text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the effects of exogenously administered histamine phosphate ( 0.1 microgram per kg of body weight per min , or 90 microgram per hour ) and endogenous histamine released by intravenous injection of 0.5 mg of compound 48/80 on alveolar membrane permeability to substances of differing molecular weight ( 60 to 20,000 daltons ) were studied using the in vivo saline-filled dog lung model . | NA | {
"id": "C0062740",
"name": "histamine phosphate",
"pos": [
40,
59
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
150,
159
]
} |
authors have studied 79 children with epilepsy with centro-temporal e.e.g . foci , taking into consideration the clinical seizure type , age at first seizure , relation and sleeping-waking cycle , personal and family history and electroencephalographic findings . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
38,
46
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
150,
157
]
} |
patients with multiple myeloma had decreased marrow mast-cell content , clearly separating them from patients with lymphoproliferative disorders and reactive lymphocytosis . | NA | {
"id": "C0026764",
"name": "multiple myeloma",
"pos": [
14,
30
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
115,
144
]
} |
activation of the kallikrein-kinin system , as indicated by increased plasma kallikrein and depleted plasma kininogen , prekallikrein , and kallikrein inhibitor , was observed in five patients with rocky mountain spotted fever . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
120,
133
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
140,
150
]
} |
baseline concentrations of lactate , pyruvate , alanine , glutamine , glutamate , proline , hydroxyproline , lysine , and aspartate were elevated ( p less than 0.01 ) , whereas citrulline and arginine were low . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
82,
89
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
92,
106
]
} |
als patients also had statistically significant elevations in cerebrospinal fluid of total basic aa , lysine , essential aa , and leucine . | NA | {
"id": "C0301714",
"name": "basic aa",
"pos": [
91,
99
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
102,
108
]
} |
the present paper is a compilation of our own results and a review of the literature concerning streptomycin , kanamycin and its semi-synthetic derivation , amikacin or bb-k8 , gentamicin , tobramycin , lividomycin , sisomicin and its semi-synthetic derivation , netilmicin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
111,
120
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
157,
165
]
} |
the present paper is a compilation of our own results and a review of the literature concerning streptomycin , kanamycin and its semi-synthetic derivation , amikacin or bb-k8 , gentamicin , tobramycin , lividomycin , sisomicin and its semi-synthetic derivation , netilmicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
177,
187
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
217,
226
]
} |
the present paper is a compilation of our own results and a review of the literature concerning streptomycin , kanamycin and its semi-synthetic derivation , amikacin or bb-k8 , gentamicin , tobramycin , lividomycin , sisomicin and its semi-synthetic derivation , netilmicin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
217,
226
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
263,
273
]
} |
cefaclor was more active than cephalexin or cephalothin against escherichia coli , salmonella , and shigella isolates but did not act against serratia , acinetobacter , indole-positive proteus , or bacteroides isolates . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
30,
40
]
} |
demonstration of synergism between trimethoprim and sulfamethoxazole against 10 nocardia isolates was found to be critically dependent upon the isolate , the duration of incubation , and the trimethoprim-sulfamethoxazole ratio . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
52,
68
]
} | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
191,
220
]
} |
the variations , negligable in the case of tem-like beta-lactamases , appeared to be important in the case of cephalosporinases and are related to an artifact which appears in pa-ief . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
52,
67
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
110,
127
]
} |
rna synthesis inhibitors are highly active ( adenine nucleosides , daunorubicin , doxorubicin , chromomycin , actinomycin d , mitomycin c ) ; | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
67,
79
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
82,
93
]
} |
the combined activity of ticarcillin and each of three aminoglycosides , gentamicin , tobramycin , and amikacin , was studied with 45 clinical isolates of pseudomonas aeruginosa . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
55,
70
