text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the results , when compared with those by enzyme-immunoassay , gave correlation coefficients of 0.990 for phenobarbital , 0.993 for diphenylhydantoin , 0.992 for primidone and 0.994 for carbamazepine . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
106,
119
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
162,
171
]
} |
we reviewed 317 patients with multiple sclerosis ( ms ) and found that the incidence of clinically significant pain , excluding headache and paresthesia , was 28.8 % . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
111,
115
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
128,
136
]
} |
mild dopa induced dyskinesia can be ignored but when it is troublesome the dose of levodopa should be reduced . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
5,
9
]
} | {
"id": "C0023570",
"name": "levodopa",
"pos": [
83,
91
]
} |
2'-deoxyadenosine , inosine , guanine , 2'-deoxyguanosine and the pyrimidines cytosine , cytidine , 2'-deoxycytidine , 2'-deoxythymidine and uridine all given at 100 mumoles/mouse and orotic acid given at 25 mumoles/mouse had no significant effects on the plaque response ; | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
89,
97
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
103,
116
]
} |
a urodynamic evaluation should be performed on most female patients suffering from urinary incontinence and is essential for patients who are being considered for surgery for recurrent stress incontinence . | NA | {
"id": "C0042024",
"name": "urinary",
"pos": [
83,
90
]
} | {
"id": "C0042025",
"name": "stress incontinence",
"pos": [
185,
204
]
} |
this study has been conducted to measure tissue ( brain and heart ) ca contents ( dopamine , norepinephrine , epinephrine ) of eels acclimatized for 15 d at two temperatures , tw , ( 15 degrees c or 25 degrees c ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
93,
107
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} |
following chemical mutagenesis and multiple-step indirect selection , four clones of chinese hamster v79 cells were isolated which exhibited auxotrophy for thymidine , deoxycytidine , or deoxyuridine but not for cytidine or uridine . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
168,
181
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
212,
220
]
} |
all were resistant to uridine , 3-deazauridine , 5-fluorouridine , thymidine , and cytosine arabinoside at concentrations that were toxic to wild-type v79 cells . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
22,
29
]
} | {
"id": "C0000399",
"name": "3-deazauridine",
"pos": [
32,
46
]
} |
this paper reports on the effects of carbamylation on the physicochemical properties of one of the major lens structural proteins , alpha-crystallin . | NA | {
"id": "C0010422",
"name": "lens",
"pos": [
105,
109
]
} | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
132,
148
]
} |
the anti-lipolytic effect of the adenosine analogue n6-l-phenylisopropyladenosine was studied with rat adipocytes incubated with a high concentration of adenosine deaminase ( 0.5 unit/ml , approx . 2.5 micrograms/ml ) and concentrations of noradrenaline that were equieffective in different physiological states . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
33,
42
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
57,
81
]
} |
the concentrations of hexose 6-phosphate increased continuously during the 1 min tetanus , whereas fructose 1,6-bisphosphate was increased at 10s and then decreased progressively . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
22,
28
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
99,
107
]
} |
this material has been tested in a variety of insulin-like growth factor ( igf ) /somatomedin assay systems . | NA | {
"id": "C0021666",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0037657",
"name": "insulin-like growth",
"pos": [
46,
65
]
} |
since igf-i and igf-ii , although homologous , have unique amino acid sequences , the conversion of both igfs implies that at least two acidic ila forms exist . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
6,
11
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
105,
109
]
} |
since igf-i and igf-ii , although homologous , have unique amino acid sequences , the conversion of both igfs implies that at least two acidic ila forms exist . | NA | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
16,
22
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
105,
109
]
} |
nevertheless , because ila pi 4.8 retains the full spectrum of igf bioactivities in vitro , and significant quantities are present in normal human serum ( 21 % ) , it would suggest that proteolytic conversion of igf-i , somatomedin a and igf-ii to ila pi 4.8 in vivo may be a physiologically significant event . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
63,
66
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
