text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the following values were found for the half saturation of the transport system with hexoses at 38 degrees c : glucose 6 mm , mannose 11 mm , and galactose 40 mm.4 . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
85,
92
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
126,
133
]
} |
the following values were found for the half saturation of the transport system with hexoses at 38 degrees c : glucose 6 mm , mannose 11 mm , and galactose 40 mm.4 . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
85,
92
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
146,
155
]
} |
thiocyanate and salicylate reduce the hexose-sensitive fraction of erythritol influx , but the hexose-insensitive erythritol permeability is not affected when chloride is replaced by the foreign anions . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
159,
167
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
195,
201
]
} |
[ arteriosclerosis obliterans of all four limbs . hypercholesteremia and hyperlipemia . ligation of the intestinal lymphatic trunk ] . | NA | {
"id": "C0020443",
"name": "hypercholesteremia",
"pos": [
50,
68
]
} | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
73,
85
]
} |
control of water content of non-metabolizing kidney slices by sodium chloride and polyethylene glycol ( peg 6000 ) . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
82,
101
]
} | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
104,
112
]
} |
cortical slices from kidneys of adult rats were equilibrated for 24 and 48 hr in the refrigerator in solutions containing 5 mm-k , 2.5 mm-ca and mg , m/15 phosphate buffer ( ph 7.4 ) , 5 mm cyanide and iodoacetate with 5 , 6 , 7 and 8 % polyethylene glycol ( peg 6000 ) and 77 , 154 , 308 , 462 and 770 mm-nacl.2 . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
237,
256
]
} | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
259,
267
]
} |
a study was made of the transfer of l-alanine , d-alanine and beta-alanine by sacs of everted small intestine of the rat.2 . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
38,
45
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
62,
74
]
} |
d-alanine and beta-alanine are transported against a concentration gradient and in this respect resemble l-alanine.3 . | NA | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
14,
26
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
107,
114
]
} |
l-methionine inhibited transfer of the three isomers in descending order , l-alanine , d-alanine and beta-alanine , while the magnitude of sarcosine inhibition was in the reverse order.7 . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
77,
84
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
101,
113
]
} |
at the concentration used ( 1 mm ) , l-alanine was transferred mostly by the methionine carrier , and beta-alanine mostly by the sarcosine carrier . | NA | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
37,
46
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
102,
114
]
} |
in contrast , prolonged operative stress resulted in a rise in the ovarian content of progesterone and 20-dihydroprogesterone whereas the adrenal progesterone content of these rats was lower than that of unstressed rats.4 . | NA | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
106,
125
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
146,
158
]
} |
the chronotropic and inotropic responses of the denervated dog heart to intravenous infusions of noradrenaline , adrenaline and isoprenaline were studied.2 . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
97,
110
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
113,
123
]
} |
the order of potency of the catecholamines in producing both chronotropic and inotropic effects was isoprenaline > adrenaline > noradrenaline.4 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
115,
125
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
128,
141
]
} |
for the same increase in heart rate produced by an infusion of a catecholamine , noradrenaline caused a greater inotropic effect than adrenaline , which in turn caused a greater increase than isoprenaline.5 . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
65,
78
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
192,
204
]
} |
for the same increase in heart rate produced by an infusion of a catecholamine , noradrenaline caused a greater inotropic effect than adrenaline , which in turn caused a greater increase than isoprenaline.5 . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
81,
94
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
134,
144
]
} |
adenylate cyclase of homogenates or lysates of mouse and rat lymphoid tissues was activated by the addition of fluoride ion , epinephrine , or norepinephrine , but not by any of several other hormones . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
143,
157
]
} |
when intact mouse thymocytes were first incubated in a culture medium at 37 degrees c with epinephrine or norepinephrine , a second addition of catecholamine after cell lysis no longer stimulated the enzymes . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
91,
102
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
106,
120
]
} |
this conformational assignment of oxytocin is consistent with hydrogen-deuterium exchange studies , with plots of temperature dependence of peptide proton chemical shifts , and with the coupling constants for the nh-ch dihedral angles . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