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
73,
83
]
} |
sulfamethoxazole-trimethoprim and three oral cephalosporins , cefaclor , cephalexin , and cephradine , were evaluated in vitro as possible alternatives to chloramphenicol in the treatment of non-central nervous system infections due to ampicillin-resistant haemophilus influenzae . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
62,
70
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
73,
83
]
} |
sulfamethoxazole-trimethoprim and three oral cephalosporins , cefaclor , cephalexin , and cephradine , were evaluated in vitro as possible alternatives to chloramphenicol in the treatment of non-central nervous system infections due to ampicillin-resistant haemophilus influenzae . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
73,
83
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
90,
100
]
} |
at 6.25 mug/ml , 100 , 11 , and 3 % of all strains were inhibited by cefaclor , cephalexin , and cephradine , respectively . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
80,
90
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
97,
107
]
} |
also , synergistic effects of sulfamethoxazole-trimethoprim , sulfamethoxazole-erythromycin , and sulfamethoxazole-cefaclor were seen when combinations were tested against both beta-lactamase-positive and -negative strains , as determined by minimal inhibitory concentrations measured by the broth dilution method and by killing curve analyses . | NA | {
"id": "C0041044",
"name": "sulfamethoxazole-trimethoprim",
"pos": [
30,
59
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
98,
114
]
} |
at least three-quarters of the streptomyces strains produced beta-lactamase constitutively and extracellularly , mainly as penicillinases , as in the cases of those from the newly isolated strains . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
61,
75
]
} | {
"id": "C0030841",
"name": "penicillinases",
"pos": [
123,
137
]
} |
strains that were resistant to tetracycline , erythromycin , clindamycin , and lincomycin were isolated , but no penicillin- or chloramphenicol-resistant strains were obtained . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
61,
72
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
79,
89
]
} |
typical minimal inhibitory concentrations for resistant strains were 16 to 64 mug of tetracycline per ml , 64 to > 128 mug of erythromycin per ml , > /=128 mug of lincomycin per ml , and 16 to 128 mug of clindamycin per ml . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
163,
173
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
204,
215
]
} |
the results show that 77.9 and 22.7 % of the strains from the former farms were resistant to tetracycline and erythromycin-clindamycin-lincomycin , respectively . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
123,
134
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
135,
145
]
} |
abnormal conditions reported in connection with severe alpha1-at deficiency of the pizz type have been , in the newborn , cholestasis and progressive juvenile cirrhosis , and in adults , panacinar pulmonary emphysema and liver disease . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
159,
168
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
221,
234
]
} |
enthusiasm in the use of dapsome for acne conglobata and other severe acne has created an increase in the use of this drug by dermatologists . | NA | {
"id": "C0263442",
"name": "acne conglobata",
"pos": [
37,
52
]
} | {
"id": "C0001144",
"name": "acne",
"pos": [
70,
74
]
} |
changes in complement and immunoglobulins in patients with abdominal trauma and in septic patients without trauma . | NA | {
"id": "C0848377",
"name": "abdominal trauma",
"pos": [
59,
75
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} |
total hemolytic complement ( ch50 ) , conversion of c3 by inulin and cobra venom factor ( covf ) , and immunochemical levels of clq , c4 , c2 , c3 , c5 , factor b , properdin , c3b inactivator ( kaf ) , and immunoglobulins ( igs ) g , a , and m were measured in the sera of ten patients with abdominal trauma and ten medical patients with septicemia without trauma . | NA | {
"id": "C0848377",
"name": "abdominal trauma",
"pos": [
292,
308
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
358,
364
]
} |
although similar reactions have been reported with the antimicrobial sulfonamides , none has been fully described with salicylazosulfapyridine , a combination of a sulfonamide and salicylate . | NA | {
"id": "C0038760",
"name": "sulfonamides",
"pos": [
69,
81
]
} | {
"id": "C0036078",
"name": "salicylazosulfapyridine",
"pos": [
119,
142
]
} |
a 24-year-old samoan woman had rhabdomyolysis , myoglobinuria , and acute renal failure , secondary to tropical pyomyositis . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
31,
45
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
48,
61
]
} |
