text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it is shown that microcrystals of a variety of paramagnetic heme proteins , suspended in approximately 90 % saturated ( nh4 ) 2so4 , may be perfectly aligned by an intense static external magnetic field , h0 , due to the large anisotropy in the magnetic susceptibility of the protein caused by the paramagnetic center . | NA | {
"id": "C0018974",
"name": "heme proteins",
"pos": [
60,
73
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
276,
283
]
} |
the majority of the rna synthesized by the transcription complex from endogenous dna is complementary to the dna strands directing the synthesis of the large and small ribosomal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
20,
23
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
168,
181
]
} |
the older children in the series had the worst prognosis , as did children with other associated upper-extremity injuries , usually on the medial aspect of the elbow . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
4,
18
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
66,
74
]
} |
patients with nephrotic syndrome ( ns ) lose 25-hydroxyvitamin d3 ( 25ohd3 ) in the urine and have low blood levels of this metabolite . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
45,
65
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
68,
74
]
} |
the effect of histamine and histamine h2 receptors on secretion off parathyroid hormone ( pth ) was evaluated by 1 ) adding histamine phosphate ( with or without the histamine h2 receptor antagonist , cimetidine ) to the medium in in vitro incubation studies with bovine parathyroid tissue , 2 ) infusing histamine into rats , and 3 ) infusing the histamine h1 receptor antagonist , diphenhydramine , or cimetidine into normal men and patients with primary hyperparathyroidism . | NA | {
"id": "C0062740",
"name": "histamine phosphate",
"pos": [
124,
143
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
348,
357
]
} |
several other growth factors , such as somatomedins a and c and nonsuppressible insulin-like activity ( soluble ) , have been shown to be dependent on the circulating levels of pituitary gh . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
39,
51
]
} | {
"id": "C0028318",
"name": "nonsuppressible insulin-like",
"pos": [
64,
92
]
} |
characterization of the human insulin receptor solubilized from cultured fibroblast and erythrocyte cell membrane preparations . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
73,
83
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
100,
104
]
} |
spontaneous infarction of pituitary microadenomas may be subclinical , resulting in improvement of pituitary hormone hypersecretion without impairment of other anterior pituitary hormone secretion . | NA | {
"id": "C0032015",
"name": "pituitary hormone",
"pos": [
99,
116
]
} | {
"id": "C0032016",
"name": "anterior pituitary hormone",
"pos": [
160,
186
]
} |
the steroidogenic activity of human fetal testes during early and midgestation was monitored by analyzing 58 individual fetal testes ( aged 6-20 weeks of pregnancy ) for endogenous pregnenolone ( p5 ) , progesterone , 17-hydroxyprogesterone , dehydroepiandrosterone , androstenedione , testosterone ( t ) and estradiol . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
203,
215
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
218,
240
]
} |
the levels of all of the c-19 steroids measured decreased clearly between weeks 14-20 of gestation , whereas those of the c-21 steroids , p5 , progesterone , and 17-hydroxyprogesterone , remained relatively high . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
143,
155
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
162,
184
]
} |
the induction of somatomedin by growth hormone has been difficult to study in vitro , however , because no organ containing a high concentration of somatomedin has been identified . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
17,
28
]
} | {
"id": "C0021666",
"name": "a",
"pos": [
161,
162
]
} |
growth hormone stimulated immunoreactive somatomedin production in a dose-dependent manner : 5 ng hgh/ml = 0.1 u/ml per 10 ( 5 ) cells ; | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
0,
14
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
98,
101
]
} |
media that had been exposed to human fibroblasts stimulated dna synthesis in balb/c 3t3 fibroblasts ( a cell type that does not produce somatomedin ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
37,
48
]
} | {
"id": "C0007634",
"name": "cell type",
"pos": [
104,
113
]
} |
a monoclonal antibody ( anti-b1 ) specific for a unique b cell surface differentiation antigen was used to characterize the malignant cells from patients with leukemias or lymphomas . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
