text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a potency order ( - ) -isoprenaline greater than ( - ) -noradrenaline greater than ( - ) -adrenaline was established , indicating a beta 1-adrenoceptor involvement for this relaxation . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
56,
69
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
90,
100
]
} |
[ solvent system design for silica gel liquid chromatography of digitalis glycosides . determination of digoxin in pharmaceutical preparation ] . | NA | {
"id": "C0012253",
"name": "digitalis",
"pos": [
64,
73
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
104,
111
]
} |
phenytoin displayed nonlinear pharmacokinetics in the dogs , complicating the determination of the absolute bioavailability of phenytoin from sodium phenytoin and the prodrugs . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
0,
9
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
142,
158
]
} |
all three prodrugs essentially released phenytoin after intravenous administration in a quantitative manner , and all gave plasma levels of phenytoin after oral administration greater than those found after administration of sodium phenytoin . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
40,
49
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
225,
241
]
} |
to confirm the release of phenytoin from this prodrug , phenytoin availability after intramuscular and intravenous administrations of the phosphate prodrug was evaluated in rats and compared with sodium phenytoin . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
26,
35
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
196,
212
]
} |
the prodrug quantitatively released phenytoin after intravenous administration , and phenytoin levels from intramuscular administration of the prodrug were far superior to those generated from similarly administered sodium phenytoin . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
36,
45
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
216,
232
]
} |
the in vivo differences between pregnant and nonpregnant rats with respect to phenytoin binding in plasma are not due to differences in fatty acid concentrations , but the in vitro differences are due primarily to corresponding differences in free fatty acid concentrations if extensive in vitro lipolysis occurs . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
136,
146
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
243,
258
]
} |
a reverse-phase high-performance liquid chromatographic method for the quantitation of phenobarbital and phenobarbital sodium in pharmaceutical dosage forms ( elixir , injection , and tablets ) was developed . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
87,
100
]
} | {
"id": "C0282303",
"name": "phenobarbital sodium",
"pos": [
105,
125
]
} |
by applying the same system parameters used for chlorothiazide , the model simulation correctly predicted the dose proportionality of hydrochlorothiazide absorption . | NA | {
"id": "C0008273",
"name": "chlorothiazide",
"pos": [
48,
62
]
} | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
134,
153
]
} |
the lack of dose dependency in this case may be attributed to the higher solubility and pk alpha of hydrochlorothiazide compared with chlorothiazide . | NA | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
100,
119
]
} | {
"id": "C0008273",
"name": "chlorothiazide",
"pos": [
134,
148
]
} |
isosorbide 5-mononitrate and the internal standard ( isosorbide dinitrate ) are extracted from the alkalinized plasma with ether . | NA | {
"id": "C0064079",
"name": "isosorbide 5-mononitrate",
"pos": [
0,
24
]
} | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
53,
73
]
} |
the pharmacokinetics of isosorbide dinitrate ( isdn ) and its isomeric mononitrate metabolites ( 2- and 5-ismn ) were examined in the rat . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
24,
44
]
} | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
104,
110
]
} |
isdn was metabolized exclusively via its mononitrate metabolites , with the 5-ismn being the principal product ( about 90 % ) . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
0,
4
]
} | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
76,
82
]
} |
5-ismn did not affect isdn plasma clearance when these compounds were administered at different intravascular sites . | NA | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
0,
6
]
} | {
"id": "C0022252",
"name": "isdn",
"pos": [
22,
26
]
} |
however , when 5-ismn and isdn were given at the same vascular site , a decrease in plasma isdn clearance was observed . | NA | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
15,
21
]
} | {
"id": "C0022252",
"name": "isdn",
"pos": [
91,
95
]
} |
if angiotensins ii and iii act at the same receptors in the portal vein , angiotensin iii could inhibit the constricting action of angiotensin ii and thereby play a role in the angiotensin-mediated control of portal venous capacity . | NA | {
