text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the potencies of highly purified pregnent mare serum gonadotropin and highly purified human follitropin were similar in the radioligand-receptor assay , consistent with the follitropin bioactivity of the equine gonadotropin . | NA | {
"id": "C0016774",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C0733758",
"name": "follitropin",
"pos": [
173,
184
]
} |
the linkage between mucopolysaccharide and protein moieties of the proteoglycan appeared not to be an o-glycosidic bond , which is common among other proteoglycans such as proteochondroitin sulphate and proteodermatan sulphate . | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
150,
163
]
} | {
"id": "C0033689",
"name": "proteochondroitin sulphate",
"pos": [
172,
198
]
} |
it did not possess proteolytic , tosyl-l-arginine methyl ester esterase , phosphodiesterase and alkaline phosphomonoesterase activities of the crude venom . | NA | {
"id": "C0014894",
"name": "esterase",
"pos": [
63,
71
]
} | {
"id": "C0031640",
"name": "phosphodiesterase",
"pos": [
74,
91
]
} |
these apoprotein changes were most faithfully reproduced when chylomicrons were incubated with the rat hdl fraction , although incubations of chylomicrons with rat lipoprotein-free plasma showed that arginine-rich apoprotein could readily associate with chylomicrons without concomitant changes in chylomicron lipid constituents . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
164,
175
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
298,
309
]
} |
it is found that the ficoll-dextran-40 system is characterized by a number of advantages as compared with the common dextran-polyethylene glycol system or the others systems under study . | NA | {
"id": "C0011793",
"name": "dextran-40",
"pos": [
28,
38
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
117,
124
]
} |
the epithelioid circular glomerular cells secrete a collagen with a single size of chain ( possibly type iv ) with a high ratio of hydroxyproline to proline , hydroxylysine to lysine , and 11 -- 17 % of hydroxyproline as the 3-isomer . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
138,
145
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
203,
217
]
} |
the smooth muscle-like rhomboid glomerular cells secrete collagen with a chain pattern suggesting types iii and i collagen , distinct from that found in the media of fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
166,
177
]
} |
h2o2 caused inhibition of superoxide dismutase activity of lens extract , and this inhibition was potentiated by the catalase inhibitor 3-amino-1h-1,2,4-triazole ( 3-aminotriazole ) or nan3 . | NA | {
"id": "C0040880",
"name": "triazole",
"pos": [
153,
161
]
} | {
"id": "C0002602",
"name": "aminotriazole",
"pos": [
166,
179
]
} |
the presumptive retinal myosin possesses a major component which has a mobility in sodium dodecyl sulphate polyacrylamide gel electrophoresis similar to that of the heavy chain of bovine skeletal muscle myosin . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
24,
30
]
} | {
"id": "C0027100",
"name": "heavy chain",
"pos": [
165,
176
]
} |
75 % of the globulins after 4 weeks , it can be concluded that propylthiouracil inhibits the formation of the 27-s iodoprotein and that a structurally altered and iodine-poor thyroglobulin fraction is accumulated in the follicle lumen . | NA | {
"id": "C0017649",
"name": "globulins",
"pos": [
12,
21
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
175,
188
]
} |
taking 5 cations : li+ , na+ , k+ , rb+ , cs+ as a model the existence of 16 lines of membrane ionic specificity out of 120 possible is predicted . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
9,
16
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
95,
100
]
} |
on the basis of 4 anions : f -- , cl -- , br -- , i -- the existence of 8 lines out of 24 possible is predicted . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
18,
24
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
85,
86
]
} |
on the basis of 4 anions : f -- , cl -- , br -- , i -- the existence of 8 lines out of 24 possible is predicted . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
18,
24
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
106,
107
]
} |
in the group of the aerobic hydrogen-oxidizing bacteria so far two types of hydrogenases have been encountered , a nad-reducing , soluble enzyme ( h2 : nad oxidoreductase ) and a membrane-bound enzyme unable to reduce pyridine nucleotides . | NA | {
"id": "C0020284",
"name": "hydrogenases",
"pos": [
76,
88
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
156,
170
]
} |
the beta-adrenergic antagonist alprenolol competitively inhibits the effects of isoproterenol , epinephrine and norepinephrine , having no effect on the enzyme activation by glucagon and histamine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