2,
21
]
} | {
"id": "C0768182",
"name": "anti-b1",
"pos": [
24,
31
]
} |
fibroblasts cultured from human tissues had the highest activity ( 0.56-1.15 mumol/h per 10 ( 6 ) cells ) , more than endothelial cells cultured from human pulmonary arteries . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
130,
135
]
} |
hydrocortisone changed pcp activity in fibroblasts in parallel with changes in beta-glucuronidase activity and cell-protein concentration ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
111,
115
]
} |
the ability of heparin glycosaminoglycan to prevent formation of the properdin-stabilized amplification c3 convertase is independent of antithrombin binding activity and requires substitution of the amino sugar and a degree of oxygen ( o ) -sulfation which could be on the uronic acid or the amino sugar . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
15,
22
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
23,
40
]
} |
preparations of heparin glycosaminoglycan isolated by different techniques from different species ( rat , human , and porcine ) exhibited an equivalent capacity to inhibit generation of the amplification c3 convertase . | NA | {
"id": "C0019134",
"name": "preparations",
"pos": [
0,
12
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
24,
41
]
} |
n-resulfation of n-desulfated and o-desulfated heparin did not restore any activity , thus indicating that o-sulfation and n-substitution represent independent , critical structural requirements for the anticomplementary activity of heparin glycosaminoglycan . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
47,
54
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
241,
258
]
} |
this is in addition to those with familial polyposis ( p < 0.001 ) , and extends this marker of colon cancer susceptibility to a second population group with hereditary predisposition to colonic neoplasia . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
109,
123
]
} | {
"id": "C0314657",
"name": "hereditary predisposition",
"pos": [
158,
183
]
} |
when purified sarcoid lung t cells from patients with high proportions of t lymphocytes in their lavage fluid were co-cultured with blood mononuclear cells from normal individuals ( without added antigens or mitogens ) , the b lymphocytes in these normal mononuclear cell suspensions were induced to differentiate into immunoglobulin-secreting cells ( p < 0.01 ) . | NA | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
132,
155
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
242,
245
]
} |
four patients with histories of systemic anaphylaxis or angioedema and urticaria after ingestion of sesame seed or sesame oil-containing products were studied for anti-sesame seed extract ige by the radioallergosorbent test ( rast ) . | NA | {
"id": "C0002994",
"name": "angioedema",
"pos": [
56,
66
]
} | {
"id": "C0042109",
"name": "urticaria",
"pos": [
71,
80
]
} |
methacholine inhalation challenges were performed in five groups : 14 patients with history of farmers ' lung disease ( fld ) , nine well farmers with precipitating antibodies to micropolyspora faeni antigen , ii normal subjects , 12 asthmatic patients , and 10 patients with interstitial lung disease ( ild ) other than hypersensitivity pneumonitis . | NA | {
"id": "C0206062",
"name": "interstitial lung disease",
"pos": [
276,
301
]
} | {
"id": "C0002390",
"name": "hypersensitivity pneumonitis",
"pos": [
321,
349
]
} |
however , the methacholine sensitivity of fld patients was indistinguishable from a group of patients with ild and significantly less than the asthmatic group . | NA | {
"id": "C0024115",
"name": "the",
"pos": [
10,
13
]
} | {
"id": "C0206062",
"name": "ild",
"pos": [
107,
110
]
} |
in contrast , significant priming to an irritant , ammonia gas ( nh3 ) , could not be unequivocally demonstrated over a similar period of time in these same subjects under the conditions employed . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
51,
58
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
59,
62
]
} |
tg cells fail to vigorously proliferate in response to con a or irradiated allogeneic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
3,
8
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
75,
91
]
} |
moreover , the response of tnong populations to con a and allogeneic cells is enhanced compared with unseparated t cells , suggesting active suppression by tg cells . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
58,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
159,
164
]
} |
the immune complexes were sheep red cells sensitized with mouse igm antibody or antibody and complement . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
4,
20
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
80,
88
]
} |
