text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the results show that out of 29 antibiotics tested , the 7 most efficient are : rifampicin ( 91.5 p.c . ) , sisomicin ( 91 p.c . ) , gentamicin ( 85.64 p.c . ) , dibekacin ( 85.8 p.c . ) , rifamycin ( 85.71 p.c . ) . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
108,
117
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
133,
143
]
} |
it specifies a 30319 dalton 3'-aminoglycoside phosphotransferase ( aph ( 3 ' ] that mediates resistance to kanamycin and structurally related aminoglycosides , including amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
107,
116
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
142,
157
]
} |
it specifies a 30319 dalton 3'-aminoglycoside phosphotransferase ( aph ( 3 ' ] that mediates resistance to kanamycin and structurally related aminoglycosides , including amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
107,
116
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
170,
178
]
} |
oral retinoids , synthetic derivatives of vitamin a , have been used in the treatment of various dermatoses over the last decade . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
5,
14
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
42,
51
]
} |
retinoids are also effective in the treatment of papulosquamous dermatoses other than psoriasis ( i.e . inherited disorders of keratinisation ) , cutaneous t-cell lymphoma and in chemotherapy and chemoprevention of cancer . | NA | {
"id": "C0162818",
"name": "papulosquamous dermatoses",
"pos": [
49,
74
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
86,
95
]
} |
to determine the effect of corticosteroids on lipoprotein metabolism in healthy subjects , we measured lipoprotein lipid and apoprotein levels in eight normolipidemic healthy men before , during , and after administration of oral prednisone 0.35 mg/kg/d . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
46,
57
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
157,
162
]
} |
after 2 weeks of treatment there was a significant improvement in the fasting blood glucose , in the mean diurnal glucose , in glucosuria , and in glucose response to a 75-g oral glucose load in both groups . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
63,
65
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
179,
186
]
} |
the fact that there are a great many sp- and npy-immunoreactive fibers in the tenuissimus muscle , with a distribution that harmonizes with their pharmacological actions , supports the view that local release of these neuropeptides contributes significantly to microvascular regulation in skeletal muscle . | NA | {
"id": "C0027893",
"name": "npy",
"pos": [
45,
48
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
218,
231
]
} |
the addition of the sulphonylurea agent , glibenclamide , to the insulin therapy of six patients with insulin-dependent diabetes mellitus was studied in a double-blind cross-over trial . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
20,
33
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
42,
55
]
} |
the diagnosis of a brainstem tumour , which presented as progressive bulbar palsy that resembled motor-neuron disease , was suspected because of the rare electromyographic finding of myokymia of the tongue , and was confirmed by magnetic resonance imaging . | NA | {
"id": "C0030442",
"name": "progressive bulbar palsy",
"pos": [
57,
81
]
} | {
"id": "C0085084",
"name": "motor-neuron disease",
"pos": [
97,
117
]
} |
[ histochemical analysis of noradrenaline and adrenaline cells in the adrenal gland during hypoxic stress in relation to the time of sacrifice ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
28,
41
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
46,
56
]
} |
there were significant differences between group 1 and group 2 in preoperative daily calorie intake , serum transferrin , retinal binding protein , pre-albumin and total lymphocyte count . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
138,
145
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
152,
159
]
} |
as a result of acid output measured during infusion of dopamine alone or dopamine with domperidone in non-vagotomized or vagotomized rats , increasing effects of dopamine on acid output were depended on dopaminergic mechanism , and decreasing effects of dopamine on acid output were depended on dopaminergic mechanism in rami vagus . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
55,
63
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
295,
307
]
} |