"id": "C0003012",
"name": "angiotensin iii",
"pos": [
74,
89
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
177,
188
]
} |
if angiotensins ii and iii act at the same receptors in the portal vein , angiotensin iii could inhibit the constricting action of angiotensin ii and thereby play a role in the angiotensin-mediated control of portal venous capacity . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
74,
88
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
177,
188
]
} |
comparative inhibition of pi-plc by other aminoglycosides ( at 1-2 mm concentrations ) approximates their known nephrotoxic potential : streptomycin less than or equal to kanamycin less than or equal to amikacin less than tobramycin less than gentamicin less than neomycin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
42,
57
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
136,
148
]
} |
comparative inhibition of pi-plc by other aminoglycosides ( at 1-2 mm concentrations ) approximates their known nephrotoxic potential : streptomycin less than or equal to kanamycin less than or equal to amikacin less than tobramycin less than gentamicin less than neomycin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
42,
57
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
243,
253
]
} |
comparative inhibition of pi-plc by other aminoglycosides ( at 1-2 mm concentrations ) approximates their known nephrotoxic potential : streptomycin less than or equal to kanamycin less than or equal to amikacin less than tobramycin less than gentamicin less than neomycin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
171,
180
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
203,
211
]
} |
extracellular single-cell recording and microiontophoretic techniques were used to characterize the presynaptic dopamine ( da ) receptors ( autoreceptors ) on a10 da neurons in the rat ventral tegmental area . | NA | {
"id": "C0206129",
"name": "presynaptic",
"pos": [
100,
111
]
} | {
"id": "C0206128",
"name": "autoreceptors",
"pos": [
140,
153
]
} |
an application of noradrenaline , adrenaline and isoproterenol each to the ganglion inhibited a twitch response of the vas deferens to preganglionic nerve stimulation at low frequencies . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
18,
31
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
34,
44
]
} |
the non-selective agonists noradrenaline , adrenaline and isoprenaline were also employed with various combinations of antagonists . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} |
amino acid analyses of plasma samples obtained after serine loading in patients and controls suggest that serine-responsive patients had an impaired conversion of glycine into serine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
163,
170
]
} |
these melanotropins possessed almost identical actions to [ nle4 , d-phe 7 ] - alpha-msh as determined by several melanocyte bioassays . | NA | {
"id": "C0026667",
"name": "melanotropins",
"pos": [
6,
19
]
} | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
79,
88
]
} |
however , several of the 8-substituted derivatives of 9- [ ( 2-hydroxyethoxy ) methyl ] guanine ( acyclovir ) had higher antiviral specificity in vitro than the parent drug . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
88,
95
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
98,
107
]
} |
three-day-old chicks did not develop enteritis after oral infection but chicks infected within 12 h of hatching developed gastroenteritis . | NA | {
"id": "C0014335",
"name": "enteritis",
"pos": [
37,
46
]
} | {
"id": "C0017160",
"name": "gastroenteritis",
"pos": [
122,
137
]
} |
the complement-mediated solubilization ( cms ) of immune complexes ( ic ) and the initial kinetics ( iks ) of this reaction in human sera depleted of or deficient in c2 , c3 , c8 , factors b , p and i were investigated . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
4,
14
]
} | {
"id": "C0033453",
"name": "factors b",
"pos": [
181,
190
]
} |
sera depleted of b or p and those lacking native c3 or factor i showed virtually no cms whereas the iks and cms capacity of a c8-deficient serum were within the reference range . | NA | {
"id": "C0009498",
"name": "cms",
"pos": [
84,
87
]
} | {
"id": "C0009525",
"name": "cms",
"pos": [
108,
111
]
} |
45ca2+ uptake was dependent on monovalent cations ( rb+ greater than k+ greater than na+ greater than li+ greater than choline+ ) and different anions ( cl- greater than br- greater than so4 ( 2- ) greater than no3- greater than i- greater than cyclamate- greater than scn- ) in both preparations . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
144,
150
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
292,
293
]
} |
