text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
trypsin-treated htg-vldl ( tryp-vldl ) , devoid of apolipoprotein ( apo ) -e , fail to bind to the ldl receptor , yet tryp-vldl and htg-vldl cross-compete for binding to p388d1 macrophage receptors , indicating that these lipoproteins bind to the same sites . | NA | {
"id": "C0023825",
"name": "htg-vldl",
"pos": [
16,
24
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
222,
234
]
} |
we conclude that macrophages possess receptors for abnormal human triglyceride-rich lipoproteins that are distinct from ldl receptors in ligand specificity , regulation , immunological characteristics , and cellular distribution . | NA | {
"id": "C0065059",
"name": "receptors",
"pos": [
37,
46
]
} | {
"id": "C0034821",
"name": "ldl receptors",
"pos": [
120,
133
]
} |
in contrast to the 7.6-kd serum igf-i , gel chromatography revealed that the alveolar macrophage igf-i had an apparent molecular mass of 26 kd , similar to other tissue igf-is . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
32,
37
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
169,
172
]
} |
his trauma was unique in that it consisted of a static loading force to the brow , rather than the dynamic impact more commonly associated with blunt orbital injuries . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
4,
10
]
} | {
"id": "C0043253",
"name": "blunt",
"pos": [
144,
149
]
} |
our findings provide additional evidence that destructive periodontal disease should not be perceived as an inevitable consequence of gingivitis which ultimately leads to considerable tooth loss . | NA | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
58,
77
]
} | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
134,
144
]
} |
techniques for speech therapy are adapted from those used with hyperfunctional voice disorders to fit this debilitating laryngeal disorder . | NA | {
"id": "C0042940",
"name": "voice disorders",
"pos": [
79,
94
]
} | {
"id": "C0023051",
"name": "laryngeal disorder",
"pos": [
120,
138
]
} |
although urticaria and facial and peripheral edema are well recognized idiosyncratic reactions to ionic contrast medium , to our knowledge , isolated angioedema of the small bowel has not been reported previously . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
9,
18
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
150,
160
]
} |
soybean meal treatments consisted of 30 % vol/vol isopropanol , 40 % propanol , or 50 % ethanol at 22 degrees c or 70 % ethanol at 80 degrees c . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
50,
61
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
120,
127
]
} |
soybean meal treated with 40 % propanol had the greatest reduction in absorbance of all effluents at 275 nm , followed by soybean meal treated with 50 % ethanol or 30 % isopropanol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
153,
160
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
169,
180
]
} |
a new oxidation method using ion-sputtering was developed , and the effectiveness of this surface treatment on two dental alloys -- a type iv gold alloy and ni-cr-be alloy -- was investigated . | NA | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
142,
152
]
} | {
"id": "C0002154",
"name": "alloy",
"pos": [
166,
171
]
} |
further , radioisotopic fluxes showed that the increase in isc in eost-exposed tissues was accompanied by increased absorption of electrolytes ( na , cl , and other ions ) , and the decrease in r was accompanied by increased permeability to mannitol . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
130,
142
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
165,
169
]
} |
to determine the effect of electrolyte release on buccal function , we exposed mucosae luminally to a solution with ion composition and/or osmolality similar to eost or to one with an eost previously dialyzed against ringer . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
27,
38
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
128,
131
]
} |
an unusual patient with aneg is described in which the presenting feature was an extensive granulomatous lesion of the face . | NA | {
"id": "C0008728",
"name": "aneg",
"pos": [
24,
28
]
} | {
"id": "C0018188",
"name": "granulomatous lesion",
"pos": [
91,
111
]
} |
the expected plasma total cholesterol ( specifically low-density-lipoprotein cholesterol ) reduction is approximately 10 % to 20 % when dietary saturated fatty acids and cholesterol are decreased to less than or equal to 7 % of calories and less than or equal to 200 mg of cholesterol per day . | NA | {
"id": "C0023824",
"name": "low-density-lipoprotein cholesterol",
"pos": [
53,
88
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
273,
284
]
} |
high sensitivity of the microsomal antigen epitopes recognized by autoantibodies in sera of patients with thyroid autoimmune diseases to disulphide bridge reducing agents have been detected . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
