text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
guanosine 5'-triphosphate and its synthetic analogue 5'-guanylylimidodiphosphate ( gpp ( nh ) p ) activated adenylate cyclase in particulate preparations from the osteogenic sarcoma . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
0,
9
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
83,
95
]
} |
the steroids effective in inducing maturation have in common a c=0 ( or alpha-oh ) group at 3c and a beta-oh group at 17c in the c19-steroids , and a c=o ( or beta-oh ) group at 3c and a c=o ( or alpha-oh ) group at 20c in the c21-steroids , in addition to an delta4- or delta5-unsaturated for 5alpha-saturated configuration . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
4,
12
]
} | {
"id": "C0033006",
"name": "c21-steroids",
"pos": [
227,
239
]
} |
replication of the ss dna may involve double-stranded ( ds ) dna intermediates of one unit length as found in the virion or multiple length concatamers ( salzman & white , 1973 ; gunther & may , 1976 ; lavelle & li , 1977 ) . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
19,
25
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
38,
53
]
} |
a young child developed delayed cerebrospinal fluid ( csf ) rhinorrhea and csf leak from the eye presenting as tears . | NA | {
"id": "C0007815",
"name": "cerebrospinal fluid",
"pos": [
32,
51
]
} | {
"id": "C0023182",
"name": "csf",
"pos": [
75,
78
]
} |
flow cytometry ( fcm ) is a technique that measures the quantity of dna contained in individual nuclei and records a frequency distribution of the dna content per nucleus in the sampled cell population . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
68,
71
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
196,
197
]
} |
possible causes of occlusive arteriopathy in these cases were compression of the circle of willis by a slowly growing basal tumor , secondary artial occlusive changes by radiation therapy for a basal tumor , or vasculopathy associated with neurocutaneous syndrome . | NA | {
"id": "C0003838",
"name": "occlusive arteriopathy",
"pos": [
19,
41
]
} | {
"id": "C0042373",
"name": "vasculopathy",
"pos": [
211,
223
]
} |
the labeling of cysteine and its derivatives ( penicillamine , n-acetylcysteine , cysteine ethyl ester ) with 99tc ( 99mtc ) was studied as a model for the radiopharmaceutical preparation of tc-99m mercaptide complexes . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
16,
24
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
63,
79
]
} |
feeding experiments indicated that approximately 15 % of dietary oxalate is adsorbed in the rat intestine and that dietary oxalate accounts for about one third of the oxalic acid normally excreted in rat urine . | NA | {
"id": "C0029988",
"name": "oxalate",
"pos": [
65,
72
]
} | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
167,
178
]
} |
when the diet deficient in branched-chain amino acids contained 0.98 , 1.46 , 2.25 , 3.75 , or 5.00 % leucine , increasing leucine resulted in increased food consumption and reduced efficiency of food utilization when levels of leucine up to 3.75 % were fed . | NA | {
"id": "C0002521",
"name": "branched-chain amino",
"pos": [
27,
47
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
228,
235
]
} |
excesses of isoleucine or valine caused smaller depressions of concentrations of the other two branched-chain amino acids . | NA | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
12,
22
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
95,
121
]
} |
excesses of isoleucine or valine caused smaller depressions of concentrations of the other two branched-chain amino acids . | NA | {
"id": "C0042285",
"name": "valine",
"pos": [
26,
32
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
95,
121
]
} |
we conclude that the chick is able to adapt in part to excesses of dietary leucine and that the branched-chain amino acid antagonism may involve increased catabolism of the limiting branched-chain amino acids . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
75,
82
]
} | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
182,
196
]
} |
motor disfunction and red nuclei damage occurred only in rats fed diets lacking valine alone and not in rats fed diets lacking all three branched chain amino acids . | NA | {
"id": "C0042285",
"name": "valine",
"pos": [
80,
86
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
137,
163
]
} |
because of potentially severe hypoxemia , this study suggests that suctioning and hyperventilation are not warranted on a routine basis in infants recovering from respiratory diseases . | NA | {
"id": "C0020578",
"name": "hyperventilation",
"pos": [
82,
98
]
} | {
"id": "C0035204",
"name": "respiratory diseases",
"pos": [
163,
183
]
} |
the generation of high levels of ketones during intralipid infusion period in both groups of infants indicates that sga infants can handle ketone bodies as readily as aga infants . | NA | {
