text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
however , the ratios of csf glutamic acid to csf glutamine levels and of csf to serum glutamic acid and glutamine levels were significantly higher only in cirrhotic patients with hepatic encephalopathy . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
28,
41
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
104,
113
]
} |
the results indicate that csf glutamic acid and glutamine levels are important tools in diagnosing hepatic encephalopathy in severe liver disease . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
30,
43
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
48,
57
]
} |
suppression of the cholesterol diet for 48 h in animals cholesterol fed for 48 h had no effect in 12-day-old chicks while the change to a standard diet produced a reversion of the effect of cholesterol feeding in 26-day-old animals . | NA | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
19,
35
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
190,
201
]
} |
in lectin stimulated cells proteins of molecular weight 105 , 75 , 58 and 35 kda contained phosphotyrosine ( p-tyr ) whereas non-stimulated cells had no 105 and low levels of p-tyr in proteins of 75 , 58 and 35 kda . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
3,
9
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
184,
192
]
} |
substance p is found to be the most abundant mammalian tachykinin in every brain region . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
0,
11
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
55,
65
]
} |
these results indicate that both neuromedin k and l are endogenous mammalian tachykinins with specific physiological functions . | NA | {
"id": "C0027847",
"name": "neuromedin k",
"pos": [
33,
45
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
77,
88
]
} |
agonist-induced internalization was very rapid , in the order of few minutes . beta adrenergic receptor internalization was very specific : the alpha adrenergic agonist phenylefrine had almost no effect on beta receptor levels , while isoproterenol treatment had no effect on the number of alpha adrenergic or nicotinic ... | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
235,
248
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
466,
479
]
} |
on addition of the protein kinase the 32p-labelling of both polyphosphoinositides was increased but a higher amount of phosphate was incorporated into phosphatidylinositol-4-phosphate than into phosphatidylinositol-4,5-bisphosphate . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
60,
81
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
194,
214
]
} |
when either glutathione cysteine or n-acetylcysteine were included in the reaction the thiols reduced the acetaminophen-derived radicals to generate thiyl radicals which were trapped with the spin trap 5,5-dimethyl-1-pyrroline-n-oxide ( dmpo ) and observed using epr spectroscopy . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
24,
32
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
36,
52
]
} |
a glycolipid fraction , obtained from dog gastric epithelium by detergent solubilization , was found to contain the glycoconjugates with features common to both glycosphingolipids and glycoproteins . | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
2,
12
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
116,
131
]
} |
a glycolipid fraction , obtained from dog gastric epithelium by detergent solubilization , was found to contain the glycoconjugates with features common to both glycosphingolipids and glycoproteins . | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
2,
12
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
161,
179
]
} |
a glycolipid fraction , obtained from dog gastric epithelium by detergent solubilization , was found to contain the glycoconjugates with features common to both glycosphingolipids and glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
116,
131
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
184,
197
]
} |
it cleaves predominantly at the phe7-phe8 and phe8-gly9 bonds but gives no or negligible conversion of the other tachykinins , neuromedin k and l ( substance k ) . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
113,
124
]
} | {
"id": "C0027847",
"name": "neuromedin k",
"pos": [
127,
139
]
} |
it cleaves predominantly at the phe7-phe8 and phe8-gly9 bonds but gives no or negligible conversion of the other tachykinins , neuromedin k and l ( substance k ) . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
113,
124
]
} | {
"id": "C0038581",
"name": "substance k",
"pos": [
148,
159
]
} |
pregnant rats were injected intrajugularly with 2500 i.u . human chorionic gonadotropin ( hcg ) toward the end of gestation ( days 18-19 ) and 7.0 pmoles of tritiated 25-hydroxyvitamin d3 [ ( 3h ] 25 ( oh ) d3 ) the following day . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
167,
187
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
197,
209
]
} |
