text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
time-dependent inhibition of bacterial beta-lactamases by clavulanic acid and sulbactam has extended the use of penicillins which are highly susceptible to beta-lactamase inactivation . | NA | {
"id": "C0038665",
"name": "sulbactam",
"pos": [
78,
87
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
112,
123
]
} |
digoxin interacts with other drugs at any stage of absorption ( e.g . cholestyramine ) , distribution ( e.g . quinidine ) , metabolism ( e.g . phenytoin ) or elimination ( e.g . diltiazem ) . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
124,
134
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
158,
169
]
} |
these observations indicate that both renal and metabolic elimination processes for theophylline are less active in the normal elderly . | NA | {
"id": "C0025519",
"name": "metabolic",
"pos": [
48,
57
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
58,
69
]
} |
the authors describe the ct findings in 10 cases of pulmonary aspergillosis which include allergic bronchopulmonary aspergillosis , aspergilloma and invasive pulmonary aspergillosis . | NA | {
"id": "C2350529",
"name": "pulmonary aspergillosis",
"pos": [
52,
75
]
} | {
"id": "C0276653",
"name": "invasive",
"pos": [
149,
157
]
} |
assay of von willebrand 's disease ( vwd ) plasmas with the elisa for vwf : ag demonstrated reduced levels of this antigen in type i vwd , normal levels in type iia , and a severe reduction of vwf : ag in type iii vwd . | NA | {
"id": "C0042974",
"name": "von willebrand 's disease",
"pos": [
9,
34
]
} | {
"id": "C1264041",
"name": "type",
"pos": [
205,
209
]
} |
fracture involving both the enamel and the dentine was the most commonly recorded class of trauma ( 42.7 % of cases ) . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
0,
8
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
91,
97
]
} |
trauma to the maxillary dental arch occurred most frequently at home , while trauma to more than one tooth ( multiple trauma ) occurred most commonly at school . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
0,
6
]
} | {
"id": "C0026771",
"name": "multiple",
"pos": [
109,
117
]
} |
following voltage activation of the passive cl- permeability of the mitochondria-rich ( m.r . ) cells sulfate flux-ratio increased to a value predicted from the ussing flux-ratio equation for a monovalent anion . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
102,
109
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
205,
210
]
} |
the effect of intraperitoneally administered gold thioglucose on growth , food consumption and accumulation of gold in various organs of the chicken ( gallus domesticus ) . | NA | {
"id": "C0018033",
"name": "gold thioglucose",
"pos": [
45,
61
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
111,
115
]
} |
gold detected in blood , heart , liver , gallbladder , spleen , proventriculus , gizzard , duodenum , kidney , pectoral muscle , small intestine , lung and brain of the dead chickens accumulated most highly in heart and followed by spleen , but in the surviving chicken a little gold was only found in liver , spleen and kidney of some gtg-treated chickens . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
0,
4
]
} | {
"id": "C0018033",
"name": "gtg",
"pos": [
336,
339
]
} |
hence , the inhibition of this rate may be an important function underlying the complement-mediated processing of immune complexes , and a decreased ability of the complement system to mediate this process in the presence of c4b1 , in contrast to c4a3 , could explain , at least in part , the association between the c4a-null phenotype and autoimmune diseases such as systemic lupus erythematosus . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
340,
359
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
368,
396
]
} |
maximal chemotaxis was achieved with a concentration of 5 ng/ml for limb bud cells and as low as 15 pg/ml for muscle-derived fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
77,
82
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
125,
136
]
} |
the binding of the lectins suggested that eep is composed of proteins having galactose or n-acetylgalactosamine groups as well as fucose residues . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
19,
26
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
61,
69
]
} |
chronological distribution of this intermediate filament-associated protein ( ifap ) and vimentin during fetal development of the cornea in rabbit was analysed immunohistochemically . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
35,
47
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
89,
97
]
} |
during an early stage of corneal development ( day 13 of gestation ) , both this ifap and vimentin were present in the stromal cells in the presumptive corneal region . | NA | {