the nucleosome spacing and apparent linker heterogeneity in the assembled nucleoprotein are very similar to those in chicken erythrocyte chromatin . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
74,
87
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
137,
146
]
} |
these complexes can be resolved into a linear dna molecule and a closed circular dna molecule , the end products of site-specific recombination . | NA | {
"id": "C0012854",
"name": "dna molecule",
"pos": [
46,
58
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
72,
84
]
} |
the externally dimorphic skin patches are closely associated with the internally dimorphic light organ system in seven species ( and possibly as many as ten ) , indicating a potential for light emission through the clear patches . | NA | {
"id": "C0991556",
"name": "skin patches",
"pos": [
25,
37
]
} | {
"id": "C0994894",
"name": "patches",
"pos": [
221,
228
]
} |
seven coumarin derivatives ( imperatorin , heraclenin , xanthotoxin , marmesin , chelepin , oxypeucedanin , esculin ) and a furan derivative ( nimbolide ) were screened on 6 ames tester strains ( ta92 , ta94 , ta97 , ta98 , ta100 , ta102 ) . | NA | {
"id": "C0010207",
"name": "coumarin derivatives",
"pos": [
6,
26
]
} | {
"id": "C0014839",
"name": "esculin",
"pos": [
108,
115
]
} |
evaluation of activated charcoal-sodium sulfate combination for inhibition of acetaminophen absorption and repletion of inorganic sulfate . | NA | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
33,
47
]
} | {
"id": "C0038720",
"name": "inorganic sulfate",
"pos": [
120,
137
]
} |
activated charcoal is an effective inhibitor of acetaminophen absorption while sodium sulfate can prevent the depletion of endogenous inorganic sulfate associated with the formation of acetaminophen sulfate . | NA | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
79,
93
]
} | {
"id": "C0038720",
"name": "inorganic sulfate",
"pos": [
134,
151
]
} |
the results confirm that activated charcoal can reduce acetaminophen absorption and show that oral administration of activated charcoal with sodium sulfate does not alter the inhibitory effect of activated charcoal on acetaminophen absorption or the bioavailability of the sulfate . | NA | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
141,
155
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
273,
280
]
} |
the transforming potential of dl250 was assayed on an established rat embryo fibroblast cell line , cref , and on primary rat embryo fibroblasts and baby rat kidney cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
133,
144
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
165,
170
]
} |
bovine papillomavirus type 1 ( bpv-1 ) or cloned bpv-1 dna can transform susceptible rodent cells , and the viral dna remains as a stable extrachromosomal plasmid in the transformed cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
55,
58
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
108,
117
]
} |
to define more precisely the viral dna sequences which are involved in cellular transformation , we have tested the ability of defined deletion mutants of bpv-1 dna to morphologically transform mouse c127 cells . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
29,
38
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
161,
164
]
} |
a fourth group of monoclonal antibodies precipitated a non-glycosylated polypeptide of 91,000 daltons and several smaller polypeptides , but these antibodies demonstrated only limited neutralizing activity . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
18,
39
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
147,
157
]
} |
to determine whether these acidic amino acids and tyrosine 315 are required to maintain the transforming activity of middle t antigen , we constructed deletions within the dna sequences encoding these amino acids and measured the capacity of the resulting mutants to transform rat-1 cells in culture . | NA | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
27,
45
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
201,
206
]
} |
the middle t antigen encoded by one of these mutants , ppdl1-4 , lacks part of the acidic string of amino acids but not tyrosine 315 ( amino acids 304 through 310 are deleted ) , whereas the middle t antigen encoded by the other mutant , ppdl2-7 , lacks the entire acidic amino acid stretch as well as tyrosine 315 ( amino acids 285 through 323 are deleted ) . | NA | {
"id": "C0815040",
"name": "acidic amino acid",
"pos": [
265,
282
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
317,
328
]
} |
cottontail rabbits ( sylvilagus floridanus ) were infected with herpesvirus sylvilagus , and spleen cells were analyzed for the presence of virus-specific , covalently closed circular , and linear dna molecules by a simple electrophoretic technique , followed by transfer to nitrocellulose filters and hybridization with cloned viral dna ( gardella et al. , j . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
