text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
this is a case report of angiolymphoid hyperplasia with eosinophilia occurring in a 12-year-old caucasian boy with elevated levels of serum ige . | NA | {
"id": "C0002989",
"name": "angiolymphoid hyperplasia",
"pos": [
25,
50
]
} | {
"id": "C0014457",
"name": "eosinophilia",
"pos": [
56,
68
]
} |
the irf chick model will be useful to provide information on renal aspects of the toxicity , distribution , metabolism , and elimination of nephrotoxic agents . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
108,
118
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
125,
136
]
} |
increasing tp from dcp resulted in a significant linear increase in feed consumption ( p less than .05 ) , feed conversion ratio , and haugh units ( p less than .005 ) . | NA | {
"id": "C0031705",
"name": "tp",
"pos": [
11,
13
]
} | {
"id": "C0795598",
"name": "dcp",
"pos": [
19,
22
]
} |
increasing tp from dcp also resulted in a significant linear decrease in shell quality ( p less than .05 ) and significant linear and quadratic decreases in egg weight ( p less than .005 ) during the first year . | NA | {
"id": "C0031705",
"name": "tp",
"pos": [
11,
13
]
} | {
"id": "C0795598",
"name": "dcp",
"pos": [
19,
22
]
} |
during the second year , increasing tp from dcp resulted in a significant linear decrease in egg production rate ( p less than .005 ) and feed efficiency but significant linear ( p less than .01 ) and quadratic ( p less than .05 ) increases in feed consumption , and significant linear and quadratic increases ( p less than .005 ) in haugh units . | NA | {
"id": "C0031705",
"name": "tp",
"pos": [
36,
38
]
} | {
"id": "C0795598",
"name": "dcp",
"pos": [
44,
47
]
} |
when egg production rate and most other response criteria were considered , .5 % tp with dcp as the supplemental source gave the best results in both production years . | NA | {
"id": "C0031705",
"name": "tp",
"pos": [
81,
83
]
} | {
"id": "C0795598",
"name": "dcp",
"pos": [
89,
92
]
} |
the results from three 2-week observation periods indicated no significant differences in percent hen-day production , grams of feed per gram of egg mass , or overall body weight change but feed intake per day , egg weight , and shell thickness were significantly reduced by mean temperatures of 26.7 and 29.4 c in cycling chambers . | NA | {
"id": "C0005911",
"name": "body weight change",
"pos": [
167,
185
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
216,
222
]
} |
although 1,25 ( oh ) 2d3 is not incorporated into the egg adequately , its precursor , 25-hydroxyvitamin d3 ( 25-oh-d3 ) , is . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
87,
107
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
110,
118
]
} |
in view of the part played by renal prostaglandins in the mechanisms responsible for pain in renal colic , it was worth trying to find out whether nonsteroidal anti-inflammatory agents , which inhibit prostaglandin synthesis , have an analgesic effect of their own . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
85,
89
]
} | {
"id": "C0152169",
"name": "renal colic",
"pos": [
93,
104
]
} |
some authors advocate the use of the latest tetracyclines and doxycycline could also be administered . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
44,
57
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
62,
73
]
} |
we have investigated factors that recognize the splice junctions for mrna by means of a rapid and sensitive filter binding assay using chemically synthesized single-stranded ( ss ) dna ( 16-21 nucleotides ) that includes a splice junction sequence or using rna transcribed from the dna . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
158,
173
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
282,
285
]
} |
block of ca2+ currents by the dihydropyridine drug nitrendipine was studied in single canine ventricular cells by using the whole-cell variant of the patch clamp technique . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
30,
45
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
51,
63
]
} |
the addition of phorbol 12-myristate 13-acetate ( pma ) , a potent tumor promoter , to serum-starved quiescent chicken embryo fibroblasts ( cef ) or c127 murine cells resulted in increased phosphorylation of 40s ribosomal protein s6 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
126,
137
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
161,
166
]
} |
two-dimensional gel electrophoretic analysis of protein synthesis in mutant tissue at a restrictive temperature shows that the synthesis of three proteins is elevated and the synthesis of three other proteins is reduced , when compared to wild type . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
56,
65
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
200,
208
]
} |