two forms can be distinguished : a latent one ( 65 % ) , in which the changes are predominantly electrocardiographic , and a clinical form ( 35 % ) with the features of congestive cardiomyopathy , notable for the rapidity of onset after right heart failure , the degree of cardiomegaly , the constant finding of abnormalities of ventricular repolarisation , the relative frequency of latent disorders of supra-his atrio-ventricular conduction , and the finding of elongation of the isovolumic contraction time on the phonomechanocardiogram . | NA | {
"id": "C0007193",
"name": "congestive cardiomyopathy",
"pos": [
169,
194
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
273,
285
]
} |
friedreich 's disease ( 20 cases ) in its complete form led to later development of obstructive cardiomyopathy , with a systolic ejection murmur , cardiomegaly , and abnormalities of the ecg -- left ventricular hypertrophy in the vertical axis , right ventricular and septal hypertrophy , repolarisation disorders similar to those found in coronary artery disease . | NA | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
147,
159
]
} | {
"id": "C0149721",
"name": "left ventricular hypertrophy",
"pos": [
194,
222
]
} |
in these instances , infectious aerosols , produced in various ways , are probably the most frequent causes of laboratory-associated infection . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
21,
31
]
} | {
"id": "C0022882",
"name": "laboratory",
"pos": [
111,
121
]
} |
feminine individuals ( regardless of biological gender or system of classification ) obtained less adjusted scores , and this was especially significant for males . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
48,
54
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
157,
162
]
} |
herpes simplex virus ( hsv ) -infected hairless mice with evidence of latent infection in spinal ganglia did not develop latent hsv infections in trigeminal ganglia upon reinfection in the oro-facial area . | NA | {
"id": "C0019348",
"name": "herpes simplex virus",
"pos": [
0,
20
]
} | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
128,
142
]
} |
preferential stimulation by apomorphine of inhibitory dopamine presynaptic receptors ( so-called dopamine autoreceptors ) is proposed as the most likely explanation for the observed antidyskinetic effect of this drug . | NA | {
"id": "C0206129",
"name": "presynaptic",
"pos": [
63,
74
]
} | {
"id": "C0206128",
"name": "autoreceptors",
"pos": [
106,
119
]
} |
in acute experiments on the in utero foetal lamb , angiotensin ii was a more potent pressor agent that either noradrenaline or adrenaline , and the response to angiotensin ii was not consistently modified by the combined administration of alpha and beta-adrenergic blocking agents . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
127,
137
]
} |
it is concluded that the foetus , like the adult animal , is more sensitive to angiotensin ii than to catecholamines and that the biological activities of noradrenaline , angiotensin ii , adrenaline and isoprenaline are reduced by perfusion through the foetal placenta . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
102,
116
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
203,
215
]
} |
it is concluded that the foetus , like the adult animal , is more sensitive to angiotensin ii than to catecholamines and that the biological activities of noradrenaline , angiotensin ii , adrenaline and isoprenaline are reduced by perfusion through the foetal placenta . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
155,
168
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
188,
198
]
} |
several proteins were shown to have bound both labelled species in situ by liquid scintillation counting of slices from polyacrylamide gels on which solubilised membrane protein had been electrophoretically separated . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
161,
177
]
} |
the binding of phlorizin to proteins in the same three bands as above suggested a confirmation of the conclusion that there were three membrane protein types which appeared to be involved in phlorizin-sensitive glucose-binding . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
28,
36
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
135,
151
]
} |
some aspects of the local immune response to nematode infection were examined by introducing fourth-stage trichostrongylus colubriformis larvae into thiry-vella loops in worm-free and t. colubriformis-resistant sheep . | NA | {
"id": "C0027583",
"name": "nematode infection",
"pos": [
45,
63
]
} | {
"id": "C0018889",
"name": "worm",
"pos": [
170,
174
]
} |
further purification of both the unbound poly ( a ) - rna and the bound poly ( a ) + mrna on sucrose density gradients showed that both 18s and 28s rrna were absent , being removed during the deae-cellulose chromatography step . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
54,
57
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
148,
152
]
} |
