text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
at the light-microscopic level the enu-induced tumors displayed the complex array of histotypic components described in a previous report ( hard gc , fox rr : histologic characterization of renal tumors ( nephroblastomas ) induced transplacentally in iiivo/j and wh/j rabbits by n-ethylnitrosourea . | NA | {
"id": "C0022665",
"name": "renal tumors",
"pos": [
190,
202
]
} | {
"id": "C0027708",
"name": "nephroblastomas",
"pos": [
205,
220
]
} |
the application of the principal axis method to quantitative attrition data provided a sensitive , objective evaluation of tooth wear . | NA | {
"id": "C0004277",
"name": "attrition",
"pos": [
61,
70
]
} | {
"id": "C2717979",
"name": "of tooth wear",
"pos": [
120,
133
]
} |
these in vitro findings suggest that da 3-sulfate may be effective in complementing the dopaminergic inhibition of aldo secretion at the adrenal level . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
37,
39
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
88,
100
]
} |
liver glycogen increased linearly after 20 min , and glycogen storage was equal in liver ( 38.4 % ) and muscle ( 36.5 % ) . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
0,
14
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
53,
61
]
} |
the high-km system was inhibited primarily by neutral amino acids with small or polar side chains ( alanine , serine , threonine , and glycine ) , resembling the asc system in its specificity . | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
46,
65
]
} | {
"id": "C0036720",
"name": "serine",
"pos": [
110,
116
]
} |
monoclonal antibodies can be generated with the hybridoma technique and offer the advantage of being a pure antibody derived from a single antibody-producing cell directed at a single antigenic determinant . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
139,
147
]
} |
together these results suggest that phosphate limitation reduces dicarboxylate anion availability to mitochondria and that this inhibition may contribute to the overall reduction in oxidative metabolism and jv observed under these conditions . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
36,
45
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
79,
84
]
} |
volumes were normalized against body weight , height , body surface area , leanness index , and lean body mass ( estimated from body weight and height ) . | NA | {
"id": "C0039870",
"name": "leanness",
"pos": [
75,
83
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
128,
139
]
} |
we now report that significant increases in rat lung adenosylmethionine decarboxylase activity and levels of the diamine putrescine and the polyamines , spermidine and spermine , are produced by a single dose of monocrotaline ( mct ) . | NA | {
"id": "C0011957",
"name": "diamine",
"pos": [
113,
120
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
140,
150
]
} |
cerebral glucose metabolism ( cmrglu ) is decreased during acute and prolonged hypercapnic acidosis and during prolonged metabolic ( hcl ) acidosis ; | NA | {
"id": "C0001127",
"name": "hypercapnic acidosis",
"pos": [
79,
99
]
} | {
"id": "C0001122",
"name": "acidosis",
"pos": [
139,
147
]
} |
the two proteins correspond in electrophoretic mobility to the regulatory subunits of camp-dependent protein kinases i and ii , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
74,
82
]
} |
competition curves demonstrated half-maximal inhibition of 125i-porcine insulin binding at an unlabeled insulin concentration of 4 ng/ml . | NA | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
64,
79
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
104,
111
]
} |
the effects of the dihydropyridine calcium antagonists nimodipine , nitrendipine , and nisoldipine were studied on k+-induced and angiotensin ii ( ang ii ) -induced aldosterone secretion from isolated calf adrenal glomerulosa cells . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
19,
54
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
55,
65
]
} |
the effects of the dihydropyridine calcium antagonists nimodipine , nitrendipine , and nisoldipine were studied on k+-induced and angiotensin ii ( ang ii ) -induced aldosterone secretion from isolated calf adrenal glomerulosa cells . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
19,
54
]
} | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
87,
98
]
} |
the stimulation of release was demonstrated for each of the three ca : dopamine , norepinephrine , and epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
82,
96
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
103,
114
]
} |
arterial pco2 probably also affects a mucosal chloride-bicarbonate exchange process that results in its overall effect on electroneutral sodium chloride absorption by the distal colon . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
