text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
because all but 1 of the deaths occurred among the 66 patients unconscious at the time of operation ( 27 % mortality in this subgroup ) , the authors sought differential factors between comatose and noncomatose patients at operation . | NA | {
"id": "C0041657",
"name": "unconscious",
"pos": [
63,
74
]
} | {
"id": "C0009421",
"name": "comatose",
"pos": [
202,
210
]
} |
patients comatose at operation usually evidenced a more rapid clinical deterioration ( a shorter trauma-to-operation interval ) and tended to have a large hematoma volume , a higher incidence of mixed ct density clot ( hyperacute bleeding ) , more marked shift of midline structures , more severe associated lesions , and higher postoperative icp levels . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
155,
163
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
230,
238
]
} |
torsade de pointes ( atypical ventricular tachycardia ) occurred in a 75-year-old man 1 day after blunt head injury , in association with a focal intracerebral hematoma in the left thalamic area . | NA | {
"id": "C0040479",
"name": "torsade de pointes",
"pos": [
0,
18
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
30,
53
]
} |
the neuropeptides somatostatin and neuropeptide y and the activity of glutamate decarboxylase were determined in the frontal cortex of rats subjected to experimental epilepsy . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
4,
17
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
35,
49
]
} |
separation of somatostatin-like immunoreactivity by size exclusion high-performance liquid chromatography showed a marked increase of immunoreactivity in fractions containing the somatostatin precursor ( by 200 % ) and less prominently of somatostatin-14 and somatostatin-28 ( by 60 and 80 % , respectively ) . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
239,
254
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
259,
274
]
} |
these electrophysiological results are complementary to those from pharmacological experiments and suggest that one of several physiological functions of dopamine in the nucleus accumbens is a neuromodulatory one involving presynaptic action on non-dopaminergic terminals . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
154,
162
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
249,
261
]
} |
thus the antigenic repertoire of the gbm of human fetal kidney comprises antigens of constituent molecules of the extracellular matrix and planted antigens originating from adjacent cells . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
73,
81
]
} | {
"id": "C1567994",
"name": "planted antigens",
"pos": [
139,
155
]
} |
these were consistent with mesangioproliferative glomerulonephritis in seven , focal segmental glomerulosclerosis in five , mesangiocapillary glomerulonephritis in two , membranous glomerulonephritis in one , and focal segmental hyalinosis in one patient . | NA | {
"id": "C0017658",
"name": "glomerulonephritis",
"pos": [
49,
67
]
} | {
"id": "C0017668",
"name": "focal",
"pos": [
213,
218
]
} |
in one period the patients received standard heparin , in the other org 10172 , a new low-molecular-weight-heparinoid . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
45,
52
]
} | {
"id": "C0019142",
"name": "heparinoid",
"pos": [
107,
117
]
} |
this may be related to the prolonged plasma anti-xa activity ( 30.8 h ) of this compound compared to standard heparin in dialysis patients . | NA | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
44,
51
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
110,
117
]
} |
these results suggest that presynaptic calcium channels which cause transmitter release may be n type calcium channel . | NA | {
"id": "C0006685",
"name": "calcium channels",
"pos": [
39,
55
]
} | {
"id": "C0752246",
"name": "n type",
"pos": [
95,
101
]
} |
the increase in intracellular ca2+ concentration also suppressed the currents carried by monovalent anions , such as br- , i- , no3- and hcoo- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
100,
106
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
123,
124
]
} |
minoxidil ( loniten ) , a potent predominant arteriolar vasodilator , provides prompt and effective reduction of blood pressure in many patients with severe hypertension . | NA | {
"id": "C0026196",
"name": "minoxidil",
"pos": [