this finding suggests that epitopes shared by nucleic acid antigens can account for some of the serologic diversity in lupus serum . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
27,
35
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
59,
67
]
} |
hybridoma antibodies reacting to antigens of the h-2b haplotype reveal genetic control of isotype expression . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
10,
20
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
90,
97
]
} |
the same correlation with respect to isotype expression was found , indicating that hybridoma antibodies reflect normal antibody responses and suggesting h-2-linked control of this expression . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
37,
44
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
94,
104
]
} |
experiments of absorption of nk cells on target cell monolayers and analysis of cytotoxicity at the single-cell level in semisolid medium demonstrate that nk cells bind to both if-treated and untreated fibroblasts but lyse only the latter . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
32,
36
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
202,
213
]
} |
by utilizing lipopolysaccharide ( lps ) -stimulated f1 spleen lymphoblasts as immunogens , 1 of the parents as recipient and the other parent cells for absorption of antisera , specific anti-ia.22 and 23 antibodies were produced . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
166,
174
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
204,
214
]
} |
these combined results provide strong evidence that lysis of autologous lcl cells by lymphocytes stimulated with pooled allogeneic normal cells is mediated by tc rather than nk-like cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
76,
81
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
120,
130
]
} |
the sequence of thymopoietin , a thymic hormone composed of 49 amino acids , was compared to sequences of immunoglobulins and related cellular recognition molecules . | NA | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
16,
28
]
} | {
"id": "C0040114",
"name": "thymic hormone",
"pos": [
33,
47
]
} |
the analysis of radioiodinated membrane proteins of l. tropica promastigotes revealed a simple pattern of 6 to 7 labeled major proteins and some minor ones . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
31,
48
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
127,
135
]
} |
partial cleavage of radioiodinated surface proteins by staphylococcal v-8 protease in the presence of 4.5 m urea and peptide mapping confirmed the presence of shared and isolate-specific proteins . | NA | {
"id": "C0025252",
"name": "surface",
"pos": [
35,
42
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
187,
195
]
} |
epitope-specific antibody feedback regulation of the humoral immune response against sheep erythrocytes in vitro : specific effects of anti-antigen antibody vs nonspecific t cell activities . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
0,
7
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
140,
147
]
} |
first , such antibody feedback occurred in cultures of purified and anti-lyt2 antiserum and complement-treated surface ig-positive cells in which th were substituted for by t-replacing factor . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
13,
21
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
78,
87
]
} |
these data strongly suggest that vh-restricted inhibitory activity of antibody in this system is a manifestation of epitope specificity of the antibody feedback and not of idiotype specificity , i.e. , that anti-srbc antibody acts via masking of epitopes . | NA | {
"id": "C0021013",
"name": "idiotype",
"pos": [
172,
180
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
246,
254
]
} |
overall hapten concentration in the cultures is only of significance as a consequence of epitope density and liposome concentration ; | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
8,
14
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
89,
96
]
} |
two days after the last subcutaneous injection of thymosin , nude spleens were removed , mixed with normal balb/c spleen cells , and placed into a mixed lymphocyte tumor culture ( mltc ) against allogeneic rbl 5 tumor cells . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
100,
106
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
195,
205
]
} |
this process was characterized by the novel appearance and limited duration of synthesis of many proteins , in particular of 30 , 35 , 48 , 50 , and 55 kilodalton molecules in the early days of blast transformation and subsequently of 120 , 125 , 135 , and 145 kilodalton proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
79,
88
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
272,
280
]
} |
