text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
digestion by pronase e destroyed only the cancer determinant and liberated two antigenic fragments corresponding to the nfa determinant and the nca determinant , respectively . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
79,
88
]
} | {
"id": "C0003316",
"name": "nfa determinant",
"pos": [
120,
135
]
} |
heavy metals in the spinal cord of normal rats and of animals treated with chelating agents : a quantitative ( zinc , copper , and lead ) and histochemical study . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
111,
115
]
} |
heavy metals in the spinal cord of normal rats and of animals treated with chelating agents : a quantitative ( zinc , copper , and lead ) and histochemical study . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
118,
124
]
} |
heavy metals in the spinal cord of normal rats and of animals treated with chelating agents : a quantitative ( zinc , copper , and lead ) and histochemical study . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
131,
135
]
} |
these components included ( 1 ) an acidic polysaccharide texture , ( 2 ) free aldehyde groups which arise during formalin fixation and ( 3 ) the oligosaccharide chains of rhodopsin . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
42,
56
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
145,
160
]
} |
of the amino acids added individually to the growth medium , only leucine and , to a lesser extent , methionine and alanine were effective , alpha-ketoisocaproate- and leucine-containing peptides repressed the activity , and leucine also repressed activity in adenyl cyclase-deficient and relaxed strains . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
7,
18
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
116,
123
]
} |
in bacterial agglutination and passive hemagglutination in some salmonella antisera , citrobacter 396 as well as its o-antigenic lipopolysaccharide expressed the serological factors 5 and 6 . | NA | {
"id": "C0069180",
"name": "o-antigenic",
"pos": [
117,
128
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
129,
147
]
} |
the heavy enzyme is a complex of one molecule of light enzyme ( consisting of three alpha subunits ) and approximately 60 beta subunits ( a. bacher , r. bauer , u. eggers , h. harders , and h. schnepple , p. 729 -- 732 , in t. p. singer ( ed . ) , flavins and flavoproteins , elsevier , amsterdam , 1976 ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
10,
16
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
22,
29
]
} |
nitrate did not inhibit reduction of ferric iron in heme-depleted membranes from the hem mutant unless hemin was added to restore l-lactate- and g3p-nitrate reductase activity . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
52,
56
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
103,
108
]
} |
this finding , that random dna sequences rather than specific ones were responsible for the majority of the dna-membrane interactions , argues against the folded chromosome 's being a static structure with specific dna sequences interacting with the cell envelope . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
27,
30
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
234,
235
]
} |
during synchronized growth , cell numbers increased rapidly in coordination with the period of rapid dna accumulation and exhibited a plateau during the period of reduced dna accumulation . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
101,
104
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
182,
183
]
} |
the mutations impaired the conversion of glutamic acid to glutamine and resulted in changes of both the activity and oligomeric structure of the enzyme glutamine synthetase . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
41,
49
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
152,
161
]
} |
the experimental data , including the dependence of the effect of replacement on the ion concentration , are consistent with the ideas that the tumbling frequency increases with depolarization of the bacterial membrane and that such anions as ms- and pr- are more able to permeate the membrane than is cl- . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
85,
88
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
233,
239
]
} |
little or no measurable activity was detected with isoamines , l-ornithine , l-lysine , and certain diamines or polyamines . | NA | {
"id": "C0011957",
"name": "diamines",
"pos": [
100,
108
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
112,
122
]
} |
pyridoxine , a co-factor in the decarboxylation of dopa , reverses the movement disorder of l-dopa intoxication . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
51,
55
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
92,
98
]
} |
sulfides or disulfides were oxidized to the corresponding sulfoxides or thiosulfinates , while thiosulfinate was oxidized to thiolsulfonate . | NA | {
"id": "C0038739",
"name": "sulfides",
"pos": [
0,
8
]
} | {
"id": "C0012771",
"name": "disulfides",
"pos": [
12,
22
]
} |
the differences in the binding of substrates such as sulfides and disulfides with the enzyme system are discussed in connection with differences in the spectra of the substrates in the reconstituted system with pure cytochrome p-450 . | NA | {
"id": "C0038739",
"name": "sulfides",
"pos": [
53,
61
]
} | {
"id": "C0012771",
"name": "disulfides",
"pos": [
66,
76
]
} |
