text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the cloned viral dnas were identified by digestion of the recombinant dnas with various restriction enzymes followed by comparison of their electrophoretic mobilities in agarose gels with that of similarly digested uncloned dnas . | NA | {
"id": "C0012939",
"name": "viral dnas",
"pos": [
11,
21
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
224,
228
]
} |
the cloned viral dnas were identified by digestion of the recombinant dnas with various restriction enzymes followed by comparison of their electrophoretic mobilities in agarose gels with that of similarly digested uncloned dnas . | NA | {
"id": "C0012931",
"name": "recombinant dnas",
"pos": [
58,
74
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
224,
228
]
} |
a plasmid carrying a dna sequence conferring amber suppression has been isolated from yeast pool 35 dna . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
19,
24
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
100,
103
]
} |
biochemical analysis of these gags revealed that 57 % -70 % of the tissue gags were hyaluronic acid , 16 % -33 % heparan sulphate and 12 % -22 % various types of chondroitin sulphate . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
30,
34
]
} | {
"id": "C0019143",
"name": "heparan",
"pos": [
113,
120
]
} |
these cultures synthesized tissue-bound and medium-released ( `` '' excreted '' '' ) glycosaminoglycans ( gags ) , as evidenced by the incorporation of 14c-glucosamine and enzymatic characterization of these labelled gags ( hyaluronic acid , heparan sulphate , chondroitin sulphate , dermatan sulphate ) . | NA | {
"id": "C0017973",
"name": "d ga",
"pos": [
215,
219
]
} | {
"id": "C0019143",
"name": ", hepar",
"pos": [
240,
247
]
} |
[ the state and relation between various indicators of the body 's natural resistance in patients with silicosis and silicotuberculosis ] . | NA | {
"id": "C0037116",
"name": "silicosis",
"pos": [
103,
112
]
} | {
"id": "C0037118",
"name": "silicotuberculosis",
"pos": [
117,
135
]
} |
two commonly taken over-the-counter analgesics , aspirin and acetaminophen , were compared for : effect on total menstrual loss , effect on total days of menstruation , and effect in reduction of pain due to headaches and/or menstrual cramps . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
196,
200
]
} | {
"id": "C0018681",
"name": "headaches",
"pos": [
208,
217
]
} |
neither analgesic showed a significant reduction in pain due to headache or cramps , although acetaminophen appeared to be slightly more effective than aspirin in reducing menstrual cramps . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
52,
56
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
64,
72
]
} |
in eighteen cases of condylar , subcapital and other intraarticular fractures of phalanges , especially in cases of fractures in childhood cerclage and suture with dexon were used . | NA | {
"id": "C0332715",
"name": "intraarticular fractures",
"pos": [
53,
77
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
116,
125
]
} |
it was demonstrated by observing ed50 values that nonsteroidal antiinflammatory drugs ( nsaids ) , narcotic analgesic drugs and agonist/antagonist type of analgesic drugs were effective , but cns-acting drugs were ineffective in yeast hyperalgesia mice . | NA | {
"id": "C0002771",
"name": "analgesic",
"pos": [
108,
117
]
} | {
"id": "C0007680",
"name": "cns",
"pos": [
192,
195
]
} |
all benzodiazepines used in this study ( diazepam , chlordiazepoxide , bromazepam , flurazepam , medazepam , nitrazepam , oxazepam , oxazolazepam , lorazepam , estazolam and triazolam ) were administered into the duodenum via a rubber tube implanted previously . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
4,
19
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
52,
68
]
} |
all benzodiazepines used in this study ( diazepam , chlordiazepoxide , bromazepam , flurazepam , medazepam , nitrazepam , oxazepam , oxazolazepam , lorazepam , estazolam and triazolam ) were administered into the duodenum via a rubber tube implanted previously . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
4,
19
]
} | {
"id": "C0025051",
"name": "medazepam",
"pos": [
97,
106
]
} |
the fetal heart rates were accelerated by the administration of isoproterenol , epinephrine , norepinephrine , tyramine and dopamine to fetuses , and they were decelecated by the injection of propranolol and methacholine to fetuses . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
94,
108
]
} |
control rats were given untreated feed or drinking-water and nitrite-treated controls were given sodium nitrite at a concentration of 0.2 % in feed or drinking-water . | NA | {
"id": "C0028137",
"name": "nitrite",
"pos": [
61,
68
]
} | {
"id": "C0037532",
"name": "sodium nitrite",
"pos": [
97,
111
]
} |
one of the possible reasons for the observed absence of inhibition by vitamin a in vivo may be a lack of correlation between the oral dose of retinoid and the resulting level of vitamin a in the bone marrow . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
