text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these data suggest that phosphorylase activity in muscle cultured from patients with mcardle disease is due to a fetal isoenzyme whose genetic control is different from that of the mature enzyme . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
119,
128
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
188,
194
]
} |
antiviral activity of the complexes of synthetic polyribonucleotides , i.e . poly ( i ) .poly ( c ) and poly ( g ) .poly ( c ) obtained at non-equimolar ratios of homopolymers was studied . | NA | {
"id": "C0032590",
"name": "polyribonucleotides",
"pos": [
49,
68
]
} | {
"id": "C0032411",
"name": "poly",
"pos": [
167,
171
]
} |
the wine yeasts cheres were not sensitive to high concentration ( 500 gamma/ml ) of benzylpenicillin , streptomycin , tetracycline , oxytetracycline , chlortetracycline , morphocycline , erythromycin , oleandomycin , monomycin , neomycin , kanamycin , polymyxin , ampicillin , oxacillin , methicillin , ceporin , ristomycin , levomycetin , furadonin and furazolidone . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
84,
100
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
264,
274
]
} |
benzylpenicillin , polymyxin , neomycin and ampicillin in concentrations of 50 to 100 gamma/ml had a stimulating effect on the yeast biomass synthesis . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
0,
16
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
44,
54
]
} |
higher toxicity of carfecillin as compared to carbenicillin may be due to production of free phenol on carfecillin hydrolysin in the animal organism . | NA | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
46,
59
]
} | {
"id": "C0007241",
"name": "carfecillin",
"pos": [
103,
114
]
} |
only trace quantities of these acids were produced in a medium that contained a mixture of amino acids that did not include the branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
91,
102
]
} | {
"id": "C0002521",
"name": "branched-chain amino",
"pos": [
128,
148
]
} |
the cis and trans isomers of zearalenone [ 2,4-dihyroxy-6- ( 10-hydroxy-6-oxo-1-undecenyl ) -benzoic acid mu-lactone ] and zearalenol [ 2,4-dihydroxy-6- ( 6,10-dihydroxy-1-undecenyl ) -benzoic acid mu-lactone ] were tested for uterotropic activity in the white rat . | NA | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
29,
40
]
} | {
"id": "C0022947",
"name": "lactone",
"pos": [
201,
208
]
} |
it is shown that daily oral administration of 5 -- 10 mg of an antidiabetic biguanide-phenformin ( phenethyl-biguanide ) for 2.5 -- 5 months suppressed dmba-induced mammary tumour development in rats considerably . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
76,
85
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
86,
96
]
} |
fragmentation and degeneration of the elastic laminae of muscular arteries was followed by vascular calcification that could not be distinguished morphologically from monckeberg 's arteriosclerosis . | NA | {
"id": "C0342649",
"name": "vascular calcification",
"pos": [
91,
113
]
} | {
"id": "C0887866",
"name": "monckeberg 's arteriosclerosis",
"pos": [
167,
197
]
} |
it is suggested that the selective accumulation of salicylates in the parietal cells may account for the specific cytotoxic actions of aspirin on these cells . | NA | {
"id": "C0036077",
"name": "salicylates",
"pos": [
51,
62
]
} | {
"id": "C0004057",
"name": "aspirin",
"pos": [
135,
142
]
} |
when used in conjunction with timolol , other adrenergic amines , such as norepinephrine and epinephrine , produce an additional hypotensive response . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
74,
88
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
pathophysiology and tomography of the blood vessels of the posterior cranial fossa gain clinical interest in treatment of diseases of the inner ear , complications of middle ear inflammations , tumors of the pyramid and cerebello-pontine angle . | NA | {
"id": "C0013447",
"name": "of diseases",
"pos": [
119,
130
]
} | {
"id": "C0029877",
"name": "of",
"pos": [
201,
203
]
} |
physiological measurements consisted of heart rate and urine biochemical analysis for 17-ketogenic steroids , epinephrine , and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
128,
142
]
} |
at sacrifice , variations in heart weight were evaluated relative to sex , initial body weight , relative change in body weight and level of treatment . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
35,
41
]
} | {
"id": "C0005911",
"name": "change in",
"pos": [
106,
115
]
} |
both enzymes hydrolysed other short-chain acyl-coa compounds and succinyl-coa ( 3-carboxypropionyl-coa ) , but with one acetyl-coa was the preferred substrate . | NA | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
42,
50
]
} | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
120,
130
]
} |
rrna from detergent-purified nuclei was fractionated quantitatively , by two independent methods , into nucleolar and nucleoplasmic rna fractions . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
