text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it could be demonstrated that the immobilizing and reagin activities of syphilis sera are due to separate antibodies . | NA | {
"id": "C0034761",
"name": "reagin",
"pos": [
51,
57
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
106,
116
]
} |
the data agree with results previously reported for normal alcohols and several series of glycols in showing a logarithmic increase in stimulating effect with increasing chain length . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
59,
67
]
} | {
"id": "C0017951",
"name": "glycols",
"pos": [
90,
97
]
} |
a note on the stability of thiamine hydrochloride in aqueous solution in the presence of iodine and potassium iodide . | NA | {
"id": "C0021966",
"name": "iodine",
"pos": [
89,
95
]
} | {
"id": "C0032831",
"name": "potassium iodide",
"pos": [
100,
116
]
} |
extreme open-bite malocclusion resulting from improper care of a complete horizontal fracture of the maxilla and a bilateral fracture of the mandible . | NA | {
"id": "C0266061",
"name": "open-bite",
"pos": [
8,
17
]
} | {
"id": "C0024636",
"name": "malocclusion",
"pos": [
18,
30
]
} |
difficult operative procedures are associated with a high incidence of birth trauma , asphyxia and death . | NA | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
86,
94
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
99,
104
]
} |
renal clearances of sodium penicillin g , procaine penicillin g , and inulin in infants and children . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
27,
39
]
} | {
"id": "C0030830",
"name": "procaine penicillin g",
"pos": [
42,
63
]
} |
a case of kaposi 's varicelliform eruption ( systemic herpes simplex ) with dendritic ulceration of the cornea . | NA | {
"id": "C0022504",
"name": "kaposi 's varicelliform eruption",
"pos": [
10,
42
]
} | {
"id": "C0019348",
"name": "herpes simplex",
"pos": [
54,
68
]
} |
high-resolution transmission electron microscopy , shows that carbon in the allende carbonaceous chondrite meteorite is predominantly a poorly crystalline graphite . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
62,
68
]
} | {
"id": "C0302933",
"name": "graphite",
"pos": [
155,
163
]
} |
adrenal epinephrine ( epi ) and norepinephrine ( ne ) as well as ca-synthesizing and degrading enzymes were not significantly changed in the animals after flight on cosmos 782 . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
8,
19
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
32,
46
]
} |
using the affinity chromatography technique in poly ( u ) sepharose it was found that the relative concentrations of rna types were in general drastically modified : mrna and rrna decreased ( from 2.6 +or- 0.31 to 1.28 +or- 0.15 and from 65.5 +or- 8.0 to 54.8 +or- 6.7 mcg/mg of protein respectively ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
117,
120
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
175,
179
]
} |
teflon and polyester , two polymers that have proven unsuccessful in prior clinical use , had wear rates 1,600 and 830 times greater than polyethylene , respectively , an indication that the laboratory wear test provided a quantitative prediction of the behavior of the materials in vivo . | NA | {
"id": "C0032474",
"name": "polyester",
"pos": [
11,
20
]
} | {
"id": "C0032521",
"name": "polymers",
"pos": [
27,
35
]
} |
surface enrichment of the proteins , calculated as the ratio of the surface and bulk fraction of each protein , also varied with copolymer composition , and indicated substantial differences in the composition of the surface and bulk phases . | NA | {
"id": "C0025252",
"name": "surface",
"pos": [
0,
7
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
102,
109
]
} |
this finding suggests that a significant portion of the differences between younger and older children and adult performance is due to the processing deficit of poor encoding strategies used by children . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
88,
102
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
194,
202
]
} |
we have found that cultured fibroblasts from patients with cystic fibrosis ( cf ) accumulate less 22na in the presence of ouabain than do normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
28,
39
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
138,
150
]
} |
after equilibration with 22na in ouabain-exposed cells to that in unexposed cells , after five hours of incubation , was 2.34 +/- 0.14 ( mean +/- s.d . ) in 13 fibroblast strains from normal subjects and 1.33 +/- 0.08 in eight strains from patients with cf . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
160,
170
]
} |
after hypoxemia , reactive hyperemia associated with a significant increase in urinary prostaglandin excretion ( pge and pgf2 alpha ) was observed in near-term fetuses but not in young fetuses . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
