text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
putrescine , spermidine and spermine concentrations are all increased following turpentine , but with different patterns : spermidine alone keeps increasing for 50 hours . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
0,
10
]
} | {
"id": "C0037871",
"name": "alone",
"pos": [
134,
139
]
} |
putrescine , spermidine and spermine concentrations are all increased following turpentine , but with different patterns : spermidine alone keeps increasing for 50 hours . | NA | {
"id": "C0037874",
"name": "concentrations",
"pos": [
37,
51
]
} | {
"id": "C0037871",
"name": "alone",
"pos": [
134,
139
]
} |
the rapid metabolism and elimination of l-648,051 in vivo should be an advantage for a topical agent by minimizing systemic exposure . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
10,
20
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
25,
36
]
} |
treated stone locations were 593 renal stones , which contained 112 complete staghorn calculi , 504 ureteral stones , 110 renoureteral stones , and 1 bladder stone . | NA | {
"id": "C0022650",
"name": "renal stones",
"pos": [
33,
45
]
} | {
"id": "C0333014",
"name": "staghorn calculi",
"pos": [
77,
93
]
} |
after eswl , hematuria was noticed in almost cases , but the average volume of hemorrhage was 28 +/- 33 ml/day . | NA | {
"id": "C0018965",
"name": "hematuria",
"pos": [
13,
22
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
79,
89
]
} |
the main treatments were human mammary gonadotropin-human chorionic gonadotropin ( hmg-hcg ) therapy and high ligation of left testicular vein in the cases accompanied with varicocele . | NA | {
"id": "C0018062",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
68,
80
]
} |
values of lactate dehydrogenase , alpha-fetoprotein , human chorionic gonadotropin ( hcg ) and beta-hcg in the serum were markedly elevated . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
54,
82
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
95,
103
]
} |
the effect of cg-120 , a citrate compound ( potassium citrate , sodium citrate and citric acid ) produced by dr . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
25,
32
]
} | {
"id": "C0142825",
"name": "sodium citrate",
"pos": [
64,
78
]
} |
the effect of cg-120 , a citrate compound ( potassium citrate , sodium citrate and citric acid ) produced by dr . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
25,
32
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
83,
94
]
} |
the effect of cg-120 , a citrate compound ( potassium citrate , sodium citrate and citric acid ) produced by dr . | NA | {
"id": "C0137996",
"name": "potassium citrate",
"pos": [
44,
61
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
83,
94
]
} |
we report two cases of intratesticular epidermoid cyst , one of which had ossification in the cyst . | NA | {
"id": "C0014511",
"name": "epidermoid cyst",
"pos": [
39,
54
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
94,
98
]
} |
qualitative assessment of the radiographs showed that four patients had the classic findings of pulmonary hypertension including prominent central pulmonary arteries and right ventricular enlargement , three had subtle abnormalities , and one had only cardiomegaly . | NA | {
"id": "C0162770",
"name": "right ventricular enlargement",
"pos": [
170,
199
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
252,
264
]
} |
since cooke first described bronchospasm induced by acetyl salicylic acid in asthmatic patients in 1919 , numerous studies have been done with the objective of understanding the pathology , treatment and incidence of aspirin-induced asthma . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
77,
86
]
} | {
"id": "C1319853",
"name": "aspirin-induced",
"pos": [
217,
232
]
} |
effect of reperfusion on electrocardiographic and enzymatic infarct size : results of a randomized multicenter study of intravenous anisoylated plasminogen streptokinase activator complex ( apsac ) versus intracoronary streptokinase in acute myocardial infarction . | NA | {
"id": "C0078956",
"name": "anisoylated plasminogen",
"pos": [
132,
155
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
219,
232
]
} |
these patients had participated in a randomized trial comparing intravenous anisoylated plasminogen streptokinase activator complex ( apsac ) ( n = 123 ) and intracoronary streptokinase ( n = 117 ) therapy . | NA | {
"id": "C0078956",
"name": "apsac",
"pos": [
134,
139
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
172,
185
]
} |
reperfusion occurred in 59 of 115 ( 51 % ) patients receiving apsac and 67 of 111 ( 60 % ) patients receiving streptokinase ( p = ns ) . | NA | {
"id": "C0078956",
"name": "apsac",
"pos": [
62,
67
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
110,
123
]
} |