0,
9
]
} | {
"id": "C2267010",
"name": "arteriolar vasodilator",
"pos": [
45,
67
]
} |
we conclude that a simplified exercise test can be both objective and sensitive in detecting eia and therefore useful in the assessment of the asthmatic patient and the effect of therapy . | NA | {
"id": "C0004099",
"name": "eia",
"pos": [
93,
96
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
143,
152
]
} |
comparison of 99tcm-labelled mdp and dmad bone scanning agents in patients with advanced breast cancer . | NA | {
"id": "C0066351",
"name": "mdp",
"pos": [
29,
32
]
} | {
"id": "C0012544",
"name": "dmad",
"pos": [
37,
41
]
} |
dimethyl-amino diphosphonate ( dmad ) has a relatively low uptake in normal bone compared with methylene diphosphonate ( mdp ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
15,
28
]
} | {
"id": "C0066351",
"name": "methylene diphosphonate",
"pos": [
95,
118
]
} |
we have compared the bone scan appearance with mdp and dmad in 11 patients with multiple bone metastases from breast cancer . | NA | {
"id": "C0066351",
"name": "mdp",
"pos": [
47,
50
]
} | {
"id": "C0012544",
"name": "dmad",
"pos": [
55,
59
]
} |
in five patients some lesions were visualized more clearly with dmad and others with mdp . | NA | {
"id": "C0012544",
"name": "dmad",
"pos": [
64,
68
]
} | {
"id": "C0066351",
"name": "mdp",
"pos": [
85,
88
]
} |
these data demonstrate that co-infusion of unlabelled moab with 111in-labelled moab could alter the organ distribution , pharmacokinetics and tumour uptake in a favourable manner , though the degree to which this occurs depends on the antibody in question . | NA | {
"id": "C0003250",
"name": "moab",
"pos": [
54,
58
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
235,
243
]
} |
prospective ophthalmic evaluation was performed in 20 individuals with hermansky-pudlak syndrome , a type of oculocutaneous albinism with an associated deficiency of dense bodies in platelets . | NA | {
"id": "C0079504",
"name": "hermansky-pudlak syndrome",
"pos": [
71,
96
]
} | {
"id": "C0078918",
"name": "oculocutaneous albinism",
"pos": [
109,
132
]
} |
recognition of this form of oculocutaneous albinism is important because of the associated pulmonary , gastrointestinal , renal , and cardiac manifestations of hermansky-pudlak syndrome . | NA | {
"id": "C0078918",
"name": "oculocutaneous albinism",
"pos": [
28,
51
]
} | {
"id": "C0079504",
"name": "hermansky-pudlak syndrome",
"pos": [
160,
185
]
} |
silicone oil was present in periretinal membranes removed several months after the intraocular silicone had been evacuated indicating that silicone within cells may persist despite the removal of silicone . | NA | {
"id": "C0037111",
"name": "silicone oil",
"pos": [
0,
12
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
196,
204
]
} |
of 105 eyes with ocular injuries involving retained intraocular foreign bodies , 63 ( 60 % ) had a final visual acuity of 20/40 or better ; | NA | {
"id": "C0015408",
"name": "of",
"pos": [
0,
2
]
} | {
"id": "C0015401",
"name": "retained intraocular foreign bodies",
"pos": [
43,
78
]
} |
acute retinal necrosis ( arn ) syndrome is a diffuse uveitis characterized by a peripheral necrotizing retinitis and retinal vasculitis . | NA | {
"id": "C0035319",
"name": "acute retinal necrosis",
"pos": [
0,
22
]
} | {
"id": "C0035333",
"name": "retinitis",
"pos": [
103,
112
]
} |
viruses can cause sialadenitis and may be associated with other diseases of salivary glands , particularly immunologically mediated and neoplastic lesions . | NA | {
"id": "C0037023",
"name": "sialadenitis",
"pos": [
18,
30
]
} | {
"id": "C0036093",
"name": "diseases of",
"pos": [
64,
75
]
} |
the discussion stresses the vital importance of awareness of the possible complications of sickle cell anemia and sickle cell trait in the safe and successful management of patients requiring dental care that includes the use of general anesthesia . | NA | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
91,
109
]
} | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
114,
131
]
} |
um-scc-38 cells were more sensitive to the photosensitizing effects of dhe than were either normal fibroblasts or malignant melanoma cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
99,
110
]
} |
a 90,000 mol . wt protein lacking the 1g7-specific epitope but immunologically related to the 90,000 mol . wt antigen of other t. cruzi isolates is present in y and cl strains . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