87,
100
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
113,
116
]
} |
a similarly affected female with left anterior hemiblock developed complete atrioventricular block at age 26 years , despite the ultrastructural changes , clinically detectable myocardial disease is not a feature of kearns-sayre syndrome . | NA | {
"id": "C0878544",
"name": "myocardial disease",
"pos": [
177,
195
]
} | {
"id": "C0022541",
"name": "kearns-sayre syndrome",
"pos": [
216,
237
]
} |
antibody production to brucella abortus antigen , a thymus-independent antigen was measured in an agglutination test . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
40,
47
]
} | {
"id": "C0003340",
"name": "thymus-independent antigen",
"pos": [
52,
78
]
} |
this phosphorus distribution , obtained with an imaging electron spectrometer in a conventional transmission electron microscope , simultaneously establishes new limits of sensitivity for elemental microanalysis . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
5,
15
]
} | {
"id": "C0013879",
"name": "elemental",
"pos": [
188,
197
]
} |
adult rats fed high concentrations of dietary protein for 9 weeks gained more weight than rats fed isoenergetic diets containing less protein . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
38,
53
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
134,
141
]
} |
the fatty acid compositions of serum phospholipids , cholesteryl esters , triglycerides , and free fatty acids were determined on a group of cystic fibrosis patients . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
94,
110
]
} |
the effects of ingesting the aromatic amino acid l-tyrosine on excretion of unconjugated catecholamines ( dopamine , norepinephrine , and epinephrine ) and tyrosine were studied . | NA | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
29,
48
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
156,
164
]
} |
the effects of ingesting the aromatic amino acid l-tyrosine on excretion of unconjugated catecholamines ( dopamine , norepinephrine , and epinephrine ) and tyrosine were studied . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
117,
131
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
138,
149
]
} |
documentation of arrhythmia in symptomatic patients with preexcitation syndromes may be difficult despite extended ambulatory monitoring ( mon ) . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
17,
27
]
} | {
"id": "C0032915",
"name": "preexcitation syndromes",
"pos": [
57,
80
]
} |
we conclude that the use of both monitoring and exercise testing will enhance detection of arrhythmia in patients with symptomatic preexcitation . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
91,
101
]
} | {
"id": "C0032915",
"name": "preexcitation",
"pos": [
131,
144
]
} |
this relationship was not evident in females , psr being observed in patients with lower hb and higher hbf levels than in the male group . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
89,
91
]
} | {
"id": "C0015936",
"name": "hbf",
"pos": [
103,
106
]
} |
owing to immunization by multiple blood and platelet transfusions , serum samples of most patients studied contained hla antibodies and platelet-specific alloantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
121,
131
]
} | {
"id": "C0022144",
"name": "alloantibodies",
"pos": [
154,
168
]
} |
studies on the inhibition of ellagic acid-activated hageman factor ( factor xii ) and hageman factor fragments . | NA | {
"id": "C0015527",
"name": "activated hageman factor",
"pos": [
42,
66
]
} | {
"id": "C0015525",
"name": "hageman factor",
"pos": [
86,
100
]
} |
the purity of the hb f is not essential and admixture of up to 70 % adult hb does not interfere with the determination . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
18,
22
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
74,
76
]
} |
a single precursor cell can give rise to mature cells with metabolic characteristic of either alveolar or tissue macrophages . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
9,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
48,
53
]
} |
in the current study , the levels of cortisol , progesterone , testosterone , dihydrotestosterone , androsterone , androsterone sulfate , dehydroisoandrosterone , dehydroisoandrosterone sulfate , estradiol , estrone , estradiol sulfate , and estrone sulfate were measured . | NA | {
"id": "C0011185",
"name": "dehydroisoandrosterone",
"pos": [
138,
160
]
} | {
"id": "C0057277",
"name": "dehydroisoandrosterone sulfate",
"pos": [
163,
193
]
} |
the nogalamycin analogs nogalamycin , dis-nogamycin , 7-con-o-methylnogalarol , and 7-con-omen were selected for further study because of their greater lethality in vitro and antitumor activity in vivo . | NA | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
