text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
four monoclonal antibodies were chosen that demonstrated reactivities with human small cell carcinoma of the lung and not with apparently normal diploid fibroblasts or lymphoblastoid cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
153,
164
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
183,
188
]
} |
alpha-1-acid glycoprotein is an acute-phase serum protein which is found in increased amounts in patients with a variety of cancers . | NA | {
"id": "C0029297",
"name": "alpha-1-acid glycoprotein",
"pos": [
0,
25
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
32,
43
]
} |
the mean percentage of recovered beta-hexosaminidase activity associated with peaks of beta-hexosaminidase b ( i.e. , peaks with isoelectric point values at or near that of normal beta-hexosaminidase b ) was slightly elevated in cancer sera [ 37 +/- 9.6 % ( s.d . ) ] when compared to normal ( 32 +/- 9 % ) and pathological control ( 29 +/- 10 % ) sera . | NA | {
"id": "C0019481",
"name": "beta-hexosaminidase b",
"pos": [
87,
108
]
} | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
180,
199
]
} |
the suitability of the reductive-cleavage method for analysis of the linkage positions in d-fructofuranosyl residues of d-fructans was examined by using sucrose , chicory-root inulin , and aerobacter levanicum levan as models . | NA | {
"id": "C0016743",
"name": "fructans",
"pos": [
122,
130
]
} | {
"id": "C0021936",
"name": "inulin",
"pos": [
176,
182
]
} |
human-salivary , porcine-pancreatic , and bacillus subtilis alpha amylases were used to study the structure of amylose-v complexes with butyl alcohol , tert-butyl alcohol , 1,1,2,2-tetrachloroethane , and 1-naphthol , and of retrograded amylose . | NA | {
"id": "C0001977",
"name": "butyl alcohol",
"pos": [
136,
149
]
} | {
"id": "C0076141",
"name": "tert-butyl alcohol",
"pos": [
152,
170
]
} |
gel filtration of human-salivary and porcine-pancreatic alpha amylase hydrolyzates gave resistant fragments whose peak fractions , i.e. , the three pooled fractions from the gel-filtration column with the highest amount of carbohydrate , had a d.p . of 75 +/- 4 for the amylose complex with butyl alcohol , 90 +/- 3 for those with tert-butyl alcohol and tetrachloroethane , and 123 +/- 2 for that with 1-naphthol . | NA | {
"id": "C0001977",
"name": "butyl alcohol",
"pos": [
291,
304
]
} | {
"id": "C0076141",
"name": "tert-butyl alcohol",
"pos": [
331,
349
]
} |
in this study , rabbit antisera produced to the ( gal ) n-ta-bsa were characterized by using an enzyme-linked , immunosorbent assay under conditions that allow only the antibodies directed to the carbohydrate part of the antigen to react with the solid-phase ( gal ) n-ta-bsa antigens . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
23,
31
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
169,
179
]
} |
inhibition assays using ( gal ) n-ta-bsa conjugates showed a relative specificity of the antisera for the number of gal residues on the ta bridging group to the bsa carrier-protein , indicating that antibodies having specificities to oligosaccharide branch points can be produced . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
89,
97
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
199,
209
]
} |
mapping of neurons in the central nervous system of the guinea pig by use of antisera specific to the molluscan neuropeptide fmrfamide . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
112,
124
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
125,
134
]
} |
immunoreactive neurons were mapped in the central nervous system of colchicine-treated and untreated guinea pigs with the use of two antisera to the molluscan neuropeptide fmrfamide . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
159,
171
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
172,
181
]
} |
the calcium activation curve for amylase release seemed to be independent of cyclic nucleotides , but was markedly increased in both the extent of release and apparent affinity for ca2+ in the presence of the phorbol ester 12-0-tetradecanoyl phorbol 13 acetate . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
209,
222
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
242,
249
]
} |
these studies demonstrate that polyoma-virus-encoded middle tumor antigen is associated with pp60c-src in lysates of polyoma-virus-infected and polyoma-virus-transformed cells and suggest a novel mechanism for the functional activation of a cellular proto-oncogene product , namely , that the interaction between middle tumor antigen and pp60c-src leads to a stimulation of pp60c-src tyrosyl kinase activity . | NA | {
"id": "C0033712",
"name": "cellular",
"pos": [
241,
249
]
} | {
"id": "C0080059",
"name": "pp60c-src",
"pos": [
374,
383
]
} |
clonal and 2d protein gel analyses demonstrate that 5-azacytidine converts 10t1/2 cells into three stably determined , but undifferentiated , stem cell lineages which can differentiate into myofibers , chondrocytes , and adipocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