"id": "C0021769",
"name": "ifap",
"pos": [
81,
85
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
90,
98
]
} |
at day 17 and 21 , the corneal endothelial layer was developed and contained both the ifap and vimentin . | NA | {
"id": "C0021769",
"name": "ifap",
"pos": [
86,
90
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
95,
103
]
} |
however , in the corneal stromal cells , the concentration of ifap ( based on the densities of the immunostaining reaction ) progressively decreased during the later stages of fetal development ( day 24 to day 28 ) , while relative concentrations of vimentin were not reduced significantly . | NA | {
"id": "C0021769",
"name": "ifap",
"pos": [
62,
66
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
250,
258
]
} |
in the corneal stromal cells in the adult rabbit , the ifap was not detectable while vimentin was still present . | NA | {
"id": "C0021769",
"name": "ifap",
"pos": [
55,
59
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
85,
93
]
} |
segregation of the x-linked mink markers alpha-galactosidase ( gla ) , phosphoglycerate kinase-1 ( pgk1 ) , hypoxanthine phosphoribosyltransferase ( hprt ) , and glucose-6-phosphate dehydrogenase ( g6pd ) was analyzed in hybrids of gamma-irradiated mink fibroblasts and chinese hamster cells and in hybrids of nonirradiated mink fibroblasts and mouse hepatoma cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
286,
291
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
329,
340
]
} |
both biochemical and genetic evidence therefore indicate independence of dbh from the pterin-dependent aromatic amino acid hydroxylases of the neurotransmitter pathways . | NA | {
"id": "C0013032",
"name": "dbh",
"pos": [
73,
76
]
} | {
"id": "C0020364",
"name": "hydroxylases",
"pos": [
123,
135
]
} |
autopsy showed enlarged heart , normal coronary arteries , right ventricular septal hypertrophy , quadricuspid pulmonary valve , accessory tricuspid valve , and a moderately elongated and thickened mitral valve . | NA | {
"id": "C0018800",
"name": "enlarged heart",
"pos": [
15,
29
]
} | {
"id": "C0162770",
"name": "right ventricular",
"pos": [
59,
76
]
} |
epac showed higher and longer-lasting erythromycin levels in serum , sputum and pure bronchial mucus than es . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
38,
50
]
} | {
"id": "C0059566",
"name": "es",
"pos": [
106,
108
]
} |
the isolates were tested against netilmicin , piperacillin , cefoxitin , cefuroxime , and cefotaxime , alone and in different combinations . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
73,
83
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
90,
100
]
} |
the in vitro activity of fleroxacin ( ro 23-6240 ) against 441 bacterial isolates was compared with those of ciprofloxacin , ofloxacin , amoxycillin , cefadroxil , cefuroxime and tobramycin . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
25,
35
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
109,
122
]
} |
ciprofloxacin showed the highest activity against the enterobacteriaceae , 95 % of the isolates were inhibited by 0.06 mg/l , but fleroxacin and ofloxacin were also highly active ( mic 90 % = 0.5 and 0.25 mg/l , respectively ) . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
0,
13
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
130,
140
]
} |
ciprofloxacin was the most active agent against pseudomonas aeruginosa ( mic 90 % = 0.12 mg/l ) , whereas the activities of fleroxacin and ofloxacin were more variable . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
0,
13
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
124,
134
]
} |
putrescine levels increased in the mononuclear cells of all patients , cellular spermidine levels increased in 4 and cellular spermine levels increased in 5 patients . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
0,
10
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
135,
141
]
} |
putrescine levels increased in the mononuclear cells of all patients , cellular spermidine levels increased in 4 and cellular spermine levels increased in 5 patients . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
11,
17
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
135,
141
]
} |
comparison of two cell lines such as friend murine erythroleukemia cells ( melc ) and fibroblasts fr3t3 cells has shown that this analysis can be used for cell-cycle characterization of a given cell line . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
67,
72
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} |
and 3 ) using the two antibodies ( mab b72.3 and mab anti-caa ) , a malignancy ratio was obtained that determined malignancy risk for individual polyps . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
22,
32
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
49,
52
]
} |
