text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
together , these dopamine , epinephrine and norepinephrine systems are believed to ascend into the medial aspect of the medial forebrain bundle on their way to the pfh at the level of the ventromedial nucleus . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
28,
39
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} |
when cultured cells are permeabilized with denaturing agents , s1 antibody not only labels cell surfaces of some glial cells and , depending on the developmental stage , some neuronal cells but also intracellular components of all astrocytes , oligodendrocytes , neurons and fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
14,
18
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
275,
286
]
} |
and , the anticonvulsant action of the l-isomer of the adenosine analogue phenylisopropyladenosine ( pia ) is substantially more potent than the d-isomer , findings which are characteristic of an a1 type adenosine receptor . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
55,
64
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
74,
98
]
} |
it is suggested that the immunostimulation elicited by heating and cooling the preoptic area , and by inference that the immunostimulation associated with fever , could be due to factors other than the change in body temperature . | NA | {
"id": "C0015967",
"name": "fever",
"pos": [
155,
160
]
} | {
"id": "C0005904",
"name": "change",
"pos": [
202,
208
]
} |
like other opioid peptides that have been studied in this species , d-ala2-d-leu5-enkephalin ( 5-25 micrograms ) induced a dose-related hyperthermia . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
11,
26
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
82,
92
]
} |
high performance liquid chromatography indicated the occurrence of noradrenaline , adrenaline , dopamine and serotonin within the ap . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
67,
80
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
83,
93
]
} |
a thin-layer chromatographic assay for separation of amino acid neurotransmitters was used to estimate the content in each sample of perfusate of labeled gamma-amino-butyric acid ( gaba ) , glutamate , glutamine , aspartate and glycine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
53,
58
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
228,
235
]
} |
the results show that recovery of three amino acids , gaba , aspartate and glycine , was uniform among the three areas of the rat 's cortex . | NA | {
"id": "C0002520",
"name": "gaba",
"pos": [
54,
58
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
75,
82
]
} |
overall , the recovery of gaba was proportionally higher whereas glycine was lower than that of the other amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
65,
72
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
106,
111
]
} |
this is a new type of dna lesion induced in dna by an intercalating agent . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
44,
47
]
} |
statistically significant increases in both epinephrine and norepinephrine concentrations were observed during the immediate postoperative period in group i patients only . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
44,
55
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
gdp-beta-s and gtp were found to be equally potent in inhibiting gpp ( nh ) p-activated adenylate cyclase activity in both groups . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
15,
18
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
65,
77
]
} |
two previously unidentified apolipoproteins ( apo ) designated apo c-ii-x and c-ii-y have been found in plasma of homozygotes and obligate heterozygotes of a family with apo c-ii deficiency . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
28,
43
]
} | {
"id": "C0003594",
"name": "apo c",
"pos": [
170,
175
]
} |
in spite of the extensive changes in cell shape and motility associated with blastocyst outgrowth , a common set of putative maps characterizes the two stages investigated , including several in the size range of tau factors . | NA | {
"id": "C0026045",
"name": "maps",
"pos": [
125,
129
]
} | {
"id": "C0085401",
"name": "tau factors",
"pos": [
213,
224
]
} |
budr ( 5-bromo , 2-deoxyuridine ) labelled metaphases from three men were utilized to determine the cell cycle kinetics in the medium used . | NA | {
"id": "C0006233",
"name": "budr",
"pos": [
0,
4
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
19,
31
]
} |
taurine and glycine , the amino acids present in the conjugated bile acids , were injected i.v . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
12,
19
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
26,
37
]
} |
mean basal values for hepatic venous na , adrenaline , dopamine , and gl were 0.062 , 0.022 , 0.032 ng/ml , and 97.9 mg % , respectively . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
37,
39
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
42,
52
]
} |