96,
107
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} |
the catecholamine-forming and metabolizing enzyme tyrosine hydroxylase , dopa decarboxylase , dopamine-beta-hydroxylase , phenylethanolamine n-methyltransferase , and catecholamine-o-methyltransferase , as well as the endogenous inhibitor of dopamine-beta-hydroxylase were compared in the brains of schizophrenics and controls . | NA | {
"id": "C0031397",
"name": "phenylethanolamine",
"pos": [
122,
140
]
} | {
"id": "C0025831",
"name": "methyltransferase",
"pos": [
183,
200
]
} |
we have noted that the physiological role of isozymes is far from being clearly understood , even for the most studied enzyme with multiple molecular forms , lactic dehydrogenase . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
45,
53
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
119,
125
]
} |
when only one molecule of bilirubin is bound to albumin ( without bilirubin overload ) , no displacement of bilirubin is observed , even if the protein binds as much as 6 molecules of free fatty acids . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
48,
55
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
144,
151
]
} |
the cellular composition of the spleen from cba mice was investigated two days after administration of increasing doses of hydrocortisone acetate ( hc ) , this using the presence of surface-immunoglobulin and the electrophoretic mobility as criteria for identification of lymphocyte populations . | NA | {
"id": "C0063077",
"name": "hydrocortisone acetate",
"pos": [
123,
145
]
} | {
"id": "C0020268",
"name": "hc",
"pos": [
148,
150
]
} |
the direct immunofluorescent technique gives better results than peroxidase staining : 2 ) in myeloproliferative disorders immunoglobulins ( especially g ) are more frequent and more often associated with a myelofibrosis than in other hemopathies , and 3 ) the more pronounced the fibrosis the more frequent the immunoglobulin deposits , except at the osteomyelosclerosis stage . | NA | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
94,
122
]
} | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
207,
220
]
} |
the diffusion coefficient of human hemoglobin is 4.5 x 10 ( -7 ) cm ( 2 ) s ( -1 ) at a hemoglobin concentration of 9.7 g/100 ml , and falls to 0.14 x 10 ( -7 ) cm ( 2 ) s ( -1 ) at a hemoglobin concentration of 43.0 g/100 ml . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
35,
45
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
203,
204
]
} |
the effect of temperature on the interfacial behavior of uracil , thymine and 1,5-dimethyluracil has been used to characterize the thermodynamics of adsorption of these compounds at a mercury electrode-aqueous electrolyte interface . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
57,
63
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
66,
73
]
} |
the most objective and sensitive criteria of the stress situation evaluation were decrease of testosterone and dihydrotestosterone level , increase of pregnenolone concentration , as well as of 17-alpha-hydroxypregnenolone , 17alpha-hydroxyprogesterone in the blood plasma . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
151,
163
]
} | {
"id": "C0376260",
"name": "17-alpha-hydroxypregnenolone",
"pos": [
194,
222
]
} |
the data obtained indicated alteration of the fibroblast membrane function in systemic scleroderma which could underlay the change in the metabolic activity of these cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
166,
171
]
} |
the antibodies to dna isolated from the immune sera by the immunosorbent produced an analogous effect . gamma-globulin from the sera of intact animals and immune sera after the removal of antibodies to denatured dna from them produced a different effect . gamma-globulin in a concentration of 0.28 and 5 mg failed to influence the colony-formation of 2.10 ( 5 ) explanted nucleus-containing cells , by stimulated the colony growth when added in a concentration of 15 mg . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
40,
51
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
188,
198
]
} |
in used concentrations ( up to 0.4 mmol ) all phenothiazines ( promethazine , phenethazine , chlorpromazine , methylene blue ) had hra . | NA | {
"id": "C0031436",
"name": "phenothiazines",
"pos": [
46,
60
]
} | {
"id": "C0025746",
"name": "methylene",
"pos": [
110,
119
]
} |
stromal fibroblasts from the monolayer cultures of the rabbit thymus , spleen , and bone marrow when added to suspension cultures of non-adherent rabbit spleen cells had a significant effect on the response of the plaque-forming cells ( pfc ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
8,
19
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
