text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the contractile responses of the guinea-pig vas deferens to exogenously applied adenosine 5'-triphosphate ( atp ) were not reduced by amp , even at a concentration of 2.5 x 10 ( -4 ) m . | NA | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
80,
91
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
134,
137
]
} |
in two patients with large acoustic neuromas and a cyst , the true relationship of the cyst to the tumour could only be identified on the post-gd-dtpa scan . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
51,
55
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
99,
105
]
} |
low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
0,
28
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
98,
105
]
} |
the chorea produced by lateral pallidal or medial putaminal injections was virtually indistinguishable from the dyskinesia ( chorea/ballism ) which has been shown , in previous studies , to be induced by injection of gaba antagonists into the subthalamic nucleus . | NA | {
"id": "C0008489",
"name": "chorea",
"pos": [
4,
10
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
112,
122
]
} |
since this also occurs in huntington 's disease , it is proposed that experimental chorea induced by this method in the monkey may be a useful model of the dyskinesia seen in huntington 's disease in man . | NA | {
"id": "C0008489",
"name": "chorea",
"pos": [
83,
89
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
156,
166
]
} |
we have studied the modulatory actions of two members of the tachykinin family ( neurokinin a and b ) on endogenous catecholamine ( ca ) secretion from cultured adrenal chromaffin cells . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
61,
71
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
81,
93
]
} |
similarly , in estrogen-primed females but not males , progesterone induced a presurge sequential accumulation and decline of lh-releasing hormone ( lh-rh ) concentrations in the median eminence and increased the turnover rates of norepinephrine ( ne ) and epinephrine ( e ) in the medial basal hypothalamus during the time of lh-rh accumulation . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
231,
245
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
257,
268
]
} |
influence of gaba , baclofen and bicuculline on the extracellular k+ activity in the olfactory bulb of the developing rat . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
13,
17
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
20,
28
]
} |
gamma-aminobutyric acid ( gaba ) and baclofen were iontophoresed into the glomerular and plexiform layers of the olfactory bulb of rats at different ages . | NA | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
0,
23
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
37,
45
]
} |
furthermore , [ 203hg ] mehg uptake at 15 s after intracarotid injections in the rat was stereospecific to the neutral amino acid carrier , as 203hg uptake across the bbb was not inhibited by coinjections of [ 203hg ] mehgcl with aspartic acid , an acidic amino acid . | NA | {
"id": "C0004015",
"name": "aspartic acid",
"pos": [
230,
243
]
} | {
"id": "C0815040",
"name": "acidic amino acid",
"pos": [
249,
266
]
} |
absorption of tau antisera with tau and phf and of phf antisera with phf resulted in complete removal of the tangles-staining antibodies . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
18,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
126,
136
]
} |
these intermediate filament protein bands on western blots were characterized as 3 cytokeratin-like proteins ( 49 , 55 , and 58 kda ) , one vimentin-like protein ( 53 kda ) , two distinct glial fibrillary acidic protein ( gfap ) -like proteins ( 60 and 67 kda ) , and 3 neurofilament proteins ( 73 , 175 , and 200 kda ) by evaluation of their crossreactivities with specific antibodies directed against the mammalian forms of these proteins . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
6,
18
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
140,
148
]
} |
these intermediate filament protein bands on western blots were characterized as 3 cytokeratin-like proteins ( 49 , 55 , and 58 kda ) , one vimentin-like protein ( 53 kda ) , two distinct glial fibrillary acidic protein ( gfap ) -like proteins ( 60 and 67 kda ) , and 3 neurofilament proteins ( 73 , 175 , and 200 kda ) by evaluation of their crossreactivities with specific antibodies directed against the mammalian forms of these proteins . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
6,
18
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic protein",
"pos": [
188,
219
]
} |
these intermediate filament protein bands on western blots were characterized as 3 cytokeratin-like proteins ( 49 , 55 , and 58 kda ) , one vimentin-like protein ( 53 kda ) , two distinct glial fibrillary acidic protein ( gfap ) -like proteins ( 60 and 67 kda ) , and 3 neurofilament proteins ( 73 , 175 , and 200 kda ) by evaluation of their crossreactivities with specific antibodies directed against the mammalian forms of these proteins . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