82,
87
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
202,
214
]
} |
a clathrin-coated , golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
53,
60
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
88,
98
]
} |
when the intracellular transit of 3h-labeled ( pro ) -insulin polypeptides is perturbed by monensin in the pancreatic b-cell , proinsulin conversion is impaired and the radioactive peptides accumulate in a clathrin-coated membrane compartment related to the golgi apparatus . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
54,
61
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
127,
137
]
} |
both the unresponsiveness of t cells from infected mice and their immunosuppressive activity in vitro could be essentially ablated by supplementation of the tissue culture medium with a supernatant containing very high titers of the t-cell growth factor interleukin 2 ( il-2 ) . | NA | {
"id": "C0021758",
"name": "t-cell growth factor",
"pos": [
233,
253
]
} | {
"id": "C0021764",
"name": "interleukin",
"pos": [
254,
265
]
} |
removal of carbonyl iron ( cfe ) - , plastic- , or nylon-wool-adherent cells removed the suppressive action of juvenile spleen cells , but irradiation did not . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
37,
44
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
51,
56
]
} |
thin-layer chromatography of spleen cell extracts showed that pha-stimulated spleen cells from infected animals synthesized 54 and 27 % more 5-hydroxyeicosatetraenoic acid ( 5-hete ) and 12/15-hete respectively , when compared to spleen cells from noninfected mice . | NA | {
"id": "C0020349",
"name": "hydroxyeicosatetraenoic acid",
"pos": [
143,
171
]
} | {
"id": "C0044800",
"name": "12",
"pos": [
187,
189
]
} |
the inhibition of the response of eosinophils by ecif was selective for the t cell-derived chemotactic factor , which has been isolated from dnp-ascaris extract-induced skin lesions ( termed delayed ecf-a ) but not for another ecf ( termed delayed ecf-b ) , which was also isolated from the same skin lesions . | NA | {
"id": "C0008014",
"name": "ecif",
"pos": [
49,
53
]
} | {
"id": "C0008013",
"name": "chemotactic factor",
"pos": [
91,
109
]
} |
characterization of natural killer cells induced in the peritoneal exudates of mice infected with listeria monocytogenes : a study of their tumor target specificity and their expression of murine differentiation antigens and human nk-associated antigens . | NA | {
"id": "C0003324",
"name": "differentiation antigens",
"pos": [
196,
220
]
} | {
"id": "C0003339",
"name": "nk-associated antigens",
"pos": [
231,
253
]
} |
relevant proportions of okt6+ ( common thymocyte antigen ) and okt10+ ( thymocytes , activated t cells , precursor cells ) cells were found in cord blood as opposed to adult blood ( 10.8 +/- 8.6 % vs 0.6 +/- 0.6 % and 67 +/- 18.0 % vs 8 +/- 2.1 % , respectively ) , while terminal deoxynucleotidyl transferase-positive cells were observed only in two samples of cord blood . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
105,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
319,
324
]
} |
the sugar specificity of the receptors of rat thymocytes were studied using the sugar inhibition test with various monosaccharides and glycoproteins , exoglycosidases treatment on rat thymocytes , and adsorption of fetal calf serum with lectins and sugar gels . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
115,
130
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
249,
254
]
} |
when sulfoxides other than dimethyl sulfoxide were tested for their ability to protect 11 beta-hydroxylase in the presence of cortisol , several aryl sulfoxides , particularly dibenzyl sulfoxide , as well as dipropyl sulfoxide , were active at concentrations to 1/200 of that required for me2so . | NA | {
"id": "C0012403",
"name": "dimethyl sulfoxide",
"pos": [
27,
45
]
} | {
"id": "C0038771",
"name": "sulfoxides",
"pos": [
150,
160
]
} |
the tight association of the hydroperoxide product of oestrone with dna , which may proceed via hydrogen bonding between the -ooh group and oxygen atoms of the backbone phosphate groups or of the furanose ring , might be a cause of chemical modification of dna and of mutagenic effects . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
68,
71
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
271,
272
]
} |
[ quantitative determination of total alkaloids and aconitine in the root of aconitum carmichaeli and aconitum kusnezoffii ] . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
38,
47
]
} | {
"id": "C0001159",
"name": "aconitine",
"pos": [
52,
61
]
} |
comparison of dph and pnpc in dipalmitoyl-pc-liposomes with and without 50 mol % cholesterol , showed at temperatures above the phase transition of pure dipalmitoyl-pc the presence of cholesterol increased the rs-value for dph strongly , whereas the rs-value for pnpc was much less affected . | NA | {