dual-energy subtraction radiography was performed in 41 cancer patients in whom the tumor shadow was equivocal or the border of cancer infiltration was not clearly demonstrated by compression mammography , and 15 patients with benign diseases such as fibrocystic disease , cyst and fibroadenoma . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
84,
89
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
273,
277
]
} |
on the other hand , benign diseases such as fibrocystic disease and cyst could be diagnosed as such , because the tumor shadow and the irregularly concentrated image of mammary gland disappeared by the dual-energy subtraction . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
49,
53
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
114,
119
]
} |
further , studies on the relationships between receptor occupancy of muscarinic acetylcholine receptors in this tissue , measured by [ 3h ] qnb binding , and the cch-stimulated pip2 hydrolysis , mlc phosphorylation and contraction revealed that all of these responses are coupled to the m2 receptor subtype . | NA | {
"id": "C0034826",
"name": "muscarinic acetylcholine receptors",
"pos": [
69,
103
]
} | {
"id": "C0384752",
"name": "m2 receptor",
"pos": [
287,
298
]
} |
in order to identify defects in na+-ca2+ exchange and ca2+-pump systems in cardiomyopathic hearts , the activities of sarcolemmal na+-dependent ca2+ uptake , na+-induced ca2+ release , atp-dependent ca2+ uptake and ca2+-stimulated atpase were examined by employing cardiomyopathic hamsters ( um-x7.1 ) and catecholamine-induced cardiomyopathy produced by injecting isoproterenol into rats . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
306,
319
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
365,
378
]
} |
the paper considers some aspects of the processing of precursors of foreign proteins , their interaction with the secretory system , directed changes of protein compartmentalization , and protection of foreign proteins from proteolysis . | NA | {
"id": "C0033665",
"name": "precursors",
"pos": [
54,
64
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
210,
218
]
} |
[ isolation and characteristics of antibodies against synthetic fragments of oncoproteins . ii . antiserum against the transforming protein pp60src of rous sarcoma virus ] . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
35,
45
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
97,
106
]
} |
in contrast to tbr serum , antibodies , generated against synthetic peptide , corresponding 415-421 sequence of pp60src could n't be phosphorylated in vitro , when [ gamma-32p ] atp is added to the immune complex . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
198,
212
]
} |
the antipeptide antibodies , bound to pp60src did not block phosphorylation of tbr immunoglobulins , added to this immune complex . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
16,
26
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
115,
129
]
} |
digestion of dna of two species c. undulatus and c. fulvus by 10 of the 16 restriction endonucleases used led to formation of electrophoretically discrete fragments that are multiple to 330 b.p . in length which points out the tandem organization of repetitive sequences similar to the satellite dna of many mammal species . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
13,
16
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
286,
299
]
} |
comparison has been made of the proton magnetic resonance ( pmr ) spectra of translating ribosomes in the pre-translocation and post-translocation states as well as of the complexes of translating ribosomes with elongation factors tu ( ef-tu ) or g ( ef-g ) in the presence of the uncleavable analogue of gtp -- guanylyl-imidodiphosphate ( gmp-pnp ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
305,
308
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
340,
347
]
} |
among all the known dna-binding chromosomal protein factors which are capable of specific interaction with certain nucleotide sequences , nf-i compels a particular attention as the first example of a conservative multifunctional factor being involved in the assembly of nuclease-hypersensitive chromatin structure within regulatory regions of active genes , in the trans-activation of rna polymerase ii transcription , and also in the replication of the adenoviral genome and presumably in the replication of some other dnas including the cellular one . | NA | {
"id": "C0012940",
"name": "dna-binding",
"pos": [
20,
31
]
} | {
"id": "C0069116",