"id": "C0022634",
"name": "ketones",
"pos": [
33,
40
]
} | {
"id": "C0022631",
"name": "ketone bodies",
"pos": [
139,
152
]
} |
growth and development of the thymus is dependent on secretions from the anterior pituitary , presumably growth hormone . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
73,
91
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
105,
119
]
} |
eight hours after intraperitoneal injections of 1.0 , 2.0 , and 4.0m equiv li kg-1 , the serum and brain lithium concentrations of rats were significantly greater after lithium orotate than after lithium carbonate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
105,
112
]
} | {
"id": "C0065091",
"name": "lithium orotate",
"pos": [
169,
184
]
} |
eight hours after intraperitoneal injections of 1.0 , 2.0 , and 4.0m equiv li kg-1 , the serum and brain lithium concentrations of rats were significantly greater after lithium orotate than after lithium carbonate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
105,
112
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
196,
213
]
} |
while little serum lithium remained at 24 h after injection of 2.0 m equiv kg-1 lithium carbonate , two-thirds of the 2 h serum lithium concentration was present 24h after lithium orotate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
19,
26
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
80,
97
]
} |
while little serum lithium remained at 24 h after injection of 2.0 m equiv kg-1 lithium carbonate , two-thirds of the 2 h serum lithium concentration was present 24h after lithium orotate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
19,
26
]
} | {
"id": "C0065091",
"name": "lithium",
"pos": [
172,
179
]
} |
furthermore , the 24 h brain concentration of lithium after lithium orotate was approximately three times greater than that after lithium carbonate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
46,
53
]
} | {
"id": "C0065091",
"name": "lithium",
"pos": [
130,
137
]
} |
furthermore , the 24 h brain concentration of lithium after lithium orotate was approximately three times greater than that after lithium carbonate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
46,
53
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
130,
147
]
} |
these data suggest the possibility that lower doses of lithium orotate than lithium carbonate may achieve therapeutic brain lithium concentrations and relatively stable serum concentrations . | NA | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
76,
93
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
124,
131
]
} |
[ studies on the fate of 5-fluoro-1,3-bis ( tetrahydro-2-furanyl ) -2,4-pyrimidinedione ( fd-1 ) , a new antitumor agent . i. absorption , distribution , excretion and metabolism of fd-1 administered orally to rats ( author 's transl ) ] . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
154,
163
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
168,
178
]
} |
higher and more uniform serum erythromycin levels are obtained when erythromycin stearate tablets are given on an empty stomach together with an adequate water volume . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
30,
42
]
} | {
"id": "C0059566",
"name": "erythromycin stearate",
"pos": [
68,
89
]
} |
the natural abundance 13c-nmr spectra of tropine , atropine , scopolamine , cocaine , atropine methonitrate , and dl-tropic acid were determined at 22.63 mhz . | NA | {
"id": "C0004259",
"name": "atropine",
"pos": [
51,
59
]
} | {
"id": "C0128170",
"name": "atropine methonitrate",
"pos": [
86,
107
]
} |
a convenient spectrophotometric method was developed for the determination of epinephrine , levarterenol , isoproterenol , and methyldopa by reduction of 2,3,5-triphenyltetrazolium chloride and subsequent measurement of the formazan at 485 nm . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
78,
89
]
} | {
"id": "C0028351",
"name": "levarterenol",
"pos": [
92,
104
]
} |
the extraction of daunorubicin and doxorubicin and their hydroxyl metabolites daunorubicinol and doxorubicinol was studied using chloroform-1-pentanol ( 9:1 ) as the organic phase . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
18,
30
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
97,
108
]
} |
the hydrolysis of etazolate hydrochloride , an inhibitor of cyclic nucleotide 3',5'-monophosphate phosphodiesterase that degrades cyclic adenosine 3',5'-monophosphate ( cyclic amp ) to adenosine 5'-monophosphate , and related compounds was studied by pmr and mass spectrometry . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
169,
179
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
185,
196
]
} |
three lots of meperidine hydrochloride , seven lots of meperidine tablets , and 41 lots of meperidine injectables were examined for impurities by tlc . | NA | {
"id": "C0353148",
"name": "meperidine hydrochloride",
"pos": [
14,
38
]
} | {
"id": "C0025376",
"name": "meperidine",
"pos": [
91,
101
]
