text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in both patient groups significant increases in epinephrine and norepinephrine occurred befored cardiopulmonary bypass , with accompanying increase of blood pressure in the valve replacement patients . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
48,
59
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
64,
78
]
} |
after cardiopulmonary bypass , aorta-coronary bypass patients had epinephrine , norepinephrine and blood pressure equal to levels before cardiopulmonary bypass . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
66,
77
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
80,
94
]
} |
exposure of cultured human fibroblasts to hyperthermia delayed the host-cell reactivation of uv-irradiated human adenovirus type 12 ( ad12 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
63,
66
]
} |
for example , no benzodiazepine has been shown to be superior to chlordiazepoxide in the treatment of acute anxiety , chronic anxiety neurosis or insomnia . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
17,
31
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
65,
81
]
} |
persons more than 70 years old should receive initial doses of benzodiazepines 50 % less than those prescribed for younger persons , and individuals with cirrhosis should receive chlordiazepoxide or diazepam in one third the usual dose ; | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
63,
78
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
179,
195
]
} |
aminoglycoside concentrations after intravenous administration of the drugs were within the expected range ( gentamicin and tobramycin 4 to 6 microgram/ml and amikacin 15 to 20 microgram/ml ) . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
0,
14
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
109,
119
]
} |
the presumed mechanism of increased survival is an inhibition of fibrin deposition around circulating tumor cells , thereby preventing their adherence to capillary endothelium to initiate metastasis formation . | NA | {
"id": "C0027625",
"name": "circulating",
"pos": [
90,
101
]
} | {
"id": "C0027627",
"name": "metastasis",
"pos": [
188,
198
]
} |
tra cells showed no increase in steroidogenic differentiation in response to those culture environment factors that normally cause modulation of the fibroblast-shaped adrenocortical stem cells to more differentiated steroid-secreting cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
149,
159
]
} |
an alternative hypothesis , consistent with these results , is that dna is the principal binding substrate for intranuclear acridine orange and that the dna of certain tumor cells is more accessible to acridine orange than is the dna of normal cells . | NA | {
"id": "C0012930",
"name": "dna",
"pos": [
68,
71
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
230,
233
]
} |
histopathologically , the induced tumors bear a close resemblance to human colon adenocarcinoma , and the development of pulmonary metastases in one of the animals with multiple primary tumors demonstrated their malignancy . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
34,
40
]
} | {
"id": "C0027663",
"name": "multiple primary tumors",
"pos": [
169,
192
]
} |
deoxyadenosine but not adenosine reversed the antiviral activity of 9-beta-d-arabinofuranosyladenine ( ara-a ) and 9-beta-d-arabinofuranosylhypoxanthine ( ara-h ) when used in the presence of coformycin , an inhibitor of adenosine deaminase . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
5,
14
]
} | {
"id": "C0042646",
"name": "ara-a",
"pos": [
103,
108
]
} |
all of the implantation tumors were of mesenchymal type , comprising variously a range of cell forms including fibroblast-like spindle cells , smooth muscle fibers , and `` '' giant '' '' cells , which resembled common aspects of the parent mesenchymal tumors induced in the rat kidney by dmn . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
90,
94
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
111,
121
]
} |
twenty-one of the 42 patients had received prior therapy with cyclophosphamide and 12 of these patients ( two with leukemia and ten with lymphoma ) responded , thus suggesting that as in the treatment of l1210 leukemia , isophosphamide is effective for tumors resistant to prior cyclophosphamide therapy . | NA | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
221,
235
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
279,
295
]
} |
marrow suppression was reflected in peripheral erythropenia , thrombocytopenia , and leukopenia and also in medullary erythropenia and granulocytopenia . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
85,
95
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
135,
151
]
} |
phase ii clinical trial with vindesine for remission induction in acute leukemia , blastic crisis of chronic myeloid leukemia , lymphosarcoma , and hodgkin 's disease : absence of cross-resistance with vincristine . | NA | {
"id": "C0024299",
"name": "lymphosarcoma",
"pos": [
128,
141
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
148,
166
]
} |
a high proportion of remissions were obtained in acute lymphoid leukemia and blastic crisis of chronic myeloid leukemia , and a few responses have been registered in lymphosarcoma and hodgkin 's disease . | NA | {
"id": "C0024299",
"name": "lymphosarcoma",
"pos": [
166,
179
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
184,
202