6,
18
]
} | {
"id": "C0085418",
"name": "neurofilament proteins",
"pos": [
270,
292
]
} |
single cell suspensions of early postnatal mouse cerebellum adhere to substrate-bound culture supernatants of the teratocarcinoma cell line pf-hr9 and can be inhibited to adhere by antibodies to the neural cell adhesion molecules l1 and n-cam . | NA | {
"id": "C0950625",
"name": "neural cell adhesion molecules",
"pos": [
199,
229
]
} | {
"id": "C0282587",
"name": "n-cam",
"pos": [
237,
242
]
} |
these experiments show for the first time that extracellular matrix constituents can act as binding partners for the neural cell adhesion molecules l1 and n-cam . | NA | {
"id": "C0950625",
"name": "neural cell adhesion molecules",
"pos": [
117,
147
]
} | {
"id": "C0282587",
"name": "n-cam",
"pos": [
155,
160
]
} |
the antitumoral activity and toxicity of a new daunorubicin analog ( 4-demethoxydaunorubicin , imi 30 , idarubicin ) was tested in 20 consecutive patients with non-small cell lung cancer mostly pretreated with chemotherapy . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
47,
59
]
} | {
"id": "C0020789",
"name": "idarubicin",
"pos": [
104,
114
]
} |
it was concluded that the metabolic , enzymes , sarcoplasmic reticulum ca2+-atpase and myosin isozymes have different sensitivities to thyroid treatment and that minor thyroid treatments do result in significant changes in the biochemical character of the myocardium . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
38,
45
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
94,
102
]
} |
in fact low levels of high density lipoprotein ( hdl ) cholesterol are as much a risk factor for cad as high ldl cholesterol . | NA | {
"id": "C0023824",
"name": "in",
"pos": [
0,
2
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
113,
124
]
} |
addition of norepinephrine , epinephrine , phenylephrine , methoxamine , or clonidine to the bath caused contractions in all arteries . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
12,
26
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
29,
40
]
} |
thus , ( i ) varying the source of omega 3-fatty acids ( vegetable , 18:3 omega 3 versus fish oil , 20:5 omega 3 ) altered the mucosal mass of the intestine , and ( ii ) the source of the dietary omega 3-fatty acid ( 18:3 omega 3 versus 20:5 omega 3 ) influenced intestinal hexose uptake , with fish oil having an anti-absorptive effect on the jejunal uptake of d-glucose . | NA | {
"id": "C0015689",
"name": "omega 3",
"pos": [
35,
42
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
295,
303
]
} |
ifosfamide has given similar results and may have greater potential in combination therapy than cyclophosphamide . | NA | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
0,
10
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
96,
112
]
} |
the distribution of nhl by histologic type was : follicular center cell lymphomas ( fccl ) 39 % , small lymphocytic lymphoma ( sll ) 33 % , immunoblastic lymphoma ( ibl ) 17 % , and plasmacytoid lymphocytic lymphoma ( pll ) 11 % . | NA | {
"id": "C0024305",
"name": "nhl",
"pos": [
20,
23
]
} | {
"id": "C0024301",
"name": "follicular center",
"pos": [
49,
66
]
} |
the distribution of nhl by histologic type was : follicular center cell lymphomas ( fccl ) 39 % , small lymphocytic lymphoma ( sll ) 33 % , immunoblastic lymphoma ( ibl ) 17 % , and plasmacytoid lymphocytic lymphoma ( pll ) 11 % . | NA | {
"id": "C0024305",
"name": "nhl",
"pos": [
20,
23
]
} | {
"id": "C0079746",
"name": "immunoblastic",
"pos": [
140,
153
]
} |
they were elongate , fibroblast-like , appearing cells containing mitochondria , endoplasmic reticulum , golgi complexes , filaments and microtubules . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
21,
31
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} |
non-sulphate ( high iron diamine-negative , dialysed colloidal iron-positive ) anionic sites have been identified not only in the glycocalyx of the epithelial and endothelial cells but also in the laminae rarae of the basement membranes , where they show a more extensive distribution pattern than sulphate sites . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
79,
86
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
298,
306
]
} |
the high levels of n-nitroso compounds present in zarda tobacco indicate that zarda chewing communities are exposed to a considerable exogenic burden of potentially carcinogenic compounds , in particular tsna . | NA | {
"id": "C0028199",
"name": "nitroso compounds",
"pos": [
21,
38
]
} | {
"id": "C0028197",
"name": "tsna",
"pos": [
204,
208
]
} |
since the mel cells accumulate high levels of both hemoglobin-bound and non-hemoglobin-bound heme , the effect of both hemoglobin and hemin on dna ligase activity of mel cell extracts was tested . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
93,
97
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
134,
139
]
} |