229,
234
]
} |
thymus-derived stromal fibroblasts irradiated by 5000 r influenced the pfc response in the same way as non-irradiated cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
23,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} |
during the erectile state of burn shock the elimination of adrenaline and noradrenaline took place , while during the torpid one further release of the granule content occurred exclusively on account of adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
74,
87
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
203,
213
]
} |
these malignant proliferations may supervent in all types of immune deficiencies but are more frequent in the wiskott-aldrich syndrom , ataxia telangiectasia and variable immunodeficiencies . | NA | {
"id": "C0021051",
"name": "immune deficiencies",
"pos": [
61,
80
]
} | {
"id": "C0009447",
"name": "variable immunodeficiencies",
"pos": [
162,
189
]
} |
adenosine 5 ' -- triphosphate ( atp ) , adenosine 5'-monophosphate ( amp ) and cyclic adenosine 3',5'-monophosphate ( cyclic amp ) had similar depressant actions . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
0,
11
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
118,
128
]
} |
4 dibuyryl cyclic amp ( 100 micron ) and agents which increase intracellular cyclic amp were not depressants , suggesting that the action of adenosine was not cyclic amp-mediated . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
11,
21
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
166,
169
]
} |
from this conformity we propose that the parameters evaluated by us from action potential records could be used for a qualitative analysis of the action of catecholamines on pacemaker potassium current and ca influx.4 the effects of the isomers of a new drug , 1-isopropylamino-3 ( 4'hydroxyphenoxy ) -propan-2-ol ( ihp ) , were evaluated in the same way as those of isoprenaline . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
156,
170
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
367,
379
]
} |
6 in atria inhibition of neuronal uptake by desipramine or cocaine led to supersensitivity to ( - ) -noradrenaline but not to ( - ) -adrenaline or ( +/- ) -isoprenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
101,
114
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
133,
143
]
} |
while 5-ht and dopamine appear to be involved in the control of motor behaviour , the precise relationship between these serotoninergic and dopaminergic systems in this respect is unclear . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
15,
23
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
140,
152
]
} |
among the species stable enough at -188 degrees c to be identified were hydrogen atoms , phosphate radicals , and oxygen anion radicals . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
89,
98
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
121,
126
]
} |
the three-dimensional structures of the bacterial serine proteases sgpa , sgpb , and alpha-lytic protease have been compared with those of the pancreatic enzymes alpha-chymotrypsin and elastase . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
50,
66
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
185,
193
]
} |
however , immunoelectrophoresis of whole serum revealed only an associated form of the liporpotein having pre-beta mobility ( i.e. , vldl ) , suggesting that the presence of discrete lipoproteins in isolated vldl , each containing a single apoprotein family , may represent ultracentrifugal artifacts . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
183,
195
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
208,
212
]
} |
vldl isolated by ultracentrifugation from perfusate of normal and hypercholesterolemic livers contained only associated lipoprotein complexes made up of apo-b , apo-c , and apo-e in the former but only apo-b and apo-e in the latter . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
0,
4
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
120,
131
]
} |
these data suggest that normal vldl are secreted as lipoprotein complexes containing apo-b , apo-c , and apo-e , which may become destabilized in the circulation . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
31,
35
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
52,
63
]
} |
zinc absorption from a test dose of ( 65zn ) zinc chloride was increased in mice with a high capacity to absorb iron induced by a low-iron diet . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
0,
4
]
} | {
"id": "C0078774",
"name": "zinc chloride",
"pos": [
45,
58
]
} |
effects of thyroid status on plasma adrenaline and noradrenaline concentrations in sheep during acute and chronic cold exposure . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
51,
64
]
