text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the absorption , metabolism and excretion of ketanserin [ + ) -3- [ 2- [ 4- ( 4-fluorobenzoyl ) -1-piperidinyl ] ethyl ] -2,4 ( 1h,3h ) - quinazolinedione , r 41 468 ) , a novel serotonin s2-receptor antagonist used in hypertension , was studied after a single oral dose of 14c-ketanserin tartrate in three healthy subjects . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
although this preparation is known to exhibit high antibody titers against the lipid a moiety of lipopolysaccharides , no specific binding with the intact lipopolysaccharide can be found . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
79,
86
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
155,
173
]
} |
the effect of a single bedtime dose ( 7.5 or 15 mg ) of 8-chloro-6- ( 2-fluorophenyl ) -1-methyl-4h-imidazol [ 1,5-a ] [ 1,4 ] benzodiazepine ( midazolam , ro 21-3981 , dormicum ) on memory was investigated in young , healthy adults . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
127,
141
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
144,
153
]
} |
in analogy with data obtained from other mammalian species it appears that the majority of physiologically relevant human hemopoietic growth factors ( e.g . erythropoietin and colony stimulating factors ) has been characterized in biological systems , defined by biochemical methods and manufactured by molecular cloning of the corresponding genetic elements and expression in suitable biological systems . | NA | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
157,
171
]
} | {
"id": "C0009392",
"name": "colony stimulating factors",
"pos": [
176,
202
]
} |
the presence of the two distinct antigens in the lipoprotein permitted the development of an enzyme-linked immunosorbent assay that was specific for lp ( a ) particles in serum . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
49,
60
]
} | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
149,
155
]
} |
the assay was specific for lp ( a ) and did not respond to other lipoproteins , such as low density lipoprotein . | NA | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
27,
33
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
65,
77
]
} |
we report a case of successful transcutaneous external pacing for out of hospital cardiac arrest causing asystole . | NA | {
"id": "C2936490",
"name": "out of",
"pos": [
66,
72
]
} | {
"id": "C0018790",
"name": "asystole",
"pos": [
105,
113
]
} |
to determine the incidence of bacterial pneumonia in a well defined population of intravenous drug users ( ivdus ) , and to examine any association with hiv infection , we prospectively studied 433 ivdus without aids , enrolled in a longitudinal study of hiv infection in an out-patient methadone maintenance program . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
212,
216
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
255,
268
]
} |
this study shows a markedly increased incidence of bacterial pneumonia associated with hiv infection in ivdus without aids . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
87,
100
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
118,
122
]
} |
ice water tests ( iwt ) and gas cystometrograms were performed on 30 consecutive spinal cord injury in-patients on an intermittent catheterization program over a 6-month period . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
0,
3
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
4,
9
]
} |
a three-step grading system was formulated to clinically determine the degree of detrusor reflex activity on iwt . | NA | {
"id": "C0020746",
"name": "iwt",
"pos": [
109,
112
]
} | {
"id": "C0043047",
"name": "iwt",
"pos": [
109,
112
]
} |
a 3+ iwt was used to indicate the expulsion of the catheter from the bladder and urethra following instillation of recently thawed ice ; | NA | {
"id": "C0043047",
"name": "iwt",
"pos": [
5,
8
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
131,
134
]
} |
a 2+ iwt meant voiding around the catheter after instillation of 90 ml of ice water ; | NA | {
"id": "C0043047",
"name": "iwt",
"pos": [
5,
8
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
74,
77
]
} |
and a 1+ iwt indicated voiding around the catheter after instilling a total of 300 ml of ice water into the bladder . | NA | {
"id": "C0043047",
"name": "iwt",
"pos": [
9,
12
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
89,
92
]
} |
the study shows that the ice water test was more sensitive test than co2 cystometrogram in detecting the presence of detrusor reflex activity . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
25,
28
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
29,
34
]
} |
recent evidence to suggest that an inherited predisposition to raised arterial pressure may confer the susceptibility to diabetic nephropathy is presented . | NA | {
"id": "C0314657",
"name": "inherited predisposition",
"pos": [
35,
59
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
103,
117
]
} |