0,
4
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
132,
135
]
} |
the two rna fractions were analysed by urea/agar-gel electrophoresis and the amount of pre-rrna ( precursor of rrna ) and rrna components was determined . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
8,
11
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
122,
126
]
} |
the rrna constitutes 35 % of total nuclear rna , of which two-thirds are in nucleolar rna and one-third in nucleoplasmic rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
4,
8
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
121,
124
]
} |
the rrna constitutes 35 % of total nuclear rna , of which two-thirds are in nucleolar rna and one-third in nucleoplasmic rna . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
35,
46
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
121,
124
]
} |
the bulk of rrna in nucleoplasmic rna is represented by 28 s and 18 s rrna in a molar ratio close to 1.0 . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
13,
16
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
70,
74
]
} |
part of the mature rrna species in nucleoplasmic rna originate from ribosomes attached to the outer nuclear membrane , which resist detergent treatment . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
19,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
49,
52
]
} |
scallop troponin i was isolated and mixed with chicken troponin c and troponin t , forming a functional hybrid troponin complex , indicating that scallop and vertebrate troponins may act by a common mechanism . | NA | {
"id": "C0077401",
"name": "troponin i",
"pos": [
8,
18
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
169,
177
]
} |
scallop troponin i was isolated and mixed with chicken troponin c and troponin t , forming a functional hybrid troponin complex , indicating that scallop and vertebrate troponins may act by a common mechanism . | NA | {
"id": "C0077404",
"name": "troponin t",
"pos": [
70,
80
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
169,
177
]
} |
their amino acid compositions are very similar , both being high in aspartic acid , glutamic acid , serine , glycine and leucine , and low in methionine , tryptophan , tyrosine , isoleucine and histidine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
6,
16
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
109,
116
]
} |
the ph optimum for the enzyme was ph 7.5 , and it degraded linear-duplex dna or closed-circular-duplex dna to acid-soluble material . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
73,
76
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
87,
95
]
} |
however , dichloromethanediphosphonate stopped the growth of the calvaria cells and the fibroblasts after the beginning of confluence , whereas the untreated cells were still growing to a certain extent . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
88,
99
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
radioactive dichloromethanediphosphonate and 1-hydroxyethane-1,1-diphosphonate were taken up linearly with time for at least 48 h by calvaria cells and fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
152,
163
]
} |
a rapid , sensitive fluorometric method for the determination of ajmaline and n-propylajmaline ( npa ) was used to follow serum concentrations after an i.v . administration of ajmaline , after an oral administration of ajmaline , and an oral dose of npa bitartrate ( npab ) in beagle dogs . | NA | {
"id": "C0001888",
"name": "ajmaline",
"pos": [
65,
73
]
} | {
"id": "C0032899",
"name": "npa",
"pos": [
267,
270
]
} |
ajmaline was eliminated from serum with an apparent half-life of approximately 1 h and npa with one of approximately 4 h . | NA | {
"id": "C0001888",
"name": "ajmaline",
"pos": [
0,
8
]
} | {
"id": "C0032899",
"name": "npa",
"pos": [
87,
90
]
} |
the peak serum concentrations of ajmaline and npa after a single oral dose of 50 mg of ajmaline and npab were about 1.4 microgram/ml and 0.6 microgram/ml , respectively , the latter calculated as its bitartrate , with about the same peak time : 1 h . | NA | {
"id": "C0032899",
"name": "npa",
"pos": [
46,
49
]
} | {
"id": "C0001888",
"name": "ajmaline",
"pos": [
87,
95
]
} |
in rabbits undergoing active-passive immunization , the appearance time of endogenous antibodies is delayed , all the more so as the antiserum injected dose increases . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
86,
96
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
133,
142
]
} |
owing to the close relationship between ionizing raditions and chromosome aberrations on one hand , and abnormal karyotypes and tumors on the other , it can not be overlooked that these aberrations may play an important role , together with other carcinogenic factors , in the development of second malignancies in these patients . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
128,
134
]
} | {
"id": "C0085183",
"name": "second malignancies",
"pos": [
292,
311
]
} |