the purpose of this report was to investigate the binding specificities and ability to generate antibody dependent cell mediated cytotoxicity ( adcc ) or antibody dependent complement mediated cytotoxicity of three novel monoclonal antibodies ( mabs ) , designated m74 , m77 , and m79 , raised against the colorectal carcinoma antigen 17-1a . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
96,
104
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
221,
231
]
} |
the diploid fibroblasts as well as a simian virus 40-transformed cell line are hypersensitive to killing by many dna-damaging agents , exhibit a slightly increased level of spontaneous sister chromatid exchange , and show a defect in dna ligation in vivo . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
113,
116
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
241,
242
]
} |
tpa treatment produced peak elevations in epidermal putrescine levels at 6 h and epidermal spermidine levels at 24 h after a single treatment . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
52,
62
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
102,
108
]
} |
a new dna precipitation assay used together with the alkali unwinding assay may provide a rapid means of detecting dna damage in addition to strand breaks based on the relative amount of damage measured by the two assays . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
6,
9
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
217,
218
]
} |
while quantification of specific lesions is not possible with this approach , the concomitant use of these two assays may provide a rapid and simple method for screening genotoxic drugs for dna damage , and may also help to differentiate between dna lesions which include strand breaks , interstrand and protein cross-links , dna-phosphate adducts , and dna-drug precipitates . | NA | {
"id": "C0242958",
"name": "dna",
"pos": [
190,
193
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
354,
357
]
} |
biochemical and immunological comparison of mouse c3h 10t 1/2 fibroblasts and c3h 10t 1/2 fibroblasts transfected with human activated ha-ras oncogene indicated significantly lower levels of protein kinase c ( pkc ) activity and protein in the ras-transfected cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
260,
265
]
} |
in situ hybridization demonstrated that the relatively high nm23 rna levels in low metastatic ras + ela-cotransfected ref cells were not due to overexpression of the nm23 gene by a subpopulation of cells . | NA | {
"id": "C0016030",
"name": "ref",
"pos": [
118,
121
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
198,
203
]
} |
the 1c5-defined antigen was resistant to neuraminidase and trypsin treatment , but sensitive to periodate treatment , indicating that an epitope of the 1c5-defined antigen is a carbohydrate moiety . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
137,
144
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
164,
171
]
} |
the total plasminogen activator ( pa ) activity and the activities of urokinase type ( upa ) and tissue type ( tpa ) plasminogen activators were measured in 43 primary human breast cancer homogenates . | NA | {
"id": "C0032143",
"name": "tpa",
"pos": [
111,
114
]
} | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
117,
139
]
} |
cells with this phenotype were only found in one of nine low grade non-hodgkin 's lymphoma samples ( l-nhl , 1/9 ) . | NA | {
"id": "C0079747",
"name": "low grade",
"pos": [
57,
66
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
103,
106
]
} |
lectin binding , biolabeling , and deglycosylation experiments demonstrate that it contains o-linked carbohydrate side chains with sialic acid and hexoses including fucose , galactose , and/or galactosamine but little if any mannose . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
147,
154
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
174,
183
]
} |
lectin binding , biolabeling , and deglycosylation experiments demonstrate that it contains o-linked carbohydrate side chains with sialic acid and hexoses including fucose , galactose , and/or galactosamine but little if any mannose . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
147,
154
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
225,
232
]
} |
compared to the sensitive cell line ( glc4 ) , the glc4-cddp showed an increase in doubling time and a decrease in cloning efficiency , cellular size , double minutes per cell , cellular protein , and nuclear protein content . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
187,
194
]
} | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
201,
216
]
} |
macrophage and lymphocyte potentiation of syngeneic tumor cell and host fibroblast collagenolytic activity in rats . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
58,
62
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
72,
82
]
} |
incubation of the two fibroblast populations with lym-cm produced a 10- and 7-fold stimulation of collagenolytic activity by nrs-f and ln3-f cells , respectively . | NA | {
"id": "C0016030",
"name": "nrs-f",
"pos": [
125,
130
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} |