the exact role of zinc in the enzyme catalysed hydrolysis of the acylpeptides has been investigated after preparing metallo proteins by substituting the zinc of carboxypeptidase a with co2+ , mn2+ , ni2+ , fe2+ , cd2+ , hg2+ , and cu2+ and determining the kinetic parameters of such metalloproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
124,
132
]
} | {
"id": "C0025544",
"name": "metalloproteins",
"pos": [
283,
298
]
} |
decreases in gtp-stimulated adenylate cyclase activity were also observed following exposure of cells to epinephrine , cc-25 , fenoterol , norepinephrine , terbutaline , or metaproterenol , but not following incubation of cells with dobutamine or salmefamol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
105,
116
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
139,
153
]
} |
brain membrane disordering after acute in vivo administration of ethanol , isopropanol or t-butanol in rats . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
65,
72
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
75,
86
]
} |
in a system of purified proteins comprised of calmodulin , turkey gizzard myosin light chains , and turkey gizzard myosin light chain kinase , the inhibition of myosin light chain phosphorylation by the dihydropyridine ca2+ antagonists felodipine [ 3-ethyl-5-methyl-1-1,4-dihydro-2,6-dimethyl-4- ( 2,3-dichlorophenyl ) -... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
203,
218
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
236,
246
]
} |
in a system of purified proteins comprised of calmodulin , turkey gizzard myosin light chains , and turkey gizzard myosin light chain kinase , the inhibition of myosin light chain phosphorylation by the dihydropyridine ca2+ antagonists felodipine [ 3-ethyl-5-methyl-1-1,4-dihydro-2,6-dimethyl-4- ( 2,3-dichlorophenyl ) -... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
203,
218
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
355,
367
]
} |
the effect was stereospecific and the order of potency of agonists was isoproterenol greater than norepinephrine greater than or equal to epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
138,
149
]
} |
conversely , in rabbit lung membranes , norepinephrine was approximately equipotent with epinephrine in blocking photoincorporation , indicating a beta 1 selectivity . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
40,
54
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
89,
100
]
} |
a diverse group of drugs including phenobarbital and other barbiturates , diphenylhydantoin , glutethimide , aminopyrine and griseofulvin and the steroids dexamethasone and pregnenolone 16 alpha-carbonitrile were shown to induce both ggt and ecd under comparable culture conditions . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
35,
48
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
59,
71
]
} |
the rank potency order of adenosine analogues , neca much greater than adenosine greater than or equal to l-pia greater than or equal to d-pia in both inhibiting and potentiating immunological histamine release suggests that both effects are mediated through activation of cell surface a2-purinoceptors . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
48,
52
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
71,
80
]
} |
( + ) catechin-insoluble elastin complexes were partially resistant to the degradation induced by human leukocyte elastase but were hydrolysed at the same rate as untreated samples by a constant amount of pancreatic elastase . | NA | {
"id": "C0064833",
"name": "human",
"pos": [
98,
103
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
205,
224
]
} |
methanol and ethanol were rapidly metabolized to formaldehyde and acetaldehyde in the presence of ascorbate , 1,10-phenanthroline and either guinea pig hepatic 100,000 g supernatant or 12,000 g pellet fractions . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
0,
8
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
13,
20
]
} |
the influence of an anorganic anion iodide ( i- ) and an organic anion tetraphenylborate ( tpb- ) on the hepatic uptake and biliary excretion of three organic cations , triethylmethyl ammonium ( tema ) , tripropylmethyl ammonium ( tpma ) and tri-n-butylmethyl ammonium ( tbuma ) was studied . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
30,
35
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
287,
288
]
} |
the acid neutralizing capacity of a new antacid , almagate ( hydrated aluminium-magnesium hydroxycarbonate , al2mg6 ( oh ) 14 ( co3 ) 2 x 4 h2o , almax ) has been compared with that of a popular mixture of aluminium-magnesium hydroxide codried gel , aluminium hydroxide and calcium carbonate ( antacid a ) using a transi... | NA | {
"id": "C2930042",
"name": "aluminium-magnesium hydroxide",
"pos": [
206,
235
]
} | {
"id": "C0002371",
"name": "aluminium hydroxide",
"pos": [
250,
269
]
} |
at least five metabolites of 5-ismn were detected in urine - these were isosorbide ( about 37 % dose ) , conjugated material ( about 25 % dose ) presumably mainly 5-ismn-glucuronide , sorbitol ( about 7 % dose ) , the parent drug 5-ismn ( about 2 % dose ) and two unidentified metabolites ( about 7 and 4 % dose , respec... | NA | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
