text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
forskolin , despite its positive impact on insulin secretion , reduced [ 3h ] inositol efflux and inositol phosphate accumulation in response to all agonists . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
78,
86
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
98,
116
]
} |
to assess the role of counterregulatory hormones per se in the response to continuous insulin infusion , overnight-fasted dogs were given 5 mu.kg-1.min-1 insulin intraportally either alone ( ins , n = 5 ) , with glucose to maintain euglycemia ( ins + glu , n = 5 ) , or with glucose and hormone replacement [ i.e. , glucagon , epinephrine , norepinephrine , and cortisol infusions ( ins + glu + hr , n = 6 ) ] . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
327,
338
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
341,
355
]
} |
glucagon , epinephrine , norepinephrine , and cortisol were replaced in ins + glu + hr so that the increments in their levels were 102 +/- 6 , 106 +/- 14 , 117 +/- 9 , and 124 +/- 37 % , respectively , of their increments in ins . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
11,
22
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
25,
39
]
} |
because fish oil supplementation may favorably affect lipid and lipoprotein concentrations in nondiabetic subjects , we determined the effect of fish oil concentrate on plasma lipids and lipoprotein composition in patients with niddm . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
54,
59
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
187,
198
]
} |
dietary-supplementation 1-mo periods of 4.0 and 7.5 g of omega-3 fatty acids in fish oil were compared with a placebo of 12 g safflower oil by use of a single-blind crossover design . | NA | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
57,
76
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
80,
88
]
} |
the effects of ammonia and camp on prespore and prestalk differentiation of dictyostelium discoideum were investigated by monitoring eight developmentally regulated proteins as differentiation markers under the shake culture conditions in glucose/albumin medium . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
165,
173
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
247,
254
]
} |
this suggests that for the maintenance of the differentiated state after slug disaggregation camp may not be required with respect to the majority of proteins , if cells are provided with some favorable conditions such as glucose/albumin medium . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
150,
158
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
230,
237
]
} |
myosin extracted from tumours and electrophoresed on 6 % -sodium dodecyl sulfate ( sds ) glycerol gels was found to migrate as three distinct mhc components . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
0,
6
]
} | {
"id": "C0027100",
"name": "mhc",
"pos": [
142,
145
]
} |
calcium/calmodulin-dependent protein kinases are now believed to consist of at least five enzymes , which range from those with extreme substrate specificity such as phosphorylase kinase and myosin light-chain kinases to calcium calmodulin kinase ii , with several known substrates . | NA | {
"id": "C0006776",
"name": "calcium/calmodulin-dependent",
"pos": [
0,
28
]
} | {
"id": "C0027120",
"name": "myosin light-chain kinases",
"pos": [
191,
217
]
} |
only readily or commercially available reagents are required : isotype-specific , anti-human ig murine monoclonal antibodies ( mab ) to coat microtiter plates , polyclonal alkaline phosphatase-coupled isotype-specific f ( ab ) ' 2 or fab ' fragments as second antibodies , and an enhanced developing system that amplifies the signal-to-noise ratio of the quantitatively bound second antibody . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
63,
70
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
383,
391
]
} |
however , when lps from salmonella minnesota r5 and salmonella minnesota r7 and lipid a from salmonella minnesota r595 were administered , the survival rate was much higher and no histological changes in the liver such as necrosis could be seen in any of the mice . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
15,
18
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
80,
87
]
} |
in patients with decompensated liver cirrhosis , the reduction in the tba and cdca levels after the peaks was slow , and gcdca and tcdca levels continued to increase until 180 min after the administration of cdca . | NA | {
"id": "C0017903",
"name": "gcdca",
"pos": [
121,
126
]
} | {
"id": "C0008024",
"name": "cdca",
"pos": [
208,
212
]
} |
in patients with decompensated liver cirrhosis , the reduction in the tba and cdca levels after the peaks was slow , and gcdca and tcdca levels continued to increase until 180 min after the administration of cdca . | NA | {
"id": "C0039356",
"name": "tcdca",
"pos": [
131,
136
]
} | {
"id": "C0008024",
"name": "cdca",
"pos": [
208,
212
]
} |