46,
54
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
137,
152
]
} |
although sulfate influx was found to be stimulated by negative intravesicular potentials , evidence is presented that sodium/sulfate cotransport is nevertheless an electroneutral event presumably involving 2 na+ per so2-4 . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
9,
16
]
} | {
"id": "C0074769",
"name": "sodium/sulfate",
"pos": [
118,
132
]
} |
under zero trans sodium conditions sodium-dependent sulfate influx was stimulated by the presence of intravesicular unlabeled sulfate ( trans stimulation ) ; | NA | {
"id": "C0074769",
"name": "sodium",
"pos": [
17,
23
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
126,
133
]
} |
kinetic analyses of the na+-k+-adenosine triphosphatase ( atpase ) system were performed in brain and heart preparations from young mature ( 4 mo old ) and healthy aged ( 25 mo old ) rats . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
9,
11
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
58,
64
]
} |
the initial 40-min run resulted in liver glycogen depletion , large decreases in plasma glucose and insulin concentrations , and a marked lowering of muscle glycogen . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
35,
49
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
157,
165
]
} |
in untrained dogs , sampled by venipuncture , pentobarbital ( 30 mg/kg iv ) decreased the plasma concentration of epinephrine ( e ) from 146 +/- 9 to 38 +/- 8 ( se ) pg/ml ( n = 46 ) and norepinephrine ( ne ) from 276 +/- 13 to 91 +/- 10 pg/ml ( both p less than 0.0005 ) , suggesting that barbiturate anesthesia suppres... | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
46,
59
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
290,
301
]
} |
in untrained dogs , sampled by venipuncture , pentobarbital ( 30 mg/kg iv ) decreased the plasma concentration of epinephrine ( e ) from 146 +/- 9 to 38 +/- 8 ( se ) pg/ml ( n = 46 ) and norepinephrine ( ne ) from 276 +/- 13 to 91 +/- 10 pg/ml ( both p less than 0.0005 ) , suggesting that barbiturate anesthesia suppres... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
114,
125
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
187,
201
]
} |
insofar as blinking is a dopaminergic parameter , these findings suggest that the dopamine hypothesis of schizophrenia is most relevant in patients with normal ventricles . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
25,
37
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
82,
90
]
} |
a high index of suspicion of chlamydial infection should exist when severe endometritis is diagnosed in patients with clinical histories of post-abortal state , pelvic inflammatory disease , secondary infertility or menometrorrhagia , and chronic pelvic pain . | NA | {
"id": "C0014179",
"name": "endometritis",
"pos": [
75,
87
]
} | {
"id": "C0242172",
"name": "pelvic inflammatory disease",
"pos": [
161,
188
]
} |
however , the possibility of rye antigens with several epitopes , of which at least one is specific for rye , could not be excluded . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
33,
41
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
55,
63
]
} |
the lymphocyte subpopulations were classified using monoclonal antibodies specific for b lymphocytes ( b1 antibodies ) , t lymphocytes ( t11 and okt3 antibodies ) , helper/inducer t cells ( t4 antibodies ) and suppressor/cytotoxic t cells ( t8 antibodies ) . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
52,
73
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
244,
254
]
} |
isolation of patient-related antigens from allergen extracts by means of protein a-sepharose-patient igg1,2,4 bio-affinity chromatography . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
29,
37
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
43,
51
]
} |
the use of n-methyl-n- ( t-butyldimethylsilyl ) trifluoroacetamide to prepare the t-butyldimethylsilyl derivatives of a number of organic compounds ( selected amino acids , alpha-keto acids , ketone bodies , free fatty acids , urea , glycerol , lactate , and pyruvate ) is reported . | NA | {
"id": "C0029224",
"name": "organic compounds",
"pos": [
130,
147
]
} | {
"id": "C0041942",
"name": "urea",
"pos": [
227,
231
]
} |
the products of the reaction , ( - ) -tetrahydrofolate and nadp+ , were separated on a sephadex g-10 column equilibrated with 50 mm nh4hco3 containing beta-mercaptoethanol and ethanol . | NA | {
"id": "C0025402",
"name": "mercaptoethanol",
"pos": [
156,
171
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
176,
183
]
} |
red cell membrane proteins as well as na , k-atpase were covalently attached to the plastic . p-benzoquinone should be generally useful for coupling membrane proteins , even in detergent solutions , to microtiter plate wells . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