chronological endocrine changes accompanying various diseases in the hypothalamo-pituitary region ( 183 cases ) were collectively studied by evaluating both endocrinological symptoms and anterior pituitary functions , with the following results : 1 ) endocrine disorders following the operation , trauma and subarachnoideal hemorrhage in the pituitary-diencephalic region varied in the order of a ) subclinical , b ) clinical and c ) paradoxical . | NA | {
"id": "C0032002",
"name": "diseases",
"pos": [
53,
61
]
} | {
"id": "C0014130",
"name": "endocrine disorders",
"pos": [
251,
270
]
} |
4 ) the endocrine disorder developed and exacerbated in 6 months to 2 years after radio therapy of the pituitary-diencephalic region . | NA | {
"id": "C0014130",
"name": "endocrine disorder",
"pos": [
8,
26
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
103,
112
]
} |
spleen cells from adult mice which had been thymectomized 8 weeks previously demonstrated a severely impaired primary cytotoxic response to p815 tumour cells , whereas their cytotoxic responses to allogeneic cells ( c57bl/6 ) and to non-h-2 antigens ( balb/c ) , and their ability to form a primary antibody response to sheep red blood cells was unimpaired . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
197,
213
]
} |
the salient features of this method for biological monitoring of occupational exposure to organophosphorus insecticides are : ( a ) acetylcholinesterase ( ache ) and butyrylcholinesterase ( buche ) are determined separately in whole haemolysed blood using specific substrates at appropriate concentrations ; | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
132,
152
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
166,
187
]
} |
apart from isolated ectopic beats , disturbances of rhythm were uncommon , and neither vpb nor other arrhythmias appeared to be induced by occupational factors . | NA | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
20,
33
]
} | {
"id": "C0151636",
"name": "vpb",
"pos": [
87,
90
]
} |
apart from isolated ectopic beats , disturbances of rhythm were uncommon , and neither vpb nor other arrhythmias appeared to be induced by occupational factors . | NA | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
20,
33
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
101,
112
]
} |
the effect of long-term application of 4 % atenolol eye drops has been studied in patients with either glaucoma or ocular hypertension . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
103,
111
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
115,
134
]
} |
the addition of h2o2 to superoxide dismutase reduces the copper to cu ( i ) , while oxygen addition to the peroxide-reduced protein restores the copper to cu ( ii ) . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
16,
20
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
107,
115
]
} |
analogue binding to egg white binding apoprotein has been quantitated and serves to determine the origins of binding site specificity for this protein . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
38,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
143,
150
]
} |
this suggests a common mechanism for the reactions of such diverse flavins as riboflavin , 5-deazariboflavin , and 1-deazariboflavin . | NA | {
"id": "C0016213",
"name": "flavins",
"pos": [
67,
74
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
122,
132
]
} |
the interactions of 4-nitroquinoline 1-oxide ( nqo ) with the four 5'-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and 1h and 13c nuclear magnetic resonance ( nmr ) spectra of nucleotide-nqo mixtures . | NA | {
"id": "C0011529",
"name": "deoxyribonucleotides",
"pos": [
70,
90
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
218,
228
]
} |
furthermore , we conclude that the interactions of polymerase with ss dna are , in general , stronger than the nonspecific interations of the enzyme with ds dna . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
67,
73
]
} | {
"id": "C0012854",
"name": "ds dna",
"pos": [
154,
160
]
} |
such spectra have been recorded in aqueous solutions under conditions allowing a study of the exchangeable proton resonances of histone complexes for the first time and indicate that the structured regions are rich in hydrophobic amino acids , as well as arginine and some acidic amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
230,
241
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
273,
291
]
} |
transfer of anionic liposomes prepared at a given ph to a solution of different ph resulted in a ph gradient if sodium phosphate or borate were used as buffers . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
12,
19
]
} | {
"id": "C0006007",
"name": "borate",
"pos": [
132,
138
]
} |
( 2 ) the antibiotics rutamycin , dio-9 , quercetin , oligomycin , botrycidin , efrapeptin , leucinostatin , valinomycin , and venturicidin as well as n , n'-dicyclohexylcarbodiimide and dinitrophenol are potent inhibitors of f0.f1atpase activity . ( 3 ) f0.f1atpase activity is completely inhibited by anti-f1atpase antibodies . | NA | {