"id": "C0000039",
"name": "dipalmitoyl-pc",
"pos": [
30,
44
]
} | {
"id": "C1959616",
"name": "pnpc",
"pos": [
263,
267
]
} |
33 of the 35 cases give a definite positive result and in the 15 control cases , with no parasitosis or an other helminthiasis , the test was negative . | NA | {
"id": "C0030499",
"name": "parasitosis",
"pos": [
89,
100
]
} | {
"id": "C0018889",
"name": "helminthiasis",
"pos": [
113,
126
]
} |
quiescent normal human fibroblasts were irradiated with u.v . and the ensuing chromatin events were visualized by inducing premature chromosome condensation in the treated cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
23,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
in dog bladder dna , n- ( deoxyguanosine-8-yl ) -2-acetylaminofluorene was the principal dna adduct ( 39.0-46.5 % of the total ) with smaller amounts ( 15.5-22.2 % of the total ) in the other species . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
15,
18
]
} | {
"id": "C0242958",
"name": "dna adduct",
"pos": [
89,
99
]
} |
neither the overall binding of aaf to bladder dna , nor the formation of specific aaf -- dna adducts is correlated with the relative susceptibilities of these five species to aromatic amine-induced urinary bladder carcinogenesis . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} | {
"id": "C0242958",
"name": "dna",
"pos": [
89,
92
]
} |
this approach involves selecting in tissue culture for cells which are expressing a drug-resistance marker co-transferred with the tumour dna thus isolating the small number of cells which have taken up and are expressing exogenously added dna . | NA | {
"id": "C0012930",
"name": "tumour dna",
"pos": [
131,
141
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
240,
243
]
} |
ethanol , equivalent to a man drinking 1 pint ( 0.5 l ) of beer , prevents this first pass clearance in the rat and exposes sensitive extrahepatic organs to this carcinogen . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
0,
7
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
59,
63
]
} |
despite similar dna binding characteristics ( determined by flow cytometry ) of ho33342 in normal and at transformed fibroblasts , the at cells show : ( i ) enhanced cell killing and increased accumulation of cells in g2 phase of the cell-cycle [ both biological responses being relatively resistant in at cells to modification by an inhibitor of poly ( adp ribosyl ) ation ] , ( ii ) no resistance of de novo dna synthesis to ho33342-induced inhibition , ( iii ) elevated levels of slow-rejoining ligand-induced dna strand-breaks , and ( iv ) enhanced expression of chromatin regions accessible to an exogenously supplied endonuclease . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
117,
128
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
306,
311
]
} |
the strong inhibition of dna adduct formation by retinoids ( retinol , retinal , retinoic acid and retinyl acetate ) , riboflavin , riboflavin 5'-phosphate , flavin adenine dinucleotide , cu2+ , 7,8-benzoflavone , disulfiram , butylated hydroxyanisole , butylated hydroxytoluene and phenothiazine suggests that these agents may have potential anticarcinogenic activity against aflatoxin b1 . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
119,
129
]
} | {
"id": "C0016388",
"name": "riboflavin 5",
"pos": [
132,
144
]
} |
we have found that u.v . irradiation of these cells results in the enhanced removal of both aflatoxin b1 ( afb1 ) and acetylaminofluorene ( aaf ) adducts from the alpha dna sequences without affecting repair in the bulk of the dna . | NA | {
"id": "C0242958",
"name": "adducts",
"pos": [
146,
153
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
227,
230
]
} |
overflow of adrenaline and dopamine occurs to a minor degree ( less than 5 % of the corresponding noradrenaline overflow ) , and only after ischemic periods of more than 15 minutes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
12,
22
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
98,
111
]
} |
these data suggest considerable species difference in responses to leukotriene d4 , a major component of the slow-reacting substance of anaphylaxis , in the pulmonary vascular bed . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
67,
81
]
} | {
"id": "C0038091",
"name": "of",
"pos": [
133,
135
]
} |
platelet activation was measured by radioimmunoassay of plasma platelet factor 4 ( pf4 ) , beta-thromboglobulin ( btg ) , and thromboxane b2 ( txb2 ) in blood samples withdrawn through catheters , and fibrin formation was assessed by determination of fibrinopeptide a ( fpa ) levels . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
201,
207
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
251,
267
]
} |
this study demonstrates that ( 1 ) collection of blood samples through cardiovascular catheters causes artifactual elevation of fpa , pf4 , btg , and txb2 levels , and ( 2 ) heparin-bonded catheter surfaces effectively prevent catheter-induced platelet alpha-granule release and fibrin formation on catheter surfaces . | NA | {
