text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these gammaglobulin obtained by acidic elution from washed placentas ( pegg ) were compared to plasmatic immunoglobulin ( ig ) for their ability to inhibit mixed lymphocyte reaction ( mlr ) , for their content of antibodies ( ab ) directed against human tissues or bacteria and viruses . | NA | {
"id": "C0017007",
"name": "gammaglobulin",
"pos": [
6,
19
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
105,
119
]
} |
clinical and experimental data indicate that the concentration of gastrin-i and somatostatin binding sites in human and rat gastric and duodenal mucosa may be changed in several pathologic conditions , including human peptic ulcer and cancer diseases . | NA | {
"id": "C0030660",
"name": "pathologic conditions",
"pos": [
178,
199
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
242,
250
]
} |
besides this predominant role of especially serine proteases a direct , non-zymosan-dependent stimulatory effect of cartilage matrix on pmn to release elastase into the incubation medium was detected . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
44,
60
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
151,
159
]
} |
a prison inmate was referred to us for diagnostic procedures and therapy due to a combination of pneumomediastinum with emphysema of neck and face . | NA | {
"id": "C0025062",
"name": "pneumomediastinum",
"pos": [
97,
114
]
} | {
"id": "C0013990",
"name": "emphysema",
"pos": [
120,
129
]
} |
isolated mesenteric fibrosis is a rare variety of systemic idiopathic fibrosis , a disease entity including fibrosis of the retroperitoneum and other sites . | NA | {
"id": "C0016059",
"name": "fibrosis",
"pos": [
20,
28
]
} | {
"id": "C0035357",
"name": "fibrosis",
"pos": [
108,
116
]
} |
of the 15 prognostic factors considered , initial fev1 , body-weight , smoking behavior , diagnosis of bronchial asthma or emphysema , finding of p pulmonale and reversibility of bronchodilation had a significant influence on survival . | NA | {
"id": "C0005910",
"name": "body-weight",
"pos": [
57,
68
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
135,
142
]
} |
although written evidence of fits goes back nearly 3000 years , epilepsy is considerably older in phylogenetic terms . | NA | {
"id": "C0036572",
"name": "fits",
"pos": [
29,
33
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
64,
72
]
} |
the mechanism by which the scanning ribosome recognizes the first aug codon nearest the 5 ' end of eukaryotic messenger rna has not been established . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
70,
75
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
110,
123
]
} |
thus , the definition of epitopes on m. leprae antigens that are recognized by t cells from different individuals might result in the development of an effective vaccine against leprosy . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
25,
33
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
47,
55
]
} |
expression of a complementary dna ( cdna ) encoding the mouse myod1 protein in a variety of fibroblast and adipoblast cell lines converts them to myogenic cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
92,
102
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
155,
160
]
} |
other known endothelial cell growth promoting factors , such as acidic and basic fibroblast growth factors and epidermal growth factor , did not support the long-term growth of the aids-ks cells . | NA | {
"id": "C0016026",
"name": "endothelial cell growth",
"pos": [
12,
35
]
} | {
"id": "C0380603",
"name": "basic fibroblast growth factors",
"pos": [
75,
106
]
} |
the alanine detection limit corresponds to fewer than 6000 molecules injected onto the column and represents an improvement of four orders of magnitude in the state of the art for fluorescent detection of amino acids and an improvement of six orders of magnitude in the state of the art for the detection limit for isothiocyanate derivatives of amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
4,
11
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
345,
356
]
} |
since monoclonal antibodies to cd3 ( anti-cd3 ) can activate t cells in vitro , an attempt was made to determine if tumor immunity could be achieved by the administration of anti-cd3 in vivo . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
6,
27
]
} | {
"id": "C0003241",
"name": "anti-cd3",
"pos": [
174,
182
]
} |
it has been demonstrated that the surface of large vldl sf 100-400 can bind both prothrombin and factor x ( xa ) and that on vldl factor xa can convert prothrombin to thrombin , which degrades apo b and apo e . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
97,
105
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
130,
139
]
} |
recent studies have shown that apo ( a ) has a striking amino acid sequence homology with plasminogen , a serine protease zymogen that following activation to plasmin enters the fibrinolytic system . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