35,
42
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
43,
51
]
} |
the incidence of metastatic endophthalmitis was 1.7 % in patients with pyogenic liver abscess , 5.2 % in patients with klebsiella liver abscess , and 7.8 % in patients with klebsiella liver abscess having klebsiella bacteremia . | NA | {
"id": "C0267830",
"name": "pyogenic liver abscess",
"pos": [
71,
93
]
} | {
"id": "C0023885",
"name": "liver abscess",
"pos": [
184,
197
]
} |
effect of various bile salts on calcium concentration and calcium carbonate saturation of rat bile . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
32,
39
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
58,
75
]
} |
six patients with essential hypertension underwent a randomized cross over design study to investigate the effect of supplementing a 10 mmol/day sodium diet for a period of 5 days with either 120 mmol sodium chloride ( slow sodium , ciba , horsham , uk ) or 122 mmol sodium in the presence of other anions , mainly phosphate ( phosphate , sandoz , feltham , uk ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
299,
305
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
327,
336
]
} |
in separate experiments the effects of chronic treatment with lisinopril at two dosage levels on various physiological parameters of streptozotocin-diabetic rats were compared with the effects of another hypotensive agent , hydralazine , an arteriolar vasodilator . | NA | {
"id": "C0020223",
"name": "hydralazine",
"pos": [
224,
235
]
} | {
"id": "C2267010",
"name": "arteriolar vasodilator",
"pos": [
241,
263
]
} |
these studies indicated that bryo has potent immunopotentiating properties that share some similar effects of the phorbol ester , pma , but offers the additional property of modulating other phorbol ester effects on proliferation . | NA | {
"id": "C0039654",
"name": "pma",
"pos": [
130,
133
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
191,
204
]
} |
class i h-2kd-restricted influenza hemagglutinin ( ha ) -specific ctl recognize two immuno-dominant sites as represented by synthetic peptides spanning epitopes located in the ha1 and hydrophobic transmembrane domains of the influenza ha . | NA | {
"id": "C0079600",
"name": "immuno-dominant sites",
"pos": [
84,
105
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
152,
160
]
} |
a graft-vs-host ( gvh ) reaction of parental t cells in allogeneic f1 mice can lead to an autoimmune disease resembling human sle . | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
90,
108
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
126,
129
]
} |
using northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts , and specific biologic and immunologic assays to detect the presence of colony-stimulating factors in the serum , we have found that tnf-alpha and tnf-beta induce the transcription and production of granulocyte-macrophage-csf , macrophage-csf , and il-1 . | NA | {
"id": "C0021757",
"name": "hematopoietic growth factor",
"pos": [
56,
83
]
} | {
"id": "C0009392",
"name": "colony-stimulating factors",
"pos": [
178,
204
]
} |
both the cd5+ wild type jurkat and the cd5+ infectant responded equivalently to purified il-1 , il-1 alpha and ril-1 beta . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
89,
93
]
} | {
"id": "C0600251",
"name": "il-1",
"pos": [
112,
116
]
} |
although , the enzyme in these peaks had similar m.w . and identical iso-electric mobility , the proteins differed with respect to their autophosphorylation sites and immunoreactivity toward an isoform specific antibody . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
97,
105
]
} | {
"id": "C0597298",
"name": "isoform",
"pos": [
194,
201
]
} |
in contrast to other animals , the biosynthesis of serum amyloid p component in mice is regulated as an acute-phase protein . | NA | {
"id": "C0002721",
"name": "serum amyloid p component",
"pos": [
51,
76
]
} | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
104,
123
]
} |
experiments to define the optimal treatment regimen in this model showed that , although the administration of saporin and bispecific ab at separate sites could be therapeutically effective , mixing the ab and saporin to form immune complexes before injection did generally enhance their performance . | NA | {
"id": "C0206492",
"name": "bispecific ab",
"pos": [
123,
136
]
} | {
"id": "C0003241",
"name": "ab",
"pos": [
203,
205
]
} |
experiments to define the optimal treatment regimen in this model showed that , although the administration of saporin and bispecific ab at separate sites could be therapeutically effective , mixing the ab and saporin to form immune complexes before injection did generally enhance their performance . | NA | {
"id": "C0003241",
"name": "ab",
"pos": [
134,
136
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
226,
242
]
} |