a diagnosis of turcot 's syndrome should be restricted to those patients with familial polyposis coli associated with gliomas or medulloblastomas . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
118,
125
]
} | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
129,
145
]
} |
solitary rectal ulcer syndrome ( srus ) is sufficiently uncommon that the clinician or general pathologist may lack familiarity with the disorder and may confuse it with other inflammatory bowel diseases . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
22,
30
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
137,
145
]
} |
the proximal small intestinal mucosa of rats fed lectin showed gradual increases in protein and dna contents throughout the experimental period . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
49,
55
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} |
in contrast , intravenous infusion of nahco3 ( 3 mmol/kg/hr ) ameliorated the acid-base imbalance caused by he , and significantly restored the impaired hco3- responses induced by he but not by indomethacin . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
38,
44
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
153,
157
]
} |
clinical expressions of hyperfunctional adrenocortical syndromes include cushing 's syndrome , primary hyperaldosteronism , and the adrenogenital syndrome . | NA | {
"id": "C0001622",
"name": "hyperfunctional adrenocortical",
"pos": [
24,
54
]
} | {
"id": "C0010481",
"name": "cushing 's",
"pos": [
73,
83
]
} |
2 ) maternal factor ( s ) affected cytochrome p-450-specific content and the activities of acetanilide hydroxylase and aryl hydrocarbon hydroxylase but not of testosterone 15 alpha- and 16 alpha-hydroxylases or nadph-cytochrome c reductase ; | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
35,
51
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
119,
147
]
} |
among the most prominent features of this interaction is the activation and high-level expression of the genes encoding the major myelin proteins p0 and myelin basic protein ( mbp ) . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
130,
145
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
153,
173
]
} |
bismuth intoxication ( encephalopathy ) has been reported with prolonged administration of bismuth salts , and there has been 1 report of similar intoxication in a patient receiving unusually high doses of cbs for a prolonged period . | NA | {
"id": "C0005642",
"name": "bismuth",
"pos": [
0,
7
]
} | {
"id": "C0106556",
"name": "cbs",
"pos": [
206,
209
]
} |
milrinone is a bipyridine derivative of amrinone , with approximately 10 to 75 times greater positive inotropic potency , and separate direct vasodilatory properties . | NA | {
"id": "C0128513",
"name": "milrinone",
"pos": [
0,
9
]
} | {
"id": "C0002697",
"name": "amrinone",
"pos": [
40,
48
]
} |
preliminary long term studies suggest that tolerance to the haemodynamic effects of milrinone does not occur , and that the drug is well tolerated and without the thrombocytopenic effects , fever and gastrointestinal complications observed with amrinone . | NA | {
"id": "C0128513",
"name": "milrinone",
"pos": [
84,
93
]
} | {
"id": "C0002697",
"name": "amrinone",
"pos": [
245,
253
]
} |
all of the fluoroquinolones except ofloxacin are associated with a variable increase in the serum concentration of theophylline , warfarin and caffeine . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
11,
27
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
35,
44
]
} |
[ hypercholesterolemia and the diagnosis and management of hyper- lipidemia in adults . recommendations of the working groups of the finnish society of internal medicine and the finnish cardiology society ] . | NA | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
2,
22
]
} | {
"id": "C0020473",
"name": "lipidemia",
"pos": [
66,
75
]
} |
the ultrastructure characteristics of leaves during the development of cell organelles , in the `` '' greening process '' '' of spring , have been studied in pollutant-tolerant and susceptible individuals of beech ( fagus silvatica ) and hornbeam ( carpinus betulus ) in an area polluted with so2 ( the main pollutant may reach 0.06-2.72 mg/m3 ) , heavy metals , and other gases discharged by non-iron metal processing factories . | NA | {
"id": "C0347988",
"name": ", heavy meta",
"pos": [
346,
358
]
} | {
"id": "C0302583",
"name": "n-ir",
"pos": [
395,
399
]
} |
when allowance was made for cytoplasmic na concentration , the pump rate was slower in younger ( 12 months and under ) normal children than in older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
126,
134
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
143,
157
]
} |
the accumulation of the two extracellular matrix proteins in the medium was differentially affected by fetal calf serum and tgf-beta and the increase was in both cases higher for tenascin . | NA | {