further fractionation of the organic solvent layer with purified human serum albumin at physiologic ph ( 7.4 ) , followed by reacidification and extraction of the acidified albumin layer with the same solvent , gave a homogeneous fraction on thin-layer chromatography . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
65,
84
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
173,
180
]
} |
further evidence that the molecule identified by lyb-2 plays a critical role in the generation of antibody-forming cells ( afc ) in response to t-dependent antigen comes from the finding that lyb-2 antibody does not reduce the pfc response to the t-independent antigens trinitrophenylated ( tnp ) brucella abortus and tnp-ficoli , although elimination of lyb-2 ( + ) cells from the starting population by lyb-2 antibody and complement reduces the pfc response to t- dependent and t-independent antigens alike . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
156,
163
]
} | {
"id": "C0003340",
"name": "t-independent antigens",
"pos": [
480,
502
]
} |
rats were fed lecithins , derived from eggs or soybeans , to determine whether the fatty acid composition of the phosphatidylcholine altered choline availability . | NA | {
"id": "C0031617",
"name": "lecithins",
"pos": [
14,
23
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
113,
132
]
} |
rats were fed either a single meal containing 5 g phosphatidylcholine or a lecithin-containing diet for 3 weeks , including approximately 5 g phosphatidylcholine per day . | NA | {
"id": "C0031617",
"name": "lecithin",
"pos": [
75,
83
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
142,
161
]
} |
the effect of dietary methionine ( met ) on the biopotency of selenium ( se ) from selenite and selenomethionine ( se-met ) was studied in rats fed a 30 % torula yeast-based diet containing 0.24 % met and less than 0.02 ppm se . | NA | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
96,
112
]
} | {
"id": "C0025646",
"name": "met",
"pos": [
197,
200
]
} |
the effect of incorporated caf2 ( 2.04 % ) , naf ( 2.27 % ) and amine fluoride ( 0.71 % ) in acrylic resin plates , on bending strength and fluoride release by rinsing and immersion in synthetic saliva , was determined . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
45,
48
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
140,
148
]
} |
the most elevated release of fluoride from the naf containing -- and the most protracted from the caf2 containing -- plates may be related to the solubilities of the compounds . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
29,
37
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
47,
50
]
} |
the final dose-response curve was obtained after partial recovery of the pressor responsiveness to norepinephrine and epinephrine from phentolamine blockade . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
99,
113
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
118,
129
]
} |
2 ) sensitivity of the thallium-201 ( tl-201 ) myocardial perfusion imaging was 77 % with coronary stenosis < 50 % and 80 % with stenosis < 75 % , and specificity was 80 % and 96 % with and without inclusion of cardiomyopathy and myocarditis , respectively . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
211,
225
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
230,
241
]
} |
on the basis of complement-mediated antibody cytotoxicity assays with the use of either antiserum against mouse igm , antiserum against mouse igg , or antiserum against thy 1.2 antigen , ib cells were characterized as t-cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
36,
44
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
151,
160
]
} |
however , because the fibroblasts from some of the young asymptomatic gs and fp family members also transformed at higher efficiency than did cells from unrelated controls , long-term observation of these families is required . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
22,
33
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} |
patterns of metabolism and disposition in plasma of tumor-bearing mice after oral administration of [ 6 ( -14 ) c ] 1-hexylcarbamoyl-5-fluorouracil ( [ 6 ( -14 ) c ] hcfu ) resembled those in plasma of normal mice , but elimination of [ 6 ( -14 ) c ] hcfu and 5-fluorouracil ( fura ) was slower in tumor-bearing mice . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
12,
22
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
220,
231
]
} |
a minority of cells in the cartilaginous matrix occupied lacunar spaces and were indistinguishable from normal chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
111,
123
]
} |
the condition generally presents in males of late middle age who have pulmonary tuberculosis , although the pulmonary disease is seldom advanced . | NA | {
