text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the dose response for ct , heat-labile enterotoxin , and ct plus estrogen plus progesterone was most linear ( r greater than 0.93 ) when the logarithm of uterine weight was plotted against the dose of toxin . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
39,
50
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
201,
206
]
} |
the mics of cephalothin , cefamandole , and cefoperazone were not substantially influenced by the type of culture medium used . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
26,
37
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
44,
56
]
} |
in contrast , mics of cefuroxime , ceftizoxime , cefotaxime , cefmenoxime , and ceftriaxone varied markedly with both the commercial brand and the blood content of the broth used . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
22,
32
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
49,
59
]
} |
in contrast , mics of cefuroxime , ceftizoxime , cefotaxime , cefmenoxime , and ceftriaxone varied markedly with both the commercial brand and the blood content of the broth used . | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
35,
46
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
49,
59
]
} |
in contrast , mics of cefuroxime , ceftizoxime , cefotaxime , cefmenoxime , and ceftriaxone varied markedly with both the commercial brand and the blood content of the broth used . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
49,
59
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
62,
73
]
} |
in contrast , mics of cefuroxime , ceftizoxime , cefotaxime , cefmenoxime , and ceftriaxone varied markedly with both the commercial brand and the blood content of the broth used . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
49,
59
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
80,
91
]
} |
differential detection of cholera enterotoxin and escherichia coli heat-labile enterotoxin by enzyme-linked immunosorbent assays with antibodies specific to the two toxins . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
34,
45
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
165,
171
]
} |
bone marrow fibroblasts could be infected with varicella-zoster virus , and these infected cells were suitable targets for a 51cr-release cytotoxicity assay . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
12,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} |
monoclonal antibodies were used as a primary antibody source in a solid-phase immunoblot assay system . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
45,
53
]
} |
of 13 monoclonal antibodies examined , 3 were able to detect 10 ( 3 ) virulent treponemes , and 1 of these antibodies was able to reveal the presence of as few as 500 organisms . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
6,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} |
neither noxythiolin nor its degradation products ( n-methylthiourea and formaldehyde ) were absorbed by the plastic ( polypropylene ) containers used . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
108,
115
]
} | {
"id": "C0032582",
"name": "polypropylene",
"pos": [
118,
131
]
} |
therefore , noxythiolin solutions can be stored in certain plastic ( polypropylene ) containers under the same conditions as recommended for glass bottles . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
59,
66
]
} | {
"id": "C0032582",
"name": "polypropylene",
"pos": [
69,
82
]
} |
to evaluate the rat as an experimental model for plasminogen activator research , the ability of antibodies specific for human tissue type plasminogen activator and urokinase to suppress the plasminogen activator activity in whole plasma and in the vessel wall was studied in both rat and man . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
49,
70
]
} | {
"id": "C0032143",
"name": "tissue type plasminogen activator",
"pos": [
127,
160
]
} |
in rat plasma the inhibitory effect on the fibrinolytic activity was seen only with high concentrations of antibodies against melanoma cell activator , which suggests that rat plasminogen activator in plasma and vessel walls is similar to , but not identical with , human tissue type plasminogen activator . | NA | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
176,
187
]
} | {
"id": "C0032143",
"name": "tissue type plasminogen activator",
"pos": [
272,
305
]
} |
concanavalin a ( con a ) is a plant-derived lectin that has the capability of agglutinating malignant cells in vitro . | NA | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
0,
14
]
} | {
"id": "C0304052",
"name": "plant",
"pos": [
30,
35
]
} |
synthesis of milk protein increased during postruminal infusions of protein as indicated by the increased casein nitrogen fraction in milk . | NA | {
"id": "C0026138",
"name": "milk protein",
"pos": [
13,
25
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
106,
112
]
} |