4,
15
]
} | {
"id": "C0127527",
"name": "7",
"pos": [
84,
85
]
} |
under these conditions , the order of lethality after long-term exposure ( 8 hr to 24 hr ) was nogalamycin > dis-nogamycin > 7-con-omen , adriamycin > 7-con-o-methylnogalarol . | NA | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
95,
106
]
} | {
"id": "C0127527",
"name": "7",
"pos": [
151,
152
]
} |
in both cases , embryonal hemoglobins [ portland , gower 1 , hb x , and fetal hemoglobin ( hb-f ) ] were detected . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
26,
37
]
} | {
"id": "C0015936",
"name": "hb-f",
"pos": [
91,
95
]
} |
androgen-responsive cells are fibroblastic in appearance , have a low serum requirement , and can proliferate in suspension culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
20,
25
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
30,
42
]
} |
more than 60 % of total glycosaminoglycans from normal human liver and about 30 % from cancerous liver tissue were found to be heparan sulfate from their resistance to exhaustive digestion with chondroitinase abc and their susceptibility to nitrous acid treatment . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
24,
42
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
127,
142
]
} |
early effects of the tumor-promoting phorbol ester 12-o-tetradecanoylphorbol-13-acetate on the cell cycle traverse of asynchronous hela cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
37,
50
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
51,
87
]
} |
the measurement of thymidine incorporation rates into dna , of labeling and mitotic indices , and of flow cytometry revealed ( a ) an inhibition of cells in g1 shortly prior to their entering s phase , ( b ) a reduced rate of dna synthesis and a delayed passage of cells through s phase which were in this phase on addition of tpa , ( c ) a delayed passage through g2 of a portion of cells which were somewhere in the first half of the s phase on addition of tpa , and ( d ) an instant but short-lasting blockage in g2 immediately before mitosis . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
54,
57
]
} | {
"id": "C0919262",
"name": "b",
"pos": [
531,
532
]
} |
responses of synchronized hela cells to the tumor-promoting phorbol ester 12-o-tetradecanoylphorbol-13-acetate as evaluated by flow cytometry . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
60,
73
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
74,
110
]
} |
two aminoanthraquinone analogs 1,4-bis ( 2- [ ( 2-hydroxyethyl ) amino ] ethylamino ) -9,10-anthracenedione ( haq ) and 1,4-dihydroxy-5,8-bis ( 2- [ ( 2-hydroxyethyl ) amino ] ethylamino ] -9,10-anthracenedione ( dhaq ) have been shown to possess similar therapeutic activities against experimental tumors but different toxicities to the animals . | NA | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
92,
107
]
} | {
"id": "C0026259",
"name": "dhaq",
"pos": [
213,
217
]
} |
comparison of the efficiency of macrophage activation by maf encapsulated in liposomes of differing internal volume revealed that large multilamellar and large unioligolamellar liposomes were more efficient in activating peritoneal exudate macrophages than were small unilamellar liposomes . | NA | {
"id": "C0023828",
"name": "liposomes",
"pos": [
77,
86
]
} | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
268,
289
]
} |
amino acid analysis showed that protein 110/8.4 had an acidic : basic amino acid ratio of 1.25 and a high lysine and serine content ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
64,
80
]
} |
amino acid analysis showed that protein 110/8.4 had an acidic : basic amino acid ratio of 1.25 and a high lysine and serine content ; | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
64,
80
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
106,
112
]
} |
inhibition of terminal differentiation of hamster epidermal cells in culture by the phorbol ester 12-o-tetradecanoylphorbol-13-acetate . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
84,
97
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
98,
134
]
} |
low-grade tumors formed cysts spontaneously , and dibutyryl cyclic adenosine 3':5'-monophosphate stimulated both the number and the size of cysts . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
10,
16
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
140,
145
]
} |
grade iii tumors did not form any cysts in culture , and , with light microscopy , dibutyryl cyclic adenosine 3':5'-monophosphate had no visible effect on the fragments . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
10,
16
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
34,
39
]
} |