70,
79
]
} | {
"id": "C0035339",
"name": "retinoid",
"pos": [
142,
150
]
} |
these data demonstrate further that , in the juvenile type of acanthosis nigricans , insulin resistance which may precede hyperinsulinism is not related to anti-insulin antibodies nor to antireceptor antibodies , but results from a primary defect of insulin receptors . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
85,
103
]
} | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
122,
137
]
} |
comparative inhibition studies revealed that the antigen binding t8+ cells , unlike mo , are inhibited with monoclonal anti-t8 and -t5 antibodies and anti-suppressor factor antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
135,
145
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
173,
182
]
} |
culturing peripheral blood ( pb ) mnc for 24 hr did not alter scmc nor the proportion of leu-7+ cells . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
10,
26
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
71,
74
]
} |
this protein was confirmed as the canine analogue of c-reactive protein ( crp ) in other species by virtue of its electron microscopic appearance , subunit composition and behaviour as an acute phase reactant . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
53,
71
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
188,
208
]
} |
monoclonal igg1 antibody to horseradish peroxidase was used in order to quantitate such a transfer of antigen , using the electron microscope and also studies with radiolabelled antigen and/or antibody . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
0,
10
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
193,
201
]
} |
these effects , however , were greatly dependent on the in vitro or in vivo conditions of the stimulation and the type of polyclonal activator used and antibody assayed ( isotype and specificity ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
152,
160
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
171,
178
]
} |
in vitro activity of n-formimidoyl thienamycin ( mk 0787 ) compared with other beta-lactamase stable cephalosporins against beta-lactamase producing staphylococcus aureus . | NA | {
"id": "C0728805",
"name": "beta-lactamase",
"pos": [
79,
93
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
124,
138
]
} |
[ antibacterial activity of clindamycin and lincomycin in broth , serum , and in combination with polymorphonuclear leukocytes against staphylococcus aureus and staphylococcus epidermidis ] . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
28,
39
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
44,
54
]
} |
we investigated the antibacterial activity of clindamycin and lincomycin at 1/4 x minimum inhibitory concentration ( mic ) , 1 x mic and 4 x mic against a serum-resistant staphylococcus aureus and a serum-resistant staphylococcus epidermidis strain in broth , in serum with and without the presence of leukocytes and in hank 's medium in combination with leukocytes alone . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
46,
57
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
62,
72
]
} |
against both test strains , lincomycin in broth and serum was similarly effective , whereas against s. aureus clindamycin in broth was somewhat more active . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
28,
38
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
110,
121
]
} |
in the combined test mixture of serum with leukocytes , even a 1/4 x mic of clindamycin or lincomycin markedly improved leukocyte killing of s. aureus , whereas both compounds could not further enhance the marked leukocyte killing of s. epidermidis , even at inhibitory concentrations . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
76,
87
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
91,
101
]
} |
in hank 's medium with leukocytes alone , clindamycin and lincomycin had at the most only a bacteriostatic effect against both test strains . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
42,
53
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
58,
68
]
} |
in murine protection tests with these strains , it was clearly superior to ceftazidime , cefotaxime , ceftriaxone , cefoperazone and latamoxef . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
89,
99
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
102,
113
]
} |
the compounds most effective in protecting mice from infections caused by enterobacteriaceae were hr810 and ceftriaxone followed by ceftazidime , latamoxef and cefotaxime ; | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
108,
119
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
160,
170
]
} |
such antibodies , of both the igg and the igm isotype , opsonized e. coli k13 in vitro and protected against intraperitoneal infection in mice as well as ascending pyelonephritis in rats . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
5,
15
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
46,
53
]
} |