chemical analysis of nuclear proteins and nucleic acids revealed that arginine/p molar ratio in herring sperm nuclei is unity but the ratio of arginine residues in protamine to phosphorus in the total dna is 0.86 . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
21,
37
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
164,
173
]
} |
chemical analysis of nuclear proteins and nucleic acids revealed that arginine/p molar ratio in herring sperm nuclei is unity but the ratio of arginine residues in protamine to phosphorus in the total dna is 0.86 . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
42,
55
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
201,
204
]
} |
three different types of chondroitin polysulfate-peptide , chondroitin sulfate d-peptide , chondroitin sulfate e-peptide , and chondroitin sulfate k-peptide , all contained xylose , galactose , and serine in a molar ratio of about 1 : 2 : 1 . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
25,
36
]
} | {
"id": "C0008466",
"name": "chondroitin sulfate",
"pos": [
127,
146
]
} |
consequently , it was proved that these chondroitin polysulfates are all linked to peptides by o-glycosidic bonds between xylose and serine , as in chondroitin sulfates a and c . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
40,
51
]
} | {
"id": "C0008466",
"name": "chondroitin sulfates",
"pos": [
148,
168
]
} |
precipitation with ammonium sulfate , acid treatment and ion exchange column chromatography using deae-cellulose , deae-sephadex a-50 , and cm-cellulose , successively . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
98,
112
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
143,
152
]
} |
by use of the viomycin-enzyme conjugate and the antiserum to viomycin , enzyme immunoassay of viomycin was successfully performed by the competitive binding procedure with the double-antibody method , and 0.1 to 4 ng of the antibiotic could be detected . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
48,
57
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
183,
191
]
} |
in the wild type parent of m31 , alpha-mannosidase-1 is modified by the addition of mannose and glucosamine ( probably as n-acetylglucosamine ) in the molar ratio of 5:2 . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
96,
107
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
122,
141
]
} |
alpha-mannosidase-1 was also found to contain phosphoserine/phosphothreonine residues . alpha-mannosidase-1 and other glycosidases are electrophoretically less negative when isolated from strain m31 than when isolated from wild type cells . | NA | {
"id": "C0024746",
"name": "mannosidase",
"pos": [
6,
17
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
118,
130
]
} |
the v156 nuclear rna is identical in sequence to the major virus-associated rna ( va rna1 or 5.5 s rna ) synthesized in intact cells ( ohe , k. , and weissman , s. m. ( 1971 ) j. biol . chem . 246 , 6991-7009 ) . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
9,
20
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
99,
102
]
} |
this process of systemic host defense has been shown to be depressed in patients following trauma , major surgery , burn injury , and during neoplastic disease , and , in part , mediated by a deficiency or depletion of the alpha2sb glycoprotein . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
91,
97
]
} | {
"id": "C0006434",
"name": "burn injury",
"pos": [
116,
127
]
} |
it is apparently the same enzyme ( pfk ii ) in all three strains , which shows that pfkb1 is a mutation affecting the amount of a normally minor isozyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
26,
32
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
145,
152
]
} |
the membranes bound immune gamma-globulins against subunit iv ( which faces the matrix side in intact mitochondria ) but failed to bind immune gamma-globulins against subunits ii + iii ( which face the outer side of the inner membrane in intact mitochondria ) . | NA | {
"id": "C0085297",
"name": "immune",
"pos": [
20,
26
]
} | {
"id": "C0021027",
"name": "immune",
"pos": [
136,
142
]
} |
the 5.8 s rna component together with 5 s rrna can be released from subunits or whole ribosomes by brief heat treatment or in 50 % formamide ; | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
10,
13
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
42,
46
]
} |
from amino acid analysis the peptide was found to be rich in basic amino acids and to have a molecular weight of 4621 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
5,
15
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
61,
78
]
} |
in contrast , pc ii has maximal activity with reoviral rna , some activity with rrna , and much less activity with the other substrates . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
55,
58
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
80,
84
]
} |
a single enzyme protein catalyzed the oxygenative ring cleavage of d- and l-tryptophan , d- and l-5-hydroxytryptophan , tryptamine , and serotonin . | NA | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
74,
86
]
} | {
"id": "C0000578",
"name": "l-5-hydroxytryptophan",
"pos": [
96,
117
]
} |
our observations and the detailed enzymatic data presented by maruta and korn ( ( 1977 ) j. biol . chem . 252 , 6501-6509 ) argue that the smaller acanthamoeba myosin-i ( pollard , t. d. , and korn , e. d. ( 1973 ) j. biol . chem , 248 , 4682-2690 ) does not arise by fragmentation of myosin-ii in the homogenate or extract . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