62,
70
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
71,
80
]
} |
mitotic inhibitors ( colcemid , colchicine , and vinblastine ) initiate dna synthesis in dense stationary cultures of mouse embryo fibroblast-like cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
131,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
147,
152
]
} |
a method has been developed to produce and purify gram quantities of t-2 toxin [ 4beta , 15-diacetoxy-8alpha- ( 3-methylbutyryloxy ) -12 , 13-epoxytrichothec-9-en-3alpha-ol ] , a mycotoxin elaborated by a strain of fusarium tricinctum isolated from toxic corn . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
73,
78
]
} | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
179,
188
]
} |
a phosphocreatine gradient opposite to that of glycogen in the organ of corti and the effect of salicylate on adenosine triphosphate and p-creatine in cochlear structures . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
2,
17
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
139,
147
]
} |
administration of a small dose of pentagastrin , a synthetic pentapeptide containing the biologically active portion of the native hormone gastrin , results in a marked , rapid , transitory increase in thyrocalcitonin secretion in the pig . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
34,
46
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
139,
146
]
} |
the weak antagonist pentazocine caused a significantly increased defaecation , but no significant change in body weight , while the opiates pethidine , codeine and methadone had no significant effect on body weight or defaecation.6 . | NA | {
"id": "C0005911",
"name": "change in",
"pos": [
98,
107
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
203,
214
]
} |
in contrast , no reactivity of two-cell or unfertilized egg embryos of four inbred strains was observed when antisera containing only multispecific h-2 cytolytic antibody were used . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
109,
117
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
162,
170
]
} |
[ increase in organizer cistrons for 5s rna and transfer rna in small xenopus laevis oocytes ] . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
40,
43
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
48,
60
]
} |
urinary excretion of testosterone and epitestosterone and plasma levels of lh and testosterone in the japanese and ainu . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
38,
53
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
82,
94
]
} |
[ value of an oral hypoglycemic medication combining a sulfonamide with a biguanide diabiphage ( chlorpropamide , metformin ) ] . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
74,
83
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
114,
123
]
} |
the prostaglandins also increased short-circuit current ( scc ) in isolated guinea pig ileal mucosa , with pge ( 1 ) and pge ( 2 ) again giving the greatest effects . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
4,
18
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
121,
124
]
} |
sera from mice immunized with synthetic rna reacted poorly with viral rna , whereas sera from mice immunized with viral rna reacted with all four ds rnas and resembled the lupus sera . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
40,
43
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
114,
123
]
} |
cholesterol and protein in 1.006 < d < 1.21 lipoprotein decreased in a reciprocal fashion , suggesting that these components might have been utilized in vldl production . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
44,
55
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
153,
157
]
} |
hemodynamic effects of adrenaline , noradrenaline and isopropylnoradrenaline in patients with a fixed rate artificial pacemaker . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
23,
33
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
63,
76
]
} |
evidence for the utilization of preformed purines by rat lymphoid tissues : implication to immunosuppression by 6-thiopurine analogues . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
42,
49
]
} | {
"id": "C0000618",
"name": "analogues",
"pos": [
125,
134
]
} |
after electrophoresis the different lipoprotein bands could conveniently be cut out and the lipid phosphorus determined . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
36,
47
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
92,
97
]
} |
the presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel , but the data suggest that the upper intestine is the major site of sterol uptake . | NA | {
"id": "C0031866",
"name": "plant sterol",
"pos": [
16,
28
]
} | {
"id": "C0038323",
"name": "sterols",
"pos": [
88,
95
]
} |
active lipogenesis was observed with short-chain fatty acids , glucose , pyruvate , lactate , and with the amino acids , alanine , leucine , and isoleucine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
107,
118
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
121,
128
]
} |
material with the same mobility on tlc as 7-dehydrocholesterol had less radioactivity than cholesterol , but more than sterols with the mobility of desmosterol . | NA | {
"id": "C0011181",
"name": "dehydrocholesterol",
"pos": [
44,
62
]
} | {
"id": "C0011704",
"name": "desmosterol",
"pos": [
148,
159
]
} |