merrifield resins with various amino acid containing pendants and a water swellable polyamide resin with the peptide alanine-alanine-alanine-arginine as the pendant group have been prepared by solid phase peptide synthesis . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
31,
41
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
133,
140
]
} |
cal-1 and cal-2 cells both expressed viral proteins with apparent molecular weights of 53 kd , 24 kd and 19 kd , and cal-2 cells also expressed 28 kd and 20 kd proteins . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
37,
51
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
160,
168
]
} |
mononuclear phagocytes , an integral part of the lymphoreticular infiltrate of human and experimental tumors , might contribute to tumor-associated fibrin deposition through the development of procoagulant activity ( pca ) . | NA | {
"id": "C0027659",
"name": "experimental tumors",
"pos": [
89,
108
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
131,
136
]
} |
the hypothesis that high nitrate ingestion may increase the risk of stomach cancer has led to concern over rising levels of nitrate in drinking water , but with little consideration as to whether nitrate from water makes a major contribution to total nitrate intake . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
135,
149
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
209,
214
]
} |
in order to investigate the relative importance of water and food as sources of nitrate , 404 adult well-water users completed a diet diary over a 48-hour period and provided a 24-hour urine specimen and a sample of their drinking water . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
51,
56
]
} | {
"id": "C0599638",
"name": "sample",
"pos": [
206,
212
]
} |
this combination of ief and proteases histochemistry yields excellent and reproducible data which can not be obtained by protease histochemistry alone . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
28,
37
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
121,
129
]
} |
during the entire estrous cycle , 3 alpha-hydroxysteroid dehydrogenase and 3 beta-hydroxysteroid dehydrogenase activity can be found in the theca of tertiary follicles and in the interstitial cells , whereas the theca of secondary follicles and the granulosa of healthy follicles do not exhibit any enzyme activity . | NA | {
"id": "C0048751",
"name": "3 alpha-hydroxysteroid dehydrogenase",
"pos": [
34,
70
]
} | {
"id": "C0000413",
"name": "3 beta-hydroxysteroid",
"pos": [
75,
96
]
} |
acetylcholinesterase and butyrylcholinesterase were demonstrated , by electron-microscopic examination of both muscle layers of the guinea-pig ductus deferens , to be localized on the axolemma of the nerve endings and in smooth-muscle fibres , on sarcolemma , in the intracellular caveolae and in the intercellular space . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
0,
20
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
25,
46
]
} |
quantitative correlation between phosphorus and potassium as well as the similar distribution of these elements suggests that in acanthamoeba phosphorus is an essential anion which , being nonuniformly distributed in the cell , determines also a nonuniform distribution of potassium . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
103,
111
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
142,
152
]
} |
conversely , dexamethasone had no effect on the radiosensitivity of chinese hamster ovary cells , murine fibrosarcoma , rat glioma cells , human diploid fibroblasts , or human mammary carcinoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
153,
164
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
194,
199
]
} |
in the present study , we used dome-forming monolayers to study the regulation of alveolar epithelial transport processes by determining the effects on dome formation of adenosine 3',5'-cyclic monophosphate ( camp ) analogues , phosphodiesterase inhibitors , neurotransmitters , and vasopressin ( antidiuretic hormone , adh ) . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
283,
294
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
297,
317
]
} |
in six normal supine subjects epinephrine infusion produced a greater leukocytosis with smaller changes in heart rate and blood pressure than did norepinephrine or isoproterenol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
146,
160
]
} |
the present study sought to quantitate the levels of plasma catecholamines [ norepinephrine ( ne ) , epinephrine ( e ) , and dopamine ( da ) ] during induction and rewarming from hypothermia . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
77,
91
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
101,
112
]
} |
this report describes a case in a nineteen-year-old in which fetal ascites was documented in the midtrimester of pregnancy and in which subsequent regression was shown by ultrasound . | NA | {
"id": "C0032980",
"name": "midtrimester",
"pos": [
97,
109
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
113,
122
]