197,
210
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
328,
337
]
} |
competition binding experiments have established the following relative affinities of icp8 for the following nucleic acids : single-stranded hsv-1 dna congruent to bacteriophage fd dna greater than polyriboadenylate much greater than double-stranded hsv-1 dna congruent to d ( pcpt ) 5 . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
109,
122
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
256,
259
]
} |
observation of negatively stained icp8-single-stranded dna complexes indicated that icp8 binds along the length of the dna in a regular repeating fashion . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
39,
54
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
119,
122
]
} |
the isolates were propagated in human diploid fibroblast ( mrc5 ) cells , and virus was released into the culture medium in the absence of overt cytolysis . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} |
fifteen to fifty percent of wild-type levels of viral dna are synthesized at the nonpermissive temperature in ts48- and ts303-infected cells , indicating that immediate-early and early gene functions are intact ( or nearly so ) and that the block in ts48 and ts303 is in a regulatory event subsequent to that exhibited by other mutants in complementation group 1-2 which are dna- . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
48,
57
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
375,
378
]
} |
twenty-four monoclonal antibodies were isolated with specificities for 13 different virus-specified polypeptides ( or complexes of polypeptides ) , including the major capsid protein of the virus ( 150k ) , the 160k and 130k structural proteins , a 108k structural phosphoprotein , structural glycoproteins , the nonstructural early 76k protein , early nonstructural dna-binding proteins of 48 to 51k and 110k and the major immediate-early protein of 52k . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
175,
182
]
} | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
367,
387
]
} |
these observations suggest the presence of epitopes common to virus and host proteins and an antigenic site common to an immediate-early and a delayed-early virus protein . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
43,
51
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
93,
102
]
} |
these observations suggest the presence of epitopes common to virus and host proteins and an antigenic site common to an immediate-early and a delayed-early virus protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
77,
85
]
} | {
"id": "C0042736",
"name": "virus protein",
"pos": [
157,
170
]
} |
the term ambisense rna is coined to describe this novel coding strategy of a viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
19,
22
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
77,
86
]
} |
the ribonucleotide reductase ( ribonucleoside-diphosphate reductase ; ec 1.17.4.1 ) induced by herpes simplex virus type 2 infection of serum-starved bhk-21 cells was purified to provide a preparation practically free of both eucaryotic ribonucleotide reductase and contaminating enzymes that could significantly deplete the substrates . | NA | {
"id": "C0035545",
"name": "ribonucleoside-diphosphate reductase",
"pos": [
31,
67
]
} | {
"id": "C0035547",
"name": "ribonucleotide reductase",
"pos": [
237,
261
]
} |
this situation is unlike that with sendai virus , a paramyxovirus , which has a nonstructural c protein encoded by a second overlapping reading frame near the 5 ' end of the mrna for phosphoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
96,
103
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
183,
197
]
} |
in a group of 11 monoclonal antibodies specifically reacting with the measles virus fusion protein , three antibodies also immunoprecipitated other proteins , in particular a 79,000-molecular-weight protein from virus-infected cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
17,
38
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} |
the attack rate in the general population ( excluding day-care attendees ) was highest in children younger than 1 year ( 131.9 cases per 100,000 per year ) and in those 1 to 2 years old ( 75.7 cases per 100,000 per year ) compared with older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
90,
98
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
236,
250
]
} |
three of the 14 patients had hyperinsulinemia as the result of excessive human insulin release and were found to have either intrinsic pancreatic disease or secretagogue-mediated insulin release . | NA | {
"id": "C0795635",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
179,