18,
26
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
149,
166
]
} |
the method is sensitive to concentrations as low as 0.01 nmol/ml , and is specific for sn-protoporphyrin even in the presence of other porphyrins such as protoporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
135,
145
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
154,
168
]
} |
a necessary condition of the assay is that antibody must not inhibit enzyme activity , which makes it especially suitable for monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
43,
51
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
126,
147
]
} |
the calcofluor fluorescence , when standardized with microcrystalline cellulose , provided a measure of cell wall cellulose . | NA | {
"id": "C0669247",
"name": "microcrystalline",
"pos": [
53,
69
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
114,
123
]
} |
it works equally well at all cell densities up to and beyond confluence , and has been used with a variety of cells in culture , including 3t3 cells , bovine macrophages , rat mammary epithelial cells , mouse mammary tumor cell lines , and human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
246,
257
]
} |
this poly ( a ) + rna fraction was compared with a poly ( a ) + rna fraction isolated by a new procedure which involves specific binding of poly ( a ) + rna to messenger affinity paper ( map ) and its release in hot ( 70 degrees c ) water . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
18,
21
]
} | {
"id": "C0035696",
"name": "rna",
"pos": [
153,
156
]
} |
since the isolation of poly ( a ) + rna by map is much less time consuming than that by oligo ( dt ) column chromatography and since the poly ( a ) + rna can be recovered from map in small volumes , which avoids further loss during precipitations , it can be advantageously used for preparative isolation of poly ( a ) +... | NA | {
"id": "C0035696",
"name": "rna",
"pos": [
36,
39
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
321,
324
]
} |
in tissue culture media , low concentrations of collagens and procollagens may be quantitatively precipitated and readily collected by low-speed centrifugation . | NA | {
"id": "C0009325",
"name": "collagens",
"pos": [
48,
57
]
} | {
"id": "C0033235",
"name": "procollagens",
"pos": [
62,
74
]
} |
polyethylene glycol precipitation can be used to obtain collagens and procollagens from tissue culture media at either analytical or preparative scale , and since the polyethylene glycols do not bind to collagens , the precipitates may be further analyzed directly by chromatographic or electrophoretic methods . | NA | {
"id": "C0033235",
"name": "procollagens",
"pos": [
70,
82
]
} | {
"id": "C0009325",
"name": "collagens",
"pos": [
203,
212
]
} |
the deuterium content of [ 2,3-2h2 ] succinic acid , [ 2-2h2 ] succinic acid ( derived from l- [ 4-2h2 ] glutamic acid by oxidation ) and of the corresponding succinates isolated after incubation with isocitrate lyase was determined by gas chromatography-mass spectroscopy of their dimethylester under nh4+ chemical ioni... | NA | {
"id": "C0075429",
"name": "succinic acid",
"pos": [
37,
50
]
} | {
"id": "C0038617",
"name": "succinates",
"pos": [
159,
169
]
} |
glucose does not interfere with the assay while 2-deoxy-d-ribose develops a fluorescence which is about 15 % of that produced by the same amount of 2dg and is additive when both deoxy sugars are present together . | NA | {
"id": "C0011501",
"name": "2dg",
"pos": [
148,
151
]
} | {
"id": "C0011471",
"name": "deoxy sugars",
"pos": [
178,
190
]
} |
with rat tissue samples which contained very low concentrations of neopterin as compared to biopterin , biopterin was simultaneously determined by our previously reported radioimmunoassay , and neopterin values were corrected for the cross-reactivity ( 0.1 % ) . | NA | {
"id": "C0005562",
"name": "biopterin",
"pos": [
92,
101
]
} | {
"id": "C0068527",
"name": "neopterin",
"pos": [
194,
203
]
} |
the neopterin concentrations obtained by this method agreed with the values obtained by the radioimmunoassays for neopterin and biopterin after their separation by high-performance liquid chromatography . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
4,
13
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
128,
137
]
} |
this very small amount of neopterin , as compared with biopterin , in rat tissues could not be determined by high-performance liquid chromatography-fluorometry alone due to the masking of the neopterin peak by a large biopterin peak . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
26,
35
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
218,
227
]
} |