"id": "C0041327",
"name": "pulmonary tuberculosis",
"pos": [
70,
92
]
} | {
"id": "C0024115",
"name": "pulmonary disease",
"pos": [
108,
125
]
} |
cushing 's syndrome , an unusual group of disorders characterized by hypercortisolism , must be considered in the differential diagnosis of such common clinical problems as hirsutism , menstrual irregularity , hypertension , diabetes mellitus , and obesity . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
0,
19
]
} | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
69,
85
]
} |
for occasional moderate pain not responsive to aspirin , zomepirac may prove to be preferable to oral narcotics such as codeine , oxycodone , propoxyphene , pentazocine and meperidine . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
120,
127
]
} | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
130,
139
]
} |
this is mainly because fibroblasts are a major contaminating cell type in primary muscle cultures and these cells have no known distinctive cell-surface antigen ( s ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
23,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} |
acyclovir ( 9- [ 2-hydroxyethoxymethyl ] guanine or acv ) is a nucleoside analogue with considerable potential for the treatment of herpes simplex virus ( hsv ) infections in man . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
0,
9
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
41,
48
]
} |
the major components of this matrix include actin and four additional proteins not previously identified as cytoskeletal proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
70,
78
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
108,
129
]
} |
the integrative mechanism joins a precise site in viral dna to non-homologous sites in host dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
10,
11
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
92,
95
]
} |
fibronectin stimulates the adhesion of fibroblasts , but not epidermal cells , to collagen type iv ( ref . 7 ) and could mediate the attachment of sarcoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
129,
132
]
} |
the biosynthesis of trans-3- and trans-4-hydroxyprolines and 5-hydroxylysine in animal cells requires polypeptide proline or lysine , enzymes and cofactors including iron , and possibly involves peroxidatic intermediates . | NA | {
"id": "C0020388",
"name": "hydroxyprolines",
"pos": [
41,
56
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
114,
121
]
} |
aortic valve replacement in the third trimester of pregnancy : case report and review of the literature . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
32,
47
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
51,
60
]
} |
2 ) underweight women who gained the same amount of weight as normal weight women delivered infants at a younger gestational age and of lower birth weight and length ; | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
9,
15
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
142,
154
]
} |
transient global amnesia is a benign condition in which an isolated episode of amnesia occurs and then clears completely . | NA | {
"id": "C0338591",
"name": "transient global amnesia",
"pos": [
0,
24
]
} | {
"id": "C0002622",
"name": "amnesia",
"pos": [
79,
86
]
} |
excessive rat in the right subdiaphragmatic region may simulate pathological processes such as subdiaphragmatic abscess , subpulmonic pleural effusion , ascites , tumor , and pneumoperitoneum . | NA | {
"id": "C0030660",
"name": "pathological",
"pos": [
64,
76
]
} | {
"id": "C0003962",
"name": "ascites",
"pos": [
153,
160
]
} |
this established a molecular basis for a phosphorylcreatine-creatine shuttle for energy transport in heart and skeletal muscle and provided an explanation for the inability to demonstrate experimentally a direct relation between muscle activity and the concentrations of adenosine triphosphate and adenosine diphosphate . | NA | {
"id": "C0031634",
"name": "phosphorylcreatine",
"pos": [
41,
59
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
60,
68
]
} |
the delayed catabolism of apolipoprotein e in type iii hlp patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
95,
100
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
105,
116
]
} |
a sensitive radioimmunoassay was devised with this antiserum , in which as little as 0.5 nanogram of mopeg can be accurately measured with a final antibody dilution of 1:180 . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
51,
60
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
147,
155
]
} |
the antibody appears to be specific for mopeg , since tritiated mopeg was not displaced from the antibodies by norepinephrine , epinephrine , dopamine , serotonin , or their major metabolites including mopeg-sulfate ( 333 nanograms each ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