in contrast , while taurine uptake in a calcium-free medium was impaired in both cf and control fibroblasts , the impairment was significantly less in cf cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
a quantitative scleritis scoring system has been developed and its application to the assessment and management of scleral disease is discussed . | NA | {
"id": "C0036416",
"name": "scleritis",
"pos": [
15,
24
]
} | {
"id": "C0036412",
"name": "scleral disease",
"pos": [
115,
130
]
} |
the structure of the nh from b. melitensis 16m ( nh-m ) was identified as a linear homopolysaccharide of the same sugar but composed of a pentasaccharide repeating unit in which four alpha 1,2-linked-4,6-dideoxy-4-formamido-d-mannopyrannosyl residues are linked alpha-1,3 to the last monosaccharide of the sequence . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
114,
119
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
284,
298
]
} |
among the beta-lactamases not neutralized by either serum were the plasmid-mediated oxa-enzymes , various species-specific beta-lactamases and cephalosporinases . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
10,
25
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
143,
160
]
} |
absorption of immune sera against serotypes o:3 , o:8 and o:9 with their heterologous antigens ( s-lps ) was necessary to avoid the appearance of different cross-reactions , as observed by co-agglutination . | NA | {
"id": "C0069180",
"name": "o",
"pos": [
3,
4
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
99,
102
]
} |
potential gains in life expectancy of kuwaiti nationals through partial and complete elimination of infectious and parasitic disease mortality . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
100,
110
]
} | {
"id": "C0030499",
"name": "parasitic disease",
"pos": [
115,
132
]
} |
this study attempts to estimate potential gains in life expectancy in 1984 through partial and complete elimination of infectious and parasitic diseases among kuwaiti nationals . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
119,
129
]
} | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
134,
152
]
} |
the results of the study show that complete elimination of infectious and parasitic disease mortality would further add 0.45 years to the life expectancy at birth of kuwaiti males and 0.54 yr to that of kuwaiti females . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
59,
69
]
} | {
"id": "C0030499",
"name": "parasitic disease",
"pos": [
74,
91
]
} |
recently the calcium-channel blocker , verapamil , has been reported to decrease portal pressure in rats with experimental cirrhosis and in patients with liver cirrhosis . | NA | {
"id": "C0023893",
"name": "experimental cirrhosis",
"pos": [
110,
132
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
154,
169
]
} |
the peptide showed hcg-b subunit activity and no hcg-alpha subunit activity as demonstrated by binding studies with the relevant antibodies . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
19,
22
]
} | {
"id": "C0017963",
"name": "hcg-alpha subunit",
"pos": [
49,
66
]
} |
the inn 13 antibody reacted with only the syncytiotrophoblast cells of choriocarcinoma , hydatidiform mole , placental site trophoblastic tumour , and in one case of seminoma ; | NA | {
"id": "C0008497",
"name": "choriocarcinoma",
"pos": [
71,
86
]
} | {
"id": "C0206666",
"name": "placental site",
"pos": [
109,
123
]
} |
compared with controls , mothers of cryptorchid sons ( cases ) had significantly greater percentages of non-protein bound ( p = 0.010 ) and albumin-bound ( p = 0.014 ) estradiol during the first trimester of the index pregnancy . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
108,
115
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
140,
147
]
} |
in one set ( experiment a ) preformed 125i-bsa-anti-bsa complexes ( which consisted of heterologous ( rabbit ) antibodies ) were incubated with peritoneal macrophages and pmns from normal and nephritic rats at 37 degrees c for between 1 h and 24 h and the degradation rates of ics were studied . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} | {
"id": "C0003313",
"name": "ics",
"pos": [
277,
280
]
} |
in the other set ( experiment b ) , homologous ics prepared from antibodies derived from the sera of nephritic rats were examined using macrophages and pmns from normal rats . | NA | {
"id": "C0003313",
"name": "ics",
"pos": [
47,
50
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
65,
75
]
} |
in cell cultures of human embryonal lung ( hel ) fibroblasts , addition to the culture medium of alpha 1-ag promoted cell growth . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
3,
7
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
49,
60
]
} |
keratinocytes were similar to fibroblasts in showing reduced proliferation in low ( 0.15 mm ) calcium medium and unlike b16 cells which continued to proliferate until calcium was reduced to submicromolar levels . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