"id": "C0016022",
"name": "fpa",
"pos": [
128,
131
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
279,
285
]
} |
screening of the serum for avian precipitating antibody was negative but canary precipitins were present . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
47,
55
]
} | {
"id": "C0032936",
"name": "precipitins",
"pos": [
80,
91
]
} |
we observed no cross reactivity with methanol , isopropanol , or acetone , and analytical recovery of ethanol from serum averaged 101 % . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
37,
45
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
102,
109
]
} |
we observed no cross reactivity with methanol , isopropanol , or acetone , and analytical recovery of ethanol from serum averaged 101 % . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
48,
59
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
102,
109
]
} |
the assay system consisted of polystyrene balls with immobilized antibody f ( ab ' ) 2 fragments and the same antibody fab ' fragments labeled with beta-d-galactosidase from e. coli . | NA | {
"id": "C0021009",
"name": "antibody",
"pos": [
65,
73
]
} | {
"id": "C0021031",
"name": "antibody fab",
"pos": [
110,
122
]
} |
orally administered ( index patient ) uracil and thymine were excreted for the greater part whilst dihydrouracil and s-dihydrothymine were mainly metabolised . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
38,
44
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
126,
133
]
} |
we evaluated the effects of the pyrimidine ( cytidine and uridine ) tri- and diphosphate nucleotides ( ctp , cdp , utp , udp ) and the choline and ethanolamine derivatives of cdp ( cdp-choline , cdp-ethanolamine ) on the activities of key enzymes of the embden-meyerhof pathway . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
135,
142
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
181,
192
]
} |
five of a personal series of 47 patients with carcinoma of the middle and external ear had basal cell carcinoma . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
46,
55
]
} | {
"id": "C0007117",
"name": "basal cell carcinoma",
"pos": [
91,
111
]
} |
the effect of npt 15392 , 9- ( erythro-2-hydroxy-3-nonyl ) -6-hydroxypurine , on the phytohemagglutinin of okt3+ , okt4+ , okt8+ , and okm1+ cell-depleted and undepleted peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
141,
145
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
170,
204
]
} |
to test this possibility , 37 patients with ibd , 24 with crohn 's disease and 13 with ulcerative colitis who were not being treated with immunosuppressive therapy were studied . | NA | {
"id": "C0021390",
"name": "ibd",
"pos": [
44,
47
]
} | {
"id": "C0010346",
"name": "crohn 's",
"pos": [
58,
66
]
} |
peripheral blood mononuclear cells from patients with essential mixed cryoglobulinemia ( emc ) were studied for their ability to differentiate into cells containing cytoplasmic immunoglobulins ( ig ) and to synthetize ig after in vitro pokeweed mitogen activation . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
clearly , infertility is one of several gynecologic conditions that may have a profound effect on the psychological and sexual status of its victim . | NA | {
"id": "C0021359",
"name": "infertility",
"pos": [
10,
21
]
} | {
"id": "C0017411",
"name": "gynecologic conditions",
"pos": [
40,
62
]
} |
this is a survey of the pharmacokinetics and mechanisms of action , orthopedic use , antimicrobial activity , and adverse reactions to erythromycin , lincomycin and clindamycin , tetracycline , chloramphenicol , polymyxins , vancomycin , and fosfomycin . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
150,
160
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
165,
176
]
} |
according to reports since 1936 , this is the sixteenth case of cancer associated with complete situs inversus , the second ovarian cancer , the first embryonal carcinoma of the ovary , and the youngest cancer case to be reported in association with this congenital anomaly . | NA | {
"id": "C0037221",
"name": "situs inversus",
"pos": [
96,
110
]
} | {
"id": "C0000768",
"name": "congenital anomaly",
"pos": [
255,
273
]
} |
noninvasive assessment of cardiac function and pulmonary hypertension in persistent pulmonary hypertension of the newborn . | NA | {
"id": "C0020542",
"name": "pulmonary hypertension",
"pos": [
47,
69
]
} | {
"id": "C0031190",
"name": "pulmonary hypertension",
"pos": [
84,
106
]
} |
the acute interaction of zimelidine ( z ) with ethanol ( e ) was examined in six healthy men aged 20 to 37 yr who randomly received each of four treatments 1 wk apart : z , 200 mg by mouth , preceded by 1 hr and followed for 7 hr of oral e in juice dosed to maintain blood alcohol concentrations between 800 and 1000 mg/l ; | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
47,
54
]
} | {
"id": "C0684262",
"name": "blood alcohol concentrations",
"pos": [
267,
295
]
} |