local and systemic corticoid hormones , dapsone , and periodontal therapy have all been used with variable success to treat the disease . | NA | {
"id": "C0001617",
"name": "corticoid",
"pos": [
19,
28
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
29,
37
]
} |
type i reactions are generally immunoglobulin ( ig ) e-mediated , and clinical manifestations include urticaria , angioedema , respiratory symptoms , and anaphylaxis . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
102,
111
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
114,
124
]
} |
anaphylactoid reactions mimic immunoglobulin e-mediated hypersensitivity in that signs may consist of urticaria , angioedema , wheezing , dyspnea , hypotension , or shock . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
102,
111
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
114,
124
]
} |
abnormalities in the complement system or an increased conversion of prekallikrein to kallikrein has been demonstrated in some patients who have had anaphylactoid reactions . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
69,
82
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
86,
96
]
} |
two patients with systemic allergic reactions to animal insulin have at least as much cutaneous reactivity and ige and igg antibodies to hi as to porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
56,
63
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
146,
161
]
} |
erythrocytic thiols , both non-protein and protein-bound , were depleted in the presence of sporidesmin , whilst haemoglobin was oxidized to methaemoglobin . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
113,
124
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
141,
155
]
} |
chromatofocusing , a form of ion-exchange chromatography in which proteins are separated on the basis of their differing isoelectric points , has been adapted for use with membrane proteins , solubilized by the non-ionic detergent nonidet p-40 . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
66,
74
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
172,
189
]
} |
sixty biomicroscopically normal corneas were obtained from cadavers ( 50-70 years ) within six hours after death . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
59,
67
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
107,
112
]
} |
eight patients had associated fractures or dislocations of the ipsilateral extremity : elbow fracture or dislocation ( three patients ) , shoulder fracture ( one patient ) , fractured humerus ( two patients ) , and phalangeal fractures ( three patients ) . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
30,
39
]
} | {
"id": "C0037006",
"name": "shoulder fracture",
"pos": [
138,
155
]
} |
preiser 's disease , or avascular necrosis of the scaphoid , is an exceedingly rare although debilitating pathologic process . | NA | {
"id": "C0012634",
"name": "disease",
"pos": [
11,
18
]
} | {
"id": "C0030660",
"name": "pathologic process",
"pos": [
106,
124
]
} |
the peroxidase-labeled antigen method was used to localize these proteins , as well as immunoglobulins , light chains , and albumin , in bouin-fixed , paraffin-embedded sections of 24 normal term placentas . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
65,
73
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
124,
131
]
} |
it is argued that the same criteria that led to the removal of homosexuality per se as a mental disorder require the removal of all the paraphilias per se , there is no empirical warrant to justify their continued inclusion , and while there is legitimacy for a generalized ego-dystonic category , such ego-dystonias are only incidentally sexual . | NA | {
"id": "C0004936",
"name": "mental disorder",
"pos": [
89,
104
]
} | {
"id": "C0030482",
"name": "paraphilias",
"pos": [
136,
147
]
} |
inhibition of t cell functions by antigen-specific antibodies appeared to correlate with the antibody-antigen binding constant because a second monoclonal antibody ( cyt-1-59 ) , with identical specificity but with a lower affinity constant for apo-cytochrome c , had very little inhibitory effect on the proliferation or lymphokine secretion of apo-cytochrome c-specific t cell clones . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
144,
154
]
} |
treatment of 5fubm ( bdf1 mice ) before suspension culture with a high concentration of either of two cytotoxic monoclonal antibodies directed against the thy-1.2 surface antigen in the presence of rabbit complement reduced or abrogated the generation of stem cells hpp-cfc and gm-cfu-c in suspension cultures , even though the input content of hpp-cfc and gm-cfu-c in treated 5fubm compared with control 5fubm showed little reduction by the antibody plus complement treatment . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
112,
122
]
} | {
"id": "C0003241",
"name": "little",
"pos": [
418,
424
]
} |