} |
low concentrations of naloxone or naltrexone antagonized the excitability depression produced by the three opiate agonists but not the depression produced by procaine . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
22,
30
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
34,
44
]
} |
the data show that hot water epilepsy is a benign form of reflex epilepsy occurring mainly in children . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
29,
37
]
} | {
"id": "C0270857",
"name": "reflex",
"pos": [
58,
64
]
} |
there is increasing evidence suggesting that the perceptual-cognitive experiences of people with anorexia nervosa and juvenile onset obesity may differ from those of people without eating disorders . | NA | {
"id": "C0003125",
"name": "anorexia nervosa",
"pos": [
97,
113
]
} | {
"id": "C0013473",
"name": "eating disorders",
"pos": [
181,
197
]
} |
with the advent of more effective chemotherapy an increasing incidence of central nervous system involvement in acute lymphocyte ( all ) and myelocytic leukemias ( aml ) and chronic myelocytic leukemia ( cml ) in blast crisis has become evident . | NA | {
"id": "C0023470",
"name": "myelocytic",
"pos": [
141,
151
]
} | {
"id": "C0023473",
"name": "chronic myelocytic leukemia",
"pos": [
174,
201
]
} |
measurement of the synthesis of nuclear ribosomal rna , nonpolyadenylic acid heterogeneous rna , and polyadenylic acid heterogeneous rna revealed potentiation by 2'-deoxycoformycin of the inhibitory effect of cordycepin on all species of rna , as well as on polyadenylic acid synthesis . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
32,
39
]
} | {
"id": "C0035695",
"name": "heterogeneous",
"pos": [
119,
132
]
} |
measurement of the synthesis of nuclear ribosomal rna , nonpolyadenylic acid heterogeneous rna , and polyadenylic acid heterogeneous rna revealed potentiation by 2'-deoxycoformycin of the inhibitory effect of cordycepin on all species of rna , as well as on polyadenylic acid synthesis . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
32,
39
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
238,
241
]
} |
normal tissues had high concentrations of putrescine and spermine with intermediate spermidine concentrations , whereas there was a dramatic increase in the spermine concentration in patients with hypertrophy of the prostate . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
42,
52
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
95,
109
]
} |
normal tissues had high concentrations of putrescine and spermine with intermediate spermidine concentrations , whereas there was a dramatic increase in the spermine concentration in patients with hypertrophy of the prostate . | NA | {
"id": "C0037871",
"name": "concentrations",
"pos": [
24,
38
]
} | {
"id": "C0037874",
"name": "concentration",
"pos": [
166,
179
]
} |
although not highly significant , spermidine concentrations were elevated slightly in benign hyperplasia , whereas the putrescine content was decreased compared to normal tissue . | NA | {
"id": "C0037871",
"name": "concentrations",
"pos": [
45,
59
]
} | {
"id": "C0034170",
"name": "putrescine",
"pos": [
119,
129
]
} |
if returned to normal medium after 12 days in pma , the cells fail to synthesize their two characteristic luxury molecules , and 100 % of the cells remain fibroblastic . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
56,
61
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
155,
167
]
} |
we were unable to detect to detect this new isoenzyme by polyacrylamide gel electrophoresis with activity stains or by the reported high sensitivity of this enzyme to inhibition by cysteamine s-phosphate when p-nitrophenyl phosphate is the substrate . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
44,
53
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
157,
163
]
} |
fifteen patients with no collaterals were compared with 35 patients with collaterals , and to a subset of 11 patients with very rich right-to-left collaterals , and there was no significant difference in historic or ecg evidence of old infarction , duration of angina , incidence of unstable angina , left ventricular end-diastolic pressure , cardiac index , ejection fraction , or segmental contraction abnormalities . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
261,
267
]
} | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
283,
298
]
} |
polysomal rna from tobacco leaves was prepared by a procedure which minimized contamination with nuclear rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
10,
13
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
97,
108
]
} |
the 9s and 12s rnas were found to hybridize selectively to the maxicircle sequences of the kinetoplast dna , implying that the maxicircle , and not the minicircle , represents the informational mitochondrial dna in the kinetoplast . | NA | {