incubation of tumor-associated ln3-f or nrs-f fibroblasts with mtln2 tumor cell-conditioned medium enhanced fibroblast collagenolytic activity approximately 20 and 17 times , respectively . | NA | {
"id": "C0007634",
"name": "nrs-f",
"pos": [
40,
45
]
} | {
"id": "C0016030",
"name": "nrs-f",
"pos": [
40,
45
]
} |
native chromosomal structure , breakage , and overall degradation were studied following the reaction of whole cells with the anticancer drug bleomycin and structurally related phleomycin . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
142,
151
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
177,
187
]
} |
electrophoretic analyses of cellular dna established that phleomycin was more reactive with dna than equimolar bleomycin in the range of 0.67-33 x 10 ( -6 ) m , produced an optimally visible , though less-extended , oligonucleosomal series at concentrations 12 to 35 times lower than bleomycin , and degraded dna within nucleosomes . | NA | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
58,
68
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
284,
293
]
} |
chromosomes were cleaved into nucleosomes and degraded by phleomycin over substantially narrower dose ranges ( 1 to 2 x 10 ( -6 ) m ) than by bleomycin ( about 1 to 17 x 10 ( -5 ) m ) . | NA | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
58,
68
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
142,
151
]
} |
bleomycin exhibited higher specificity for internucleosomal cleavage than phleomycin , and trimmed but did not degrade nucleosomes at less than or equal to 3 x 10 ( -5 ) m . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
0,
9
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
74,
84
]
} |
the higher reactivity of phleomycin does not result solely from its higher rate of internucleosomal and intranucleosomal chromatin cleavage , since short phleomycin reactions always resulted in more extensive chromatin cleavage than long bleomycin reactions at low concentrations . | NA | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
25,
35
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
238,
247
]
} |
in vivo ( cellular ) repair of chromatin damage was comparable ( approximately 90 % in 1 h ) after cells were exposed to low drug concentrations which produced similar numbers of chromatin breaks , and thus also does not account for the higher chromosomal breakage caused by phleomycin than bleomycin at low doses . | NA | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
275,
285
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
291,
300
]
} |
at high doses , unrepaired breaks are substantially higher after phleomycin treatments than after bleomycin treatments , and thus contribute to the higher lethal effects of phleomycin than bleomycin . | NA | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
65,
75
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
189,
198
]
} |
while carcinogenesis is known to induce various alterations in epithelial cell polarity , little information is available about the fate of plasma membrane polarity during the neoplastic process . | NA | {
"id": "C0596263",
"name": "carcinogenesis",
"pos": [
6,
20
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
176,
194
]
} |
we have investigated the effects of phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) and permeant diacylglycerol 1,2-dioctanoyl-sn-glycerol ( dic8 ) on mcf-7 cell proliferation and protein kinase c activity . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
36,
49
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
50,
86
]
} |
in rats rendered overweight by insulin treatment , the d-f-induced decrease in bw was approximately four times smaller than in controls . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
17,
27
]
} | {
"id": "C0005910",
"name": "bw",
"pos": [
79,
81
]
} |
fenfluramine and norfenfluramine plasma levels have been used as probes to help detect and normalize these variances . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
0,
12
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
17,
32
]
} |
several findings suggest that d-fenfluramine and d-norfenfluramine cause anorexia by increasing the availability of serotonin at postsynaptic receptors . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
32,
44
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
51,
66
]
} |
some of the molecular consequences of this dual effect and its possible role in certain b-cell lymphoproliferative diseases such as multiple myeloma are discussed . | NA | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
95,
123
]
} | {
"id": "C0026764",
"name": "multiple myeloma",
"pos": [
132,
148
]
} |
however , the incidence of new hiv infections within the homosexual community is already slowing because of changing behavior after the advent of aids . | NA | {
"id": "C0019693",
"name": "hiv infections",
"pos": [
31,
45
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
146,
150
]
} |
