text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it was found that doses of 0.10 and 0.13 g/kg body mass had a favourable effect on the appetite and the general state as well as on the indices studied , particularly on hb , blood sugar , amino acid index and urea of the blood serum , and ammonia gas , volatile fatty acids , and total count of infusoria in the rumen c... | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
240,
247
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
248,
251
]
} |
the addition of excessive amounts of methionine led to the sharp drop of the essential amino acids and rise of the free methionine in the blood serum of the test animals . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
77,
98
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
120,
130
]
} |
ultrastructural findings in autopsy material showed that the mesenchymal component consisted of undifferentiated mesenchymal cells , fibroblastic and fibrocytic cells with marked cellular and nuclear pleomorphism and that the epithelial component closely resembled the enamel organ . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
133,
145
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
179,
187
]
} |
the presence and distribution of different neural markers in 30 neuroblastic tumours ( neuroblastomas , ganglioneuroblastomas ) and 6 non-neuroblastic tumours were investigated by immunocytochemistry . | NA | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
87,
101
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastomas",
"pos": [
104,
125
]
} |
they also suggest that secretory iga ( siga ) is transported into alveolar spaces and the bronchiolar lumen through these cells by sc-mediated transport mechanism . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
23,
36
]
} | {
"id": "C0036538",
"name": "sc",
"pos": [
131,
133
]
} |
genomic length smv-rna ( mr of 3.3 x 10 ( 6 ] was found in specific association with edta-sensitive polyribosomes of infected leaves , indicating that it functions as a messenger rna in these cells . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
19,
22
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
169,
182
]
} |
these data suggest that genomic-length smv-rna is the only viral rna which is translated in these infected plants . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
43,
46
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
59,
68
]
} |
infection of serum-deprived human foreskin fibroblasts ( hff-cells ) by cytomegalovirus ( hcmv ) resulted in enhanced precursor incorporation into glycosphingolipids ( gsl ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
43,
54
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} |
immunoprecipitation of viral proteins from infected cells using hyperimmune mouse serum has demonstrated antigenic cross-reactivity among the nb proteins of the four virus strains studied . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
23,
37
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
145,
153
]
} |
the experiments described here indicate that virions in plasma , as well as particles from hepatitis b virus-infected human liver , also contain viral dna-rna hybrid molecules , and deoxynucleotides can be incorporated into the dna of these hybrids by dna polymerase activities in the virions . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
145,
154
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
252,
255
]
} |
fractionation of nucleic acid from cs2so4 density gradients by gel electrophoresis demonstrated that the majority of hybrid molecules migrated faster than molecules with the density of pure dna ( 1.42 g/cm3 ) . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
17,
29
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
190,
193
]
} |
one notable exception was the finding of dna-rna hybrid molecules migrating slower than open circular viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
93,
101
]
} |
characterization of viral dna-rna hybrids by heat denaturation cs2so4 density gradient fractionation , and recombinant m13-hbv single-stranded probe hybridization revealed that the hybrid molecules consisted of viral plus-strand rna hydrogen bonded to viral minus-strand dna sequences . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
30,
33
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
252,
257
]
} |
particles purified from the liver of hepatitis b virus-infected patients were previously shown by us to incorporate 32p-deoxynucleotides into viral dna and dna-rna hybrid molecules when incubated in a dna polymerase reaction mixture . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