in the present study , we report the surprising observation that multi-valent cross-linking of cd8 molecules on precursor cells by specific antibody actively induces the generation of cd8+ class i allospecific ctl whose lytic function is resistant to anti-cd8 antibody inhibition , and actively induces down-modulation of cell surface cd8 expression on these cells . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
112,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
359,
364
]
} |
a polylysine extended gibbon il-2 ( il-2-l ) was constructed by the addition of a lysine-rich oligopeptide , gly3- ( lys-lys-asp ) 3-leu-glu to the c terminus of gibbon il-2 by using rdna technology . | NA | {
"id": "C0032518",
"name": "polylysine",
"pos": [
2,
12
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
82,
88
]
} |
in this report , we demonstrate that 1 ) il-1 production is a common property of murine t cell clones , 2 ) t cell il-1 activity is blocked by anti-il-1-alpha antiserum , 3 ) il-1-alpha mrna can be directly visualized in individual cloned t cells using in situ hybridization techniques , and 4 ) il-1 appears to serve an autocrine role in the activation of t cell clones inasmuch as anti-il-1-alpha antiserum blocks cell proliferation when the t cell is the only il-1 source . | NA | {
"id": "C0600251",
"name": "il-1-alpha",
"pos": [
148,
158
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
463,
467
]
} |
of the 43 mab tested , 25 antibodies recognized sequences common to all five isoforms , 16 antibodies recognized isoforms that include exon a encoded sequences , one antibody recognized isoforms that include exon b encoded sequences , and one antibody recognized only the isoform that does not include either exon a , b , or c encoded sequences . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
10,
13
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
243,
251
]
} |
it was found that all the isolated ic may contain igg , iga and igm antibodies reacting with actin tubulin and tnp/bsa and also , depending upon the disease , antibodies reacting with some of the other antigens of the panel . | NA | {
"id": "C0003313",
"name": "ic",
"pos": [
35,
37
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
159,
169
]
} |
by comparison to the antibodies present in the original sera , higher titers of antibodies were found in the isolated ic while some antibody specificities not detected in a given serum were occasionally noted in the isolated ic . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
21,
31
]
} | {
"id": "C0003313",
"name": "ic",
"pos": [
225,
227
]
} |
the antibodies present in the ic seem to possess characteristics similar to those of polyreactive human natural autoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0003313",
"name": "ic",
"pos": [
61,
63
]
} |
the antibodies present in the ic seem to possess characteristics similar to those of polyreactive human natural autoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
112,
126
]
} |
in these studies the endotoxin was incorporated into liposomes by suspending the wt-lps in the buffer used to rehydrate the lipid . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
21,
30
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
84,
87
]
} |
ribosomal rna banding patterns in agarose gel electrophoresis and in vitro translation experiments indicate that the isolated rna can be employed for analysis of molecular mechanisms of mast cell function and heterogeneity . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
0,
13
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
126,
129
]
} |
a high molecular weight form of il-1 beta was demonstrated under certain conditions and the two enzyme immunoassays were successfully applied to the detection of il-1 alpha and il-1 beta present in cell supernatants following stimulation with mitogenic or chemical agents . | NA | {
"id": "C0021755",
"name": "il-1 beta",
"pos": [
32,
41
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
162,
172
]
} |
incorporating amphotericin b into liposomes was reported to decrease amphotericin b toxicity without a concomitant loss of antifungal efficacy . | NA | {
"id": "C1145701",
"name": "amphotericin b",
"pos": [
14,
28
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
69,
83
]
} |
relation of circulating levels of human immunodeficiency virus ( hiv ) antigen , antibody to p24 , and hiv-containing immune complexes in hiv-infected patients . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
81,
89
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
118,
134
]
} |
isotype distribution and bactericidal activity of antibodies after immunization with haemophilus influenzae type b vaccines at 18-24 months of age . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
0,
7
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
50,
60
]
} |
kinetic constants of factor beta-xiia ( factor xii fragment ) for these substrates and for n-benzol-l-isoleusyl-l-glutamyl-glycyl-l-arginine-p-nitro ani lide ( s-2222 ) were determined , and they allowed the assessment of the contribution of this factor to this assay and its estimation in the activated phase . | NA | {