inhibition by ethanol , acetaldehyde and trifluoroethanol of reactions catalysed by yeast and horse liver alcohol dehydrogenases . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
14,
21
]
} | {
"id": "C0040983",
"name": "trifluoroethanol",
"pos": [
41,
57
]
} |
of a variety of anions tested , only nitrate and nitrite formed complexes with the enzyme ( in the low-ph form ) , giving modified molybdenum ( v ) e.p.r . spectra . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
16,
22
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
37,
44
]
} |
of a variety of anions tested , only nitrate and nitrite formed complexes with the enzyme ( in the low-ph form ) , giving modified molybdenum ( v ) e.p.r . spectra . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
16,
22
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
49,
56
]
} |
the effect of alpha-galactosidase is much greater on a glycopeptide from which the arabinose has been already removed , which indicates a steric hindrance of the galactosidase action by adjacent chains of arabinosides . | NA | {
"id": "C0002268",
"name": "alpha-galactosidase",
"pos": [
14,
33
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
162,
175
]
} |
subcellular location of precursors to small nuclear rna species c and d and of newly synthesized 5 s rna in hela cells . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
44,
55
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
101,
104
]
} |
however , the finding of similar diseases in certain patients with hereditary angioedema and sle-related syndrome who have acquired deficiency of the early components of complement supports a primary role of the c2 deficiency gene in predisposing to lupus disease in these patients . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
105,
113
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
256,
263
]
} |
pathologic and immunologic features of the spontaneous autoimmune disease of nzb and nzb/nzw f1 ( b/w ) mice resemble human sle in three major respects : formation of antibodies to nucleic acids , deposition of immune complexes containing dna in the kidney , and earlier onset of severe disease in females . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
181,
194
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
239,
242
]
} |
this syndrome is consistently correlated with abnormally elevated serum igg levels , antinuclear antibodies , anti ds- and ssdna antibodies , and circulating immune complexes , as well as depressed serum hemolytic complement . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
97,
107
]
} | {
"id": "C0003313",
"name": "circulating",
"pos": [
146,
157
]
} |
the human sle spleen antigen cross-reacts with p30 group antigen of rd-114 virus but not of feline or murine viruses . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
21,
28
]
} | {
"id": "C0003342",
"name": "antigen",
"pos": [
57,
64
]
} |
lipid and lipoprotein secretion were studied over 24 h in normal and portacaval shunted ( pcs ) fasting miniature swine after an infusion of triton wr-1339 and [ 3h ] amino acid mixture . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
10,
21
]
} |
chronic oral administration of doses of isdn of this order of magnitude results in prolonged high plasma concentrations of the parent compound , as well as higher levels of the metabolites 2-ismn and 5-ismn . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
40,
44
]
} | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
200,
206
]
} |
1 plasma concentrations of diazepam and its metabolite , desmethyldiazepam , have been measured in both in- and out-patient groups treated with diazepam for periods varying between 1 month and 10 years . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
57,
74
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
144,
152
]
} |
1 seizure control , saliva anticonvulsant concentration , prescribing habits and compliance with anticonvulsant medication have been compared in 86 epileptic subjects attending either a specialist hospital clinic or general practice surgeries . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
2,
9
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
148,
157
]
} |
1 the properties of a recently introduced digitalis glycoside , 4-beta-methyl digoxin ( medigoxin ) were compared to those of a standard digoxin preparation . | NA | {
"id": "C0012253",
"name": "digitalis glycoside",
"pos": [
42,
61
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
137,
144
]
} |
1 the properties of a recently introduced digitalis glycoside , 4-beta-methyl digoxin ( medigoxin ) were compared to those of a standard digoxin preparation . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
88,
97
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
137,
144
]
} |
comparison of the plasma level profiles of these two drugs showed that medigoxin was very rapidly absorbed with peak levels occurring within 15 -- 30 min , while digoxin produced peak levels after 45 -- 75 min . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