fibroblasts and b16 cells maintained similar calmodulin levels in both low and normal calcium media . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
20,
25
]
} |
thus , keratinocyte calmodulin seems related to the proliferative state of the cell ( unlike fibroblast calmodulin ) and calmodulin antagonists may be of use in controlling the hyperproliferation of the psoriatic epidermis . | NA | {
"id": "C0022567",
"name": "calmodulin",
"pos": [
20,
30
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
79,
83
]
} |
thus , keratinocyte calmodulin seems related to the proliferative state of the cell ( unlike fibroblast calmodulin ) and calmodulin antagonists may be of use in controlling the hyperproliferation of the psoriatic epidermis . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
79,
83
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
93,
103
]
} |
a pattern of evolution could be identified in these patients revealing well-documented saa - improvement of bone marrow haematopoiesis - dyshaematopoietic features of one or more cell lines with predominance of dyserythropoiesis - ra - raeb or cmml - aml . | NA | {
"id": "C0002893",
"name": "ra",
"pos": [
231,
233
]
} | {
"id": "C0002894",
"name": "raeb",
"pos": [
236,
240
]
} |
compared to compounds ii in other peroxidases , the electronic and vibrational properties of this intermediate are strongly perturbed due to the unusual active-site iron chromophore that occurs in myeloperoxidase . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
34,
45
]
} | {
"id": "C0027021",
"name": "myeloperoxidase",
"pos": [
197,
212
]
} |
despite this difference in prosthetic group , however , other properties of myeloperoxidase compound ii are similar to those observed for this intermediate in the more common peroxidases ( horseradish peroxidase in particular ) . | NA | {
"id": "C0027021",
"name": "myeloperoxidase",
"pos": [
76,
91
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
175,
186
]
} |
despite this difference in prosthetic group , however , other properties of myeloperoxidase compound ii are similar to those observed for this intermediate in the more common peroxidases ( horseradish peroxidase in particular ) . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
175,
186
]
} | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
189,
211
]
} |
purified cytochrome p-450g , a male-specific rat hepatic isozyme , was observed to metabolize progesterone to two primary metabolites ( 6 beta-hydroxyprogesterone and 16 alpha-hydroxyprogesterone ) , two secondary metabolites ( 6 beta,16 alpha-dihydroxyprogesterone and 6-ketoprogesterone ) , and one tertiary metabolite ( 6-keto-16 alpha-hydroxyprogesterone ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
94,
106
]
} | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
244,
265
]
} |
concerted oxidation of progesterone to secondary products without the intermediate products leaving the active site was suggested by these results and confirmed by isotopic dilution experiments in which little or no dilution of metabolically formed 6 beta,16 alpha-dihydroxyprogesterone and 6-keto-16 alpha-hydroxyprogesterone was observed in incubations containing a mixture of radiolabeled progesterone and unlabeled 6 beta-hydroxyprogesterone or 16 alpha-hydroxyprogesterone . | NA | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
265,
286
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
465,
477
]
} |
concerted oxidation of progesterone to secondary products without the intermediate products leaving the active site was suggested by these results and confirmed by isotopic dilution experiments in which little or no dilution of metabolically formed 6 beta,16 alpha-dihydroxyprogesterone and 6-keto-16 alpha-hydroxyprogesterone was observed in incubations containing a mixture of radiolabeled progesterone and unlabeled 6 beta-hydroxyprogesterone or 16 alpha-hydroxyprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
23,
35
]
} | {
"id": "C0020387",
"name": "hydroxyprogesterone",
"pos": [
458,
477
]
} |
the v and v/knadph profiles indicate that a single ionizing group at the active center of the enzyme must be protonated for catalysis , whereas the ki profiles show that the binding of nadph to the free enzyme and of atp-ribose to the enzyme-dihydrofolate complex is ph independent . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
94,
100
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
235,
241
]
} |
the ph-rate profile demonstrated a chloride-dependent alkaline shift , with the ph optimum increasing from 7.1 at zero chloride to 7.6 at 400 mm nacl . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
35,
43
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
145,
149
]
} |