} |
in the inner layer of the uterus that corresponds to the endometrial stroma , in addition to fibroblast-like cells , there were cells with plump cytoplasm which contained well developed granular endoplasmic reticulum and golgi apparatus and which were identified around blood vessels by 26 weeks . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
93,
103
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
the gm were larger in w than in l for dam weight and feed consumption , and for litter size and weight at birth , but they were usually of smaller magnitude than gd . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
42,
48
]
} | {
"id": "C0005612",
"name": "weight",
"pos": [
96,
102
]
} |
in nine consecutive hospitalized patients treated with either ampicillin or amoxycillin , studies on the pharmacokinetics of orally administered amoxycillin and bacampicillin gave a mean absorption of 73 % ( +/- 15 % ) of the dose for amoxycillin and 65 % ( +/- 17 % ) for bacampicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
62,
72
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
235,
246
]
} |
cassava polysaccharides were degraded to oligosaccharides , maltotriose , maltose , and glucose beyond the 20-h growth periods , with maltotriose emerging as the major simple sugar . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
8,
23
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
41,
57
]
} |
it hydrolyzed beta-naphthylamides of basic , aliphatic , and aromatic amino acids , and also catalyzed the liberation of amino-terminal phenylalanine from phenylalanyl peptides . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
61,
81
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
136,
149
]
} |
the kinetic properties of each isozyme were analyzed with respect to the natural substrates gmp and dgmp , and the 5'-monophosphate derivatives of the antiviral nucleoside analogs 9- ( 1,3-dihydroxy-2-propoxymethyl ) guanine ( dhpg ) and 9- ( 2-hydroxyethoxymethyl ) guanine ( acv , acyclovir ) . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
227,
231
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
283,
292
]
} |
the kinetic properties of each isozyme were analyzed with respect to the natural substrates gmp and dgmp , and the 5'-monophosphate derivatives of the antiviral nucleoside analogs 9- ( 1,3-dihydroxy-2-propoxymethyl ) guanine ( dhpg ) and 9- ( 2-hydroxyethoxymethyl ) guanine ( acv , acyclovir ) . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
217,
224
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
283,
292
]
} |
gmp produced the highest enzyme velocities with all isozymes , followed by dgmp , dhpg 5'-monophosphate , and acv 5'-monophosphate , in that order . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
25,
31
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
52,
60
]
} |
amino acid composition and n-terminal analysis suggested the sequence of the flavin-peptide of sarcosine dehydrogenase was his ( flavin ) - ( ala , gly , thr ) -leu . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
148,
151
]
} |
the vv6 cells contained a series of o-linked oligosaccharides ranging in size from a disaccharide to a pentasaccharide . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
45,
61
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
85,
97
]
} |
kinetic data for the 6'-aminoglycoside-modifying enzyme , aac ( 6 ' ) -4 , also named kanamycin acetyltransferase , have been collected for six aminoglycoside antibiotics ( amikacin , gentamicin c1a , kanamycin a , neomycin b , sisomicin , and tobramycin ) and three coenzymes ( acetyl-coa , n-propionyl-coa , and n-butyryl-coa ) . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
173,
181
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
201,
210
]
} |
membrane vesicles of streptococcus lactis were used to characterize a novel anion exchange involving phosphate and sugar 6-phosphates . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
76,
81
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
123,
132
]
} |
the plasmids studied are adr2-bs-pbr322 ( the vector pbr322 + the yeast gene adr2 ) , adr3-5c-yrp7 ( containing yeast trp1 , a constitutive mutant of yeast adr2 , a fragment of 5 kilobases of unanalyzed chromosomal dna and the vector pbr322 ) , and p31 ( pbr322 + a yeast dna fragment encompassing the right moiety of the ty1 element and its in vivo promoter ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
272,
275
]
} |
factor b is the zymogen of the catalytic site bearing subunit bb of the c3/c5 convertase of the alternative pathway of complement . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
0,
8
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
119,
129
]
} |
under physiological conditions , integration of lambda dna into the escherichia coli chromosome requires the direct participation of only two proteins , the viral int gene product and e. coli integration host factor ( ihf ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
142,
150