]
} |
contractile proteins synthesized by muscle cultures were identified by their co-electrophoresis on two-dimensional gels with contracile proteins purified from quail breast muscle . | NA | {
"id": "C0009915",
"name": "contractile",
"pos": [
0,
11
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
136,
144
]
} |
the balbiani ring 75s rna has properties of a messenger rna coding for secretory proteins . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
22,
25
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
46,
59
]
} |
using this assay we have investigated the effects of three proteases , subtilisin pbn ' , subtilisin carlsberg and alpha-chymotrypsin . | NA | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
71,
81
]
} | {
"id": "C0038597",
"name": "subtilisin carlsberg",
"pos": [
90,
110
]
} |
this ni band was missing or scarce in the parotid saliva and had an amino acid composition rich in glycine , lysine , serine , glutamic acid , aspartic acid , and histidine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
68,
78
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
99,
106
]
} |
it displays an antitumoral activity in mice with a better chemotherapeutic index than daunorubicin and doxorubicin . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
86,
98
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
103,
114
]
} |
it is shown with the electron microscope that the 28 s rna component of the ribosomal rna extracted from chicken fibroblasts contains secondary structures which are not present in the 18s component . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
55,
58
]
} | {
"id": "C0035701",
"name": "rna",
"pos": [
86,
89
]
} |
these challenges are in addition to the expected difficulties of helping young children to adjust to a new situation and the presence of unfamiliar adults and children . | NA | {
"id": "C0728836",
"name": "of",
"pos": [
62,
64
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
159,
167
]
} |
the x-linked enzyme , glucose-6-phosphate dehydrogenase ( g-6-pd ) was used as a cellular marker to study the clonal characteristics of human atherosclerotic lesions from females heterozygous for g-6-pd isoenzymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
13,
19
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
203,
213
]
} |
the method ( method i ) now in use by the lipid research clinics , in which mn2+ is at 46 mmol/liter final concentration , is reasonably accurate , but precipitation and sedimentation of lipoproteins other than high-density lipoproteins is often incomplete . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
42,
47
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
224,
236
]
} |
the enzymes from these two sources are very similar with respect to initial velocity kinetic constants , ph optima of the transpeptidation and autotransfer reactions , heat stability , competitive inhibition by glutathione of the colorimetric assay in which gamma-glutamyl-4-nitroanilide is substrate , stability of catalytic activity to trypsinization , and relative rates of transfer of the gamma-glutamyl moiety from gamma-glutamyl-4-nitroanilide and l- [ glycine-2-3/ ] glutathione to some amino acids and small peptides . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
459,
466
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
494,
505
]
} |
the fatty acid contents of thirteen commercial preparations of human albumin were found to be in the range 0.03 to 9 mol of fatty acid/mol albumin . | NA | {
"id": "C0304925",
"name": "human albumin",
"pos": [
63,
76
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
139,
146
]
} |
the source and fatty acid content of commercial albumin preparations should be considered when comparing studies of the binding of drugs to human albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
48,
55
]
} | {
"id": "C0304925",
"name": "human",
"pos": [
140,
145
]
} |
haemoglobin a is separated from haemoglobin a2 by electrophoresis on cellogel in discontinuous buffer at alkaline ph . | NA | {
"id": "C0019016",
"name": "haemoglobin a",
"pos": [
0,
13
]
} | {
"id": "C0019019",
"name": "haemoglobin a2",
"pos": [
32,
46
]
} |
evidence is presented which supports the idea that these two syndromes are not phenotypic variants of the same autosomal dominant mutation but distinct disease entities . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
61,
70
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
152,
159
]
} |
haptenic antibody , which was found in antisera taken 20 days after secondary immunization , was assessed for cross-reaction with a series of n-acylated ox insulins . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
9,
17
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
39,
47
]
} |
electron microscopic study of 9 osteosarcomas corroborates the light microscopic observation that cells with osteoblastic , chondroblastic and fibroblastic features occur in osteosarcomas . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
98,
103
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
143,
155
]
} |
observing the fecal route to be the major source of elimination of radiolabel following intravenous injection of [ 3h ] -vcr in our patients previously , we now conclude the biliary system to be the principal route of excretion of vcr and its products . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
52,
63
]
} | {
"id": "C1373186",
"name": "route of",