106,
121
]
} | {
"id": "C0016016",
"name": "plasmin",
"pos": [
159,
166
]
} |
whereas the mechanism of the hypolipidemic action of the omega-6-rich vegetable oils containing linoleic acid , such as corn or safflower oil , still remains obscure , the mechanism of action of the omega-3 fatty acids in fish oil has been well documented within a few years of their use as hypolipidemic agents . | NA | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
199,
218
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
222,
230
]
} |
coupled with the known antithrombotic actions of omega-3 fatty acids from fish oil because of changes in prostaglandin secretion and platelet function , these hypolipidemic effects would appear to have an important potential role in the control of coronary heart disease and other atherosclerotic disorders . | NA | {
"id": "C0015689",
"name": "omega-3 fatty",
"pos": [
49,
62
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
74,
82
]
} |
our understanding of the effects of fish oil and the omega-3 fatty acids on platelet and vascular composition and function has increased substantially in the last decade . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
36,
44
]
} | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
53,
72
]
} |
we identified 109 patients in whom a discharge diagnosis of intestinal obstruction due to volvulus was made from 1966 to 1985 . | NA | {
"id": "C0021843",
"name": "of intestinal obstruction",
"pos": [
57,
82
]
} | {
"id": "C0042961",
"name": "volvulus",
"pos": [
90,
98
]
} |
tuberculosis remains a significant disease in developing countries and in the united states , and tuberculoma is a well known presentation of childhood tuberculosis . | NA | {
"id": "C0041295",
"name": "tuberculoma",
"pos": [
98,
109
]
} | {
"id": "C0041296",
"name": "tuberculosis",
"pos": [
152,
164
]
} |
symptoms were related to complications , including obstruction of the common bile duct , mucosal ulcer with hemorrhage , intussusception , and intestinal obstruction , but not to pathologic conditions of the pancreas itself , such as pancreatitis or pancreatic cyst or neoplasm . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
121,
136
]
} | {
"id": "C0021843",
"name": "intestinal obstruction",
"pos": [
143,
165
]
} |
symptoms were related to complications , including obstruction of the common bile duct , mucosal ulcer with hemorrhage , intussusception , and intestinal obstruction , but not to pathologic conditions of the pancreas itself , such as pancreatitis or pancreatic cyst or neoplasm . | NA | {
"id": "C0030286",
"name": "conditions of the pancreas",
"pos": [
190,
216
]
} | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
234,
246
]
} |
diagnostic cervical medial branch blocks and zygapophysial joint blocks were used to test the hypothesis that the cervical zygapophyseal joints can be the source of pain in patients with idiopathic neck pain . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
165,
169
]
} | {
"id": "C0007859",
"name": "in",
"pos": [
205,
207
]
} |
the surgical management of patients with adrenal disease depends on the functional nature of the endocrinopathy . | NA | {
"id": "C0001621",
"name": "adrenal disease",
"pos": [
41,
56
]
} | {
"id": "C0014130",
"name": "endocrinopathy",
"pos": [
97,
111
]
} |
several follow-up strategies used in recent studies were evaluated for sensitivity and specificity in identifying the patient who had postoperative infarctions or ischemia . | NA | {
"id": "C0021308",
"name": "infarctions",
"pos": [
148,
159
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
163,
171
]
} |
the problem of hypergastrinemia in patients with the syndrome of multiple endocrine neoplasia ( men type 1 ) has become increasingly controversial since the introduction of the antisecretory h2 antagonists for the treatment of the zollinger-ellison syndrome ( zes ) . | NA | {
"id": "C0027662",
"name": "syndrome",
"pos": [
53,
61
]
} | {
"id": "C0025267",
"name": "men type 1",
"pos": [
96,
106
]
} |
evaluation of lupus anticoagulants : antiphospholipid antibodies , endothelium associated immunoglobulin , endothelial prostacyclin secretion , and antigenic protein s levels . | NA | {
"id": "C0085240",
"name": "lupus anticoagulants",
"pos": [
14,
34
]
} | {
"id": "C0162595",
"name": "antiphospholipid antibodies",
"pos": [
37,
64
]
} |
fifteen of nineteen la plasmas contained apa , with five exhibiting igg only , two exhibiting igm , and eight plasmas containing both igg and igm . | NA | {
"id": "C0085240",
"name": "la",
"pos": [
20,
22
]
} | {
"id": "C0162595",
"name": "apa",
"pos": [
41,
44
]
} |
during 10 days of standard heparin or low molecular weight heparin treatment , two different patterns of fdp evolution could be identified in these patients , independent of the type of heparin used . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
