
47
]
} |
however , the use of an anti-asa antiserum enabled us to discriminate between asa and a comigrating contaminant isozyme , and the antigen-antibody ( ag-ab ) complex gave better evidence of the presence or absence of asa after enhancement of activity with 4-methylumbelliferyl sulphate ( 4-mus ) . | NA | {
"id": "C0003940",
"name": "asa",
"pos": [
29,
32
]
} | {
"id": "C0007804",
"name": "asa",
"pos": [
216,
219
]
} |
cultured fibroblasts from mucolipidosis iv patients accumulated phospholipids when compared to normal controls or cells from other genotypes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
9,
20
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
the culture medium was supplemented with a serum substitute devoid of lipoproteins or with one of the following lipid sources : fetal calf serum , human low-density lipoprotein ( ldl ) , or human high-density lipoprotein ( hdl ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
70,
82
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
112,
117
]
} |
group therapy was the method chosen for working with pku girls and their mothers in improving their knowledge of maternal pku and the prevention of unplanned pregnancies . | NA | {
"id": "C0031485",
"name": "pku",
"pos": [
53,
56
]
} | {
"id": "C0085547",
"name": "maternal pku",
"pos": [
113,
125
]
} |
these results suggest that hnt ( a ) potentiates the anticoagulant function of heparin , ( b ) prevents the inactivation of antiangiogenic activity of heparin by an endogenous arylsulfatase in the chorioallantoic membrane and by a commercial arylsulfatase , and ( c ) in the presence of angiostatic steroids can inhibit angiogenesis in the chick embryo without the addition of exogenous heparin . | NA | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
176,
189
]
} | {
"id": "C0007804",
"name": "a",
"pos": [
390,
391
]
} |
specific [ 3h ] r1881 binding was found in four different gubernaculum fibroblast cultures ( 9,000-42,000 sites/cell ) and mcf-7 human breast cancer cells ( 34,000 sites/cell ) which were used as controls . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
71,
81
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
170,
174
]
} |
simple esters from these highly hindered tertiary carboxylic acids , easily prepared via phase-transfer-catalyzed alkylations , also rival estradiol in uterotropic activity . | NA | {
"id": "C0014898",
"name": "esters",
"pos": [
7,
13
]
} | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
50,
66
]
} |
plasma testosterone , dihydrotestosterone and estradiol were determined in 72 healthy volunteers , divided into 36 beer and 36 wine drinkers , who consumed between 0.9-2.1 g ethanol/kg b.wt , simulating natural patterns of drinking . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
115,
119
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
174,
181
]
} |
plasma testosterone , dihydrotestosterone and estradiol were determined in 72 healthy volunteers , divided into 36 beer and 36 wine drinkers , who consumed between 0.9-2.1 g ethanol/kg b.wt , simulating natural patterns of drinking . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
127,
131
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
174,
181
]
} |
all groups exhibited both depressed and elevated testosterone levels , depending upon the time after drinking ( fast beer drinkers ) and upon the amount of alcohol ( fast wine drinkers ) . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
156,
163
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
171,
175
]
} |
the alpha 1-adrenergic receptor blocking effect of ketanserin , the blocking properties of this compound for nonspecific stimulation with angiotensin ii , and the alpha-adrenergic receptor blocking properties and the blood pressure lowering effect of phentolamine , ritanserin , and the combination of both compounds were studied in patients on cardiopulmonary bypass ( constant flow rate , mild hypothermia ) undergoing coronary artery bypass grafting . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenergic receptor",
"pos": [
4,
31
]
} | {
"id": "C0034784",
"name": "alpha-adrenergic receptor",
"pos": [
163,
188
]
} |
ventricular tachycardias that respond to procainamide may be caused by abnormal automaticity , whereas procainamide refractory tachycardias may result from triggered activity or from catecholamine-enhanced normal automaticity . | NA | {
"id": "C0042514",
"name": "ventricular tachycardias",
"pos": [
0,
24
]
} | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
127,
139
]
} |
in a double-blind randomized study , hydralazine ( n = 59 ) or the new dihydropyridine calcium antagonist felodipine ( n = 61 ) was added to previous treatment with beta-adrenoceptor blocking agents in a group of 120 patients with essential hypertension . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
71,
105
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
106,
116
]
} |