51,
58
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
110,
117
]
} |
similar changes were observed in peripheral blood mononuclear cells ( pbm ) and lymph node cells ( lnc ) . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
33,
67
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} |
peripheral blood mononuclear cells ( pbm ) from eight of 11 infected buffalo were found to have potent cytotoxic activity after stimulation with autologous parasitized cells for 6 days in vitro , while pbm from uninfected buffalo or pbm from infected buffalo not stimulated in vitro had no cytotoxic activity . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C1321301",
"name": "pbm",
"pos": [
233,
236
]
} |
each probe consists of one repeat unit of the major repetitive dna ( satellite dna ) of each species or intra-specific group . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
63,
66
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
69,
82
]
} |
in chickens given a primary dose of 500 infective-stage larvae followed 30 days later by a single secondary dose of 500 infective-stage larvae , the mean worm burden during the secondary infection rose to 57 nematodes on day 9 of infection and then fell rapidly to 18 nematodes on day 15 and to 2 on day 30 . | NA | {
"id": "C0018889",
"name": "worm",
"pos": [
154,
158
]
} | {
"id": "C0027583",
"name": "nematodes",
"pos": [
268,
277
]
} |
there probably has been better recognition and diagnosis of asthma by distinguishing it from bronchitis , recurrent croup , and bronchiolitis in children . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
93,
103
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
128,
141
]
} |
whereas one patient presents a syndromic association of bone dysplasia and intrauterine dwarfism two other patients can not be appropriately evaluated due to lack of basic clinical and pathologic data . | NA | {
"id": "C0005941",
"name": "bone dysplasia",
"pos": [
56,
70
]
} | {
"id": "C0013336",
"name": "dwarfism",
"pos": [
88,
96
]
} |
striking similarities with established genetic disorders of collagen ( like the osteogenesis imperfecta group and the ehlers-danlos syndrome ) suggest , however , that the ops could be a primary collagen disorder . | NA | {
"id": "C0009326",
"name": "disorders",
"pos": [
47,
56
]
} | {
"id": "C0029434",
"name": "osteogenesis imperfecta",
"pos": [
80,
103
]
} |
striking similarities with established genetic disorders of collagen ( like the osteogenesis imperfecta group and the ehlers-danlos syndrome ) suggest , however , that the ops could be a primary collagen disorder . | NA | {
"id": "C0009326",
"name": "disorders",
"pos": [
47,
56
]
} | {
"id": "C0013720",
"name": "ehlers-danlos syndrome",
"pos": [
118,
140
]
} |
we suggest that the morphologic phenotype found in patients with pseudopseudohypoparathyroidism , also known as albright 's hereditary osteodystrophy , has an associated risk for spinal cord compression due to congenital vertebral anomalies . | NA | {
"id": "C0033835",
"name": "pseudopseudohypoparathyroidism",
"pos": [
65,
95
]
} | {
"id": "C0033806",
"name": "albright 's",
"pos": [
112,
123
]
} |
children with hemophilia-associated aids were older than other children with aids ( medians 13 and 1 years , respectively ) and less frequently had lymphocytic interstitial pneumonitis ( 5 % v 48 % ) but had similar incidences of pneumocystis carinii pneumonia ( 51 % v 53 % ) and similar case to fatality ratios ( 59 % v 61 % ) . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
0,
8
]
} | {
"id": "C1455726",
"name": "older",
"pos": [
46,
51
]
} |
it is concluded that , although some of the clinical manifestations of aids ( eg , lymphocytic interstitial pneumonitis ) occurring or not occurring in older children infected through blood factor products differ from those of other children with aids , disease outcome to date is equally poor . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
152,
166
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
233,
241
]
} |
hypoxanthine levels in vitreous humor from 32 infants who died of sudden infant death syndrome ( sids ) were determined and compared with levels found in eight children who died of trauma , drowning , or hanging and with levels from seven neonates dying suddenly without long-standing antemortem hypoxia . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