the inactivation with ara-a was less pronounced in the presence of adenosine , s-adenosylhomocysteine , adenine , adenosine 5'-monophosphate , or adenosine 5'-diphosphate , showed first-order kinetics , saturability , and irreversibility . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
67,
76
]
} | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
146,
157
]
} |
the results obtained by immunodiffusion analyses of antigenic determinants indicate that cea and nfa-2 can be divided into four antigenic moieties : the first one is distinctive for cea ( cancer determinant ) or nfa-2 ( nfa-2-distinctive determinant ) ; | NA | {
"id": "C0003320",
"name": "nfa-2",
"pos": [
97,
102
]
} | {
"id": "C0003316",
"name": "nfa-2",
"pos": [
220,
225
]
} |
female nmri mice were given injections of different doses of 17 beta-estradiol , 17 alpha-estradiol , diethylstilbestrol ( des ) , dienestrol , trans-stilbene , progesterone , testosterone , 5 alpha-dihydrotestosterone , or olive oil for the first 5 days after birth . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
102,
120
]
} | {
"id": "C0038333",
"name": "stilbene",
"pos": [
150,
158
]
} |
dna-rna hybridization studies , using nuclear rna 's ( nrna 's ) labeled in vivo and in vitro with high specific radioactivities , were performed to compare the nrna populations of normal rat liver , livers treated with 3'-methyl-4-dimethylaminoazobenzene ( 3'-me-dab ) , and 3'-me-dab-induced hepatomas . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
4,
7
]
} | {
"id": "C0035700",
"name": "nuclear rna 's",
"pos": [
38,
52
]
} |
in 19 patients with unstable angina pectoris at rest , plasma levels of the platelet-derived proteins beta-thromboglobulin and platelet factor 4 were significantly elevated in blood samples obtained during or within 4 hours after episodes of angina , but were usually normal during quiescent intervals . | NA | {
"id": "C0002965",
"name": "unstable angina pectoris",
"pos": [
20,
44
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
242,
248
]
} |
each patient was suspected clinically of having hypertrophic cardiomyopathy because of a distinctly abnormal ecg and either a family history of hypertrophic cardiomyopathy or cardiac symptoms . | NA | {
"id": "C0007194",
"name": "hypertrophic cardiomyopathy",
"pos": [
48,
75
]
} | {
"id": "C0949658",
"name": "family",
"pos": [
126,
132
]
} |
this enzyme-radioimmunoassay for the measurement of l-dopa , dopamine , and 3-o-methyldopamine is based on the incubation of urine in the presence of catechol-o-methyltransferase , aromatic-l-amino-acid decarboxylase , and s-adenosylmethionine . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
61,
69
]
} | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
80,
94
]
} |
to evaluate the role of l-dopa metabolism in melanoma , we used the enzyme-radioimmunoassay to assess concentrations of l-dopa , dopamine , and 3-o-methyldopamine in urine from 10 healthy subjects , 10 hospitalized patients without melanoma and 28 patients with different degrees of melanoma . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
129,
137
]
} | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
148,
162
]
} |
no significant difference in urinary l-dopa , dopamine , and 3-o-methyldopamine excretion rates was seen between normal subjects ( l-dopa 1.3 +/- 0.3 , dopamine 147 +/- 38 , and 3-o-methyldopamine 31.4 +/- 13.6 microgram/24 h ) , hospitalized patients without melanoma , and amelanotic melanoma patients . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
46,
54
]
} | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
182,
196
]
} |
however , the excretion rates for these metabolites in melanotic melanoma ( l-dopa 5.6 +/- 1.2 , dopamine 555 +/- 121 , and 3-o-methyldopamine 178 +/- 40.3 microgram/24 h ) were significantly ( p < 0.005 ) higher than in control or amelanotic melanoma subjects . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
97,
105
]
} | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
128,
142
]
} |
this effect could be eliminated by converting creatine , the product of the enzymic reaction , to creatine phosphate . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
46,
54
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
98,
116
]
} |
we saw no significant interferences by relatively high concentrations of acetone , acetylacetone , adp , creatine , creatine phosphate , glucose , glycocyamine , or pyruvate . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
105,
113
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
116,
134
]
} |
we suggest that insulin antibodies formed complexes with proinsulin-like material in the plasma of this patient , which accounted for most of the c-peptide immunoreactivity in her unextracted plasma . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
57,
67
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
146,
155
]
} |