antagonism of alpha 1-adrenoceptor-mediated vascular contraction by urapidil was examined in helical strips of femoral and mesenteric arteries isolated from 13-week-old aoki spontaneously hypertensive rats ( shr ) and age-matched normotensive wistar-kyoto ( wky ) rats , since this agent has antihypertensive effect through antagonizing peripheral alpha-adrenoceptors . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenoceptor",
"pos": [
14,
34
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
348,
367
]
} |
cetamolol antagonized the beta-adrenoceptor-mediated responses induced by isoproterenol , epinephrine , norepinephrine , and salbutamol , in tissues from both the dog and guinea pig , in a concentration-dependent manner . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
104,
118
]
} |
dihydropyridine calcium antagonists such as isradipine ( pn200-110 ) selectively increase blood flow to the heart , brain , and skeletal muscle . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
0,
35
]
} | {
"id": "C0071304",
"name": "isradipine",
"pos": [
44,
54
]
} |
in the group with the intact renin-angiotensin system , isradipine ( 3 and 10 micrograms/kg i.v . ) elicited the typical systemic and regional ( measured with 15 micron tracer microspheres ) hemodynamic effects of a noncardiodepressant dihydropyridine derivative . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
56,
66
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
236,
251
]
} |
the mechanism of action has been demonstrated to result from the formation of toxic singlet oxygen and other oxygen radicals . | NA | {
"id": "C0074565",
"name": "singlet oxygen",
"pos": [
84,
98
]
} | {
"id": "C0162772",
"name": "oxygen radicals",
"pos": [
109,
124
]
} |
the suppression of platelet aggregation was not completely inhibited by alpha-2-antiplasmin . t-pa did not cause the degradation of fibrinogen or fibrin in prp , whereas uk caused the reduction of fibrinogen and fibrin , and the increase of fibrinogen- and fibrin-degradation products ( fdp ) . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
132,
138
]
} | {
"id": "C0163275",
"name": "fibrin-degradation products",
"pos": [
257,
284
]
} |
we examined responses of arterial plasma levels of the sympathetic neurotransmitter , norepinephrine ( ne ) , of the adrenomedullary hormone , epinephrine ( e ) , and of the intraneuronal ne metabolite , dihydroxyphenylglycol ( dhpg ) , after intravenous administration of the alpha-2 adrenoceptor antagonist , yohimbine , in conscious , freely-moving juvenile ( 4-week old ) or mature ( 12-week old ) rats with spontaneous hypertension ( shrs ) and their normotensive wistar-kyoto ( wky ) controls . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
89,
100
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
418,
420
]
} |
the present study was conducted to examine whether [ met5 ] -enkephalin influences the growth of transplanted neuroblastoma , and to explore the role of other opioid peptides in carcinogenesis . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
61,
71
]
} | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
159,
174
]
} |
fatty acid composition of phospholipids ( pl ) , nonesterified fatty acids ( nefa ) , triglycerides ( tg ) and cholesteryl esters ( ce ) was determined by capillary gas chromatography ( gc ) , and comparisons were made between the mi , no mi , pgi and normal groups . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
0,
10
]
} | {
"id": "C0015688",
"name": "nonesterified fatty",
"pos": [
49,
68
]
} |
the mi , no mi and pgi groups had significantly different fatty acid patterns in nefa with reduced percentages of arachidonic acid ( aa ) than controls . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
58,
68
]
} | {
"id": "C0015688",
"name": "fatty",
"pos": [
58,
63
]
} |
nefa levels , nonesterified aa levels and fatty acid patterns in this group did not differ from those patients not taking prostaglandin inhibitors . | NA | {
"id": "C0015688",
"name": "nefa",
"pos": [
0,
4
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
42,
52
]
} |
the first fraction contained serum-associated 68 kda protein , while the second fraction had two apoproteins with molecular weights of 34 kda and 10 kda . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
53,
60
]
} | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
97,
108
]
} |
this fall more likely was due to hepatic exchange of tritium for hydrogen , rather than to colonic bacterial oxidation . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
53,
60
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
65,
73
]
} |
the lactate concentration was estimated from the spectra by comparison to signals from n-acetylaspartate , creatine + phosphocreatine , and water . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
107,
115
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
118,
133
]
} |