"id": "C0079323",
"name": "extracellular matrix",
"pos": [
28,
48
]
} | {
"id": "C0076088",
"name": "tenascin",
"pos": [
179,
187
]
} |
the rat m1 muscarinic receptor gene was cloned and expressed in a rat cell line lacking endogenous muscarinic receptors . | NA | {
"id": "C0531859",
"name": "m1",
"pos": [
8,
10
]
} | {
"id": "C0034826",
"name": "muscarinic receptors",
"pos": [
99,
119
]
} |
phorbol ester ( pma ) modulated the binding affinity of wild-type and mutant receptors in a similar manner . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
0,
7
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
16,
19
]
} |
despite the similarities shared by all lamin proteins , the lamin liii sequence neither possesses the features diagnostic for either type-a or type-b lamins nor does it show greater sequence similarity to one of the lamin types than to the other and thus it may represent a third type of lamin protein which may reflect its special function in oogenesis and early development . | NA | {
"id": "C0064635",
"name": "lamin",
"pos": [
39,
44
]
} | {
"id": "C0125258",
"name": "a",
"pos": [
359,
360
]
} |
the sequence gly-x-gly-lys-thr , believed to be involved in the interaction with purine nucleotides in proteins that bind and hydrolyze the nucleotides , is present in the rad3 primary structure between amino acids 45 and 49 . | NA | {
"id": "C0034137",
"name": "purine nucleotides",
"pos": [
81,
99
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
140,
151
]
} |
to demonstrate that the 3'-domain of rna c determines virulence , a chimeric satellite was constructed composed mostly of the 5'-domain of the avirulent satellite ( rna f ) and the 3'-domain of the virulent satellite ( rna c ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
37,
40
]
} | {
"id": "C0074081",
"name": "satellite",
"pos": [
207,
216
]
} |
between 2.5 % and 4.9 % of antibodies were obtained from two different anti-fibronectin sera indicating that this region represents an antigenic epitope in native fibronectin . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
135,
144
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
145,
152
]
} |
in the insulin-secreting beta cell line rin m 5f , galanin , a newly discovered ubiquitous neuropeptide , inhibited , by 50 % , the stimulation of insulin release induced by gastric inhibitory polypeptide ( gip ) or forskolin , i.e . two camp-generating effectors . | NA | {
"id": "C0060993",
"name": "galanin",
"pos": [
51,
58
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
91,
103
]
} |
by the identification of mannobiosido- , and mannotriosido-di-n-acetylchitobiose mixed with n-acetyl-lactosaminic and oligomannosidic-types oligosaccharides , we demonstrate the high microheterogeneity of the glycans presents in the neutral fraction of this glycoprotein and suggest that ovomucoid glycosylation uses several pathways . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
140,
156
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
209,
216
]
} |
gel-filtered human platelets that had been pre-labelled with [ 32p ] pi were stimulated with thrombin , ionomycin or the phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
121,
134
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol 13-acetate",
"pos": [
135,
172
]
} |
the in vitro activity of the new oral macrolide azithromycin was compared with that of erythromycin against gram-positive and gram-negative aerobic and anaerobic bacteria . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
48,
60
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
87,
99
]
} |
azithromycin was more active than erythromycin against haemophilus influenzae ( mic90 1 microgram/ml ) and neisseria gonorrhoeae . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
0,
12
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
34,
46
]
} |
susceptibility testing of clinical isolates of several gram-negative and gram-positive species showed ly163892 to be more active than cefaclor and cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
134,
142
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
147,
157
]
} |
in vitro activity of azithromycin and erythromycin against organisms associated with bacterial vaginosis and chancroid . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
21,
33
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
38,
50
]
} |
the in vitro activity of the new macrolide azithromycin and erythromycin against haemophilus ducreyi , gardnerella vaginalis , bacteroides spp . and mobiluncus spp . was compared . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
43,
55
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
60,
72
]
} |
collectively , 62 % of all bacteroides strains were susceptible to erythromycin ( mic 1 mg/1 ) and 74 % were susceptible to azithromycin . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
67,
79