58,
62
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
190,
198
]
} |
the hospital records of 951 children from a previously established birth cohort for which behavioral and extensive background information was available were checked for 3 years following the fifth birthday of the youngest child . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
28,
36
]
} | {
"id": "C0728836",
"name": "of",
"pos": [
206,
208
]
} |
the channel also conducts ca2+ , since inward currents were observed using pipette solutions in which ca2+ ions were the only inorganic cations . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
88,
92
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
136,
143
]
} |
gcd1 encodes a protein of 511 amino acids whose predicted sequence does not exhibit significant homology to any other known proteins and appears too large to be a ribosomal protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
124,
132
]
} | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
163,
180
]
} |
we previously demonstrated a modest but significant protective effect of inhaled gallopamil ( d600 ) , the methoxy derivative of verapamil , against methacholine-induced bronchoconstriction ; | NA | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
81,
91
]
} | {
"id": "C0042523",
"name": "verapamil",
"pos": [
129,
138
]
} |
in other studies , contact sensitization reactions to the structurally related hapten , trinitrochlorobenzene ( tncb ) , have been used to test the immunogenic properties of haptenated subpopulations of epidermal cells . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
79,
85
]
} | {
"id": "C0031891",
"name": "trinitrochlorobenzene",
"pos": [
88,
109
]
} |
we conclude that low-dose uvb radiation interrupts the induction of contact hypersensitivity to tncb , leading to hapten-specific nonresponsiveness rather than hypersensitivity , and that this capacity to prevent successful immunization with tncb is limited to the site of irradiation . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
114,
120
]
} | {
"id": "C0031891",
"name": "tncb",
"pos": [
242,
246
]
} |
fractures were randomly selected with clear history of trauma , which were matched to the patients with no trauma for age , sex , and type of fracture as a control group . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
0,
9
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} |
the multiplicity of problems associated with spina bifida and charge syndrome illustrate a management approach for any child with multiple congenital anomalies . | NA | {
"id": "C0265354",
"name": "charge syndrome",
"pos": [
62,
77
]
} | {
"id": "C0000772",
"name": "multiple congenital",
"pos": [
130,
149
]
} |
the autoimmune diseases , juvenile rheumatoid arthritis and systemic lupus erythematosus , are two of the more common acquired chronic diseases of childhood . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
4,
23
]
} | {
"id": "C0024141",
"name": "systemic lupus",
"pos": [
60,
74
]
} |
increases in serum bilirubin are typical with jaundice caused by clostridial myelonecrosis , severe bacterial sepsis , and relapsing fever ( borreliosis ) . | NA | {
"id": "C0035021",
"name": "relapsing fever",
"pos": [
123,
138
]
} | {
"id": "C0006035",
"name": "borreliosis",
"pos": [
141,
152
]
} |
the antibodies used in the immunohistochemical analyses were monoclonal antibodies ( mabs ) 1-7-1 and 2-66-3 , prepared against the 3-methylcholanthrene-induced and phenobarbital-induced rat liver p-450 , respectively . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
61,
82
]
} |
placental cell lines derived from midgestation placentae of outbred mice and rats were evaluated for the expression of the extracellular matrix protein laminin . | NA | {
"id": "C0079323",
"name": "extracellular matrix protein",
"pos": [
123,
151
]
} | {
"id": "C0022984",
"name": "laminin",
"pos": [
152,
159
]
} |
using radioimmunoassay , we tested serum elastase 1 ( e1 ) , an enzyme secreted only from the pancreas , in 200 subjects as follows : 39 healthy subjects as controls , 56 patients with diseases of the digestive tract , 66 patients with hepatobiliary diseases , and 39 patients with pancreatic diseases . | NA | {
"id": "C0012242",
"name": "diseases of the digestive",
"pos": [
185,
210
]
} | {
"id": "C0030286",
"name": "pancreatic diseases",