160,
166
]
} | {
"id": "C0027103",
"name": "myosin-ii",
"pos": [
285,
294
]
} |
a colony-stimulating factor ( m-csf ) has been partially purified and concentrated from mouse yolk sac-conditioned medium ( yscm ) . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
2,
27
]
} | {
"id": "C0079784",
"name": "m-csf",
"pos": [
30,
35
]
} |
this effect was virtually lost on removal of the fatty acids , and it was completely restored by recombination of the fatty acid-free albumin with the isolated and purified fatty acids . | NA | {
"id": "C0015688",
"name": "fatty acid-free",
"pos": [
118,
133
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
173,
184
]
} |
this conclusion was based on two observations : fatty acids in the absence of albumin were growth-inhibitory except in extremely dilute solutions , and beta-lactoglobulin , a protein possessing , like albumin , the ability to bind and release fatty acids , could replace albumin in the presence of fatty acids with similar growth-promoting effect . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
175,
182
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
271,
278
]
} |
however , the method of dna isolation was found to be of crucial importance when comparing satellite dna 's among different tissues . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
24,
27
]
} | {
"id": "C0012934",
"name": "satellite",
"pos": [
91,
100
]
} |
the product of the enzymatic reaction -- adenosine -- when added to the medium exhibited a toxic effect on these cells -- as did adenosine monophosphate . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
41,
50
]
} | {
"id": "C0001465",
"name": "adenosine monophosphate",
"pos": [
129,
152
]
} |
this inhibition of purine synthesis by guanine is reversible and its recovery is facilitated by adenine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
19,
25
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
96,
103
]
} |
rapid determination of amoxycillin ( clamoxyl ) and ampicillin ( penbritin ) in body fluids of many by means of high-performance liquid chromatography . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
23,
34
]
} | {
"id": "C0002680",
"name": "penbritin",
"pos": [
65,
74
]
} |
the application of thin-layer chromatography to the separation of 13 steroids , including androstanes , 4-androstenes and 5-androstenes , using silica gel and 1,2-propanediol-impregnated cellulose is described . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
69,
77
]
} | {
"id": "C0002854",
"name": "androstanes",
"pos": [
90,
101
]
} |
the application of thin-layer chromatography to the separation of 13 steroids , including androstanes , 4-androstenes and 5-androstenes , using silica gel and 1,2-propanediol-impregnated cellulose is described . | NA | {
"id": "C0002854",
"name": "androstanes",
"pos": [
90,
101
]
} | {
"id": "C0002862",
"name": "androstenes",
"pos": [
124,
135
]
} |
after group-wise separation of various c19 steroids on silica gel , the 3-hydroxy epimers of 5alpha-androstanes and 5-androstenes can be separated by thin-layer chromatography on impregnated cellulose plates . | NA | {
"id": "C0002854",
"name": "androstanes",
"pos": [
100,
111
]
} | {
"id": "C0002862",
"name": "androstenes",
"pos": [
118,
129
]
} |
use of an antigen consisting of purified isolated nuclei from a mixture of human cytomegalovirus-infected and uninfected fibroblasts in a 2:1 ratio is a simple and reliable method for eliminating nonspecific fluorescence associated with the presence of fc-immunoglobulin g receptors in the cytoplasm of infected cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
121,
132
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
312,
317
]
} |
other groups consisted of normal control animals , normal rats infused with sodium phosphate to raise filtered load of phosphate , subtotal nx rats parathyroidectomized ( ptx ) on the day of experiment , and normal ptx rats infused with sodium phosphate . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
83,
92
]
} | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
237,
253
]
} |
the fractional inhibition of cholesterol synthesis found after administration of an amount of cholesterol sufficient to raise the hepatic cholesterol ester content by 1 mg/g equalled only -- 0.36 when bile acid snythesis was increased by biliary diversion but was -- 0.92 when bile acid synthesis was suppressed by bile acid feeding . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
29,
40
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
138,
155
]
} |
human buccal and cervical-vaginal mucosal epithealial cells , fallopian tube mucosa , and sperm bound pili in greater numbers per micrometer2 of surface area ( 1 -- 10 ) than fetal tonsil fibroblasts , hela m cells , erythrocytes , or polymorphonuclear leukocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
54,
59
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
188,
199
]
} |
the administration of l-dopa suppresses prolactin ( prl ) secretion in normal subjects and in patients with hyperprolactinemia , although it is not known whether this effect , which requires the conversion of dopa to dopamine , is mediated peripherally or through the central nervous system . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
22,
28
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
217,
221
]
} |
urinary homovanillic acid excretion , which reflected peripheral dopa decarboxylation was similar in controls and tumor patients after l-dopa both alone and after carbidopa pretreatment . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