the percentage of tac+ cells in t cell fraction from peripheral blood mononuclear cells in unstimulated cultures was 7.9 +/- 2.1 % ( +/- sd ) in controls . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "cell",
"pos": [
82,
86
]
} |
the larger dose of pentagastrin significantly increased tumor growth in the nude mouse ( p less than 0.005 ) and gastrin induced a biphasic effect on deoxyribonucleic acid synthesis in tissue culture with significant increases of up to 39 % ( p less than 0.025 ) . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
19,
31
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
113,
120
]
} |
plasma hanf was 742 +/- 227 pg/ml ( mean +/- sem ) in patients with frfc compared with 360 +/- 70 pg/ml in patients with liver disease and normal serum creatinine ( p greater than 0.05 ) and 28 +/- 5.7 pg/ml in healthy volunteers ( p less than 0.005 vs. frfc and chronic liver disease , ascites , and normal serum creatinine ) . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
121,
134
]
} | {
"id": "C0023890",
"name": "frfc",
"pos": [
254,
258
]
} |
resting plasma epinephrine and norepinephrine levels were 13.1 and 2.1 nmol liter-1 for the marine toad ( bufo marinus ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} |
this was reflected in the ultrastructure of cells where numerous lipid globules ( spherosomes , oleosomes ) appeared around extensive membrane-bound compartments containing membrane vesicles and lipoprotein material . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
65,
70
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
195,
206
]
} |
incubations in the presence of metallic cations did not affect the binding , indicating that ionic forces play no role in the affinity . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
40,
47
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
93,
98
]
} |
comparisons of the binding of afb1 to the bovine-eye pigment in media containing n-propanol , ethanol or methanol indicated that hydrophobic interactions play a role in the affinity . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
94,
101
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
105,
113
]
} |
supraventricular tachycardias can be observed in 10.5 to 32 % of which sinus tachycardia ( heart rate greater than 120 beats per minute ) , paroxysmal atrial tachycardia and intermittent atrial fibrillation at about 5 to 6 % each are not more common than in control subjects . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardias",
"pos": [
0,
29
]
} | {
"id": "C0039239",
"name": "sinus tachycardia",
"pos": [
71,
88
]
} |
the variant ( ii ) differs from the known structure of porcine proinsulin ( i ) by a deletion of alanine c-39 ( the 7th residue of the c-peptide ) . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
63,
73
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
135,
144
]
} |
using the forearm technique , muscular ketone body metabolism was investigated in 12 healthy volunteers during an i.v . infusion of lipid emulsions containing long chain triglycerides ( lct ) or a mixture of medium- and long chain triglycerides ( mct/lct ) . | NA | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
170,
183
]
} | {
"id": "C0724624",
"name": "medium",
"pos": [
208,
214
]
} |
we hypothesize that the myelofibrosis is more than a mere coincidence since other myeloproliferative disorders have been observed in conjunction with afh . | NA | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
24,
37
]
} | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
82,
110
]
} |
however , similar tissue deposits and tissue damage occasionally occur in the absence of a serum or urine paraprotein , in which case other clinical data are necessary to suggest the need for examination of tissue for ig heavy and light chain determinants in order to provide a correct diagnosis of dysproteinemia . | NA | {
"id": "C0030490",
"name": "paraprotein",
"pos": [
106,
117
]
} | {
"id": "C0021027",
"name": "ig",
"pos": [
232,
234
]
} |
studies of the ig synthesized by cultured bone marrow plasma cells , and biochemical analyses of the deposited material , have demonstrated structural abnormalities of paraproteins which may be responsible for their tissue deposition . | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
15,
17
]
} | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
168,
180
]
} |
these observations confirm that the centrocytic lymphoma represents a distinct entity , although its normal counterpart is still unknown , and question the view that the immunocytoma and the mantle zone lymphoma correspond to homogenous categories of non-hodgkin 's lymphomas . | NA | {
"id": "C0334634",
"name": "mantle zone lymphoma",
"pos": [
191,
211
]
} | {
"id": "C0024305",
"name": "categories",
"pos": [
237,
247
]
} |
we support the theory that oncocytic cardiomyopathy is a hamartomatous lesion , and propose as a paradigm the association between cardiac rhabdomyoma and tuberous sclerosis . | NA | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
57,