186
]
} |
before and after tpn fibronectin , albumin , prealbumin , transferrin , and two acute-phase reactants , haptoglobin and orosomucoid were measured in plasma . | NA | {
"id": "C0040679",
"name": "transferrin",
"pos": [
58,
69
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
80,
91
]
} |
before and after tpn fibronectin , albumin , prealbumin , transferrin , and two acute-phase reactants , haptoglobin and orosomucoid were measured in plasma . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
80,
91
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
104,
115
]
} |
before and after tpn fibronectin , albumin , prealbumin , transferrin , and two acute-phase reactants , haptoglobin and orosomucoid were measured in plasma . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
80,
91
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
120,
131
]
} |
from the results , it is assumed that the stimulation of ca2+ ( mg2+ ) -atpase [ ca2+-pump atpase ] activity induced by nitroglycerin and sin-1 a in the microsome of thoracic aorta takes part in the relaxation of contractile tension in the tissue . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
72,
78
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
81,
84
]
} |
comparative studies of ccl against cephalexin ( cex ) were conducted in 5 healthy volunteers with cross over method . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
23,
26
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
35,
45
]
} |
peak blood levels of ccl and cex were 14.8 micrograms/ml at 2 hours and 11.5 micrograms/ml at 3 hours , respectively . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
21,
24
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
29,
32
]
} |
in vitro antibacterial activities ( mic ) of ccl and cex were studied in 74 out of 81 strains ( 41 from aerobes and 40 from anaerobes ) isolated from 47 patients . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
45,
48
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
53,
56
]
} |
the following antibiotics were evaluated : cephalexin ( cex ) , cephalothin ( cet ) , cefazolin ( cez ) , cefotiam ( ctm ) , cefoxitin ( cfx ) , cefmetazole ( cmz ) , cefotaxime ( ctx ) , cefoperazone ( cpz ) , ceftizoxime ( czx ) , cefmenoxime ( cmx ) and latamoxef ( lmox ) . | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
106,
114
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
167,
177
]
} |
the following antibiotics were evaluated : cephalexin ( cex ) , cephalothin ( cet ) , cefazolin ( cez ) , cefotiam ( ctm ) , cefoxitin ( cfx ) , cefmetazole ( cmz ) , cefotaxime ( ctx ) , cefoperazone ( cpz ) , ceftizoxime ( czx ) , cefmenoxime ( cmx ) and latamoxef ( lmox ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
167,
177
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
211,
222
]
} |
the following antibiotics were evaluated : cephalexin ( cex ) , cephalothin ( cet ) , cefazolin ( cez ) , cefotiam ( ctm ) , cefoxitin ( cfx ) , cefmetazole ( cmz ) , cefotaxime ( ctx ) , cefoperazone ( cpz ) , ceftizoxime ( czx ) , cefmenoxime ( cmx ) and latamoxef ( lmox ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
167,
177
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
233,
244
]
} |
s. aureus : susceptible strains to cet , cez , ctm , cfx and cmz with mic less than 15 micrograms/ml accounted for 93 , 75 , 93 , 70 and 96 % of the strains tested , while those to ctx , cpz , czx , cmx and lmox for 89 , 65 , 61 , 86 and 62 % , respectively . | NA | {
"id": "C0007556",
"name": "ctm",
"pos": [
47,
50
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
181,
184
]
} |
s. aureus : susceptible strains to cet , cez , ctm , cfx and cmz with mic less than 15 micrograms/ml accounted for 93 , 75 , 93 , 70 and 96 % of the strains tested , while those to ctx , cpz , czx , cmx and lmox for 89 , 65 , 61 , 86 and 62 % , respectively . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
181,
184
]
} | {
"id": "C0007560",
"name": "czx",
"pos": [
193,
196
]
} |
s. aureus : susceptible strains to cet , cez , ctm , cfx and cmz with mic less than 15 micrograms/ml accounted for 93 , 75 , 93 , 70 and 96 % of the strains tested , while those to ctx , cpz , czx , cmx and lmox for 89 , 65 , 61 , 86 and 62 % , respectively . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
181,
184
]
} | {
"id": "C0007549",
"name": "cmx",
"pos": [
199,
202
]
} |
s. pyogenes : all strains studied were susceptible to cet , ctx , cpz , czx , cmx and lmox at mics less than or equal to 15 micrograms/ml . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
60,
63
]
} | {
"id": "C0007560",
"name": "czx",
"pos": [
72,
75
]
} |
s. pyogenes : all strains studied were susceptible to cet , ctx , cpz , czx , cmx and lmox at mics less than or equal to 15 micrograms/ml . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
60,