65,
69
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
135,
141
]
} |
catecholamines compete for the binding sites in a stereo-specific manner with the potency series of ( - ) epinephrine > ( - ) norepinephrine > ( +/- ) phenylephrine > ( - ) isoproterenol . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
0,
14
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
173,
186
]
} |
catecholamines compete for the binding sites in a stereo-specific manner with the potency series of ( - ) epinephrine > ( - ) norepinephrine > ( +/- ) phenylephrine > ( - ) isoproterenol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
106,
117
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
126,
140
]
} |
( - ) epinephrine was more potent than ( - ) norepinephrine in producing aggregation whereas ( - ) isoproterenol was ineffective . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
6,
17
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
45,
59
]
} |
( - ) epinephrine and ( - ) norepinephrine inhibited basal and prostaglandin e ( 1 ) -stimulated adenylate cyclase in a dose-related manner . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
6,
17
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
28,
42
]
} |
both interfered only with the activation of fibrin stabilizing factor ( coagulation factor xiii ) and , while totally preventing the conversion of this zymogen to the functional transamidating enzyme , fibrinoligase ( factor xiii ( a ) ) , they showed very little inhibition toward the enzyme itself . | NA | {
"id": "C0015528",
"name": "coagulation factor xiii",
"pos": [
72,
95
]
} | {
"id": "C0015533",
"name": "factor",
"pos": [
218,
224
]
} |
platelets from each of the five patients reacted normally with drug-dependent antibodies and with autoantibodies specific for platelets . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
78,
88
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
98,
112
]
} |
exogenous dibutyryl cyclic amp ( dbcamp ) reduced vft and increased vp by a concentration-related action whereas exogenous camp did not . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
10,
30
]
} | {
"id": "C0001455",
"name": "camp",
"pos": [
123,
127
]
} |
theophylline ( 1.0 mmol/liter ) increased the tissue content of camp by 58 % ( p < 0.001 ) and caused a leftward shift in the concentration-response curve to dbcamp . | NA | {
"id": "C0001455",
"name": "camp",
"pos": [
64,
68
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
158,
164
]
} |
an effect of camp on vft and vp could be shown in the presence of phosphodiesterase inhibition by theophylline . beta-1-adrenergic receptor blockade with atenolol did not alter the concentration-response curve for vft when dbcamp was administered . | NA | {
"id": "C0001455",
"name": "camp",
"pos": [
13,
17
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
223,
229
]
} |
in the presence of a nonstimulatory concentration of glucose ( 3.3 mm ) , both sulfonylureas caused a rapid increase in islet [ ( 3 ) h ] cyclic amp , which declined within 5 ( tolbutamide ) or 10 min ( glibenclamide ) . | NA | {
"id": "C0038766",
"name": "sulfonylureas",
"pos": [
79,
92
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
203,
216
]
} |
the [ ( 3 ) h ] cyclic amp response to glibenclamide was influenced by prior exposure of the islets to glucose , a 30-min preincubation with 27.7 mm glucose , enhancing the response to the sulfonylurea over a subsequent 5-min stimulation period . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
39,
52
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
189,
201
]
} |
nevertheless , it seems unlikely that net secretion of bicarbonate by collecting tubules involves specific exchange for chloride , as has been proposed for turtle bladders , because replacement of chloride by other anions did not inhibit bicarbonate secretion by collecting tubules . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
120,
128
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
215,
221
]
} |
the rise in blood glucose occurred in the absence of changes in plasma glucagon and insulin and in the face of a 15 % decline in endogenous glucose production ( as measured by infusion of [ 3- ( 3 ) h ] glucose ) . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
9,
25
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
203,
210
]
} |
the cyclic amp analogue , 8-bromo cyclic amp , produced an increase in the p ( f ) of normal ccts closely comparable to that observed with vasopressin . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
4,
14
]
} | {
"id": "C0000661",
"name": "8-bromo cyclic amp",
"pos": [
26,
44
]
} |
it is present in plasma as a zymogen and is converted to a serine protease , factor ixabeta , by factor xia ( activated plasma thromboplastin antecedent ) in the presence of calcium ions . | NA | {
"id": "C0015524",
"name": "factor xia",
"pos": [
97,
107
]
} | {
"id": "C0015522",
"name": "plasma thromboplastin",
"pos": [
120,
141
]
} |
on the basis of sedimentation rates and einstein stokes radii of habp and tebg , the mol wt of the two proteins were similar in the range of 87,000-92,000 . | NA | {
"id": "C0017649",
"name": "tebg",
"pos": [
74,
78
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
103,
111
]
} |
novobiocin treatment of a resistant clinical isolate produced simultaneous loss of high-level resistance to streptomycin and kanamycin , and of resistance to penicillin-aminoglycoside synergism . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