"id": "C0064360",
"name": "kinetoplast dna",
"pos": [
91,
106
]
} | {
"id": "C0012929",
"name": "mitochondrial dna",
"pos": [
194,
211
]
} |
this catalog of proteins , combined with 50 additional ribosomal proteins already studied , comprises about 5 % of the coding capacity of the genome , but accounts for two thirds of the cell 's protein mass . | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
55,
64
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
194,
201
]
} |
proteins , including the ribosomal proteins , that increase in amount with increasing growth rate account for 20 % of total cell protein by weight during growth on acetate , 32 % on glucose-minimal medium and 55 % on glucose-rich medium . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
25,
43
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
129,
136
]
} |
it seems that superoxide dismutase plays the key role in protecting aerobes against o2 toxicity , but there is a whole range of ancillary mechanisms : enzymes to remove h2o2 ( catalase , peroxidases ) and hence to control formation of .oh from o2 , which requires h2o2 ; | NA | {
"id": "C0007367",
"name": "catalase",
"pos": [
176,
184
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
187,
198
]
} |
3 ' deoxycytidine , the cytidine analogue of cordycepin and selective inhibitor of pre-ribosomal rna in hela cells , has been found to be a reversible inhibitor of dna replication in rna accumulation . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
87,
100
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
183,
186
]
} |
af 2 ( 2- ( 2-furyl ) -3- ( 5-nitro-furyl ) acrylamide ) was toxic to chinese hamster v 79 cells and normal human fibroblasts in aerobic media . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} |
both hamster v 79 cells and human fibroblasts metabolized af 2 and other nitrofurans rapidly only under hypoxic conditions . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} |
human fibroblasts were more sensitive to af 2 both under aerobic conditions and in hypoxia than were v 79 cells under similar conditions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
6,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} |
beginning with an influenza-like syndrome , including fever , headache , and joint and muscle pains , the disease soon caused diarrhoea ( 81 % ) , vomiting ( 59 % ) , chest pain ( 83 % ) , pain and dryness of the throat ( 63 % ) , and rash ( 52 % ) . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
62,
70
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
189,
193
]
} |
plasma noradrenaline and adrenaline were measured in conscious rats on 50 microliter samples by a radiometric technique . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} |
polarographic micro-electrodes ( carbon fiber , o. d. 8 micron ) implanted in the rat caudate nucleus , allowed a practically continuous in vivo monitoring ( one measurement every 5 sec . ) of the extra-cellular concentration of dopamine released by striatal dopaminergic terminals . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
229,
237
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
259,
271
]
} |
polyacrylamide gel electrophoresis showed 125i-rt3 added to human serum was distributed among two proteins : albumin ( carrying 57 % of tracer rt3 ) and tbpa ) 22 % ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
98,
106
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
109,
116
]
} |
those coated with high density lipoproteins ( hdl ) or apoprotein a-i ( apo-a-i ) are agglutinated by anti-apo-a-i immunserum . | NA | {
"id": "C0003592",
"name": "apo-a",
"pos": [
72,
77
]
} | {
"id": "C0085201",
"name": "apo-a-i",
"pos": [
107,
114
]
} |
the american heart association recommends that children with elevated plasma cholesterol or triglyceride be placed on an appropriate diet in order to reduce their risk of hyperlipidemia and possibly to reduce their risk of atherosclerotic disease when they become adults . | NA | {
"id": "C0020443",
"name": "elevated",
"pos": [
61,
69
]
} | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
171,
185
]
} |
lysine was less affected by cycloleucine , but this amino acid accumulation proceeded at a rate slower than for neutral amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
52,
62
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
112,
131
]
} |
the analytical ultracentrifugation studies of serum lipoproteins of those patients showed that concentration of very low density lipoproteins was considerably increased . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
52,
64
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
112,
141
]
} |