"id": "C0035972",
"name": "rutamycin",
"pos": [
22,
31
]
} | {
"id": "C0028951",
"name": "oligomycin",
"pos": [
54,
64
]
} |
a method is presented for the separation of 6-thiopurine bases and ribonucleosides , of sulphate anions and of common purine bases and oxidized purines by means of high-pressure liquid cation-exchange chromatography using a 0.18 x 100 cm column , filled with beckman m71 resin , and eluted with 0.4m ammonium formate , ph 4.6 , at a linear flow velocity of 5.2 cm/min at 50 degrees c . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
88,
96
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
97,
103
]
} |
it was determined that of six tetracyclines tested , four strongly inhibited the reaction ( oxytetracycline , chlorotetracycline , dedimethylaminotetracycline , and tetracycline ) whereas 5a,6-anhydrotetracycline gave a moderate inhibition and alpha-6-deoxyoxytetracycline resulted in only a slight reduction in ppgpp synthesis . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
30,
43
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
257,
272
]
} |
it was determined that of six tetracyclines tested , four strongly inhibited the reaction ( oxytetracycline , chlorotetracycline , dedimethylaminotetracycline , and tetracycline ) whereas 5a,6-anhydrotetracycline gave a moderate inhibition and alpha-6-deoxyoxytetracycline resulted in only a slight reduction in ppgpp synthesis . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
30,
43
]
} | {
"id": "C0008293",
"name": "chlorotetracycline",
"pos": [
110,
128
]
} |
it was determined that of six tetracyclines tested , four strongly inhibited the reaction ( oxytetracycline , chlorotetracycline , dedimethylaminotetracycline , and tetracycline ) whereas 5a,6-anhydrotetracycline gave a moderate inhibition and alpha-6-deoxyoxytetracycline resulted in only a slight reduction in ppgpp synthesis . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
30,
43
]
} | {
"id": "C0013090",
"name": "alpha-6-deoxyoxytetracycline",
"pos": [
244,
272
]
} |
at this ionic strength the secondary structure of double-stranded rna is maintained , as judged by the following : ( a ) the unchanged resistance of double-stranded rna and dna , under similar low ionic strength conditions , to nuclease s1 from aspergillus oryzae , in contrast with the sensitivity of the corresponding denatured nucleic acids to this enzyme , specific for single-stranded rna and dna ; | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
330,
343
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
398,
401
]
} |
whereas in ssc bovine seminal rnaase ( rnaase bs-1 ) and whale pancreatic rnaase show an activity on double-stranded rna significantly higher than that of rnaase a , in 0.1 x ssc the activity of the latter enzyme on this substrate becomes distinctly higher than that of rnaase bs-1 , and similar to that of whale rnaase . | NA | {
"id": "C0035541",
"name": "pancreatic rnaase",
"pos": [
63,
80
]
} | {
"id": "C0014241",
"name": "rnaase",
"pos": [
313,
319
]
} |
these oligonucleotides were fractionated first be deae-cellulose chromatography with 7 m urea into the respective isoplithic groups and then analysed for the composition and isomerism : each group was labeled 5'-terminally by the [ gamma-32p ] atp-polynucleotide kinase reaction and then electrophoresed monodimensionally for the dinucleotides and two-dimensionally for the di- and trinucleotides mixtures , respectively , followed by elution and digestion with snake venom exonuclease . | NA | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
6,
22
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
248,
262
]
} |
these included a reduction in the amounts of adenosine and 3- ( 3-amino-3-carboxypropyl ) -uridine , and an increase in the amounts of 1-methyl-adenosine , 1-methylguanosine , 3-methylcytidine and pseudouridine . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
91,
98
]
} | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
197,
210
]
} |
as compared to 8-methoxypsoralen , a well-known bifunctional furocoumarin , 3-carbethoxypsoralen exhibits a high photoaffinity for dna in vivo . | NA | {
"id": "C0025684",
"name": "8-methoxypsoralen",
"pos": [
15,
32
]
} | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
61,
73
]
} |
the time required for one translocation by all active ribosomes , and the time required for the incorporation of one amino acid ( starting with aminoacyl-trna or amino acids ) has also been determined . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
144,
158
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
162,
173
]
} |
the amino acid composition of hydrogenase preparations from different fractions of t. roseopersicina is identical , glycine and alanine as n-terminal amino acid residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
116,
123
]
} |
the amino acid composition of hydrogenase preparations from different fractions of t. roseopersicina is identical , glycine and alanine as n-terminal amino acid residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