the technique has been applied to the contractile proteins myosin , actin , and commercially obtained standards resolved by one-dimensional electrophoresis , and to proteins in nuclear extracts of hela cells on two-dimensional gels . | NA | {
"id": "C0009915",
"name": "contractile",
"pos": [
38,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
165,
173
]
} |
cell membrane fusion was not caused by procaine , lidocaine , sodium bisulfite ( the antioxidant present in the commercial solutions of chloroprocaine ) , or chloro-aminobenzoic acid and diethylamino-ethanol ( the two chloroprocaine metabolites ) . | NA | {
"id": "C0033218",
"name": "procaine",
"pos": [
39,
47
]
} | {
"id": "C0055443",
"name": "metabolites",
"pos": [
233,
244
]
} |
the pharmacokinetics of sufentanil , a new thienyl analogue of fentanyl , were studied in 10 surgical patients . | NA | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
24,
34
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
63,
71
]
} |
since endotoxin , lipopolysaccharides ( lps ) , have been implicated as a causative factor in the development of hepatic necrosis in rats exposed to hepatotoxic levels of several chemical agents , the role of lps in the halothane-hypoxia ( hh ) model of hepatic damage in male sprague-dawley rats was investigated . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
6,
15
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
209,
212
]
} |
investigations of the epidemiology of bovine cysticercosis and human taeniasis were carried out in the county of wittstock from 1979 till 1980 . | NA | {
"id": "C0010678",
"name": "cysticercosis",
"pos": [
45,
58
]
} | {
"id": "C0039254",
"name": "taeniasis",
"pos": [
69,
78
]
} |
amino acid compositions of the two components were similar , and there were no differences in the n-terminus ( glutamic acid followed by glutamine ) and the c-terminus ( valine ) . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
111,
124
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
137,
146
]
} |
this method allows for simultaneous separation and quantification of these drugs ( ethosuximide , primidone , phenobarbital , beclamide , prominal , diphenylhydantoin , glutethimide , carbamazepine ) in a relatively short analysis time , by means of a system of radial compression of the column . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
98,
107
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
110,
123
]
} |
when aflatoxin-contaminated grain is consumed by dairy cows , aflatoxin m1 is excreted in the milk . | NA | {
"id": "C0001734",
"name": "aflatoxin",
"pos": [
5,
14
]
} | {
"id": "C0085181",
"name": "aflatoxin m1",
"pos": [
62,
74
]
} |
the sensitivity of caprine synovial membrane cells to the antiviral effects of natural and recombinant dna-derived human interferons ( huifn ) was compared with that of human foreskin fibroblast ( fs7 ) , ovine choroid plexus , and bovine turbinate cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
184,
194
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
249,
254
]
} |
to determine whether a protein carrier would substitute for ribosomes , methylated bovine albumin ( mba ) was combined with lps and evaluated as a vaccine . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
23,
30
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
90,
97
]
} |
the agent was recovered from synovial membrane explants , synovial fluid , colostrum cells , and peripheral blood mononuclear cells of clinically arthritic goats . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
85,
90
]
} | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
97,
113
]
} |
to evaluate the effects of volcanic ash and free crystalline silica on cells derived from the air space of the human lung , we compared the effects of these minerals on human alveolar macrophages and a549 cells , which are derived from human type ii pneumocytes . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
61,
67
]
} | {
"id": "C0026162",
"name": "minerals",
"pos": [
157,
165
]
} |
peripheral blood mononuclear cells ( pbmc ) and mitomycin-treated autologous bronchoalveolar cells ( bac ) were cocultured at various am-to-pbmc ratios , and were stimulated or not by phytohemagglutinin and concanavalin a . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
140,
144
]
} |
the bac from normal subjects were able to modify the lymphoproliferative responses of autologous pbmc to cell mitogens . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
97,
101
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
105,
109
]
} |
these results suggest that most cells in the normal as well as in the fibrotic interstitium , including contractile interstitial cells , are probably of mesenchymal ( fibroblastic ) rather than of smooth muscle origin . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
32,
37
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
167,
179
]
} |