although measurements in individual cases were quite reproducible and the amount of antigen detected by monoclonal antibodies reacting with different epitopes was quite similar , there was considerable variation between patients . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
84,
91
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
150,
158
]
} |
( ii ) double staining of the same sections with sheep anti-gludcase and rabbit anti-peptide antisera , the bound antibodies being localized by rhodamine-conjugated donkey anti-sheep and fluorescein-conjugated swine anti-rabbit secondary antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
114,
124
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
238,
246
]
} |
partial characterization of the neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
71,
91
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
96,
117
]
} |
the second peak was eluted in the same region as synthetic cck octapeptide , and sequence analysis showed that the chemical structure of this biologically active region of canine cck is identical to that found in sheep and pig brains . | NA | {
"id": "C0037167",
"name": "cck octapeptide",
"pos": [
59,
74
]
} | {
"id": "C0008328",
"name": "cck",
"pos": [
179,
182
]
} |
viral rna levels were different for each cell clone examined [ between 0.05 % and 0.5 % of the poly ( a ) + rna ] , and transcription was initiated and terminated in the long terminal repeats as in permissive differentiated cells . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
0,
9
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
108,
111
]
} |
enzymes processing somatostatin precursors : an arg-lys esteropeptidase from the rat brain cortex converting somatostatin-28 into somatostatin-14 . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
109,
124
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
130,
145
]
} |
the post-translational proteolytic conversion of somatostatin-14 precursors was studied to characterize the enzyme system responsible for the production of the tetradecapeptide either from its 15-kda precursor protein or from its cooh-terminal fragment , somatostatin-28 . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
49,
64
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
255,
270
]
} |
it is concluded that this arg-lys esteropeptidase from the brain cortex may be involved in the in vivo processing of the somatostatin-28 fragment of prosomatostatin into somatostatin-14 , the former species being an obligatory intermediate in a two-step proteolytic mechanism leading to somatostatin-14 . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
121,
136
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
287,
302
]
} |
quantitation of unlabeled glycosaminoglycans by hplc analysis of disaccharides generated by digestion with chondroitin abc and ac lyases ( ec 4.2.2.4 and 4.2.2.5 ) demonstrated that net accumulation of hyaluronate increased 2-fold and that hyaluronate represented 80 % of total chondroitinase-sensitive glycosaminoglycan produced by the cocultures . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
107,
118
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
303,
320
]
} |
cell contact between lx-1 and fibroblasts thus appears to be necessary for the stimulation of hyaluronate synthesis . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} |
analysis of pulmonary collagen production by high performance liquid chromatographic separation of radiolabeled hydroxyproline and proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
112,
126
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
131,
138
]
} |
in acute experiments , rosaprostol lowered pentagastrin-stimulated acid secretion by 27-36 % , whereas after chronic administration there were no changes in acid secretion or gastrin release ( fasting and oxo-stimulated ) but n-acetylneuraminic acid ( nana ) -glycoproteins increased significantly . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
43,
55
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
175,
182
]
} |
the amount of other mono-hete 's ( migrating in the vicinity of 12-hete ) was greater , but this was obviously mainly due to the small amount of contaminating platelets . | NA | {
"id": "C0020349",
"name": "hete 's",
"pos": [
25,
32
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
64,
71
]
} |
in order to investigate the physiological roles of prostaglandins during pregnancy , delivery and the postpartum period , the plasma concentration of 6-keto prostaglandin f1 alpha ( 6-keto pgf1 alpha ) , a stable metabolite of prostacyclin , thromboxane b2 ( txb2 ) , a stable metabolite of thromboxane a2 , and 13,14-dihydro-15-keto prostaglandin f ( pgfm ) were measured by specific radioimmunoassay . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
51,
65
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
334,
349
]
} |