"name": "nf-i",
"pos": [
138,
142
]
} |
the interaction of ethidium bromide ( etbr ) with double helical synthetic polyribonucleotides poly ( g ) .poly ( c ) , poly ( a ) .poly ( u ) and poly ( i ) .poly ( c ) has been investigated by the method of isothermal microcalorimetry and according to the character of changes on the spectra of circular dichroism , absorption and fluorescence at binding . | NA | {
"id": "C0032590",
"name": "polyribonucleotides",
"pos": [
75,
94
]
} | {
"id": "C0032411",
"name": "poly ( g",
"pos": [
95,
103
]
} |
the interaction of ethidium bromide ( etbr ) with double helical synthetic polyribonucleotides poly ( g ) .poly ( c ) , poly ( a ) .poly ( u ) and poly ( i ) .poly ( c ) has been investigated by the method of isothermal microcalorimetry and according to the character of changes on the spectra of circular dichroism , absorption and fluorescence at binding . | NA | {
"id": "C0032590",
"name": "polyribonucleotides",
"pos": [
75,
94
]
} | {
"id": "C0032400",
"name": "poly ( a",
"pos": [
120,
128
]
} |
the obtained data on spectral-energetic parameters of protein tryptophanyls and chl e6 permitted us to calculate the energy transfer critical distances r0 in complexes of chl e6 with hsa ( r0 = 32 a ) and bsa ( r0 = 35a ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
54,
61
]
} | {
"id": "C0001924",
"name": "bsa",
"pos": [
205,
208
]
} |
the binding constants ( k ) and the number of binding sites ( n ) of chl e6 with hsa and bsa have been obtained from the experiments on tryptophanyl fluorescence quenching of the investigated proteins and polarization measurements of pigment emission ( khsa = 1.2.10 ( 6 ) mole-1 , kbsa = 3.6.10 ( 6 ) mole-1 , nhsa = nbsa = 1 ) . | NA | {
"id": "C0001924",
"name": "bsa",
"pos": [
89,
92
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
192,
200
]
} |
using mutant c-myc proteins and proteins that fuse portions of c-myc to chicken muscle pyruvate kinase , we found that residues 320 to 328 ( paakrvkld ; peptide m1 ) induced complete nuclear localization , and their removal from c-myc resulted in mutant proteins that distributed in both the nucleus and cytoplasm but retained rat embryo cell cotransforming activity . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
19,
27
]
} | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
247,
262
]
} |
in developing cells disaggregated in the presence of cyclic amp , the poly ( a ) + mrna population turned over with an apparent half-life of 4 h , individual mrna decay rates were heterogeneous , and some prestalk and prespore mrnas appeared to decay with biphasic kinetics . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
128,
137
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
265,
273
]
} |
immunoprecipitation of grp78-bip induced by glucose starvation and a temperature-sensitive mutation in a hamster fibroblast cell line demonstrated the association of grp78-bip with other cellular proteins . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
113,
123
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
187,
195
]
} |
the mx- phenotype of the mx rflp type 3 strain cba/j is due to a point mutation that converts the lysine codon in position 389 to a termination codon . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
105,
110
]
} | {
"id": "C0242611",
"name": "termination codon",
"pos": [
132,
149
]
} |
from these results we conclude : 1 ) in a receptor deficient cell line ( 235-1 ) both c-erba subtypes act as hormone-dependent modulators of prl gene expression and hence function as thyroid hormone receptors , 2 ) in two different receptor containing cell lines ( gh4c1 and gh1 ) , both c-erba proteins act in a hormone-independent fashion to regulate prl and gh expression . | NA | {
"id": "C0034843",
"name": "thyroid hormone",
"pos": [
183,
198
]
} | {
"id": "C0293624",
"name": "c-erba proteins",
"pos": [
288,
303
]
} |
when vitamin d-deficient rats were supplemented for 10 days with calcium ( 3 % calcium gluconate in the water , 2 % calcium in the diet ) serum calcium levels were similar to the levels observed in the 1,25- ( oh ) 2d3-treated rats . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
65,
72
]
} | {
"id": "C0006699",
"name": "calcium gluconate",
"pos": [
79,
96
]
} |
preincubation for 5 min with dopamine did not affect the ability of a 30-sec incubation with trh to stimulate the accumulation of inositol phosphate , inositol bisphosphate , and inositol trisphosphate , either in medium containing 1.8 mm ca2+ , or in low ca2+-containing medium . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