a sensitive assay for measurement of branched-chain keto acid decarboxylation in small numbers of fibroblasts or amniotic cells grown in the wells of a microtitre plate using [ 1-14c ] leucine as substrate is described . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
122,
127
]
} |
on clofibrate , very low density lipoprotein ( vldl ) cholesterol and triglyceride concentrations fell , but the concentrations of cholesterol in low density ( ldl ) and high density ( hdl ) lipoproteins showed no consistent change . | NA | {
"id": "C0023826",
"name": "very low density lipoprotein",
"pos": [
16,
44
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
131,
142
]
} |
investigation of vestibular function in 34 patients with benign intracranial hypertension was performed and a follow-up examination 3-20 years after the primary examination , when the symptoms of intracranial hypertension had disappeared . | NA | {
"id": "C0033845",
"name": "benign intracranial",
"pos": [
57,
76
]
} | {
"id": "C0151740",
"name": "intracranial hypertension",
"pos": [
196,
221
]
} |
unlike crp , whick is a major acute phase reactant , protein sap was only slightly elevated in inflammatory and neoplastic diseases in which crp was greatly increased . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
30,
50
]
} | {
"id": "C0006560",
"name": "crp",
"pos": [
141,
144
]
} |
( 3 ) an antibody to beta2 , microglobulin , showing strong cross-reactivity with normal igg , bound nef activity before , but not after , absorption of the antiserum with igg . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
9,
17
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
157,
166
]
} |
comparison of the relative cytotoxic effector cell capabilities and the proportions of cells bearing various surface markers in human tonsil and peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
14,
17
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
145,
179
]
} |
the relative cytotoxic effector cell capabilities and the proportions of cells bearing various surface markers in human tonsil and peripheral blood mononuclear cells has been studied . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
131,
159
]
} |
tonsil mononuclear cell suspensions were incapable of mediating antibody-dependent cellular cytotoxicity against chang cells , whereas blood mononuclear cells functioned normally . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
135,
158
]
} |
the sera from seven patients with acute myelogenous leukaemia ( aml ) who had achieved a clinical remission and who were being maintained by weekly immunotherapy using irradiated allogeneic aml cells and bcg , were examined for the presence of antibodies which were lytic to autologous aml cells using either a complement- or cell-dependent assay . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
179,
189
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
326,
330
]
} |
albumin was the only protein detected in the filtrate with stirring but alpha- and beta- globulins appeared when stirring ceased . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
0,
7
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
21,
28
]
} |
maximal acid output after pentagastrin stimulation , and fasting and postprandial serum gastrin concentrations were determined in 25 normal subjects , 30 patients with corpus gastric ulcers , 10 patients with prepyloric ulcers and 30 patients with both duodenal and gastric ulcers . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
26,
38
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
88,
95
]
} |
there was a dose dependency between cgf concentration , the lowered uptake of dg , cl and aib , and cell protein content . | NA | {
"id": "C0225369",
"name": "cgf",
"pos": [
36,
39
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
100,
104
]
} |
the effect of cgf on dg transport and dthd incorporation into dna was not immediate but required prior exposure of the cells to cgf . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} | {
"id": "C0225369",
"name": "cgf",
"pos": [
128,
131
]
} |
this and the reported finding that pituitary fibroblast growth factor ( fgf ) , increases amino acid transport in other cells suggests that the biological specificity of cgf may not be identical to that of fgf . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
120,
125
]
} | {
"id": "C0225369",
"name": "cgf",
"pos": [
170,
173
]
} |
thus , intravascular protein tracers such as evans ' blue-albumin , 125i-labelled albumin , horseradish peroxidase ( ed 1.11.1.7 ) and alpha-mannosidase ( ec 3.2.1.24 ) are allowed into the brain , and uptake of [ 3h ] norepinephrine ( noradrenaline ) is increased more than twofold above a normal rate of accumulation by brain . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
21,
28
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
82,
89
]
} |