and `` '' mixed angina '' '' ( 55 patients ) , defined as exertional angina provoked by a variable threshold and/or at least two episodes of rest angina within the 3 months prior to screening . | NA | {
"id": "C0002962",
"name": "angin",
"pos": [
16,
21
]
} | {
"id": "C0002965",
"name": "r",
"pos": [
61,
62
]
} |
mean values ( mg/dl ) at baseline and week 8 in the diltiazem group were , respectively , for cholesterol 215 and 218 , high-density lipoprotein cholesterol 50 and 51 , low-density lipoprotein cholesterol 128 and 133 , triglycerides 169 and 175 , and glucose 113 and 110 . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
94,
105
]
} | {
"id": "C0023822",
"name": "high-density",
"pos": [
120,
132
]
} |
mean values ( mg/dl ) at baseline and week 8 in the diltiazem group were , respectively , for cholesterol 215 and 218 , high-density lipoprotein cholesterol 50 and 51 , low-density lipoprotein cholesterol 128 and 133 , triglycerides 169 and 175 , and glucose 113 and 110 . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
94,
105
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein cholesterol",
"pos": [
169,
204
]
} |
the proto-oncogene model conceives of cell growth regulation in terms of a limited number of classes of critical regulatory proteins : growth factors , growth factor receptors , intracellular transducing proteins and ribonucleic acid ( rna ) transcription factors . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
124,
132
]
} | {
"id": "C0040648",
"name": "transcription factors",
"pos": [
242,
263
]
} |
such changes may cause ischemia in patients with heart disease , which is a powerful stimulus for arrhythmia , or lead to dysfunction in left ventricular contraction and increased myocardial wall stress , factors that also may precipitate arrhythmia . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
49,
62
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
239,
249
]
} |
studies in patients with recurrent ventricular tachycardia demonstrate that prevention by antiarrhythmic drugs of the ability to initiate tachycardias that were previously inducible by comparable stimulation techniques in the absence of therapy is highly predictive of freedom from recurrent episodes of spontaneous ventricular tachycardia and ventricular fibrillation . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
35,
58
]
} | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
138,
150
]
} |
excellent 10-year recurrence-free rates were achieved for stages ia and ic , nonruptured cysts , and grade i and ii tumors . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
89,
94
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
116,
122
]
} |
4'demethoxydaunorubicin ( dmdr ) , an orally active daunorubicin analogue , was administered to 22 patients with advanced colorectal carcinoma . | NA | {
"id": "C0020789",
"name": "4'demethoxydaunorubicin",
"pos": [
0,
23
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
52,
64
]
} |
exogenous calcitonin therapy may have failed to control bone resorption for several reasons : insufficient dose , reduction of bone receptors from long-term calcitonin exposure , secondary hyperparathyroidism , or lack of association between calcitonin deficiency and the bone disease . | NA | {
"id": "C0005974",
"name": "bone resorption",
"pos": [
56,
71
]
} | {
"id": "C0005940",
"name": "bone disease",
"pos": [
272,
284
]
} |
animal studies of self-administration of potentially abused drugs show that benzodiazepines are less powerful reinforcers than intermediate half-life barbiturates ( such as secobarbital ) and psychomotor stimulants ( such as amphetamine and cocaine ) . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
150,
162
]
} | {
"id": "C0036516",
"name": "secobarbital",
"pos": [
173,
185
]
} |
the case of a 19-year-old woman is described in which several of the characteristic death-scene features found in cases of male autoerotic asphyxial deaths were absent . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
84,
89
]
} | {
"id": "C0004044",
"name": "asphyxial",
"pos": [
139,
148
]
} |
two nonadecamers were synthesized to serve as probes : one , entirely homologous to the normal 3 ' end of alpha 2a-globin gene sequence , including the termination codon taa , the other different from it by a replacement of the t in the termination codon taa with c , changing it to caa , the codon for the amino acid glutamine . | NA | {
"id": "C0242611",
"name": "termination codon",
"pos": [
152,
169
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
293,
298
]
} |
the kasabach merritt syndrome consists of thrombocytopenia , microangiopathic hemolytic anemia , and a localized consumption coagulopathy that develops within the abnormal vascular channels of a hemangioma . | NA | {
"id": "C0221025",
"name": "kasabach merritt syndrome",
"pos": [