108,
120
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
169,
183
]
} |
novobiocin treatment of a resistant clinical isolate produced simultaneous loss of high-level resistance to streptomycin and kanamycin , and of resistance to penicillin-aminoglycoside synergism . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
125,
134
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
169,
183
]
} |
these results suggest that ( a ) high-level resistance to streptomycin and kanamycin among some clinical isolates of enterococci is associated with a 45 megadalton plasmid , and ( b ) the same plasmid is also responsible for the resistance to penicillin-aminoglycoside synergism observed in these strains . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
75,
84
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
254,
268
]
} |
the results suggest that , in bartter 's syndrome , prostaglandins mediate the low urinary kinins and the high plasma bradykinin , and that urinary kallikrein , which is aldosterone dependent , does not control kinin excretion . | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
91,
97
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
118,
128
]
} |
in 24 subjects studied with the hyperglycemic clamp , blood glucose was maintained at 125 mg/dl above basal for 2 h via a primed-continuous iv glucose infusion coupled to a servo-controlled negative feedback system . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
54,
67
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
143,
150
]
} |
40 g glucose per m ( 2 ) surface area was ingested at 60 min , and the blood glucose was maintained at the steady-state hyperglycemic level . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
5,
12
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
71,
84
]
} |
mean plasma concentrations of deoxycorticosterone and cortisol were unchanged during aminoglutethimide treatment whereas those of 18-hydroxydeoxycorticosterone , progesterone , 17alpha-hydroxyprogesterone , and 11-deoxycortisol were increased as compared to pretreatment values . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
162,
174
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
177,
204
]
} |
the patient 's serum , however , did inhibit the chemotactic activity of normal zts and of column-purified c5-derived peptide ( s ) , but had no effect on the chemotactic activity of either the synthetic peptide , n-formylmethionyl leucyl-phenylalanine or a filtrate prepared from a culture of escherichia coli ( bacterial chemotactic factor ) . | NA | {
"id": "C0027229",
"name": "n-formylmethionyl leucyl-phenylalanine",
"pos": [
214,
252
]
} | {
"id": "C0008013",
"name": "chemotactic",
"pos": [
323,
334
]
} |
in group four , unidirectional chloride permeability from lumen-to-bath was measured before and after substitution of nach ( 3 ) so ( 4 ) for sodium chloride in the bath . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
31,
39
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
142,
157
]
} |
the fact that lambdalph , rather than betalph , is the predominant form in plasma suggests that the enkephalin-endorphin opiate peptides , which are contained in the `` '' missing '' '' 59-91 sequence from the betalph precursor of lambdalph , may be secreted in parallel with acth under both physiological and pathological conditions in man . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
100,
110
]
} | {
"id": "C0205753",
"name": "endorphin",
"pos": [
111,
120
]
} |
in decreasing potency , epinephrine greater than isoproterenol greater than norepinephrine greater than dopamine greater than catechol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
76,
90
]
} |
prior to 100 days of gestation , increases in allantoic fluid volume and chorio-allantoic membrane weight preceded those of fetal weight , amnio-allantoic membrane weight , and amniotic fluid volume . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
124,
136
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
164,
170
]
} |
analyses of the minor sterols , namely , the delta5- and delta7-phytosterols , have become available only recently . | NA | {
"id": "C0038323",
"name": "sterols",
"pos": [
22,
29
]
} | {
"id": "C0031866",
"name": "phytosterols",
"pos": [
64,
76
]
} |
the biological lipid levels and hyperglycaemia measured in patients of varying ages with retinal detachment have shown that : -- in 59.7 % there is a hyperlipaemia or hyperlipoproteinaemia . | NA | {
"id": "C0020473",
"name": "hyperlipaemia",
"pos": [
150,
163
]
} | {
"id": "C0020476",
"name": "hyperlipoproteinaemia",
"pos": [
167,
188
]
} |
the extracted lipoidal material with hemolytic potency is more reactive than hydrogen peroxide in a peroxide assay . | NA | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
77,
94
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
100,
108
]
} |
the pectoral muscles from normal and dystrophic chickens were reacted with rabbit antisera to troponin-c and to troponin-i , and the distribution of antibodies was determined by fluorescence microscopy of antibody-stained myofibrils and immuno-electron microscopy of separated i band segments . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
82,
90
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
149,
159
]
} |