"id": "C0015527",
"name": "factor",
"pos": [
21,
27
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
40,
50
]
} |
both igf-i and igf-ii levels decreased as liver disease progressed from the normal control stage to chronic hepatitis and cirrhosis , and both levels reflected the severity of liver disease . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
122,
131
]
} | {
"id": "C0023895",
"name": "the",
"pos": [
160,
163
]
} |
beef , pork , and human insulin , in quantities determined from titration curves , were added to fixed amounts of antibody to obtain equivalent amounts of ics . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
114,
122
]
} | {
"id": "C0003313",
"name": "ics",
"pos": [
155,
158
]
} |
for four different antibodies , the ratios of pca ( expressed by hbms exposed to ics or to antibodies alone and normalized for cell numbers ) to activity expressed by tissue culture medium were as follows : beef insulin ics , 2.55 +/- 0.41 ; | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
19,
29
]
} | {
"id": "C0003313",
"name": "ics",
"pos": [
220,
223
]
} |
for a fifth antibody , a dose response between beef insulin ics and pca expression was demonstrated . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
12,
20
]
} | {
"id": "C0003313",
"name": "ics",
"pos": [
60,
63
]
} |
preincubation of human neutrophils with recombinant tumor necrosis factor alpha has previously been shown by us to enhance superoxide production of neutrophils in response to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine , and the phorbol ester , phorbol myristate acetate . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
247,
260
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
263,
288
]
} |
the effects of three retinoids , all-trans-retinoic acid ( ra ) , 13-cis-retinoic acid ( cra ) , and n- ( 4-hydroxyphenyl ) retinamide ( 4-hpr ) , on macrophage function were evaluated . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
21,
30
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic",
"pos": [
66,
81
]
} |
after immunofluorescence staining with m phi specific monoclonal antibodies ( mabs ) and phycoerythrin ( pe ) second antibody , the resident m phi were labeled with both the green dye and red mab label , while recruited m phi were labeled only with the red mab tag . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
117,
125
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
257,
260
]
} |
this investigation was conducted to identify all fatty acids present in the lamellar body phosphatidylcholine , and to determine whether the low level of disaturated phosphatidylcholine is due to excessive unsaturated fatty acid at position sn-1 , sn-2 , or both . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
49,
54
]
} | {
"id": "C0015690",
"name": "unsaturated",
"pos": [
206,
217
]
} |
d ) the liver uptake of hl-treated chylomicrons was competitively inhibited by endogenously generated chylomicron remnants , indicating that these two types of lipoproteins share the same process of recognition and uptake by liver cells . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
35,
47
]
} | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
102,
122
]
} |
d ) the liver uptake of hl-treated chylomicrons was competitively inhibited by endogenously generated chylomicron remnants , indicating that these two types of lipoproteins share the same process of recognition and uptake by liver cells . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
35,
47
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
160,
172
]
} |
apob and apoa-i mass are determined by radioimmunoassay and newly synthesized apolipoprotein characterized following [ 3h ] leucine intraduodenal infusion . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
0,
4
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
78,
92
]
} |
lipid feeding doubled the percentage of intracellular apoa-i bound to lipoproteins and increased the percentage of intracellular apob bound to lipoproteins by 65 % . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
143,
155
]
} |
the constant presence of a large non-lipoprotein-bound pool suggests that apolipoprotein synthesis is not the rate limiting step in lipoprotein assembly or secretion . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
9,
10
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
132,
143
]
} |
during the course of these studies , we discovered that a lipoprotein comparable to human lp [ a ] was a prominent component of the plasma lipoprotein spectrum in the hedgehog . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
58,
69
]
} | {
"id": "C0065058",
"name": "lp [ a",
"pos": [
90,
96
]
} |
its apolipoprotein moiety consisted of two proteins with molecular weights and amino acid compositions similar to those of human apob-100 and apo [ a ] , respectively . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