in rats chronically fed a fiber-free diet or one of the three nutritionally equivalent fiber-containing diets , in vivo jejunal absorption of l-leucine from a free amino acid mixture of l-leucine and glycine as well as equimolar solutions of the dipeptides , l-leucyl-glycine and glycyl-l-leucine , were compared . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
164,
174
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
268,
275
]
} |
these results confirm the importance of ca2+ ions in contractile and electrical cardiac functions and show that decreased availability of this cation leads to increasing enzyme leakage resembling that seen in ver-treated hearts . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
45,
49
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
143,
149
]
} |
the effect of varying doses ( 10 ( -8 ) and 10 ( -6 ) m ) of natural glucocorticoids ( corticosterone , cortisol ) or synthetic glucocorticoids ( triamcinolone , triamcinolone acetonide , betamethasone , dexamethasone ) and that of a synthetic progestin ( r-5020 ) on cultured leydig cells was also studied . | NA | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
146,
159
]
} | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
162,
185
]
} |
the ability of isosorbide dinitrate ( isdn ) and its two metabolites , 5-isosorbide mononitrate ( 5-ismn ) and 2-isosorbide mononitrate ( 2-ismn ) , to relax phenylephrine-contracted rabbit aortic rings was compared . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
15,
35
]
} | {
"id": "C0064079",
"name": "isosorbide mononitrate",
"pos": [
113,
135
]
} |
isdn was found to be the most potent ( median effective dose ( ed50 ) ; 1.5 x 10 ( -7 ) +/- 1.1 x 10 ( -7 ) m ) , followed by 2-ismn ( ed50 , 1.8 x 10 ( -6 ) +/- 9 x 10 ( -7 ) m ) and 5-ismn ( ed50 , 8.2 x 10 ( -6 ) +/- 3.6 x 10 ( -6 ) m ) . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
0,
4
]
} | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
184,
190
]
} |
it is concluded that in rabbit aortic rings 5-ismn , the major metabolite of isdn , is not an antagonist of isdn at a `` '' nitrate receptor , '' '' and no support is provided for the hypothesis that the accumulation in plasma of metabolites ( e.g. , 5-ismn ) with longer half-lives than the parent drug explains toleran... | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
77,
81
]
} | {
"id": "C0064079",
"name": ", 5-is",
"pos": [
249,
255
]
} |
some key properties of the binding of [ 3h ] nitrendipine , an analogue of the 1,4-dihydropyridine , nifedipine , to a plasma membrane enriched microsomal fraction from the rat liver are described . | NA | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
45,
57
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
83,
98
]
} |
some key properties of the binding of [ 3h ] nitrendipine , an analogue of the 1,4-dihydropyridine , nifedipine , to a plasma membrane enriched microsomal fraction from the rat liver are described . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
83,
98
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
101,
111
]
} |
inhibition of binding was specific for dihydropyridines with competitive inhibition being noted with nifedipine and 4-chloronifedipine , as well as bay k-8644 , a calcium channel agonist . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
39,
55
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
124,
134
]
} |
a new wild-type isolate of epstein-barr virus ( ebv ) was identified in follow-up studies of a case of chronic active ebv infection in an 8-year-old girl who had high titres of antibody to viral capsid antigen and early antigen ( ea ) ( greater than 20 480 and 2560 respectively ) , persistent splenomegaly and abnormal ... | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
189,
194
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
220,
227
]
} |
in addition , the potential for biologic response modifiers or the biologic products of normal cells that are normally involved in the regulation of both proliferation and differentiation show enormous potential for the treatment of advanced disease . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
14,
17
]
} | {
"id": "C0005522",
"name": "biologic products",
"pos": [
67,
84
]
} |
monoclonal antibody b6.2 , which recognizes a 90,000-d glycoprotein , was radiolabeled and shown to efficiently localize human carcinoma transplants in athymic mice via gamma imaging without the use of second antibody or background subtraction manipulations . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
0,
19
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
209,
217
]
} |
the ability of a `` '' tumor-specific ' , monoclonal antibody ( ox7 ) and a subclass-matched , non-specific , control antibody ( anti hrp ) to localize in and image small ( 20-60 mg ) murine lymphomas growing in the subrenal capsule of mice was tested . | NA | {
"id": "C0003250",
"name": "monoclonal antibod",
"pos": [
42,
60
]
} | {
"id": "C0003241",
"name": "antibod",
"pos": [
53,
60