72,
82
]
} | {
"id": "C0037688",
"name": "sorbitol",
"pos": [
184,
192
]
} |
the effect of the new 1,4-dihydropyridine calcium antagonist nisoldipine on electrophysiological parameters was investigated in 10 patients who were pretreated with a beta-blocker . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
26,
60
]
} | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
61,
72
]
} |
famotidine like the other guanidino-thiazole containing compound tiotidine appears to be free from this unwanted effect on drug metabolism in the liver . | NA | {
"id": "C0015620",
"name": "famotidine",
"pos": [
0,
10
]
} | {
"id": "C0039859",
"name": "thiazole",
"pos": [
36,
44
]
} |
it concerns the three human trematode infections prevalent in this country , namely clonorchiasis , paragonimiasis and metagonimiasis . | NA | {
"id": "C0040820",
"name": "trematode infections",
"pos": [
28,
48
]
} | {
"id": "C0009021",
"name": "clonorchiasis",
"pos": [
84,
97
]
} |
it concerns the three human trematode infections prevalent in this country , namely clonorchiasis , paragonimiasis and metagonimiasis . | NA | {
"id": "C0040820",
"name": "trematode infections",
"pos": [
28,
48
]
} | {
"id": "C0030424",
"name": "paragonimiasis",
"pos": [
100,
114
]
} |
thus , except in schistosomiasis , the most practical method of preventing human trematode infections is to avoid eating raw , freshly pickled or imperfectly cooked fresh-water fish , crayfish or crabs , etc . | NA | {
"id": "C0036323",
"name": "schistosomiasis",
"pos": [
17,
32
]
} | {
"id": "C0040820",
"name": "trematode infections",
"pos": [
81,
101
]
} |
we have previously shown that proprietary naloxone hydrochloride ( narcan ) reverses the disturbance of the redox states of the hepatic nad ( p ) couples and causes a simultaneous lowering of blood-ethanol concentration in acutely-ethanol-intoxicated rats . | NA | {
"id": "C0684262",
"name": "blood-ethanol concentration",
"pos": [
192,
219
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
231,
238
]
} |
the clinical status which met the criteria of brain death might therefore possibly imply any conditions in which brain death was impending gradually to result in the total brain death of cerebrum through medulla oblongata . | NA | {
"id": "C0006111",
"name": "conditions",
"pos": [
93,
103
]
} | {
"id": "C0006110",
"name": "brain death",
"pos": [
172,
183
]
} |
food moderately weakened the effect of activated charcoal administered 5 min after the drugs , but when the charcoal was given 1 h later the effect was still practically the same , the reduction of absorption varying in both cases in the range of 45-85 % . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
39,
57
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
108,
116
]
} |
population data analysed from two centres ( 43 infants from glasgow and 100 infants and children from manchester ) by the computer program nonmem showed that volume of distribution was related to body weight by a proportionality factor that decreased from the region of 0.41-0.46 l/kg in children less than 3 months to 0... | NA | {
"id": "C0008059",
"name": "children",
"pos": [
88,
96
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
337,
351
]
} |
indobufen interacts with the sulphonylurea , glipizide , but not with the beta-adrenergic receptor antagonists , propranolol and atenolol . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
29,
42
]
} | {
"id": "C0017642",
"name": "glipizide",
"pos": [
45,
54
]
} |
this study assessed the possible interactions of the cyclooxygenase inhibitor indobufen with one sulphonylurea , glipizide , and with two beta-adrenoceptor antagonists , one of which is extensively metabolised already in the first passage through the liver ( propranolol ) while the other essentially escapes biotransfor... | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
97,
110
]
} | {
"id": "C0017642",
"name": "glipizide",
"pos": [
113,
122
]
} |
the protein binding of timegadine to albumin , serum , plasma and plasma enriched with the acute phase reactants alpha 1-acid glycoprotein , alpha 1-anti-trypsin and c-reactive protein was determined by equilibrium dialysis . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
91,
112
]
} | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
113,
138
]
} |
the protein binding of timegadine to albumin , serum , plasma and plasma enriched with the acute phase reactants alpha 1-acid glycoprotein , alpha 1-anti-trypsin and c-reactive protein was determined by equilibrium dialysis . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
91,
112
]
} | {
"id": "C0002191",
"name": "alpha 1-anti-trypsin",
"pos": [
141,
161
]
} |
the protein binding of timegadine to albumin , serum , plasma and plasma enriched with the acute phase reactants alpha 1-acid glycoprotein , alpha 1-anti-trypsin and c-reactive protein was determined by equilibrium dialysis . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
91,
112
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
166,
184
]
} |