nicardipine , a new 1,4-dihydropyridine derivative with ca++-antagonist activity , was tested on rabbit aortic strips contracted with k+ and na , and on an isolated guinea pig heart perfused at constant flow . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
0,
11
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
24,
39
]
} |
relative potencies of beta-adrenergic ligands were : propranolol greater than alprenolol greater than timolol greater than pindolol greater than isoproterenol greater than epinephrine greater than soterenol greater than metoprolol greater than terbutaline greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
172,
183
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
269,
283
]
} |
incorporation of 14c-proline into the thoracic aorta , abdominal aorta and mesenteric artery was higher and the hydroxyproline content of the abdominal aorta and mesenteric artery was higher than in the control rats . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
21,
28
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
112,
126
]
} |
effects of the aminoglycosides , gentamicin , netilmicin and tobramycin ( 30 mg/kg/day x 7 , i.p . ) , on glomerular ultrastructure were determined in male wistar rats . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
15,
30
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
33,
43
]
} |
both tem and sem , indicate that the nephrotoxic aminoglycosides gentamicin and tobramycin alter the ultrastructure of the fenestrated endothelia of the glomerular capillaries . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
49,
64
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
65,
75
]
} |
complement damages membranes via the terminal reaction sequence that leads to the formation of membrane-bound , macromolecular c5b-9 ( m ) protein complexes . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
0,
10
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
127,
132
]
} |
including a 24 amino acid signal peptide and four arginines in the beta-alpha transition region , which are probably not contained in the mature protein , the unglycosylated single chain precursor protein preproc3 would have a molecular mass of 186 484 da and consist of 1663 amino acid residues . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
145,
152
]
} | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
187,
204
]
} |
based on previous reports , we selected doses of progesterone ( p ) , desoxycorticosterone acetate ( doca ) , 5-alpha-dihydroprogesterone ( dhp ) and 20-alpha-hydroxyprogesterone ( 20-ohp ) that were expected to have initial facilitative and/or subsequent inhibitory actions on sexual receptivity . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
49,
61
]
} | {
"id": "C0012311",
"name": "20-alpha-hydroxyprogesterone",
"pos": [
150,
178
]
} |
removal of phenol and further purification of the plasmid preparation is achieved by consecutive precipitations with isopropanol and spermine , followed by extraction with ethanol , producing samples suitable for restriction endonuclease digestion , ligation , and transformation of s. lividans protoplasts or competent e. coli cells in about 2 h . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
117,
128
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
172,
179
]
} |
blood was drawn from 14 normal volunteers twice before , immediately after a 1-minute immersion of the nondominant hand in ice water ( cold pressor test ) , and twice during recovery . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
44,
47
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
127,
132
]
} |
in a retrospective study , children referred to the maudsley hospital with conduct or emotional disorders who also suffered from hallucinations were found to be older than other children seen with similar diagnoses , more of them had below-average iqs and they were more frequently admitted as in-patients . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
27,
35
]
} | {
"id": "C1455726",
"name": "older",
"pos": [
161,
166
]
} |
when gaba-potentiating compounds were administered ip to rats with prior experience of mouse-killing behaviour , a reduction of killing was observed with gamma-vinyl gaba ( 200 and 400 mg/kg ) and nipecotic acid amide ( 400 mg/kg ) , while no significant effect was noted following injection of dipropylacetate or thip . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
5,
9
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
154,
170
]
} |
when gaba-potentiating compounds were administered to food-deprived rats exposed for the first time to a mouse ( initial elicitation ) , administration of gamma-vinyl gaba , dipropylacetate , nipecotic acid amide or thip increased the incidence of mouse-killing behaviour . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
5,
9
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
155,