142,
151
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
201,
204
]
} |
in this investigation , similar particles from duck and ground squirrel livers infected with viruses closely related to hbv were also shown to incorporate 32p-deoxynucleotides into viral-specific dna and dna-rna hybrid molecules when incubated in vitro in a dna polymerase reaction mixture . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
181,
186
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
258,
261
]
} |
levels of certain metabolites of peroxidation of lipids such as diene conjugates malonic dialdehyde , ascorbic acid , dehydroascorbic acid and diketogulonic acid were compared in 39 cases of gastric ulcer , 25 patients with gastric cancer and 14 healthy subjects . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
102,
115
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
118,
138
]
} |
the study was concerned with the influence of a long-term postnatal treatment with an antidiabetic biguanide-phenformin and a biologic stimulating agent-succinic acid upon the realization of transplacental carcinogenic effect of n-ethyl-n-nitrosourea ( enu ) in rats . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
99,
108
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
109,
119
]
} |
the latter became noninfectious for normal cef but retained its capacity for multiplication in cells treated with high concentrations of remantadine . | NA | {
"id": "C0016030",
"name": "cef",
"pos": [
43,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
95,
100
]
} |
specific inhibition of lassa virus replication in vero cells was found to be better achieved with immune gamma globulin in combination with complement than with gamma globulin alone . | NA | {
"id": "C0021027",
"name": "immune",
"pos": [
98,
104
]
} | {
"id": "C0017007",
"name": "gamma globulin",
"pos": [
161,
175
]
} |
reye 's syndrome ( encephalopathy with fatty infiltration of the viscera ) is an acute illness of childhood that produces hepatic dysfunction and metabolic encephalopathy . | NA | {
"id": "C0035400",
"name": "reye 's syndrome",
"pos": [
0,
16
]
} | {
"id": "C0006112",
"name": "metabolic",
"pos": [
146,
155
]
} |
the most important indications for the application of the catecholamines dopamine and dobutamine in the internal intensive medical care are acute disturbances of the peripheral vascular regulation and acute heart failure . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
58,
72
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
86,
96
]
} |
a retrospective examination has shown that the mortality of patients with a cardiogenic shock after an acute myocardial infarction could be lowered by a therapy of the current catecholamines dobutamine and dopamine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
176,
190
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
191,
201
]
} |
the secretory tissue of the eye , the ciliary processes , contains an enzyme receptor complex , composed of membrane proteins , the catalytic moiety of the enzyme adenylate cyclase , a guanyl nucleotide regulatory protein ( or n protein ) , and other features . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
70,
76
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
156,
162
]
} |
the secretory tissue of the eye , the ciliary processes , contains an enzyme receptor complex , composed of membrane proteins , the catalytic moiety of the enzyme adenylate cyclase , a guanyl nucleotide regulatory protein ( or n protein ) , and other features . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
108,
125
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
229,
236
]
} |
human fibroblasts and lymphocytes , and ehrlich ascites cells treated with polyarginine also form surface globular bodies similar in size . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
6,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
56,
61
]
} |
the concentration of heavy metals ( cobalt , nickel , copper , cadmium , mercury and lead ) , which are present at trace levels in the edible part of mussels ( mytilus galloprovincialis lamarck ) from hatcheries in the gulf of trieste , is normally or log-normally distributed , according to a statistical test sensitive... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
21,
33
]
} | {
"id": "C0009148",
"name": "cobalt",
"pos": [
36,
42
]
} |