31p nmr measurements were made ( at 121.5 mhz and 5 degrees c ) on enzyme-bound substrate complexes of 3-phosphoglycerate kinase in order to address three questions pertaining to ( i ) the integrity of the enzyme-substrate complexes with mg ( ii ) in the presence of sulfate concentrations typical of those used for crystallization in x-ray studies , ( ii ) the relative affinities of mg ( ii ) to atp bound at the two sites on the enzyme , and ( iii ) the ph behavior of the different phosphate groups in the enzyme complexes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
67,
73
]
} | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
510,
526
]
} |
an enzyme has been isolated from cell-free extracts of streptomyces antibioticus that can catalyze the reduction of 8-ketodeoxycoformycin ( 8-ketodcf ) and 8-ketocoformycin ( 8-ketocof ) to the naturally occurring nucleoside analogues 2'-deoxycoformycin ( dcf ) and coformycin ( cof ) , respectively . | NA | {
"id": "C0030896",
"name": "deoxycoformycin",
"pos": [
122,
137
]
} | {
"id": "C0009239",
"name": "coformycin",
"pos": [
266,
276
]
} |
this is the same configuration of the hydroxyl group as that of the dcf and cof isolated from s. antibioticus . | NA | {
"id": "C0030896",
"name": "dcf",
"pos": [
68,
71
]
} | {
"id": "C0009239",
"name": "cof",
"pos": [
76,
79
]
} |
these in vitro results , which show that 8-ketodcf and 8-ketocof may be intermediates in the biosynthesis of dcf and cof , support and extend our earlier results from in vivo studies which established that adenosine and c-1 of d-ribose are the carbon-nitrogen precursors of dcf . | NA | {
"id": "C0009239",
"name": "cof",
"pos": [
61,
64
]
} | {
"id": "C0030896",
"name": "dcf",
"pos": [
274,
277
]
} |
the resonance raman spectrum of turnip cytochrome f is similar to that of other c-type cytochromes with the exception of a single band at 1532 cm-1 which is shifted to lower frequency relative to its position ( 1542-1545 cm-1 ) in other c-type cytochromes . | NA | {
"id": "C1256752",
"name": "c-type cytochromes",
"pos": [
80,
98
]
} | {
"id": "C0010798",
"name": "cytochromes",
"pos": [
244,
255
]
} |
comparative two-dimensional peptide mapping reveals that both proteins are present in band 4.9 on one-dimensional gels of total erythrocyte membrane proteins and membrane skeleton proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
62,
70
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
162,
170
]
} |
( h ) the initial slope of arrhenius plots of percent hemolysis at the concentration of maximum protection is negative for cis-unsaturated fatty acids and positive for saturated and trans-unsaturated fatty acids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty",
"pos": [
127,
144
]
} | {
"id": "C1257879",
"name": "trans",
"pos": [
182,
187
]
} |
in a mixed endoplasmic and surface-type membrane vesicle preparation from human platelets the polyphosphoinositides pip and pip2 , similarly to ip3 , were found to induce a rapid calcium release reaction . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
94,
115
]
} | {
"id": "C0070798",
"name": "pip2",
"pos": [
124,
128
]
} |
the temperature dependence of ouabain-sensitive atpase and phosphatase activities of membrane fragments containing the na+/k+-atpase were investigated in tissue from ox kidney , ox brain and from shark rectal glands . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
48,
54
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
119,
121
]
} |
even though the phorbol ester 12-o-tetradecanoylphorbol 13-acetate ( tpa ) is known to bind to and activate protein kinase c ( pkc ) , it is still not certain that all cellular responses to phorbol esters are necessarily mediated by pkc . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
30,
66
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
190,
204
]
} |
the urinary epithelium from the toad responds to six adrenoceptor agonists : ( - ) -epinephrine , ( - ) -norepinephrine , ( - ) -phenylephrine , clonidine , methoxamine and oxymetazoline . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
84,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
105,
119
]
} |
other protein kinases , including cyclic amp- and cyclic gmp-dependent protein kinase , s6/h4 kinase , myosin light-chain kinase and calcium/calmodulin-dependent kinase ii , had little or no activity with these peptides . | NA | {
"id": "C0027120",
"name": "myosin light-chain kinase",
"pos": [
103,
128
]
} | {
"id": "C0006776",
"name": "calmodulin",
"pos": [
141,
151
]
} |
the purified protein exhibited a high specific antiviral activity of 7 x 10 ( 7 ) units/mg when assayed on human fibroblast cells and , in distinction to the parental huifn alpha 2 , it also demonstrated antiviral activity on human fibroblast cells and , in distinction to the parental huifn alpha 2 , it also demonstrated antiviral activity on murine l929 cells . | NA | {
"id": "C0016030",
"name": "fibroblast cells",
"pos": [
113,
129
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
357,
362
]
} |
the mixing of gum guar with lectin and with modified lectin , respectively , led to the highest values of beta-conformational change in the protein molecule , thereby increasing the number of receptor sites of the lectin molecule . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