]
} | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
124,
136
]
} |
the beta-lactams ( penicillin , ampicillin , cefoxitin and cephalexin ) , macrolides ( erythromycin and azithromycin ) , quinolones ( ciprofloxacin and ofloxacin ) , nitrofurans , gentamicin and tetracycline all had mic90 values of less than or equal to 0.5 mg/l . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
4,
16
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
19,
29
]
} |
the beta-lactams ( penicillin , ampicillin , cefoxitin and cephalexin ) , macrolides ( erythromycin and azithromycin ) , quinolones ( ciprofloxacin and ofloxacin ) , nitrofurans , gentamicin and tetracycline all had mic90 values of less than or equal to 0.5 mg/l . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
87,
99
]
} | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
104,
116
]
} |
antibodies against following peroxisomal enzymes : catalase , urate oxidase , alpha-hydroxy acid oxidase , acyl-coa oxidase , bifunctional enzyme ( hydratase-dehydrogenase ) and thiolase , were raised in rabbits , and their monospecificities were confirmed by immunoblotting . | NA | {
"id": "C0041931",
"name": "urate oxidase",
"pos": [
62,
75
]
} | {
"id": "C0030016",
"name": "dehydrogenase",
"pos": [
158,
171
]
} |
assuming carbohydrate-protein interactions play important physiological roles here , then specific carbohydrate-binding proteins should be prominent components of this microvasculature , in addition to the wealth of endogenous glycoconjugates reported by other authors . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
9,
21
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
227,
242
]
} |
platelet viability ( aggregation , migration , recovery ) after radiolabelling from hypercholesterolemics using various tracers ( oxine , oxine-sulphate , tropolone , mpo ) . | NA | {
"id": "C0000665",
"name": "oxine",
"pos": [
130,
135
]
} | {
"id": "C0086760",
"name": "oxine-sulphate",
"pos": [
138,
152
]
} |
a total of 100 patients receiving fluphenazine ( fpz ) decanoate for at least 12 months ( 96 schizophrenics and 4 other diagnoses ) were investigated for plasma levels of fpz and prolactin on the day of injection ( day 0 ) and 7 days later ( day 7 ) . | NA | {
"id": "C0060580",
"name": "fluphenazine",
"pos": [
34,
46
]
} | {
"id": "C0016368",
"name": "fpz",
"pos": [
171,
174
]
} |
adenosine 5'-monophosphate ( amp ) , adenosine 5'-diphosphate ( adp ) and adenosine 5'-triphosphate ( atp ) , injected intraperitoneally into tumor-bearing ( s.c. implanted footpad tumors ) mice , exhibited significant anticancer activity . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
0,
11
]
} | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
74,
85
]
} |
adenosine 5'-monophosphate ( amp ) , adenosine 5'-diphosphate ( adp ) and adenosine 5'-triphosphate ( atp ) , injected intraperitoneally into tumor-bearing ( s.c. implanted footpad tumors ) mice , exhibited significant anticancer activity . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
0,
11
]
} | {
"id": "C0001480",
"name": "adenosine",
"pos": [
74,
83
]
} |
intraperitoneal injections of 1 ml of 50 mm amp , adp or atp in saline , yielded elevated blood and plasma levels of atp which lasted for several hours in both strains of mice . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
44,
47
]
} | {
"id": "C0001459",
"name": "adp",
"pos": [
50,
53
]
} |
intraperitoneal injections of 1 ml of 50 mm amp , adp or atp in saline , yielded elevated blood and plasma levels of atp which lasted for several hours in both strains of mice . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
44,
47
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
117,
120
]
} |
the pharmacokinetics of disopyramide was studied in 15 patients with renal dysfunction ( 4 with pyelonephritis , 7 with glomerular nephritis and 4 with interstitial nephritis ) . | NA | {
"id": "C0034186",
"name": "pyelonephritis",
"pos": [
96,
110
]
} | {
"id": "C0027707",
"name": "interstitial nephritis",
"pos": [
152,
174
]
} |
the effects of optical isomers of fenfluramine and their metabolites , d- and l-norfenfluramine on the serotonergic system were studied in the nucleus accumbens and hippocampus of freely moving rats by in vivo voltammetry . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
34,
46
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
80,
95
]
} |
both isomers and the metabolites induced a slow , sustained decrease in 5hiaa but only d-fenfluramine and its metabolite , d-norfenfluramine , increased the 5hiaa levels in nucleus accumbens shortly after injection , the increase being greater after the metabolite . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
89,
101
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
125,
140
]
} |