} |
after the determination of the disruptive effects of single injections of cocaine or d-amphetamine on milk intake , rats were injected daily with either 16 mg/kg of cocaine 15 minutes before the session , 16 mg/kg of cocaine immediately after the session , 2.0 mg/kg of d-amphetamine 15 minutes before the session or saline before the session . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
85,
98
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
272,
283
]
} |
patulin ( 4-hydroxy-4h-furo [ 3,2-c ] pyran-2 ( 6h ) -one ) , a carcinogenic lactone produced as a major metabolite by several fungi , inhibited the mg++-dependent na+-k+ activated adenosine triphosphatase ( atpase ) activity of mouse brain microsomal fractions with an estimated ic50 of 3.0 x 10 ( -4 ) m . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
164,
166
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
208,
214
]
} |
it was about 100 , and 50 , times more potent for inhibiting cha than acetylcholinesterase , and cholinesterase , respectively . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
70,
90
]
} | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
97,
111
]
} |
treatment of animals with cobaltous chloride caused decreases in hepatic , pulmonary and renal cytochrome p-450 , and alterations in levels of other components of microsomal mixed-function oxidases , which can alter the rate of biotransformation of certain drug substrates . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
95,
111
]
} | {
"id": "C0003927",
"name": "microsomal mixed-function oxidases",
"pos": [
163,
197
]
} |
glutathione was reduced more in mice than in rats , and more in liver than in kidney , without appearance of oxidized glutathione in either tissue . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
0,
11
]
} | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
109,
129
]
} |
we have studied the regional and subcellular distribution , functional role , and pharmacology of quinoid dihydropterin reductase ( qdpr ) and endogenous reduced pterins ( ph4 ) subserving tyrosin hydroxylase ( toh ) and tryptophan hydroxylase in the rat brain . | NA | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
197,
208
]
} | {
"id": "C0041252",
"name": "tryptophan hydroxylase",
"pos": [
221,
243
]
} |
there is a significant correlation between the regional distribution of ph4 and toh but not between ph4 and tryptophan hydroxylase or between either toh or tryptophan hydroxylase and qdpr . | NA | {
"id": "C0020364",
"name": "toh",
"pos": [
80,
83
]
} | {
"id": "C0041252",
"name": "tryptophan hydroxylase",
"pos": [
156,
178
]
} |
oxotremorine increases plasma norepinephrine from 0.62 +/- 0.07 to 3.01 +/- 0.47 ng/ml and plasma epinephrine , from 0.82 +/- 0.14 to 3.42 +/- 0.48 ng/ml , in conscious unrestrained rats . l-propranolol ( 0.5-2.5 mg/kg ) reduces tremor , and at 2.5 mg/kg is more effective than either chemical sympathectomy or adrenal demedullation . d-propranolol and sotalol are also active at 4 and 10 times the dose of l-propranolol , respectively . l-propranolol does not prevent the rise in catecholamines induced by oxotremorine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
98,
109
]
} |
compounds were devoid of tranquilizing activity and in comparison with two classical benzodiazepines , chlordiazepoxide and diazepam , they showed high toxicity and little or no effect on motor coordination , motor activity , and maximal electroshock . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
85,
100
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
103,
119
]
} |
the faecal flora of 29 healthy infants and young children was compared with that of 49 children of similar age and socio-ecomonic status with acute gastroenteritis . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
43,
57
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
87,
95
]
} |
the virulence of a protease-producing strain of psuedomonas aeruginosa was compared with that of mutants that had lost the ability to produce proteases and other extracellular enzymes . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
19,
27
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
142,
151
]
} |
inhibition of vasopressin-induced water movement is half-maximal at the following alkaloid concentrations : colchicine , 1.8 x 10 ( -6 ) m ; | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
82,
90
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
108,
118
]
} |
to investigate alterations in host defense produced by trauma , skin testing with five standard recall antigens was done on admission and weekly on 53 patients with blunt trauma and seven with penetrating missile injuries , who then were classified as normal ( n ) , 2 or more positive responses ; | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
55,
61
]
} | {
"id": "C0043253",
"name": "blunt trauma",
"pos": [
165,
177
]
} |