28,
34
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
140,
147
]
} |
heparin glycosaminoglycan partially stabilized the tryptase but addition of protein ( e.g . albumin , 80 micrograms/ml ) to the tryptase-heparin mixture was needed to keep the enzyme stabile . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
8,
25
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
137,
144
]
} |
the hepatic concentrations of free and esterified cholesterol were significantly increased in corn oil-fed animals , as were cholesterol concentrations in intestine , adipose tissue , muscle and total carcass . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
39,
61
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
125,
136
]
} |
deprivation of cultured h4 rat hepatoma cells for an essential amino acid ( leucine , methionine , tryptophan or phenylalanine ) under conditions in which the cells remain highly viable leads to a decrease in cytoplasmic albumin mrna . | NA | {
"id": "C0002525",
"name": "essential amino acid",
"pos": [
53,
73
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
86,
96
]
} |
the purified type ii pde described here is physicochemically very similar to the isozyme purified from the cytosolic fraction of several bovine tissues with the exception that it is predominantly a particulate enzyme . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
81,
88
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
210,
216
]
} |
in parietal cell homogenates , using [ gamma-32p ] atp , camp elicited significant phosphorylation of eight supernatant proteins and twelve microsomal proteins , which included the histamine-dependent phosphoproteins found in the intact parietal cell , except for the 51 kda microsomal protein . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
201,
216
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
286,
293
]
} |
the effect of ionization potentials , hydration energy and ionic radii of cations on their inhibiting activity is discussed . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
59,
64
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
74,
81
]
} |
extracellular guanyl-specific rnaase of the fungus aspergillus pallidus ( rnaase api ) was isolated in preparative amounts with a 40 % yield and purified to homogeneity ( 938-fold ) . | NA | {
"id": "C0018364",
"name": "guanyl-specific rnaase",
"pos": [
14,
36
]
} | {
"id": "C0014241",
"name": "rnaase",
"pos": [
74,
80
]
} |
the complete amino acid sequence of the protein ( 104 amino acid residues ) was determined : 6 asp , 4 asn , 4 thr , 14 ser , 3 glu , 4 gln , 4 pro , 15 gly , 9 ala , 4 cys , 6 val , 2 ile , 4 leu , 10 tyr , 4 phe , 3 his , 4 arg , 1 trp . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
13,
23
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
153,
156
]
} |
the complete amino acid sequence of the protein ( 104 amino acid residues ) was determined : 6 asp , 4 asn , 4 thr , 14 ser , 3 glu , 4 gln , 4 pro , 15 gly , 9 ala , 4 cys , 6 val , 2 ile , 4 leu , 10 tyr , 4 phe , 3 his , 4 arg , 1 trp . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
128,
131
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
136,
139
]
} |
the synthesis and biological activity of some novel analogs of the calcium channel blocker nifedipine , i.e. , derivatives of 2.6-dimethyl-3.5-diethoxycarbonyl-4- ( 3-nitrophenyl ) -1.4-dihydropyridine ( dhp ) were studied . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
91,
101
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
186,
201
]
} |
some new opiate-like peptides originating from opioid peptide precursors , dinorphine , histone h2b , major myeline protein , natriuretic atriopeptide and from the immunomodulating protein splenin whose primary structure differs essentially from that of enkephalins are described . | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
47,
61
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
254,
265
]
} |
in the series of selectivity of bilayer membranes for cations of alkaline metals the rubidium ion is before the cesium ion . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
54,
61
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
119,
122
]
} |
this is the only difference between this series and the series of relative ionic mobility series of cations of alkaline metals in water solutions . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
75,
80
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
100,
107
]
} |
corticosteroids augmented the lung volumes of surfactant-treated lungs more than did t3 , and no additive effects on lungs treated with both hormones and surfactant were noted . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
0,
15
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
141,
149
]
} |
while t3 did not alter the increase in lung volumes noted with corticosteroids , lung structure as assessed by lung rupture was differentially affected by the two hormones . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