4,
29
]
} | {
"id": "C0018916",
"name": "hemangioma",
"pos": [
195,
205
]
} |
the gene defect causing the fanconi anemia ( fa ) phenotype appears to be expressed at the cellular level , since fa fibroblasts show a protracted course of explant outgrowth , a diminished in vitro life span , and very poor cloning . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
91,
99
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
117,
128
]
} |
we have previously assigned two surfactant proteins , sp-a ( a 28-36-kda glycoprotein ) and sp-b ( an 18-kda hydrophobic protein ) , to the short arm of chromosome 10 and to chromosome 2 , respectively . | NA | {
"id": "C0072600",
"name": "surfactant",
"pos": [
32,
42
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
121,
128
]
} |
blood gas parameters and plasma sodium , potassium , glucose , osmolality , renin , aldosterone , epinephrine , norepinephrine , dopamine , and insulin were measured before , during , and after 60-minute infusions of bicarbonate , epinephrine , and insulin in glucose , and before , during , and after performance of regular hemodialysis for one hour . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
231,
242
]
} |
the clinical experiences with 1,500 patients receiving chloroquine or hydroxychloroquine over a 15-year period are reviewed . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
55,
66
]
} | {
"id": "C0020336",
"name": "hydroxychloroquine",
"pos": [
70,
88
]
} |
an alternative would be auranofin , whose efficacy approaches that of parenteral gold , yet may be safer . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
24,
33
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
81,
85
]
} |
these reports suggest that antimalarial drug toxicity is less than that of parenteral gold , d-penicillamine , auranofin , or dapsone . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
86,
90
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
111,
120
]
} |
these mechanisms consider the importance of peritoneal tissue-type plasminogen activator for removal of fibrin clots and suggest that polymer coating either prevents the shedding of plasminogen activator into the abdominal cavity or reduces the access of fibrin clots to the serosal surfaces . | NA | {
"id": "C0032143",
"name": "tissue-type plasminogen activator",
"pos": [
55,
88
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
182,
193
]
} |
we studied the influence of cataracts on visual fields in 36 eyes of 36 patients before and after cataract extraction with intraocular lens implantation . | NA | {
"id": "C0086543",
"name": "cataracts",
"pos": [
28,
37
]
} | {
"id": "C1306068",
"name": "after cataract",
"pos": [
92,
106
]
} |
autoradiography studies revealed that increased proteoglycan synthesis in t. pallidum-infected testes was localized to cells lining the seminiferous tubules and to fibroblasts infiltrating peritubular spaces . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
major categories of clinical presentation included a mononucleosislike syndrome , gastrointestinal/abdominal disease , and solid organ disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
71,
79
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
135,
142
]
} |
the methods involved the incubation of llc-pk1 cells with [ 3h ] inositol for its incorporation into membrane pi and the measurement of the release of [ 3h ] ip in the presence of licl which prevents dephosphorylation . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
65,
73
]
} | {
"id": "C0021554",
"name": "ip",
"pos": [
158,
160
]
} |
to investigate the timing of inositol lipid turnover in relation to the cell cycle , inositol phosphates and lipids were measured in neuroblastoma ( neuro-2a ) cells that were prelabeled with [ 3h ] inositol and synchronized by a mitotic shakeoff technique . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
85,
104
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
199,
207
]
} |
in testicular membranes of hcg-treated animals , a depletion of cholesterol and an increase in total phospholipid content was observed after gonadotropin injection , thereby decreasing the cholesterol-to-phospholipid ratio . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
27,
30
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
141,
153
]
} |
to assess the effect of arginine vasopressin ( avp ) and 1-deamino-8-d-avp ( ddavp ) on atrial natriuretic peptide ( anp ) release , renal water and electrolyte excretion , and cardiovascular function , avp and ddavp were administered at a dose of 10 ng.kg-1.min-1 iv for 30 min into anesthetized dogs receiving saline infusion at a rate of 1 ml.kg-1.min-1 ( n = 12 ) . | NA | {
"id": "C0011701",
"name": "atrial natriuretic peptide",
"pos": [
88,
114
]
} | {
"id": "C0003779",
"name": "avp",
"pos": [
213,
216
]