the concentration of heavy metals ( cobalt , nickel , copper , cadmium , mercury and lead ) , which are present at trace levels in the edible part of mussels ( mytilus galloprovincialis lamarck ) from hatcheries in the gulf of trieste , is normally or log-normally distributed , according to a statistical test sensitive... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
21,
33
]
} | {
"id": "C0028013",
"name": "nickel",
"pos": [
45,
51
]
} |
the concentration of heavy metals ( cobalt , nickel , copper , cadmium , mercury and lead ) , which are present at trace levels in the edible part of mussels ( mytilus galloprovincialis lamarck ) from hatcheries in the gulf of trieste , is normally or log-normally distributed , according to a statistical test sensitive... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
21,
33
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
54,
60
]
} |
the concentration of heavy metals ( cobalt , nickel , copper , cadmium , mercury and lead ) , which are present at trace levels in the edible part of mussels ( mytilus galloprovincialis lamarck ) from hatcheries in the gulf of trieste , is normally or log-normally distributed , according to a statistical test sensitive... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
21,
33
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
63,
70
]
} |
the concentration of heavy metals ( cobalt , nickel , copper , cadmium , mercury and lead ) , which are present at trace levels in the edible part of mussels ( mytilus galloprovincialis lamarck ) from hatcheries in the gulf of trieste , is normally or log-normally distributed , according to a statistical test sensitive... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
21,
33
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
73,
80
]
} |
the concentration of heavy metals ( cobalt , nickel , copper , cadmium , mercury and lead ) , which are present at trace levels in the edible part of mussels ( mytilus galloprovincialis lamarck ) from hatcheries in the gulf of trieste , is normally or log-normally distributed , according to a statistical test sensitive... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
21,
33
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
85,
89
]
} |
it produces supplementary diagnosis of extraarticular findings like popliteal cysts ( baker 's cysts ) , aneurysms of popliteal artery , soft-tissue lesions , abscesses , hematomas , bursitis and varicosis , and of intra-articular disorders like effusion and synovial edema . | NA | {
"id": "C0006444",
"name": "bursitis",
"pos": [
183,
191
]
} | {
"id": "C0022408",
"name": "of",
"pos": [
212,
214
]
} |
similar telangiectasias have been observed in rarer patients with other connective tissue diseases ( sle , ra , dermatomyositis and undifferentiated connective tissue diseases ) . | NA | {
"id": "C0009782",
"name": "connective tissue diseases",
"pos": [
72,
98
]
} | {
"id": "C0011633",
"name": "dermatomyositis",
"pos": [
112,
127
]
} |
the work was concerned with the study of 57 gliomas , among which were 30 glioblastomas , 20 astrocytomas , and 7 oligodendrogliomas . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
74,
87
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
93,
105
]
} |
histologically , the ichthyosiform erythroderma of the newborn and the ichthyosis of the older child presented as a retention hyperkeratosis with several distinctive features such as calcification of the keratotic follicular plugs , atrophy of the hair follicles and focal hyperpigmentation of the basal keratinocytes . | NA | {
"id": "C0079583",
"name": "ichthyosiform erythroderma",
"pos": [
21,
47
]
} | {
"id": "C0020757",
"name": "ichthyosis",
"pos": [
71,
81
]
} |
cutaneous t-cell lymphomas ( ctcl ) are neoplasias of mature t-cells and comprise sezary syndrome , mycosis fungoides and some cases of lymphomatoid papulosis . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphomas",
"pos": [
0,
26
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
82,
97
]
} |
cutaneous t-cell lymphomas ( ctcl ) are neoplasias of mature t-cells and comprise sezary syndrome , mycosis fungoides and some cases of lymphomatoid papulosis . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphomas",
"pos": [
0,
26
]
} | {
"id": "C0206182",
"name": "lymphomatoid papulosis",
"pos": [
136,
158
]
} |
clinically this group of disorders differ from the more aggressive neoplasias of mature t-cells known as adult t-cell leukemia/lymphoma and t-cell lymphosarcoma leukemia which are associated with human t-cell leukemia virus ( htlv ) . | NA | {
"id": "C0023493",
"name": "adult t-cell leukemia/lymphoma",
"pos": [
105,
135
]
} | {
"id": "C0023492",
"name": "t-cell",
"pos": [
202,
208
]
} |