111,
125
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
128,
139
]
} |
the exception to this rule might be the rare child with frank pyuria and/or urinary tract infection in whom the diagnosis of epididymo-orchitis is suggested by all parameters . | NA | {
"id": "C0034359",
"name": "pyuria",
"pos": [
62,
68
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
76,
99
]
} |
the adenovirus type 5 dna transformed cells of the same primary culture of rat embryo fibroblasts produced no tumors in syngeneic newborn rats . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} |
the possibility of a relationship between the thyroid hormone level and the peripheral action of catecholamines was examined in 4 normal-weight and 19 obese euthyroid subjects as well as in 27 hyperthyroid subjects by comparing the serum thyroid hormone level and the in vitro effect of catecholamines on lipolysis and cyclic amp accumulation in adipose tissue incubated with and without isopropyl noradrenaline ( isna ) or noradrenaline ( na ) . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
97,
111
]
} | {
"id": "C0022245",
"name": "isopropyl",
"pos": [
388,
397
]
} |
in all 25 patients wall motion abnormalities ranging from hypokinesia to frank dyskinesia were present at the site of the thrombus . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
58,
69
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
79,
89
]
} |
of the 13 patients who had lymphoproliferative disorders , eight had chronic lymphocytic leukemia , three had macroglobulinemia , and two had non-hodgkin 's lymphoma . | NA | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
27,
56
]
} | {
"id": "C0024419",
"name": "macroglobulinemia",
"pos": [
110,
127
]
} |
minimum inhibitory concentrations were measured for 650 p. aeruginosa clinical isolates and for repeated tests with p. aeruginosa atcc 27853 versus gentamicin , tobramycin , amikacin , netilmicin , sisomicin , carbenicillin , and ticarcillin , using the macro-broth , micro-broth , and agar dilution methods . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
148,
158
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
198,
207
]
} |
minimum inhibitory concentrations were measured for 650 p. aeruginosa clinical isolates and for repeated tests with p. aeruginosa atcc 27853 versus gentamicin , tobramycin , amikacin , netilmicin , sisomicin , carbenicillin , and ticarcillin , using the macro-broth , micro-broth , and agar dilution methods . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
185,
195
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
198,
207
]
} |
recent evidence indicates that hyperglycemia in diabetic patients , but not in normal subjects , is characterized by elevations of circulating levels of arginine vasopressin ( avp ; antidiuretic hormone , adh ) . | NA | {
"id": "C0003779",
"name": "arginine vasopressin",
"pos": [
153,
173
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
182,
202
]
} |
it is noted that mapping of tumor tissues by means of the two-dimensional analysis described by o'farrell and associates of 35s-methionine-labeled proteins can provide a characteristic map for each tumor and that the methionine-containing proteins of tumor cells can be independently modulated by the in vitro additions of estradiol and progesterone . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
147,
155
]
} | {
"id": "C0027642",
"name": "proteins",
"pos": [
239,
247
]
} |
according to these results , we conjectured that estrogen differentiates and proliferates cells with the features of fibroblast-like cells from the subcoelomic totipotential mesenchyme , and these cells are differentiated into smooth muscle-like cells and decidua-like cells under the influence of both estrogen and progesterone , resulting in the production of multiple subperitoneal nodules . | NA | {
"id": "C0016030",
"name": "cells",
"pos": [
90,
95
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
269,
274
]
} |
either type of experimental edema markedly enhanced the conversions of tritiated deoxycorticosterone and corticosterone to aldosterone and 18-hydroxycorticosterone by incubated capsular portions of the adrenal glands and partially normalized the deranged pattern of endogenous corticosteroid output in response to serotonin . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
86,
100
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
139,
163
]
} |
analysis of the kinetic data suggests that the autoregulatory effect of excess iodide results in a decline in the sodium dependency of iodide transport . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
79,
85
]
} | {
"id": "C0037521",
"name": "sodium",
"pos": [
114,
120
]
} |