to investigate alterations in host defense produced by trauma , skin testing with five standard recall antigens was done on admission and weekly on 53 patients with blunt trauma and seven with penetrating missile injuries , who then were classified as normal ( n ) , 2 or more positive responses ; | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
55,
61
]
} | {
"id": "C0043254",
"name": "penetrating",
"pos": [
193,
204
]
} |
furthermore , after 9 h in bromodeoxyuridine , the recently replicated viral dna had nearly three times more rna polymerase per unit of dna than did the nonreplicated dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
71,
80
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
167,
170
]
} |
the principal rna species isolated from labeled preparations of the arenavirus pichinde usually include a large viral rna species l ( apparent molecular weight = 3.2 x 10 ( 6 ) ) , and a smaller viral rna species s ( apparent molecular weight = 1.6 x 10 ( 6 ) ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
14,
17
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
195,
204
]
} |
viral rna preparations isolated by conventional phenol-sodium dodecyl sulfate extraction often have much of their l and s rna species in the form of aggregates as visualized by either electron microscopy or oligonucleotide fingerprinting of material recovered from the top of gels ( run by using undenatured rna preparations ) . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
0,
9
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
308,
311
]
} |
circular and linear rna forms have also been seen in electron micrographs of undenatured rna preparations , although denatured viral rna preparations have yielded mostly linear rna species with few rna aggregates or circular forms . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
127,
136
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
198,
201
]
} |
thirty-three per cent patients with acute viral hepatitis , 20 % with cirrhosis and 10 % with hepatocellular carcinoma were hbs ag positive , while hbs ab was detected in 22 % cases of acute viral hepatitis and 37 % with other liver disorders . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
70,
79
]
} | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
227,
242
]
} |
most strains were resistant to ampicillin , sulbenicillin , cephaloridine , cefazokin , chloramphenicol , lincomycin , clindamycin , pipemidic acid and piperamic acid . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
106,
116
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
119,
130
]
} |
in general , the majority of the strains were resistant to several antibiotics , but almost all the strains were susceptible to ampicillin and benzylpenicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
128,
138
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
143,
159
]
} |
ice water soaked towels , fanning , thermal blanket , or immersion in an ice bath can be used . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
4,
9
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
73,
76
]
} |
we feel that great caution should be exercised in the use of immunosuppressive drugs in patients with chronic , nonfatal disorders sich as rheumatoid arthritis and sjogren 's syndrome . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
139,
159
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
164,
183
]
} |
[ adrenaline and noradrenaline content of blood and urine in bronchial asthma before and after glomectomy ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
2,
12
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
17,
30
]
} |
however , despite the high probability that positive test results represent allergic disease , some patients with clinically apparent respiratory allergy have borderline or negative test results to certain allergens , and uncommon hypersensitivities such as those elicited by drug and insect-venom allergens may be missed if antibody testing is not performed at the appropriate time following antigen exposure . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
206,
215
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
393,
400
]
} |
with these two immunoassay systems and gel chromatography , we found beta-endorphin in all 20 c.s.f . samples tested at a concentration always higher than , but with no other relationship to , that in plasma . beta-endorphin was found in c.s.f . of patients who had hypopituitarism and undetectable plasma-beta-endorphin , suggesting that it is synthesized in the brain rather in the pituitary . | NA | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
266,
281
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
384,
393
]
} |
the sequential appearance of the antibody within different immunoglobulin classes in the sera during the course of immunization was followed by passive hemagglutination ( pha ) and precipitation ( pc ) reactions and the mouse passive protection test . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