]
} |
the first , transforming growth factors ( tgf 's ) confer a transformed phenotype on non-transformed fibroblasts while the second , tumor inhibitory factors ( tif 's ) , inhibits the anchorage independent growth of transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
101,
112
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
179,
182
]
} |
bile acids exerted marked cytotoxicity on the cells at concentrations of greater than 100 microm lithocholic acid or deoxycholic acid , greater than 150 microm chenodeoxycholic acid , and greater than 500 microm cholic acid . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
117,
133
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
160,
181
]
} |
coadministration of 50 microm uridine prevented depletion of pyrimidine nucleoside triphosphates and inhibition of colony formation of hl-60 cells exposed to 3 mm n- ( phosphonacetyl ) -l-aspartate ) or 5 x 10 ( -6 ) m pyrazofurin but was not capable of protecting hl-60-5-azacytidine under the same conditions . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
30,
37
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleoside",
"pos": [
61,
82
]
} |
compounds containing a daunosamine sugar moiety ( adriamycin , daunomycin , 4-demethoxydaunomycin , 4-demethoxyadriamycin , and carminomycin ) were highly active in both mutagenesis assays . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
63,
73
]
} | {
"id": "C0020789",
"name": "4-demethoxydaunomycin",
"pos": [
76,
97
]
} |
compounds containing a daunosamine sugar moiety ( adriamycin , daunomycin , 4-demethoxydaunomycin , 4-demethoxyadriamycin , and carminomycin ) were highly active in both mutagenesis assays . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
63,
73
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
128,
140
]
} |
this antibiotic was preferentially toxic to emt6 mouse mammary tumor cells and v79 chinese hamster lung fibroblasts under hypoxic conditions , but it was equitoxic to chinese hamster ovary cells in the presence and absence of oxygen . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
104,
115
]
} |
the in vitro ifn sensitivity of these three tumors was not consistent with the in vivo therapeutic response in mice bearing these tumors under the present experimental conditions ; | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
44,
50
]
} | {
"id": "C0027659",
"name": "tumors",
"pos": [
130,
136
]
} |
three of the monoclonal antibodies produced were immunoglobulin g1 isotype , while two were immunoglobulin m . | NA | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
49,
63
]
} | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
92,
108
]
} |
two of the monoclonal antibodies recognized adjacent epitopes on the enzyme molecule , two antibodies recognized two other unique epitopes , while the epitope recognized by the fifth was uncertain . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
11,
32
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
91,
101
]
} |
no localization was seen in mice bearing a b72.3 antigen-negative human melanoma xenograft or with an isotype-identical control immunoglobulin g in mice bearing colon tumor xenografts . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
102,
109
]
} | {
"id": "C0020852",
"name": "immunoglobulin g",
"pos": [
128,
144
]
} |
diethyldithiocarbamate , potassium cyanide ( kcn ) , sodium thiocyanate , l-methionine , n-acetyl-l-cysteine , 2-aminoethanethiol , l-cysteine , l-lysine , l-histidine , and l-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum ( ii ) -protein binding ... | NA | {
"id": "C0001047",
"name": "n-acetyl-l-cysteine",
"pos": [
89,
108
]
} | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
132,
142
]
} |
patients with chronic lymphocytic leukemia , cutaneous t-cell lymphoma , or t-cell lymphoma have received 24-hr infusions of 3 to 500 mg t101 in therapeutic trials . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell",
"pos": [
45,
61
]
} | {
"id": "C0079772",
"name": "t-cell lymphoma",
"pos": [
76,
91
]
} |
a combination chemotherapy program using methotrexate , bleomycin , doxorubicin , cyclophosphamide , vincristine , and dexamethasone ( m-bacod ) , which resulted in a high complete response rate and prolonged disease-free survival in lymphomas of the unfavorable diffuse histiocytic and diffuse undifferentiated histopat... | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
423,
447
]
} | {
"id": "C0024301",
"name": "nodular lymphoma",
"pos": [
460,
476
]
} |
vinzolidine is an active vinca alkaloid which merits further evaluation in patients with lymphoma , particularly hodgkin 's disease . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
89,
97
]
} | {
"id": "C0019829",
"name": "hodgkin 's",
"pos": [
113,
123
]
} |
structural studies of the o-antigen of the lipopolysaccharide from an avirulent strain ( m4s ) of pseudomonas solanacearum . | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
26,
35
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
43,