the effect of hydrocortisone on the release of luteinizing hormone ( lh ) and lh-releasing hormone ( lrh ) in response to clomiphene citrate ( clomiphene ) were examined in a sequential double chamber perifusion system by perifusing the mediobasal hypothalami ( mbh ) and/or pituitaries excised from normal female rats i... | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
122,
140
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
143,
153
]
} |
somatomedin levels in cerebrospinal fluid ( csf ) were determined in patients with acromegaly , pituitary deficiency , prolactinoma , and cushing 's disease by radioimmunoassay ( ria ) for insulin-like growth factor 1 ( igf-1 ) and for igf-2 as well as a radioreceptor assay ( rra ) with adult human brain plasma membran... | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
0,
11
]
} | {
"id": "C0021665",
"name": "insulin-like growth factor 1",
"pos": [
189,
217
]
} |
somatomedin levels in cerebrospinal fluid ( csf ) were determined in patients with acromegaly , pituitary deficiency , prolactinoma , and cushing 's disease by radioimmunoassay ( ria ) for insulin-like growth factor 1 ( igf-1 ) and for igf-2 as well as a radioreceptor assay ( rra ) with adult human brain plasma membran... | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
0,
11
]
} | {
"id": "C0021666",
"name": "igf-2",
"pos": [
327,
332
]
} |
no correlations were found between csf somatomedin levels determined by different techniques and immunoreactive igf-1 or gh in the peripheral circulation except for a positive correlation between csf ria-igf-2 and serum igf-1 in patients with acromegaly . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
39,
50
]
} | {
"id": "C0021666",
"name": "igf-2",
"pos": [
204,
209
]
} |
no correlations were found between csf somatomedin levels determined by different techniques and immunoreactive igf-1 or gh in the peripheral circulation except for a positive correlation between csf ria-igf-2 and serum igf-1 in patients with acromegaly . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
39,
50
]
} | {
"id": "C0021665",
"name": "igf-1",
"pos": [
220,
225
]
} |
these findings suggest that somatomedins in csf consist primarily of igf-2-like peptides which are derived from production within the central nervous system or pituitary gland rather than from transport across the blood-csf barrier . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
28,
40
]
} | {
"id": "C0021666",
"name": "igf-2",
"pos": [
69,
74
]
} |
on the other hand , plasma 17 alpha-hydroxyprogesterone , progesterone and 17 alpha , 20 alpha-dihydroxyprogesterone increased within 3-10 h before returning to basal values after 24 h . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
43,
55
]
} | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
95,
116
]
} |
in most instances , the diagnosis of septo-optic dysplasia can be established by physical examination and neuroradiologic findings , at which point a thorough evaluation of the hypothalamic-pituitary endocrine function is indicated because of the high incidence of hypopituitarism with this syndrome . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
190,
199
]
} | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
265,
280
]
} |
haemodynamic effects of fentanyl or alfentanil as adjuvants to etomidate for induction of anaesthesia in cardiac patients . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
24,
32
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
36,
46
]
} |
this investigation was designed to study the comparative haemodynamic effects of alfentanil , 5 mg vs. fentanyl 0.5 mg when administered in combination with etomidate for induction of anaesthesia in patients undergoing cardiac surgery . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
81,
91
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
103,
111
]
} |
in contrast to the fentanyl group , the systemic vascular resistance was transiently decreased in in the alfentanil group . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
19,
27
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
105,
115
]
} |
in conclusion , it appears that alfentanil is associated with a greater degree of cardiovascular depression than fentanyl when used in combination with etomidate as part of an induction sequence in cardiac surgery patients . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
32,
42
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
113,
121
]
} |
other labeled cells had characteristics of fibroblasts and were surrounded by an extracellular matrix rich in collagen fibrils . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