70
]
} | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
154,
172
]
} |
the antibacterial activity of fleroxacin was evaluated in 427 gram-positive and gram-negative strains , all isolated recently from clinical specimens and compared to that of ofloxacin , ciprofloxacin and co-trimoxazole . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
30,
40
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
186,
199
]
} |
when pbmc were separated into adherent and non-adherent cells , the non-adherent fraction could be induced to lytic activity against ec , whereas the adherent cells could not . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
5,
9
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
159,
164
]
} |
cell populations of human pregnancy decidua , obtained by enzymic digestion from first trimester samples , were analysed by flow cytometry after labelling with monoclonal antibodies . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
26,
35
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
81,
96
]
} |
studies with insulin species variants showed that the molecular binding between antibody and insulin may be critically determined by a subresidue feature , e.g . presence or absence of a single methyl group , as shown by the binding of the monoclonal antibody d10 to human insulin ( threonine at b30 ) but not to rabbit insulin ( serine at b30 ) . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
267,
280
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
320,
327
]
} |
this was not due solely to differences in receptor affinity , as complexes in which the hapten epitopes were unmasked also evoked little virgin b-cell response . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
88,
94
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
95,
103
]
} |
the results of these experiments suggest that the immune clearance of t. cruzi is due to antibodies located in the igg isotype , particularly in the igg2 subclass . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
89,
99
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
119,
126
]
} |
actin concentration for cultured human skin fibroblasts by this technique was estimated to be 55.5 picograms/cell and constituted approximately 3.9 % of the total cellular protein . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
163,
171
]
} |
additionally , enzyme linked immunosorbant assays revealed binding of the monoclonal antibodies to specific antigens , and the antibodies failed to recognize commonly crossreactive antigens such as dna , histone , poly-l-lysine , glycophorin , and serum glycoproteins . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
74,
95
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
127,
137
]
} |
the b lymphocytes and macrophages of lipopolysaccharide ( lps ) nonresponder c3h/hej mice were found to respond to certain r types of lps endotoxin in a fashion resembling that ordinarily seen with the cells from normal responder mice . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
58,
61
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
138,
147
]
} |
these findings permit a new approach to the study of how lps endotoxin affects cells of the immune system . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
57,
60
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
61,
70
]
} |
neutralization studies showed that the cytotoxins produced by all salmonella strains were immunologically distinct from shiga toxin and the closely related shiga-like toxins produced by escherichia coli . | NA | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
120,
131
]
} | {
"id": "C0148323",
"name": "shiga-like toxins",
"pos": [
156,
173
]
} |
the mutant protein has the attributes of a toxoid and may be useful as a component of vaccines for individuals at risk for infection by p. aeruginosa . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
43,
49
]
} | {
"id": "C0042210",
"name": "vaccines",
"pos": [
86,
94
]
} |
studies with desferrioxamine , an iron chelator effective in preventing formation of the hydroxyl radical from hydrogen peroxide and the superoxide free radical , reduced peroxide levels in infected cells to those found in uninfected cells . | NA | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
111,
128
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
171,
179
]
} |
studies with desferrioxamine , an iron chelator effective in preventing formation of the hydroxyl radical from hydrogen peroxide and the superoxide free radical , reduced peroxide levels in infected cells to those found in uninfected cells . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
137,
147
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
171,
179
]
} |
to further elucidate the importance of t- and b-lymphocyte-mediated responses in host defense against systemic infection with candida albicans , we studied this infection in a murine model of severe combined immunodeficiency ( scid ) . | NA | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
102,
120