"pos": [
282,
301
]
} |
molindone , a novel neuroleptic of the indoleamine class , has been shown in basic paradigms to discriminate between brain dopaminergic systems by virtue of its ability to preferentially inhibit dopamine autoreceptors ( dars ) . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
123,
135
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
195,
203
]
} |
competition experiments using lactosylceramide , ganglioside gm3 and ganglioside gd3 as substrates , as well as mutual inhibitors for ganglioside n-acetylgalactosaminyltransferase , in golgi vesicles derived from rat liver suggested that n-acetylgalactosamine transfer to these three respective compounds , leading to gangliosides ga2 , gm2 , and gd2 , respectively , is catalyzed by one enzyme . | NA | {
"id": "C0016897",
"name": "ganglioside gm3",
"pos": [
49,
64
]
} | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
318,
329
]
} |
uroporphyrinogen iii synthase [ uro-synthase ; hydroxymethylbilane hydro-lyase ( cyclizing ) , ec 4.2.1.75 ] , the fourth enzyme in the heme biosynthetic pathway , is responsible for conversion of the linear tetrapyrrole , hydroxymethylbilane , to the cyclic tetrapyrrole , uroporphyrinogen iii . | NA | {
"id": "C0042089",
"name": "uroporphyrinogen iii synthase",
"pos": [
0,
29
]
} | {
"id": "C0020239",
"name": "hydro-lyase",
"pos": [
67,
78
]
} |
the structural features of the eta chain and the domain organization of tyrosine and tryptophan hydroxylases suggest that the 14-3-3 protein binds to the regulatory domain of the phosphorylated hydroxylases through its acidic carboxyl-terminal region and activates the hydroxylases by inducing an active conformation . | NA | {
"id": "C0041252",
"name": "tryptophan hydroxylases",
"pos": [
85,
108
]
} | {
"id": "C0020364",
"name": "hydroxylases",
"pos": [
269,
281
]
} |
retroviral proteins , including those from the human immunodeficiency virus ( hiv ) , are synthesized as polyprotein precursors that require proteolytic cleavage to yield the mature viral proteins . | NA | {
"id": "C0035367",
"name": "retroviral proteins",
"pos": [
0,
19
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
182,
196
]
} |
based on these results and other recent reports , we propose that the extracellular phosphocreatine , atp , and creatine are involved in sperm metabolism . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
84,
99
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
112,
120
]
} |
beta-amyloid precursor protein of alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues . | NA | {
"id": "C0085151",
"name": "beta-amyloid precursor protein",
"pos": [
0,
30
]
} | {
"id": "C0025252",
"name": "membrane-associated proteins",
"pos": [
85,
113
]
} |
monocytes initiate coagulation through regulated surface expression of tissue factor and local assembly of a proteolytic enzymatic complex formed by tissue factor and factor vii/activated factor vii . | NA | {
"id": "C0005789",
"name": "coagulation",
"pos": [
19,
30
]
} | {
"id": "C0040048",
"name": "tissue",
"pos": [
149,
155
]
} |
the tissue content and specific activity of creatine and pcr were determined at the end of each period . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
44,
52
]
} | {
"id": "C0031634",
"name": "pcr",
"pos": [
57,
60
]
} |
the higher specific activity found for tissue pcr ( 1.87 times ) than creatine , independent of the percentage of total intracellular creatine that was present as free creatine , provides evidence for the existence of two separate pools of free creatine . | NA | {
"id": "C0031634",
"name": "pcr",
"pos": [
46,
49
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
245,
253
]
} |
about 36 % of the total creatine is bound to unknown intracellular components and the rest exists as pcr . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
24,
32
]
} | {
"id": "C0031634",
"name": "pcr",
"pos": [
101,
104
]
} |
the protein fraction forms a joint molecule between a circular single-strand dna and a homologous linear duplex dna that is resolved from the substrates by agarose gel electrophoresis . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
in the electron microscope , joint molecules are seen to consist of a circular single-strand dna molecule attached to only one end of a linear duplex dna molecule ; | NA | {
"id": "C0012935",
"name": "single-strand dna",
"pos": [
79,
96