43,
54
]
} |
the paradox of cell type-specific morphological findings on the one hand and the generalized deficiency of n-acetylglucosamine-1-phosphotransferase representing the primordial enzyme deficiency in icd on the other , is resolved by postulating , outside the mannose-6-phosphate recognition marker targeting system , the e... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "cells",
"pos": [
455,
460
]
} |
staphylococcus aureus infection appears to be characterized by five major events : ( i ) cellular response , ( ii ) humoral response , ( iii ) mucociliary response , ( iv ) fibroblastic response , ( v ) bony response . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
89,
97
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
173,
185
]
} |
these components further interact with the complement system , as well as with immunologically nonspecific components like acute phase proteins ( e.g . c-reactive protein ) and with other pathophysiological phenomena occurring during infections , e.g . the fever response . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
123,
143
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
152,
170
]
} |
autopsy 10 years later revealed an asymptomatic cholangiocarcinoma of the left hepatic bile-duct , in which a gradual dedifferentiation could be seen from a central adenoma-like structure to an infiltrating adenocarcinoma peripherally . | NA | {
"id": "C0206698",
"name": "cholangiocarcinoma",
"pos": [
48,
66
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
207,
221
]
} |
it is therefore suggested that the relaxing effects of theophylline and enprofylline on srs-a-induced contractions , at the therapeutically relevant concentrations demonstrated in this study , might be of importance for the anti-asthmatic effects of xanthines . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
55,
67
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
250,
259
]
} |
the concentrations and alpha-methyl-p-tyrosine ( alpha-mpt ) induced disappearance of catecholamines , adrenaline , noradrenaline and dopamine , were measured in selected areas of the brainstem and hypothalamus of spontaneously hypertensive rats ( shr ) and deoxycorticosterone acetate ( doca ) -salt hypertensive rats . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
103,
113
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
116,
129
]
} |
on the other hand in doca-salt hypertensive rats , the concentrations of adrenaline and noradrenaline were the same as in control rats in the examined areas . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
73,
83
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
88,
101
]
} |
the immediate heart rate acceleration , blood pressure reaction , plasma adrenaline ( pa ) , and plasma noradrenaline ( pna ) responses to a 90 degrees and 2 sec tilt were evaluated in 13 male patients with type i diabetes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
73,
83
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
104,
117
]
} |
it was found that 76.4 % of malignant trophoblastic diseases originated from hydatidiform moles , 12.4 % from abortions , 9.5 % from normal deliveries , and 1.2 % from ectopic pregnancies . | NA | {
"id": "C2931618",
"name": "trophoblastic diseases",
"pos": [
38,
60
]
} | {
"id": "C0020217",
"name": "hydatidiform moles",
"pos": [
77,
95
]
} |
proteins with actual or potential antinutrient or toxicant activity found in foodstuffs include ( 1 ) enzyme inhibitors , especially those specific for serine proteinases and alpha-amylases , and ( 2 ) lectins ( hemagglutinins ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
0,
8
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
202,
209
]
} |
heat and alkali treatment of proteins catalyzes formation of crosslinked amino-acid side chains such as lysinoalanine , ornithino-alanine and lanthionine , and concurrent racemization of l-isomers of all amino acid residues to d-analogues . | NA | {
"id": "C0024347",
"name": "lysinoalanine",
"pos": [
104,
117
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
130,
137
]
} |
heat and alkali treatment of proteins catalyzes formation of crosslinked amino-acid side chains such as lysinoalanine , ornithino-alanine and lanthionine , and concurrent racemization of l-isomers of all amino acid residues to d-analogues . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
110,
117
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
204,
214
]
} |