the purpose of this study is to compare the clinical and laboratory findings at presentation of 38 intravenous drug abusers with pathologically documented persistent generalized lymphadenopathy and 50 patients with biopsy proven malignant lymphoma ( 30 hodgkin diseases , 20 non-hodgkin 's lymphomas ) not related to acquired immunodeficiency syndrome , all aged 40 years or less and consecutively seen and evaluated with a similar clinicopathological approach since may 1984 in a single institution , centro di riferimento oncologico , aviano , italy . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
229,
247
]
} | {
"id": "C0019829",
"name": "hodgkin diseases",
"pos": [
253,
269
]
} |
the purpose of this study is to compare the clinical and laboratory findings at presentation of 38 intravenous drug abusers with pathologically documented persistent generalized lymphadenopathy and 50 patients with biopsy proven malignant lymphoma ( 30 hodgkin diseases , 20 non-hodgkin 's lymphomas ) not related to acquired immunodeficiency syndrome , all aged 40 years or less and consecutively seen and evaluated with a similar clinicopathological approach since may 1984 in a single institution , centro di riferimento oncologico , aviano , italy . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
229,
247
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
275,
299
]
} |
in addition , lung cancer , testicular cancer , chronic lymphocytic leukemia , malignant melanoma , basal cell carcinoma , cervical cancer , and multiple myeloma have been recently reported in persons at risk for aids with hiv infection , with some peculiar clinicopathological features , including age , histological type , and clinical aggressiveness . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
213,
217
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
223,
236
]
} |
within the gicat ( gruppo italiano cooperativo aids & tumori ) framework , we have identified four cases of testicular cancer , two cases of leukemia , and 1 case each of cervical cancer , carcinoma of the oral cavity , lung cancer , brain tumor , and multiple myeloma in persons at risk for aids , mainly i.v . drug abusers , with hiv infection , diagnosed in different italian institutions . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
47,
51
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
332,
345
]
} |
although these data are preliminary and are not indicative of an actual increase in the incidence of malignancies other than malignant lymphomas and kaposi 's sarcoma in the aids setting , clinicians should be aware of the possible association of these tumors with hiv infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
174,
178
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
265,
278
]
} |
interleukin-2 ( il-2 ) is a chemically defined lymphokine ( lk ) available as mixed human ( lk ) preparations , as partially purified lymphoblastoid il-2 , or as recombinant human il-2 . | NA | {
"id": "C0021756",
"name": "il-2",
"pos": [
16,
20
]
} | {
"id": "C0218986",
"name": "recombinant human il-2",
"pos": [
162,
184
]
} |
the experiments described in this study examined responsiveness of peripheral blood lymphocyte mononuclear ( mnc ) cells , natural killer ( nk ) cells , t-helper ( thc ) cells , and nill ( cells obtained from patients with advanced breast cancer ) cells from 10 of each age-matched subjects from 10 healthy adults and patients , 10 with benign breast diseases ( bbd ) , and 10 from patients from each of the breast carcinoma pathological stage bca ps i , bca ps ii , bca ps iii , and bca ps iv . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
67,
83
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
248,
253
]
} |
to analyze further the nature of the effector cells operative in this system , peripheral blood lymphocytes from eight tcc patients were stimulated in vitro with tcc extract and cultured in the presence of interleukin 2 and allogeneic feeder cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
14,
17
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
224,
234
]
} |
the blood kinetics and tissue distribution of a conjugate of daunomycin and a monoclonal antibody ( 791t/36 ) have been examined in mice , including nude mice with human tumour xenografts reactive with the antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
78,
97
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
206,
214
]
} |
three synthetic glycolipids , maltose tetrapalmitate ( mtp ) , maltose hexastearate ( mhs ) , and maltose hexalinoleate ( mhl ) prepared as nontoxic lipid a analogs , and escherichia coli lipopolysaccharide ( lps ) were assayed for their mitogenic activity using spleen lymphocytes in nine inbred mouse strains and three f1 hybrids . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
149,
156
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
188,
206
]
} |
ultrastructure , growth , and adherence to hydroxyapatite of streptococcus mutans atcc 27351 was studied after treating bacterial suspensions for 1 h with 0.1 % chlorhexidine gluconate ( chx ) , 0.1 % sodium fluoride ( f ) , or a combination of these two ( chx + f ) . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
201,
216
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
263,
264
]
} |