130,
148
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
179,
187
]
} |
molecular cloning of complementary deoxyribonucleic acid for an androgen-regulated epididymal protein : sequence homology with metalloproteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
94,
101
]
} | {
"id": "C0025544",
"name": "metalloproteins",
"pos": [
127,
142
]
} |
human c-reactive protein ( crp ) is an acute phase reactant that is selectively deposited at sites of tissue damage . | NA | {
"id": "C0006560",
"name": "crp",
"pos": [
27,
30
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
39,
59
]
} |
hla-dr antigens , purified by affinity to 21w4 igg sepharose , can be precipitated with 44h10 mab , indicating that both antibodies react with the same molecules . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
94,
97
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
121,
131
]
} |
using the specific-locus method , the ability of 1-ethyl-1-nitrosourea ( enu ) and procarbazine hydrochloride ( procarbazine ) to induce gene mutations in mouse oocytes was tested and confirmed . | NA | {
"id": "C0205909",
"name": "procarbazine hydrochloride",
"pos": [
83,
109
]
} | {
"id": "C0033223",
"name": "procarbazine",
"pos": [
112,
124
]
} |
as model-mutagens were used : the nitrosamines dimethylnitrosamine ( dmn ) and diethylnitrosamine ( den ) , the triazenes 1- ( 2,4,6-trichlorophenyl ) -3,3-dimethyltriazene ( cl3pdmt ) , 1- ( 3-pyridyl ) -3,3-dimethyltriazene ( pydmt ) and dacarbazine ( dtic ) , the hydrazines procarbazine ( pcz ) , 1,1-dimethylhydrazine ( 1,1-dmh ) and 1,2-dimethylhydrazine ( 1,2-dmh ) as well as the pyrrolizidine alkaloid seniciphylline ( sph ) . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
34,
46
]
} | {
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
47,
66
]
} |
as model-mutagens were used : the nitrosamines dimethylnitrosamine ( dmn ) and diethylnitrosamine ( den ) , the triazenes 1- ( 2,4,6-trichlorophenyl ) -3,3-dimethyltriazene ( cl3pdmt ) , 1- ( 3-pyridyl ) -3,3-dimethyltriazene ( pydmt ) and dacarbazine ( dtic ) , the hydrazines procarbazine ( pcz ) , 1,1-dimethylhydrazine ( 1,1-dmh ) and 1,2-dimethylhydrazine ( 1,2-dmh ) as well as the pyrrolizidine alkaloid seniciphylline ( sph ) . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
34,
46
]
} | {
"id": "C0012200",
"name": "diethylnitrosamine",
"pos": [
79,
97
]
} |
the properties of inwardly rectifying potassium channels and of calcium-activated potassium channels in patches detached from such vesicles are shown to be consistent with expectations based on earlier studies on intact muscle fibers and with patch clamp results on the same type of channels in other tissues . | NA | {
"id": "C0032824",
"name": "potassium channels",
"pos": [
38,
56
]
} | {
"id": "C0949653",
"name": "calcium-activated potassium",
"pos": [
64,
91
]
} |
the salvage pathway enzyme , uridine phosphorylase ( pyrimidine nucleoside phosphorylase ) was purified to apparent homogeneity from g. lamblia crude extracts by fast protein liquid chromatography and gel filtration on a superose 12 column , resulting in an overall 3500 fold purification and a recovery of 7.5 % . | NA | {
"id": "C0042006",
"name": "uridine phosphorylase",
"pos": [
29,
50
]
} | {
"id": "C0072728",
"name": "pyrimidine",
"pos": [
53,
63
]
} |
in the reverse ( anabolic ) direction , the enzyme could use both uracil and thymine as substrates . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
66,
72
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
77,
84
]
} |
antibodies were affinity purified from crude antiserum by elution from the 24 kda region of preparative one-dimensional western blots containing immobilized adult schistosoma mansoni inner bilayer membrane proteins . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
45,
54
]
} |
both extracts reacted with dim-229 in an indirect enzyme-linked immunosorbent assay , indicating retention of antigenic reactivity of the solubilized epitope . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
110,
119
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
150,
157
]
} |
involvement of protein phosphorylation in ltp has been widely proposed , with protein kinase c ( pkc ) and calcium-calmodulin kinase type ii ( camkii ) as leading candidates . | NA | {
"id": "C0006776",
"name": "calmodulin kinase",
"pos": [
115,
132
]
} | {
"id": "C0248868",
"name": "camkii",
"pos": [
143,
149
]
} |