"pos": [
209,
217
]
} |
plasma concentrations of codeine and morphine were determined by specific radioimmunoassays in healthy human subjects at various times following oral administration of analgesic preparations containing therapeutic doses of codeine phosphate . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
25,
32
]
} | {
"id": "C0009217",
"name": "codeine",
"pos": [
223,
230
]
} |
sar1-ala8-angiotensin ii ( an angiotensin antagonist ) was infused in rats during the development and maintenance of renal hypertension produced by aortic ligation between renal arteries . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
10,
24
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
30,
41
]
} |
we report a study of the comparison of antiepileptic drugs ( phenobarbital , phenytoin , primidone , and carbamazepine ) by the enzyme multiplied immunoassay technique `` '' emit '' '' and the gas chromatography ( glc ) method . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
61,
74
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
89,
98
]
} |
proteolytic enzymes in lymphoproliferative disorders , bile acids in obstructive hepatobiliary disease , parathyroid hormone in chronic renal failure , and prostaglandins and kinins are but a few of the chemicals that may ultimately be responsible for the development of pruritus in these and other purely cutaneous disorders . | NA | {
"id": "C0033774",
"name": "pruritus",
"pos": [
271,
279
]
} | {
"id": "C0037274",
"name": "cutaneous disorders",
"pos": [
306,
325
]
} |
mezlocillin ( baypen ) , carbenicillin and mezlocillin combined with gentamicin , sisomicin , tobramycin and amikacin , respectively , were tested in vitro against 325 fresh clinical isolates of pathogenic gram-negative bacteria using the tube dilution procedure . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
69,
79
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
82,
91
]
} |
the comparison of the effectiveness of the mezlocillin-aminoglycoside combinations demonstrates the superiority of mezlocillin-sisomicin against escherichia coli , klebsiella , serratia and proteus spp. , whereas mezlocillin-tobramycin is most active against gentamicin-sensitive pseudomonas aeruginosa , and mezlocillin-amikacin against enterobacter and gentamicin-resistant p. aeruginosa . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
55,
69
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
355,
365
]
} |
the comparison of the effectiveness of the mezlocillin-aminoglycoside combinations demonstrates the superiority of mezlocillin-sisomicin against escherichia coli , klebsiella , serratia and proteus spp. , whereas mezlocillin-tobramycin is most active against gentamicin-sensitive pseudomonas aeruginosa , and mezlocillin-amikacin against enterobacter and gentamicin-resistant p. aeruginosa . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
127,
136
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
355,
365
]
} |
mezlocillin-amikacin showed the lowest resistance rate ( 10.2 % ) followed by mezlocillin-sisomicin ( 12.3 % ) , mezlocillin-gentamicin ( 15.1 % ) and mezlocillin-tobramycin ( 18.5 % ) . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
90,
99
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
125,
135
]
} |
five nitrofurans- nitrofurantoin , nifuratel , nitrofurazone , furazolidone and and sq 18,506 -- have been tested against 201 microbial strains . | NA | {
"id": "C0028155",
"name": "nitrofurans",
"pos": [
5,
16
]
} | {
"id": "C0028070",
"name": "nifuratel",
"pos": [
35,
44
]
} |
five nitrofurans- nitrofurantoin , nifuratel , nitrofurazone , furazolidone and and sq 18,506 -- have been tested against 201 microbial strains . | NA | {
"id": "C0028155",
"name": "nitrofurans",
"pos": [
5,
16
]
} | {
"id": "C0028157",
"name": "nitrofurazone",
"pos": [
47,
60
]
} |
five nitrofurans- nitrofurantoin , nifuratel , nitrofurazone , furazolidone and and sq 18,506 -- have been tested against 201 microbial strains . | NA | {
"id": "C0028155",
"name": "nitrofurans",
"pos": [
5,
16
]
} | {
"id": "C0016855",
"name": "furazolidone",
"pos": [
63,
75
]
} |
the cl-free analogue , gamma- ( phenothiazinyl-10 ) -propylamine sulfone , was excreted by patients receiving perazine and by a volunteer after ingestion of the primary amine sulfoxide . | NA | {
"id": "C0033504",
"name": "propylamine",
"pos": [
53,
64
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
169,
174
]
} |
in incubations of cyclic imides ( ph 8 , 1 hr ) with a rat liver dihydropyrimidinase preparation from which omega-amidase had been removed , adipimide was classed as a good substrate and succinimide and glutarimide were classed as very poor but definite substrates . alpha-phenylsuccinimide , the n-demethylated metabolite of phensuximide , was a much better substrate than succinimide . alpha-phenylglutarimide was not a substrate . | NA | {
"id": "C0020926",
"name": "imides",
"pos": [
25,
31
]
} | {
"id": "C0038623",
"name": "succinimide",
"pos": [
374,
385
]
} |
the pharmacokinetics and steady-state myocardial uptake of the antiarrhythmic drug disopyramide ( dp ) were determined in dogs after oral or intravenous administration of [ 14c ] disopyramide phosphate . | NA | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
83,
95
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
179,
201
]
} |