[ effect of ascorbic acid , glutathione and some amino acids on adrenaline and noradrenaline-induced motor reactions of rabbit 's small intestine ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
79,
92
]
} |
n ( 6 ) -methylation of adenosine and 2-chloroadenosine reduced their coronary dilator activities , but had no effect on the duration of the response.6 . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
24,
33
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
38,
55
]
} |
after administration of digitoxin conjugation products as well as digoxigenin-bis-and digoxigenin-mono-digitoxosides were present in each of the compartments investigated , but the digitoxosides of digitoxigenin were intermediates in concentrations too low to be determined indicating a very high rate of conjugation and/or c-12 hydroxylation as compared with the cleavage of the digitoxoses.6 . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
24,
33
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
198,
211
]
} |
the use of spiral strips of rat aorta superfused with krebs solution is described for the assay of noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
99,
112
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
117,
127
]
} |
eleven patients with mild unconjugated hyperbilirubinaemia ( gilbert 's syndrome ) took part in a double-blind cross-over trial of phenobarbitone and phetharbital , a non-hypnotic barbiturate . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
131,
145
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
180,
191
]
} |
no ( 3 ) and i cause a small increase of the permeability and large anions such as benzenesulphonate , propionate or pyroglutamate cause a pronounced decrease of this permeability . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
13,
14
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
68,
74
]
} |
the effect on drinking of peptide precursors and of shorter chain peptide fragments of angiotensin ii injected into the rat 's diencephalon . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
26,
33
]
} | {
"id": "C0030935",
"name": "peptide",
"pos": [
66,
73
]
} |
it is concluded that the requirements for the dipsogenic activity of angiotensin are the same as those for its other biological actions with the qualification that the precursor peptides are also active , presumably because they give rise to angiotensin ii locally . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
69,
80
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
242,
256
]
} |
[ diagnosis of urinary tract infection . experiences from general practice of a dip-slide method ( inculator ) for the detection of bacteriuria ] . | NA | {
"id": "C0042029",
"name": "of urinary tract infection",
"pos": [
12,
38
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
132,
143
]
} |
5-hydroxytryptamine ( 5-ht ) , tryptamine , 5-methyltryptamine , 5-methoxytryptamine , n-methyltryptamine , 5-hydroxy-n , n-dimethyltryptamine , and histamine markedly protect mice subjected to burn , tourniquet and endotoxin shock . | NA | {
"id": "C0036751",
"name": "5-ht",
"pos": [
22,
26
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
65,
84
]
} |
5-hydroxytryptamine ( 5-ht ) , tryptamine , 5-methyltryptamine , 5-methoxytryptamine , n-methyltryptamine , 5-hydroxy-n , n-dimethyltryptamine , and histamine markedly protect mice subjected to burn , tourniquet and endotoxin shock . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
9,
19
]
} | {
"id": "C0027183",
"name": "dimethyltryptamine",
"pos": [
124,
142
]
} |
cocaine augmented the constriction responses to tyramine or noradrenaline but not those to adrenaline , acetylcholine or 5-hydroxytryptamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
60,
73
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
91,
101
]
} |
after ( 3 ) h-dopa , formation of noradrenaline was greatly reduced while formation of labelled dopamine was only moderately reduced suggesting that decarboxylation of dopa can occur in other than catecholamine containing neurones.6 . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
14,
18
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
197,
210
]
} |
this tumour basic protein ( obtained from several different neoplasms ) acts as an antigen in the cytopherometric test for malignant neoplasia and in general gives higher results than does brain basic protein . | NA | {
"id": "C0027642",
"name": "tumour",
"pos": [
5,
11
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
201,
208
]
} |
chloride distribution was measured between red cells and isotonic solutions with a range of concentrations of chloride and non-penetrating anions ( edta , citrate , gluconate ) . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
0,
8
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
139,
145
]
} |
correlation between h+ and anion movement in mitochondria and the key role of the phosphate carrier . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
27,
32
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
82,
91
]
} |
potentially immunocompetent cells of ( c57bl/6 x dba/2 ) f ( 1 ) mouse bone marrow are committed to antigenic determinants of sheep or burro erythrocytes prior to interaction with thymus-derived cells and participation in immune responses to administered antigens . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
100,
122
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
255,
263
]
} |