171
]
} |
the percentage increase during clonidine withdrawal of the norepinephrine metabolite normetanephrine was greater than were those of vanillylmandelic acid , 3-methoxy-4-hydroxyphenylglycol ( mhpg ) , or the epinephrine metabolite metanephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
59,
73
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
85,
100
]
} |
the percentage increase during clonidine withdrawal of the norepinephrine metabolite normetanephrine was greater than were those of vanillylmandelic acid , 3-methoxy-4-hydroxyphenylglycol ( mhpg ) , or the epinephrine metabolite metanephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
59,
73
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
206,
217
]
} |
the percentage increase during clonidine withdrawal of the norepinephrine metabolite normetanephrine was greater than were those of vanillylmandelic acid , 3-methoxy-4-hydroxyphenylglycol ( mhpg ) , or the epinephrine metabolite metanephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
229,
241
]
} |
these results suggest that heat , x irradiation , and combined treatment act in a different manner on the chromatin-associated enzyme or at different sites on the enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
127,
133
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
163,
177
]
} |
cell inactivation and induced mutation frequencies at the hypoxanthine-guanine phosphoribosyl transferase ( hgprt ) locus have been measured in cultured human fibroblasts ( gm10 ) exposed to alpha particles from 238pu ( let at the cell surface was 100 kev/microns ) and 250 kvp x rays . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
159,
170
]
} |
any appreciable cross-reactivity was observed neither with known metabolites of haloperidol nor with haloperidol decanoate ( kd-136 ) . | NA | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
80,
91
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
101,
122
]
} |
about a half of the talc powders revealed the presence of asbestos : in five samples chrysotile ( a serpentine asbestos ) was present , in the other ones tremolite and anthophyllite ( an amphibole asbestos ) . | NA | {
"id": "C0003947",
"name": "asbestos",
"pos": [
58,
66
]
} | {
"id": "C0142056",
"name": "serpentine asbestos",
"pos": [
100,
119
]
} |
about a half of the talc powders revealed the presence of asbestos : in five samples chrysotile ( a serpentine asbestos ) was present , in the other ones tremolite and anthophyllite ( an amphibole asbestos ) . | NA | {
"id": "C0003947",
"name": "asbestos",
"pos": [
58,
66
]
} | {
"id": "C0206121",
"name": "amphibole asbestos",
"pos": [
187,
205
]
} |
five subjects were injected with 5,000 iu of commercial heparin and low-molecular-weight heparin at an interval of 20 days after each injection . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
56,
63
]
} | {
"id": "C0019139",
"name": "low-molecular-weight heparin",
"pos": [
68,
96
]
} |
both heparins produced the same platelet factor 4 release immediately after administration ( commercial heparin 114.6 +/- 21.6 ng/ml , low-molecular-weight heparin 113.1 +/- 22.1 ng/ml ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
5,
12
]
} | {
"id": "C0019139",
"name": "low-molecular-weight",
"pos": [
135,
155
]
} |
15 asthmatic patients ( mean age 21.1 +/- 10.7 ) , eia positive ( free running test ) , were selected for a double-blind cross-over study of a sustained-release theophylline preparation against placebo . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
3,
12
]
} | {
"id": "C0004099",
"name": "eia",
"pos": [
51,
54
]
} |
cell-mediated immunity to retinal antigens as determined by in vitro assays has been detected in a variety of retinal degenerative and retinal destructive conditions . | NA | {
"id": "C0035304",
"name": "retinal degenerative",
"pos": [
110,
130
]
} | {
"id": "C0035309",
"name": "retinal",
"pos": [
135,
142
]
} |
substance p ( sp ) is a polypeptide formed by 11 amino acids of the tachykinin family . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
0,
11
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
68,
78
]
} |
however , these studies can not be completely comparable owing to a marked methodological dishomogeneity in definition of epilepsy , classification of seizures , and ascertainment , collection , and selection of the cases . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
122,
130
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
151,
159
]
} |
a fluorometric assay for the cytochrome p-450-dependent enzyme system , aryl hydrocarbon hydroxylase ( ahh ) , was performed in mitogen-activated human lymphocytes from over 300 different humans and from 64 baboons . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
29,
45
]
} | {
"id": "C0003927",
"name": "aryl",
"pos": [
72,
76
]
} |