33,
41
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
59,
81
]
} |
the lipolytic activity was manifested at 5 , 15 and 26 degrees c and ph 4.0 -- 9.2 , even in the presence of high concentrations ( 0.5 -- 3 m ) of such chlorides as kcl , nacl and cacl2 . | NA | {
"id": "C0008203",
"name": "chlorides",
"pos": [
152,
161
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
171,
175
]
} |
we report about the in-vitro-sensitivity tests of 1756 enterobacteriaceae and pseudomonas strains to amikacin , gentamicin , tobramycin and sisomicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
112,
122
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
140,
149
]
} |
it was established , that amikacin is more effective than gentamicin , tobramycin and sisomicin in case of infections with klebsiella , proteus species , psuedomonas strains and enterobacter . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
58,
68
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
86,
95
]
} |
amikacin is the drug of choice against gentamicin-resistent strains , which are also not infrequently resistant to other aminoglycosides . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
39,
49
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
121,
136
]
} |
[ complex of single-stranded phage dna and protein -- a product of bacteriophage fl gene 3. distribution of gene 3 protein in the dna molecule ] . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
13,
28
]
} | {
"id": "C0012854",
"name": "dna molecule",
"pos": [
130,
142
]
} |
[ oriented complexes of nucleic acids with low-molecular weight ligands . i. anisotropy of the absorbance of dna complexes with distamycin a and its analogs ] . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
24,
37
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
109,
112
]
} |
the total content of tryptophane in the forms of tryptophanyl-enzyme and tryptophanyl adenylate enzyme complex equals 2 moles per mole of the enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
62,
68
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
96,
110
]
} |
[ reaction between synthetic fragment of histone f2al and the protamines iridine and salmine with dna ] . | NA | {
"id": "C0033603",
"name": "protamines",
"pos": [
62,
72
]
} | {
"id": "C0036107",
"name": "salmine",
"pos": [
85,
92
]
} |
the interaction of basic oligopeptides -- f2ai histone , iridine and salmine protamines synthetic fragments with dna has been studied by the methods of thermal denaturation , circular dichroism and equilibrium dialysis . | NA | {
"id": "C0036107",
"name": "salmine",
"pos": [
69,
76
]
} | {
"id": "C0033603",
"name": "protamines",
"pos": [
77,
87
]
} |
the kinetics of hydrogen exchange of collagens from different animals was studied by the radioisotopic method ( tritium ) and infrared spectroscopy ( deuterium ) . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
16,
24
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
112,
119
]
} |
the kinetics of hydrogen exchange of collagens from different animals was studied by the radioisotopic method ( tritium ) and infrared spectroscopy ( deuterium ) . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
16,
24
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
150,
159
]
} |
of femoral head necroses without concomitant diseases , prior physical effects and administration of cortisone , 91 % had hyperuricemia and 65 % hyperlipemia or dyslipidemia . | NA | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
145,
157
]
} | {
"id": "C0242339",
"name": "dyslipidemia",
"pos": [
161,
173
]
} |
several novel benzopyrene derivatives with the same gross structure and the same electronic periphery as benzo ( a ) pyrene , but with some alteration in the complete electronic structure , when tested in the ame 's salmonella/microsome test ( ta 1537 , ta 100 and ta 98 ] , were found to lack mutagenicity and , therefore , putative carcinogenicity . | NA | {
"id": "C0005082",
"name": "benzopyrene",
"pos": [
14,
25
]
} | {
"id": "C0005052",
"name": "benzo ( a ) pyrene",
"pos": [
105,
123
]
} |
the prekallikrein activator was identified as hageman-factor fragments by molecular weight ( 35,000 as estimated by gel chromatography ) , isoelectric point ( 4.2 to 4.4 ) , and inhibition by antibody to hageman factor . | NA | {
"id": "C0015527",
"name": "prekallikrein",
"pos": [
4,
17
]
} | {
"id": "C0015525",
"name": "hageman factor",
"pos": [
204,
218
]
} |
studies with 29 insulin analogues ( animal insulins and proinsulin , insulin-like growth factor and chemically modified insulins ) which vary 1,000-fold in their affinity for the receptor and in their biological potency , suggest that a discrete invariable region on the surface of the insulin monomer is responsible for including the negative cooperativity . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
56,
66
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