} |
although both procedures induced a similar dramatic fall in norepinephrine and epinephrine concentrations ( -55 to -65 % ) measured by high-performance liquid chromatography in pvn punches , the vnab lesion , unlike pvn denervation , depleted the median eminence ( me ) of both amines ( -80 % ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
79,
90
]
} |
this study shows that during growth hormone-stimulated muscle growth mrnas for both igf-i and igf-ii accumulate , supporting other observations implicating the igfs as paracrine or autocrine factors involved in skeletal muscle growth . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
84,
89
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
160,
164
]
} |
this study shows that during growth hormone-stimulated muscle growth mrnas for both igf-i and igf-ii accumulate , supporting other observations implicating the igfs as paracrine or autocrine factors involved in skeletal muscle growth . | NA | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
94,
100
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
160,
164
]
} |
hyperpolarization of hepatocytes with lipophilic anions , thiocyanate , and nitrate was associated with significantly increased efflux . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
49,
55
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
76,
83
]
} |
to assess the role of angiotensin ii in the control of papillary blood flow , kinin receptors were blocked by infusion of an antagonist , and the effects of enalaprilat and saralasin were studied . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
22,
36
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
173,
182
]
} |
dilution and bi-ionic potential measurements showed that the epithelium of the canals exhibited only slight cation selectivity . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
16,
21
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
108,
114
]
} |
bsc-1 cells continuously released a mitogenic activity for fibroblasts and a chemoattractant activity for smooth muscle cells , each of which was inhibited 80-90 % by an antibody to human pdgf . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} |
the relationship between adrenal ( preganglionic ) sympathetic nerve activity ( adsna ) , cardiac sympathetic nerve activity ( csna ) , and arterial catecholamines , i.e. , epinephrine ( epi ) and norepinephrine ( ne ) , were analyzed during 200 s of occlusion of left anterior descending coronary artery in anesthetized cats . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
173,
184
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
197,
211
]
} |
arterial ne and epi progressively increased from 0.54 +/- 0.05 and 0.29 +/- 0.03 ng/ml to 1.41 +/- 0.16 and 0.59 +/- 0.08 ng/ml at 3 min after the onset of occlusion , respectively . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
9,
11
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
16,
19
]
} |
the correlation between adsna and arterial epi ( r = 0.71 ; p less than 0.01 ) and between adsna and arterial ne ( r = 0.57 ; p less than 0.05 ) were significant , but the correlation between csna and arterial ne was not significant . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
43,
46
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
210,
212
]
} |
on the other hand , in adrenalectomized cats , the increases in arterial epi and ne did not appear during coronary occlusion . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
73,
76
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
81,
83
]
} |
we concluded that , with coronary occlusion , adsna increased and , in turn , caused an increase in arterial epi and ne . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
109,
112
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
117,
119
]
} |
on the contrary , an increased to of ne in the kidney cortex and an elevated to of dopamine associated with an increased epinephrine content in the adrenal medulla were observed in 5-wk-old lh rats , which could participate in the development of hypertension in the lyon model . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
37,
39
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
121,
132
]
} |
it is suggested that pgs synthesized in the central nervous system contribute to the il 1 fever and that part of il 1-alpha given peripherally is also transmitted into the central nervous system to contribute to il 1 fever . | NA | {
"id": "C0600251",
"name": "il 1-alpha",
"pos": [
113,
123
]
} | {
"id": "C0021755",
"name": "il 1",
"pos": [
212,
216
]
} |
for those who could be evaluated , the following immune deficiencies were found : decreased lymphocyte proliferation to mitogens ( 4 of 9 ) , absent or markedly decreased natural killer function ( 5 of 5 ) , and decreased cytotoxic lymphocyte reactivity to allogenic ebv-infected target cells ( 3 of 3 ) . | NA | {