38,
66
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
186,
193
]
} |
it was found that phospholipids in the vhdl fraction make a 20.2 +/- 7.3 % ( mean +/- s.d . ) part of the total hdl-phospholipids . | NA | {
"id": "C0771648",
"name": "phospholipids",
"pos": [
18,
31
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
116,
129
]
} |
the dose response ec50 values for the induction of aryl hydrocarbon hydroxylase ( ahh ) and ethoxyresorufin o-deethylase ( erod ) by the flame retardant pyrolysates was determined in rat hepatoma h-4-ii e cells and compared to the relative induction activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin ( tcdd ) and the concentrations of `` '' 2,3,7,8-tcdd equivalents '' '' were calculated . | NA | {
"id": "C0003927",
"name": "aryl",
"pos": [
51,
55
]
} | {
"id": "C0059735",
"name": "ethoxyresorufin o-deethylase",
"pos": [
92,
120
]
} |
the in vivo responses which were measured included hepatic microsomal ahh and erod induction , body weight loss and thymic atrophy . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
70,
73
]
} | {
"id": "C0059735",
"name": "erod",
"pos": [
78,
82
]
} |
intracerebroventricular administration of the selective mu ( mu ) opioid receptor agonist , ( d-ala2 , n-mephe4 , gly-ol5 ) enkephalin ( dago ; 25-50 micrograms ) , or the selective delta ( delta ) opioid agonist , [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ; 3-50 micrograms ) , like morphine , produced significant decreases in hepatic glutathione 3 h after administration . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
124,
134
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
137,
141
]
} |
intracerebroventricular administration of the selective mu ( mu ) opioid receptor agonist , ( d-ala2 , n-mephe4 , gly-ol5 ) enkephalin ( dago ; 25-50 micrograms ) , or the selective delta ( delta ) opioid agonist , [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ; 3-50 micrograms ) , like morphine , produced significant decreases in hepatic glutathione 3 h after administration . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
124,
134
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
248,
253
]
} |
adult female swiss webster and b6c3f1 mice received distilled water only or water containing 0.1 , 1.0 , 10 , 100 or 1000 ppb of aldicarb daily for 34 days . | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
52,
67
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
76,
81
]
} |
ninety-five venom samples from eight snake genera ( agkistrodon , bitis , bothrops , calloselasma , crotalus , sistrurus , naja and vipera ) including venoms of crotalus species of different geographical origin were assayed using immunodiffusion or an elisa for the presence of the small basic protein , myotoxin alpha , known to cause muscle necrosis . | NA | {
"id": "C0037380",
"name": "venom",
"pos": [
12,
17
]
} | {
"id": "C0042479",
"name": "venoms",
"pos": [
151,
157
]
} |
lead concentration in blood and testes and the levels of testosterone and delta 4-androgen biosynthesis pathway precursors ( 4-androstenedione , 17-hydroxyprogesterone , and progesterone ) were measured in animals which were exposed to lead acetate in the drinking water ( 366 mg/l , 0.97 +/- 0.12 mg lead/animal/day ) during 6 months . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
145,
167
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
174,
186
]
} |
ethanol at 0.07-0.08 % blood alcohol concentration ( bac ) caused significant decrements on both the auditory tone and tracking tests in the dual task . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
0,
7
]
} | {
"id": "C0684262",
"name": "blood",
"pos": [
23,
28
]
} |
to achieve an intense blue in the second stain for some antigens , e.g. , cd4 , either the mab concentration had to be increased or two different mabs recognizing differing epitopes of the same antigen , e.g. , t1 and ucht2 for cd5 , were applied . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
173,
181
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
194,
201
]
} |
optimal procedures for minimizing the chance of negative staining of chat-containing axon terminals consisted of perfusion with a mixture of 4 % paraformaldehyde and 0.2 % glutaraldehyde for 3 min followed by a fixative containing only 4 % paraformaldehyde for 10 min , and reaction with the anti-chat antibody for 2 days at 37 c . | NA | {
"id": "C0008407",
"name": "chat",
"pos": [
69,
73
]
} | {
"id": "C0001068",
"name": "anti-chat",
"pos": [
292,
301
]
} |
the canadian american ticlopidine study is a randomized , placebo-controlled , double-blind , multicenter study to assess the efficacy and safety of ticlopidine hydrochloride in patients who have suffered a thromboembolic stroke no less than 1 week and no more than 4 months before entry into the study . | NA | {