the total fluoride concentration in unstimulated whole saliva was measured before and at selected intervals after a self-applied 1.1 % neutral naf topical fluoride gel or use of a 0.05 % neutral naf fluoride mouthrinse in both normal individuals and patients with radiation-induced xerostomia . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
143,
146
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
199,
207
]
} |
the presence of phenol oxidase ( tyrosinase ) was used to reveal externally invisible or faintly visible melanophores by applying an excess of 3,4 dihydroxy-phenylalanine ( dopa ) . | NA | {
"id": "C0041484",
"name": "phenol oxidase",
"pos": [
16,
30
]
} | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
33,
43
]
} |
l428 cells did not produce detectable il-1 following stimulation with lipopolysaccharide or phorbol ester ( pma ) , nor did they transcribe detectable levels of mrna for il-1 alpha or beta after such treatment . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
38,
42
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
170,
180
]
} |
l428 cells did not produce detectable il-1 following stimulation with lipopolysaccharide or phorbol ester ( pma ) , nor did they transcribe detectable levels of mrna for il-1 alpha or beta after such treatment . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
92,
105
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
108,
111
]
} |
when cultured with dnp-labeled i-a+ cells , lyt 2+ t suppressor cells ( ts ) from 2,4 , -dinitrobenzene sulfonate ( dnbs ) -tolerized mice are activated to synthesize and release a suppressor factor ( ssf ) which suppresses the transfer of contact sensitivity to dnfb . | NA | {
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
89,
103
]
} | {
"id": "C0012463",
"name": "dnfb",
"pos": [
263,
267
]
} |
when albumin was replaced by a dextran polymer ( mr = 2 x 10 ( 6 ) ) used as a carrier of lipids instead of albumin ( which resulted in a serum-free and protein-free medium , spfm ) , the cell number was 75 % of that observed with the sfm-s . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
5,
12
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
153,
160
]
} |
dissociation of gelsolin bound on filament ends occurs in the presence of the polyphosphoinositides , pip and pip2 . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
78,
99
]
} | {
"id": "C0070798",
"name": "pip2",
"pos": [
110,
114
]
} |
the in-vitro activity of three long-acting cephalosporins ( cefotetan , cefonicid and ceftriaxone ) was compared against 206 clinical isolates of bacteroides fragilis , peptostreptococcus species and clostridium perfringens , using an agar dilution procedure to determine minimum inhibitory concentrations ( mics ) . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
43,
57
]
} | {
"id": "C0007551",
"name": "cefonicid",
"pos": [
72,
81
]
} |
cefotetan and latamoxef were the most active of the four cephamycins tested and all were stable to the beta-lactamases produced by these strains . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
57,
68
]
} |
cefotetan is a broad spectrum cephamycin antibiotic with a long serum half-life ( 3-4.5 h ) : this is explained , in part , by serum-protein-binding ( spb ) of 88 % . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
30,
40
]
} |
modulation of natural killer activity by 12-o-tetradecanoylphorbol-13-acetate and benzoyl peroxide in phorbol ester-sensitive ( sencar ) and resistant ( b6c3f1 ) mice . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
41,
77
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
102,
115
]
} |
following two weeks of topical application of 12-o-tetradecanoylphorbol-13-acetate ( tpa ) at 2 , 4 and 8 micrograms/mouse on alternate days ( 7x total ) or benzoyl peroxide ( bzp ) at 10 , 20 and 40 mg/mouse , natural killer ( nk ) activity was determined in local ( lymph nodes draining the lower dorsal region ) and systemic ( spleen ) lymphoid tissue in phorbol ester-sensitive ( sencar ) and resistant ( b6c3f1 ) mice . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
46,
82
]
} | {
"id": "C0031586",
"name": "phorbol",
"pos": [
358,
365
]
} |
growth of established murine tumor lines in media containing the phorbol ester tumor promoter 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , was associated with reversible reductions in sensitivity to in vitro and in vivo parameters of natural resistance . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
65,
78
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
94,
130
]
} |
while the significance of this particular adduct is not known , its formation suggests that the sulfur trioxide radical anion generated during the peroxidase-catalyzed oxidation of ( bi ) sulfite could react with a wide assortment of compounds to form sulfonate adducts . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
120,
125
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
188,
195
]
} |
in 1977 kakunaga reported the carcinogen-induced transformation of the diploid human fibroblast cell line kd into focus-forming , morphologically altered cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