a disulphide-bonded peptide pair , designed to mimic the first crucial intermediate in the folding of bovine pancreatic trypsin inhibitor , contains secondary and tertiary structure similar to that found in the native protein . | NA | {
"id": "C0003641",
"name": "bovine",
"pos": [
102,
108
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
218,
225
]
} |
an escherichia coli isoleucine transfer rna specific for the codon aua ( trna ( 2ile ) or trna ( minorile ] has a novel modified nucleoside , lysidine in the first position of the anticodon ( position 34 ) , which is essential for the specific recognition of the codon aua . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
31,
43
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
180,
189
]
} |
patch-clamp recordings were used to study the activation of ion channels in the cell membrane of cultured embryonic chick myotubes treated with the specific activator of protein kinase c , the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ; 1 x 10 ( -7 ) m ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
193,
206
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
207,
244
]
} |
this increase in heart rate was diminished dose-dependently by the concomitant infusion of the angiotensin ii analogue saralasin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
95,
109
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
119,
128
]
} |
recently it has been reported that some dihydropyridine calcium channel antagonists ( nifedipine , nimodipine , nitrendipine ) are able to produce positive inotropic effects in isolated perfused guinea pig hearts . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel",
"pos": [
40,
71
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
86,
96
]
} |
recently it has been reported that some dihydropyridine calcium channel antagonists ( nifedipine , nimodipine , nitrendipine ) are able to produce positive inotropic effects in isolated perfused guinea pig hearts . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel",
"pos": [
40,
71
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
99,
109
]
} |
limited proteolysis increased the hydrophilicity ( bt greater than be greater than s ) in hydrophobic interaction hplc , and anionic behaviour ( bc greater than be greater than bt greater than s ) in deae ion exchanger hplc . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
125,
132
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
205,
208
]
} |
age-related changes of the components of the glutathione system ( reduced and oxidized glutathione ) were evaluated in forebrains from male wistar rats aged 5 , 10 , 15 , 20 , 25 , 30 and 35 months . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
45,
56
]
} | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
78,
98
]
} |
thus , neurokinin a shows a spectrum of antidipsogenic activity clearly different from that of substance p , the other mammalian tachykinin so far tested on drinking behaviour in the rat , which appears to be a non-selective antidipsogenic agent . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
7,
19
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
129,
139
]
} |
thus , neurokinin a shows a spectrum of antidipsogenic activity clearly different from that of substance p , the other mammalian tachykinin so far tested on drinking behaviour in the rat , which appears to be a non-selective antidipsogenic agent . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
95,
106
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
129,
139
]
} |
the antagonistic effects of beta-endorphin- ( 1-27 ) on the analgesia induced by beta-endorphin ( epsilon-opioid receptor agonist ) , d-ala2-nmephe4-gly-ol-enkephalin ( dago ) and morphine , ( mu-opioid receptor agonists ) , d-pen2-d-pen5-enkephalin ( dpdpe ) and d-ala2-d-leu5-enkephalin ( dadle ) ( delta-opioid receptor agonists ) and u-50 , 488h ( kappa-opioid receptor agonist ) were studied . beta-endorphin- ( 1-27 ) injected intraventricularly , at doses which , when injected alone did not produce analgesia , antagonized the analgesia induced by beta-endorphin given intraventricularly . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
169,
173
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
278,
288
]
} |
the antagonistic effects of beta-endorphin- ( 1-27 ) on the analgesia induced by beta-endorphin ( epsilon-opioid receptor agonist ) , d-ala2-nmephe4-gly-ol-enkephalin ( dago ) and morphine , ( mu-opioid receptor agonists ) , d-pen2-d-pen5-enkephalin ( dpdpe ) and d-ala2-d-leu5-enkephalin ( dadle ) ( delta-opioid receptor agonists ) and u-50 , 488h ( kappa-opioid receptor agonist ) were studied . beta-endorphin- ( 1-27 ) injected intraventricularly , at doses which , when injected alone did not produce analgesia , antagonized the analgesia induced by beta-endorphin given intraventricularly . | NA | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