in 34 cases the tumor formations where represented by hydatic cysts , abscesses and hemangiomata ( 3 cases ) . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
16,
21
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
62,
67
]
} |
this study showed a decrease in the cellular density ( number of chondrocytes per mm2 ) going from the superficial zone towards the calcified zone of the cartilage in all layers , as a function of the age of the subjects . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
36,
44
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
65,
77
]
} |
the decrease in cellular density is in the order of about 50 % of the total chondrocyte number when subjects younger than 40 are compared with those older than 80 . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
16,
24
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
76,
87
]
} |
the metabolic activity of the chondrocytes may also decrease with age , as suggested by the increasing proportion of alcianophobic cells , cells which are weakly or not at all labeled by radioactive sulfates which indicate the sites of biosynthesis of proteoglycans . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
30,
42
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
} |
the n-terminal tridecapeptide - lacking the bioactive tetrapeptide of gastrin-17 - is a potent inhibitor of gastric acid secretion , presumably by way of competitive antagonism to gastrin . | NA | {
"id": "C0039659",
"name": "tetrapeptide",
"pos": [
54,
66
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
180,
187
]
} |
assuming a possible oropharyngeal secretory immunoincompetence as an etiological component of im , the secretory iga concentrations in oral secretions during the acute phase of im was investigated . | NA | {
"id": "C0036538",
"name": "secretory",
"pos": [
34,
43
]
} | {
"id": "C0020838",
"name": "secretory",
"pos": [
103,
112
]
} |
the mortality observed in e+ infected mice after benzylpenicillin i.v . was 75 % , after benzylpenicillin procaine s.c . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
49,
65
]
} | {
"id": "C0030830",
"name": "benzylpenicillin",
"pos": [
89,
105
]
} |
analysis of sulfamethoxazole in serum from patients treated with trimethoprim-sulfamethoxazole was performed with the agar diffusion assay which is supposed to measure only unconjugated sulfonamide and with the spectrophotometric method which enables one to measure both unconjugated and conjugated sulfonamide . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
12,
28
]
} | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
65,
94
]
} |
at follow-up also more patients in the turp group had urinary incontinence although only one patient in this group with benign histology had daily urinary urge incontinence . | NA | {
"id": "C0042024",
"name": "urinary incontinence",
"pos": [
54,
74
]
} | {
"id": "C0150045",
"name": "urinary urge incontinence",
"pos": [
147,
172
]
} |
confirming earlier results increased levels of gags ( predominately of chondroitin and dermatan sulphate ) were found in the aortae of uraemic rats . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
71,
82
]
} | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
87,
104
]
} |
there was a statistically significant correlation between the aortic content of calcium and the serum calcium x phosphate product . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
80,
87
]
} | {
"id": "C0006711",
"name": "calcium",
"pos": [
102,
109
]
} |
the combination of illness ( trauma , burn , surgery , metabolic coma etc . ) and iatrogenic factors ( foreign bodies , ventilation , drugs etc . ) make them more susceptible to severe infections . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
29,
35
]
} | {
"id": "C0006434",
"name": "burn",
"pos": [
38,
42
]
} |
the combination of illness ( trauma , burn , surgery , metabolic coma etc . ) and iatrogenic factors ( foreign bodies , ventilation , drugs etc . ) make them more susceptible to severe infections . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
29,
35
]
} | {
"id": "C0016542",
"name": "foreign bodies",
"pos": [
103,
117
]
} |
sedation and ventilation may mask the primary symptoms of septicemia , and in these cases the condition is not diagnosed until signs of complications ( shock , disseminated intravascular coagulation , multiple organ failure ) appear . | NA | {
"id": "C0036974",
"name": "shock",
"pos": [
152,
157
]
} | {
"id": "C0026766",
"name": "multiple organ failure",
"pos": [
201,
223
]
} |
the mechanisms capable of overcoming the surrounding inhibition and thus leading to the spread of epileptic activity are not fully understood as yet : seizure-related changes in the extracellular ionic environment appear to support the spreading process . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
98,
107
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
151,
158
]
} |