measurements were performed with solutions of various concentrations ( 0.07-100 microgram/ml ) of free sodium fluorescein prepared from fluorescein diacetate ( fda ) , fluorescein isothiocyanate ( fitc ) and fitc bound to rabbit gamma-globulin . | NA | {
"id": "C0147866",
"name": "sodium fluorescein",
"pos": [
103,
121
]
} | {
"id": "C0060520",
"name": "fitc",
"pos": [
208,
212
]
} |
the results showed that ( a ) in the control condition the sexes did not differ in adrenaline , noradrenaline or cortisol excretion , whereas heart rate was significantly higher in the females ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
83,
93
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} |
the o-antigenic polysaccharide of phenol-water extracted salmonella typhimurium ( o antigens 4 , 12 ) lipopolysaccharide was enzymatically cleaved by phage p22 endorhamnosidase . | NA | {
"id": "C0069180",
"name": "o antigens",
"pos": [
82,
92
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
102,
120
]
} |
binding and activation of the first component of human complement by the lipid a region of lipopolysaccharides . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
73,
80
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
91,
110
]
} |
evidence is presented to show that the critical viral antigen is expressed before the spleen cells are experimentally stimulated by antigen . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
48,
61
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
132,
139
]
} |
alternatively , we used 'multispecific ' indicator cells , e.g . erythrocytes coated with antibody to fab and monospecific developers , e.g . antiserum to ig idiotype . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
90,
98
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
142,
151
]
} |
epinephrine and norepinephrine ( 10 micron ) , glucagon ( 10 micron ) , dibutyryl cyclic amp ( 1mm ) , dexamethasone ( 1 mm and 1 micron ) , and cholera toxin ( 1 microgram/ml ) did not affect [ 14c ] acetate incorporation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
a similar proportion of tracer cholesterol was absorbed regardless of the cholesterol content of the diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
31,
42
]
} | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
74,
85
]
} |
this was associated with a reduction in the amount of very low density lipoproteins ( vldl ) and high density lipoproteins ( hdl ) , the main lipoprotein fractions present in the ascites tumor fluid . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
54,
83
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
142,
153
]
} |
all of the lipids contained in both lipoprotein fractions exhibited appreciable differences in fatty acid composition . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
11,
17
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
36,
47
]
} |
when apob is isolated under conditions that minimize artifactual proteolysis , only a single , large molecular weight protein appears on polyacrylamide gel electrophoresis in sds . | NA | {
"id": "C0003601",
"name": "apob",
"pos": [
5,
9
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
118,
125
]
} |
tryptic digestion for 1 hr at ph 7.6 with enzyme-to-protein ratios of 1:100 and 1:5 results in the liberation of approximately 10 % and 30 % of apob as smaller , water-soluble peptides . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
52,
59
]
} | {
"id": "C0003601",
"name": "apob",
"pos": [
144,
148
]
} |
thus , the different quantities of lipid bound in these various ldl must interact with apob so that the same regions of the apoprotein are exposed to the action of trypsin in these different molecular weight lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
35,
40
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
208,
220
]
} |
the labeled linoleic and arachidonic acids from the respective labeled phosphatidylcholines were found in the other glycerophospholipids . | NA | {
"id": "C1959616",
"name": "phosphatidylcholines",
"pos": [
71,
91
]
} | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
116,
136
]
} |
in view of thee findings , quantitative and qualitative data reported on biological specimens submitted to saponification in ethanol , methanol , or even in water are of questionable significance . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
125,
132
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
135,
143
]
} |
the method is based on the enzymatic hydrolysis of cholesteryl esters to free cholesterol , the oxidation of cholesterol with the liberation of hydrogen peroxide , and the reaction of this peroxide with a fluorogen to form a fluoresencet product in the presence of a peroxidase . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
51,
69
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
109,
120
]
} |
the method is based on the enzymatic hydrolysis of cholesteryl esters to free cholesterol , the oxidation of cholesterol with the liberation of hydrogen peroxide , and the reaction of this peroxide with a fluorogen to form a fluoresencet product in the presence of a peroxidase . | NA | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
144,
161
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
189,
197
]
} |
progesterone and 17alpha-hydroxyprogesterone were the major products of granulosa cells in control short-term cultures with endogenous substrates . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
0,
12
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
17,
44
]
} |
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