4,
18
]
} | {
"id": "C0003592",
"name": "apo [ a",
"pos": [
142,
149
]
} |
the plasma concentration of ldl particles , defined as lipoproteins containing apob-100 as their sole apolipoprotein constituent , was considerably lower than that of lp [ a ] . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
55,
67
]
} | {
"id": "C0065058",
"name": "lp [ a",
"pos": [
167,
173
]
} |
in addition , we found that the increase in cholesterol efflux caused by loading the fibroblasts with cholesterol was no greater when the acceptor particles were hdl3 than when albumin or phospholipid vesicles served as acceptors , despite a marked increase in hdl3 binding to these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
85,
96
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
283,
288
]
} |
because hdl3 binding to these cells and hdl3-mediated cholesterol efflux from these cells do not saturate at similar free hdl3 concentrations , and because the cholesterol-induced increase in hdl3 binding is not accompanied by a similar increase in cholesterol efflux that is specific for hdl3 , we conclude that the described hdl3 binding sites on human fibroblasts do not mediate cholesterol efflux . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
355,
366
]
} |
since another apolipoprotein , apolipoprotein a-i , has been recently shown to have covalently bound fatty acids , potential fatty acid acylation of apolipoprotein b was investigated . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
14,
28
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
149,
165
]
} |
in contrast to circulating apob in low density lipoproteins , both palmitate and stearate were present in newly synthesized apob-100 . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
27,
31
]
} | {
"id": "C0205666",
"name": "apob-100",
"pos": [
124,
132
]
} |
the rhythm for 5-methoxytryptamine appears to be the same as for serotonin ( opposite in phase to that of melatonin ) . | NA | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
17,
34
]
} | {
"id": "C0036751",
"name": "serotonin",
"pos": [
65,
74
]
} |
we have studied the effects of trh and native gonadotrophin-releasing hormone ( gnrh ) , and of a gnrh agonist ( buserelin ; [ d-ser ( but ) 6 ] gnrh ( 1-9 ) nonapeptide-ethylamide ) , on lh , fsh , alpha subunit and lh-beta subunit secretion from three human gonadotrophin-secreting pituitary adenomas in dispersed cell culture . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
113,
122
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
145,
149
]
} |
multi-colony-stimulating factor ( csf ) activity was measured using two assays that can detect murine il-3 ( mast cell proliferation , and bone marrow csf ) . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
6,
31
]
} | {
"id": "C0021757",
"name": "il-3",
"pos": [
102,
106
]
} |
finally , an ria detected 1.6-25 ng/ml of csf-1 in ra sf and st and csf-1 mrna was detected in four of five ra synovial tissue samples tested . | NA | {
"id": "C0079784",
"name": "1",
"pos": [
26,
27
]
} | {
"id": "C0009392",
"name": "csf-1",
"pos": [
68,
73
]
} |
amino acid comparison of mcsp-1 with four other reported serine proteases whose active site pocket residue is alanine revealed that mcsp-1 was substantially different from the other molecules , indicating that mcsp-1 may be a new member of mouse t cell serine protease family . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
110,
117
]
} |
we speculate that when pi is presented in liposomes , the antibodies raised are mainly to surface-exposed epitopes of the protein as opposed to when pi is presented absorbed to alum , where the antibodies are produced mainly to buried epitopes . | NA | {
"id": "C0025252",
"name": "surface",
"pos": [
90,
97
]
} | {
"id": "C0033684",
"name": "pi",
"pos": [
236,
238
]
} |
two isoenzymes of the fourth enzyme ( mannitol-l-phosphate dehydrogenase ) were detected and shown to be localized respectively in the mitochondrion and the cytosol . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
4,
14
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
29,
35
]
} |
the results suggest that lps composition , especially the o-antigen polysaccharide chains , contributes to the susceptibility of e. coli and s. typhimurium strains to complement-mediated serum bactericidal activity . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
25,
28
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
58,
67
]
} |
the specificity of the b-elisa was absolute for antibodies to btv , showing no cross-reaction with experimental antisera to serotypes of the closely related orbivirus causing epizootic haemorrhagic disease of deer . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
48,
58
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
112,
120
]
} |