fat depot cellularity was assessed in overfed dietary obesity resistant s 5b/pl ( s ) and susceptible osborne-mendel ( om ) rats . | NA | {
"id": "C1257763",
"name": "overfed",
"pos": [
38,
45
]
} | {
"id": "C0028754",
"name": "obesity",
"pos": [
54,
61
]
} |
desdipeptide proinsulin was only 10 % as potent as native insulin in stimulating [ 3h ] leucine incorporation , whereas proinsulin and desoctapeptide insulin were only 1 % as potent . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
16,
23
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
120,
130
]
} |
adenylyl cyclase activity was also stimulated by isoproterenol , norepinephrine , and epinephrine , but not by methoxamine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} |
the results suggest that 1 ) bilateral injections may be more appropriate for comparing the preoptic region with other putative angiotensin receptive sites , 2 ) there is a greater responsiveness of the preoptic region to bilateral as compared with unilateral injections , and 3 ) the aii receptive area is diffusely represented in the region of the medial preoptic nucleus . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
128,
139
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
285,
288
]
} |
chronic decerebrate rats fitted with oral fistulas for remote injection of water or nutrient were tested for their capacity to behaviorally compensate for dehydration by increasing their ingestion of water . | NA | {
"id": "C1163679",
"name": "for",
"pos": [
51,
54
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
200,
205
]
} |
two clinicopharmacologic properties of laam caused some patients to ask for a switch to methadone . | NA | {
"id": "C0025607",
"name": "laam",
"pos": [
39,
43
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
88,
97
]
} |
plasma and brain amino acids were deranged in a fashion similar to the derangements seen in portasystemic encephalopathy , with a decrease in plasma branched chain amino acids and an increase in most neutral amino acids in brain . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
17,
28
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
149,
175
]
} |
plasma and brain amino acids were deranged in a fashion similar to the derangements seen in portasystemic encephalopathy , with a decrease in plasma branched chain amino acids and an increase in most neutral amino acids in brain . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
17,
28
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
200,
219
]
} |
to define the mechanisms for transport of secretory iga ( siga ) into bronchial secretions , iga and secretory component in human bronchial mucosa were localized by immunoelectron microscopy . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
42,
55
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
101,
120
]
} |
a patient had a cutaneous t-cell lymphoma , appearing clinically as sezary syndrome , that developed two years after successful treatment of hodgkin 's disease with combined radiotherapy and chemotherapy . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphoma",
"pos": [
16,
41
]
} | {
"id": "C0036920",
"name": "sezary",
"pos": [
68,
74
]
} |
fifteen consecutive patients with this injury , 13 injuries from gunshot wounds and two injuries from blunt trauma , have been treated . | NA | {
"id": "C0043253",
"name": "injuries",
"pos": [
51,
59
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
108,
114
]
} |
glycogen , glucose , lactate , pyruvate , atp , adp , amp , phosphocreatine ( pcr ) and creatine ( cr ) contents of the muscle and lactate and pyruvate concentrations in iliac venous and radial arterial blood were determined using enzymatic fluorometric techniques . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
60,
75
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
88,
96
]
} |
energy charge ( ec ) , the adenylate ( atp + adp + amp ) and creatine ( pcr + cr ) pools were , however , unchanged . | NA | {
"id": "C0031634",
"name": "pcr",
"pos": [
72,
75
]
} | {
"id": "C0010286",
"name": "cr",
"pos": [
78,
80
]
} |
in spite of a restored blood flow to the legs , a severe metabolic derangement of the muscle was observed after declamping , with lowered ec , atp + adp + amp and pcr + cr indicating cellular damage . | NA | {
"id": "C0031634",
"name": "pcr",
"pos": [
163,
166
]
} | {
"id": "C0010286",
"name": "cr",
"pos": [
169,
171
]
} |
before , during and after the clamping period the central hemodynamics were monitored , and glycogen , glucose , lactate , pyruvate , phosphocreatine ( pcr ) , creatine ( cr ) , atp , adp and amp content in the thigh muscle were analyzed using enzymatic fluorometric techniques . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
134,
149
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
160,
168
]
} |
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