stringent accessory cell ( ac ) depletion by a three-step procedure -- plastic adherence , nylon wool adherence , followed by simultaneous treatment with two anti-ac monoclonal antibodies + complement -- has allowed the demonstration of several ac-dependent stages in the t cell activation pathway . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
71,
78
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
91,
96
]
} |
a monoclonal anti-tac antibody has been identified as a putative antibody against the human interleukin 2 ( il 2 ) receptor . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
2,
12
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
65,
73
]
} |
in addition , these antibodies together with four previously reported glycophorin monoclonal antibodies , including two that specifically recognize the m form of glycophorin a , were tested for binding to mcm and mken ( uk ) variant human erythrocytes and m- and mnv-type chimpanzee erythrocytes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
20,
30
]
} | {
"id": "C0003250",
"name": "antibodies",
"pos": [
93,
103
]
} |
the production of thick coats of gag by glioma cells was induced by interaction of glioma cells with a nondialyzable factor produced by pbmc in culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
136,
140
]
} |
the formation of thick , protective gag coats by glioma cells as a result of their interaction with the pbmc-derived factor constitutes a nonspecific suppressor mechanism that may contribute to the ability of this class of human solid tumors to evade cellular immune attack . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
104,
108
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
251,
259
]
} |
the cytoskeleton , with particular emphasis on filamentous actin ( f-actin ) , was studied in target l cells treated with the cytotoxic lymphokine , alpha-lymphotoxin ( lt ) , or with cytotoxic t lymphocytes . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
136,
146
]
} | {
"id": "C0024320",
"name": "alpha-lymphotoxin",
"pos": [
149,
166
]
} |
the amount of protein ( as radiolabelled albumin ) actually bound to either type of disc or microtitre trays was similar , and low ( 5 % of the protein applied for each media ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
41,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
144,
151
]
} |
the ability of the mononuclear phagocyte-specific colony-stimulating factor , csf-1 , to down-regulate its receptor on peritoneal exudate macrophages ( pem ) was examined . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
50,
75
]
} | {
"id": "C0079784",
"name": "csf-1",
"pos": [
78,
83
]
} |
this assay offers significantly improved specificity compared to previous immunoconglutinin ( ik ) assays in that it not only defines the isotype and antigenic specificity of the ik but also eliminates false positive results associated with immune complexes or aggregated human gamma globulin , or with natural antibodies directed at heterologous reagents . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
138,
145
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
311,
321
]
} |
this assay offers significantly improved specificity compared to previous immunoconglutinin ( ik ) assays in that it not only defines the isotype and antigenic specificity of the ik but also eliminates false positive results associated with immune complexes or aggregated human gamma globulin , or with natural antibodies directed at heterologous reagents . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
241,
257
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
311,
321
]
} |
as the main brush-border proteins are glycosylated and share common lectin reactivities , it is possible that these antibodies are directed against carbohydrate antigens . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
25,
33
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
68,
74
]
} |
varying concentrations of purified antigen and of samples containing unknown amounts of antigen were then mixed with the limiting concentration of monoclonal antibody , prior to or at the same time as the reaction of the antibody with the surface-adsorbed antigen . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
147,
166
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
221,
229
]
} |
the amount of monoclonal antibody that bound to the surface-adsorbed antigen was determined with a second antibody , radioactive goat anti-mouse antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
14,
33
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
145,
153
]
} |
the addition of the free antigen preparations to the monoclonal antibody served to compete for the antibody with the antigen adsorbed to the plastic surfaces . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
53,
72
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
99,
107
]
} |