63
]
} | {
"id": "C0007549",
"name": "cmx",
"pos": [
78,
81
]
} |
strains of e. coli susceptible to cet , cez , ctm , cfx and cmz at mics less than or equal to 15 micrograms/ml were 78 to 96 % , while those to ctx , cpz , czx , cmx and lmox were 94 to 100 % . | NA | {
"id": "C0007556",
"name": "ctm",
"pos": [
46,
49
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
144,
147
]
} |
strains of e. coli susceptible to cet , cez , ctm , cfx and cmz at mics less than or equal to 15 micrograms/ml were 78 to 96 % , while those to ctx , cpz , czx , cmx and lmox were 94 to 100 % . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
144,
147
]
} | {
"id": "C0007560",
"name": "czx",
"pos": [
156,
159
]
} |
strains of e. coli susceptible to cet , cez , ctm , cfx and cmz at mics less than or equal to 15 micrograms/ml were 78 to 96 % , while those to ctx , cpz , czx , cmx and lmox were 94 to 100 % . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
144,
147
]
} | {
"id": "C0007549",
"name": "cmx",
"pos": [
162,
165
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
64,
74
]
} | {
"id": "C0007550",
"name": "cefmetazole",
"pos": [
132,
143
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
64,
74
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
154,
163
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
166,
176
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
179,
190
]
} |
the in vivo activity of cefodizime ( hr 221 ) was compared with that of cefotaxime ( ctx ) , cefmenoxime , latamoxef , cefazolin and cefmetazole ( cmz ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
72,
82
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
93,
104
]
} |
[ diagnostic efficacy of computed tomography and radionuclide imaging on detecting sol of liver disease and liver cirrhosis ] . | NA | {
"id": "C0023895",
"name": "of liver disease",
"pos": [
87,
103
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
108,
123
]
} |
adding norepinephrine or epinephrine to the perfusate raised the perfusion pressure , increased the flow along the internal carotid branch , and decreased it in the external carotid branch in the blood-perfused experiments but not in the saline-perfused ones . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
7,
21
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} |
controlled bleeding of the support dog ( at the rate of 4 ml/ ( kg x min ] produced a similar result to that produced by exogenous norepinephrine or epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
131,
145
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
149,
160
]
} |
the data obtained demonstrated that urea , glycerol , ethanol , and methanol induced a rapid volume increase , whereas glucose and galactose induced a slow volume increase . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
54,
61
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
68,
76
]
} |
[ value of the anamnesis , exertion electrocardiogram and perfusion scintigraphy in the diagnosis of ischemic heart disease in patients after myocardial infarct or revascularization ] . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
11,
14
]
} | {
"id": "C0027051",
"name": "myocardial infarct",
"pos": [
142,
160
]
} |
simultaneously , the glucose tolerance test was carried out and blood concentrations of cholesterol , triglycerides , high density lipoprotein cholesterol , fibrinogen and disoluble fibrin were determined . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
88,
99
]
} | {
"id": "C0023822",
"name": "high density",
"pos": [
118,
130
]
} |
other reasons are congenital abnormalities like a cervical rib , an abnormal first rib , acquired anatomic lesions like fractures and traumata or functional factors . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
120,
129
]
} | {
"id": "C0043251",
"name": "traumata",
"pos": [
134,
142
]
} |
beta-blocker induced changes in the cholesterol : high-density lipoprotein cholesterol ratio and risk of coronary heart disease . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
36,
47
]
} | {
"id": "C0023822",
"name": "high-density lipoprotein",
"pos": [
50,
74
]
} |
comparison of plasma lipoprotein concentrations in hypertensive patients treated with commonly used beta-blockers with lipoprotein concentrations in patients with coronary heart disease shows that these drugs cause clinically important shifts in the cholesterol ratio [ total cholesterol ( tc ) : high-density lipoprotein cholesterol ( hdlc ) ] and reductions in the atheroprotective lipoprotein hdlc . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
250,
261
]
} | {
"id": "C0023822",
"name": "lipoprotein hdlc",
"pos": [
384,
400
]
} |
plasma lipoprotein measurements at 3-6 month intervals seem mandatory in patients with cholesterol values greater than 6 mmol/1 ( 230 mg/dl ) and ( tc ) : hdlc ratios above 5 at the start of treatment . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