finally , the humoral regulation of platelets production is considered , mainly the two factors which appear to regulate thrombocytopoiesis , that is to say : colony stimulating factor and thrombopoietin . | NA | {
"id": "C0009392",
"name": "colony stimulating",
"pos": [
159,
177
]
} | {
"id": "C0040052",
"name": "thrombopoietin",
"pos": [
189,
203
]
} |
they have used first ( cefacetrile ) , second ( cefamandole ) and third ( cefotaxime an moxalactam ) generation cephalosporins , in order to their disponibility . | NA | {
"id": "C0007714",
"name": "cefacetrile",
"pos": [
23,
34
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
74,
84
]
} |
we used data from a randomized double-blind trial in which the only observed difference between the clinical effects of these aminoglycosides was the incidence of nephrotoxicity ( 26 % with gentamicin and 12 % with tobramycin ) . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
126,
141
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
190,
200
]
} |
an extensive sensitivity analysis -- varying frequency and cost of nephrotoxicity , dialysis requirements , aminoglycoside acquisition costs , and length of hospitalization -- showed gentamicin to be more cost effective than tobramycin , unless hospitalization is prolonged by an average of at least 15 days for patients... | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
108,
122
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
183,
193
]
} |
future vaccines will involve recombinant and synthetic antigens , with emphasis on control of many different infections with single polyvalent vaccines directed against individual epitopes rather than complex antigens . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
180,
188
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
209,
217
]
} |
amiodarone , 2-n-butyl-3- ( 4'diethylaminoethoxy-3',5-diiodobenzoyl ) benzofuran , also known as cordarone , is presently under clinical investigation in the united states . | NA | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
0,
10
]
} | {
"id": "C0005068",
"name": "benzofuran",
"pos": [
70,
80
]
} |
the blood level of local anesthetics is determined by the rate of uptake , tissue redistribution , metabolism and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
99,
109
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
114,
123
]
} |
it is possible that the treatment combining heat and hydrogen peroxide was the most effective in reducing the concentrations of all bacteria , because catalase and peroxidases as well as other enzymes were heat inactivated , although catalase seems the most likely cause of damage . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
164,
175
]
} | {
"id": "C0007367",
"name": "catalase",
"pos": [
234,
242
]
} |
first , esr experiments involving spin-labeled phosphatidylserine , phosphatidic acid , and phosphatidylcholine demonstrated that , in the fluid-isotropic phase of dimyristoylphosphatidylcholine ( dmpc ) -rhodopsin membranes , the relative order of rhodopsin-induced immobilization was phosphatidic acid greater than pho... | NA | {
"id": "C0012456",
"name": "dimyristoylphosphatidylcholine",
"pos": [
164,
194
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
317,
336
]
} |
anionic 2-nitropropane undergoes an oxygenase reaction with 2-nitropropane dioxygenase and glucose oxidase , and an oxidase reaction with d-amino acid oxidase . | NA | {
"id": "C0030065",
"name": "oxygenase",
"pos": [
36,
45
]
} | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
75,
86
]
} |
hydrogen exchange kinetics of deoxyhemoglobin s gel and deoxyhemoglobin a solution were compared at 4.8 mm tetramer concentration , 25 degrees c , and in sodium phosphate buffer at ph 7.0 with gamma/2 = 0.2 by means of microdialysis using tritium as a trace label . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
0,
8
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
239,
246
]
} |
at 12 h after androgen deprivation ( i.e. , when a significant portion of the nuclear androgen receptor was known to be depleted ) , the rate , but not the extent , of phosphorylation of nuclear proteins ( predominantly nonhistone proteins ) was markedly reduced . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
187,
203
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
231,
239
]
} |
relatively high concentrations of centrophenoxine were required to achieve 50 % inhibition of the microsomal enzymes cdp-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase ( ept ) , cdp-choline:1,2-diacylglycerol cholinephosphotransferase ( cpt ) , phosphatidyl-n-methylethanolamine n-methyltransferase ( pme... | NA | {
"id": "C0070781",
"name": "phosphatidyl-n-methylethanolamine",
"pos": [
261,
294
]
} | {
"id": "C0025831",
"name": "methyltransferase",
"pos": [
375,
392
]
} |