"id": "C0040207",
"name": "ticlopidine",
"pos": [
22,
33
]
} | {
"id": "C0000598",
"name": "ticlopidine",
"pos": [
149,
160
]
} |
the presence of ampicillin , fusidic acid , benzylpenicillin , and gentamicin in serum appeared not to interfere with the method . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
16,
26
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
44,
60
]
} |
this new technique makes use of low-density polypropylene beads ( density : 0.91 ) coated with a monoclonal antibody anti-calla ( antibody alb2 ) . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
97,
116
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
130,
138
]
} |
it is likely that histamine under pathological conditions such as renal colic and inflammatory reactions is released from mast cells within the ureter and induces a state of forceful contractions and pain fibre stimulation . | NA | {
"id": "C0030660",
"name": "pathological conditions",
"pos": [
34,
57
]
} | {
"id": "C0021368",
"name": "inflammatory",
"pos": [
82,
94
]
} |
in patients with chronic urinary obstruction the excretion of prostaglandin e ( 2 ) ( pge2 ) and thromboxane b ( 2 ) ( txb2 ) was measured . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
62,
77
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
86,
90
]
} |
in 40 of more than 800 patients evaluated for stress incontinence , type 3 urinary incontinence was diagnosed by clinical , urodynamic , and radiographic examination . | NA | {
"id": "C0042025",
"name": "stress",
"pos": [
46,
52
]
} | {
"id": "C0042024",
"name": "urinary incontinence",
"pos": [
75,
95
]
} |
the effect of starvation on blood glucose , muscle glycogen and liver glycogen concentration was measured in a group of newborn piglets . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
51,
59
]
} | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
64,
78
]
} |
the interrelated changes in liver glycogen , muscle glycogen , and plasmaglucose concentrations found in this study correspond with those reported elsewhere . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
28,
42
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
52,
60
]
} |
east coast fever ( theileria parva infection ) is an important parasitic disease of cattle in east and central africa . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
35,
44
]
} | {
"id": "C0030499",
"name": "parasitic disease",
"pos": [
63,
80
]
} |
clinically similar syndromes cover divergent microscopical and enzymatic peroxisomal patterns , and naming of the disease should be adapted to reflect such data . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
19,
28
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
114,
121
]
} |
similar cells are also present along the crypts , where they were formerly referred to as pericryptal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
8,
13
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} |
the immunohistochemical distribution of a spectrum of collagens and procollagens was studied in 16 glioblastomas . | NA | {
"id": "C0009325",
"name": "collagens",
"pos": [
54,
63
]
} | {
"id": "C0033235",
"name": "procollagens",
"pos": [
68,
80
]
} |
substitution of a threonine residue by an alanine residue at position -2 ( p2 ) of this cleavage site abolished cleavage , whereas substitution of a tyrosine residue by a phenylalanine residue at amino acid position -1 ( p1 ) of the cleavage site did not influence processing . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
42,
49
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
196,
206
]
} |
a defined in vitro system for packaging t3 dna also packaged other linear dnas , including t4 , lambda , and plasmid dnas . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
117,
121
]
} |
in western immunoblots , 9 of these ( mr approximately 27,000-220,000 ) were recognized by a monoclonal antibody to the n protein and another 6 ( mr approximately 58,000-180,000 ) with a monoclonal antibody to the g protein , indicating that they were degradation products or aggregates of these two viral proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
122,
129
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
300,
314
]
} |
aminoacylation of trna isolated from choleraphage phi 149-infected cells with individual 3h-labeled l-amino acids followed by hybridization with phage dna revealed that the phage encodes trnas specific for arginine , proline , glycine , isoleucine , serine , valine , tyrosine , histidine , lysine , leucine , tryptophan , and aspartic acid . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
102,
113
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
227,
234
]
} |
rabbit sera , raised against the bacterial fusion protein , recognized one or two proteins of molecular weights between 30,000 and 100,000 in several ebv genome harboring burkitt lymphoma and ebv immortalized peripheral blood cell lines . | NA | {