low-contrast charts also detect visual loss in patients with ocular hypertension , glaucoma , and parkinson 's disease , including patients with normal visual acuity . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
61,
80
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
83,
91
]
} |
bacteria harboring the plasmid are resistant to the kanomycins plus a broad range of other deoxystreptamine-containing aminoglycosides but not to the gentamicins xk62-2 and c1 which are substituted at the 6'-position . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
119,
134
]
} | {
"id": "C0017436",
"name": "gentamicins",
"pos": [
150,
161
]
} |
substrate specificity studies on the purified enzyme , however , now show that the enzyme acetylates an even broader range of aminoglycosides , including the gentamicins xk62-2 and c1 . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
126,
141
]
} | {
"id": "C0017436",
"name": "gentamicins",
"pos": [
158,
169
]
} |
for the active enzyme-phospholipid complex in the absence of ligands , we previously found that reaction with n-ethylmaleimide ( at 5 mol/mol of enzyme subunit ) resulted in progressive loss of enzymic activity with an inactivation stoichiometry of 1 equiv of sulfhydryl derivatized per mole of enzyme and a maximum deri... | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
15,
21
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
295,
301
]
} |
dehydration rate constants ( s-1 at ph 8-8.5 , 0.1 m buffer , 25 degrees c ) for the following aldehydes ( all over 95 % hydrated ) and kinases used are as follows : d-glyceraldehyde with glycerokinase , 0.03 ; | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
95,
104
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
168,
182
]
} |
aldehyde analogues of the normal alcohol substrates induce atpase activities by glycerokinase ( d-glyceraldehyde ) , fructose-6-phosphate kinase ( 2,5-anhydromannose 6-phosphate ) , fructokinase ( 2,5-anhydromannose or 2,5-anhydrotalose ) , hexokinase ( d-gluco-hexodialdose ) , choline kinase ( betaine aldehyde ) , and... | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
0,
8
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
98,
112
]
} |
kinases that phosphorylate creatine , 3-phosphoglycerate , and acetate did not exhibit atpase activities in the presence of keto or aldehyde analogues ( n-methylhydantoic acid , d-glyceraldehyde 3-phosphate , and acetaldehyde , respectively ) , possibly because of the absence of an acid-base catalytic group in the latt... | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
132,
140
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
213,
225
]
} |
the interaction of angiotensin converting enzyme with six metal-coordinating [ ( d-3-mercapto-2-methylpropanoyl ) -l-pro ( captopril ) , n- [ 1 ( s ) -carboxy-3-phenylpropyl ] -l-ala-l-pro ( mk-422 ) , n- ( phenylphosphoryl ) -l-phe-l-phe , n alpha- ( 3-mercaptopropanoyl ) -l-arg , n alpha- [ 1 ( s ) -carboxy-3-phenylp... | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
123,
132
]
} | {
"id": "C0033382",
"name": "pro",
"pos": [
467,
470
]
} |
the present study examines the chloride dependence of the inhibition of ace by nine inhibitors [ ( d-3-mercapto-2-methylpropanoyl ) -l-pro ( captopril ) , n- [ 1 ( s ) -carboxy-3-phenylpropyl ] -l-ala-l-pro ( mk-422 ) , l-ala-l-pro , n- ( phenylphosphoryl ) -l-phe-l-phe , gly-l-trp , n- [ 1 ( s ) -carboxy-5-aminopentyl... | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
141,
150
]
} | {
"id": "C0033382",
"name": "pro",
"pos": [
432,
435
]
} |
kinetic isotope effects on the oxidation of reduced nicotinamide adenine dinucleotide phosphate by the flavoprotein methylenetetrahydrofolate reductase . | NA | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
103,
115
]
} | {
"id": "C0066357",
"name": "methylenetetrahydrofolate reductase",
"pos": [
116,
151
]
} |
alpha-secondary deuterium isotope effects with formate dehydrogenase are decreased halfway to the equilibrium isotope effect when deuterated formate is the substrate , showing that the bending motion of the secondary hydrogen is coupled to hydride transfer in the transition state and that tunneling of the two hydrogens... | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
16,
25
]
} | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
311,
320
]
} |
desferrioxamine , which completely blocks the production of .oh by microsomes , inhibited the oxidation of ethanol by about 60 % , while the oxidation of 2-butanol and 1-butanol was decreased by only 30 % . | NA | {
"id": "C0001977",
"name": "butanol",
"pos": [
156,
163
]
} | {
"id": "C0089147",
"name": "1-butanol",
"pos": [
168,
177
]
} |
when deoxygenation shift effects in adult cells were compared to those of cord blood cells containing 70 % fetal hemoglobin , it was found that 45 % of the 2,3-dpg shift effects were attributable to binding of that compound to hemoglobin . | NA | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
107,
123
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
227,
237
]
} |