translational initiation rates of the normally weakly expressed atp genes could be increased by up to a factor of 27 by manipulating the sequences upstream of the start codons , despite biased codon usages . | NA | {
"id": "C0242610",
"name": "start",
"pos": [
163,
168
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
193,
198
]
} |
we investigated the metabolic effects of omega-6 ( safflower oil ) and omega-3 ( fish oil ) fatty acid-enriched diets ( 65 % carbohydrate , 20 % fat ) in two patients with a syndrome of diabetes mellitus , lipodystrophy , acanthosis nigricans , chylomicronemia , and abdominal pain . | NA | {
"id": "C0015689",
"name": "omega-3",
"pos": [
71,
78
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
81,
89
]
} |
according to the carotenoid pigments contained , the mycobacterial species tested were divided into four groups : the first group of mycobacterium kansasii and m. marinum , which formed principally only beta-carotene ; | NA | {
"id": "C0007271",
"name": "carotenoid",
"pos": [
17,
27
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
203,
216
]
} |
the common carotenoid pigment throughout the genus mycobacterium was beta-carotene and the hypophasic carotenoids differed according to the species . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
69,
82
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
102,
113
]
} |
the length of lattice constants of the hexagonal lattice structures formed with the divalent cations did not relate to the quantity of the cations bound to the lps . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
84,
100
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
139,
146
]
} |
it was also demonstrated that the toxin is antigenically different from enterotoxin of c. difficile . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
34,
39
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
72,
83
]
} |
consistent with a unique role for phosphotyrosine , the other commonly occurring phosphoamino acids , o-phosphoserine and o-phosphothreonine were not effective electron transfer agents . | NA | {
"id": "C0070948",
"name": "phosphotyrosine",
"pos": [
34,
49
]
} | {
"id": "C0524823",
"name": "phosphoamino acids",
"pos": [
81,
99
]
} |
consistent with a unique role for phosphotyrosine , the other commonly occurring phosphoamino acids , o-phosphoserine and o-phosphothreonine were not effective electron transfer agents . | NA | {
"id": "C0524823",
"name": "phosphoamino acids",
"pos": [
81,
99
]
} | {
"id": "C0031721",
"name": "phosphoserine",
"pos": [
104,
117
]
} |
consistent with a unique role for phosphotyrosine , the other commonly occurring phosphoamino acids , o-phosphoserine and o-phosphothreonine were not effective electron transfer agents . | NA | {
"id": "C0524823",
"name": "phosphoamino acids",
"pos": [
81,
99
]
} | {
"id": "C0031724",
"name": "phosphothreonine",
"pos": [
124,
140
]
} |
coal-miners previously have not been shown to be at a greater risk of developing lymphoma or related malignancies , and the region in which the mine is located has lower prevalence rates of non-hodgkin 's lymphoma and hodgkin 's disease than does new south wales as a whole . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
81,
89
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
190,
213
]
} |
coal-miners previously have not been shown to be at a greater risk of developing lymphoma or related malignancies , and the region in which the mine is located has lower prevalence rates of non-hodgkin 's lymphoma and hodgkin 's disease than does new south wales as a whole . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
81,
89
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
218,
236
]
} |
it is clear that different psychosocial issues are confronted by children of different ages ( infants , young children or adolescents ) and their families . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
65,
73
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
104,
118
]
} |
a report on the national advisory committee on the acquired immunodeficiency syndrome 's workshop on human immunodeficiency virus infection and intravenous drug abuse . | NA | {
"id": "C0001175",
"name": "acquired immunodeficiency",
"pos": [
51,
76
]
} | {
"id": "C0019693",
"name": "immunodeficiency",
"pos": [
107,
123
]
} |
the experiments were performed using either a cell-free infection system with mt-4 cells , or a cell-to-cell infection system with molt-4 cells , which induces multinucleated giant cells very efficiently . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
56,
65
]
} | {
"id": "C0243026",
"name": "infection system",
"pos": [
109,
125
]
} |
the ferritin-alprenolol compound was shown to be effective in displacing specific [ 3h ] dihydroalprenolol binding from rat erythrocyte membranes with a dissociation constant ( kd ) of 25 nm . | NA | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
13,
23
]
} | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