85,
95
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
additional rflp analysis , using a probe made from m13 bacteriophage dna which detects a hyperpolymorphic 'minisatellite ' pattern in human dna , also showed that dna from hut-14 cells and from 8387 cells exhibit identical banding patterns , indicating that the cell lines were taken from the same individual . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
163,
166
]
} |
when a series of nucleotides was tested , only gtp , the non-hydrolysable analog gtp gamma s , dgtp and gdp were capable of significant activation at 1 microm , while other derivatives including gmp , atp and ctp were less effective . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
47,
50
]
} | {
"id": "C0079469",
"name": "gtp",
"pos": [
96,
99
]
} |
when myocardial phosphoinositides were prelabeled with [ 3h ] inositol , reperfusion after 30 minutes of normothermic global ischemia resulted in significant accumulations of radiolabeled inositol phosphate , inositol bisphosphate , and inositol trisphosphate . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
188,
206
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
237,
245
]
} |
atherosclerotic coronary artery disease is the major cause of late cardiac transplant failure secondary to silent ischemia and infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
114,
122
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
127,
137
]
} |
the monoclonal antibody was developed against liver prolidase and the antibody recognized the erythrocyte enzyme . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
4,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
70,
78
]
} |
heating of the serum at 56 degrees c induced an irreversible gel formation or pyroglobulin that was isolated and proved to be identical to the ige paraprotein , by biochemical and immunochemical methods . | NA | {
"id": "C0034305",
"name": "pyroglobulin",
"pos": [
78,
90
]
} | {
"id": "C0030490",
"name": "paraprotein",
"pos": [
147,
158
]
} |
it is speculated that distinct antigenic epitopes characteristic for untreated coeliac disease , might reside within a n-terminal repeat region of gliadin . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
31,
40
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
41,
49
]
} |
use of psa12-sphingomyelin permitted determination of sphingomyelinase activity in cell extracts ( eg human blood lymphocytes , lymphoid cell lines or cultured skin fibroblasts ) as well as in hair follicles and urine . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
83,
87
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
165,
176
]
} |
similarly , age , relative body weight , and resting plasma catecholamines were unrelated to the heart rate response to isoproterenol . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
60,
74
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
120,
133
]
} |
seven hypertensive patients receiving the dihydropyridine calcium channel blocking agent nicardipine were given placebo , 6.25 , 12.5 , 25 and 50 mg hydrochlorothiazide ( hctz ) in a randomized crossover design . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel",
"pos": [
42,
73
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
89,
100
]
} |
we propose that the latency of aids is not due to delayed viral expression and growth but rather to the accumulation of insults to an immune system with abnormal regulatory mechanisms induced by hiv infection of macrophages . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
31,
35
]
} | {
"id": "C0019693",
"name": "hiv",
"pos": [
195,
198
]
} |
antibodies which bind to these cross-reactive epitopes are common and are not restricted in isotype , affinity or species of origin . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
92,
99
]
} |
a 16-year-old saudi male with angiolymphoid hyperplasia and eosinophilia ( kimura 's disease ) for six years developed nephrotic syndrome . | NA | {
"id": "C0002989",
"name": "angiolymphoid hyperplasia",
"pos": [
30,
55
]
} | {
"id": "C0014457",
"name": "eosinophilia",
"pos": [
60,
72
]
} |
among children with asymptomatic hematuria , 28 cases of nonglomerular idiopathic renal bleeding were subjected to this series of study . | NA | {
"id": "C0018965",
"name": "hematuria",
"pos": [
33,
42
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
88,
96
]
} |
transperitoneal glucose absorption and the blood glucose and serum insulin response to the glucose load remain relatively unchanged with time . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
16,
23
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
43,
56
]
} |
inhibition of the bacterial degradation of an active antimicrobial is the basis of clavulanate and sulbactam-potentiated penicillin combinations , and inhibition of degradative pathways in the host is the rationale behind imipenem/cilastatin therapy . | NA | {
"id": "C0038665",
"name": "sulbactam",
"pos": [
99,
108
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
121,
131
]
} |
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