each subject received a 10-mg iv dose of naltrexone hcl and a 63-mg dose by subcutaneous implantation of naltrexone beads . | NA | {
"id": "C0355800",
"name": "naltrexone hcl",
"pos": [
41,
55
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
105,
115
]
} |
studies on arterial mineralocorticoid and glucocorticoid receptors : evidence for the translocation of steroid-cytoplasmic receptor complexes to cell nuclei . | NA | {
"id": "C0034809",
"name": "glucocorticoid receptors",
"pos": [
42,
66
]
} | {
"id": "C0034840",
"name": "steroid",
"pos": [
103,
110
]
} |
the intestine secretes dietary fat in chylomicrons , lipoproteins that transport triglyceride to tissues for storage . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
38,
50
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
53,
65
]
} |
dietary cholesterol is transported to the liver by chylomicron remnants which are formed from chylomicrons . | NA | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
51,
71
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
94,
106
]
} |
no cross-reactivity could be demonstrated by immunoelectrophoresis with either porcine pancreatic elastase or human leukocyte elastase using monospecific antisera . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
87,
106
]
} | {
"id": "C0064833",
"name": "human leukocyte",
"pos": [
110,
125
]
} |
often they are first recognized after regurgitation of the tumor mass in the mouth which may , in some cases , lead to asphyxia and death . | NA | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
119,
127
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
132,
137
]
} |
in order to investigate the cellular mechanism of glucocorticoid resistance in chronic asthma , peripheral blood mononuclear cells ( mnc ) from asthmatic patients were cultured in soft agar . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
28,
36
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
96,
130
]
} |
the results raise the possibility that peripheral blood mononuclear cells may respond to glucocorticoid in a similar manner to cells involved in the pathogenesis of asthma . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
39,
67
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} |
predictions of serum gentamicin concentration and half-life , using a personal-computer software system ( simkin [ simulated kinetics ] ) , were compared for accuracy as increasing amounts of patient-specific data were supplied to the computer . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
50,
59
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
125,
133
]
} |
formaldehyde , acetaldehyde , malondialdehyde , glutaraldehyde and paraldehyde , when added in vitro to platelet-rich plasma , generate a similar distinct platelet aggregation response which is dose dependent when measured with a manual visual microscopic technique and by computerized image analysis , 'computerized platelet aggregation analysis ' . | NA | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
15,
27
]
} | {
"id": "C0030438",
"name": "paraldehyde",
"pos": [
67,
78
]
} |
the aggregating reaction was specific to the aldehyde group and was not seen when the aldehyde was replaced by an alcohol , ketone , or acetate group in the case of acetaldehyde . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
45,
53
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
165,
177
]
} |
the clinical presentation of pulmonary embolism may be dominated by manifestations of pulmonary infarction or by the signs and symptoms of an acute hemodynamic disturbance . | NA | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
29,
47
]
} | {
"id": "C0034074",
"name": "pulmonary infarction",
"pos": [
86,
106
]
} |
herpes simplex virus ( hsv ) was isolated from clinical specimens more rapidly in mink lung ( ml ) cells , a continuous cell line available from a commercial supplier , than in vero cells or human fibroblast ( hf ) cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
99,
104
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
197,
207
]
} |
stock strains of hsv type 1 ( hsv-1 ) and hsv-2 titered higher in ml cells than in vero or hf cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} | {
"id": "C0016030",
"name": "hf",
"pos": [
91,
93
]
} |
ceftriaxone , ceftizoxime , and cefotaxime were the most active of the study antibiotics ( mic90 = 0.004-0.016 micrograms/ml ) , and were also bactericidal at concentrations no more than twice the minimum inhibitory concentration ( mic ) . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
0,
11
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
32,
42
]
} |
ceftriaxone , ceftizoxime , and cefotaxime were the most active of the study antibiotics ( mic90 = 0.004-0.016 micrograms/ml ) , and were also bactericidal at concentrations no more than twice the minimum inhibitory concentration ( mic ) . | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
14,
25
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
32,
42
]
} |