61
]
} |
accordingly formation of ethanol , indicative of ethoxy group elimination , could be observed during p-phenetidine metabolism . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
62,
73
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
115,
125
]
} |
in addition , maleate lowered both intracellular and extracellular glutathione levels and enhanced sensitivity of tuwi cells to azaserine , while serine-borate , a potent inhibitor of ggt , increased extracellular glutathione levels and inhibited azaserine toxicity . | NA | {
"id": "C0036720",
"name": "serine",
"pos": [
131,
137
]
} | {
"id": "C0004480",
"name": "azaserine",
"pos": [
247,
256
]
} |
the concentrations , [ ci ] 5 of each alcohol that decrease the membrane 2t ' value by 5 % , vary by a factor of 1500 from methanol to octanol . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
38,
45
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
123,
131
]
} |
varying concentrations of ellagic acid added to the keratinocyte cultures resulted in a dose-dependent inhibition of the cytochrome p-450-dependent monooxygenases aryl hydrocarbon hydroxylase ( ahh ) and 7-ethoxycoumarin-o-deethylase ( ecd ) . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
163,
191
]
} | {
"id": "C0000644",
"name": "7-ethoxycoumarin-o-deethylase",
"pos": [
204,
233
]
} |
adducts formed by reaction of 1'-acetoxysafrole , a model ultimate carcinogen , with mouse-liver dna in vitro were chromatographically identical to safrole-dna adducts formed in vivo . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
97,
100
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
156,
167
]
} |
ethinyl estradiol , the estrogenic component of oral contraceptives , has been shown to enhance the mutagenicity of 2-aminofluorene , 2-acetylaminofluorene , n-hydroxy-2-acetylaminofluorene , and n-acetoxy-2-acetylaminofluorene with strain ta 98 of salmonella typhimurium and various rat liver activating systems . | NA | {
"id": "C0000248",
"name": "2-acetylaminofluorene",
"pos": [
134,
155
]
} | {
"id": "C0020319",
"name": "n-hydroxy-2-acetylaminofluorene",
"pos": [
158,
189
]
} |
ethinyl estradiol , the estrogenic component of oral contraceptives , has been shown to enhance the mutagenicity of 2-aminofluorene , 2-acetylaminofluorene , n-hydroxy-2-acetylaminofluorene , and n-acetoxy-2-acetylaminofluorene with strain ta 98 of salmonella typhimurium and various rat liver activating systems . | NA | {
"id": "C0000248",
"name": "2-acetylaminofluorene",
"pos": [
134,
155
]
} | {
"id": "C0001011",
"name": "n-acetoxy-2-acetylaminofluorene",
"pos": [
196,
227
]
} |
the specificity of 15 monoclonal antibodies to myosin heavy chains was assessed by the reactivity of muscle extracts and of chymotryptic myosin fragments of different sizes with these antibodies , as determined by the immune replicate technique ; | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
22,
43
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
184,
194
]
} |
the specificity of 15 monoclonal antibodies to myosin heavy chains was assessed by the reactivity of muscle extracts and of chymotryptic myosin fragments of different sizes with these antibodies , as determined by the immune replicate technique ; | NA | {
"id": "C0027100",
"name": "myosin heavy chains",
"pos": [
47,
66
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
137,
143
]
} |
some of the monoclonal antibodies cross-reacted only with the ventricular v3-type myosin from hypothyroid rats , whereas the other antibodies cross-reacted both with the latter and with the ventricular v1-type myosins from normal young rats . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
12,
33
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} |
because of the close correspondence observed between the immunological and histochemical responses of atrial fibers , it has been postulated that at least two distinct types of myosin exist in the human atrium , each myosin form being histochemically related to either alpha- or beta-like ventricular myosin heavy chains... | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
177,
183
]
} | {
"id": "C0027100",
"name": "myosin heavy chains",
"pos": [
301,
320
]
} |
the remainder had supraventricular tachycardia due to av node reentry , ectopic atrial tachycardia , or incorporated an accessory pathway . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
18,
46
]
} | {
"id": "C0039234",
"name": "ectopic atrial tachycardia",
"pos": [
72,
98
]
} |
the mean guanase activities for patients with various liver diseases , including acute hepatitis , chronic hepatitis , liver cirrhosis , hepatoma and metastatic carcinoma , were above the upper limit of the reference range . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
54,
68
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
119,
134
]
} |
the patterns for 15 of 20 patients with parkinson 's disease showed a protein ( mr 25 000 ) with charge similar to albumin , which was not seen in the patterns for any of 91 normal volunteers . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