238,
243
]
} |
nevertheless , because ila pi 4.8 retains the full spectrum of igf bioactivities in vitro , and significant quantities are present in normal human serum ( 21 % ) , it would suggest that proteolytic conversion of igf-i , somatomedin a and igf-ii to ila pi 4.8 in vivo may be a physiologically significant event . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
63,
66
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
238,
244
]
} |
specificity was exhibited when sugar and sugar derivatives were used as competitors in the radioimmunoassay : a 51-fold range of competitive ability was found , and sialic acids ( n-acetylneuraminic acid and n-glycollylneuraminic acid ) and colominic acid ( a polymer of n-acetylneuraminic acid ) were the best competito... | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
165,
177
]
} | {
"id": "C0067762",
"name": "n-acetylneuraminic",
"pos": [
271,
289
]
} |
when rabbits are fed on a cholesterol-rich diet , liver ldl receptors can not be detected , consistent with the suppression of hepatic ldl receptors by cholesterol feeding . | NA | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
26,
37
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
152,
163
]
} |
when excess albumin was present , conditions were found ( 90 micrograms of cyclofenil diphenol and 4 mg of albumin per ml of culture medium ) which completely inhibited [ 35s ] proteoglycan and [ 3h ] hyaluronate synthesis but had little effect on [ 3h ] protein or [ 3h ] glycoprotein synthesis . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
12,
19
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
278,
285
]
} |
endopeptidase-24.11 ( ec 3.4.24.11 ) , purified to homogeneity from pig kidney , was shown to hydrolyse a wide range of neuropeptides , including enkephalins , tachykinins , bradykinin , neurotensin , luliberin and cholecystokinin . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
120,
133
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
187,
198
]
} |
if metabolism aids porphyrin elimination , tumours , unlike normal tissues , may not metabolize porphyrins used clinically , such as proto- , haemato- , oo'-diacetyl-haemato- and monohydroxyethyl-monovinyl-deutero-porphyrin . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
3,
13
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
29,
40
]
} |
this work completes the sequence of a 9897 base-pair segment of dna containing seven tricarboxylic acid cycle genes encoding three enzymes or enzyme complexes , citrate synthase ( glta ) , succinate dehydrogenase ( sdh ) , and the 2-oxoglutarate dehydrogenase complex ( suc ) , that are organized thus : glta-sdhcdab-suc... | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
131,
138
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
142,
148
]
} |
less than 20 % of the total inositol phosphate corresponded to inositol 1-phosphate by ion-exchange chromatography , whereas of the remainder about two-thirds corresponded to inositol bisphosphate and one third to inositol trisphosphate . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
28,
46
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
214,
222
]
} |
at physiological temperature , the fluidity of dipalmitoyl phosphatidylcholine was relatively low , but could be markedly increased by the presence of 1-palmitoyl-2-oleoyl phosphatidylcholine or phosphatidylglycerol ( 10 % ) . | NA | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
47,
58
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
172,
191
]
} |
these studies indicate that the unsaturated phosphatidylcholines could play a major role in determining the fluidity of the important surface-tension-lowering phospholipids such as dipalmitoyl phosphatidylcholine . | NA | {
"id": "C1959616",
"name": "phosphatidylcholines",
"pos": [
44,
64
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
181,
192
]
} |
incorporation of radioactivities into different phospholipid fractions of rbc membrane increased on ep treatment to starved rats , whereas , the relative percentages of these phospholipids ( except lpc ) remained more or less unchanged under similar conditions . | NA | {
"id": "C0771648",
"name": "phospholipid fractions of",
"pos": [
48,
73
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
175,
188
]
} |
determinations of total cellular cholesterol gave similar ratios of cholesterol/protein and cholesterol/phospholipid in the huntington 's disease and control fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
24,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
158,
169
]
} |
the nucleolar acid phosphoprotein phosphatase is a very basic protein ( pi 8.3 ) and shows maximal activity at ph 5.8 . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
19,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
62,
69
]
} |