antibodies to cytochrome p-450 isozyme 3a , the ethanol-inducible isozyme in rabbit liver , were used to determine the role of this enzyme in the microsomal oxidation of alcohols and the p-hydroxylation of aniline . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
31,
38
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
132,
138
]
} |
nine distinct monoclonal antibodies raised against purified rat liver cytochrome p-450c react with six different epitopes on the antigen , and one of these epitopes is shared by cytochrome p-450d . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
129,
136
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
156,
164
]
} |
anabolic and catabolic pathways of 5-fu pharmacokinetics of 5-fu-blood level , absorption , drug interaction tegafur ( ft ) -blood level , absorption , activation to 5-fu by p-450 uft-high 5-fu level in tissues , especially in tumor tissues , by inhibiting the catabolism of 5-fu from ft with uracil hcfu-relatively high... | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
109,
116
]
} | {
"id": "C0016360",
"name": "fu",
"pos": [
486,
488
]
} |
in this paper , the characterization of masked forms of 5-fu and fdurd were described as follows : metabolism of 5-fu and uracil . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
58,
60
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
122,
128
]
} |
supplemented infants lost less weight postnatally and regained birthweight more quickly : their improved weight gain continued after supplementation was stopped . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
31,
37
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
63,
74
]
} |
after this absorption eight guinea-pig sera contained antibodies specific for immune complexes isolated from the sera of three patients . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
54,
64
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
78,
94
]
} |
results of the damus-stansel-kaye procedure for transposition of the great arteries and for double-outlet right ventricle with subpulmonary ventricular septal defect . | NA | {
"id": "C0040761",
"name": "transposition of the great",
"pos": [
48,
74
]
} | {
"id": "C0013069",
"name": "double-outlet right ventricle",
"pos": [
92,
121
]
} |
from 1975 through 1982 , the damus-stansel-kaye procedure was performed on 20 patients with complete transposition of the great arteries ( tga ) and on 4 with double-outlet right ventricle ( dorv ) and subpulmonary ventricular septal defect ( vsd ) . | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
101,
136
]
} | {
"id": "C0013069",
"name": "double-outlet right ventricle",
"pos": [
159,
188
]
} |
postoperative complications included bleeding from the left coronary artery-pulmonary artery anastomosis ( 1 patient ) , stenosis of the pulmonary artery-aorta anastomosis requiring reoperation ( 2 patients ) , transient st segment and t wave abnormalities consistent with ischemia ( 3 ) , and development of pathologica... | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
273,
281
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
362,
372
]
} |
incremental risk factors for hospital mortality after the fontan procedure in patients with tricuspid atresia as well as other cardiac anomalies include young age ( p = 0.0003 ) , diagnosis other than tricuspid atresia ( p = 0.03 ) , and complex associated procedures ( p = 0.02 ) . | NA | {
"id": "C0018798",
"name": "cardiac anomalies",
"pos": [
127,
144
]
} | {
"id": "C0243002",
"name": "tricuspid atresia",
"pos": [
201,
218
]
} |
it is concluded that the rs-t displacement , the distal conduction block and arrhythmias are manifestations , at different levels , of partial diastolic depolarization induced by acute myocardial ischemia . | NA | {
"id": "C0018794",
"name": "conduction block",
"pos": [
56,
72
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
77,
88
]
} |
evidence obtained indicates that certain structural characteristics are needed for promoting heparin absorption , since this effect is observed with some but not all non-ionic detergents ( cetyl and stearyl ethers but not lauryl ) and bile components ( deoxycholic , chenodeoxycholic and cholic acids , but not ursodeoxy... | NA | {
"id": "C0008404",
"name": "cholic acids",
"pos": [
288,
300
]
} | {
"id": "C0011182",
"name": "dehydrocholic acids",
"pos": [
330,
349
]
} |
in a double-blind , long-term follow-up study , 117 bipolar patients received lithium carbonate , imipramine hydrochloride , or both and 150 unipolar patients received lithium carbonate , imipramine , both lithium carbonate and imipramine , or placebo . | NA | {
"id": "C0589978",
"name": "imipramine hydrochloride",
"pos": [
98,
122
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
228,
238
]
} |
co-storage of adrenaline and noradrenaline with met-enkephalin-arg6-gly7-leu8 and met-enkephalin-arg6-phe7 in chromaffin cells of hamster adrenal medulla . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