252,
257
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
278,
288
]
} |
the rate of hydrolysis of met-enkephalin and leu-enkephalin was higher than the rate of hydrolysis of ecps containing 7 to 13 aminoacid residues . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
26,
40
]
} | {
"id": "C0014298",
"name": "ecps",
"pos": [
102,
106
]
} |
the rate of hydrolysis of met-enkephalin and leu-enkephalin was higher than the rate of hydrolysis of ecps containing 7 to 13 aminoacid residues . | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
45,
59
]
} | {
"id": "C0014298",
"name": "ecps",
"pos": [
102,
106
]
} |
in the present study , we compared the effects of the selective mu agonist , [ d-ala2-n-methyl-phe4-gly-ol ] -enkephalon ( dago ) , and the selective delta agonist , [ d-pen2,5 ] -enkephalin ( dpdpe ) , on kainic acid-induced neurotoxicity in rats . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
123,
127
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
180,
190
]
} |
in the present study , we compared the effects of the selective mu agonist , [ d-ala2-n-methyl-phe4-gly-ol ] -enkephalon ( dago ) , and the selective delta agonist , [ d-pen2,5 ] -enkephalin ( dpdpe ) , on kainic acid-induced neurotoxicity in rats . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
180,
190
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
193,
198
]
} |
the aim of the study was to document the value of p-erg regarding diagnosis and prognosis of four types of optic neuropathy : optic neuritis , compressive or hereditary optic atrophy , and traumatic optic neuropathy . | NA | {
"id": "C0029132",
"name": "optic neuropathy",
"pos": [
107,
123
]
} | {
"id": "C0029134",
"name": "optic neuritis",
"pos": [
126,
140
]
} |
brainstem auditory evoked potentials ( baeps ) were recorded from rats before and after injection with apamin , a polypeptide component of bee venom . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
103,
109
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
139,
148
]
} |
2-hydroxy-saclofen ( 2-oh-s ) , a sulphonic analogue of baclofen , slightly increased the twitch height and reversibly antagonised the gaba- and baclofen-induced depression of twitch contractions in the guinea pig vas deferens and isolated ileum , causing a parallel dextral shift in the baclofen dose-response curve in a competitive manner ( pa2 = 5.0 ) in the latter tissue . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
135,
139
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
288,
296
]
} |
wheat germ agglutinin-horseradish peroxidase conjugate ( wga-hrp ) , horseradish peroxidase ( hrp ) , and fluorogold injections were made into the spinal cord segments l4-s2 , and hrp was applied to cut l6 and s1 dorsal roots in the rat . | NA | {
"id": "C0078473",
"name": "wheat germ agglutinin-horseradish peroxidase conjugate",
"pos": [
0,
54
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
180,
183
]
} |
the average size of the ectopic gestation was 3.9 cm , the average amount of hemoperitoneum was 168 ml , the average additional blood loss attributable to the procedure was 30 ml , and the average drop in hematocrit postoperatively was 4.7 % . | NA | {
"id": "C0019065",
"name": "hemoperitoneum",
"pos": [
77,
91
]
} | {
"id": "C0019080",
"name": "blood loss",
"pos": [
128,
138
]
} |
at an e : t ratio of 50:1 , 86 +/- 16 , 85 +/- 16 , and 67 +/- 13 % inhibition was observed in 6647 , 5838 , and a4573 cells , respectively , as compared to 17 +/- 10 , 19 +/- 15 , and 29 +/- 11 % cytolysis by fresh uninduced pbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
226,
230
]
} |
vitamin e ( dl-alpha-tocopherol acetate ) can inhibit collagen production in rabbit corneal keratocytes in vitro when incubated in the absence of serum . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
0,
9
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopherol acetate",
"pos": [
12,
39
]
} |
cell growth is not appreciably affected but fibronectin synthesis is increased after exposure to vitamin e ( dl-alpha-tocopherol and dl-alpha-tocopherol acetate ) in the absence of serum . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
97,
106
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopherol acetate",
"pos": [
133,
160
]
} |