the effects of insulin-like growth factors ( igf-i and ii ) were compared with those of insulin in porcine granulosa cells in vitro with regard to stimulation of thymidine incorporation , facilitation of fsh-induced progesterone secretion , and displacement of [ 125i ] igf-i from specific receptors . | NA | {
"id": "C0037657",
"name": "insulin-like growth factors",
"pos": [
15,
42
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
270,
275
]
} |
the tumor-promoting phorbol ester pma increased the incorporation of 32p-phosphate into pip ( 150 % ) and pip2 ( 50 % ) in human platelets over the same range of concentrations that stimulate protein kinase c activity ( i.e . 1-10 ng/ml ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
20,
33
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
34,
37
]
} |
these two arginine residues presumably function as the recognition site for the anionic 2'-phosphate group of nadp+ . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
80,
87
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
91,
100
]
} |
half-maximal effects are obtained at about 1 microm gtp , 2 microm gdp and 10 microm gpp ( nh ) p ( guanyl-5'-yl-imidodiphosphate ) ; | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
52,
55
]
} | {
"id": "C0018366",
"name": "guanyl-5",
"pos": [
100,
108
]
} |
in this investigation , a number of synthetic uracil and thymine nucleosides which differ from the physiological nucleosides , uridine , deoxyuridine and thymidine , through structural changes at the 2'- and 3'-positions were studied . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
46,
52
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
57,
64
]
} |
1- ( beta-d-arabinofuranosyl ) uracil ( arau ) and 1- ( beta-d-arabinofuranosyl ) thymine ( arat ) were comparable to thymidine as permeants while nucleosides in which the 3'-hydroxyl was replaced with hydrogen or a halogen had a decreased affinity for the transporter . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
31,
37
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
82,
89
]
} |
the flavonols , quercetin and fisetin , and the flavone , apigenin , exhibited a predilection to inhibit histamine release stimulated by ige-dependent ligands ( antigen , anti-ige , and con a ) . | NA | {
"id": "C0060444",
"name": "flavonols",
"pos": [
4,
13
]
} | {
"id": "C0034392",
"name": "quercetin",
"pos": [
16,
25
]
} |
furthermore , the uptake of glycylglycine , a typical dipeptide , was inhibited by cyclacillin , cefadroxil , cephalexin , and cephradine . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
97,
107
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
110,
120
]
} |
furthermore , the uptake of glycylglycine , a typical dipeptide , was inhibited by cyclacillin , cefadroxil , cephalexin , and cephradine . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
110,
120
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
127,
137
]
} |
nifurtimox and benznidazole inhibited gssg-reductase , but not gsh-peroxidase , the former inhibition contributing to gsh depletion . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
38,
42
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
118,
121
]
} |
the membrane-bound carboxypeptidase activity had a neutral ph optimum and behaved similarly to plasma carboxypeptidase n in the presence of various inhibitors and activators . | NA | {
"id": "C0007075",
"name": "carboxypeptidase",
"pos": [
19,
35
]
} | {
"id": "C0003766",
"name": "carboxypeptidase n",
"pos": [
102,
120
]
} |
since chlorine placement and the degree of chlorination of the biphenyl nucleus play an important role in the metabolism and ultimate elimination of polychlorinated biphenyls ( pcbs ) , we have studied the metabolism of 4,4'-dichlorobiphenyl ( 4-dcb ) by human hepatic microsomes . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
134,
145
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
206,
216
]
} |
these findings confirm the assumption , made earlier on the basis of conformational analysis of ( gly-pro-hyp ) n , ( gly-pro-ala ) n , ( gly-ala-hyp ) n , ( gly-ala-ala ) n , that the collagen triple helix contains stable wound triplets with proline in the second position , while the absence of imino acid in the 2nd p... | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
243,
250
]
} | {
"id": "C0020931",
"name": "imino acid",
"pos": [
297,
307
]
} |
cd and fluorescence methods were used to monitor the complex formation between rifamycin sv or its derivative , rifampicin , with the rna polymerase from the e. coli wild and mutant ( rpo b255 ) types , the former enzyme being sensitive and the latter being resistant to these antibiotics . | NA | {
"id": "C0035609",
"name": "rifamycin sv",
"pos": [
79,
91
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
112,
122
]
} |
its spatial structure was shown to be dependent on the hemoglobin state prior to the s-s bond formation : a disulfide made with deoxyhemoglobin had more closely interwoven hemoglobin and glutathione chains than the methemoglobin-derived disulfide . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