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
161,
170
]
} |
[ changes in ultrasonic findings in the liver in relation to parenteral nutrition with long chain triglyceride and medium chain triglyceride/long chain triglyceride lipid solutions ] . | NA | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
98,
110
]
} | {
"id": "C0724624",
"name": "medium chain triglyceride",
"pos": [
115,
140
]
} |
it was found that prior administration of l-carnitine ( 110 , 160 or 560 mg.kg-1 b.w . ) does not modify the clearance rate either of a long chain triglyceride emulsion or of a medium chain triglyceride based emulsion . | NA | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
147,
159
]
} | {
"id": "C0724624",
"name": "medium chain triglyceride",
"pos": [
177,
202
]
} |
treatment of antigen yh206 with alkali suggested that the antigenic determinant consists of carbohydrate chains of mucin type . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
13,
20
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
58,
79
]
} |
neuraminidase treatment of antigen yh206 indicated that the epitope is cryptic and contains an asialocarbohydrate chain . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
27,
34
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
60,
67
]
} |
immunoprecipitation of cells labelled with 32p-orthophosphate showed that ebna-2 , but not the associated proteins , is a phosphoprotein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
106,
114
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
122,
136
]
} |
these fpc fibroblasts form greater amounts of unintegrated viral dna as compared to normal fibroblasts during the first 4 to 24 hr after infection with kirsten msv ( kimlv ) , suggesting that increased susceptibility of fpc cells to msv is determined at an early stage of viral transformation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
10,
21
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
224,
229
]
} |
the cells grew well in culture up to 50 passages and showed a fibroblast-like morphology . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
62,
72
]
} |
mad2 cross-reacts to varying degrees with anthracycline compounds such as some dxr analogues and derivatives , but does not recognize anthracene and anthraquinone structures , with the exception of weakly reacting mitoxantrone . | NA | {
"id": "C0003174",
"name": "anthraquinone",
"pos": [
149,
162
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
214,
226
]
} |
effects of four known blockers of t-lymphocyte potassium channels [ verapamil , quinine , 4-aminopyridine ( 4-ap ) and tetraethylammonium ( tea ) ] , were studied on polyclonal t-cell activation induced by two plant mitogens ( phytohemmaglutinin ; pha and concanavalin a ; cona ) , a mitogenic anti-thy 1.2 monoclonal antibody ( mab g7 ) and phorbol ester ( phorbol myristate acetate ; pma ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
342,
355
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
386,
389
]
} |
the toxicity of ara-c was effectively reversed by an excess of deoxycytidine , but not by cytidine or other conventional nucleosides , which is highly suggestive that the molecular mechanism of ara-c toxicity is based on its anti-metabolic role in the salvage pathway of biosynthesis of dna deoxycytidine . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
63,
76
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
296,
304
]
} |
free epinephrine ( epi ) increases showed a highly significant correlation with ne except during fin swimming with a neoprene suit where epi concentrations were constantly higher . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
8,
10
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
137,
140
]
} |
we investigated the effects of exercise on the sympathoadrenal system by determining catecholamine ( ca ) concentrations in the venous blood and urine [ free norepinephrine ( ne ) , epinephrine ( epi ) ] and the respective sulfoconjugates in plasma and various hormonal , metabolic , and cardiocirculatory parameters . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
158,
172
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
182,
193
]
} |
the sports disciplines ' specific differences in ne/epi both at rest and during exercise suggest that the overall sympathetic activity , reflected by ne and epi , is regulated in a quite differentiated pattern . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
19,
21
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
157,
160
]
} |
after this treatment heart rate ( hr ) and mean arterial blood pressure ( mbp ) were not higher than in the other forms of regeneration , although the norepinephrine ( ne ) and epinephrine ( epi ) increase was significantly higher after the second run compared with other treatments . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
151,
165
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
177,
188
]
} |