128,
135
]
} |
an increased low km cyclic amp phosphodiesterase activity was found upon exposure of intact fibroblasts to 3-isobutyl-1-methylxanthine , an inhibitor of phosphodiesterase activity in broken cell preparations , as well as to other agents which elevate cyclic amp levels in these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
278,
283
]
} |
form b2 is the major form of the aromatic-amino-acid aminotransferase ( aromatic-amino-acid:2-oxoglutarate amino-transferase , ec 2.6.1.57 ) and the km values of tyrosine and phenylalanine with this form are somewhat lower than with the minor form a . | NA | {
"id": "C0301713",
"name": "aromatic-amino-acid",
"pos": [
33,
52
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
162,
170
]
} |
form b2 is the major form of the aromatic-amino-acid aminotransferase ( aromatic-amino-acid:2-oxoglutarate amino-transferase , ec 2.6.1.57 ) and the km values of tyrosine and phenylalanine with this form are somewhat lower than with the minor form a . | NA | {
"id": "C0301713",
"name": "aromatic-amino-acid",
"pos": [
33,
52
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
175,
188
]
} |
the km of tyrosine with histidinol phosphate aminotransferase ( protein b1 ) is in the same range , but the km of phenylalanine with this enzyme is 12-20 times higher than the corresponding values with the two forms of the aromatic-amino-acid amino-transferase . | NA | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
10,
18
]
} | {
"id": "C0301713",
"name": "aromatic-amino-acid",
"pos": [
223,
242
]
} |
the km of tyrosine with histidinol phosphate aminotransferase ( protein b1 ) is in the same range , but the km of phenylalanine with this enzyme is 12-20 times higher than the corresponding values with the two forms of the aromatic-amino-acid amino-transferase . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
114,
127
]
} | {
"id": "C0301713",
"name": "aromatic-amino-acid",
"pos": [
223,
242
]
} |
the dehydrogenase may be of importance for the regulation of the level of endogenous prostaglandins and , thus , a decrease in activity could result in a slower turnover of prostaglandins . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
85,
99
]
} | {
"id": "C0033555",
"name": "a",
"pos": [
181,
182
]
} |
the degradation of 125i-labeled low density lipoprotein by cultured human skin fibroblasts was enhanced 25 % by preincubation of cells with insulin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
79,
90
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
proteolysis of the lipoproteins by agarose-trypsin was more rapid at 37 degrees c than at 22 degrees c , but the proteolytic products were similar and differed from the products from the lipid free proteins . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
19,
31
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
187,
192
]
} |
peptide fragments from lipoproteins were larger than those from lipid-free proteins , which suggests masking of potentially cleavable groups by lipid . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
23,
35
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
144,
149
]
} |
the amounts ( mol/g protein ) of new carboxyl-terminal tyrosine and phenylalanine released by agarose -chymotrypsin were much greater from the lipid-free proteins , but about 3/4 of the tryptophan residues were inacessible in both lipoproteins and lipid-free proteins . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
231,
243
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
248,
253
]
} |
in agarose-trypsin digestion , lysine residues were slightly more masked than arginine in the absence of lipids and much more so in the lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
105,
111
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
136,
148
]
} |
the results suggest that ldl apoprotein may be made of segments of , at least , very similar amino acid composition and that both the protein itself and derivative fragments have a great tendency to aggregate even in denaturing solvents . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
29,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
134,
141
]
} |
the large subunit of fraction 1 protein from lycopersicon esculentum , nicotiana tabacum and petunia hybrida has been examined by isoelectric focusing of the s-carboxymethylated polypeptides , and by double immunodiffusion with antiserum raised against fraction 1 protein . | NA | {
"id": "C0599220",
"name": "subunit",
"pos": [
10,
17
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
264,
271
]
} |
the ratio of the acidic amino acids and their amides ( glx plus asx ) to the basic amino acids ( lys plus arg ) was 2.2 . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
77,
94
]
} | {
"id": "C0024337",
"name": "lys",
"pos": [
97,
100
]
} |