they comprise a heterogeneous group of disorders sharing certain major clinical and morphologic features with the hereditary and acquired ataxias and with the extrapyramidal system disorders , such as parkinson 's disease and the hereditary and acquired choreas , yet distinct from both these general groups of neurodege... | NA | {
"id": "C0030567",
"name": "parkinson 's disease",
"pos": [
201,
221
]
} | {
"id": "C0524851",
"name": "neurodegenerative diseases",
"pos": [
311,
337
]
} |
thyroidectomized rats showed a decrease in ascorbic acid and dehydroascorbic acid , with almost no alterations in the diketogulonic acid in liver and kidney . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
43,
56
]
} | {
"id": "C0011177",
"name": "dehydroascorbic",
"pos": [
61,
76
]
} |
bethanidine suppressed the ability to initiate an arrhythmia in one patient with ventricular fibrillation during control stimulation . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
50,
60
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
81,
92
]
} |
to determine if severity of angina is related to the extent of coronary artery disease ( cad ) or prognosis , 341 patients were evaluated by a systematic physician-administered angina questionnaire at entry into a large-scale randomized study of medical vs surgical treatment of stable angina pectoris . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
28,
34
]
} | {
"id": "C0340288",
"name": "stable angina pectoris",
"pos": [
279,
301
]
} |
they may present as palpitations , syncope or cardiac arrest and have a strong association with heart disease . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
46,
60
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
96,
109
]
} |
propafenone prevented vt induction at electrophysiologic study in 6 patients , whereas another 12 patients were judged to have satisfactory electrophysiologic responses on the basis of slower vt rates and absence of hemodynamic compromise during vt . | NA | {
"id": "C0078888",
"name": "slower vt",
"pos": [
185,
194
]
} | {
"id": "C0042514",
"name": "vt",
"pos": [
246,
248
]
} |
the absorption of oxalate was investigated in a healthy subject after ingestion of oxalate-rich meals ( spinach and rhubarb ) with and without addition of 14c-labeled oxalic acid and calcium oxalate , and after oxalate-free meals with addition of nonlabeled sodium oxalate and calcium oxalate . | NA | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
167,
178
]
} | {
"id": "C0029988",
"name": "oxalate",
"pos": [
285,
292
]
} |
the absorption of oxalate was investigated in a healthy subject after ingestion of oxalate-rich meals ( spinach and rhubarb ) with and without addition of 14c-labeled oxalic acid and calcium oxalate , and after oxalate-free meals with addition of nonlabeled sodium oxalate and calcium oxalate . | NA | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
167,
178
]
} | {
"id": "C0006706",
"name": "calcium oxalate",
"pos": [
277,
292
]
} |
a comparison of the effect of diets containing beef protein and plant proteins on blood lipids of healthy young men . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
52,
59
]
} | {
"id": "C0032089",
"name": "plant proteins",
"pos": [
64,
78
]
} |
beef protein was substituted for 55 % of the plant proteins in the animal protein diet . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0032089",
"name": "plant proteins",
"pos": [
45,
59
]
} |
ninety-three percent of breast carcinomas , 85 % of mastopathic lesions not associated with a carcinoma , and 66 % of fibroadenomas showed positive reactions with commercial unabsorbed polyclonal anti-cea serum , which contained antibodies to nca , whereas incubation with monospecific anti-cea antiserum resulted in 42 ... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
229,
239
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
295,
304
]
} |
immediately after death , the plasma adrenalin level was higher than the noradrenalin level , but then adrenalin remained unchanged or tended to decrease while noradrenalin tended to increase gradually with time . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
37,
46
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
160,
172
]
} |
leukemic cells from ten patients with `` '' nonsecretory , '' '' b-type chronic lymphocytic leukemia ( cll ) were cultured alone or in the presence of epstein-barr virus ( ebv ) or a phorbol ester ( 12-0-tetradecanoylphorbol-13-acetate ; tpa ) for 7 days . | NA | {
"id": "C0031586",
"name": "a phorbol est",
"pos": [
181,
194
]
} | {
"id": "C0039654",
"name": "0-tetradecanoylphorb",
"pos": [
202,
222
]
} |