dual expression transfer vectors containing the hbcag gene sequences and the coding sequences of the hb viral s antigen ( hbsag ) , each gene under the control of its own copy of the polyhedrin promoter , have also been constructed and used to derive recombinant viruses . | NA | {
"id": "C0019166",
"name": "hbcag",
"pos": [
48,
53
]
} | {
"id": "C0019165",
"name": "hb viral",
"pos": [
101,
109
]
} |
dual expression transfer vectors containing the hbcag gene sequences and the coding sequences of the hb viral s antigen ( hbsag ) , each gene under the control of its own copy of the polyhedrin promoter , have also been constructed and used to derive recombinant viruses . | NA | {
"id": "C0019165",
"name": "hb viral",
"pos": [
101,
109
]
} | {
"id": "C0019168",
"name": "hbsag",
"pos": [
122,
127
]
} |
the gene order was determined to be 3 ' nc-p-m-f-sh-hn-l 5 ' ( where nc , p , m , sh , and l represent the genes for the nucleocapsid , phosphoprotein or polymerase-associated , matrix or membrane , small hydrophobic and large proteins respectively ) . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
136,
150
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
227,
235
]
} |
the cell lines showed a repressed phenotype for cat expression , but could be induced for it by inhibition of protein synthesis , as well as by heat-shock and chemical inducers of the cellular stress response , such as sodium arsenite , 8-hydroxyquinoline and the heavy metals cadmium and copper . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
264,
276
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
277,
284
]
} |
the cell lines showed a repressed phenotype for cat expression , but could be induced for it by inhibition of protein synthesis , as well as by heat-shock and chemical inducers of the cellular stress response , such as sodium arsenite , 8-hydroxyquinoline and the heavy metals cadmium and copper . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
264,
276
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
289,
295
]
} |
these results suggested that there is a progressive increase in the concentrations of infectious hiv in plasma from the asymptomatic to the aids stage . | NA | {
"id": "C0019693",
"name": "infectious hiv",
"pos": [
86,
100
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
140,
144
]
} |
these data suggest that the 3.2 kb dna found in the pbmcs is a natural recombinant between hbv and hiv dnas raising the possibility not only that this dna plays a role in the pathogenesis of aids but also that other viral recombinant dnas may be pathogenic in human disease . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
35,
38
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
216,
221
]
} |
incubation with 1 microm phorbol 12-myristate 13-acetate , a phorbol ester , inhibited carbachol-induced , but not naf-induced , [ 3h ] inositol monophosphate production . | NA | {
"id": "C0039654",
"name": "phorbol",
"pos": [
25,
32
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
61,
74
]
} |
immunoblot analysis revealed that the clone-produced buche peptides interact specifically with antibodies against human and torpedo acetylcholinesterase ( ache ) . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
53,
58
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
132,
152
]
} |
rabbit polyclonal antibodies prepared against the purified clone-produced buche polypeptides interacted in immunoblots with denatured serum buche as well as with purified and denatured erythrocyte ache . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
74,
79
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
197,
201
]
} |
furthermore , both ache and buche dimers from muscle extracts , but not buche tetramers from muscle , interacted with these antibodies . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
19,
23
]
} | {
"id": "C0008429",
"name": "buche",
"pos": [
72,
77
]
} |
the anti-cloned buche antibodies , as well as anti-torpedo ache antibodies , created patches of silver grains in the muscle endplate region stained for che , under conditions where control sera did not . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
16,
21
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
59,
63
]
} |
we have investigated the effects of the specific platelet-activating factor ( paf ; 1-alkyl-2-acetyl-glycerophosphocholine ) antagonist bn52021 on free fatty acid ( ffa ) and diacylglycerol ( dg ) accumulation and on the loss of fatty acids from phosphatidylinositol-4,5-bisphosphate ( pip2 ) in mouse brain . | NA | {
"id": "C0015688",
"name": "free fatty",
"pos": [
147,
157
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
229,
240
]
} |
galanin is a recently isolated neuropeptide that is of particular interest in dementing disorders because of its known colocalization with choline acetyltransferase in magnocellular neurons of the basal nucleus of meynert . | NA | {
"id": "C0060993",
"name": "galanin",
"pos": [
0,
7
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
31,
43
]
} |