"id": "C0004627",
"name": "bacterial",
"pos": [
33,
42
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
82,
90
]
} |
although adolescents account for only 0.4 % of reported cases of the acquired immunodeficiency syndrome ( aids ) in the united states , they are sexually active and , therefore , at risk of acquiring human immunodeficiency virus ( hiv ) infection . | NA | {
"id": "C0001175",
"name": "acquired",
"pos": [
69,
77
]
} | {
"id": "C0019693",
"name": "human immunodeficiency virus",
"pos": [
200,
228
]
} |
for adolescents of unknown antibody status with a possible previous exposure to hiv , we recommend that as long as the incidence of hiv infection and clinical aids remains low , there should be no restrictions on residential placements and no routine antibody testing . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
132,
145
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
159,
163
]
} |
alpha-interferon has a beneficial effect in some patients with low malignant non-hodgkin lymphomas ( in particular follicular lymphomas ) . | NA | {
"id": "C0024305",
"name": "non-hodgkin lymphomas",
"pos": [
77,
98
]
} | {
"id": "C0024301",
"name": "follicular lymphomas",
"pos": [
115,
135
]
} |
the reduction of mortality has been shown for streptokinase ( sk ) and apsac and various combinations ( sk and aspirin ) . | NA | {
"id": "C0078956",
"name": "apsac",
"pos": [
71,
76
]
} | {
"id": "C0038418",
"name": "sk",
"pos": [
104,
106
]
} |
urinary concn of both i and metabolites decline with time , despite continuous dosing , indicating a change in absorption , metabolism , and/or excretion of i on repeated dosing . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
124,
134
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
144,
153
]
} |
cachexia does not occur in true hypopituitarism , unless there is some intercurrent factor which causes emaciation , such as carcinoma , tuberculosis , ulceration in the alimentary tract etc . | NA | {
"id": "C0006625",
"name": "cachexia",
"pos": [
0,
8
]
} | {
"id": "C0013911",
"name": "emaciation",
"pos": [
104,
114
]
} |
an initial reaction of mononuclear cells , activated fibroblasts , and some giant cells of foreign body type in the surrounding connective tissue is followed by the development of a fibrous capsule rarefied by cells around the implant in the time up to 3 months . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
53,
64
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
210,
215
]
} |
the changes in heart rate , blood pressure , lactate , glucose , adrenaline and noradrenaline levels during the swimming exercise were equivalent in mean value to ergometry at the 100 w level . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
65,
75
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
80,
93
]
} |
in addition , there is the almost identical neurohumoral regulation of the hormones of the thyrotropic and lactotropic cells in the anterior pituitary . | NA | {
"id": "C0040160",
"name": "hormones",
"pos": [
75,
83
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
132,
150
]
} |
liver-cell hydrops seems to represent a frequent morphological equivalent of acute oxygen deficiency in asphyxia in childhood and is a common finding in sids . | NA | {
"id": "C0013604",
"name": "hydrops",
"pos": [
11,
18
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
142,
149
]
} |
the person was sustained by continuous positive-pressure respiration and died 2 days after resuscitation from drowning . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
73,
77
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
110,
118
]
} |
the results of the three methods correlated for some antibodies and were ambiguous for other mabs . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
53,
63
]
} | {
"id": "C0003250",
"name": "mabs",
"pos": [
93,
97
]
} |
a newly recognized antigen common to l. interrogans and l. biflexa spp . and an antigenic determinant common to a previously described genus-specific protein antigen ( gp-ag ) . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
80,
101
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
158,
165
]
} |
in the same test , the monoclonal antibody gp-7 against the gp-ag bound to the surface of untreated andamana and not to the surface of thimerosal-treated andamana , showing that an antigenic determinant , common to gp-ag and different from the first one , was located on the outer membrane of andamana . | NA | {
"id": "C0003320",
"name": "gp-ag",
"pos": [
60,
65
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
181,
202
]
} |
epidemiological observations strongly suggested that drinking water in those areas , i.e . non-chlorinated water from mountain stream or wells , must be the source of the infection , so we examined the waters from the epidemic areas to detect the organisms . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