to test the hypothesis that a locus in or near the human major histocompatibility complex ( hla ) contributes to both involuntary fetal loss and neural tube defects ( ntd ) , we evaluated sharing of antigens of the hla-a , hla-b , or hla-dr loci of couples who had three or more first-trimester spontaneous abortions or ... | NA | {
"id": "C0019721",
"name": "antigens",
"pos": [
199,
207
]
} | {
"id": "C0019737",
"name": "hla-b",
"pos": [
223,
228
]
} |
to test the hypothesis that a locus in or near the human major histocompatibility complex ( hla ) contributes to both involuntary fetal loss and neural tube defects ( ntd ) , we evaluated sharing of antigens of the hla-a , hla-b , or hla-dr loci of couples who had three or more first-trimester spontaneous abortions or ... | NA | {
"id": "C0027794",
"name": "ntd",
"pos": [
167,
170
]
} | {
"id": "C0025312",
"name": "myelomeningocele",
"pos": [
350,
366
]
} |
to test the hypothesis that a locus in or near the human major histocompatibility complex ( hla ) contributes to both involuntary fetal loss and neural tube defects ( ntd ) , we evaluated sharing of antigens of the hla-a , hla-b , or hla-dr loci of couples who had three or more first-trimester spontaneous abortions or ... | NA | {
"id": "C0027794",
"name": "ntd",
"pos": [
167,
170
]
} | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
370,
381
]
} |
improved reagents could be designed that would simplify southern blot patterns by eliminating overlapping dna fragments and providing a single dna fragment for each locus . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
106,
109
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
161,
162
]
} |
four of the monoclonal antibodies and the rabbit antiserum crossreact with placental alkaline phosphatase , while none of the antibodies or the antiserum recognize liver or kidney alkaline phosphatase . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
12,
33
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
126,
136
]
} |
four of the monoclonal antibodies and the rabbit antiserum crossreact with placental alkaline phosphatase , while none of the antibodies or the antiserum recognize liver or kidney alkaline phosphatase . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
23,
33
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
144,
153
]
} |
aliquots of venous whole blood ( without anti-coagulant ) and serum from each subject were sealed in polypropylene plastic and glass containers and stored at 4 degrees c and 25 degrees c . | NA | {
"id": "C0032582",
"name": "polypropylene",
"pos": [
101,
114
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
115,
122
]
} |
during resuscitation , the correlation between the simultaneous epinephrine and norepinephrine levels was highly significant : r = 0.76 ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
64,
75
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
80,
94
]
} |
it is concluded that ( 1 ) chronic , severe stress produces only moderate elevations of plasma epinephrine levels ( up to 1.37 ng/ml ) , whereas acute stress produces marked increases of plasma epinephrine that may reach the extraordinarily high level of 35.9 ng/ml , ( 2 ) the potential toxicity from the adrenomedullar... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
95,
106
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
397,
411
]
} |
to examine correlations between paraneoplastic syndromes or constitutional symptoms and tumor behavior , the clinical and pathologic features were reviewed in 85 patients with small cell carcinoma of the lung who underwent complete autopsy at the johns hopkins hospital between 1962 and 1983 . | NA | {
"id": "C0030472",
"name": "paraneoplastic syndromes",
"pos": [
32,
56
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
88,
93
]
} |
the hemodynamic changes were accompanied by reductions in the plasma concentrations of norepinephrine but transient increases in plasma concentrations of epinephrine in patients in whom vasomotor syncope developed . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
87,
101
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
154,
165
]
} |
the absence of hypotension , clinical course , benign urinary sediments , and normal results of renal ultrasound examinations excluded acute tubular necrosis , pyelonephritis , interstitial nephritis , obstructive uropathy , and acute glomerulonephritis . | NA | {
"id": "C0034186",
"name": "pyelonephritis",
"pos": [
160,
174
]
} | {
"id": "C0027707",
"name": "interstitial",
"pos": [
177,
189
]
} |
the medullary and cortical segments of the thick ascending limb of henle absorb sodium chloride by active mechanisms as a result of a secondary active chloride transport mechanism that depends on the presence of sodium ( co-transport mechanism ) . | NA | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