286,
293
]
} |
effect of cocultivation on sister chromatid exchange frequencies in bloom 's syndrome and normal fibroblast cells . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
90,
96
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
97,
107
]
} |
a prompt increase in blood glucose , serum insulin and glucagon levels was observed , but glucose and glucagon peaks were significantly higher in older non diabetic and diabetic subjects . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
18,
34
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
90,
97
]
} |
right hypochondrial pain or intermittent jaundice and negative cholecystography and i.v . cholangiography is a further indication , since ercp will reveal disease of the pancreas or bile ducts ( cholelithiasis , choledocholithiasis , sclerosing cholangitis , etc ) . | NA | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
195,
209
]
} | {
"id": "C0701818",
"name": "choledocholithiasis",
"pos": [
212,
231
]
} |
although it is not proper to separate surgical and medical treatment of thromboembolism , the authors , on the ground of their experience on 5 patients affected by massive pulmonary embolism , in 3 of whom was performed a successful embolectomy , think that heparin anticoagulation treatment is at any rate to apply for treating pulmonary embolism , but in patients in whom the shock is unresponsive to vasopressors or in whom anticoagulation therapy is controindicated , the surgical removal of pulmonary emboly , with the support of a pump oxygenator , is the treatment of choice for the acute massive pulmonary thromboembolism . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
79,
87
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
329,
347
]
} |
hypertriglyceridaemia , absence of alpha and pre beta bands on the lipoprotein electrophoresis pattern , low level of apo a , presence of abnormal lipoproteins ( beta-vldl and beta2-lp ) were observed in the early phase of acute hepatitis . | NA | {
"id": "C0023825",
"name": "pre beta",
"pos": [
45,
53
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
147,
159
]
} |
either of two once weekly quinestrol regimens is an effective as conjugated estrogens given daily in a cyclic manner and therefore offers an alternative form of exogenous estrogen therapy . | NA | {
"id": "C0014938",
"name": "conjugated estrogens",
"pos": [
65,
85
]
} | {
"id": "C0014939",
"name": "estrogen",
"pos": [
171,
179
]
} |
the somatic retardation index ( sri ) expresses as a percentage the amount by which total fetal weight lags behind normal ponderal growth in cases of iugr . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
90,
102
]
} | {
"id": "C0005910",
"name": "ponderal",
"pos": [
122,
130
]
} |
dipivalyl epinephrine appears to be a more effective epinephrine compound , in that it penetrates the cornea approximately 17 times greater than epinephrine . | NA | {
"id": "C0058415",
"name": "dipivalyl epinephrine",
"pos": [
0,
21
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
145,
156
]
} |
in contrast , the fumarate reductase activity of f. hepatica was not activated by incubation with substrate or anions and was not inhibited by oxaloacetate ( 100 micron ) . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
18,
19
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
111,
117
]
} |
a simple , less than 10-min , hplc of the lipid extract of fibroblasts ( about 2 x 10 ( 6 ) cells ) and measurement of the ratio of the area of sp peak to that of other phospholipids present in the cell-lipid extract show accumulation of sp in niemann-pick type a fibroblasts compared to normal . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
92,
96
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
264,
275
]
} |
in a series of exploratory studies to develop instruments for measuring field dependence in young children , a total of 312 japanese middle-class children , ages 5 to 6 , served as subjects . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
92,
106
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
146,
154
]
} |
mb iso-enzyme was expressed as a percentage of total cpk and a minimum figure of 4 per cent of mb isoenzyme was taken as indicative of a diagnosis of myocardial infarction . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
7,
13
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
98,
107
]
} |
when the maxam-gilbert dna sequencing method is applied to this dna , the methylated cytosine ( 5-methylcytosine ) is found to be less reactive to hydrazine than are cytosine and thymine , so that a band corresponding to that base does not appear in the pyrimidine cleavage patterns . | NA | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
96,
112
]
} | {
"id": "C0010843",
"name": "cytosine",
"pos": [
166,
174
]
} |
[ fibrin and fibrinogen degradation products ( fdp ) in renal diseases . ii . serum and urinary fdp in different morphological forms of glomerulonephritis ] . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