by this method , analysis of seizures and differential diagnosis between hysterical and epileptic seizures has become much easier . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
29,
37
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
88,
97
]
} |
amongst the multiple genetic factors determining the common forms of hyperlipidemia , the apolipoprotein genes coding for the major peptides of the plasma lipoproteins ( chylomicrons , vldl , ldl and hdl ) may be of particular relevance since the latter form a system of inter-converting particles for the delivery of lipid ( triglyceride and cholesterol ) to peripheral tissues ( including the arterial wall ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
155,
167
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
170,
182
]
} |
the susceptibility of the chimpanzee to htlv-iii infection and the ability to simulate the human lymphadenopathy syndrome in this animal makes it a valuable model for further study of aids . | NA | {
"id": "C0019693",
"name": "htlv-iii infection",
"pos": [
40,
58
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
184,
188
]
} |
the tumor promoters 12-o-tetradecanoyl-phorbol-13-acetate and teleocidin markedly enhanced the transformation of c3h 10t1/2 mouse fibroblasts when these cells were transfected with the cloned human bladder cancer c-rash oncogene . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
130,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
153,
158
]
} |
these findings , together with parallel studies with nih 3t3 fibroblasts , also indicate that the competence of animal cells for dna transfection is a function of the recipient cell line , the transfected marker , and the growth conditions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
61,
72
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
218,
221
]
} |
antiserum to luteinizing hormone ( lh ) ( recognizing native lh ) , but not antiserum to lh-beta ( recognizing both native lh and its beta subunit ) , inhibited this induction . | NA | {
"id": "C0065261",
"name": "lh-beta",
"pos": [
89,
96
]
} | {
"id": "C0023607",
"name": "lh",
"pos": [
123,
125
]
} |
in normal children , fractures of the femoral neck are uncommon and accompany severe trauma and multiple injuries elsewhere in the skeleton [ 16 , 17 ] . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
85,
91
]
} | {
"id": "C0026771",
"name": "multiple injuries",
"pos": [
96,
113
]
} |
in children with gaucher disease , a rare hereditary disorder of lipid metabolism , midcervical or basicervical fractures can occur with minor or no trauma and without other injury to the skeleton . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
112,
121
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
149,
155
]
} |
while an increased incidence of scoliosis in symptomatic spondylolysis and spondylolisthesis has been established previously , a comparison of its occurrence in symptomatic and asymptomatic individuals has not been performed . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
57,
70
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
75,
92
]
} |
in the groups of : ( 1 ) asymptomatic unilateral spondylolysis , ( 2 ) asymptomatic bilateral spondylolysis , ( 3 ) symptomatic bilateral spondylolysis , and ( 4 ) asymptomatic spondylolisthesis the scoliosis incidence was similar , ranging from 13.3-23.8 % . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
49,
62
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
177,
194
]
} |
newborn annulus consists of an inner portion containing chondroblast-like cells , a middle portion showing cells with intermediate features between chondroblasts and fibroblasts , and an outer portion containing fibroblast-like cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
74,
79
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
212,
222
]
} |
the resulting fractures were similar to fractures observed clinically and showed a comminuted vertebral body with fractured vertebral end-plates , dislocated disc nucleus , bone fragments severely encroaching upon the spinal canal , and facet joint laxity . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
14,
23
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
83,
93
]
} |
the term 'gestational trophoblastic disease ' includes hydatidiform mole ( invasive and non-invasive ) , choriocarcinoma and a rare condition initially called trophoblastic pseudotumour and more recently placental site trophoblastic tumour . | NA | {
"id": "C0008497",
"name": "choriocarcinoma",
"pos": [
105,
120
]
} | {
"id": "C0206666",
"name": "placental site trophoblastic",
"pos": [
204,
232
]
} |
from 1 march 1982 to 30 november 1983 , 67 cycles in 47 patients were induced using clomiphene citrate and human chorionic gonadotrophin ( hcg ) ( 46 patients ) and human postmenopausal gonadotrophin/hcg ( 1 patient ) . | NA | {