70,
77
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
115,
122
]
} |
we have also shown that glucocorticoids are important in maintaining the overall synthesis of secreted proteins and the protein phenotype of isolated hepatocytes in primary culture . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
81,
90
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
120,
127
]
} |
of the approximately 2000 proteins or protein subunits so resolved from cell lysates and the 450 from membrane extracts of leukocytes from patients with t- and b-cell cll , we were able to identify spots corresponding to the proteins designated by the okt.4 and okt.10 antibodies , the human class i and ii histocompatib... | NA | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
38,
54
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
225,
233
]
} |
such detailed analysis of the plasma apolipoproteins should provide a better understanding of apolipoprotein function and the role these apolipoproteins play in lipoprotein metabolism and the pathophysiology of dyslipoproteinemias and coronary artery disease . | NA | {
"id": "C0003592",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
137,
152
]
} |
the allergic group presented a significantly decreased methyltransferase activity compared with a control group , whereas cyclic amp phosphodiesterase and noradrenaline ( na ) -stimulated methyltransferase were found to be increased with respect to the control group . | NA | {
"id": "C0025831",
"name": "methyltransferase",
"pos": [
55,
72
]
} | {
"id": "C0031397",
"name": "noradrenaline",
"pos": [
155,
168
]
} |
thus , it appears that the degree of desialylation of the sialic acid-rich glycoproteins is a more sensitive index of the severity of hepatic injury than that of the sialic acid-poor glycoproteins . | NA | {
"id": "C0003987",
"name": "desialylation",
"pos": [
37,
50
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
183,
196
]
} |
nitrocellulose blots of normal human plasma proteins separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis were examined for polymeric complexes and fragments of albumin using an immunoperoxidase-labelled mouse monoclonal anti-human albumin antibody . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
179,
186
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
244,
257
]
} |
the interrelationships between the renin-aldosterone system and the sympathetic and dopaminergic activities were studied by measuring the plasma renin activity ( pra ) , plasma aldosterone concentration ( pac ) , serum prolactin ( prl ) concentration , and 24 hr-urinary excretions of adrenaline ( ad ) , noradrenaline (... | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
84,
96
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
330,
338
]
} |
the interrelationships between the renin-aldosterone system and the sympathetic and dopaminergic activities were studied by measuring the plasma renin activity ( pra ) , plasma aldosterone concentration ( pac ) , serum prolactin ( prl ) concentration , and 24 hr-urinary excretions of adrenaline ( ad ) , noradrenaline (... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
285,
295
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
305,
318
]
} |
from these results , it is shown that the renin-aldosterone system has a relation to urinary na excretion , and the existence of an interrelationship between the central dopaminergic activity and urinary da excretion is suggested . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
170,
182
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
204,
206
]
} |
these values overlap the range found for carriers of tay-sachs disease , and suggest that the usefulness of this substrate , while excellent for diagnosing b variants of gm2 gangliosidosis , requires further study . | NA | {
"id": "C0039373",
"name": "tay-sachs",
"pos": [
53,
62
]
} | {
"id": "C0268274",
"name": "gm2 gangliosidosis",
"pos": [
170,
188
]
} |
multiple regression analysis showed that height and weight of both parents and maternal smoking status were associated with variation in birth weight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
52,
58
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
137,
149
]
} |
alpha-l-iduronidase activity was assayed by incubation of a radiolabelled disaccharide , o- ( alpha-l-idopyranosyluronic acid ) - ( 1 -- -- 3 ) -2,5 anhydro-d- [ 1,3h ] -talitol 4-sulfate ( idoa-ant4s ) derived from dermatan sulfate , with homogenates of leucocytes , cultured amniotic cells and skin fibroblasts from no... | NA | {
"id": "C0023786",
"name": "mps i",
"pos": [
440,
445
]
} | {
"id": "C0026703",
"name": "mucopolysaccharidoses",
"pos": [
508,
529
]
} |
the insulin content of ic in insulin treated patients was assessed in vitro by examining , ( a ) the selective precipitation of antibody bound insulin by 3 % polyethylene glycol ( peg ) and ( b ) the insulin specificity of antisera raised against peg precipitates of ic positive sera . | NA | {