14,
24
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
29,
42
]
} |
paraffin embedded serial sections ( 3-4 microns thick ) of adrenal glands perfusion-fixed with either bouin 's fluid or 4 % paraformaldehyde solution were immunostained using anti-adrenaline ( ap16-2 ) , -noradrenaline ( nap1-18 ) , -met-enkephalin-arg6-gly7-leu8 ( met-enk-arg-gly-leu : r-0171 , ne2-206 ) and -met-enke... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
180,
190
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
205,
218
]
} |
selective and specific immunostaining for adrenaline and noradrenaline was obtained in tissues fixed in 4 % paraformaldehyde solution . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
42,
52
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
57,
70
]
} |
secretory granules in chromaffin cells were responsible for both adrenaline- and noradrenaline-like and met-enk-arg-gly-leu- and met-enk-arg-phe-like immunoreactivities . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
65,
75
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
81,
94
]
} |
surgical treatment of spondylolisthesis by bone grafting and direct stabilization of spondylolysis by means of a hook screw . | NA | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
22,
39
]
} | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
85,
98
]
} |
erythrocyte glutamine oxaloacetic acid transaminase ( egot ) activity with and without in vitro enhancement with pyridoxal phosphate was used as a means of identifying subjects with and without pyridoxine metabolic abnormalities . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
113,
132
]
} | {
"id": "C0034272",
"name": "metabolic",
"pos": [
205,
214
]
} |
the following sequence was established for the growth angle ( tan alpha ) of the essential 14n-amino acids : leu , lys , arg , thr , phe , ile , val , his and of the 15n-amino acids : lys , arg , val , leu , ile , thr , phe and his . | NA | {
"id": "C0002525",
"name": "essential",
"pos": [
81,
90
]
} | {
"id": "C0040005",
"name": "thr",
"pos": [
214,
217
]
} |
on average the blood contained per hen 77.9 % lysine-15n ' , 16.4 % arginine-15n ' and 5.7 % histidine-15n ' of the basic amino acid-15n ' . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
46,
52
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
116,
132
]
} |
on average the blood contained per hen 77.9 % lysine-15n ' , 16.4 % arginine-15n ' and 5.7 % histidine-15n ' of the basic amino acid-15n ' . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
68,
76
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
116,
132
]
} |
for the gastro-intestinal tract 78.7 % lysine-15n ' , 19.0 % arginine-15n ' and 2.3 % histidine-15n ' of the 15n ' of the basic amino acids were ascertained . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
39,
45
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
122,
139
]
} |
for the gastro-intestinal tract 78.7 % lysine-15n ' , 19.0 % arginine-15n ' and 2.3 % histidine-15n ' of the 15n ' of the basic amino acids were ascertained . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
61,
69
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
122,
139
]
} |
competition of a styrene metabolite with dopamine for the vesicular storage capacity or a selective destruction of dopaminergic terminals are suggested as the possible mechanisms for styrene neurotoxicity . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
41,
49
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
115,
127
]
} |
these effects were very similar to those elicited by comparable doses of sodium nitrite , except that the half-recovery time for return to normal blood pressure was somewhat longer with nitrite . | NA | {
"id": "C0037532",
"name": "sodium nitrite",
"pos": [
73,
87
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
186,
193
]
} |
[ study on peripheral blood mononuclear cell subpopulations in children . part 1. peripheral blood mononuclear cell subpopulations in healthy neonates , infants , young children and school children ] . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
63,
71
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
163,
177
]
} |
the appendices from 121 corpses of persons died at the age 1 day -- 83 years have been studied . | NA | {
"id": "C0006629",
"name": "corpses",
"pos": [
24,
31
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
90,
94
]
} |
we describe a sensitive and precise method for the simultaneous high pressure liquid-chromatography determination of phenobarbital , diphenylhydantoin , primidone , and carbamazepine in serum . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
117,
130
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
153,
162
]
} |
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