"id": "C0021051",
"name": "immune deficiencies",
"pos": [
49,
68
]
} | {
"id": "C0024312",
"name": "decreased lymphocyte",
"pos": [
82,
102
]
} |
pyridoxal 5'-phosphate ( plp ) , the major coenzyme form of vitamin b6 , is known to have antisickling properties in vitro . | NA | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
0,
11
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
43,
51
]
} |
they are a heterogeneous group of tissues that contain fibroblasts ( type example -- the subcutaneous mucochondroid of the cobitidae ) or hyaline cells ( type example -- the mucochondroid around the medulla oblongata and spinal cord of rasbora heteromorpha ) , embedded in a pale-staining matrix in which there are variable numbers of collagen fibres and blood vessels . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
146,
151
]
} |
the effects of intravenous administration of high-dose fentanyl ( 100 micrograms.kg-1 , loading dose followed by an infusion of 200 micrograms.kg-1.h-1 ) were compared with those of a barbiturate ( pentobarbital sodium 25 mg.kg-1 , intraperitoneal ) or hypothermia ( rectal temperature 32 degrees c ) on changes in cerebral cortical tissue levels of adenosine triphosphate ( atp ) , phosphocreatine ( pcr ) , lactate , and glucose in severely hypoxemic rats ( pao2 13-23 mmhg for 20 min ) with unilateral ( left side ) carotid ligation ( 10-12 animals in each group ) . | NA | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
184,
195
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
198,
211
]
} |
the complement levels ( c3 , c4 , ch50 ) in different arterial diseases were measured , and the relationship of complement levels to serum lipids in patients with arteriosclerosis obliterans ( aso ) was also investigated , in order to clarify a relationship between the complement system and arteriosclerosis or other arterial diseases . | NA | {
"id": "C0003851",
"name": "arteriosclerosis obliterans",
"pos": [
163,
190
]
} | {
"id": "C0003850",
"name": "arteriosclerosis",
"pos": [
292,
308
]
} |
that is , determination of the antigenic epitopes that trigger helper t cells should permit the construction of peptides that can `` '' block '' '' t cell recognition and potentially lead to immunologic unresponsiveness . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
31,
40
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
41,
49
]
} |
immunophenotypic analysis of peripheral blood mononuclear cells showed a significant decrease in helper ( cd 4 ) cells with a normal concentration of suppressor ( cd 8 ) cells . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
29,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
170,
175
]
} |
saliva and serum protein profiles composed of 12 proteins : iga , igg , igm , albumin , transferrin , alpha 1-glycoprotein acid , alpha 2-macroglobulin , alpha 1-proteinase inhibitor , haptoglobine , c3c , c4 and crp were obtained by laser nephelometry of aliquots of samples of non-stimulated whole saliva and blood taken at the same time . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
49,
57
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
78,
85
]
} |
using the techniques developed for saliva assay , 10 proteins were measurable : iga , igg , igm , albumin , transferrin , alpha 1-glycoprotein acid , alpha 2-macroglobulin , alpha 1-proteinase inhibitor , haptoglobulin and c3c . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
53,
61
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
98,
105
]
} |
thirty-one horses with secondary osteoarthritis as a sequel of trauma ( chip fractures ) or osteochondritis dissecans were screened for immune complexes ( ic ) and anticollagen antibodies . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
136,
152
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
177,
187
]
} |
lung lesions were characterized by bronchitis and bronchiolitis , hyperplasia of bronchial and bronchiolar epithelium , peribronchiolar and perivascular accumulations of lymphocytes , alveolar septal thickening , and collapse . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
35,
45
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
50,
63
]
} |
body composition , lipid , lipoprotein and apoprotein profiles were evaluated in 38 female adolescents , with ages from 11.5 to 15.0 years , and arranged in three groups : controls , swimmers and rhythmic gymnasts . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
19,
24
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
27,
38
]
} |
differences between sports girls and controls are more significantly revealed by lipid , lipoprotein and apoprotein relating ratios . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
81,
86
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