edc treatment leads to crosslinking of erythrocyte membrane proteins , but differences between the time course of this action and inhibition of transport indicate that most transport inhibition is not due to crosslinking of membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
60,
68
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
224,
232
]
} |
the high molecular weight filter-bound dna samples were sedimented to equilibrium in cscl buoyant density gradients and found to contain primarily mouse satellite dna density sequences ( 1.691 g/cm3 ) with some minor fractions at other density positions ( 1.670 , 1.682 , 1.705 , 1.740 , 1.760 g/cm3 ) similar to those o... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
39,
42
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
153,
166
]
} |
heating the phage to 70 degrees c for several hours leads to additional deuterium exchange compared to samples soaked for 5 months in heavy water . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
72,
81
]
} | {
"id": "C0011745",
"name": "heavy water",
"pos": [
134,
145
]
} |
similar relative intensities of lectin-binding were obtained for corresponding proteins in normal and cancerous tissue fractions . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
32,
38
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
79,
87
]
} |
the 35 kda protein is a group of at least eight isoforms ranging in relative molecular mass mr from 32 to 36 kda with isoelectric points between 4.8 and 5.5 . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
11,
18
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
48,
56
]
} |
in order to further investigate the effect of cross-linked hemoglobin tetramers on sickle hemoglobin polymerization , we separated cross-linked hemoglobin tetramers on a gel-filtration column , prepared mixtures of untreated sickle hemoglobin and cross-linked hemoglobin tetramers and studied the polymerization of these... | NA | {
"id": "C0019016",
"name": "hemoglobin",
"pos": [
59,
69
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
260,
270
]
} |
the distribution of apolipoprotein e isomorphs and the individual c apolipoproteins were similar in each fraction . | NA | {
"id": "C0003595",
"name": "apolipoprotein e",
"pos": [
20,
36
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
68,
83
]
} |
peroxidase extracted from isolated rat eosinophils also cross-reacted with the antibody and yielded identical titers as the spleen and uterine peroxidases . | NA | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
0,
10
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
143,
154
]
} |
it was found that in vitro both forward and reverse fluxes through creatine kinase at equilibrium were almost equal and very stable to changes in phosphocreatine/creatine ratio ( from 0.2 to 3.0 ) as well as to changes in ph ( from 7.4 to 6.5 or 8.1 ) , free mg2+ concentration and 2-fold decrease of total adenine nucle... | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
146,
161
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
331,
339
]
} |
these changes could not be exclusively explained on the basis of the equilibrium model by activation of heart creatine kinase due to some decrease in [ phosphocreatine ] / [ creatine ] ratio ( from 1.8 to 0.8 ) observed during transition from rest to high workload . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
152,
167
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
174,
182
]
} |
during the treatment phase , a near-100 % reduction in amount of weekly prn pain medication ingested was noted , along with a decrease in self-reports of head pain . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
76,
80
]
} | {
"id": "C0018681",
"name": "in",
"pos": [
161,
163
]
} |
the instrument was given to 474 students ( 254 females , 206 males , and 14 who failed to indicate their gender ) . | NA | {
"id": "C0086582",
"name": "males",
"pos": [
49,
54
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
105,
111
]
} |
glycosidase activities in principal cells , basal cells , fibroblasts and spermatozoa isolated from the rat epididymis . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
36,
41
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
58,
69
]
} |
the activity levels of beta-n-acetylglucosaminidase , beta-n-acetylgalactosaminidase , beta-galactosidase and beta-glucosidase were fluorometrically assessed in spermatozoa , principal cells , basal cells and fibroblasts isolated from the rat epididymis by centrifugal elutriation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
185,
190
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
209,
220
]
} |
although ac was activated 2- to 3-fold at all cycle stages by 10 mm naf , the resulting pattern of activity was similar to that measured in the absence of fluoride . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
68,
71
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
155,
163
]
} |
the described procedure of obtaining fibroblast-free decidual cell monolayers will promote studies on the hormonal regulation of this tissue at the time of early intrauterine life . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
37,