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
150,
153
]
} |
dna polymerase iii from saccharomyces cerevisiae is analogous to the mammalian dna polymerase delta by several criteria , including an increased synthetic activity on poly ( da ) .oligo ( dt ) ( 40:1 nucleotide ratio ) in the presence of calf thymus proliferating-cell nuclear antigen ( pcna ) , or cyclin . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
269,
284
]
} | {
"id": "C0072108",
"name": "cyclin",
"pos": [
299,
305
]
} |
a 537-base cdna encoding a portion of saccharomyces cerevisiae dihydrolipoamide acetyltransferase ( acetyl-coa : dihydrolipoamide s-acetyltransferase , ec 2.3.1.12 ) was isolated from a lambda gt11 yeast cdna library by immunoscreening . | NA | {
"id": "C0058087",
"name": "dihydrolipoamide",
"pos": [
63,
79
]
} | {
"id": "C0001068",
"name": "acetyltransferase",
"pos": [
132,
149
]
} |
analysis of the deduced amino acid sequence of the dihydrolipoamide acetyltransferase revealed a multidomain structure similar to those reported for the corresponding acetyltransferases from escherichia coli and rat liver , and extensive sequence similarity among the three enzymes . | NA | {
"id": "C0058087",
"name": "dihydrolipoamide acetyltransferase",
"pos": [
51,
85
]
} | {
"id": "C0001068",
"name": "acetyltransferases",
"pos": [
167,
185
]
} |
a particular advantage of targeting to surface-bound monoclonal antibodies is that all other available effector systems may also attack the same antibody-coated target cell . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
53,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
145,
153
]
} |
plaque-inhibition assays confirmed the viral specificity of the antibodies , and when one antibody , af3 , was used as a probe in immunoblots of cell membrane preparations , it detected a 100-kda band in only those cell lines and tissues permissive for poliovirus infection . | NA | {
"id": "C0003253",
"name": "viral",
"pos": [
39,
44
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
90,
98
]
} |
hypertension was induced in groups of rats by implantation of deoxycorticosterone acetate in conjunction with 1 % salt in the drinking water ( deoxycorticosterone/salt ) . | NA | {
"id": "C0813203",
"name": "deoxycorticosterone acetate",
"pos": [
62,
89
]
} | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
143,
162
]
} |
in striatal aggregates cultured over a 3-week period , the relative levels of arpp-16 , arpp-21 , and synapsin i/protein iiia ( synaptic vesicle-associated phosphoproteins closely related to each other and treated as a single entity in the present study ) increased with time , whereas the level of arpp-19 decreased . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
113,
120
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
156,
171
]
} |
the role of guanine nucleotide-binding proteins ( g proteins ) in the camp-dependent action of serotonin ( 5-ht ) and the antagonistic action of the neuropeptide phe-met-arg-phe-nh2 ( fmrf-amide ) , mediated by the lipoxygenase metabolites of arachidonic acid , was investigated in aplysia sensory neurons . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
149,
161
]
} | {
"id": "C0060608",
"name": "fmrf-amide",
"pos": [
184,
194
]
} |
these results demonstrate that igf-i mediates the stimulatory effect of growth hormone on erythropoiesis in vivo and thus further support the somatomedin concept . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
31,
36
]
} | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
142,
153
]
} |
following chronic administration ( 10 or 20 days ) of diazepam ( 5 mg/kg/day , subcutaneous pellets ) or ro 15-1788 ( 5 mg/kg/day , intraperitoneally ) , adenosine and benzodiazepine receptors in different rat brain areas were assessed by radioligand binding studies using [ 3h ] r-pia for a1 receptors , [ 3h ] neca and [ 3h ] r-pia for a2 receptors and [ 3h ] fnz for benzodiazepine receptors . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
154,
163
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
312,
316
]
} |
in the present work the effects of a stable analog of adenosine ( n-6-l-phenylisopropyladenosine , l-pia ) have been investigated against the epileptic focus induced by intracortical injection of penicillin . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
54,
63
]
} | {
"id": "C0031484",
"name": "l-pia",
"pos": [
99,
104