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
157,
162
]
} |
this glycoconjugate was found to have an apparent molecular weight of 200,000 and to consist of peptide and carbohydrate in a ratio of 70 to 30 . | NA | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
5,
19
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
108,
120
]
} |
the new carboxyl terminus is 16 amino acids longer than the gamma a protein , and although there is only minimal homology between the rat and human carboxyl termini they share a very high proportion of acidic amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
32,
43
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
202,
220
]
} |
factor v and factor va exhibited absorption spectra with no maxima at either 310 or 610 nm , indicating that the copper is not bound in a site analogous to type i or type iii copper sites in ceruloplasmin . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
0,
8
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
13,
22
]
} |
further , factor v and factor va are not capable of serving as catalysts for the oxidation of n , n-dimethyl-p-phenylenediamine under solution conditions that are optimum for ceruloplasmin oxidase activity . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
10,
18
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
23,
32
]
} |
both the culture medium pool and the cell-associated fraction of heparan sulfate contained proteoheparan sulfate plus a polydisperse mixture of heparan chains which were attached to little , if any , protein . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
65,
80
]
} | {
"id": "C0062503",
"name": "proteoheparan sulfate",
"pos": [
91,
112
]
} |
demonstration of atp binding to the enzyme-vanadate complex provides further support for the suggestion that the oligomeric enzyme contains a low-affinity regulatory site for atp that is distinct from the interacting high-affinity catalytic sites . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
36,
42
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
124,
130
]
} |
to examine the kinetics of opioid receptor binding , the agonists [ d-ala2-d-leu5 ] enkephalin ( dadl ) and [ d-ala2-mephe4-gly-ol5 ] enkephalin ( dago ) and the antagonists diprenorphine and naltrexone were used with bovine hippocampal synaptic plasma membranes . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
84,
94
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
147,
151
]
} |
ovoperoxidase catalyzes the oxidation of tyrosine , guaiacol , iodide , and bromide , but not chloride , and can employ either h2o2 or , with 8 % relative efficiency , ethyl peroxide as an oxidative substrate . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
127,
131
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
174,
182
]
} |
exposure of granules to selected anions also causes lysis , increasing in the order sulfate less than phosphate less than or equal to gluconate less than or equal to isethionate less than or equal to acetate less than or equal to chloride much less than thiocyanate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
33,
39
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
84,
91
]
} |
exposure of granules to selected anions also causes lysis , increasing in the order sulfate less than phosphate less than or equal to gluconate less than or equal to isethionate less than or equal to acetate less than or equal to chloride much less than thiocyanate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
33,
39
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
102,
111
]
} |
exposure of granules to selected anions also causes lysis , increasing in the order sulfate less than phosphate less than or equal to gluconate less than or equal to isethionate less than or equal to acetate less than or equal to chloride much less than thiocyanate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
33,
39
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
230,
238
]
} |
the order of potency of a series of alpha-adrenoreceptor agonists was ( - ) -adrenaline greater than oxymetazoline greater than ( +/- ) -na approximately ( - ) -phenylephrine greater than methoxamine in the mca and ( +/- ) -na greater than ( - ) -phenylephrine in the ma . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
224,
226
]
} |
we present data indicating that the secretory phenotype of cultured rat aortic smooth muscle cells can be modulated by exogenous soluble heparin , heparan sulfate , and dermatan sulfate glycosaminoglycans . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
137,
144
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
186,
204
]
} |
we present data indicating that the secretory phenotype of cultured rat aortic smooth muscle cells can be modulated by exogenous soluble heparin , heparan sulfate , and dermatan sulfate glycosaminoglycans . | NA | {
"id": "C0019143",
"name": "heparan",
"pos": [
147,
154
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
186,
204
]
} |