norepinephrine ( ne ) , epinephrine ( epi ) , and dopamine ( da ) were determined in the blood plasma of 122 subjects by high-performance liquid chromatography with amperometric detection ( hplca ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} |
the range of normal values in the supine position was 0.15-3.50 nmol/l for ne , 0.01-0.80 nmol/l for epi , and 0.04-4.50 nmol/l for da . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
38,
40
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
101,
104
]
} |
after reduction of these ketosulfates by sodium borohydride in dry pyridine , ne-3-o-s and epi-3-o-s were obtained respectively . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
73,
75
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
91,
94
]
} |
the highly purified products ( da-4-o-s , ne-3-o-s , epi-3-o-s ) were characterized by their melting points ( mp ) , infrared spectra ( ir ) , thin-layer chromatography ( tlc ) , high-performance liquid chromatography ( hplc ) , elemental analysis , and 1h-nuclear magnetic resonance spectroscopy ( 1h-nmr ) . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
42,
44
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
53,
56
]
} |
electron microscopy revealed a diverse cellular population composed of conspicuous lipid-laden cells , fibroblast-like and undifferentiated primitive mesenchymal cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
95,
100
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
103,
113
]
} |
human lymphoblastoid raji cells and mouse hybridoma ascites cells incubated with 20 mm creatine showed significant increases in creatine , creatine phosphate and adenine nucleotide levels and in the energy charge . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
87,
95
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
139,
157
]
} |
two classes of adenosine binding sites were identified in pig ventricular sarcolemma using 5'-n- [ 3h ] ethylcarboxamideadenosine ( [ 3h ] neca ) as radioligand ( bmax = 88 fmol/mg protein , kd = 28 nm ; bmax = 7100 fmol/mg protein , kd = 730 nm ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
139,
143
]
} |
in vitro radiobiologic survival parameters have been determined for 7 human osteosarcoma , 5 human soft tissue and bone sarcomas , and 4 ewing 's sarcoma cell lines . | NA | {
"id": "C0029463",
"name": "bone sarcomas",
"pos": [
115,
128
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
137,
153
]
} |
a study population of 100 patients receiving an ag ( gentamicin : 51 , tobramycin : 33 , amikacin : 16 ) was randomly selected from a total population of 250 patients who received ag therapy during august 1985 . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
53,
63
]
} | {
"id": "C0002556",
"name": "ag",
"pos": [
180,
182
]
} |
the observation that imidazole-containing compounds cause significant effects on semicircular canal neurotransmission provides an important finding with regard to the site of action of antihistamines used for the treatment of vertigo and motion sickness . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
140,
147
]
} | {
"id": "C0026603",
"name": "motion sickness",
"pos": [
238,
253
]
} |
amoxycillin and ampicillin induced more beta-lactamase than the inhibitors , but were much less effective than cefoxitin , except for the strain of prov . rettgeri . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
0,
11
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
16,
26
]
} |
forty-nine clinical strains of coagulase-negative staphylococci were investigated for susceptibility to methicillin , oxacillin , cloxacillin , dicloxacillin , flucloxacillin and cephalothin . | NA | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
118,
127
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
163,
174
]
} |
forty-nine clinical strains of coagulase-negative staphylococci were investigated for susceptibility to methicillin , oxacillin , cloxacillin , dicloxacillin , flucloxacillin and cephalothin . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
130,
141
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
144,
157
]
} |
forty-nine clinical strains of coagulase-negative staphylococci were investigated for susceptibility to methicillin , oxacillin , cloxacillin , dicloxacillin , flucloxacillin and cephalothin . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
130,
141
]
} | {
"id": "C0016267",
"name": "flucloxacillin",
"pos": [
160,
174
]
} |
ly163892 had activity similar to cefaclor and cephalexin with mic90 values of 16 mg/l for escherichia coli , 8 mg/l for klebsiella pneumoniae , proteus mirabilis , yersinia enterocolitica , but was more active against haemophilus influenzae , and branhamella catarrhalis . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
33,
41
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
46,
56
]
} |
overall it had beta-lactamase stability similar to cefaclor , less than cephalexin , and markedly less than cefuroxime . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
51,
59
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
72,
82
]
} |