]
} |
2 ) activation of gaba-b receptors with gaba ( 10 ( -6 ) -10 ( -3 ) m ) or ( - ) -baclofen ( 10 ( -6 ) -10 ( -3 ) m ) caused a dose-related inhibition of twitch response that was about 80 % lower in preparations from morphine-tolerant animals than in controls . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
18,
22
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
82,
90
]
} |
intracerebroventricular pretreatment with sarcosine1 , alanine8-angiotensin ii , 1 microgram/rat , completely suppresses the effect of eledoisin , suggesting that it is mediated by angiotensin release and angiotensin ii receptor activation . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
64,
78
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
205,
216
]
} |
stability testing of derivatives of brenzcatechine [ norepinephrine hydrogentartrate ( 1 ) , epinephrine hydrogentartrate ( 2 ) , isoprenaline sulfate ( 3 ) ] was carried out by stress investigation storing them at different temperatures . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
53,
67
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
to explore changes in immune cell status with changes in the hypothalamic-pituitary ( hp ) axis in 20 patients with major depression as compared with 20 age- , sex- , and race-matched control subjects , we examined peripheral blood mononuclear cells ( pbmc ) for total t-cells ( t3 ) , total b-cells ( b1 ) , two t-cell subsets ( t4 and t8 ) , and natural killer cells ( nkh1 ) , and we measured the plasma level of cortisol , adrenocorticotropic hormone ( acth ) , growth hormone ( gh ) , and prolactin ( prl ) . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
29,
33
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
215,
249
]
} |
nidr 's 40th anniversary in 1988 recognizes its continuing commitment to oral disease prevention and health research , and to achieving the goal of people maintaining their natural dentition for a lifetime . | NA | {
"id": "C0026636",
"name": "oral disease",
"pos": [
73,
85
]
} | {
"id": "C0026644",
"name": "natural dentition",
"pos": [
173,
190
]
} |
mctd is characterized by clinical features that overlap those of several of the classic rheumatic and connective tissue disorders . | NA | {
"id": "C0026272",
"name": "mctd",
"pos": [
0,
4
]
} | {
"id": "C0009782",
"name": "connective tissue disorders",
"pos": [
102,
129
]
} |
perfusion of the endogenous neuropeptide , fmrfamide , through the isolated gill of aplysia facilitated the amplitude of the gill withdrawal reflex ( gwr ) evoked by tactile stimulation of the gill . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
28,
40
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
43,
52
]
} |
the chondrocyte is now recognized as the probable cellular source of intra-articular extracellular ppi ( see figs . 3 and 4 ) . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
4,
15
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
90,
98
]
} |
using 31p-mr spectroscopy spectra with good signal-to-noise ratio were obtained in five different types of tumours ( ewing 's sarcoma , osteosarcoma , malignant melanoma , metastases from a squamous cell carcinoma , parotid adenoma ) . | NA | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
117,
133
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
136,
148
]
} |
[ the acquired hyperostosis syndrome . synthesis of 13 personal observations of sternocostoclavicular hyperostosis and 300 cases from the literature . 1 ] . | NA | {
"id": "C0020492",
"name": "hyperostosis",
"pos": [
15,
27
]
} | {
"id": "C0020499",
"name": "hyperostosis",
"pos": [
102,
114
]
} |
the function of contractile system of microtubules on the mechanism of mast cell exocytosis by using colchicine , a depolymerizing alkaloid of the microtubular system , has been studied . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
101,
111
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
131,
139
]
} |
ansamycin lm 427 ( or rifabutine ) is a spiropiperidyl-rifamycin which has been proposed as a treatment for tuberculosis and mycobacterial infections resistant to rifampicin . | NA | {
"id": "C0140575",
"name": "rifabutine",
"pos": [
22,
32
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
55,
64
]
} |
ansamycin lm 427 ( or rifabutine ) is a spiropiperidyl-rifamycin which has been proposed as a treatment for tuberculosis and mycobacterial infections resistant to rifampicin . | NA | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