47
]
} |
monensin , a specific sodium ionophore , has been shown to reduce glucose-induced proinsulin biosynthesis by 30 % and to completely inhibit the intracellular conversion of proinsulin to insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
82,
92
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
186,
193
]
} |
this phenomenon evidences that vasodilatation occurring at the late stages of the shock development is determined not only by a reduction in the concentration of endogenous adrenaline and noradrenaline but also by a decrease in the sensitivity of microvessels to these agents . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
173,
183
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
188,
201
]
} |
the protonophore p-trichloromethoxycarbonyl cyanide phenylhydrazone ( 20 microm ) and bicarbonate anions ( 20 mm ) stimulate slightly ( by 12 to 25 % ) mg-atpase of the sv . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
44,
51
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
98,
104
]
} |
it was established that during the period that preceded the development of heart rhythm disorders , the most conspicuous changes were seen in the electric activity of the anterior amygdaline nucleus and lc , whereas the coagulation of the amygdalae prevented to a considerable measure development of different forms of a... | NA | {
"id": "C0018799",
"name": "the",
"pos": [
31,
34
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
319,
329
]
} |
morphological , laboratory , and radionuclide studies attest to adequate perfusion of the myocardium with the aid of the laser canals preventing the development of myocardial ischemia and infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
175,
183
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
188,
198
]
} |
6,9-deepoxy- 6,9- ( phenylimino ) -delta 6,8-prostaglandin i1 ( u-60,257 ) , a prostaglandin analogue known to inhibit leukotriene formation in a number of cell systems , potentiates mast cell release of prostaglandin d2 from human dispersed lung cells activated with ionophore a23187 . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
45,
58
]
} | {
"id": "C0033568",
"name": "prostaglandin analogue",
"pos": [
79,
101
]
} |
idazoxan 300 micrograms kg-1 i.v . and 50 micrograms i.c.v . prevented clonidine-induced falls in plasma noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
105,
118
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
123,
133
]
} |
dibutyryl cyclic amp ( db-cyclic amp ) caused differential effects on the synthesis of pge2 and thromboxane . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
0,
20
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
26,
36
]
} |
the significant associations of appetite and weight change during treatment were with weight , appetite , and carbohydrate preference at presentation , and also with the 'appetite history ' and 'weight history ' . | NA | {
"id": "C0005911",
"name": "weight change",
"pos": [
45,
58
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
195,
201
]
} |
the hypothalamic - pituitary - gonadal axis was evaluated in men with paedophilia and non-paedophilic paraphilia , and in normal male controls , by infusion of 100 mcg . of synthetic luteinising hormone-releasing hormone ( lhrh ) . | NA | {
"id": "C0030764",
"name": "paedophilia",
"pos": [
70,
81
]
} | {
"id": "C0030482",
"name": "paraphilia",
"pos": [
102,
112
]
} |
gaba , muscimol and l-baclofen inhibited zona compacta neurons in the rat substantia nigra slice , d-baclofen was inactive , l-baclofen produced a potent hyperpolarization of the membrane potential . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
127,
135
]
} |
over the dose range 10 ( -12 ) -10 ( -9 ) mol angiotensin ( ai ) , angiotensin ii ( aii ) , angiotensin iii ( aiii ) , and renin substrate ( rs ) , the volumes of water and salt solution ingested were dose-dependent . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
46,
57
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
92,
106
]
} |
over the dose range 10 ( -12 ) -10 ( -9 ) mol angiotensin ( ai ) , angiotensin ii ( aii ) , angiotensin iii ( aiii ) , and renin substrate ( rs ) , the volumes of water and salt solution ingested were dose-dependent . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
46,
57
]
} | {
"id": "C0003012",
"name": "angiotensin iii",
"pos": [
92,
107
]
} |
over the dose range 10 ( -12 ) -10 ( -9 ) mol angiotensin ( ai ) , angiotensin ii ( aii ) , angiotensin iii ( aiii ) , and renin substrate ( rs ) , the volumes of water and salt solution ingested were dose-dependent . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
46,
57
]
} | {
"id": "C0003017",
"name": "renin substrate",
"pos": [
123,
138
]
} |
however , unlike in the rat , dog and pigeon , aiii was highly effective in stimulating both water intake and salt appetite , whereas ai and rs were relatively weak . | NA | {
"id": "C0003012",
"name": "aiii",
"pos": [
47,
51
]
} | {
"id": "C0003018",
"name": "ai",
"pos": [
134,
136
]
} |