71,
80
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
162,
169
]
} |
the area under the plasma level-time curve produced by medigoxin was also consistently greater than that produced by digoxin , even though the medigoxin dose used was smaller . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
57,
64
]
} | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
143,
152
]
} |
quantitative comparison of these areas after adjustment to compensate for differing doses showed that medigoxin is considerably more biologically available than digoxin under study conditions ( ratio 1.6 +/- 0.25:1 ) , and comparison of quantitative urinary elimination suggested that medigoxin is eliminated in the urine to a lesser extent than digoxin and therefore it undergoes more metabolism and/or hepato-biliary elimination . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
102,
111
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
346,
353
]
} |
more direct evidence of differential involvement of platelet activation and fibrin formation should be provided by specifically measuring the products of these reactions , i.e . released platelet proteins and fibrinopeptide a . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
76,
82
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
209,
225
]
} |
all of these proteins display calcium-dependent membrane binding and the identified equilibria for protein-membrane binding are qualitatively the same for all proteins . | NA | {
"id": "C0025252",
"name": "protein-membrane",
"pos": [
99,
115
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
159,
167
]
} |
the results imply that hydrogen ( or deuterium ) attached to c-1 of 1,2-propanediol participates in the inactivation process and contributes to the expression of a kinetic isotope effect on the rate of inactivation . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
23,
31
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
37,
46
]
} |
it is proposed that anions such as sulphite convert the chromatophore atpase into a form which is a more efficient energy transducer . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
20,
26
]
} | {
"id": "C0038750",
"name": "sulphite",
"pos": [
35,
43
]
} |
the modified membrane was selectively permeable to univalent cations , but was only very sparingly permeable to anions or divalent cations . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
61,
68
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
122,
138
]
} |
the conductance of the membrane was increased up to a value of about 10-2 ohm-1/cm2 with an increase in the concentration of univalent cation , and was drastically depressed by a relatively small increase in the concentration of calcium ion or other divalent cations . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
135,
141
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
250,
266
]
} |
these acids account for 58 mol % of the fatty acids in phosphatidylcholine and phosphatidylserine , 75 mol % of the free fatty acids , and nearly 90 % of the fatty acids of lyso- and phosphatidylethanolamine . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
116,
132
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
158,
169
]
} |
cytochalasin b inhibits glucose transport in human erythrocytes by competing with glucose for the carrier on the inner surface of the cell membrane , but there is no cytochalasin site associated with the outware-facing form of the carrier . | NA | {
"id": "C0010737",
"name": "cytochalasin b",
"pos": [
0,
14
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
166,
178
]
} |
the orientation of the transport system appears to be reversed in certain other cell types : chich embryo fibroblasts , novikoff hepatoma cells and hela cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
153,
158
]
} |
due to the high protein content of these membranes , the perturbing effect of protein on acyl chain mobility may extend to virtually all the intracytoplasmic membrane phospholipid . | NA | {
"id": "C0025252",
"name": "protein",
"pos": [
16,
23
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
78,
85
]
} |
in all three dna preparations hybridisation was found to be limited to satellite dna ( rho = 1.714 g/cm3 ) and at saturation was found to reach a level of 0.16 -- 0.18 % of total dna . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
71,
84
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
179,
182
]
} |
using this method it has been demonstrated that the major phosphoprotein ( lgamma ) of mouse ascites and hamster fibroblast 60-s ribosomal subunits is an acidic protein , apparently analagous to l7/12 of escherichia coli , and not a neutral protein as previously thought . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
58,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
241,
248
]
} |