the bacteriostatic and bactericidal activity of gentamicin , amikacin , piperacillin , azlocillin , ampicillin , benzyl penicillin , and oxacillin against 85 selected isolates was measured alone and in the presence of subinhibitory concentrations of cefotetan . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
72,
84
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
100,
110
]
} |
the bacteriostatic and bactericidal activity of gentamicin , amikacin , piperacillin , azlocillin , ampicillin , benzyl penicillin , and oxacillin against 85 selected isolates was measured alone and in the presence of subinhibitory concentrations of cefotetan . | NA | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
87,
97
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
100,
110
]
} |
the bacteriostatic and bactericidal activity of gentamicin , amikacin , piperacillin , azlocillin , ampicillin , benzyl penicillin , and oxacillin against 85 selected isolates was measured alone and in the presence of subinhibitory concentrations of cefotetan . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
100,
110
]
} | {
"id": "C0030827",
"name": "benzyl penicillin",
"pos": [
113,
130
]
} |
a potential for antagonistic interactions between cefotetan and acylamino penicillins ( piperacillin greater than azlocillin greater than ampicillin ) were observed with some strains ; | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
88,
100
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
138,
148
]
} |
a potential for antagonistic interactions between cefotetan and acylamino penicillins ( piperacillin greater than azlocillin greater than ampicillin ) were observed with some strains ; | NA | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
114,
124
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
138,
148
]
} |
twenty-four hr after t3-injection the norepinephrine ( ne ) content of plasma declined , whereas epinephrine ( e ) titres increased . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
97,
108
]
} |
both alpha 1- and alpha 2-adrenoceptors have been located postsynaptically . alpha-adrenoceptors have been found also in the central nervous system . | NA | {
"id": "C0001639",
"name": "alpha 2-adrenoceptors",
"pos": [
18,
39
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
77,
96
]
} |
all three ( - ) -catecholamines tested inhibited migration with the following order of effectiveness : isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
17,
31
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
103,
116
]
} |
all three ( - ) -catecholamines tested inhibited migration with the following order of effectiveness : isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
130,
141
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
155,
169
]
} |
malaysian fish generally contained high levels of saturated fatty acids ( range 36-55 % total fatty acids ) and contained variable amounts of monounsaturates , chiefly palmitic and stearic acids , but only trace levels of 20:1 and 22:1 . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
60,
71
]
} | {
"id": "C0038230",
"name": "stearic acids",
"pos": [
181,
194
]
} |
unlike fish caught in colder northern hemisphere waters , malaysian fish were found to contain arachidonic acid ( 20:4 omega 6 , range 2-12 % ) in addition to the expected eicosapentaenoic acid ( 20:5 omega 3 , range 1-13 % ) and docosahexaenoic acid ( 22:6 omega 3 , range 6.6-40.4 % ) . | NA | {
"id": "C0012968",
"name": "docosahexaenoic acid",
"pos": [
230,
250
]
} | {
"id": "C0015689",
"name": "omega 3",
"pos": [
258,
265
]
} |
the amounts of eight putative neurotransmitters or modulators ( acetylcholine , dopamine , noradrenaline , adrenaline , gaba , taurine , glutamic acid , glycine ) were determined from the cns of 12 species of five different spider families ( theraphosidae , agelenidae , araneidae , lycosidae , salticidae ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
91,
104
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
107,
117
]
} |
dopaminergic terminals were labelled with both dopa and dopamine and the morphology is similar to other da synapses . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
0,
12
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
104,
106
]
} |
in the submandibular glands , alpha-mna activates alpha-adrenoceptors at higher doses whereas at relatively lower doses it activates beta-adrenoceptors . alpha-mna may not stimulate the specific alpha 2-adrenoceptors of the salivary glands of rats . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
50,
69
]
} | {
"id": "C0001639",
"name": "alpha",
"pos": [
195,
200
]
} |
spontaneous gh peaks were not observed following the administration of ( 1 ) bis- ( 4-methyl-1-homopiperazinyl-thiocarbonyl ) disulfide ( fla63 ) or diethyldithiocarbamate ( ddc ) ( which blocks norepinephrine ( ne ) and epinephrine ( e ) synthesis by inhibiting dopamine-beta-hydroxylase ) , ( 2 ) phenoxybenzamine ( an alpha 1-adrenergic antagonist ) and ( 3 ) clonidine ( an alpha 2-adrenergic agonist ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