the aminoglycosides ( gentamicin , netilmicin ) , oxacillin and ly146032 , a new lipopeptidic antibiotic , had a penetration which was generally less than 60 % , whereas new fluoro-quinolones ( enoxacin , ciprofloxacin , ci934 , ro236240 ) and rifamycins ( rifampicin , lm427 ) were concentrated 2.4 to 14.2-fold . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
4,
19
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
22,
32
]
} |
the aminoglycosides ( gentamicin , netilmicin ) , oxacillin and ly146032 , a new lipopeptidic antibiotic , had a penetration which was generally less than 60 % , whereas new fluoro-quinolones ( enoxacin , ciprofloxacin , ci934 , ro236240 ) and rifamycins ( rifampicin , lm427 ) were concentrated 2.4 to 14.2-fold . | NA | {
"id": "C0035609",
"name": "rifamycins",
"pos": [
244,
254
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
257,
267
]
} |
the selection of aminoglycoside-resistant bowel flora , following the administration of either gentamicin or netilmicin in combination with metronidazole for prophylaxis , during colo-rectal surgery in 88 patients has been examined . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
17,
31
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
95,
105
]
} |
mics of temocillin , carbenicillin , ticarcillin , mezlocillin , piperacillin and ampicillin were determined for mutant series of enterobacter cloacae , citrobacter freundii , proteus vulgaris , morganella morganii and serratia marcescens with inducible , stably derepressed or basal expression of chromosomal class i beta-lactamases . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
51,
62
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
82,
92
]
} |
mics of temocillin , carbenicillin , ticarcillin , mezlocillin , piperacillin and ampicillin were determined for mutant series of enterobacter cloacae , citrobacter freundii , proteus vulgaris , morganella morganii and serratia marcescens with inducible , stably derepressed or basal expression of chromosomal class i beta-lactamases . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
65,
77
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
82,
92
]
} |
carbenicillin , ticarcillin , mezlocillin , piperacillin ( and ampicillin for c. freundii ) were active against both inducible and basal organisms ( mic less than 16 mg/l ) , but inactive against the derepressed mutants ( mics usually greater than 64 mg/l ) . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
30,
41
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
63,
73
]
} |
carbenicillin , ticarcillin , mezlocillin , piperacillin ( and ampicillin for c. freundii ) were active against both inducible and basal organisms ( mic less than 16 mg/l ) , but inactive against the derepressed mutants ( mics usually greater than 64 mg/l ) . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
44,
56
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
63,
73
]
} |
ly163892 was found to be similar to cefaclor and slightly superior to cephalexin in antimicrobial activity and spectrum . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
36,
44
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
70,
80
]
} |
macrolide antibiotics constitute a group of 12 to 16-membered lactone rings substituted with one or more sugar residues , some of which may be amino sugars . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
105,
110
]
} | {
"id": "C0002531",
"name": "amino sugars",
"pos": [
143,
155
]
} |
enoxacin does not impair the metabolism of chlorpropamide or glibenclamide , it is therefore unlikely that any of the quinolones will interact with sulphonylurea hypoglycaemic drugs . | NA | {
"id": "C0008287",
"name": "chlorpropamide",
"pos": [
43,
57
]
} | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
148,
161
]
} |
enoxacin does not impair the metabolism of chlorpropamide or glibenclamide , it is therefore unlikely that any of the quinolones will interact with sulphonylurea hypoglycaemic drugs . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
61,
74
]
} | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
148,
161
]
} |
the adult respiratory distress syndrome ( ards ) is frequently caused by exposure of the lung endothelium to circulating endotoxin ( lipopolysaccharide , lps ) and pulmonary infections frequently develop during the course of ards . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
121,
130
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
154,
157
]
} |
antioxidant enzymes were not increased , but reduced glutathione ( gsh ) levels fell and oxidized glutathione ( gssg ) increased , reflecting the oxidant stress of o2 exposure . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
67,
70
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
112,
116
]
} |
treatment with endotoxin did not increase antioxidant enzyme levels in lung homogenate , but levels of gsh relative to gssg were significantly elevated . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
103,
106
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