63,
78
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
163,
171
]
} |
the same effects could be achieved by daily s.c. injections of prolactin ( 100 micrograms ovine-prl/day ) into hypophysectomized hamsters , whereas the injection of adrenocorticopropic hormone ( 5 iu porcine-acth/day ) or melanocyte-stimulating hormone ( 35 micrograms synthetic alpha-msh/day ) was ineffective . | NA | {
"id": "C0026667",
"name": "melanocyte-stimulating",
"pos": [
222,
244
]
} | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
279,
288
]
} |
the acute phase reactants , fibrinogen and alpha 2-antiplasmin in rat plasma , were altered little if any two to 24 hours after injection of 250,000 u/kg tnf . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
4,
25
]
} | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
28,
38
]
} |
only some of the gpiiia moabs reacted with cells other than platelets , megakaryocytes , or hel cells , and these showed focal adhesion sites in cultured human endothelial cells , fibroblasts , and epithelial cells from normal kidney tubules . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
180,
191
]
} |
they did not react , however , with transformed fibroblasts , fibrosarcoma cells , cultured cells from hypernephromas , or cultured human amnion epithelial cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
156,
161
]
} |
alanine-382 , 12 residues from the reactive center , is a highly conserved amino acid in the family of serine protease inhibitors known as the serpins . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
75,
85
]
} |
the monoclonal antibody 6d1 , directed against the von willebrand factor binding site on gpib , has no effect on plasminogen-platelet binding , nor does antithrombospondin antibody . epsilon-aminocaproic acid ( eaca ) , however , inhibits plasminogen binding to adp-activated platelets . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
4,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
172,
180
]
} |
the normal myeloid hematopoietic regulatory proteins include four growth-inducing proteins called colony-stimulating factors ( csf ) , including interleukin-3 ( il-3 ) , or macrophage and granulocyte inducers , type 1 ( mgi-1 ) , and another type of protein ( mgi-2 ) with no myeloid cell growth-inducing activity that induces differentiation of normal myeloid precursor cells and certain clones of myeloid leukemic cells . | NA | {
"id": "C0009392",
"name": "colony-stimulating factors",
"pos": [
98,
124
]
} | {
"id": "C0021757",
"name": "interleukin-3",
"pos": [
145,
158
]
} |
the anti-mgi-2 antibody did not inhibit the activity of any one of the four myeloid growth-inducing proteins ( csf or il-3 = mgi-1 ) , il-1 , tumor necrosis factor , or lymphotoxin . | NA | {
"id": "C0009392",
"name": "csf",
"pos": [
111,
114
]
} | {
"id": "C0021757",
"name": "il-3",
"pos": [
118,
122
]
} |
these different types include four growth-inducing proteins called colony-stimulating factors ( csf ) , including interleukin-3 ( il-3 ) , or macrophage and granulocyte inducers , type 1 ( mgi-1 ) ; | NA | {
"id": "C0009392",
"name": "colony-stimulating factors",
"pos": [
67,
93
]
} | {
"id": "C0021757",
"name": "interleukin-3",
"pos": [
114,
127
]
} |
we have now studied the ability of cyclosporine a and recombinant il-1 alpha to regulate in vivo differentiation of different clones of myeloid leukemic cells that are either susceptible or resistant to induction of differentiation by il-1 in vitro . | NA | {
"id": "C0600251",
"name": "recombinant il-1 alpha",
"pos": [
54,
76
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
235,
239
]
} |
( b ) recombinant il-1 alpha induced in vivo terminal differentiation of il-1-sensitive but not il-1-resistant clones of myeloid leukemic cells ; | NA | {
"id": "C0600251",
"name": "recombinant il-1 alpha",
"pos": [
6,
28
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
96,
100
]
} |
( c ) il-1 alpha and gm-csf synergistically induced differentiation in vivo in a gm-csf-responsive and il-1-nonresponsive clone of leukemic cells ; | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
6,
16
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
103,
107
]
} |
we conclude that the thrombolytic efficacy of streptokinase reflects not only the nature of the plasminogen activator complex but also the function of the proteinase inhibitors . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
46,
59
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
96,
117
]
} |
furthermore , receptor-mediated endocytosis is quantitatively blocked by preincubation of neonatal rbcs with sodium cyanide , whereas cyanide does not inhibit drug-induced endocytosis in either adult or neonatal rbcs . | NA | {
"id": "C0037498",
"name": "sodium cyanide",
"pos": [
109,
123
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
134,
141
]
} |