re-evaluation of the factors ( e.g . ficoll concentration , temperature , and ratio of the diatrizoate salts ) which affect these separations showed that under our conditions it was advantageous to use a medium with a lower viscosity ( ficoll concentration ) and/or a higher osmotic strength ( increased sodium diatrizoate : meglumine diatrizoate ) than had been recommended previously ( ferrante and thong , 1978 ; 1980 ; ferrante et al. , 1982 ) . | NA | {
"id": "C0012004",
"name": "diatrizoate",
"pos": [
91,
102
]
} | {
"id": "C0012005",
"name": "meglumine diatrizoate",
"pos": [
325,
346
]
} |
analysis of aminoglycoside-resistant enterobacteriaceae isolated from patients at the seattle veterans administration medical center indicated that a single 68-kilobase r factor was responsible for the epidemic spread of low-level resistance to gentamicin , kanamycin , and tobramycin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
12,
26
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
245,
255
]
} |
lipoprotein fractions ( very low density lipoprotein : vldl , low density lipoprotein : ldl , high density lipoprotein : hdl , and very high density lipoprotein : vhdl ) were prepared by the method of ultracentrifugation . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
0,
11
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
24,
40
]
} |
brain ammonia and methanethiol concentrations in normal rats receiving 0.75 mmol nh+4 plus 0.15 mmol octanoic acid plus 18 mumol methanethiol were comparable with those observed in 24 rats in hepatic coma after fulminant hepatic failure caused by acute massive ischemic liver necrosis . | NA | {
"id": "C0162557",
"name": "hepatic",
"pos": [
192,
199
]
} | {
"id": "C0001364",
"name": "acute",
"pos": [
247,
252
]
} |
although imidoesters are routinely used at alkaline ph , we found that reaction of red blood cells with dimethyl adipimidate at ph 8.4 shortened the survival of rat red blood cells and impaired the deformability of human red blood cells . | NA | {
"id": "C0020929",
"name": "imidoesters",
"pos": [
9,
20
]
} | {
"id": "C0012398",
"name": "dimethyl adipimidate",
"pos": [
104,
124
]
} |
this fraction was composed of some different and discrete lipoprotein populations : intermediate-density lipoproteins ( in three of six patients , density = 1.006 to 1.019 gm/ml ) ; | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
58,
69
]
} | {
"id": "C0065063",
"name": "intermediate-density",
"pos": [
84,
104
]
} |
above its cmc , triton wr-1339 in concentrations between 2 and 10 mg/ml induced concentration-dependent structural changes in hdl which were characterized by a progressive displacement of apoa-i from the hdl surface without loss of lipids . | NA | {
"id": "C0023820",
"name": "hdl",
"pos": [
126,
129
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
232,
238
]
} |
only 4.3 % was transferred from chylomicrons to other lipoprotein classes during in vitro incubation for 5 hr . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
32,
44
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
54,
65
]
} |
the two monoclonal antibodies binding the ldl of more species were those antibodies which also inhibited the binding to and degradation of ldl by human fibroblasts . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
8,
29
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
73,
83
]
} |
the specific activities of 3h and of 14c fatty acids in triglyceride of the perfusate were greater than those of liver triglyceride , indicating preferential secretion of triglyceride produced from both de novo fatty acid synthesis and from infused free fatty acid substrate . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
41,
52
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
249,
264
]
} |
high degrees of covalent coupling have been obtained and the method has been used to purify antisulfoglycolipid antibodies from immune serum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
112,
122
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
128,
140
]
} |
the basic and acidic minor isoproteins differed by +2 , +1 , and -1 charges from the major apoa-i isoprotein designated apoa-i2 . | NA | {
"id": "C0085201",
"name": "1",
"pos": [
57,
58
]
} | {
"id": "C0003592",
"name": "apoa",
"pos": [
120,
124
]
} |
the apoa-i synthesized by organ cultures of cynomolgus monkey intestine and liver overlaps on the two-dimensional system with the corresponding most basic minor plasma apoa-i isoprotein designated apoa-i2 . | NA | {
"id": "C0085201",
"name": "apoa-i",
"pos": [
4,
10
]
} | {
"id": "C0003592",
"name": "apoa",
"pos": [
197,
201
]
} |
the action of a bacterial acyltransferase similar in overall reaction mechanism to the plasma enzyme lecithin : cholesterol acyltransferase ( lcat ) has been studied using normal plasma and lipoproteins and plasma from lcat-deficient patients . | NA | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
26,
41
]
} | {
"id": "C0023194",
"name": "lcat",
"pos": [
219,
223
]
} |
although considerable interconversion of radiolabeled cholesterol and cholesteryl ester could be demonstrated upon treatment of normal plasma or lipoproteins with the enzyme , there was little change in the actual amount of either steroid . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