2,
8
]
} | {
"id": "C0163275",
"name": "fdp",
"pos": [
96,
99
]
} |
`` `` nonspecific '' '' cholinesterase ( acylcholine acylhydrolase ; ec 3.1.1.8 ) from various rat tissues has been found to exist in several stable molecular forms that appear as exact counterparts of molecular forms of acetylcholinesterase ( acetylcholine hydrolase ; ec 3.1.1.7 ) . | NA | {
"id": "C0008429",
"name": "( acylcholine acylhydrola",
"pos": [
39,
64
]
} | {
"id": "C0001044",
"name": "( acetylcholine hydrola",
"pos": [
242,
265
]
} |
the sedimentation pattern of cholinesterase was similar to that of acetylcholinesterase with a small but significant shift between the sedimentation coefficients of the corresponding forms . | NA | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
29,
43
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
67,
87
]
} |
in spite of the structural resemblance implied by their physicochemical properties , cholinesterase did not crossreact with antibodies against acetylcholinesterase . | NA | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
85,
99
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
143,
163
]
} |
the cells labeled with the fluorescent analogues were visualized with a sensitive video intensification microscopic system that enabled us to directly observe the location of the fluorescent hormone on the surface and within the living fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
236,
247
]
} |
the observations support the suggestion that it now is desirable to alter nomenclature to designate the mofe protein as nitrogenase and the fe protein as nitrogenase reductase . | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
120,
131
]
} | {
"id": "C0030016",
"name": "reductase",
"pos": [
166,
175
]
} |
we coat plastic sheets with antibody molecules , expose the sheet to lysed bacteria so that a released antigen can bind , and then label the immobilized antigen with radioiodinated antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
28,
36
]
} | {
"id": "C2350610",
"name": "immobilized",
"pos": [
141,
152
]
} |
when microinjected into normal fibroblasts , cytoplasmic extracts of cells transformed by rous sarcoma virus caused dissolution of microfilament bundles . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
31,
42
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} |
a radiolabeled polypeptide of molecular weight 35,000 is released into medium in relatively large amounts by transformed cells and in much smaller amounts by nontransformed fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
121,
126
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
173,
184
]
} |
theophylline elevated cyclic gmp concentration 3-fold both in the presence and absense of the enterotoxin , suggesting no effect of the toxin on cyclic gmp phosphodiesterase . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
94,
105
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
136,
141
]
} |
the results of the present studies indicate that the physiological switch from the synthesis of hb f to that of hb a during ontogeny can be reversed in adult nonhuman primates by conditions of erythropoietic stress known to be associated with high erythropoietin levels . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
96,
100
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
112,
114
]
} |
however , when the transformed cells were repeatedly cocultivated with three different chemically transformed and serially transplanted rat tumor cell lines ( sarcoma , carcinoma , and hepatoma ) , rapidly fibroblast-transforming `` '' sarcoma '' '' viruses ( rasv ) were recovered after each attempt . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
31,
36
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
206,
216
]
} |
preliminary experiments demonstrate that antiserum to the cellobiose-bsa conjugate is hapten-specific , and the structural features of the hapten recognized by the antibodies were established by hapten inhibition experiments . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
41,
50
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
164,
174
]
} |
also obtained from the acid hydrolysis of the group c polysaccharide are rhamnose oligosaccharides with structural identity to the group a-variant polysaccharide and with group a-variant antigenic activity . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
82,
98
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
147,
161
]
} |
the role of 250k glycoprotein in normal cell adhesion is considered and a hypothesis proposed relating changes in surface organization of the 250k glycoprotein to alterations in receptors induced by ricin selection . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
17,
29
]
} | {
"id": "C0025248",
"name": "surface",
"pos": [
114,
121
]
} |
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