87,
98
]
} | {
"id": "C0023822",
"name": "hdlc",
"pos": [
155,
159
]
} |
to analyse the role of the renin angiotensin system in the pathogenesis of hypertension in cushing 's syndrome ten patients with hypercorticism ( five with pituitary hypothalamic dysfunction , three with adrenal adenomas and two with adrenal carcinomas ) received a single oral dose of 25 mg captopril . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
91,
110
]
} | {
"id": "C0001622",
"name": "hypercorticism",
"pos": [
129,
143
]
} |
neither organification of iodine , nor any subsequent step of thyroid hormone biosynthesis ( transformation of monoiodotyrosine to diiodotyrosine and then to thyroxine ) were affected . | NA | {
"id": "C0040135",
"name": "thyroid hormone",
"pos": [
62,
77
]
} | {
"id": "C0021996",
"name": "monoiodotyrosine",
"pos": [
111,
127
]
} |
neither organification of iodine , nor any subsequent step of thyroid hormone biosynthesis ( transformation of monoiodotyrosine to diiodotyrosine and then to thyroxine ) were affected . | NA | {
"id": "C0040135",
"name": "thyroid hormone",
"pos": [
62,
77
]
} | {
"id": "C0012344",
"name": "diiodotyrosine",
"pos": [
131,
145
]
} |
we evaluated changes of advanced liver disease and hepatic encephalopathy on the concentrations of amino acids ( aa ) and ammonia in plasma and cerebrospinal fluid ( csf ) and of the neurotransmitters norepinephrine , dopamine and 5-hydroxytryptamine ( 5-ht ) as well as the 5-hydroxyindole acetic acid ( 5-hiaa ) in csf before and at the end of a 3-day period of treatment with infusions enriched with branched chain amino acids ( bcaa ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
99,
110
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
403,
429
]
} |
in our sig- nm cases , the neoplastic nodules consistently expressed b1 and ia-like antigens and lacked t cells , indicating a b cell neoplasm similar to many large cell lymphomas . | NA | {
"id": "C0079731",
"name": "b cell neoplasm",
"pos": [
127,
142
]
} | {
"id": "C0079744",
"name": "large",
"pos": [
159,
164
]
} |
hypertriglyceridemia and its relation to tissue lipoprotein lipase activity in endotoxemic , escherichia coli bacteremic , and polymicrobial septic rats . | NA | {
"id": "C0376618",
"name": "endotoxemic",
"pos": [
79,
90
]
} | {
"id": "C0004610",
"name": "bacteremic",
"pos": [
110,
120
]
} |
in contrast to endotoxemic and e. coli bacteremic rats , polymicrobial peritonitis resulted in significant increases in heart ( 46-89 % ) and skeletal muscle ( 18-39 % ) lipoprotein lipase activity . | NA | {
"id": "C0376618",
"name": "endotoxemic",
"pos": [
15,
26
]
} | {
"id": "C0004610",
"name": "bacteremic",
"pos": [
39,
49
]
} |
thus , hypertriglyceridemia is not necessarily a consequence of sepsis but occurred in endotoxemic and bacteremic states when muscle and adipose tissue lipoprotein lipase activities were reduced . | NA | {
"id": "C0376618",
"name": "endotoxemic",
"pos": [
87,
98
]
} | {
"id": "C0004610",
"name": "bacteremic",
"pos": [
103,
113
]
} |
therefore , we intend in this study to observe the effects of prostaglandin f2 alpha and prostaglandin e2 and the interactions between epinephrine , a potent lhrh agonist [ ( d-ser- ( tbu ) 6 , des-gly-nh10 ( 2 ) lhrh ethylamide : buserelin ] and hcg in normal and in vitro hcg-desensitized rat immature luteal cells in monolayer culture , on basal , hcg or cholera toxin stimulated intracellular and extracellular camp and progesterone secretion . | NA | {
"id": "C0023610",
"name": "lhrh",
"pos": [
158,
162
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
231,
240
]
} |
in the presence of trilostane , added to the cells in order to block the conversion of pregnenolone to cortisol , the net maximal output of pregnenolone and 17-hydroxypregnenolone in response to acth was significantly increased in adrenocortical cells from acth-treated animals ( 449.5 +/- 35.8 ng pregnenolone and 85.7 +/- 10.5 ng 17-hydroxypregnenolone vs 269.1 +/- 36.3 ng pregnenolone and 43.7 +/- 8.51 ng 17-hydroxypregnenolone for cells from control guinea-pigs ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
87,
99
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
410,
432
]
} |
it appeared therefore that the total production of pregnenolone ( as estimated by the sum of pregnenolone and 17-hydroxypregnenolone produced by the cells incubated with trilostane ) nearly reached the level of the maximal production of cortisol in response to acth and was also significantly enhanced for cells from acth-treated animals ( 532.2 +/- 38.4 ng vs 312.8 +/- 40.0 ng for cells from control group ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
51,
63
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
110,
132
]
} |
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