production and release of thyrotropin and its subunits by monolayer cultures containing bovine anterior pituitary cells . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
26,
37
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
95,
113
]
} |
microinjections of epinephrine and norepinephrine into the vmh also caused rises in the levels of both glucagon and insulin , although the effects of norepinephrine were much less than those of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
35,
49
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
194,
205
]
} |
continuous infusion in saralasin , an angiotensin ii antagonist , prevented the reduction in sngfr and nephron plasma flow after benzolamide . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
23,
32
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
38,
52
]
} |
work on experimental desensitization as well as clinical studies in lymphoproliferative disorders and sarcoidosis suggest that such control can be both at the stage of lymphokine production and at the stage in which lymphokine activity is being expressed . | NA | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
68,
97
]
} | {
"id": "C0036202",
"name": "sarcoidosis",
"pos": [
102,
113
]
} |
we have shown that human immune interferon is a product of mitogen stimulated t lymphocyte subsets t mu , t gamma , and t phi , and have investigated some of interferon 's antiviral , antiproliferative , and antidifferentiational ( or antimaturational ) effects . | NA | {
"id": "C0021745",
"name": "immune interferon",
"pos": [
25,
42
]
} | {
"id": "C0021747",
"name": "interferon 's",
"pos": [
158,
171
]
} |
it is hypothesized that basic amino acids as well as glutamic acid and glutamine may have an important role in metabolic regulation of acid-base balance . | NA | {
"id": "C0301714",
"name": "basic amino",
"pos": [
24,
35
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
71,
80
]
} |
it is hypothesized that basic amino acids as well as glutamic acid and glutamine may have an important role in metabolic regulation of acid-base balance . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
53,
66
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
71,
80
]
} |
with the chloride salts the response varied in magnitude depending on the accompanying cation with the following order of decreasing response , rb+ , na+ , cs+ , nh4+ , k+ , choline+ , and li+ , cacl2 and mgcl2 did not elicit a feedback response . | NA | {
"id": "C0008203",
"name": "chloride salts",
"pos": [
9,
23
]
} | {
"id": "C0024472",
"name": "mgcl2",
"pos": [
205,
210
]
} |
although 24 patients had hepatomegaly , and the majority had abnormalities of serum transaminases , alkaline phosphatase , and bsp clearance , only 3 had evidence of portal hypertension and complications of advanced liver disease . | NA | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
166,
185
]
} | {
"id": "C0023895",
"name": "of",
"pos": [
204,
206
]
} |
with control cells labeled protein and specifically albumin appeared in the medium 20 min from the start of the pulse and this release of protein was not inhibited by 50 mm or 100 mm ethanol incubated with cells from the same animal whether the donor has been fed or fasted . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
52,
59
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
138,
145
]
} |
inflammatory bowel disease , except for severe active crohn 's disease , does not seem to affect the outcome of concurrent pregnancy adversely . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
0,
26
]
} | {
"id": "C0010346",
"name": "crohn 's",
"pos": [
54,
62
]
} |
she demonstrated hepatomegaly with marked elevations of serum transaminases , alkaline phosphatase , and bile acids without clinical jaundice or hyperbilirubinemia . | NA | {
"id": "C0022346",
"name": "jaundice",
"pos": [
133,
141
]
} | {
"id": "C0020433",
"name": "hyperbilirubinemia",
"pos": [
145,
163
]
} |
to test the hypothesis that hepatic cholesterol synthesis and concentration are specifically increased in women and men with cholesterol gallstone disease , we studied in a series of 24 surgical liver biopsy specimens , the rate of acetate incorporation into cholesterol and co2 , and the concentration of free and esterified cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
36,
47
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
315,
337
]
} |
chemiluminescence response upon phagocytosis was found to be enhanced in circulating blood monocytes derived from patients with active sarcoidosis , suggesting that these monocytes are activated and easily generate reactive species of oxygen including singlet oxygen . | NA | {
"id": "C0162772",
"name": "reactive",
"pos": [
215,
223
]
} | {
"id": "C0074565",
"name": "singlet oxygen",
"pos": [
252,
266
]
} |