intravenous injection of the synthetic trh analog , mk-771 , to anesthetised cats raised the blood pressure by a central mechanism , i.e . by activating the outflow of sympathetic stimuli from the cns to the periphery and raising the plasma concentration of adrenaline and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
258,
268
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
273,
286
]
} |
we find that the levels of each mrna analysed appear to cycle in the +/+ adult retina , with the greatest amount of opsin and the three subunits of g-protein mrnas occurring just before light onset and the greatest amount of 48-kda protein mrna occurring just before lights off . | NA | {
"id": "C0599220",
"name": "subunits",
"pos": [
136,
144
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
232,
239
]
} |
during the western blot analyses , the antiserum exhibited specific immuno-reaction with alpha-crystallin and 20-kda gamma-crystallin species and with degraded polypeptides among various human lens crystallins tested . | NA | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
89,
105
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
198,
209
]
} |
during the western blot analyses , the antiserum exhibited specific immuno-reaction with alpha-crystallin and 20-kda gamma-crystallin species and with degraded polypeptides among various human lens crystallins tested . | NA | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
117,
133
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
198,
209
]
} |
in order to examine the cellular basis of the low production of bpa by pha-stimulated cord blood mononuclear cells in the context of the functional immaturity of t cells or monocytes , we studied bpa production by t cells or monocytes from cord blood and adult peripheral blood . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
24,
32
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
91,
114
]
} |
there are two major hypotheses proposed to explain why adrenal medullary grafts may promote functional recovery in human parkinsonism : ( 1 ) replacement of lost striatal neurotransmitter ( dopamine ) by the viable grafted tissue , or ( 2 ) induction of recovery of remaining host dopaminergic systems by the implantation procedure . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
190,
198
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
281,
293
]
} |
we have used retrograde labeling with horseradish peroxidase ( hrp ) and a wheat germ agglutinin conjugate of hrp ( wga : hrp ) to investigate the projections of the nucleus postglomerulosus ( npg ) both in normal goldfish and in animals which had undergone retinal removal . | NA | {
"id": "C0078473",
"name": "wheat",
"pos": [
75,
80
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
122,
125
]
} |
sera from patients with other types of head and neck cancer and relatively high levels of igg antibody against viral capsid antigen ( vca ) and ea did not react reproducibly with any of the ebv-associated proteins . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
111,
116
]
} | {
"id": "C0003320",
"name": "ea",
"pos": [
156,
158
]
} |
retinoic acid regulates igg fc receptor expression in human myelomonocytic leukemia cells and normal peripheral monocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
84,
89
]
} | {
"id": "C1321301",
"name": "peripheral monocytes",
"pos": [
101,
121
]
} |
however , ra increased the percentage of ea rosetting promyelocytes of hl-60 and of patients with acute promyelocytic leukemia and a part of myeloblasts isolated from acute myelogenous leukemia patients . | NA | {
"id": "C0023487",
"name": "acute promyelocytic leukemia",
"pos": [
98,
126
]
} | {
"id": "C0023467",
"name": "acute myelogenous leukemia",
"pos": [
167,
193
]
} |
our results suggest that tp and long toxins recognize the neuromuscular nicotinic acetylcholine receptor ( achr ) and/or bind to the achr in a different mode than the short toxins do . | NA | {
"id": "C0034830",
"name": "nicotinic acetylcholine receptor",
"pos": [
72,
104
]
} | {
"id": "C0034792",
"name": "achr",
"pos": [
133,
137
]
} |
we previously established a human t cell line , tpa-mat , which can proliferate in response to not only interleukin-2 ( il-2 ) , but also phorbol esters such as 12-o-tetradecanoylphorbol-13-acetate ( tpa ) and phorbol-12,13-dibutyrate ( pdbu ) . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
138,
152
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
161,
197
]
} |
furthermore , whereas the accumulation of ip1 , ip2 and ip3 rapidly increased by as much as 125-175 % in chemotactic-factor-stimulated ams from healthy subjects , stimulation of cells from aas increased these inositol phosphates only slightly . | NA | {
"id": "C0021549",
"name": "ip3",
"pos": [
56,
59
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
209,
228
]
} |