changes in the incorporation of the label in the free amino-acids , in total cholesterol of liver and ribosomal protein as well as the proteins in the supernatant over ribosomes were examined . | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
102,
111
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
135,
143
]
} |
it is specific to follitropin as demonstrated by the very low binding activity of the follitropin alpha and beta subunits and of the other glycoprotein hormones . | NA | {
"id": "C0733758",
"name": "follitropin",
"pos": [
18,
29
]
} | {
"id": "C1268876",
"name": "follitropin alpha",
"pos": [
86,
103
]
} |
the gross synthesis of ribosomal dna was then determined over three consecutive mitotic divisions from the ratio of 3h to 14c in a hybrid formed between the extracted ribosomal [ 3h ] dna and a [ 14c ] rrna probe . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
23,
36
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
184,
187
]
} |
l-2-hydroxytetradecanoic acid was recognized as a characteristic , although minor , constituent of the lipid a component of salmonella lipopolysaccharides . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
103,
110
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
135,
154
]
} |
experiments with fractionated microtubule proteins indicate that tubulin-free microtubule associated proteins bind to dna , while tubulin free of microtubule-associated proteins does not . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
30,
50
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
130,
137
]
} |
experiments with fractionated microtubule proteins indicate that tubulin-free microtubule associated proteins bind to dna , while tubulin free of microtubule-associated proteins does not . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
30,
50
]
} | {
"id": "C0026045",
"name": "microtubule-associated proteins",
"pos": [
146,
177
]
} |
the effect of the aminoglycosides amikacin , gentamicin , netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
18,
33
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
45,
55
]
} |
the effect of the aminoglycosides amikacin , gentamicin , netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
45,
55
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
69,
78
]
} |
the effect of the aminoglycosides amikacin , gentamicin , netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
58,
68
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
69,
78
]
} |
fifteen adults were each given gentamicin , sisomicin or tobramycin 3 mg/kg bodyweight , 10 subjects received netilmicin 3 mg/kg or amikacin 15 mg/kg additionally seven subjects amikacin 10 mg and six subjects netilmicin 6 mg on three consecutive days . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
31,
41
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
44,
53
]
} |
fifteen adults were each given gentamicin , sisomicin or tobramycin 3 mg/kg bodyweight , 10 subjects received netilmicin 3 mg/kg or amikacin 15 mg/kg additionally seven subjects amikacin 10 mg and six subjects netilmicin 6 mg on three consecutive days . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
44,
53
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
210,
220
]
} |
there was no difference between gentamicin , netilmicin , and sisomicin , which had an effect intermediate between the other two compounds . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
32,
42
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
62,
71
]
} |
there was no difference between gentamicin , netilmicin , and sisomicin , which had an effect intermediate between the other two compounds . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
45,
55
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
62,
71
]
} |
differences in suiciding by various tritiated nucleosides were observed between two functional assays for in vitro lymphocytic precursor cell development , the hemolysin plaque-forming cell ( pfc ) assay and the b lymphocytic colony-forming cell ( cfc-l ) assay , using bdf1 mouse spleen cells . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
127,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
288,
293
]
} |
the results suggest that antipyrine oxidation was not influenced by temperature changes in the range of moderate fever and that temperature changes affected different types of metabolic reactions differently . | NA | {
"id": "C0015967",
"name": "fever",
"pos": [
113,
118
]
} | {
"id": "C0005904",
"name": "temperature changes",
"pos": [
128,
147
]
} |
the beta-adrenergic agonists isoproterenol , epinephrine and norepinephrine competed for binding with potencies paralleling their pharmacological potencies as beta-adrenergic effectors . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
45,
56
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} |
inhibition by d , l-methadone of rna and protein synthesis in neonatal mice : antagonism by naloxone or naltrexone . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
92,
100
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
104,
114
]
} |
a specific opioid effect is suggested by the finding that naltrexone or in part , naloxone , given concomitantly with with the methadone prevents development of the biochemical lesion . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
58,
68
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
82,
90
]
} |
norepinephrine failed to increase plasma cyclic amp when injected alone into fasted rats , in contrast with sharp increases elicited by isoproterenol , epinephrine or tyramine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