blood-csf barrier impairment and immune reactions were detected by immunochemical determination of albumin and igg on lc partigen plates , the assay range of the plate being sufficient only for these proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
99,
106
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
200,
208
]
} |
eleven incubations of minced human fetal adrenal tissue from two fetuses at midtrimester of pregnancy terminated for socio-economic reasons , were performed for different periods of time with labelled pregnenolone , progesterone , 17alpha-hydroxyprogesterone and deoxycorticosterone ( doc ) . | NA | {
"id": "C0032980",
"name": "midtrimester",
"pos": [
76,
88
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
92,
101
]
} |
eleven incubations of minced human fetal adrenal tissue from two fetuses at midtrimester of pregnancy terminated for socio-economic reasons , were performed for different periods of time with labelled pregnenolone , progesterone , 17alpha-hydroxyprogesterone and deoxycorticosterone ( doc ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
216,
228
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
231,
258
]
} |
neither preproinsulin nor further processing of the proinsulin to insulin can be detected in the oocytes . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
11,
21
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
66,
73
]
} |
glutamic acid and proline accounted for nearly one third of the residues , tyrosine , tryptophan and cysteine were absent , and the content of aromatic amino acids was very low . | NA | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
75,
83
]
} | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
143,
163
]
} |
glutamic acid and proline accounted for nearly one third of the residues , tyrosine , tryptophan and cysteine were absent , and the content of aromatic amino acids was very low . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
86,
96
]
} | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
143,
163
]
} |
inhibitor-1 from rabbit skeletal muscle was phosphorylated by protein kinase dependent on adenosine 3 ' :5'-monophosphate ( cyclic amp ) , but not by phosphorylase kinase or by glycogen synthetase kinase-2 . | NA | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
62,
76
]
} | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
150,
170
]
} |
the phosphorylase phosphatase , phosphorylase kinase phosphatase and glycogen synthetase phosphatase activities of protein phosphatase-iii were inhibited in an identical manner by inhibitor-1 . | NA | {
"id": "C0031714",
"name": "phosphorylase phosphatase",
"pos": [
4,
29
]
} | {
"id": "C0031686",
"name": "phosphatase",
"pos": [
123,
134
]
} |
the penicillin-binding proteins were then solubilized and applied to a column of ampicillin-affinose to which only protein 1 was bound as the other penicillin-binding proteins still had benzylpenicillin bound to them . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
81,
91
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
186,
202
]
} |
the complex breaks down , obeying first-order kinetics , with a half-life of 16 min at 35 degrees c , a value identical to that obtained with the membrane-bound protein . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
46,
54
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
64,
73
]
} |
insulin secretion in growth hormone-deficient children and the effect of the sulfonylurea drug glibenclamide on linear growth . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
77,
89
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
95,
108
]
} |
the effect of glucose on insulin release and the influence of glibenclamide on linear growth were determined in five growth hormone ( sth ) deficient children who were treated with human growth hormone . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
117,
131
]
} | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
181,
201
]
} |
a review of the literature shows that gh secretion is consistently depressed in cushing 's disease of central origin and in cushing 's syndrome due to adrenal carcinoma . | NA | {
"id": "C0001622",
"name": "cushing 's disease",
"pos": [
80,
98
]
} | {
"id": "C0010481",
"name": "cushing 's",
"pos": [
124,
134
]
} |
40 diabetic children ( 20 female , 20 male , mean age 8.5 ys , ranging from 0.8 to 14.3 ys ) , were treated with either of two purified porcine insulin preparations , komb-insulin cs ( hoechst ) `` '' cs '' '' : n = 21 , and semilente mc ( novo ) `` '' mc '' '' : n = 19 , the latter being further purified by ion exchange chromatography . | NA | {
"id": "C0724601",
"name": "porcine insulin preparations",
"pos": [
136,
164
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
172,
179
]
} |
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