53,
67
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
202,
208
]
} |
even a trivial trauma may lead to the fracture or a spinal canal diameter in the lower normal range lead to neurological symptoms . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
15,
21
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
38,
46
]
} |
studies on the action of l- and d-isomers of amino acids upon motor activity in the clawed toad revealed that most effective among them are basic amino acids ( all of them being essential ) and hydrophobic amino acids ( mainly essential ones ) . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
140,
157
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
206,
217
]
} |
the uvb- and retinol-induced arat activity was less dependent on exogenous palmitoyl-coa than that of control microsomes and experiments indicated that this might be due to an increased endogenous concentration of long-chain acyl-coa in the microsomes . | NA | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
75,
88
]
} | {
"id": "C0001374",
"name": "long-chain acyl-coa",
"pos": [
214,
233
]
} |
acitretin increased the triglyceride concentration of the very low density lipoproteins by about 50 % ( p less than 0.02 ) and reduced the cholesterol of the high density lipoproteins significantly ( p less than 0.001 ) , leading to an increased low density/high density lipoprotein cholesterol ratio ( p less than 0.02 ) . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
139,
150
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
283,
294
]
} |
however , it is important that clinician and histopathologist are both acquainted with the pathological features of this condition , as the disease often responds readily to steroid therapy . | NA | {
"id": "C0030660",
"name": "pathological",
"pos": [
91,
103
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
140,
147
]
} |
unlabelled : in order to determine the influence of thyroid function on the pineal gland in humans , the circadian rhythm of the serum melatonin concentration was estimated in 16 women with thyroid disorders : 8 with hypothyroidism and 8 with hyperthyroidism , as well as in 5 healthy controls . | NA | {
"id": "C0040128",
"name": "thyroid disorders",
"pos": [
190,
207
]
} | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
217,
231
]
} |
unlabelled : in order to determine the influence of thyroid function on the pineal gland in humans , the circadian rhythm of the serum melatonin concentration was estimated in 16 women with thyroid disorders : 8 with hypothyroidism and 8 with hyperthyroidism , as well as in 5 healthy controls . | NA | {
"id": "C0040128",
"name": "thyroid disorders",
"pos": [
190,
207
]
} | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
243,
258
]
} |
we have studied the effect of the somatomedin igf-i on stimulation of synthesis of dna , rna , protein , and glycosaminoglycan in chick chondrocytes . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
34,
45
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
46,
51
]
} |
the effects of atrial natriuretic peptide ( anp ) on mean arterial blood pressure , heart rate , plasma renin activity , aldosterone , cortisol , norepinephrine , epinephrine and arginine vasopressin were studied in 6 anuric subjects receiving regular hemodialysis . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
146,
160
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
163,
174
]
} |
the results indicate that histamine increases the release of the pro-opiomelanocortin derived peptides acth , beta-lipotropin and beta-endorphin from the anterior pituitary lobe , whereas an effect of histamine on the release of beta-endorphin from the neurointermediate lobe is possible . | NA | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
65,
85
]
} | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
110,
125
]
} |
the regulation of these enzyme reactions is still unknown but three deiodinase isoenzymes can be classified based on their physicochemical , kinetic , pharmacological and physiological properties . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
24,
30
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
79,
89
]
} |
the study includes 96 childhood epilepsies and encompasses a rather heterogeneous test population regarding type of epilepsy and/or seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
116,
124
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
132,
140
]
} |
clinical results stress the good therapeutic outcome in single drug treatment , regardless of the underlying epileptic syndrome , seizure type or serum concentration . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
109,
118
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
130,
137
]
} |
risk and benefit in the surgery of epilepsy : complications and positive results on seizures tendency and intellectual function . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