152,
163
]
} |
phentolamine was very effective in enhancing the epinephrine- , norepinephrine- or tyramine-induced increase in plasma cyclic amp but without effect on the isoproterenol-induced increase . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
49,
60
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
64,
78
]
} |
some biological properties of an `` '' irreversible '' '' antagonist of neurohypophyseal hormones , deamino- [ phe ( 4-brch2conh ) 2 ] -oxytocin , and its isosteric analogue , deamino- [ phe ( 4-ch3ch2conh ) 2 ] -oxytocin . | NA | {
"id": "C0032017",
"name": "f neurohypophyse",
"pos": [
70,
86
]
} | {
"id": "C0030095",
"name": "] -oxytoc",
"pos": [
210,
219
]
} |
the acute ipsilateral circling and the chronic contralateral turning , on the other hand , seem to be independent of the integrity of the dopaminergic system and may be due to an initial stimulation , followed by destruction , of a nigral neuronal system which mediates turning behavior in a manner opposite to that of nigro-striatal dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
138,
150
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
334,
342
]
} |
the inhibitory effect of morphine on the release of acetylcholine ( ach ) from the rat cerebral cortex was antagonized by theophylline , caffeine and 3-isobutyl-1-methylxanthine ( ibmx ) . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
122,
134
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
150,
177
]
} |
the opiate agonist potency of thirteen synthetic enkephalin pentapeptides has been examined on the electrically stimulated guinea pig ileum and mouse vas deferens preparations in comparison with methionine and leucine enkephalins , beta-endorphin and normorphine . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
49,
59
]
} | {
"id": "C0014294",
"name": "leucine enkephalins",
"pos": [
210,
229
]
} |
in the guinea-pig , chondroitin and dermatan-sulfates accounted for at least 50 % of the uronic acids , whereas , in the rat , heparan sulfates comprised 65 -- 70 % of them . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
20,
31
]
} | {
"id": "C0011602",
"name": "dermatan-sulfates",
"pos": [
36,
53
]
} |
t-2 toxin , a trichothecene metabolite of several fusarium spp . causes depigmentation of dark mouse hair at the site of its application . | NA | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
0,
9
]
} | {
"id": "C0040952",
"name": "trichothecene",
"pos": [
14,
27
]
} |
[ effect of tropaphene and fentolamin on the spasmogenic effects of adrenaline , noradrenaline , serotonin and other biologically active substances ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
68,
78
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
81,
94
]
} |
the effect of bovine pancreatic ribonuclease ( a rnase ) and bull seminal ribonuclease ( as rnase ) on human lymphocytes undergoing blastic transformation . | NA | {
"id": "C0035541",
"name": "pancreatic ribonuclease",
"pos": [
21,
44
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
92,
97
]
} |
when the mother was fed ad lib , birth weight of individual pups and later body weight were correlated regardless of litter size . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
33,
45
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
75,
86
]
} |
antibody to coxsackie b3 virus was labeled with fluorescein isothiocyanate , and antibody to insulin was labeled with rhodamine . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0021644",
"name": "antibody",
"pos": [
81,
89
]
} |
by use of a double-label antibody technique , three populations of cells were identified : uninfected insulin-containing beta cells , which stained only with rhodamine-labeled anti-insulin antibody ; | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
25,
33
]
} | {
"id": "C0021644",
"name": "anti-insulin antibody",
"pos": [
176,
197
]
} |
diabetes is known to produce increased levels of the branched chain amino acids in plasma , heart and muscle as well as increased oxidation of [ 14c ] -leucine by nerves and muscles from rats . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
53,
79
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
152,
159
]
} |
retinas from diabetic rats have been found to oxidize significantly more of the branched chain amino acids , leucine , isoleucine and valine than did control retinas when incubated in media containing 16.5 mmol/l glucose . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
80,
106
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
122,
129
]
} |
retinas from diabetic rats have been found to oxidize significantly more of the branched chain amino acids , leucine , isoleucine and valine than did control retinas when incubated in media containing 16.5 mmol/l glucose . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
80,
106
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
119,
129
]
} |
retinas from diabetic rats have been found to oxidize significantly more of the branched chain amino acids , leucine , isoleucine and valine than did control retinas when incubated in media containing 16.5 mmol/l glucose . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
80,
106
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
134,
140
]
} |