at this stage of differentiation marrow cells of this particular mouse strain are not yet restricted for the immunoglobulin m or immunoglobulin g antibody class . | NA | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
109,
125
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
129,
143
]
} |
glycoprotein nature of mitochondrial structural protein and neutral sugar content of mitochondrial proteins and structural proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0949610",
"name": "mitochondrial proteins",
"pos": [
85,
107
]
} |
[ roentgeno-spirometry of the lungs as a method of measuring the volume of residual air in the lungs of patients with silicosis and anthracosilicosis ] . | NA | {
"id": "C0037116",
"name": "silicosis",
"pos": [
118,
127
]
} | {
"id": "C0003164",
"name": "anthracosilicosis",
"pos": [
132,
149
]
} |
stereochemistry of pyrimidine nucleosides : conformational analysis of cytidine , thymidine , 4-thiouridine and deoxycytidine by the neglect of differential overlap molecular orbital method . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
19,
41
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
117,
125
]
} |
stereochemistry of pyrimidine nucleosides : conformational analysis of cytidine , thymidine , 4-thiouridine and deoxycytidine by the neglect of differential overlap molecular orbital method . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
71,
79
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
112,
125
]
} |
[ studies in ovulation-induction using human menopausal gonadotropin and animal pituitary gonadotropin together with human chorionic gonadotropin ] . | NA | {
"id": "C0025326",
"name": "human menopausal gonadotropin",
"pos": [
39,
68
]
} | {
"id": "C0018066",
"name": "pituitary gonadotropin",
"pos": [
80,
102
]
} |
on administration of sequences of four to eighteen i.v . injections of adrenaline or noradrenaline ( 200 mug ) , sheep responded to the first 4-5 injections with decreasing amounts of sweat discharge . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
71,
81
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
85,
98
]
} |
investigation of periodontosis with periodontitis : ultramicroanalysis of gingival fluid , gross examination of the periodontal ligament and approach to treatment . | NA | {
"id": "C0031106",
"name": "periodontosis",
"pos": [
17,
30
]
} | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
36,
49
]
} |
at a concentration of the drug that rapidly inhibits protein synthesis in blastulae by 95 % , uridine incorporation into rna continues for more than 1 hr and presumptive histone messenger rna is synthesized and transported into the cytoplasm where it is apparently associated with polyribosomes . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
121,
124
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
178,
191
]
} |
influence of urea , biuret and starch on amino acid patterns in ruminal bacteria and blood plasma and on nitrogen balance of steers fed high fiber purified diets . | NA | {
"id": "C0041942",
"name": "urea",
"pos": [
13,
17
]
} | {
"id": "C0005667",
"name": "biuret",
"pos": [
20,
26
]
} |
[ some enzymes and isoenzymes in mammalian cells infected with teschen disease virus and pseudorabies virus ] . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
7,
14
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
19,
29
]
} |
behaviour of some enzymes and isoenzymes in plasma liver and bile of rats treated with carbon tetrachloride . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
18,
25
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
30,
40
]
} |
the following 26 substances were quantitated after addition to postmortem blood speciments at concentrations of 1-10 microgram/ml : tilidine , diphenhydramine , dibenzepine , imipramine , chlorpromazine , amphetamine , pentazocine , phenacetin , methaqualone , meprobamate , parathion , diazepam , digoxin , beta-methyldigoxin , carbromal , glutethimide , amobarbital , pentobarbital , cyclobarbital , phenobarbital , diphenylhydantoin , carbutamide , tolbutamide , glycodiazin , tolazamide and chlorpropamide . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
298,
305
]
} | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
308,
326
]
} |
for the most part haemorrhage into the peritoneal cavity frequently occurred within the first 24 hours , whereas the intragastric bleeding appeared later . | NA | {
"id": "C0019065",
"name": "haemorrhage into",
"pos": [
18,
34
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
130,
138
]
} |
while haemorrhage into the peritoneal cavity had to be treated mostly by secondary laparotomy after adequate shock therapy , intragastric haemorrhage could be cured most without surgical treatment . | NA | {
"id": "C0019065",
"name": "haemorrhage into",
"pos": [
6,
22
]
} | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
138,
149
]
} |
the behaviour of the c-reactive protein -- an acute phase reactant=-in sera from pregnant women and women with different applications of hormonal contraceptives was analysed . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
21,
39
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
46,
66
]
} |
the dynamics of estradiol , estrone , 17 alpha-hydroxyprogesterone , progesterone and 20 alpha-dihydroprogesterone were investigated in the blood plasma of the pavian ( papio , hamadryas ) with regard to the menstrual cycle and in comparison with the human . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
54,
66