our findings suggest that this dna-binding protein ( s ) may be a trans-acting factor in the regulation of the transcription of wheat histone genes . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
31,
50
]
} | {
"id": "C0040627",
"name": "trans-acting factor",
"pos": [
66,
85
]
} |
in the combined pge2/naproxen treatment the pge levels were significantly ( p less than 0.05 ) elevated in the ejaculate 48 hours after treatment . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
16,
20
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
44,
47
]
} |
among three dna polymerases , the level of dna polymerase beta activity well correlated with the histological findings ( johnsen 's score ) , i.e. , the extent of differentiation of germinal cells . | NA | {
"id": "C0012892",
"name": "dna polymerases",
"pos": [
12,
27
]
} | {
"id": "C0525039",
"name": "dna polymerase beta",
"pos": [
43,
62
]
} |
an increase in total phospholipids of lung extracts as well as that of separate fractions of phospholipids especially of phosphatidylcholine was revealed along with a direct interrelationship between the alveoli area and the phosphatidylcholine rate . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
21,
34
]
} | {
"id": "C0771648",
"name": "of",
"pos": [
118,
120
]
} |
the levels of hormones of the hypophysis ( acth , tth , cth ) , thyroid gland ( t3 , t4 ) , adrenal glands ( epinephrine , norepinephrine , cortisol ) and pancreas ( insulin , glucagon ) increased during a prolonged electrostimulation of the reticular nucleus of mesencephalon in rabbits . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
109,
120
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
123,
137
]
} |
to examine the mechanism of induction of differentiation in the human malignant t-lymphoblastic cell line , molt-3 , by 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , the role of receptors for phorbol esters was investigated . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
120,
156
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
193,
207
]
} |
the 7-ethoxyresorufin and 7-ethoxycoumarin deethylase , aryl hydrocarbon hydroxylase and cytochrome c-reductase activities were increased by benzo ( a ) pyrene in all the dietary groups . | NA | {
"id": "C0000644",
"name": "ethoxycoumarin deethylase",
"pos": [
28,
53
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
56,
84
]
} |
randomised trial comparing combinations of cyclophosphamide and cisplatin without or with doxorubicin or 4'-epi-doxorubicin in the treatment of advanced ovarian cancer . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
90,
101
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
105,
106
]
} |
to this end , porcine granulosa cells were incubated in monolayer culture for 1-4 days in the presence of fsh ( 200 ng/ml ) , forskolin ( 85 microm ) , or cholera toxin ( 3 micrograms/ml ) with or without an activator of protein kinase c , the phorbol ester 12-o-tetradecanoylphorbol 13-acetate ( tpa ) ( 30 ng/ml ) . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
244,
251
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
258,
294
]
} |
the immunofluorescence distribution of alpha- and beta-mhc isoproteins in newly isolated and cultured cardiomyocytes changed from 100 % alpha-mhc and 70 % beta-mhc in rod-shaped cells to about 100 % beta-mhc and 70 % alpha-mhc in spread out cultured cells . | NA | {
"id": "C0027100",
"name": "mhc",
"pos": [
55,
58
]
} | {
"id": "C0027096",
"name": "mhc",
"pos": [
223,
226
]
} |
in previous work , we found that the phorbol ester drug 12-o-tetradecanoyl phorbol acetate ( tpa ) reversed the developmental restriction of melanogenesis that normally occurs in neural crest-derived schwann cell precursors around embryonic day 5 of quail development . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
37,
50
]
} | {
"id": "C0039654",
"name": "tetradecanoyl",
"pos": [
61,
74
]
} |
according to the area and linearity of the tracks , the migratory behavior of the different cells can be classified into three groups : ( i ) fibroblasts and the nonpigmented bowes melanoma cells form straight and long tracks ; | NA | {
"id": "C0007634",
"name": "the",
"pos": [
13,
16
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
142,
153
]
} |
influence of camp and calcium on [ 3h ] inositol efflux , inositol phosphate accumulation , and insulin release from isolated rat islets . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
40,
48
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
58,
76
]
} |
all three stimulants increased the hydrolysis of inositol-containing phospholipids , an event monitored by an increase in [ 3h ] inositol efflux from [ 3h ] inositol-prelabeled islets and by the accumulation of labeled inositol phosphates . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
49,
57
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
219,
238
]
} |
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