treatment of the perfusing medium with immobilised proteinases ( trypsin , chymotrypsin , protease ) did not alter the response except in the presence of putrescine . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
51,
62
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
90,
98
]
} |
deletions also occur within a psc101 plasmid containing a tandem duplication of a segment ( 4.7 kb ) including both psc101 dna and rdna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
123,
126
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
131,
135
]
} |
[ value of amoxicillin and ampicillin in the treatment of septic abortion ( double blind and random comparative studies ) ] . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
11,
22
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
27,
37
]
} |
the hypothesis that mictochondrial damage is a significant factor in the pathogenesis of alcoholic liver disease ( ald ) was investigated by enzymic analysis of mitochondrial fractions isolated from needle biopsy specimens from control patients , patients with fatty liver due to chronic alcoholism , and from patients with other forms of liver disease . | NA | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
261,
272
]
} | {
"id": "C0023895",
"name": "of liver disease",
"pos": [
336,
352
]
} |
good correlation was found between these objective indices of lower oesophageal disease and the presence of symptoms such as dysphagia and heartburn . | NA | {
"id": "C0014852",
"name": "oesophageal disease",
"pos": [
68,
87
]
} | {
"id": "C0011168",
"name": "dysphagia",
"pos": [
125,
134
]
} |
markedly reduced levels of prekallikrein and high molecular weight kininogen were seen at circulatory collapse and free kallikrein was detected . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
27,
40
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
120,
130
]
} |
the effect of the activating substances for transferring the hageman factor into its active form are represented with the role of the pre-kallikrein ( fletcher factor ) and of the highly molecular kininogen ( fitzgerald factor ) being referred to . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
138,
148
]
} | {
"id": "C0033024",
"name": "fletcher factor",
"pos": [
151,
166
]
} |
among the different types of hepatic porphyrias , acute intermittent porphyria ( aip ) and the group of chronic hepatic porphyrias ( chp ) are most frequently seen in europe . | NA | {
"id": "C0162533",
"name": "hepatic porphyrias",
"pos": [
29,
47
]
} | {
"id": "C0162565",
"name": "acute intermittent porphyria",
"pos": [
50,
78
]
} |
in about 27 per cent of cadavers dead from 6 to 12 hours the eyelids were open and thereafter they were closed gradually and all of them were closed from 36 hours to 4 days . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
24,
32
]
} | {
"id": "C0011065",
"name": "dead",
"pos": [
33,
37
]
} |
in death from exsanguination many were open and in death from drowning and carbon monoxide poisoning all were closed . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
3,
8
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
62,
70
]
} |
the cadavers with open eyelids are estimated to have been dead less than 36 hours or over 4 days . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
4,
12
]
} | {
"id": "C0011065",
"name": "dead",
"pos": [
58,
62
]
} |
the conclusions are as follows : 1 ) differences due to the states of the eyelids of cadavers , either open or closed , gave rise to slight variations of the turbidity of the cornea only within 12 hours after death . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
85,
93
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
209,
214
]
} |
in death from intracranial injuries and asphyxia the strong turbidity developed earlier than in the other types of death . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
3,
8
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
40,
48
]
} |
to test this hypothesis , we observed the effect of acth 4-10 on the passive avoidance of brattleboro rats with diabetes insipidus resulting from a total genetic deficiency of vasopressin ( di ) and brattleboro rats without diabetes insipidus ( he ) . | NA | {
"id": "C0687720",
"name": "deficiency",
"pos": [
162,
172
]
} | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
224,
242
]
} |
the ability of the treated cells to activate allogeneic cells in mlr depends upon the concentration of glutaraldehyde and the type of tissue culture medium utilized . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
45,
61
]
} |
thus mammalian serum ig ( rabbit gamma globulin ( rgg ) ) had a shorter t1/2 ( 6.3 days ) in snake than did homologous snake igg ( 38 days ) , whereas in mice , rgg had a longer t1/2 ( 3.8 days ) than snake ig ( 0.9 days ) . | NA | {
"id": "C0017007",
"name": "rgg",
"pos": [
50,
53
]
} | {
"id": "C0021027",
"name": "ig",
"pos": [
207,
209
]
} |
eliciting antigenicities of benzylpenicillin , ampicillin and carbenicillin preparations examined with the reagin-mediated passive cutaneous anaphylaxis system . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
28,
44
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
47,
57
]
} |
eliciting antigenicities of benzylpenicillin , ampicillin and carbenicillin preparations examined with the reagin-mediated passive cutaneous anaphylaxis system . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
28,
44
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
62,
75
]
} |
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