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
86,
114
]
} |
in histochemical ( with the glyoxylic acid ) and biochemical ( spectrofluorimetric trioxyindolic method ) investigations sources and content of catecholamines ( dopa , noradrenalin , adrenalin ) in the blood vessels , sympathetic chains , adrenals and cardiac ventricles have been studied in autumn-winter and spring-summer frogs at various temperatures . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
144,
158
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
161,
165
]
} |
in histochemical ( with the glyoxylic acid ) and biochemical ( spectrofluorimetric trioxyindolic method ) investigations sources and content of catecholamines ( dopa , noradrenalin , adrenalin ) in the blood vessels , sympathetic chains , adrenals and cardiac ventricles have been studied in autumn-winter and spring-summer frogs at various temperatures . | NA | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
168,
180
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
183,
192
]
} |
the paper deals with a description of the clinical picture and diagnosis of the main types of myodystrophies taking into account formes of muscular damages and a trend of generalization of a pathological process at the early phase of the disease . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
191,
211
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
238,
245
]
} |
along with this in prevalent torsion spastic hyperkinesis in the clinical picture there was a tendency towards an increase of dopamine excretion ( in the absence of dopa and noradrenalin changes ) , and a decreased adrenalin excretion . | NA | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
174,
186
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
215,
224
]
} |
risk for appearance of epilepsy and children 's convulsions among the sibs of the probands with parental allergic loading occurred to be 2 times higher than without it . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
23,
31
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
48,
59
]
} |
it is established that parental allergic loading and its degree is one of a family-constitutional risk factors that significantly raises the frequency of a phenotypical manifestation of hereditary predisposition to epilepsy and children 's convulsions . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
215,
223
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
240,
251
]
} |
it was demonstrated that noradrenaline , adrenaline , dopamine and isoproterenol as well as normethanephrine administered into the lateral ventricle of the rat brain , under urethane anaesthesia , caused significant changes in arterial blood pressure . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
41,
51
]
} |
basic amino acids ( arg , lys , his ) stimulate the absorption of serine and threonine from the caecum of pigs . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
0,
17
]
} | {
"id": "C0024337",
"name": "lys",
"pos": [
26,
29
]
} |
before beta-blockade , however , noradrenaline was the more potent vasoconstrictor in the gracilis muscle whereas adrenaline was more potent in adipose tissue . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
33,
46
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
114,
124
]
} |
intravenous infusion of adrenaline in doses causing vasodilatation in the muscle caused vasoconstriction in adipose tissue whereas intravenous infusion of noradrenaline caused vasoconstriction in both tissues . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
24,
34
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
155,
168
]
} |
an unusual space and time clustering of creutzfeldt-jakob disease and of other organic presenile dementia cases . | NA | {
"id": "C0022336",
"name": "creutzfeldt-jakob disease",
"pos": [
40,
65
]
} | {
"id": "C0497327",
"name": "organic presenile dementia",
"pos": [
79,
105
]
} |
a peculiar grouping of creutzfeldt-jacob disease ( cjd ) and of other organic presenile dementia ( opd ) cases in a small , prevalently rural area in czechoslovakia to the east of 19 degrees 35 ' e and to the north of 48 degrees 15 ' n was studied . | NA | {
"id": "C0022336",
"name": "creutzfeldt-jacob disease",
"pos": [
23,
48
]
} | {
"id": "C0497327",
"name": "organic",
"pos": [
70,
77
]
} |
in addition , seven cases of opd were detected in the same area , two of them being suspected as possible cjd according to clinical evidence . | NA | {
"id": "C0497327",
"name": "opd",
"pos": [
29,
32
]
} | {
"id": "C0022336",
"name": "cjd",
"pos": [
106,
109
]
} |
out of 49 mutants studied , 27 had a dna+ phenotype , 19 a dna+/-and 3 a dna- phenotype . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
35,
40
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
73,
76
]
} |
this apparent lack of adrenocortical responsiveness was accentuated by the concomitant finding of greatly hypertrophied , hemorrhagic , and lipid-depleted adrenal glands in the old rats vs a dynamic increase in circulating corticosterone levels and alterations in the weight of adrenal and thymus glands of the young rats . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
87,
94
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
268,
274
]
} |
cloxacillin should be included in the growing list of drugs capable of producing leukopenia and agranulocytosis . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
81,
91
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
96,
111
]