cell surface hspg aligned with microfilament bundles of rat embryo fibroblasts seen by phase-contrast microscopy but was diffuse on transformed rat dermal fibroblasts ( 16c cells ) which lack obvious stress fibers . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
67,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
double immunofluorescent staining of fully adherent rat embryo fibroblast cells showed some co-distribution of hspg and fn , and this was confirmed by immunoelectron microscopy , which detected hspg at localized areas of dorsal and ventral cell membranes , overlapping cell margins , and in the extracellular matrix . | NA | {
"id": "C0016030",
"name": "fibroblast cells",
"pos": [
63,
79
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
300,
304
]
} |
expression of unusually large keratins during terminal differentiation : balance of type i and type ii keratins is not disrupted . | NA | {
"id": "C0010803",
"name": "keratins",
"pos": [
30,
38
]
} | {
"id": "C1179973",
"name": "type ii keratins",
"pos": [
95,
111
]
} |
the striking similarities between these large keratins and the type i and type ii keratins of basal epidermal cells suggests the important role that both classes of large keratin sequences must play in the assembly of the intermediate filaments within the differentiating keratinocyte . | NA | {
"id": "C1179973",
"name": "type ii keratins",
"pos": [
74,
90
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
272,
279
]
} |
other nonmitogen-secreting cells in culture , including bovine dermal fibroblasts and vascular smooth muscle cells , also contained a similar activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
70,
81
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
109,
114
]
} |
to investigate the effect of cell density on sm-c/igf-i activity , we have evaluated sm-c/igf-i binding and stimulation of dna synthesis and cell replication as a function of cell density in cultured human fibroblast monolayers . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
15,
18
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
206,
216
]
} |
at fibroblast concentrations of 2.7 x 10 ( 5 ) and 1.48 x 10 ( 6 ) cells per 60-mm dish , specific binding of [ 125i ] sm-c/igf-i per 10 ( 6 ) cells was 170 % higher in sparse than dense monolayers ( 9.3 % vs. 3.4 % ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
3,
13
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} |
progressive decreases in the number of functional receptors , secondary to cell crowding , may contribute to density-dependent inhibition of fibroblast growth . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
75,
79
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
141,
151
]
} |
lymphoblastoid daudi cells , which are highly sensitive to growth inhibition by interferon ( ifn ) , can be grown in a defined serum-free medium containing insulin , transferrin , and albumin as the only proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
184,
191
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
204,
212
]
} |
in practice the chromatographic resolution of membrane proteins was lower than for water-soluble proteins , perhaps due to protein-protein interactions and microheterogeneity , but several components , or groups of components , separated well upon salt gradient elution . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
46,
63
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
97,
105
]
} |
the application of high-performance liquid chromatography to resolve the individual alkaloids present in marketed cinchona alkaloids was investigated . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
84,
93
]
} | {
"id": "C0008792",
"name": "cinchona alkaloids",
"pos": [
114,
132
]
} |
solubilization of plasma membranes in anionic , non-ionic and zwitterionic surfactants for iso-dalt analysis : a critical evaluation . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
38,
45
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
69,
74
]
} |
to determine the importance of substrate ( 25-hydroxyvitamin d ) concentration in this phenomenon , five patients with end stage renal disease treated with hemodialysis were given 25-hydroxyvitamin d3 ( 25-oh-d3 ) orally for 4 weeks . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
180,
200
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
203,
211
]
} |
we conclude that cultured fibroblasts from patients with familial generalized resistance to thyroid hormone display abnormal kinetics of t3 nuclear uptake which provide a convenient in vitro method for the recognition of thyroid hormone resistance at the cell level . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
26,
37
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
255,
259
]
} |