89,
106
]
} |
type i compounds are inhibitors of adenosine kinase at 0.5 microm adenosine with ic50 values of 25 microm for 5'-n-ethylcarboxamidoadenosine and 250 microm for 5'-methylthioadenosine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
35,
44
]
} | {
"id": "C0050789",
"name": "5",
"pos": [
160,
161
]
} |
type ii compounds are inhibitors of adenosine kinase at 0.5 microm adenosine with an ic50 of 220 microm for n6-cyclohexyladenosine and 200 microm for n6-l-phenylisopropyladenosine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
36,
45
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
155,
179
]
} |
in addition , 2,6-dimenapqi reacted with gsh , both chemically and in hepatocytes , to form significant amounts of gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
41,
44
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
115,
119
]
} |
the reduction potentials of these two azo compounds were also very different ( amaranth , e = -0.620 v ; sulfonazo iii , e = -0.265 v versus normal hydrogen electrode ) . | NA | {
"id": "C0004501",
"name": "azo compounds",
"pos": [
38,
51
]
} | {
"id": "C0002406",
"name": "amaranth",
"pos": [
79,
87
]
} |
ion replacement studies reveal that the kainate channel is selective for cations over anions , but relatively non-selective among small monovalent cations . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
0,
3
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
147,
154
]
} |
ion replacement studies reveal that the kainate channel is selective for cations over anions , but relatively non-selective among small monovalent cations . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
0,
3
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
86,
92
]
} |
ion replacement studies reveal that the kainate channel is selective for cations over anions , but relatively non-selective among small monovalent cations . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
73,
80
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
136,
154
]
} |
one monoclonal antibody ( mof 0 ) is specific to the external topology of native porin in the outer membrane and three antibodies could recognize epitopes present in each conformation of subunits of trimer form . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
4,
23
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
119,
129
]
} |
three chloromethanes ( dichloromethane , chloroform and carbon tetrachloride ) and 8 chlorinated ethanes ( 1,1- and 1,2-dichloroethane , 1,1,1- and 1,1,2-trichloroethane , 1,1,1,2- and 1,1,2,2-tetrachloroethane , pentachloroethane and hexachloroethane ) were assayed in tests for the induction of mitotic segregation in aspergillus nidulans diploid strain p1 . | NA | {
"id": "C0014969",
"name": "ethanes",
"pos": [
13,
20
]
} | {
"id": "C0015082",
"name": "dichloroethane",
"pos": [
120,
134
]
} |
the uptake , metabolism and alkylating properties of the diastereomeric cholesterol epoxides were studied using chinese hamster lung fibroblasts ( v79 cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
133,
144
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
the chlorinated ethylenes 1,1-dichloroethylene ( vinylidene chloride ) , trans-1,2-dichloroethylene , trichloroethylene , and tetrachloroethylene ( perchloroethylene ) were assayed for their ability to induce mitotic gene conversion and point mutation as well as mitotic aneuploidy in diploid strains of the yeast saccharomyces cerevisiae . | NA | {
"id": "C0015096",
"name": "ethylenes",
"pos": [
16,
25
]
} | {
"id": "C0012074",
"name": "dichloroethylene",
"pos": [
83,
99
]
} |
acrolein , a short-chain aldehyde encountered as a component of tobacco smoke and as a ubiquitous environmental contaminant , was tested for its toxic and mutagenic effects toward human fibroblast cells . | NA | {
"id": "C0001204",
"name": "acrolein",
"pos": [
0,
8
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
25,
33
]
} |
the result presented suggests that the antibodies in the afb1-bsa antiserum can interact with aflatoxin b1 prior to its activation . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
39,
49
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
66,
75
]
} |
the 1358 bp py alpha t1 clone was completely sequenced and found to contain 591 nucleotides of uninterrupted coding sequence with a strong bias for at-rich codons , starting with codon 254 of a consensus alpha-tubulin sequence . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
156,
162
]
} | {
"id": "C0242610",
"name": "starting",
"pos": [
165,
173
]
} |
this alteration is consistent with the accumulation of methylated precursors of ergosterol , which affects both lipid-lipid and lipid-protein interactions in the membrane . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
112,
117
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
128,
133
]
} |