of the other calcium-binding proteins examined , namely , troponin-c , s-100 protein , phospholipase a , phospholipase b and myosin light chain , only troponin-c displayed any significant calcium-specific binding of trifluoperazine . | NA | {
"id": "C0006732",
"name": "calcium-binding proteins",
"pos": [
13,
37
]
} | {
"id": "C0027108",
"name": "myosin light chain",
"pos": [
125,
143
]
} |
of the other calcium-binding proteins examined , namely , troponin-c , s-100 protein , phospholipase a , phospholipase b and myosin light chain , only troponin-c displayed any significant calcium-specific binding of trifluoperazine . | NA | {
"id": "C0006732",
"name": "calcium-binding proteins",
"pos": [
13,
37
]
} | {
"id": "C0077400",
"name": "troponin-c",
"pos": [
151,
161
]
} |
inhibition of the cervical cell activity by diisopropylfluorophosphate and p-nitrophenyl-p'-guanidinobenzoate demonstrates that , like urokinase and trypsin , this plasminogen activator is also a serine protease . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
149,
156
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
196,
211
]
} |
both bacteriocins like wild-type cloacin df13 , are still able to inhibit in vitro protein synthesis , but their in vivo killing activity is absent . | NA | {
"id": "C0004641",
"name": "wild-type",
"pos": [
23,
32
]
} | {
"id": "C0008988",
"name": "cloacin",
"pos": [
33,
40
]
} |
it has been shown that ca2+-atpase possesses the same mobility as skeletal muscle myosin under gel chromatography on sepharose 4b and the same mobility as myosin heavy chains in sodium dodecyl sulfate -- polyacrylamide gel electrophoresis . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
82,
88
]
} | {
"id": "C0027100",
"name": "myosin heavy chains",
"pos": [
155,
174
]
} |
comparative analysis of the lytic effect of anionic , cationic and non-ionic sac is carried out , a correlation between key physico-chemical characteristics of the agents ( critical concentration of micellization , hydrophyle-lipophyle balance ) and their lytic activity is investigated . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
44,
51
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
71,
76
]
} |
comparative analysis of the lytic effect of anionic , cationic and non-ionic sac is carried out , a correlation between key physico-chemical characteristics of the agents ( critical concentration of micellization , hydrophyle-lipophyle balance ) and their lytic activity is investigated . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
54,
62
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
71,
76
]
} |
the mg- and ca-atpase activities of the wheat embryo nuclei were found in the nuclear fraction of albumin , in nonhistone proteins and nuclear membranes . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
98,
105
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
122,
130
]
} |
in the albumin nuclear fraction and subfractions of non-histone proteins the higher level of activity is observed in ca-atpase , whereas in the nuclei and soluble fractions of residual proteins in mg-atpase . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
7,
14
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
185,
193
]
} |
the replacement of nh-group to the c-end of the angiotensin molecule by affection the antigen determinant considerably decreases the antigen activity of the analogues . | NA | {
"id": "C0003316",
"name": "antigen determinant",
"pos": [
86,
105
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
133,
140
]
} |
paramagnetism was induced in the red blood cells by oxidizing the iron atoms in the cell hemoglobin to the ferric state ( methemoglobin ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
89,
99
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
122,
135
]
} |
the endonuclease-sensitive site and tlc measurements can be reconciled by the assumption that pyrimidine dimers are excised from high molecular weight dna in acid-insoluble oligonucleotides that are slowly degraded to acid-soluble fragments . | NA | {
"id": "C0034286",
"name": "pyrimidine dimers",
"pos": [
94,
111
]
} | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
173,
189
]
} |
identification of sources of hydrogen atoms in fatty acids synthesized using deuterated water and stereospecifically deuterium labelled nadph by gas chromatographic mass spectrometric analysis . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
29,
37
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
117,
126
]
} |
precursors of the stromal fibroblasts in native cell suspensions were found to be essentially more sensitive to the cytotoxic action of afs than the colony-forming fibroblasts on the passage cultures . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
48,
52
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
[ effect of mouse antiserum against isologous aggregated immunoglobulins on the accumulation of rosette- and antibody-forming cells in mice immunized with ram erythrocytes ] . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
18,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
109,
117
]
} |