"id": "C0003313",
"name": "ic",
"pos": [
23,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
128,
136
]
} |
the insulin content of ic in insulin treated patients was assessed in vitro by examining , ( a ) the selective precipitation of antibody bound insulin by 3 % polyethylene glycol ( peg ) and ( b ) the insulin specificity of antisera raised against peg precipitates of ic positive sera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
128,
136
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
223,
231
]
} |
they seem to be confined to some forms of cardiomyopathies and myocarditis of unknown aetiology and were not detected in sera from patients with other diseases . | NA | {
"id": "C0878544",
"name": "cardiomyopathies",
"pos": [
42,
58
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
63,
74
]
} |
the specific tb antigen component of the ic was dissociated thermally from tb antibody and assayed by a radioimmunoassay technique developed in our laboratory . | NA | {
"id": "C0003313",
"name": "ic",
"pos": [
10,
12
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
78,
86
]
} |
a recently developed immunological approach to this problem is based on antiserum to an e. coli mutant ( j5 ) which elicits antibody cross-reactive with a wide range of gram-negative pathogens . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
72,
81
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
124,
132
]
} |
the three therapeutic trials of the eortc international antimicrobial therapy project group are reviewed , demonstrating the efficacy of synergistic combinations of aminoglycosides with beta-lactam compounds in the initial empirical therapy of febrile episodes in granulocytopenic patients . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
56,
69
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
165,
180
]
} |
the development of new antiviral agents has introduced effective therapeutic approaches for herpes simplex virus infections and varicella-zoster virus infections . | NA | {
"id": "C0019372",
"name": "herpes simplex virus infections",
"pos": [
92,
123
]
} | {
"id": "C0008049",
"name": "varicella-zoster virus",
"pos": [
128,
150
]
} |
we describe two patients in whom spontaneous angina following acute myocardial infarction ( postinfarction angina caused by coronary artery spasm ) and worsening angina were successfully eliminated after clinical dosage of oral diltiazem , while marked sinus node suppression developed and temporary pacing was performed... | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
45,
51
]
} | {
"id": "C0002965",
"name": "worsening",
"pos": [
152,
161
]
} |
the association of various congenital cardiac abnormalities with pseudocoarctation has been reported , and are similar to those commonly seen with true coarctation . | NA | {
"id": "C0018798",
"name": "congenital cardiac abnormalities",
"pos": [
27,
59
]
} | {
"id": "C0003492",
"name": "coarctation",
"pos": [
152,
163
]
} |
with long-established traditions in both sports medicine and trauma in sweden , investigations are in progress on prevention , diagnosis , treatment , and rehabilitation , with special emphasis on soft-tissue injuries . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
61,
67
]
} | {
"id": "C0037578",
"name": "soft-tissue injuries",
"pos": [
197,
217
]
} |
neutralization of h-d antibodies in representative pathologic sera by purified heterophile antigens showed that the antibodies under investigation were mostly directed against antigen ( s ) of high molecular weight glycoprotein , but not n-glycolyl-neuraminic acid ( ngna ) ganglioside fraction of brbc . | NA | {
"id": "C0003333",
"name": "heterophile antigens",
"pos": [
79,
99
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
176,
183
]
} |
most samples from patients with myelogenous leukemia ( acute phase or remission and cgl chronic phase ) show significantly increased numbers ( greater than or equal to 1 % ) of camal-expressing cells compared to those from normals or individuals with lymphoid leukemias . | NA | {
"id": "C0023470",
"name": "myelogenous leukemia",
"pos": [
32,
52
]
} | {
"id": "C0023473",
"name": "cgl",
"pos": [
84,
87
]
} |
we have found these methods valuable in identifying primary carcinoid tumours and consider them to be the investigations of choice in evaluating patients with suspected or established carcinoid syndrome . | NA | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
60,
69
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
184,
202
]
} |
coagulation disorders in liver disease ( cirrhosis or acute hepatic necrosis ) may be assessed by the laboratory evaluation of factors v , vii , viii and ix , and fibrinolysis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
25,
38
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
41,
50
]
} |
these results indicate that the differences in tissue response elicited by lipids from n. asteroides and m. fortuitum may reside in wax fractions a and d . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