89,
100
]
} |
aromatic amino acids tyrosine and phenylalanine have been measured on paper with dried blood samples , using high performance liquid chromatography ( hplc ) in reverse phase . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
0,
20
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
21,
29
]
} |
aromatic amino acids tyrosine and phenylalanine have been measured on paper with dried blood samples , using high performance liquid chromatography ( hplc ) in reverse phase . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
0,
20
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
34,
47
]
} |
both the macrophage product rif and the t-cell product interleukin-4 efficiently induce the il-2 responsiveness in resting lyt-2+ t cells exposed in vitro either to the ligand con a , or to immobilized f23 mab , or to nonimmunogenic allogeneic stimulator cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
5,
8
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
233,
243
]
} |
human cholinesterase exists in two forms -- acetylcholinesterase located in tissue microsomes and red blood cells and serum cholinesterase found in serum or plasma . | NA | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
6,
20
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
44,
64
]
} |
an investigation of a range of tissue homogenates by various electrophoretic methods , followed by staining for specific enzyme activity , has revealed a series of isozymes of human rhodanese . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
121,
127
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
164,
172
]
} |
doxorubicin-resistant s180 cells , daunorubicin-resistant l1210 cells and vincristine-resistant human epidermoid lung carcinoma xenografts showed an intense positive reaction with the monoclonal antibody . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
0,
11
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
35,
47
]
} |
dfmo treatment alone , or in combination with nspd reduced tumoral put and spd levels by greater than 50 % in all three tumor models . | NA | {
"id": "C0034170",
"name": "put",
"pos": [
67,
70
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
79,
85
]
} |
tumor and tissue distribution of 125i-labeled natural and antitumor antibodies in murine experimental tumor systems . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
0,
5
]
} | {
"id": "C0027659",
"name": "experimental tumor",
"pos": [
89,
107
]
} |
idarubicin ( 4-demethoxydaunorubicin ) is a daunorubicin analog that has shown comparable activity and less cardiotoxicity than daunorubicin and doxorubicin in preclinical studies . | NA | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
13,
36
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
128,
140
]
} |
idarubicin ( 4-demethoxydaunorubicin ) is a daunorubicin analog that has shown comparable activity and less cardiotoxicity than daunorubicin and doxorubicin in preclinical studies . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
24,
36
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
145,
156
]
} |
immortalization of the fibroblast population is accompanied by the appearance of cells with new properties , favoring the hypothesis that the immortal cells are not present in the primary culture . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
23,
33
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
purines such as hypoxanthine and 6-thioguanine have the capacity to induce the differentiation of human myeloid leukemia hl-60 cells in culture . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
0,
7
]
} | {
"id": "C0039902",
"name": "6-thioguanine",
"pos": [
33,
46
]
} |
the inhibitory profiles of several proteinase-like peptidases active on synthetic peptide ( mca ) substrates , present in sera and 100,000g supernatants of malignant tissue from patients with breast cancer , have been studied using a series of known inhibitors including epoxysuccinyl peptides ( e-64 , ep-475 ) , z-phe-phe-diazomethane , pmsf , iodoacetamide , 1-10-o-phenanthroline , leupeptin , aprotinin , elastatinal and alpha 2-macroglobulin . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
35,
45
]
} | {
"id": "C0030940",
"name": "peptidases",
"pos": [
51,
61
]
} |
comparison of growth inhibition of a human ovarian adenocarcinoma cell line by free monoclonal antibodies and their corresponding antibody-recombinant ricin a chain immunotoxins . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
84,
105
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
130,
138
]
} |
this occurs by modulating colony stimulating factor and erythropoietin production in response to lactoferrin and oxygen tension respectively . | NA | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
26,
51
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