54,
65
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
70,
87
]
} |
the relative proportions of cholesterol and cholesteryl ester in normal plasma are therefore near the equilibrium ratio for the reaction carried out by gcat , or the ratio is controlled by the properties of the lipoproteins themselves . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
28,
39
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
44,
61
]
} |
during reaction with the microbial acyltransferase , the ratio of cholesterol to cholesteryl ester in plasma from lcat-deficient patients was reduced substantially , suggesting that the enzyme may have some practical applications . | NA | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
35,
50
]
} | {
"id": "C0023194",
"name": "lcat",
"pos": [
114,
118
]
} |
during reaction with the microbial acyltransferase , the ratio of cholesterol to cholesteryl ester in plasma from lcat-deficient patients was reduced substantially , suggesting that the enzyme may have some practical applications . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
66,
77
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
81,
98
]
} |
patient 125i-labeled hdl was also taken up and degraded by the fibroblasts , apparently through the ldl-receptor pathway , stimulated cellular cholesterol esterification , increased cell cholesteryl ester content , and suppressed cholesterol synthesis and receptor activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
182,
186
]
} |
using a viable chondrocyte suspension prepared from dog epiphysial cartilage , specific steroid binding in the cells could be demonstrated for [ 3h ] dexamethasone but not 17 alpha-methyltrienolone , oestradiol-17 beta or 1 alpha , 25-dihydroxycholecalciferol . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} |
the actions of partially purified porcine platelet-derived growth factor ( pdgf ) and highly purified multiplication-stimulating activity ( msa ) ii and msa iii-2 , which are somatomedins , were investigated on the incorporation of [ 3h ] thymidine and [ 35s ] sulphate by fetal rat costal cartilage in vitro . | NA | {
"id": "C0021666",
"name": "msa",
"pos": [
140,
143
]
} | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
175,
187
]
} |
the correlation of noradrenaline and adrenaline plasma concentrations determined by the two methods were , respectively , r = 0.95 ( p less than 0.001 ) and r = 0.75 ( p less than 0.01 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
19,
32
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
37,
47
]
} |
plasma concentrations of epinephrine , norepinephrine , dopamine and cortisol were determined in four healthy volunteers -- resting completely in bed -- before and after food intake . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
39,
53
]
} |
a monoclonal antibody to guanine nucleotide binding protein inhibits the light-activated cyclic gmp pathway in frog rod outer segments . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
25,
43
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
96,
99
]
} |
sixteen monoclonal antibodies that reacted with the envelope glycoprotein ( e ) of 17d vaccine strain yellow fever virus ( 17d yf ) , including two antibodies produced against dengue 2 virus , were used in a solid phase competitive binding assay ( cba ) to define spatial relationships among antigenic determinants on 17d yf e . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
8,
29
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
148,
158
]
} |
analysis of the viral proteins indicated that proteins characteristic of both type c and type b retroviruses were present . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
16,
30
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
46,
54
]
} |
igm antibodies in sera from patients with chronic active hepatitis reacting with the measles virus matrix protein and nucleoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
106,
113
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
118,
131
]
} |
rabbit antisera produced against viral envelope glycoproteins showed heterologous antibody responses between parainfluenza 1 and 3 antibodies and between parainfluenza 1 and mumps antibodies by hai , eia , and immunoprecipitation . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
180,
190
]
} |
1-octanol/water partition coefficients , [ hgii ] octanol/ [ hgii ] water , provide a simple but limited model system for aspects of the biological behavior of methylmercury ( ii ) and commonly used organomercury ( ii ) medicinal compounds . | NA | {
"id": "C0044551",
"name": "1-octanol",
"pos": [
0,
9
]
} | {
"id": "C0001979",
"name": "octanol",
"pos": [
50,
57
]
} |