in this case of fracture of a metal-backed polyethylene acetabular component after a total hip arthroplasty , there was no history of difficulties prior to the component fracture and no history of trauma . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
16,
24
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
197,
203
]
} |
initial weight and weight change were not associated with increased blood pressure , however , when controlling for current weight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
8,
14
]
} | {
"id": "C0005911",
"name": "weight change",
"pos": [
19,
32
]
} |
ifosfamide , an analogue of cyclophosphamide , has therapeutic activity against a wide variety of human malignancies . | NA | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
0,
10
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
28,
44
]
} |
the adhesive properties of either silicon or silicon dioxide ( quartz ) surfaces were controlled by covalently binding small organic molecules to the surface with silane coupling agents . | NA | {
"id": "C0037098",
"name": "silicon dioxide",
"pos": [
45,
60
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
63,
69
]
} |
finally , type ii neurons display at least a 5 times greater sensitivity to iontophoretically applied da than type i cells , suggesting that the 2 cell populations also are affected differentially by dopaminergic input from the substantia nigra . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
102,
104
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
200,
212
]
} |
we estimated the utilization of calcium in spinach and calcium-oxalate to calcium-deficient rats , and the effect of oxalic acid on absorption of dietary calcium by using calcium-deficient rats . | NA | {
"id": "C0006706",
"name": "calcium-oxalate",
"pos": [
55,
70
]
} | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
117,
128
]
} |
the body weight gain of the calcium-deficient rats for 8 days receiving a calcium-deficient diet supplemented with raw-powdered spinach ( r-sp ) , boiled-powdered spinach ( b-sp ) , or calcium-oxalate ( ca-ox ) , and a control diet supplemented with oxalic acid ( ox-c ) were 4.8 , 2.8 , 4.9 , and 5.1 g , respectively . | NA | {
"id": "C0006706",
"name": "calcium-oxalate",
"pos": [
185,
200
]
} | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
250,
261
]
} |
the result of our study confirmed that when the amino acid requirement for maximum growth was expressed as the dietary percentage , amino acid to total amino acid ratio , and amino acid to total nitrogen ratio , the requirement had changed according to not only essential amino acids but also to nonessential amino acids . | NA | {
"id": "C0815040",
"name": "amino",
"pos": [
48,
53
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
309,
319
]
} |
many flavins examined , except for 3-isobutylriboflavin , 3-carboxymethylriboflavin , lumichrome , and riboflavin-5'-monosulfate , interfered with the specific absorption of riboflavin . | NA | {
"id": "C0016213",
"name": "flavins",
"pos": [
5,
12
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
174,
184
]
} |
clear abnormality ( death , cerebral palsy , or developmental delay ) was found in four infants in the preeclampsia group and five in the asphyxia group ; | NA | {
"id": "C0011065",
"name": "death",
"pos": [
20,
25
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
138,
146
]
} |
mean serum pg i concentrations were not significantly higher in the whole patient group than in controls , but pud patients who relapsed after discontinuing ranitidine treatment had shown on admission significantly higher pg i levels when compared both with those who did not relapse and with controls . | NA | {
"id": "C0077923",
"name": "pg i",
"pos": [
11,
15
]
} | {
"id": "C0030913",
"name": "pg i",
"pos": [
222,
226
]
} |
overall , compared with b fed infants , f fed infants gained less weight between birth and 10 days and more weight between 10 and 90 days , although mean actual weights at 90 days were similar ; | NA | {
"id": "C0005612",
"name": "weight",
"pos": [
66,
72
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
161,
167
]
} |
in 51 of the 90 patients , no complications were seen ( 57 % ) , whereas in the remaining 39 , postoperative complications were noted with anastomotic leakage ( 24 patients , 26 % ) , anastomotic stricture ( 16 patients , 18 % ) and gastroesophageal reflux ( 5 patients , 5 % ) . | NA | {
"id": "C0032787",
"name": "postoperative complications",
"pos": [
95,
122
]
} | {
"id": "C0919691",
"name": "anastomotic leakage",
"pos": [
139,
158
]
} |
mga induced the cf in mm46 mammary carcinoma , ehrlich carcinoma , and mh134 hepatoma , the growth of which were all inhibited by mga , but not in lewis lung carcinoma and el-4 lymphoma , which are therapeutically resistant to mga . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
35,
44
]
} | {
"id": "C0243038",
"name": "lewis lung carcinoma",
"pos": [
147,
167
]
} |
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