sex hormones [ fsh , lh , androstenedione ( a ) , testosterone , estrone , and 17 beta-estradiol ( e2 ) ] , stress hormones [ dehydroepiandrosterone , cortisol ( f ) , prl , norepinephrine , and epinephrine ] and psychological status ( profile of mood states and state-trait anxiety inventory ) were measured at rest and in response to a 40-min 80 % of maximal aerobic power ( vo2max ) run in highly trained eumenorrheic ( n = 8 ) and amenorrheic ( n = 7 ) women runners matched for fatness [ eumenorrheic , 16.5 +/- 2.3 % ( +/- sd ) ; amenorrheic , 14.9 +/- 4.8 ] and maximal aerobic power ( eumenorrheic , 58.9 +/- 5.7 ml/kg x min ; amenorrheic , 59.8 +/- 4.6 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
174,
188
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
195,
206
]
} |
in the absence of plasma proteins , estrone ( e1 ) and estradiol ( e2 ) were freely diffusible through the uterine capillaries , but influx was significantly reduced for estriol ( e3 ) and estetrol . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
170,
177
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
189,
197
]
} |
in contrast , dhea-s levels were significantly lower than those of normal subjects in all 28 patients with hyperadrenocorticism due to benign adrenocortical adenoma , suggesting that acth is the major determinant of dhea-s secretion and that determination of serum dhea-s concentrations is useful in the biochemical differential diagnosis of the etiology of cushing 's syndrome . | NA | {
"id": "C0001622",
"name": "hyperadrenocorticism",
"pos": [
107,
127
]
} | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
358,
377
]
} |
the responses of epinephrine and norepinephrine were delayed but adequate compared with those in normal subjects . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} |
these results suggest that glucagon responses are essential to recover from hypoglycemia and that neither epinephrine nor norepinephrine plays a crucial role in the recovery from acute insulin-induced hypoglycemia in totally pancreatectomized patients . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
106,
117
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
122,
136
]
} |
after separation by acidic gel filtration , the samples were assayed for igf using a protein-binding assay ( which measures mainly igf i-related peptides ) and for igf bp by titration , in both cases using igf i as tracer . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
73,
76
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
206,
211
]
} |
a second procoagulant activity was produced in response to endotoxin ( lps ) by cells from controls and patients with whipple 's disease and was identified as thromboplastin . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
59,
68
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
71,
74
]
} |
a double-antibody enzyme immunoassay was developed for the identification and typing of herpes simplex virus ( hsv ) by employing a polyclonal rabbit capture antiserum together with type-common and type 2-specific monoclonal antibodies as detectors . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
9,
17
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
158,
167
]
} |
a double-antibody enzyme immunoassay was developed for the identification and typing of herpes simplex virus ( hsv ) by employing a polyclonal rabbit capture antiserum together with type-common and type 2-specific monoclonal antibodies as detectors . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
9,
17
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
214,
235
]
} |
double-antibody sandwich procedures , which use the same antiserum preparation for coating the wells of microtiter plates and for alkaline phosphatase-conjugated immunoglobulin , differentiated meningococcal csfs from control specimens but were unable to effectively differentiate the haemophilus or pneumococcal specimens from control csfs . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
7,
15
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
57,
66
]
} |
cell extracts from two representative strains phosphorylated and inactivated kanamycin , amikacin , gentamicin , tobramycin , 3',4'-dideoxykanamycin b ( dibekacin ) , butirosin , lividomycin , and ribostamycin , which together constituted a novel spectrum of substrates for the enzymatic activity . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
77,
86
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
89,
97
]
} |
cell extracts from two representative strains phosphorylated and inactivated kanamycin , amikacin , gentamicin , tobramycin , 3',4'-dideoxykanamycin b ( dibekacin ) , butirosin , lividomycin , and ribostamycin , which together constituted a novel spectrum of substrates for the enzymatic activity . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
77,
86
]
} | {
"id": "C0012024",
"name": "dibekacin",
"pos": [
153,
162
]
} |
by elisa with a polyclonal serum as capture antibody and a mixture of mabs as detector antibody , we were able to detect from 10 ( 2.2 ) to 10 ( 5.8 ) 50 % tissue culture infective doses of virus and to type lyophilized isolates of ev-70 sent from taiwan from which we could not recover infectious virus . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
70,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
87,
95
]
} |
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