the guanine nucleotides gtp and guanyl-5'-imido-diphosphate [ gpp ( nh ) p ] , as well as divalent cations , modulate the proportion of the sites with high affinity for agonists as evidenced by their ability to shift the agonist competition curves for [ 3h ] ketanserin-labelled s2 receptors . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
4,
23
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
24,
27
]
} |
the guanine nucleotides gtp and guanyl-5'-imido-diphosphate [ gpp ( nh ) p ] , as well as divalent cations , modulate the proportion of the sites with high affinity for agonists as evidenced by their ability to shift the agonist competition curves for [ 3h ] ketanserin-labelled s2 receptors . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
24,
27
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
62,
74
]
} |
gtp and gpp ( nh ) p effects appear to be agonist-specific , as they do not affect antagonist competition for [ 3h ] ketanserin-labelled s2 receptors , or [ 3h ] ketanserin binding to s2 receptors . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
8,
20
]
} |
tryptic peptide maps of mbp phosphorylated by pl-ca-pk or a-pk , however , revealed different phosphopeptides , suggesting a difference in the intramolecular substrate specificity for the two enzymes . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
8,
15
]
} | {
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
94,
109
]
} |
the 2de profiles of csf and serum proteins were similar and indicated that a relatively nonselective filtration mechanism based on protein size is the major determinant for the overall pattern of csf proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
34,
41
]
} | {
"id": "C0007810",
"name": "csf",
"pos": [
196,
199
]
} |
the s-100 protein release was also enhanced by isoproterenol , norepinephrine , acth , and dibutyryl cyclic amp , which all increase the lipolysis by increasing cyclic amp levels in the tissue . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
91,
111
]
} | {
"id": "C0001455",
"name": "cyclic",
"pos": [
161,
167
]
} |
studies on the bovine brain pyruvate dehydrogenase complex using the antibodies against kidney enzyme complex . | NA | {
"id": "C0034344",
"name": "pyruvate dehydrogenase complex",
"pos": [
28,
58
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
95,
109
]
} |
to test whether there exist brain isozymes of pdhc differing from kidney enzyme , which has been extensively characterized , the pdhcs in bovine brain and kidney were compared using this anti-pdhc . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
34,
42
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
73,
79
]
} |
these pdhc peptides from kidney and brain were further compared by their peptide fragment patterns , which were generated by partial proteolysis with staphylococcus aureus v8 protease or by cnbr and resolved by sds-page . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
11,
19
]
} | {
"id": "C0030935",
"name": "peptide fragment",
"pos": [
73,
89
]
} |
samples of the perfusate representing the extracellular fluid were collected over 5-min periods and subsequently analyzed for contents of the amino acids glutamate , aspartate , glutamine , taurine , alanine , and serine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
142,
153
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
200,
207
]
} |
the effect of aliphatic aldehydes was specific in that the aliphatic alcohol , hexadecanol , or the short-chain aldehydes , acetaldehyde or butyraldehyde , did not promote myelin basic protein-induced vesicle aggregation . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
24,
33
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
124,
136
]
} |
immunoprecipitation of cell-free products with specific antisera localized the biosynthesis of the subunits of tyrosine hydroxylase ( th ) ( apparent mr = 61,000 ) and of phenylethanolamine n-methyltransferase ( pnmt ) ( apparent mr = 32,000 ) on free polysomes , compared with biosynthesis of subunits of dopamine beta-hydroxylase ( dbh ) ( apparent mr = 67,000 ) on membrane-bound polysomes . | NA | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
120,
131
]
} | {
"id": "C0013032",
"name": "dopamine beta-hydroxylase",
"pos": [
306,
331
]
} |
this inhibitory effect of gaba could be blocked by 120 microm bicuculline and mimicked by 50 microm muscimol or 150 microm thip whereas 150 microm ( - ) -baclofen had no effect . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
26,
30
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
154,
162
]
} |
norepinephrine ( ne ) and the selective alpha1-adrenoceptor agonist phenylephrine ( pe ) both markedly stimulate the formation of [ 3h ] inositol phosphates in a concentration-dependent manner upon incubation with [ 3h ] myo-inositol . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
137,
156
]
} | {
"id": "C0021547",
"name": "myo-inositol",
"pos": [
221,
233
]
} |