} |
we suggest that immobilization hypercalcemia occurs frequently in both children and adolescents after a single limb fracture of one weight-bearing bone , exercises in bed fail to prevent immobilization hypercalcemia , serial measurements of the serum ionized calcium and the urinary calcium/creatinine ratio are critical measures in treating such patients , and though complete mobilization is curative , transient calcitonin therapy is highly effective in reversing the disorders in calcium metabolism . | NA | {
"id": "C0020437",
"name": "hypercalcemia",
"pos": [
31,
44
]
} | {
"id": "C0006705",
"name": "disorders",
"pos": [
471,
480
]
} |
cultured skin fibroblasts from five affected patients showed a virtual absence of ornithine ketoacid transaminase ( okt ) ( l-ornithine:2-oxoacid aminotransferase e.c.2.6.1.13 ) activity . | NA | {
"id": "C0029278",
"name": "ornithine ketoacid transaminase",
"pos": [
82,
113
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
146,
162
]
} |
studies using central nervous system ( cns ) stimulants ( amphetamines and methylphenidate , deanol , pemoline , caffeine ) , antidepressants ( imipramine and desipramine ) , anticonvulsants ( phenytoin and primidone ) , antianxiety agents ( chlordiazepoxide , hydroxyzine , meprobamate ) , antipsychotic agents ( phenothiazines , thioxanthenes , butyrophenones ) and miscellaneous agents ( benztropine , thyrotropin-releasing hormone , megavitamins ) are discussed . | NA | {
"id": "C0002763",
"name": "central nervous system",
"pos": [
14,
36
]
} | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
58,
70
]
} |
autopsy examination of a patient with well-documented supravalvular aortic stenosis and other characteristic features of the idiopathic infantile hypercalcemia syndrome revealed previously unreported hyperplasia of parafollicular cells ( c cells ) . | NA | {
"id": "C0003499",
"name": "supravalvular aortic",
"pos": [
54,
74
]
} | {
"id": "C0175702",
"name": "idiopathic infantile",
"pos": [
125,
145
]
} |
the increase in risk for heavier drinkers appears to be due to beer consumption , in spite of the lower average amount of ethanol consumed by beer drinkers as compared to wine drinkers . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
63,
67
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
122,
129
]
} |
the increase in risk for heavier drinkers appears to be due to beer consumption , in spite of the lower average amount of ethanol consumed by beer drinkers as compared to wine drinkers . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
122,
129
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
171,
175
]
} |
o1 , o2 , and o3 regularly appear in the ascending branch of the b-wave complex , and after pre-dark adaptation the less differentiated o4 and o5 appear as well , exhibiting variable potental heights and durations as the dark time progresses . | NA | {
"id": "C0030054",
"name": "o2",
"pos": [
5,
7
]
} | {
"id": "C0030106",
"name": "o3",
"pos": [
14,
16
]
} |
the action of dopamine was evaluated in 18 patients with cardiogenic shock after myocardial infarction , in 14 patients with heart failure and in 18 patients with low-output syndrome after cardiac surgery . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
57,
74
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
81,
102
]
} |
the incidence of a positive family history is higher than found in other epileptic groups , suggesting that sleep seizures are genetically determined . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
73,
82
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
114,
122
]
} |
on the occurrence of fibres of calcium sulphate resembling amphibole asbestos in samples taken for the evaluation of airborne asbestos . | NA | {
"id": "C0206121",
"name": "amphibole asbestos",
"pos": [
59,
77
]
} | {
"id": "C0003947",
"name": "asbestos",
"pos": [
126,
134
]
} |
a double-blind comparative study of the use of garamycine ( gentamicin ) ear drops and tsp ( trimethroprim-sulphacetamide-polomyxin b ) ear drops in the treatment of 100 cases of otorrhoea due to external otitis , a recurrent otitis media accompanied by perforation of the drum , an infection of the mastoid cavity or a postoperative infection , provided evidence of the effectiveness of both medications . | NA | {
"id": "C1154187",
"name": "ear drops",
"pos": [
73,
82
]
} | {
"id": "C0991568",
"name": "drops",
"pos": [
140,
145
]
} |
of the five patients who were relieved of bppv by posterior ampullary nerve transection prior to 1974 , the long-term follow-up on four revealed continued relief of vertigo . | NA | {
"id": "C0155502",
"name": "bppv",
"pos": [
42,
46
]
} | {
"id": "C0042571",
"name": "vertigo",
"pos": [
165,
172
]
} |
persistence of the vertigo in these two patients strengthens the conclusion that the posterior semicircular canal sense organ is largely responsible for bppv . | NA | {
"id": "C0042571",
"name": "vertigo",
"pos": [
19,
26
]
} | {
"id": "C0155502",
"name": "bppv",
"pos": [
153,
157
]
} |
this includes the prothrombin time , the activated partial thromboplastin time , the serial thrombin time , the heat precipitation fibrinogen level , the platelet count , red cell morphology , the levels of fibrin ( fibrinogen ) degradation products and selected factor assays . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
131,
137
]
} | {
"id": "C0163275",
"name": "fibrinogen",
"pos": [
216,
226
]
} |
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