55,
65
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
215,
228
]
} |
synthesis of blood group abh ( type 1 ) determinant oligosaccharides and leb tetrasaccharide has been performed using the same trisaccharide precursor-benzyl 2-acetamido-4,6-o-benzylidene- [ 4,6-o-benzylidene-2-o- [ 2-o-benzyl-3,4-di- o- ( 4-nitrobenzoyl ) -alpha-l-fucopyranosyl ] -beta-d-galactopyranosyl ] -2-deoxy - ... | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
52,
68
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
127,
140
]
} |
the high affinity site does not discriminate the divalent and trivalent metal ions : all examined cations enhanced the enkephalin affinity for this site . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
78,
82
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
98,
105
]
} |
although hla-dr3 was significantly increased in whites ( 25 of 50 , 50 % ) and blacks ( 4 of 5 , 80 % ) with primary ss compared with race-matched normal controls , it was not appreciably elevated in those with systemic lupus erythematosus ( sle ) -ss , rheumatoid arthritis ( ra ) -ss , or connective tissue disease-ss ... | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
254,
274
]
} | {
"id": "C1527336",
"name": "ss",
"pos": [
317,
319
]
} |
the mt2 specificity , however , was more strongly associated with primary ss ( 86 % of whites and 100 % of blacks ) and also with sle-ss and ra-ss compared with race-matched normal controls . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
141,
143
]
} | {
"id": "C1527336",
"name": "ss",
"pos": [
144,
146
]
} |
furthermore , mt2 was significantly increased in sle-ss and ra-ss when compared with non-sicca sle and ra controls . | NA | {
"id": "C1527336",
"name": "ss",
"pos": [
53,
55
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
103,
105
]
} |
the acute toxicity of cyclophosphamide ( cp ) was investigated following the pretreatment with seven sulfur-containing compounds ( scc ) : disulfiram ( dsf ) , diethyldithiocarbamate ( ddtc ) , l-cysteine ( cys ) , n-acetyl-l-cysteine ( ac-cys ) , s-carboxymethyl-l-cysteine ( carb-cys ) , d-penicillamine ( pen ) , and ... | NA | {
"id": "C0001047",
"name": "n-acetyl-l-cysteine",
"pos": [
215,
234
]
} | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
264,
274
]
} |
the following ld50 values were recorded : cp alone 254 , cp + dsf 77 , cp + ddtc 260 , cp + cys 345 , cp + ac-cys 319 , cp + carb-cys 271 , cp + pen 392 , cp + c-nh 299 mg/kg b.wt . | NA | {
"id": "C0001047",
"name": "ac-cys",
"pos": [
107,
113
]
} | {
"id": "C0010654",
"name": "carb-cys",
"pos": [
125,
133
]
} |
the blocking effects of metacaine-methanesulfonate ( ms-222 ; abbreviated mms ) and of the corresponding hydrochloride ( mhc ) on the ionic currents in potential clamped myelinated nerve fibres were investigated . | NA | {
"id": "C0025619",
"name": "methanesulfonate",
"pos": [
34,
50
]
} | {
"id": "C0025706",
"name": "mms",
"pos": [
74,
77
]
} |
the multiplicity of opioid peptides ( endorphins ) present in the mammalian cns finds a counterpart in the existence of various types of opioid receptors ( mu , delta , kappa , epsilon ) . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
20,
35
]
} | {
"id": "C0014242",
"name": "endorphins",
"pos": [
38,
48
]
} |
the epidural opiate analgesia has proven good results with few side effects in the treatment of postoperative pain , pain of multiple rib fractures and other thoracic trauma or cancer pain . | NA | {
"id": "C0030201",
"name": "postoperative pain",
"pos": [
96,
114
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
184,
188
]
} |
the epidural opiate analgesia has proven good results with few side effects in the treatment of postoperative pain , pain of multiple rib fractures and other thoracic trauma or cancer pain . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
110,
114
]
} | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
177,
188
]
} |
cholestyramine produced a 17.4 % fall in low density lipoprotein ( ldl ) cholesterol , no significant changes in very low density lipoprotein ( vldl ) cholesterol or high density lipoprotein ( hdl ) cholesterol , a 21.4 % increase in hdl cholesterol subfraction hdl2 and a 24.1 % increase in the hdl/ldl cholesterol rati... | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
234,
249
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
304,
315
]
} |
probucol produced a 11.7 % fall in ldl cholesterol , a 9.9 % fall in vldl cholesterol , a 10 % fall in total hdl cholesterol , a 37 % fall in hdl cholesterol subfraction hdl2 and no change in the hdl/ldl cholesterol ratio . | NA | {
"id": "C0023826",
"name": "vldl",
"pos": [
69,
73
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
204,
215
]
} |