reduced and oxidized glutathione ( gsh gssg ) levels in rbc were similar among the three groups . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
35,
38
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
39,
43
]
} |
in this osteopathy a decoupling of the remodeling process has to be assumed : it is thought that other , still unknown , factors maintain regular bone formation although there is little or no bone resorption . | NA | {
"id": "C0005940",
"name": "osteopathy",
"pos": [
8,
18
]
} | {
"id": "C0005974",
"name": "bone",
"pos": [
192,
196
]
} |
in this article , the diagnosis and treatment of gastroesophageal reflux ( ger ) , esophageal primary dysmotilities , and esophageal infections were reviewed . | NA | {
"id": "C0017168",
"name": "gastroesophageal reflux",
"pos": [
49,
72
]
} | {
"id": "C0014858",
"name": "esophageal",
"pos": [
122,
132
]
} |
activities of various cobalamins for euglena gracilis with reference to vitamin b 12 assay with euglena . | NA | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
22,
32
]
} | {
"id": "C0042845",
"name": "vitamin",
"pos": [
72,
79
]
} |
coenzyme b ( 12 ) and methylcobalamin in water are less active in promoting growth of euglena gracilis z strain than the same concentrations of cyanocobalamin and hydroxocobalamin which are equally active . | NA | {
"id": "C0065844",
"name": "water",
"pos": [
41,
46
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
144,
158
]
} |
coenzyme b ( 12 ) and methylcobalamin in water are less active in promoting growth of euglena gracilis z strain than the same concentrations of cyanocobalamin and hydroxocobalamin which are equally active . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
144,
158
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
163,
179
]
} |
the results suggest that the euglena assay using cyanocobalamin standards is not satisfactory for quantitation of coenzyme b ( 12 ) and methylcobalamin in water but acceptable when coenzyme b ( 12 ) and methylcobalamin are bound to serum or liver . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
49,
63
]
} | {
"id": "C0065844",
"name": "water",
"pos": [
155,
160
]
} |
sulphitocobalamin in water is as active as cyanocobalamin and hydroxocobalamin but nitritocobalamin is less active . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
43,
57
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
62,
78
]
} |
factor b , the monocarboxylic acids of cyanocobalamin and hydroxocobalamin , and the dicarboxylic acid of cyanocobalamin in water were inactive . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
58,
74
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
106,
120
]
} |
the interaction between the agarose gel and lipoproteins has been reduced and the separation between beta- and pre-beta-lipoproteins has been improved over existing methods . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
44,
56
]
} | {
"id": "C0023825",
"name": "pre-beta-lipoproteins",
"pos": [
111,
132
]
} |
[ therapeutic trial of an association of theophylline and proscillaridin a in the treatment of cor pulmonale and of some decompensated heart diseases ] . | NA | {
"id": "C0034072",
"name": "cor pulmonale",
"pos": [
95,
108
]
} | {
"id": "C0018799",
"name": "of",
"pos": [
113,
115
]
} |
a comparison of the effects of noradrenaline , adrenaline and some phenylephrine derivatives on alpha- , beta- and beta- adrenergic receptors . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
31,
44
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} |
the mutation apparently also affects adenosylhomocysteine uptake , but not that of the s-adenosylmethionine moieties adenine , homocysteine , homoserine , or methionine , nor the sulfonium compound , s-methylmethionine . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
97,
107
]
} | {
"id": "C0042889",
"name": "methylmethionine",
"pos": [
202,
218
]
} |
four amino acids of casein hydrolysate , dl-aspartic acid , l-glutamic acid , l-proline , and l-alanine caused formation of pigment when added individually . dl-ornithine also was effective . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
5,
16
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
94,
103
]
} |
the ability of bornane and substituted bornanes to induce the early enzymes for d ( + ) -camphor degradation and control of these enzymes by catabolite repression were studied in a strain of a pseudomonas putida . | NA | {
"id": "C0006025",
"name": "bornanes",
"pos": [
39,
47
]
} | {
"id": "C0006809",
"name": "camphor",
"pos": [
89,
96
]
} |