krebs ii ascites cells incubated in earle 's saline ( lacking glucose and amino acids ) contain ribosomes with proteins s6 and lgamma phosphorylated , as do ascites cells grown in the peritonea of mice or hamster fibroblasts grown in eagle 's medium . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
17,
22
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
213,
224
]
} |
these results suggest that depriving ascites cells of glucose may induce the synthesis of a protein ( or proteins ) , necessary for alteration of the pattern of phosphorylation of the ribosomal proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
105,
113
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
184,
202
]
} |
deae-sephadex analysis of the dna-binding proteins , labeled with [ 14c ] - and [ 3h ] asparate , shows that only three proteins are synthesized in cells recovering from silicate-starvation . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
30,
50
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
120,
128
]
} |
anitibodies were prepared against poly ( adenosine diphosphoribose ) of an average chain length of 40 adenosine diphosphoribose units by repeated injection of the polymer mixed with methylated albumin and adjuvants into rabbits . | NA | {
"id": "C0032403",
"name": "poly ( adenosine diphosphoribose",
"pos": [
34,
66
]
} | {
"id": "C0001461",
"name": "adenosine diphosphoribose",
"pos": [
102,
127
]
} |
the size recognition of the anti-poly ( adenosine diphosphoribose ) globulin fraction was the same for polymers composed of 4 -- 40 adenosine diphosphoribose units , but smaller oligomers were not detectible . | NA | {
"id": "C0032403",
"name": "poly ( adenosine diphosphoribose",
"pos": [
33,
65
]
} | {
"id": "C0001461",
"name": "adenosine diphosphoribose",
"pos": [
132,
157
]
} |
ef-1 can also interact with nucleic acids such as 28 s and 18 s rrna , messenger rna and dna . | NA | {
"id": "C0028606",
"name": "nucleic",
"pos": [
28,
35
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
89,
92
]
} |
60 % of the incorporated ratioactivity in phycocyanin and allophycocyanin ( in brushite column eluates ) comigrated with the subunits of these phycobiliproteins on sodium dodecyl sulfate-polyacrylamide gels . | NA | {
"id": "C0031788",
"name": "phycocyanin",
"pos": [
42,
53
]
} | {
"id": "C0070980",
"name": "phycobiliproteins",
"pos": [
143,
160
]
} |
since significant band shifts were also observed in the absorption spectra of dna in the presence of these transition metal ions , we have concluded that the differences observed between the c spectrum previously reported and that found for these ions is attributable to changes in the absorption properties of the monomers due to cation association , rather than dramatic differences in comformational properties of the c secondary structure of dna in the presence of these ions . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
331,
337
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
475,
479
]
} |
therefore , of the major casein components , beta- and k-caseins apparently play a quite unimportant role in the overall phosphorylation of whole casein by both the protein kinases tested , while alphas1-casein itself , unlabeled by casein kinase s , accounts for no more than 20 -- 30 % of 32p incorporated in the presence of casein kinase ts . | NA | {
"id": "C0054846",
"name": "casein",
"pos": [
25,
31
]
} | {
"id": "C0108555",
"name": "casein kinase ts",
"pos": [
327,
343
]
} |
circular dichroism spectral titration confirmed the stoichiometry of 1 : 1 for the m-nitrobenzeneboronic acid - subtilisin complex . m-nitrobenzeneboronic acid was shown to be useful as a reversible chromophoric probe for the catalytic site of serine proteases . | NA | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
112,
122
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
244,
260
]
} |
the effect of the adenosine triphosphate analog , 6,6'-dithiobis ( inosinyl imidodiphosphate ) , ( simp-pnp ) 2 , was tested on the ouabain-sensitive ( na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) and the ouabain-insensitive mg2+ - atpase in microsomes prepared from gill tissue of sea water-adapted rainbow trout , salmo gairdneri . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
42,
44
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
173,
193
]
} |
human renal ( na+ + k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) preparations which exhibited a non-linear reaction rate , contained high levels of membrane-bound cyclic amp-dependent protein kinase , while this latter activity was much less or absent in purified preparations . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
8,
10
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
35,
55
]
} |
the addition of cyclic amp to the atpase assay of these lipid vesicles inactivated the ( na+ + k+ ) -atpase . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
34,
40
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
89,
91
]
} |