it appears that , for a series of tolerogenic conjugates of the same antigen , there exists some inverse relationship between the degree of substitution and the molecular weight of mpeg , i.e . a high level of tolerogenicity with a concomitant reduction or total loss of allergenicity was achieved with a lower degree of substitution utilizing mpegs of increasing molecular weights . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
69,
76
]
} | {
"id": "C0002092",
"name": "allergenicity",
"pos": [
271,
284
]
} |
in the presence of nadph , the apparent km was 2.6 microm for thymine and 1.8 microm for uracil . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
62,
69
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
89,
95
]
} |
apparent km for nadph was 15 microm with thymine as substrate and 11 microm with uracil . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
41,
48
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
81,
87
]
} |
factor vii protein obtained by this method has only 1.3 to 1.5 times more activity in a one-stage clotting assay than in a coupled amidolytic assay ( seligsohn , u. , osterud , b. , and rapaport , s. i . ( 1978 ) blood 52 , 978-988 ) , which is taken to mean than it contains less than 5 % of activated factor vii . | NA | {
"id": "C0015502",
"name": "factor vii",
"pos": [
0,
10
]
} | {
"id": "C0015505",
"name": "activated factor vii",
"pos": [
293,
313
]
} |
it has alanine as an nh2-terminal amino acid residue and contains 8.8 gama-carboxyglutamic acid residues/mol of protein . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
7,
14
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
34,
39
]
} |
the purified lectin , which behaved as a large aggregate , could be dissociated into two proteins with apparent molecular weights of 13,000 and 16,000 upon electrophoresis in sodium dodecyl sulfate . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
13,
19
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
89,
97
]
} |
125i-tryptic peptide maps of these proteins showed that they were distinct from each other and also from lectins of similar molecular weight previously purified from chicken . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
35,
43
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
105,
112
]
} |
human chylomicrons were isolated from plasma from a subject with familial hypertriglyceridemia and converted to chylomicron remnants by incubation with postheparin plasma . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
6,
18
]
} | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
112,
132
]
} |
remnant particles produced after hydrolysis of 70 to 80 % of chylomicron triglyceride increased cell cholesterol content to an amount nearly identical to that observed with ldl when the two lipoproteins were incubated at an equal cholesterol concentration . | NA | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
61,
72
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
190,
202
]
} |
the antiserum against calf thymus dna polymerase-beta cross-reacts with all vertebrate dna polymerase-beta preparations tested , but does not cross-react with trypanosome dna polymerase-beta , dna polymerase-gamma , terminal transferase , yeast dna polymerases , and escherichia coli dna polymerase i . | NA | {
"id": "C0525039",
"name": "dna",
"pos": [
34,
37
]
} | {
"id": "C0012892",
"name": "dna",
"pos": [
284,
287
]
} |
the antibodies against calf thymus dna polymerase-alpha cross-react with dna polymerase-alpha from mouse , human , and chicken , but do not cross-react with dna polymerase-alpha from sea urchin embryos and drosophila embryos , dna polymerase-beta , dna polymerase-gamma , terminal transferase , yeast dna polymerases , and e. coli dna polymerase i . | NA | {
"id": "C0525039",
"name": "dna polymerase-beta",
"pos": [
227,
246
]
} | {
"id": "C0012892",
"name": "dna polymerases",
"pos": [
301,
316
]
} |
detailed restriction enzyme maps have been determined for the three major rat casein and the fourth principal milk protein , alpha-lactalbumin , cdna clones . | NA | {
"id": "C0007332",
"name": "casein",
"pos": [
78,
84
]
} | {
"id": "C0026138",
"name": "milk protein",
"pos": [
110,
122
]
} |
the increase in glycosphingolipid content of both cells and reisolated hdl3 particles was hdl3 concentration-dependent up to a concentration of 1 mg/ml and appeared to be the result of a stimulation of cellular glycolipid synthesis by hdl3 and subsequent transfer to hdl3 in the medium . | NA | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
16,
33
]
} | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
211,
221
]
} |
cells grown from human articular cartilage by an explant method were shown to be dedifferentiated chondrocytes by the failure to respond to treatment with 5-bromodeoxyuridine , vitamin a , or the addition of hyaluronic acid . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
98,
110
]
} |