the paper describes the effect of mouse antiserum against isologous aggregated immunoglobulins ( termed maas ) on the kinetics of rosette-forming and antibody-forming cells ( rfc and afc , respectively ) in mice immunized with srbc . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
40,
49
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
150,
158
]
} |
the rate of 3h-glycine incorporation into the total proteins of the liver , those of microsomal fraction , proteins of hyaloplasm , and plasmatic membrane proteins , soluble and non-soluble in 0.05 m k2co3 , was determined . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
146,
163
]
} |
1 pretreatment of rats with intraperitoneal injections of lead was shown to result in a depression of the microsomal mixed function oxidase system , as assessed by a decrease in hepatic microsomal p-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase . | NA | {
"id": "C0003927",
"name": "microsomal mixed function oxidase",
"pos": [
106,
139
]
} | {
"id": "C0003039",
"name": "aniline hydroxylase",
"pos": [
267,
286
]
} |
1 the activity produced by the adenine nucleotides adenosine triphosphate ( atp ) , adenosine diphosphate ( adp ) and adenosine monophosphate ( amp ) and by potassium , acetylcholine ( ach ) , 5-hydroxytryptamine ( 5-ht ) and bradykinin when applied to an exposed blister base on the ear of anaesthetized rabbits or intra-arterially to anaesthetized cats was investigated in multiple strands dissected from the auricular-temporal and saphenous nerves of rabbits and cats , respectively . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
31,
50
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
51,
73
]
} |
1 the activity produced by the adenine nucleotides adenosine triphosphate ( atp ) , adenosine diphosphate ( adp ) and adenosine monophosphate ( amp ) and by potassium , acetylcholine ( ach ) , 5-hydroxytryptamine ( 5-ht ) and bradykinin when applied to an exposed blister base on the ear of anaesthetized rabbits or intra-arterially to anaesthetized cats was investigated in multiple strands dissected from the auricular-temporal and saphenous nerves of rabbits and cats , respectively . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
31,
50
]
} | {
"id": "C0001459",
"name": "adenosine diphosphate",
"pos": [
84,
105
]
} |
1 the activity produced by the adenine nucleotides adenosine triphosphate ( atp ) , adenosine diphosphate ( adp ) and adenosine monophosphate ( amp ) and by potassium , acetylcholine ( ach ) , 5-hydroxytryptamine ( 5-ht ) and bradykinin when applied to an exposed blister base on the ear of anaesthetized rabbits or intra-arterially to anaesthetized cats was investigated in multiple strands dissected from the auricular-temporal and saphenous nerves of rabbits and cats , respectively . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
31,
50
]
} | {
"id": "C0001465",
"name": "adenosine monophosphate",
"pos": [
118,
141
]
} |
the condition may present with jaundice , malabsorption or the signs and symptoms of intestinal obstruction due to internal hernia or volvulus . | NA | {
"id": "C0021843",
"name": "of intestinal obstruction",
"pos": [
82,
107
]
} | {
"id": "C0042961",
"name": "volvulus",
"pos": [
134,
142
]
} |
under the experimental conditions used , norepinephrine as well as alpha-methyl-norepinephrine were taken up in only noradrenergic and dopaminergic terminals . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} | {
"id": "C0025805",
"name": "alpha-methyl-norepinephrine",
"pos": [
67,
94
]
} |
the effects of some amino acids ( glu , gly and gaba ) , applied in 3 different manners ( electrophoretically , in the superfusate and by pressure-microinjection ) , were investigated on spontaneous and light-induced spike discharges in the isolated carp retina . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
20,
31
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
40,
43
]
} |
a microiontophoretic study was performed of the actions of angiotensin ii and angiotensin fragments on neurones of the subfornical organ ( sfo ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
59,
73
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
78,
89
]
} |
( 3 ) the involvement of other catecholaminergic systems was excluded by pretreatment of the rats with reserpine plus a-methyl-p-tyrosine which reduced the levels of na , dopamine and adrenaline in the frontal cortex with 92 , 97 and 99 % respectively . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
166,
168
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
184,
194
]
} |
serum epinephrine and norepinephrine were measured in arterial samples drawn pre-induction , post-induction , before cardiopulmonary bypass , two and eight minutes after initiation of cardiopulmonary bypass , 20 minutes before termination and after termination of cardiopulmonary bypass . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
6,
17
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
22,
36
]
} |
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