bovine plasma factor v and factor va , the latter prepared by thrombin or venom activator action on factor v , are not inactivated by diisopropylfluorophosphate or antithrombin iii nor do they form identifiable complexes with either of these reagents . | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
27,
36
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
100,
108
]
} |
on the basis of these data , it is concluded that bovine factor v and factor va are not serine proteases . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
57,
65
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
70,
79
]
} |
the relatively large mono-unsaturated fatty acid fraction consisted predominantly of fatty acids with delta6- and delta8-unsaturation . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
26,
48
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
85,
96
]
} |
this is largely compensated for by the higher content of glu and asp ( presumably as gln and asn ) in plain filaments . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
57,
60
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
85,
88
]
} |
the samples used in the equilibrium analyses contained 100 mg hb/dl with less than 5 % ferrihemoglobin and no 2,3 -- diphosphoglycerate . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
62,
64
]
} | {
"id": "C0025635",
"name": "ferrihemoglobin",
"pos": [
87,
102
]
} |
other guanine nucleotides such as gtp , gdp , gmp , guanosine 3',5'-monophosphate and 5'-guanylylimidodiphosphate ( gmp.pnp ) also stimulated mammalian adenylate cyclase activity . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
6,
25
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
34,
37
]
} |
other guanine nucleotides such as gtp , gdp , gmp , guanosine 3',5'-monophosphate and 5'-guanylylimidodiphosphate ( gmp.pnp ) also stimulated mammalian adenylate cyclase activity . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
6,
25
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
40,
43
]
} |
other guanine nucleotides such as gtp , gdp , gmp , guanosine 3',5'-monophosphate and 5'-guanylylimidodiphosphate ( gmp.pnp ) also stimulated mammalian adenylate cyclase activity . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
6,
25
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
116,
119
]
} |
other guanine nucleotides such as gtp , gdp , gmp , guanosine 3',5'-monophosphate and 5'-guanylylimidodiphosphate ( gmp.pnp ) also stimulated mammalian adenylate cyclase activity . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
34,
37
]
} | {
"id": "C0018366",
"name": "gmp.pnp",
"pos": [
116,
123
]
} |
stimulation of rat lung and liver adenylate cyclase activities with 1-isoproterenol was potentiated by either gtp4 or gmp.pnp , thus indicating that gtp4 resembles other guanine nucleotides in their capacity to increase the sensitivity of adenylate cyclase to beta-adrenergic agonists . | NA | {
"id": "C0018352",
"name": "gtp4",
"pos": [
110,
114
]
} | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
170,
189
]
} |
thyroxine treatment leads to a decrease in the level of vitamin a carrier proteins , retinol-binding protein and prealbumin-2 in plasma and liver . | NA | {
"id": "C0007292",
"name": "carrier proteins",
"pos": [
66,
82
]
} | {
"id": "C0035342",
"name": "retinol-binding protein",
"pos": [
85,
108
]
} |
monosaccharide analysis revealed the following sugar composition : d-galactose/n-acetyl-d-galactosamine/sialic acid 1 : 1 : 1 and 1 : 1 : 2 for apolipoprotein c-iii1 and apolipoprotein c-iii2 , respectively . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
0,
14
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
47,
52
]
} |
monosaccharide analysis revealed the following sugar composition : d-galactose/n-acetyl-d-galactosamine/sialic acid 1 : 1 : 1 and 1 : 1 : 2 for apolipoprotein c-iii1 and apolipoprotein c-iii2 , respectively . | NA | {
"id": "C0052190",
"name": "2",
"pos": [
138,
139
]
} | {
"id": "C0003594",
"name": "apolipoprotein c",
"pos": [
170,
186
]
} |
the hela cells also contain an adenylate cyclase which is activated by ( - ) -isoproterenol greater than ( - ) -epinephrine greater than ( - ) -norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
112,
123
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
144,
158
]
} |
the adenylate cyclase of hela is also activated by guanyl-5'-ylimidodophosphate ( gpp ( nh ) p ) , a nonhydrolyzable analogue of gtp . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
82,
94
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
129,
132
]
} |
the minimum detectable dose of purified human follitropin was 0.6 ng , and human urinary and pituitary follitropin , ovine follitropin and pregnant mare serum gonadotropin reacted in the assay with equivalent slopes . | NA | {
"id": "C0016774",
"name": "human follitropin",
"pos": [
40,
57
]
} | {
"id": "C0733758",
"name": "follitropin",
"pos": [
123,
134
]
} |
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