56,
70
]
} |
human fibroblasts immortalized by repeated treatment with co-60 gamma rays were transformed into tumorigenic cells with ha-ras oncogenes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
6,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
109,
114
]
} |
two normal mortal human fibroblast cell strains were transformed into immortal cell lines , susm-1 and kmst-6 , by treatment with 4-nitroquinoline 1-oxide ( 4nqo ) and co-60 gamma rays , respectively . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
4,
10
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
24,
34
]
} |
normal human fibroblasts , on the other hand , were not transformed into either immortal or tumorigenic cells by treatment with ha-msv or c-ha-ras alone . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
104,
109
]
} |
although ras cooperates with myc and fos oncogenes to transform c3h10t1/2 fibroblasts , cooperative transformation is not observed in cells similarly co-transfected with the h-ras and e1a oncogenes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
74,
85
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
134,
139
]
} |
influence of unsaturated fatty acid membrane component on sensitivity of an escherichia coli fatty acid auxotroph to conditions of nutrient depletion . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
13,
35
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
93,
103
]
} |
however , when precipitation of phosphate-magnesium or acetyl phosphate-magnesium was promoted by addition of dimethyl sulfoxide , phosphorolysis was observed with rate constants as high as those found in the presence of calcium . | NA | {
"id": "C0065527",
"name": "phosphate-magnesium",
"pos": [
32,
51
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
72,
81
]
} |
dermatan sulfate having a chondroitin-type structure also stimulated hyaluronic acid synthesis but this effect was not additive to the stimulation of hyaluronic acid synthesis by gagps . | NA | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
0,
16
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
26,
37
]
} |
these findings suggest that monovalent cations and anions , particularly potassium and phosphate , cause structural changes in the dehydrogenase-kinase complex that alter its susceptibility to phosphorylation and responsiveness to kinase inhibitors . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
51,
57
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
87,
96
]
} |
other intermediates in the porphyrin biosynthetic pathway , uroporphyrinogen iii , uroporphyrin iii , and protoporphyrin ix , do not decrease the labeling of the 43-kda protein appreciably . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
27,
36
]
} | {
"id": "C0033733",
"name": "protoporphyrin ix",
"pos": [
106,
123
]
} |
in 13 of 24 patients ( 54.1 % ) , abnormal menses , including amenorrhea in 12 cases and oligomenorrhea in 1 case , developed during adjuvant therapy . | NA | {
"id": "C0025345",
"name": "abnormal menses",
"pos": [
34,
49
]
} | {
"id": "C0002453",
"name": "amenorrhea",
"pos": [
62,
72
]
} |
the increase of hydroxyl radical production stimulated by rhtnf was also detected in tnf sensitive human myosarcoma derived kym cells as well as in l-m cells , but no change was detected in tnf insensitive human embryonic lung fibroblast hel cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
227,
237
]
} |
major subjective and objective symptoms were fever ( 38.7 % ) , fatigue ( 25.8 % ) , anorexia ( 12.9 % ) and nausea ( 12.9 % ) , and leukopenia ( 22.6 % ) , granulocytopenia ( 38.7 % ) , thrombocytopenia ( 38.7 ) , elevation of gpt ( 12.9 % ) and got ( 12.9 % ) were observed . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
133,
143
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
157,
173
]
} |
immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-a lambda serum in both patients . | NA | {
"id": "C1456454",
"name": "amyloid",
"pos": [
76,
83
]
} | {
"id": "C0002716",
"name": "amyloid",
"pos": [
125,
132
]
} |
among the 20 additional variables analyzed -- including hypertension , smoking , diabetes mellitus , and etiology of primary vascular disease -- no statistically significant influence on the development of rfaas could be detected . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
56,
68
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
125,
141
]
} |
in a study of the effects of propranolol hydrochloride ( a hepatically metabolized beta-blocker ) vs hydrochlorothiazide , 108 smokers and 232 nonsmokers were randomized to the propranolol treatment group . | NA | {
"id": "C0282321",
"name": "propranolol",
"pos": [
29,
40
]
} | {
"id": "C0033497",
"name": "propranolol",
"pos": [
177,
188
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.