specific differences in membrane proteins were observed between thymidine-starved rec ( + ) and reca cells , as expected from previous experiments in which these proteins were associated with cell division and dna synthesis . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
24,
41
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
162,
170
]
} |
the effect of metopirone on the urinary excretion of testosterone and epitestosterone in normal males treated with hcg or cyproterone and in hirsute females . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
53,
65
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
70,
85
]
} |
the role of testosterone and androstenedione as precursors of epitestosterone in guinea pigs ( in vivo and in vitro studies ) . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
12,
24
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
62,
77
]
} |
certain proteins , ; the acute phase reactants ' ( orosomucoid , alpha ( 1 ) -antitrypsin , alpha ( 1 ) -antichymotrypsin , and haptoglobin ) and the immunoglobulins were clinically useful , since their serum concentration reflected the grade of activity of the disease . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
25,
36
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
51,
62
]
} |
certain proteins , ; the acute phase reactants ' ( orosomucoid , alpha ( 1 ) -antitrypsin , alpha ( 1 ) -antichymotrypsin , and haptoglobin ) and the immunoglobulins were clinically useful , since their serum concentration reflected the grade of activity of the disease . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
25,
36
]
} | {
"id": "C0002191",
"name": "alpha ( 1",
"pos": [
65,
74
]
} |
certain proteins , ; the acute phase reactants ' ( orosomucoid , alpha ( 1 ) -antitrypsin , alpha ( 1 ) -antichymotrypsin , and haptoglobin ) and the immunoglobulins were clinically useful , since their serum concentration reflected the grade of activity of the disease . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
25,
36
]
} | {
"id": "C0002190",
"name": "alpha ( 1",
"pos": [
65,
74
]
} |
certain proteins , ; the acute phase reactants ' ( orosomucoid , alpha ( 1 ) -antitrypsin , alpha ( 1 ) -antichymotrypsin , and haptoglobin ) and the immunoglobulins were clinically useful , since their serum concentration reflected the grade of activity of the disease . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
25,
36
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
128,
139
]
} |
a pronounced elevation of haptoglobin compared with that of the other ; acute phase reactants ' was present in patients with crohn 's disease complicated by suppurative fistulas or abscesses . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
26,
37
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
72,
93
]
} |
experiments on the liberation of phosphate from the muscles of the human forearm during vigorous exercise and on the action of sodium phosphate on forearm muscle blood vessels . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
33,
42
]
} | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
127,
143
]
} |
infusions of sodium phosphate into the brachial artery which raised plasma phosphate in the venous effluent from the resting muscles by 400 % had no effect upon the rate of the forearm blood flow.4 . | NA | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
13,
29
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
75,
84
]
} |
the effect of hexoses and of the anions chloride , thiocyanate , and salicylate on the permeability of human red cells to [ ( 14 ) c ] erythritol has been studied.2 . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
33,
39
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
40,
48
]
} |
it was confirmed that erythritol competes with glucose , mannose , and galactose for the hexose transfer system of the red cell membrane . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
47,
54
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
89,
95
]
} |
it was confirmed that erythritol competes with glucose , mannose , and galactose for the hexose transfer system of the red cell membrane . | NA | {
"id": "C0024742",
"name": "mannose",
"pos": [
57,
64
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
89,
95
]
} |
it was confirmed that erythritol competes with glucose , mannose , and galactose for the hexose transfer system of the red cell membrane . | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
71,
80
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
89,
95
]
} |
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