probucol produced a 11.7 % fall in ldl cholesterol , a 9.9 % fall in vldl cholesterol , a 10 % fall in total hdl cholesterol , a 37 % fall in hdl cholesterol subfraction hdl2 and no change in the hdl/ldl cholesterol ratio . | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
109,
124
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
204,
215
]
} |
cholestyramine has a more marked effect on ldl cholesterol , favourably influences the hdl/ldl cholesterol ratio and is therefore considered to be the drug of choice . | NA | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
43,
58
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
95,
106
]
} |
about two thirds of the cases were under the influence of alcohol with a mean blood alcohol concentration of 1.6 g/l . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
58,
65
]
} | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
78,
105
]
} |
two-fifths of the alcohol consumed by women was in the form of wine and three-fifths consumed by men was in the form of beer . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
18,
25
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
63,
67
]
} |
two-fifths of the alcohol consumed by women was in the form of wine and three-fifths consumed by men was in the form of beer . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
18,
25
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
120,
124
]
} |
it is concluded that these two fractions of the enzyme must contain different subsets of the eight isoenzymes of transketolase of differing isoelectric points and that some of these isoenzymes must differ also in their affinity for the coenzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
48,
54
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
182,
192
]
} |
the prevention of alcohol poisoning in the young child consists in protecting the alcohol by lock and key , not setting an example by drinking or gargling in front of children . | NA | {
"id": "C0728836",
"name": "young child",
"pos": [
43,
54
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
167,
175
]
} |
once actual poisoning has occurred blood sugar is probably more important than the level of blood ethanol and blood sugar levels should be monitored frequently and the child treated with glucose , preferably intravenously . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
35,
46
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
187,
194
]
} |
this physiological study of regional myocardial perfusion in patients in hospital and in those with ischaemia out of hospital showed that three different mechanisms may account for the relief of pain -- improved perfusion , infarction , and silent ischaemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
224,
234
]
} | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
248,
257
]
} |
clindamycin and lincomycin kill staphylococci relatively slowly , particularly in cell culture medium and balanced salt solution . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
0,
11
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
16,
26
]
} |
this suggests that there are two phases in the response of the epidermal ia antigens in contact sensitivity reactions , i.e . an early phase in which enlarged langerhans cells are the only ia-positive cells in the epidermis , and a late phase in which keratinocytes take over as the major ia-positive cells , while lange... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
19,
22
]
} | {
"id": "C0022567",
"name": "take",
"pos": [
266,
270
]
} |
seven patients with porphyria cutanea tarda received a total of ten courses of low-dose oral chloroquine therapy ( 125 mg chloroquine phosphate twice weekly ) . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
93,
104
]
} | {
"id": "C0055447",
"name": "chloroquine phosphate",
"pos": [
122,
143
]
} |
seven patients had long-standing arthropathy serologically proven to be rheumatoid arthritis and these had previously been considered to have felty 's syndrome . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
72,
92
]
} | {
"id": "C0015773",
"name": "felty 's",
"pos": [
142,
150
]
} |
these originated from nine natural minerals , anthophyllite and chrysotile asbestos , talc , and quartz , feldspars , and muscovite , which are components of sand , and also from two artificial mullites used in fire clay . | NA | {
"id": "C0026162",
"name": "minerals",
"pos": [
35,
43
]
} | {
"id": "C0037098",
"name": "sand",
"pos": [
158,
162
]
} |
these originated from nine natural minerals , anthophyllite and chrysotile asbestos , talc , and quartz , feldspars , and muscovite , which are components of sand , and also from two artificial mullites used in fire clay . | NA | {
"id": "C0034387",
"name": "quartz",
"pos": [
97,
103
]
} | {
"id": "C0037098",
"name": "sand",
"pos": [
158,
162
]
} |
two groups of rats were exposed to quartz dust for six months and in addition one group was given drinking water containing 1.5 % sodium glutamate while the second received only water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