no specific interactions between nh2-terminal fragments encompassing residues 1-189 with troponin , troponin-t , or cb1 immobilized on a sephadex 4b column could be demonstrated . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
89,
97
]
} | {
"id": "C0077404",
"name": "troponin-t",
"pos": [
100,
110
]
} |
meister and co-workers ( manning , j. m. , moore , s. , rowe , w. b. , and meister , a . ( 1969 ) biochemistry 8 , 2681-2685 ) have shown that l-methionine-s-sulfoximine , one of the four diastereomers of methionine sulfoximine , preferentially inhibits glutamine synthetase irreversibly in the presence of atp , due to the formation of tightly bound products , adp , and methionine sulfoximine phosphate . | NA | {
"id": "C0025646",
"name": "l-methionine",
"pos": [
143,
155
]
} | {
"id": "C0025649",
"name": "methionine sulfoximine",
"pos": [
372,
394
]
} |
the other protein antigens were reduced or modified on many cells other than the fibroblast , indicating that the expression of these antigenic determinants was differentiation specific . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
81,
91
]
} |
at saturating levels of factor va ( 1.2 x 10 ( -8 ) m ) , 2300 molecules of factor xa are bound to the platelet , whereas at an equivalent concentration of unactivated factor v , only 800 molecules of factor xa are bound . | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
24,
33
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
168,
176
]
} |
monovalent fab fragments of burro antibovine factor v inhibit , to the same degree , the rate of thrombin generation and the binding of factor va and factor xa to the platelet surface . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
45,
53
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
136,
145
]
} |
the composition of lactosylceramide , trihexosylceramide , globoside , and hematoside was related to ceramide b and they contained about 60 % erythrosphingosine ( 18:1 ) , 25 % threosphingosine ( 18:1 ) , and 10 % dihydrosphingosine ( 18:0 ) . | NA | {
"id": "C0017647",
"name": "globoside",
"pos": [
59,
68
]
} | {
"id": "C0007745",
"name": "ceramide",
"pos": [
101,
109
]
} |
the reaction of enzyme containing 1 pyridoxal-5-p/dimer with the inhibitors nabh4 and dl-gabaculine was studied by observing changes in the absorption spectrum of the bound coenzyme and by monitoring loss of catalytic activity . | NA | {
"id": "C0034266",
"name": "pyridoxal",
"pos": [
36,
45
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
173,
181
]
} |
our results provide direct experimental evidence for a previously proposed model in which a short terminal redundancy in viral rna , and a dna copy of the redundant sequence , are used to allow the growing dna chain to move from the 5 ' to the 3 ' end of the template . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
137,
142
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
206,
209
]
} |
in buffer conditions of 0.1 m tris-hcl , 0.1 m nacl , 1 mm edta , ph 7.4 , we estimate 1.8 mol of cl- bound upon dissociation of 1 mol of oxy tetramers into oxy dimers , whereas the deoxy molecules dissociate without any change in bound chloride . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
47,
51
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
237,
245
]
} |
the granulosa cells obtained from hypophysectomized , estrogen-treated rats were treated with various hormones in vitro and 20 alpha-hydroxysteroid dehydrogenase activity determined by measuring the conversion of radiolabeled 20 alpha-hydroxy-pregn-4-en-3-one to progesterone . | NA | {
"id": "C0012311",
"name": "20",
"pos": [
124,
126
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
263,
275
]
} |
although the high affinity atpase resembled the erythrocyte ca2+-pumping atpase in the properties mentioned above , it differed in that it failed to respond to mg2+ or calmodulin . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
27,
33
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
60,
63
]
} |
this enzyme , the erythrocyte enzyme , and the adipocyte plasma membrane ca2+ atpase all belong to the class of ca2+ atpases with plasma membrane distribution and high affinity for ca2+ , indicating that they are ca2+ extrusion pumps . | NA | {
"id": "C0300252",
"name": "plasma membrane ca2",
"pos": [
57,
76
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
213,
216
]
} |
the enzymes studied were the normal isozymes , ca i and ca ii , a secondary isozyme of ca i , designated ca i ( +1 ) , the ca i variants ca i london ( 102 glu leads to lys ) , ca i michigan-2 ( 100 thr leads to lys ) , and the ca ii variant ca ii2 ( 251 asn leads to asp ) . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
4,
11
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
76,
83
]
} |
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