however , unlike in the rat , dog and pigeon , aiii was highly effective in stimulating both water intake and salt appetite , whereas ai and rs were relatively weak . | NA | {
"id": "C0003018",
"name": "ai",
"pos": [
47,
49
]
} | {
"id": "C0003017",
"name": "rs",
"pos": [
141,
143
]
} |
pretreatment of intracranial sites with 10 ( -9 ) mol of the aii competitive antagonist , sar1-ala8-angiotensin , had no effect on the volume of water or 1.8 % nacl ingested after 10 ( -10 ) mol aiii , suggesting that in the pig aiii can exert its dipsogenic effects without acting on central aii receptors . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
61,
64
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
100,
111
]
} |
pretreatment of intracranial sites with 10 ( -9 ) mol of the aii competitive antagonist , sar1-ala8-angiotensin , had no effect on the volume of water or 1.8 % nacl ingested after 10 ( -10 ) mol aiii , suggesting that in the pig aiii can exert its dipsogenic effects without acting on central aii receptors . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
100,
111
]
} | {
"id": "C0003012",
"name": "aiii",
"pos": [
229,
233
]
} |
moreover , recent work from my laboratory indicates that in vitro at alkaline ph in the presence of mg2+ , the biologically active diphenols ( beta-3,4-dihydroxyphenylalanine and the beta-adrenergic agonists isoproterenol , norepinephrine , and epinephrine ) appear to function as electron donor substrates for human ery... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
224,
238
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
245,
256
]
} |
the optical absorption of p. mirabilis pr catalase in the presence of various anionic species ( cyanide , azide , formate ) was examined . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
78,
85
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
96,
103
]
} |
a heparin fraction with very low affinity to thrombin and high affinity to antithrombin iii was prepared by repeated fractionation of a low molecular weight heparin on the two affinity columns . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
2,
9
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
136,
164
]
} |
the results of these studies support the concept that , for both standard and low molecular weight heparin , the enhancement of the inactivation of thrombin by antithrombin iii requires the interaction of the heparin with both thrombin and antithrombin iii . | NA | {
"id": "C0019139",
"name": "low",
"pos": [
78,
81
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
209,
216
]
} |
low density lipoprotein ( ldl ) increased secretion of glycosaminoglycans ( gag ) and the cell cholesterol content of proliferating fibroblasts and smooth muscle cells in culture ; | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
86,
94
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
132,
143
]
} |
using prototypic ligands for each type of opioid receptors ( mu , delta , kappa , and sigma ) as well as compounds derived from each class of endogenous opioid peptides ( beta-endorphin , enkephalins , and dynorphins ) , we have undertaken the characterization of adrenomedullary opioid binding sites . | NA | {
"id": "C0205753",
"name": "endogenous opioid",
"pos": [
142,
159
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
188,
199
]
} |
using prototypic ligands for each type of opioid receptors ( mu , delta , kappa , and sigma ) as well as compounds derived from each class of endogenous opioid peptides ( beta-endorphin , enkephalins , and dynorphins ) , we have undertaken the characterization of adrenomedullary opioid binding sites . | NA | {
"id": "C0205753",
"name": "endogenous opioid",
"pos": [
142,
159
]
} | {
"id": "C0013355",
"name": "dynorphins",
"pos": [
206,
216
]
} |
for the ionic amphipathic agents , the direction of the changes in the relation between ko and k-contracture tension could be accounted for on the basis of the expected changes in surface charge , but the effects of these two types of agents on the rate of relaxation of submaximum k contractures were disproportionate a... | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
8,
13
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
332,
340
]
} |
for the ionic amphipathic agents , the direction of the changes in the relation between ko and k-contracture tension could be accounted for on the basis of the expected changes in surface charge , but the effects of these two types of agents on the rate of relaxation of submaximum k contractures were disproportionate a... | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
332,
340
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
406,
422
]
} |
sufficiently high concentrations of cationic ( n-alkyl trimethylammonium ) or neutral ( n-alkanols ) amphipathic agents reduced the amplitude of maximum k contractures of frog toe muscles , an effect which was antagonized by reduced temperature , by the presence of perchlorate anions , or ( to a lesser extent ) by an i... | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
36,
44
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
346,
362
]
} |
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