195,
209
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
221,
232
]
} |
the effects of waterborne fluoride ( naf ) on growth , reproduction and survival in daphnia magna were studied from subnormal to toxic concentrations in hard reconstituted water . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
26,
34
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
37,
40
]
} |
the thermal properties of fish collagens depend significantly on the content of hydroxyproline and proline residues which in turn is correlated to the temperature of the habitat . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
80,
94
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
99,
106
]
} |
a fall in iop induced by epinephrine ( epi ) or norepinephrine ( nor-epi ) is partly reversed by the addition of ach . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
48,
62
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
69,
72
]
} |
a promising new nucleoside analog , 9- [ [ 2-hydroxy-1- ( hydroxymethyl ) ethoxy ] methyl ] -guanine ( bw759 ) , which is structurally similar to acyclovir , was tested against acute herpetic keratitis in the rabbit ocular model . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
93,
100
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
146,
155
]
} |
none of these patients had any associated systemic mesenchymal disease ( lupus erythematosus , periarteritis nodosa , rheumatoid arthritis , sjogren 's syndrome , or carcinomatous diseases ) . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
118,
138
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
141,
160
]
} |
the accuracy of three methods of equilibrium radionuclide analysis for measuring rvef was compared in several subgroups of patients with a variety of cardiac diseases , including congenital and valvular heart disease , cor pulmonale , and cardiomyopathy . | NA | {
"id": "C0018799",
"name": "cardiac diseases",
"pos": [
150,
166
]
} | {
"id": "C0018824",
"name": "valvular heart disease",
"pos": [
194,
216
]
} |
the accuracy of three methods of equilibrium radionuclide analysis for measuring rvef was compared in several subgroups of patients with a variety of cardiac diseases , including congenital and valvular heart disease , cor pulmonale , and cardiomyopathy . | NA | {
"id": "C0018799",
"name": "cardiac diseases",
"pos": [
150,
166
]
} | {
"id": "C0034072",
"name": "cor",
"pos": [
219,
222
]
} |
while more than a half of the 102 freshly isolated neisseria gonorrhoeae strains examined was partially or totally resistant to penicillin ( mic greater than or equal to 0.06 microgram/ml ) , most of these strains proved highly susceptible to ceftizoxime ( as well as cefotaxime ) . | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
243,
254
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
268,
278
]
} |
in vitro activity of cefmenoxime , cefotaxime , latamoxef , cefazolin , nafcillin and vancomycin against 53 endocarditis and bacteremic strains of staphylococcus aureus . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
21,
32
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
35,
45
]
} |
antistaphylococcal activity of newer beta-lactam antibiotics , cefmenoxime , cefotaxime and latamoxef was compared with that of the more conventional antistaphylococcal agents , nafcillin , cefazolin and vancomycin . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
63,
74
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
77,
87
]
} |
minimal concentration of antibiotic to inhibit 90 % of strains tested was 2 micrograms/ml for cefmenoxime and cefotaxime , 8 micrograms/ml for latamoxef and only 0.5 microgram/ml for nafcillin , cefazolin and vancomycin . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
94,
105
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
110,
120
]
} |
the patients were divided into 5 groups receiving equally cefotaxime 3 x 2 g , lamoxactam 3 x 2 g , cefmenoxime 3 x 1 g , mezlocillin 3 x 5 g an piperacillin 3 x 4 g . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
58,
68
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
100,
111
]
} |
by increasing the chromate concentrations ( greater than 2 microm k2cr2o7 ) the cells are also arrested in g2 phase . | NA | {
"id": "C0008543",
"name": "chromate",
"pos": [
18,
26
]
} | {
"id": "C0032829",
"name": "k2cr2o7",
"pos": [
66,
73
]
} |
effects of dietary butter fat on fecal bile acid excretion in patients with crohn 's disease on elemental diet . | NA | {
"id": "C0012171",
"name": "dietary",
"pos": [
11,
18
]
} | {
"id": "C0006494",
"name": "butter",
"pos": [
19,
25
]
} |
such clones constitutively produce up to 350,000 units ifn/ml per 10 ( 6 ) cells/24 hr , i.e. , over 10 times more than fully induced human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
75,
80
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
140,
151
]
} |
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