35,
43
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
84,
92
]
} |
many recent reports show that prognosis of seizures in patients with epilepsy is better than suggested in earlier studies . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
43,
51
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
69,
77
]
} |
lectin histochemical studies were performed on selected formalin-fixed , paraffin-embedded tissues of patients affected with the o variant of gm2-gangliosidosis ( i.e. , sandhoff 's disease ) . | NA | {
"id": "C0268274",
"name": "gm2-gangliosidosis",
"pos": [
142,
160
]
} | {
"id": "C0036161",
"name": "sandhoff 's disease",
"pos": [
170,
189
]
} |
maternal heart rate , cardiac output , cardiac index , placental weight and the birth weight of the infant was not correlated with placental blood flow . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
65,
71
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
80,
92
]
} |
sex cord-stromal tumors comprise approximately 5 % of ovarian neoplasms and among these the granulosa cell tumor is the one most commonly seen ( 1 ) . | NA | {
"id": "C0919267",
"name": "ovarian neoplasms",
"pos": [
54,
71
]
} | {
"id": "C0018206",
"name": "granulosa cell tumor",
"pos": [
92,
112
]
} |
in a double-blind , randomized trial , the antithrombotic effect and haemorrhagic complications of low molecular weight heparin ( lmwh ) ( heparin fragment 2165 , kabivitrum ) and unfractionated heparin ( uh ) were compared . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
99,
127
]
} | {
"id": "C0019134",
"name": "unfractionated heparin",
"pos": [
180,
202
]
} |
a case is presented of such a pregnancy detected in the second trimester routine ultrasonographic examination . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
30,
39
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
56,
72
]
} |
a normal elemental content was found in otoconia from jerker mutants , whereas in the dancer mutant a large number of otoconia from both maculae contained very high concentrations of phosphorus . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
9,
18
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
183,
193
]
} |
the capacity of the anterior pituitary to secrete prolactin ( prl ) and gonadotropins was evaluated by trh and gnrh stimulation , followed by metoclopramide ( mc ) administration 1 hour later , before and after clomiphene citrate ( cc ) priming in 8 endometriosis patients receiving gnrh agonist analog ( buserelin ) therapy for 6 months . | NA | {
"id": "C0023610",
"name": "gnrh",
"pos": [
111,
115
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
305,
314
]
} |
reduced intake of saturated fat and cholesterol can lower total and low-density lipoprotein ( ldl ) cholesterol by 10-20 percent , while several medications lower total and ldl cholesterol by 15-40 percent . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
36,
47
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
173,
188
]
} |
the efficacy and long-term safety of ingesting large amounts of omega-3 fatty acids in fish oil supplements are unproven . | NA | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
64,
83
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
87,
95
]
} |
the bzr is an allosteric modulatory site of the gabaa receptor , which is unique insofar as it mediates both a positive ( facilitatory ) and a negative ( inhibitory ) modulation of the gaba-mediated gating of the chloride channel . | NA | {
"id": "C0034807",
"name": "gabaa receptor",
"pos": [
48,
62
]
} | {
"id": "C0055363",
"name": "chloride channel",
"pos": [
213,
229
]
} |
grouping of lectin binding properties , based on determinant structure rather than monosaccharide inhibition pattern , should facilitate the selection of lectins as structural probes for glycans as well as for the interpretation of the distribution and the properties of the carbohydrate chains on the cell surface . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
83,
97
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
275,
287
]
} |
the sle ( a ) antigen , originally defined by monoclonal antibody 19-9 , is a complex carbohydrate epitope that differs from the normal human blood group lea antigen only by the presence of an additional sialic acid residue . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
14,
21
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
99,
106
]
} |
finally , the bk antagonist [ thi5,8 , d-phe7 ] -bk blocked both bk binding and the ability of either bk or dabk to induce pg synthesis , thus substantiating that the binding of these kinins is a step in the activation of pg synthesis . | NA | {
"id": "C0006100",
"name": "bk",
"pos": [
14,
16
]
} | {
"id": "C0022714",
"name": "kinins",
"pos": [
184,
190
]
} |
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