80,
95
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
151,
159
]
} |
the diuretics that have a primary effect on the medullary segment ( furosemide , bumetanide , ethacrynic acid ) inhibit the concentrating mechanisms , whereas the diuretics that are effective primarily in the cortical segment ( thiazides plus the diuretics affecting the medullary segment ) inhibit the urinary diluting ... | NA | {
"id": "C0012798",
"name": "diuretics",
"pos": [
4,
13
]
} | {
"id": "C0012802",
"name": "thiazides",
"pos": [
228,
237
]
} |
these can be conveniently classified as : 1 ) conditions in which hba and s are present , 2 ) disorders where hbs is the predominant hemoglobin , and 3 ) the hbsf phenotype . | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
66,
69
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
133,
143
]
} |
since the pituitary secretion of gonadotropin was functionally restored by the administration of exogenous gonadotropin-releasing hormone , possibly there is a lack of secretion of endogenous gonadotropin-releasing hormone during the first trimester of pregnancy . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
10,
19
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
192,
204
]
} |
specific binding of 3h-wb-4101 was rapid , saturable , and exhibited the alpha-adrenergic agonist potency order of ( - ) -epinephrine inhibition constant [ ki ] = 0.6 mumol/l greater than ( - ) -norepinephrine ( ki = 1.5 mumol/l ) much greater than ( - ) -isoproterenol ( ki = 120 mumol/l ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
195,
209
]
} |
beta-endorphin was measured by radioimmunoassay in peripheral plasma of nonpregnant women ( 58 +/- 2.4 pg/ml , n = 17 , mean +/- se ) , during the first trimester ( 47 +/- 2.4 pg/ml , n = 11 ) , the second trimester ( 33 +/- 1.9 , n = 11 ) , and the third trimester ( 49 +/- 2.7 pg/ml , n = 10 ) of pregnancy , during ea... | NA | {
"id": "C0032979",
"name": "first",
"pos": [
147,
152
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
299,
308
]
} |
beta-endorphin was measured by radioimmunoassay in peripheral plasma of nonpregnant women ( 58 +/- 2.4 pg/ml , n = 17 , mean +/- se ) , during the first trimester ( 47 +/- 2.4 pg/ml , n = 11 ) , the second trimester ( 33 +/- 1.9 , n = 11 ) , and the third trimester ( 49 +/- 2.7 pg/ml , n = 10 ) of pregnancy , during ea... | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
199,
215
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
299,
308
]
} |
beta-endorphin was measured by radioimmunoassay in peripheral plasma of nonpregnant women ( 58 +/- 2.4 pg/ml , n = 17 , mean +/- se ) , during the first trimester ( 47 +/- 2.4 pg/ml , n = 11 ) , the second trimester ( 33 +/- 1.9 , n = 11 ) , and the third trimester ( 49 +/- 2.7 pg/ml , n = 10 ) of pregnancy , during ea... | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
250,
265
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
299,
308
]
} |
also , the mean plasma estradiol-17 beta and progesterone concentrations in patients with preterm labor who had term deliveries and in patients with preterm labor that progressed to preterm delivery were not different from each other or from patients delivering at term . | NA | {
"id": "C0022876",
"name": "preterm labor",
"pos": [
90,
103
]
} | {
"id": "C0151526",
"name": "preterm",
"pos": [
182,
189
]
} |
cultures of single drops of ophthalmic solution ( 25-microliter drops from each pipette bottle and 40-microliter drops from each squeeze bottle ) were done one minute , 15 minutes , one hour , two hours , and 24 hours after inoculation . | NA | {
"id": "C0015399",
"name": "drops",
"pos": [
19,
24
]
} | {
"id": "C0991568",
"name": "drops",
"pos": [
113,
118
]
} |
to estimate the usefulness of photographs of the retinal nerve fiber layer in demonstrating glaucomatous neural tissue changes , we examined such photographs of 51 patients with glaucoma , 52 patients with ocular hypertension , and 29 normal individuals . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
92,
100
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
206,
225
]
} |
we detected abnormal retinal nerve fiber layer changes in 48 of the patients with glaucoma , in 27 of those with ocular hypertension , and in five of the normal control subjects . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
82,
90
]
} | {
"id": "C0028840",
"name": "ocular",
"pos": [
113,
119
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.