we studied separately the influence of two methods for losing fat weight on the levels of plasma lipids and lipoproteins in overweight sedentary men -- decreasing energy intake without increasing exercise ( diet ) , and increasing energy expenditure without altering energy intake ( exercise , primarily running ) -- in a one-year randomized controlled trial . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
66,
72
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
124,
134
]
} |
after dna samples were digested with the restriction endonuclease mspi ( thereby cutting the dna at specific sites ) and hybridized with a p450c11 dna probe , a unique dna fragment in the p450c11 structural gene was detected in subjects with the deficiency . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
6,
9
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
213,
214
]
} |
the main cellular population was represented by macrophages , epithelioid cells , and giant cells in the central zone , and fibroblasts in the peripheral zone . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
9,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
124,
135
]
} |
here we show how the use of mutant proteins allows the determination of the contributions of individual charges to the free energy of ion binding to proteins . | NA | {
"id": "C1564139",
"name": "mutant",
"pos": [
28,
34
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
149,
157
]
} |
in 15 undialyzed ( ud ) patients and 26 hemodialyzed ( hd ) patients , ( 1 ) basal and test meal-stimulated gastrin concentrations , ( 2 ) basal and pentagastrin-stimulated gastric acid outputs , and ( 3 ) endoscopic examinations were studied . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
108,
115
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
149,
161
]
} |
in 40 young patients with chronic renal failure ( crf ) on maintenance hemodialysis and 22 control subjects , ( 1 ) basal and test meal-stimulated gastrin concentrations , ( 2 ) basal and pentagastrin-stimulated gastric acid outputs , and ( 3 ) endoscopic examinations were studied . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
147,
154
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
188,
200
]
} |
the next distinct stage of development ( e4-e7 ) is marked in the brain by a gradual rise in glutamic acid , glutamine and aspartic acid ; | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
93,
106
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
109,
118
]
} |
studies on isolated synaptic plasma membranes ( spm ) have detected little if any heparan sulfate or other glycosaminoglycans ( gags ) , while more recent studies employing proteoglycan antibodies have localized heparan sulfate proteoglycan in presynaptic plasma membrane of intact tissue . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
82,
97
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
107,
125
]
} |
studies on isolated synaptic plasma membranes ( spm ) have detected little if any heparan sulfate or other glycosaminoglycans ( gags ) , while more recent studies employing proteoglycan antibodies have localized heparan sulfate proteoglycan in presynaptic plasma membrane of intact tissue . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
82,
97
]
} | {
"id": "C0062503",
"name": "heparan sulfate proteoglycan",
"pos": [
212,
240
]
} |
lipids were extracted from both microvascular and brain parenchymal fractions and the major phospholipid classes ( choline phosphoglyceride , ethanolamine phosphoglyceride , inositol phosphoglyceride , serine phosphoglyceride , and sphingomyelin ) separated by 2-dimensional tlc . | NA | {
"id": "C1959616",
"name": "choline",
"pos": [
115,
122
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
209,
225
]
} |
lipids were extracted from both microvascular and brain parenchymal fractions and the major phospholipid classes ( choline phosphoglyceride , ethanolamine phosphoglyceride , inositol phosphoglyceride , serine phosphoglyceride , and sphingomyelin ) separated by 2-dimensional tlc . | NA | {
"id": "C0031618",
"name": "ethanolamine phosphoglyceride",
"pos": [
142,
171
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
209,
225
]
} |
comparison of mol % determined by phosphate analysis of each phospholipid revealed significant differences in membrane composition of ethanolamine phosphoglyceride , inositol phosphoglyceride , and sphingomyelin between microvascular and parenchymal components of the central nervous system . | NA | {
"id": "C0031618",
"name": "ethanolamine",
"pos": [
134,
146
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
175,
191
]
} |
the increased methionine-enkephalin , which appears to originate from the sympatho-adrenal system or infarcted brain , may play a role in the evolution of cerebral ischaemia . | NA | {
"id": "C0751955",
"name": "infarcted brain",
"pos": [
101,
116
]
} | {
"id": "C0007785",
"name": "cerebral",
"pos": [
155,
163
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.