analysis of immunoglobulin ( ig ) and t-cell receptor-beta ( tcr beta ) gene rearrangements from serial peripheral blood mononuclear cell specimens ( mncs ) confirmed not only the b-cell nature of the disease , but also the subsequent emergence of a morphologically indistinguishable population of cells with a clonal tcr beta rearrangement in addition to the original ig gene rearrangement . | NA | {
"id": "C1321301",
"name": "cell",
"pos": [
40,
44
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
356,
359
]
} |
a comparison of phospholipid and platelets in the activation of human factor viii by thrombin and factor xa , and in the activation of factor x . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
98,
107
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
135,
143
]
} |
two aspects of the activation of factor x by the intrinsic clotting pathway have been studied in purified human systems , in the presence of either purified phosphatidylserine : phosphatidylcholine vesicles ( ps : pc ) or platelets activated with ionophore a23187 : ( 1 ) the activation of factor viii by factor xa and by thrombin , and ( 2 ) the activation of factor x by the factor ixa/viiia complex . | NA | {
"id": "C0015506",
"name": "factor viii",
"pos": [
290,
301
]
} | {
"id": "C0015514",
"name": "factor",
"pos": [
377,
383
]
} |
two aspects of the activation of factor x by the intrinsic clotting pathway have been studied in purified human systems , in the presence of either purified phosphatidylserine : phosphatidylcholine vesicles ( ps : pc ) or platelets activated with ionophore a23187 : ( 1 ) the activation of factor viii by factor xa and by thrombin , and ( 2 ) the activation of factor x by the factor ixa/viiia complex . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
305,
314
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
361,
369
]
} |
the products of optimal factor viii activation by the two enzymes , designated factor viiia ( t ) and factor viiia ( xa ) , are kinetically different in the activation of factor x by factor ixa , factor viiia ( t ) being approximately twice as active ( in factor x activation ) as factor viiia ( xa ) in the presence of ps : pc or platelets . | NA | {
"id": "C0015506",
"name": "products",
"pos": [
4,
12
]
} | {
"id": "C0015514",
"name": "factor viiia",
"pos": [
281,
293
]
} |
a comparison between the sequences of the normal dna surrounding the 3 ' breakpoint and the normal dna surrounding the 5 ' breakpoint shows that deletion is the result of a nonhomologous recombination event . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
99,
102
]
} |
these results are discussed in terms of the mechanism generating large deletions in mammalian cells and three models for the regulation of gamma-globin and beta-globin gene expression in humans . | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
139,
151
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
156,
167
]
} |
the data indicated that the bacteria adhered to the acac , but that the charcoal was not bactericidal . | NA | {
"id": "C0001275",
"name": "acac",
"pos": [
52,
56
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
72,
80
]
} |
adenocarcinomas represented 40 % of the cases , lymphomas 20 % , carcinoid tumours 20 % , sarcomas 17 % and undifferentiated carcinomas 2 % . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
0,
15
]
} | {
"id": "C0007095",
"name": "carcinoid tumours",
"pos": [
65,
82
]
} |
the tachykinin antagonist ( d-arg1 , d-cl2phe5 , asn6 , d-trp7.9 , nle11 ) -substance p , injected intravenously , blocked salivary secretion from the ferret parotid and submandibular glands in response to subsequent i.v . injections of the tachykinins , substance p and neurokinin a . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
241,
252
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
255,
266
]
} |
the tachykinin antagonist ( d-arg1 , d-cl2phe5 , asn6 , d-trp7.9 , nle11 ) -substance p , injected intravenously , blocked salivary secretion from the ferret parotid and submandibular glands in response to subsequent i.v . injections of the tachykinins , substance p and neurokinin a . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
241,
252
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
271,
283
]
} |
the ontogenesis of mu- and delta-opioid binding sites was studied using rat whole brain membranes and [ 3h ] - [ d-ala2mephe4-gly-ol ] enkephalin and [ 3h ] - [ d-pen2 , d-pen5 ] enkephalin as binding ligands . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
135,
145
]
} | {
"id": "C0525856",
"name": "d-pen2 , d-pen5 ] enkephalin",
"pos": [
161,
189
]
} |
the proposal that adenosine 5'-monophosphate ( amp ) can be used as a selective antagonist of atp at p2-purinoceptors on smooth muscle was investigated by examining the electrical and mechanical responses of guinea-pig and rat vasa deferentia to stimulation of sympathetic nerves and to exposure to exogenous agonists . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
18,
29
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
94,
97
]
} |
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