98,
112
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
178,
183
]
} |
a biological monitoring programme has been developed for assessing occupational exposure to 4,4'-methylenebis ( 2-chloroaniline ) ( mboca ) in a factory which manufactures polyurethane elastomers . | NA | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
172,
184
]
} | {
"id": "C0013766",
"name": "elastomers",
"pos": [
185,
195
]
} |
from a comparison of the specific activities of the amino acids and of carbon dioxide in blood during the course of the experiments , it was found that in the fetuses 0.96 % of the co2 present in blood was derived from alanine and only 0.12 % was derived from glycine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
52,
63
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
219,
226
]
} |
from a comparison of the specific activities of the amino acids and of carbon dioxide in blood during the course of the experiments , it was found that in the fetuses 0.96 % of the co2 present in blood was derived from alanine and only 0.12 % was derived from glycine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
52,
63
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
260,
267
]
} |
purification of the beta-adrenergic receptor has also been assessed by silver staining , iodinated lectin binding , and measurement of the specific activity ( approximately 15 000 pmol of [ 3h ] dihydroalprenolol bound/mg of protein ) . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
99,
105
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
225,
232
]
} |
we have found correlations between rate constants and the difference in redox potential of the reactants for electron-transfer reactions between oxidized cytochromes and either photoproduced riboflavin or flavin mononucleotide ( fmn ) semiquinones ( the latter rate constants extrapolated to infinite ionic strength ) . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
191,
201
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
229,
232
]
} |
transition from the right-handed b to the left-handed z conformation of dna was studied by circular dichroism in parallel with the ability of the dna to support rna synthesis with escherichia coli rna polymerase . | NA | {
"id": "C0043442",
"name": "z",
"pos": [
54,
55
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
146,
149
]
} |
model membranes of egg phosphatidylcholine , dimyristoyl- ( dmpc ) , dipalmitoyl- ( dppc ) and distearoyl- ( dspc ) phosphatidylcholines , and native membranes of mitochondria , sarcoplasmic reticulum , brain microsomes , myelin and erythrocytes were investigated . | NA | {
"id": "C0012456",
"name": "dmpc",
"pos": [
60,
64
]
} | {
"id": "C1959616",
"name": "phosphatidylcholines",
"pos": [
116,
136
]
} |
the delta u dependence on the m-protein and neuraminidase concentration indicates different mechanisms of adsorption of these viral proteins by the lipid bilayer . | NA | {
"id": "C0033684",
"name": "m-protein",
"pos": [
30,
39
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
126,
131
]
} |
in dictyostelium discoideum , ( n-acyl ) ethanolamine glycerophospholipids disappear as the amoebae aggregate , whereas the amount of ethanolamine glycerophospholipids remains relatively constant , suggesting that each type of ethanolamine-containing phospholipid might have a separate metabolic pathway . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
54,
74
]
} | {
"id": "C0031618",
"name": "ethanolamine",
"pos": [
227,
239
]
} |
the extent of glycans heterogeneity in a pathological human immunoglobulin m zaj has been studied on oligosaccharides released by hydrazinolysis from the purified glycoprotein . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
14,
21
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
101,
117
]
} |
somatostatin exhibited competitive inhibition of tracer binding , while neuropeptides such as neurotensin , substance p , leu-enkephalin , and vasoactive intestinal peptide were ineffective . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
72,
85
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
94,
105
]
} |
the effects of colchicine and vincristine on the concentration of glucose and its metabolites in milk were studied following intramammary injection of the alkaloids into one mammary gland of lactating goats . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
15,
25
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
155,
164
]
} |
magnesium and manganese ions bind strongly to the unusual transfer rna anticodon loop nucleotides , n- [ ( 9-beta-d-ribofuranosyl-9h-purin-6-yl ) carbamoyl ] -l-threonine 5'-monophosphate ( pt6a ) and uridine-5-oxyacetic acid 5'-monophosphate ( pv ) . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
58,
70
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
71,
80
]
} |