119,
123
]
} |
the experimental conditions included beta 1-adrenergic blockade ( metoprolol tartrate ) , parasympathetic blockade ( atropine sulfate ) , or complete blockade ( metoprolol and atropine ) . | NA | {
"id": "C0700548",
"name": "metoprolol tartrate",
"pos": [
66,
85
]
} | {
"id": "C0025859",
"name": "metoprolol",
"pos": [
161,
171
]
} |
examination with an electron microscope revealed that the corneal fibroblasts in collagen gel formed gap junctions with neighboring cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
66,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} |
as primary tissue of this origin is difficult to obtain in large quantities and shows cellular heterogeneity , the hig-82 cell line should facilitate research into the biology and biochemistry of the fibroblastic cells that line the diarthrodial joints of mammals . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
86,
94
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
200,
218
]
} |
the mean blocking antibody factor in the immune serum of the cra-it group showed a 2.5 x 10 ( 2 ) -fold increase [ 1.3 +/- 0.3 x 10 ( -1 ) in postimmune serum/5.2 +/- 2.0 +/- 10 ( -4 ) in preimmune serum ( p less than 0.001 ) ] . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
18,
26
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
191,
203
]
} |
moreover , there was less binding of o-antigen-specific bacteriophage to s. marcescens with increasing growth temperature , a finding consistent with temperature-mediated changes in lps structure . | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
37,
46
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
182,
185
]
} |
moreover , there was less binding of o-antigen-specific bacteriophage to s. marcescens with increasing growth temperature , a finding consistent with temperature-mediated changes in lps structure . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
126,
133
]
} | {
"id": "C0005904",
"name": "temperature",
"pos": [
150,
161
]
} |
the similarity of amino acid compositions between a. salina and rat liver 40s ribosomal proteins was evaluated by the method of cornish-bowden ( cornish-bowden , a . ( 1980 ) anal . biochem . 105 , 233-238 ) , and possible relationships between a. salina and rat were detected for 16 protein species ( s2 , s3 , s4 , s6 , s7 , s8 , s15a , s16 , s17 , and s18 , strongly related and s14 , s15 , s20 , s23 , s24 , and s26 , weakly related ) , indicating a conservative nature of eukaryotic ribosomal proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
488,
506
]
} |
the results of this study indicated that allo a strongly binds to the trisaccharide structure , neuac alpha 2-3 ( 6 ) gal-beta 1-4glcnac , and that its binding potency is affected by the inner core structures of oligosaccharides and glycopeptides , because the presence of a bisecting n-acetyl-glucosamine residue and an alpha-fucose residue linked to the innermost n-acetylglucosamine residue reduced the association constants for oligosaccharides and glycopeptides . | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
70,
83
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
432,
448
]
} |
the results of this study indicated that allo a strongly binds to the trisaccharide structure , neuac alpha 2-3 ( 6 ) gal-beta 1-4glcnac , and that its binding potency is affected by the inner core structures of oligosaccharides and glycopeptides , because the presence of a bisecting n-acetyl-glucosamine residue and an alpha-fucose residue linked to the innermost n-acetylglucosamine residue reduced the association constants for oligosaccharides and glycopeptides . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
294,
305
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
368,
385
]
} |
we have found a proteolytic activity in golgi membranes which efficiently converts [ 35s ] methionine-labeled proalbumin , isolated from pulse-labeled rat hepatocytes in culture , to serum albumin in an in vitro assay system . | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
110,
120
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
183,
196
]
} |
3 ) synthesis of adult type ( hba and hba2 ) and fetal type ( hbf ) hemoglobins , as detected on isoelectric focusing ; | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
30,
33
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
68,
79
]
} |
3 ) synthesis of adult type ( hba and hba2 ) and fetal type ( hbf ) hemoglobins , as detected on isoelectric focusing ; | NA | {
"id": "C0015936",
"name": "hbf",
"pos": [
62,
65
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
68,
79
]
} |
moreover , analysis of the inhibition of the caseinolytic activity of papain by these kininogens indicated that hmwk , lmwk , and kinin-free derivatives obtained from both kininogens inhibit active papain with a stoichiometry of 1:1 . | NA | {
"id": "C0019536",
"name": "hmwk",
"pos": [
112,
116
]
} | {
"id": "C0022713",
"name": "kininogens",
"pos": [
172,
182
]
} |
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