55,
64
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
163,
173
]
} |
the nutritional status of a tumor patient can be negatively influenced by the local and systemic effects of the malignant tumor ( tumor cachexia , anorexia , difficult oral food intake ) , by the effects of the various antitumoral therapy modalities ( surgery , radiotherapy , chemotherapy ) , and by the complications associated with such modalities ( anorexia , nausea , vomiting , mucositis , xerostomia , alterations of the smell and taste sensations , odynophagia , dysphagia , maldigestion , malabsorption , diarrhea , steatorrhea , conditioned aversions , radiogenic late effects ) , as well as by the psychological reactions of the patient to the real or feared existence of his tumor . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
498,
511
]
} | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
525,
536
]
} |
neurosurgery for cancer pain may always be considered when the pain no longer responds to conservative treatment methods or only at the cost of undesirable side-effects . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
17,
28
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
63,
67
]
} |
during infusion of clinical doses of norepinephrine , epinephrine and dopamine in dogs , the plasma level of catecholamine and the plasma flow were measured simultaneously . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
54,
65
]
} |
the calculated contribution values indicate that hepatic circulation clears 15.9 % of norepinephrine , 24.2 % of epinephrine and 9.0 % of dopamine administered exogenously . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
86,
100
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
113,
124
]
} |
the expression of carcinoembryonic antigen ( cea ) and related antigens in 40 formalin-fixed paraffin embedded tissues of 4 histological types of lung carcinomas was examined immunohistochemically using five monoclonal antibodies ( moabs ) which distinguished different epitopes on cea , and the correlation with serum-cea ( s-cea ) level and tissue-cea ( t-cea ) was also investigated . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
63,
71
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
270,
278
]
} |
susceptibilities of gram-negative bacterial strains isolated at the university hospital in 1987 to six beta-lactam antibiotics ( azthreonam cefmetazole , ceftizoxime , latamoxef , aminobenzyl-penicillin and piperacillin ) and two aminoglycoside antibiotics ( gentamicin and amikacin ) were examined by agar dilution and the agar diffusion method . | NA | {
"id": "C0002680",
"name": "aminobenzyl-penicillin",
"pos": [
180,
202
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
207,
219
]
} |
most of the strains belonging to escherichia coli , klebsiella oxytoca , klebsiella pneumoniae and proteus mirabilis were sensitive to the beta-lactam antibiotics except aminobenzyl-penicillin and piperacillin . | NA | {
"id": "C0002680",
"name": "aminobenzyl-penicillin",
"pos": [
170,
192
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
197,
209
]
} |
in previous studies , aminoglycosides ( ag ) as gentamicin ( g ) , dibekacin ( d ) , tobramycin ( t ) , netilmicin ( n ) and sysomicin ( s ) were proved to induce ultrastructural alterations in the liver of experimental animals . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
22,
37
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
48,
58
]
} |
among all of these proteins , c3 fragment of the complement system and haptoglobin , acute phase reactants proteins , are considered important mediators of the inflammatory response although their specific behaviour is not completely understood . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
71,
82
]
} | {
"id": "C0001347",
"name": "acute phase",
"pos": [
85,
96
]
} |
although these findings do not entirely exclude a role for immune complexes formed at the onset in the circulation or tissues , it is concluded from this and other evidence that circulating complexes are not commonly responsible for the persistence of syndromes in this disease . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
252,
261
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
270,
277
]
} |
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