muscle tissue from 2 different biopsy samples from each subject were analyzed for enzymes representative of the citric acid cycle ( succinic dehydrogenase , sdh ) , beta-oxidation of fatty acids ( 3-hydroxyacyl coa dehydrogenase , had ) , glycogenolysis ( phosphorylase , phosph ) , glycolysis ( pyruvate kinase , pk ; phosphofructokinase , pfk and lactate dehydrogenase , ldh ) and glucose phosphorylation ( hexokinase , hk ) . | NA | {
"id": "C0038615",
"name": "succinic dehydrogenase",
"pos": [
132,
154
]
} | {
"id": "C0283592",
"name": "sdh",
"pos": [
157,
160
]
} |
a highly sensitive sandwich enzyme-immunoassay ( eia ) for human muscle carbonic anhydrase isozyme iii ( ca-iii ) has been developed using microplate as a solid-phase and peroxidase as a labelled enzyme . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
91,
98
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
196,
202
]
} |
rbc putrescine ( p less than .001 ) , spermidine ( p less than .01 ) , and spermine ( p less than .005 ) levels , and the putrescine-spermidine ratio ( p less than .001 ) increased in the cancer group while no significant increases were noted in the noncancer group . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
75,
83
]
} | {
"id": "C0037871",
"name": "ratio",
"pos": [
144,
149
]
} |
rbc putrescine ( p less than .001 ) , spermidine ( p less than .01 ) , and spermine ( p less than .005 ) levels , and the putrescine-spermidine ratio ( p less than .001 ) increased in the cancer group while no significant increases were noted in the noncancer group . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
4,
14
]
} | {
"id": "C0037871",
"name": "ratio",
"pos": [
144,
149
]
} |
when cancer patients of similar nutritional status were matched with the noncancer group , increases in rbc putrescine level and putrescine-spermidine ratio were noted in the selected cancer patients . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
108,
118
]
} | {
"id": "C0037871",
"name": "ratio",
"pos": [
151,
156
]
} |
cell kinetics studies of patients with various gliomas published in the past decade have shown that the average labeling index ( li ) obtained from a pulse of 3h-thymidine is very high in medulloblastomas ( 12.0 % +/- 1.3 % , standard error of the mean ) and glioblastoma multiforme ( 9.3 % +/- 1.0 % ) , low in well differentiated gliomas ( less than 1 % ) , and intermediate in anaplastic astrocytomas ( 4.0 % +/- 0.8 % ) . | NA | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
188,
204
]
} | {
"id": "C0017638",
"name": "gliomas",
"pos": [
332,
339
]
} |
patch test responses to sb and benzoic acid ( ba ) , without occlusion , were similar to those of three previously unexposed controls in keeping with the nonimmunologic nature of the reaction . | NA | {
"id": "C0142805",
"name": "sb",
"pos": [
24,
26
]
} | {
"id": "C0053225",
"name": "benzoic acid",
"pos": [
31,
43
]
} |
isolated articular cartilage chondrocytes from 1- to 3-week-old male holstein calf knee joints were formed into pellets containing 4 x 10 ( 6 ) isolated cells and were grown in tissue culture medium ( minimum essential medium/nctc 135 ) containing either 1 or 10 % newborn calf serum ( nbcs ) in plastic petri dishes in 5 % co2 and air at 37 degrees c in saturation humidity . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
29,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
153,
158
]
} |
the purpose of this study was to characterize the respiratory and calcium transport properties of isolated mammalian growth plate chondrocytes and mitochondria obtained from these cells and to quantitate the mitochondrial weight and volume fraction in each zone of the growth plate . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
130,
142
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
180,
185
]
} |
the transfer of trh from mucosal to serosal solutions was inhibited by the replacement of medium na ions by k ions and by the existence of oligopeptides . | NA | {
"id": "C0040162",
"name": "trh",
"pos": [
16,
19
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
139,
152
]
} |
on the assumption that the saturable transport process involves a common carrier for these antibiotics , the predicted extents of mutual inhibition using the in situ kinetic parameters were in good agreement with the experimental values for cephalexin and cephradine . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
241,
251
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
256,
266
]
} |
the effects of cephalexin and cefadroxil on the absorption of cyclacillin were also consistent with a common transport mechanism . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
15,
25
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
30,
40
]
} |
therefore , the booster effect of this carrageenan preparation on antitumor activity of mitomycin c is assumed to be associated with the inflammatory activity of this sulfated polysaccharide . | NA | {
"id": "C0007289",
"name": "carrageenan",
"pos": [
39,
50
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
176,
190
]
} |
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