changes in activities of a new proteinase cathepsin t as well as some other lysosomal acid proteinases and hydrolases were examined in liver homogenate from rats treated with a single hepatotoxic dose of carbon tetrachloride . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
91,
102
]
} | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
107,
117
]
} |
as judged from the molecular weights , the elevated activities of cathepsins t and d in the treated rat liver could be attributable to the two cathepsins themselves and not to other proteinases . | NA | {
"id": "C0007428",
"name": "cathepsins",
"pos": [
66,
76
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
182,
193
]
} |
to evaluate the influence of cell density on the activity of fibroblast prolidase ( ec 3.4.13.9 ) , we determined this activity in sparse and dense cultures . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
12,
15
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
61,
71
]
} |
it was shown that rrna and hnrna synthesis in rat liver nuclei does not change-within 30 min after intraperitoneal injection of acetylcholine ( 0.005 mg per 100 g of body weight ) but decreases after injection of norepinephrine and epinephrine ( 0.05 mg per 100 g of body weight ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
213,
227
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
232,
243
]
} |
creatine and creatinine serve as indices of one aspect of brain energy metabolism , the creatine-creatine phosphate ( crp ) shuttle . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
0,
8
]
} | {
"id": "C0031634",
"name": "creatine",
"pos": [
97,
105
]
} |
there was a statistically significant increase in well-being following d-amphetamine as compared to baseline and placebo on both the amphetamine interview rating scale and the hopkins mood scale . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
71,
84
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
133,
144
]
} |
j. , 36:623-651 ) is presented for the adsorption of monovalent and divalent cations by single-component phospholipid membranes , where monovalent cations adsorb with a cation/phospholipid stoichiometry of 1:1 and divalent cations adsorb with stoichiometries of 1:1 and 1:2 . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
136,
154
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
223,
229
]
} |
j. , 36:623-651 ) is presented for the adsorption of monovalent and divalent cations by single-component phospholipid membranes , where monovalent cations adsorb with a cation/phospholipid stoichiometry of 1:1 and divalent cations adsorb with stoichiometries of 1:1 and 1:2 . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
77,
83
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
214,
230
]
} |
also it is shown how the release of ions is affected by the concentration of the electrolyte within the electrode and that of the external solution . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
36,
40
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
81,
92
]
} |
the oxygen quenching of a ternary complex of ladh , nad+ and trifluoroethanol was also studied . | NA | {
"id": "C0001962",
"name": "ladh",
"pos": [
45,
49
]
} | {
"id": "C0040983",
"name": "trifluoroethanol",
"pos": [
61,
77
]
} |
catalytic influence of heparin on auramine o hydrolysis : a basis for differentiating heparin from other glycosaminoglycans based on its properties as a polyelectrolyte . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
23,
30
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
105,
123
]
} |
cytosols were centrifuged on 5-20 % sucrose gradients after labeling with tritiated 1,25 ( oh ) 2d3 ( 3h-1,25 ( oh ) 2d3 or 25-hydroxyvitamin d3 ( 25 ( oh ) d3 alone or in the presence of a large excess of these unlabeled sterols . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
124,
144
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
147,
159
]
} |
mda may also alter protein configuration , as evidenced by an increase in the protease susceptibility of membrane proteins from mda-treated and hb koln rbcs . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
19,
26
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
105,
122
]
} |
there were no postoperative deaths in 61 patients in whom stricture repair alone was performed by direct suture techniques , but in the presence of portal hypertension and liver disease the mortality was 27 per cent . | NA | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
148,
167
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
172,
185
]
} |
factors influencing mortality were the number of previous operations , a history of major infection , the site of stricture , pre-operative serum albumin concentration , and the presence of liver disease and portal hypertension . | NA | {
"id": "C0023895",
"name": "the",
"pos": [
35,
38
]
} | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
208,
227
]
} |
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