75,
81
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
132,
135
]
} |
sugar ( glucose ) and amino acid ( alanine and leucine ) transport capacities were also distributed according to specific proximo-distal gradients but passive and facilitated diffusions were not affected . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
22,
32
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
35,
42
]
} |
incubation of intact h. diminuta in [ 3h ] tryptophan resulted in substantial radioactivity recovered in 5-ht , 5-hydroxytryptophan ( 5-htp ) , and 5-hydroxyindoleacetic acid ( 5-hiaa ) . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
43,
53
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
134,
139
]
} |
furthermore , the tissue levels of 5-ht and 5-htp , as determined by hplc with electrochemical detection , were significantly depressed when the animals were deprived of tryptophan . | NA | {
"id": "C0000578",
"name": "5-htp",
"pos": [
44,
49
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
170,
180
]
} |
integumental esterases were characterized as carboxylesterases , butyrylcholinesterases and aryl plus acetylesterases by using eserine and paraoxon as inhibitors and acetylthiocholine , butyrylthiocholine and phenylthioacetate as substrates . | NA | {
"id": "C0014894",
"name": "esterases",
"pos": [
13,
22
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
45,
62
]
} |
integumental esterases were characterized as carboxylesterases , butyrylcholinesterases and aryl plus acetylesterases by using eserine and paraoxon as inhibitors and acetylthiocholine , butyrylthiocholine and phenylthioacetate as substrates . | NA | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
45,
62
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterases",
"pos": [
65,
87
]
} |
these parameters were all increased by arterial infusion of adrenaline or noradrenaline , or by infusion of adrenaline via the renal portal veins . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
74,
87
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
108,
118
]
} |
portal venous pressure increased slightly after arterial or portal infusion of adrenaline , but decreased after arterial infusion of noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
79,
89
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
133,
146
]
} |
estimation of segmental pressure gradients indicated that the efferent glomerular arterioles were selectively constricted by low concentrations of adrenaline or noradrenaline ( 3 x 10 ( -9 ) , 3 x 10 ( -8 ) mol l ( -1 ) ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
147,
157
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
161,
174
]
} |
the potent gnrh agonist nafarelin ( d-nal ( 2 ) 6-gnrh ) was administered intranasally in a daily dose of 125 micrograms to 15 women and 250 micrograms to 15 women . | NA | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
24,
33
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
50,
54
]
} |
the proton inventory technique uses the dependence of enzymic reaction rate on the atom fraction of deuterium present in mixtures of protium oxide and deuterium oxide to deduce for simple cases the number of exchangeable hydrogenic sites that produce isotope effects , and the magnitude of the isotope effect generated a... | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
100,
109
]
} | {
"id": "C0011745",
"name": "deuterium oxide",
"pos": [
151,
166
]
} |
to evaluate possible physiologic mechanisms in hemorrhagic shock , sequential hemodynamics , o2 transport , conjunctival o2 ( pcjo2 ) , transcutaneous blood gases ( ptco2 , ptcco2 ) , and core and conjunctival temperature ( tcore , tcj ) were measured during a control period , after hemorrhage , after reinfusion of the... | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
47,
64
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
284,
294
]
} |
ffa levels also increased significantly within 30 min after the infusion was begun , reflecting fatty acids derived from intralipid triglycerides . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
0,
3
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
96,
107
]
} |
after a therapeutic dose of 200 mg pivmecillinam plus 250 mg pivampicillin , the mean peak concentration in serum was 2.3 micrograms mecillinam and 5.3 micrograms ampicillin per ml . | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
61,
74
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
163,
173
]
} |
the 21 asthmatic subjects who had exercise-provoked symptoms required a significantly lower level of ventilation of cold air to produce a 35 percent drop in specific airways conductance ( pd35 ) than did those who had no exercise-induced asthma ( 33.9 l min-1 vs 45.8 l min-1 ; p less than 0.02 ) . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
7,
16
]
} | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
221,
244
]
} |
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