"id": "C0018062",
"name": "human",
"pos": [
107,
112
]
} | {
"id": "C0018061",
"name": "gonadotrophin",
"pos": [
186,
199
]
} |
the primary structures of c3a , c4a , and c5a from man and from a number of animal species have been elucidated , and it is apparent that the three anaphylatoxins are genetically related . | NA | {
"id": "C0009510",
"name": "c3a",
"pos": [
26,
29
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
148,
162
]
} |
surgical treatment should be the treatment of choice in very acute cases also ( hematoma size , over 70 cm3 ) if the hematoma is diagnosed immediately after the onset of bleeding . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
80,
88
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
170,
178
]
} |
visual abnormalities varied in severity from moderately reduced visual acuity and diverse hemianopias and scotomas to blindness . | NA | {
"id": "C0018979",
"name": "hemianopias",
"pos": [
90,
101
]
} | {
"id": "C0456909",
"name": "blindness",
"pos": [
118,
127
]
} |
[ a case of dental focal infection with rheumatic fever and arthritis in the major joints ] . | NA | {
"id": "C0035436",
"name": "rheumatic fever",
"pos": [
40,
55
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
60,
69
]
} |
two closely related retinoids , all-trans and 13-cis retinoic acids , were assessed for their relative activities as teratogens in icr mice by monitoring the frequency with which either isomer produced discrete dysmorphogenesis of the embryonic limb and the secondary palate . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
20,
29
]
} | {
"id": "C0022265",
"name": "13-cis retinoic acids",
"pos": [
46,
67
]
} |
the patients ' plasmas neutralized both factor xi in plasma , purified factor xi , and purified factor xia . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
40,
49
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
96,
106
]
} |
there was no significant difference in id50 , whether the hef cultures were infected with cell-free or cell-associated vzv . | NA | {
"id": "C0016030",
"name": "hef",
"pos": [
58,
61
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
103,
107
]
} |
differentiation of neurons from cns cells and chondrocytes from lb cells was measured after 5 days of culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
36,
41
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
46,
58
]
} |
pre-treatment with the cyanide antagonist sodium thiosulfate also protected brain cytochrome a , a3 from cyanide-mediated redox state changes by approximately 4-fold both in normal blood circulated controls and during fc-43 circulation . | NA | {
"id": "C0037498",
"name": "cyanide",
"pos": [
23,
30
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
105,
112
]
} |
the preincubation step in nbt/acetone allows tetrazolium salt to bind firmly to tissue lipoprotein ( substantivity ) and diminishes the loss of reduced formazan from heavily reacting tissue sections . | NA | {
"id": "C0028147",
"name": "nbt",
"pos": [
26,
29
]
} | {
"id": "C0039704",
"name": "tetrazolium salt",
"pos": [
45,
61
]
} |
investigation of 122 women early in the second trimester of pregnancy who complained of constant dizziness during pregnancy , and used traditional `` '' black rings on their middle fingers '' '' as a prophylactic measure , revealed that 59 % were anaemic ( haemoglobin less than 10 g/100 ml ) . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
40,
56
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
114,
123
]
} |
polypeptides of fractions i and ii induce cationic and polypeptides of fraction iv -- cationic-anionic conductivity of blm . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
8,
9
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
95,
102
]
} |
the both proteins are capable of inducing the channel conductivity in blm which is selective to alkaline metals ions in case of alpha-su , alpha-sue modified blm possess some properties of na+ , k+-atpase : the cardial glucosides at large and small doses have a specific action , the action of the above glycosides and vanadate differs ; | NA | {
"id": "C0017765",
"name": "glucosides",
"pos": [
219,
229
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
304,
314
]
} |
glutamic acid , aspartic acid , alanine , glycine and serine were synthesized to a greater extent relative to the other amino acids , regardless of the precursor employed . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
32,
39
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
120,
131
]
} |
glutamic acid , aspartic acid , alanine , glycine and serine were synthesized to a greater extent relative to the other amino acids , regardless of the precursor employed . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
42,
49
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
120,
131
]
} |
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